CN102727486A - 线叶旋覆花内酯a在制备治疗心肌炎药物中的应用 - Google Patents
线叶旋覆花内酯a在制备治疗心肌炎药物中的应用 Download PDFInfo
- Publication number
- CN102727486A CN102727486A CN2012102081729A CN201210208172A CN102727486A CN 102727486 A CN102727486 A CN 102727486A CN 2012102081729 A CN2012102081729 A CN 2012102081729A CN 201210208172 A CN201210208172 A CN 201210208172A CN 102727486 A CN102727486 A CN 102727486A
- Authority
- CN
- China
- Prior art keywords
- inula lineariifolia
- lineariifolia lactone
- lactone
- inula
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
组别 | 动物数 | 生存时间M(天) | SD | P |
病毒对照 | 10 | 7.3 | 0.48 | |
干扰素 | 10 | 8.4 | 2.11 | 0.12 |
线叶旋覆花内酯A 100mg/kg | 10 | 9.4 | 2.5 | 0.018* |
线叶旋覆花内酯A 50mg/kg | 10 | 9 | 1.89 | 0.013* |
线叶旋覆花内酯A 10mg/kg | 10 | 8.9 | 1.85 | 0.017* |
组别 | 用药前 | 4天 | 8天 | 14天 | ||||
M±SD | P | M±SD | P | M±SD | P | M±SD | P | |
病毒组 | 14.65±0.59 | 1 | 12.84±0.92 | 0** | ||||
100mg/Kg | 14.57±0.55 | 0.75 | 15.13±0.88 | 0.00021** | 16.1±1.05 | 0** | 18.21±0.86 | 0** |
50mg/Kg | 14.58±0.49 | 0.77 | 15.14±0.68 | 0** | 16.03±0.96 | 0** | 18.33±0.80 | 0** |
10mg/Kg | 14.59±0.71 | 0.84 | 15.23±1.01 | 0** | 15.59±0.89 | 0** | 17.92±1.10 | 0** |
干扰素 | 14.53±0.59 | 0.65 | 14.80±1.50 | 0.0016** | 15.82±0.47 | 0** | 18.07±0.88 | 0** |
正常组 | 14.65±0.56 | 16.77±0.75 | 19.06±0.77 | 22.65±1.03 |
组别(n=4) | 1:X(7天) | 1:X(14天) |
100mg/kg | 1:169 | 1:250 |
50mg/kg | 1:139 | 1:250 |
10mg/kg | 1:74 | 1:250 |
干扰素 | 1:1250 | 1:1250 |
病毒对照组 | 1:96 | |
正常对照组 | 1:50 | 1:50 |
Claims (4)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012102081729A CN102727486B (zh) | 2012-06-21 | 2012-06-21 | 线叶旋覆花内酯a在制备治疗心肌炎药物中的应用 |
PCT/CN2012/001306 WO2013188996A1 (zh) | 2012-06-21 | 2012-09-25 | 线叶旋覆花内酯a在制备治疗心肌炎药物中的应用 |
EP12879465.8A EP2865380A4 (en) | 2012-06-21 | 2012-09-25 | USE OF INULA LINEARIIFOLIA LACTONE IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF MYOCARDITIS |
US14/576,027 US9303006B2 (en) | 2012-06-21 | 2014-12-18 | Line leaf inula flower lactone A and methods for preparing and using the same for treating myocarditis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012102081729A CN102727486B (zh) | 2012-06-21 | 2012-06-21 | 线叶旋覆花内酯a在制备治疗心肌炎药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102727486A true CN102727486A (zh) | 2012-10-17 |
CN102727486B CN102727486B (zh) | 2013-12-25 |
Family
ID=46984256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2012102081729A Active CN102727486B (zh) | 2012-06-21 | 2012-06-21 | 线叶旋覆花内酯a在制备治疗心肌炎药物中的应用 |
Country Status (4)
Country | Link |
---|---|
US (1) | US9303006B2 (zh) |
EP (1) | EP2865380A4 (zh) |
CN (1) | CN102727486B (zh) |
