CN102716459B - Chinese medicinal composition for treating senile mild cognitive impairment and preparation method thereof - Google Patents
Chinese medicinal composition for treating senile mild cognitive impairment and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating senile mild cognitive impairment. The Chinese medicinal composition consists of forty eight Chinese medicines such as ginseng, astragalus, Chinese angelica, hairy deerhorn, chrysanthemum and mint, and has a good effect on senile mild cognitive impairment; the traditional Chinese medicine proves that the effective rate of the curative effect is 90.63 percent, and the stability rate is 96.88 percent; and the Chinese medicinal composition has a remarkable curative effect on hypomnesis caused by brain tissue aging (the total score P of a clinical memory scale is 0.000).
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, be specifically related to a kind of Chinese medicine composition for the treatment of old mild cognitive impairment and preparation method thereof, belong to field of medicaments.
Background technology
Along with development and the universal of various commonly encountered diseases knowledge of modern social economy are also deepened understanding, the understanding of people to various diseases especially day by day.A lot of old peoples more and more focus on the quality of life in old age, and cognitive disorder patient brings a lot of inconvenience to oneself and household.
Mild cognitive impairment (mild cognitive impairment, MCI) refers to that one has mild cognitive impairment but there is no dull-witted classification of diseases unit, is the transitive state between normal and dementia.Research shows, MCI is dull-witted high risk factor, and the incidence rate in old people is approximately 5.3%, and develops into dementia with ratios annual 15%, every 2 years 40%, every 3 years 53%.Therefore, MCI has been widely accepted as the early warning signal of dementia morbidity and new treatment target spot.
The dull-witted main medicine of applying cholinesterase inhibitor, excitatory amino acid receptor antagonists, affecting Radical Metabolism of western medicine at present, with brain metabolism reinforcing agent etc., although obtained clinically certain curative effect, there is certain advantage, but toleration, toxicity incidence rate and price are not as good as Chinese medicine.Under Overall View in long-term clinical practice and in System of Chinese medicine instructs considering determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Chinese medicine at relief of symptoms, improve and on quality of life, had obvious immeasurable effect.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of old mild cognitive impairment.
Another object of the present invention is to provide the preparation method of this Chinese medicine composition.
Another object of the present invention is to provide the application of a kind of Chinese medicine composition in hypomnesis medicine due to preparation treatment cerebral tissue is aging.
Another object of the present invention is to provide the application of a kind of Chinese medicine composition in preparation treatment mild cognitive impairment medicine.
The object of the invention is to be achieved through the following technical solutions:
Treat a Chinese medicine composition for old mild cognitive impairment, the crude drug of this Chinese medicine composition consists of:
Radix Ginseng 5-20 weight portion, Radix Astragali 20-80 weight portion, Radix Angelicae Sinensis 8-40 weight portion, Cornu Cervi Pantotrichum 5-20 weight portion, Flos Chrysanthemi 40-150 weight portion, Herba Menthae 40-150 weight portion, Radix Bupleuri 40-150 weight portion, Semen Cassiae 40-150 weight portion, Herba Schizonepetae 20-80 weight portion, Radix Salviae Miltiorrhizae 40-150 weight portion, Radix Polygalae 50-200 weight portion, Fructus Schisandrae Chinensis 12-60 weight portion, Semen Ziziphi Spinosae 20-80 weight portion, Plumula Nelumbinis 20-80 weight portion, Radix Ophiopogonis 30-120 weight portion, Bulbus Lilii 30-120 weight portion, Caulis Bambusae In Taenia 10-50 weight portion, Radix Scutellariae 40-150 weight portion, Radix Platycodonis 40-150 weight portion, Pericarpium Citri Reticulatae 10-50 weight portion, Poria 20-80 weight portion, Radix Glycyrrhizae 10-50 weight portion, Rhizoma Pinelliae 10-50 weight portion, Fructus Aurantii 10-50 weight portion, Rhizoma Zingiberis 1-5 weight portion, Gypsum Fibrosum 20-80 weight portion, Borneolum Syntheticum 0.5-4 weight portion, Radix Et Rhizoma Rhei 40-150 weight portion, Caulis Akebiae 5-20 weight portion, Cortex Phellodendri 20-80 weight portion, Semen Platycladi 20-80 weight portion, Semen Nelumbinis 10-50 weight portion, Rhizoma Anemarrhenae 10-50 weight portion, Rhizoma Acori Graminei 40-150 weight portion, Rhizoma Chuanxiong 30-120 weight portion, Radix Paeoniae Rubra 30-120 weight portion, Semen Persicae 30-120 weight portion, Flos Carthami 30-120 weight portion, Fructus Crataegi 40-150 weight portion, Radix Achyranthis Bidentatae 10-50 weight portion, Radix Angelicae Dahuricae 20-80 weight portion, Rhizoma Ligustici 40-150 weight portion, Fructus Viticis 8-40 weight portion, Radix Puerariae 20-80 weight portion, Radix Saposhnikoviae 10-50 weight portion, Rhizoma Et Radix Notopterygii 40-150 weight portion, Ramulus Uncariae Cum Uncis 40-150 weight portion, Radix Rehmanniae 10-50 weight portion.