WO (1) | WO2013188996A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106478570A (zh) * | 2015-08-31 | 2017-03-08 | 山西振东先导生物科技有限公司 | 二甲基胺4-o-乙酰基线叶旋覆花内酯a或其盐及其制备与应用 |
CN107998122A (zh) * | 2016-10-28 | 2018-05-08 | 山西振东先导生物科技有限公司 | 线叶旋覆花内酯a在制备预防/治疗慢性阻塞性肺疾病药物中的应用 |
CN112315962A (zh) * | 2020-11-17 | 2021-02-05 | 北京化工大学 | 霉酚酸在治疗和预防柯萨奇病毒感染中的应用 |
CN113398117A (zh) * | 2021-06-02 | 2021-09-17 | 山西振东先导生物科技有限公司 | 二甲基胺4-o-乙酰基线叶旋覆花内酯a及其盐在制备治疗慢性肾衰竭药物中的应用 |
CN113907047A (zh) * | 2021-12-13 | 2022-01-11 | 天津医科大学总医院空港医院 | 一种自身抗原表位诱导的eam小鼠模型的建立方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1957939A (zh) * | 2005-11-06 | 2007-05-09 | 温进坤 | 用abl及其乙酰化同系物调制血管炎症反应和防治慢性血管炎症性疾病 |
CN101830875A (zh) * | 2010-06-13 | 2010-09-15 | 上海交通大学 | 抗炎化合物线叶旋覆花内酯a及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101150643B1 (ko) | 2010-01-26 | 2012-05-25 | 주식회사유한양행 | 선복화 추출물로부터 분리된 화합물을 유효성분으로 함유하는 염증 또는 알러지 질환의 예방 및 치료용 조성물 |
CN102727485B (zh) | 2012-06-21 | 2014-07-23 | 中国人民解放军第二军医大学 | 线叶旋覆花内酯a在制备治疗多发性硬化症药物中的应用 |
-
2012
- 2012-06-21 CN CN2012102081729A patent/CN102727486B/zh active Active
- 2012-09-25 WO PCT/CN2012/001306 patent/WO2013188996A1/zh unknown
- 2012-09-25 EP EP12879465.8A patent/EP2865380A4/en not_active Withdrawn
-
2014
- 2014-12-18 US US14/576,027 patent/US9303006B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1957939A (zh) * | 2005-11-06 | 2007-05-09 | 温进坤 | 用abl及其乙酰化同系物调制血管炎症反应和防治慢性血管炎症性疾病 |
CN101830875A (zh) * | 2010-06-13 | 2010-09-15 | 上海交通大学 | 抗炎化合物线叶旋覆花内酯a及其制备方法和应用 |
Non-Patent Citations (1)
Title |
---|
黄志刚等: "NO与小鼠病毒性心肌炎发生发展的关系", 《中国地方病学杂志》, vol. 19, no. 5, 30 September 2000 (2000-09-30), pages 330 - 332 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106478570A (zh) * | 2015-08-31 | 2017-03-08 | 山西振东先导生物科技有限公司 | 二甲基胺4-o-乙酰基线叶旋覆花内酯a或其盐及其制备与应用 |
WO2017036392A1 (zh) * | 2015-08-31 | 2017-03-09 | 山西振东先导生物科技有限公司 | 一种线叶旋覆花内酯a衍生物 |
CN107849002A (zh) * | 2015-08-31 | 2018-03-27 | 山西振东先导生物科技有限公司 | 一种线叶旋覆花内酯a衍生物 |
CN106478570B (zh) * | 2015-08-31 | 2019-04-05 | 山西振东先导生物科技有限公司 | 二甲基胺4-o-乙酰基线叶旋覆花内酯a或其盐及其制备与应用 |
CN107849002B (zh) * | 2015-08-31 | 2021-07-06 | 山西振东先导生物科技有限公司 | 一种线叶旋覆花内酯a衍生物 |
CN107998122A (zh) * | 2016-10-28 | 2018-05-08 | 山西振东先导生物科技有限公司 | 线叶旋覆花内酯a在制备预防/治疗慢性阻塞性肺疾病药物中的应用 |
CN112315962A (zh) * | 2020-11-17 | 2021-02-05 | 北京化工大学 | 霉酚酸在治疗和预防柯萨奇病毒感染中的应用 |
CN112315962B (zh) * | 2020-11-17 | 2022-03-29 | 北京化工大学 | 霉酚酸在治疗和预防柯萨奇病毒感染中的应用 |
CN113398117A (zh) * | 2021-06-02 | 2021-09-17 | 山西振东先导生物科技有限公司 | 二甲基胺4-o-乙酰基线叶旋覆花内酯a及其盐在制备治疗慢性肾衰竭药物中的应用 |
CN113398117B (zh) * | 2021-06-02 | 2023-08-08 | 山西振东先导生物科技有限公司 | 二甲基胺4-o-乙酰基线叶旋覆花内酯a及其盐在制备治疗慢性肾衰竭药物中的应用 |
CN113907047A (zh) * | 2021-12-13 | 2022-01-11 | 天津医科大学总医院空港医院 | 一种自身抗原表位诱导的eam小鼠模型的建立方法 |
Also Published As
Publication number | Publication date |
---|---|
CN102727486B (zh) | 2013-12-25 |
EP2865380A4 (en) | 2015-08-05 |
US20150105457A1 (en) | 2015-04-16 |
EP2865380A1 (en) | 2015-04-29 |
WO2013188996A1 (zh) | 2013-12-27 |
US9303006B2 (en) | 2016-04-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5057987B2 (ja) | 薬草組成物phy906及びその化学療法における使用 | |
JP5064630B2 (ja) | 薬草組成物phy906および化学療法におけるその使用 | |
CN102727486B (zh) | 线叶旋覆花内酯a在制备治疗心肌炎药物中的应用 | |
CN101002906A (zh) | 一种中药复方及其用途 | |
US9278948B2 (en) | Line leaf inula flower lactone A and methods for preparing and using the same for treating multiple sclerosis | |
WO2007059685A1 (fr) | Calycosine d'astragalus a fonction de resistance contre le coxackievirus | |
CN102488838B (zh) | 治疗病毒性心肌炎的中药组合物 | |
CN100431594C (zh) | 一种用于治疗暑湿型感冒的复方制剂及其制备方法 | |
CN106727898B (zh) | 一种防治阿尔茨海默病的药物组合物及其制备方法 | |
CN101732585A (zh) | 一种治疗偏头痛的药物组合物、制备方法及用途 | |
CN105963500B (zh) | 一种治疗感冒的中药制剂及其制备方法和检测方法 | |
CN101199806A (zh) | 一种治疗腹泻的药物及其制备方法和质量控制方法 | |
CN104189346B (zh) | 一种促胃肠动力的药物组合物及其制备方法 | |
CN102552440B (zh) | 一种平喘消炎药物及其制备方法和用途 | |
CN101028311B (zh) | 中药卷柏的新用途 | |
CN115227757B (zh) | 一种中药组合物在制备降压药物中的应用 | |
CN115337348B (zh) | 一种治疗热结血脉的中药组合物 | |
CN115337347B (zh) | 一种中药组合物在制备治疗冠心病的药物中的应用 | |
CN102697800A (zh) | 繁缕多糖组合物及其在制备抗病毒药物中的应用 | |
CN116270787B (zh) | 一种中西复方药物在制备治疗白血病药物中的应用 | |
TWI386219B (zh) | 用以治療子宮頸癌之植物衍生化合物與複方 | |
CN101618157B (zh) | 一种用于治疗秋燥感冒的药物组合物及其制备方法 | |
CN102058668A (zh) | 一种治疗原发性血小板减少的中药制剂 | |
CN108743796B (zh) | 一种治疗肺癌的中药组合物及其应用 | |
CN101816721B (zh) | 一种治疗小儿外感发热的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANXI ZHENDONG PILOT BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: ARMY MEDICAL UNIV. NO.2, CHINESE PLA Effective date: 20141125 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 200433 YANGPU, SHANGHAI TO: 047100 CHANGZHI, SHAANXI PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20141125 Address after: 047100 Shanxi County of Changzhi province science and Technology Park Zhendong road light Patentee after: Shanxi Zhendong leading Biotechnology Co. Ltd. Address before: 200433 Yangpu District Xiang Yin Road, No. 800, Shanghai Patentee before: Army Medical Univ. No.2, Chinese PLA |
|
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 030602 No. 8, Jinzhong Development Zone, Shanxi (ante pharmaceutical hospital) Patentee after: Shanxi Zhendong leading Biotechnology Co. Ltd. Address before: 047100 Shanxi County of Changzhi province science and Technology Park Zhendong road light Patentee before: Shanxi Zhendong leading Biotechnology Co. Ltd. |