Wherein, described Cornu Cervi Pantotrichum is peeling Cornu Cervi Pantotrichum; The described Rhizoma Pinelliae is Rhizoma Pinelliae Preparata; Semen Persicae is Semen Persicae (parched).
Chinese medicine composition of the present invention, its crude drug composition is preferably:
Radix Ginseng 8-15 weight portion, Radix Astragali 30-60 weight portion, Radix Angelicae Sinensis 12-30 weight portion, peeling Cornu Cervi Pantotrichum 8-15 weight portion, Flos Chrysanthemi 60-120 weight portion, Herba Menthae 60-120 weight portion, Radix Bupleuri 60-120 weight portion, Semen Cassiae 60-120 weight portion, Herba Schizonepetae 30-60 weight portion, Radix Salviae Miltiorrhizae 60-120 weight portion, Radix Polygalae 80-150 weight portion, Fructus Schisandrae Chinensis 20-50 weight portion, Semen Ziziphi Spinosae 30-60 weight portion, Plumula Nelumbinis 30-60 weight portion, Radix Ophiopogonis 40-90 weight portion, Bulbus Lilii 40-90 weight portion, Caulis Bambusae In Taenia 15-40 weight portion, Radix Scutellariae 60-120 weight portion, Radix Platycodonis 60-120 weight portion, Pericarpium Citri Reticulatae 15-40 weight portion, Poria 30-60 weight portion, Radix Glycyrrhizae 15-40 weight portion, Rhizoma Pinelliae Preparata 15-40 weight portion, Fructus Aurantii 15-40 weight portion, Rhizoma Zingiberis 2-4 weight portion, Gypsum Fibrosum 30-60 weight portion, Borneolum Syntheticum 1-3 weight portion, Radix Et Rhizoma Rhei 60-120 weight portion, Caulis Akebiae 8-15 weight portion, Cortex Phellodendri 30-60 weight portion, Semen Platycladi 30-60 weight portion, Semen Nelumbinis 15-40 weight portion, Rhizoma Anemarrhenae 15-40 weight portion, Rhizoma Acori Graminei 60-120 weight portion, Rhizoma Chuanxiong 40-90 weight portion, Radix Paeoniae Rubra 40-90 weight portion, Semen Persicae (parched) 40-90 weight portion, Flos Carthami 40-90 weight portion, Fructus Crataegi 60-120 weight portion, Radix Achyranthis Bidentatae 15-40 weight portion, Radix Angelicae Dahuricae 30-60 weight portion, Rhizoma Ligustici 60-120 weight portion, Fructus Viticis 12-30 weight portion, Radix Puerariae 30-60 weight portion, Radix Saposhnikoviae 15-40 weight portion, Rhizoma Et Radix Notopterygii 60-120 weight portion, Ramulus Uncariae Cum Uncis 60-120 weight portion, Radix Rehmanniae 15-40 weight portion.
Chinese medicine composition of the present invention, its crude drug composition is preferably:
Radix Ginseng 10 weight portions, the Radix Astragali 40 weight portions, Radix Angelicae Sinensis 15 weight portions, peeling Cornu Cervi Pantotrichum 10 weight portions, Flos Chrysanthemi 80 weight portions, Herba Menthae 80 weight portions, Radix Bupleuri 80 weight portions, Semen Cassiae 80 weight portions, Herba Schizonepetae 40 weight portions, Radix Salviae Miltiorrhizae 80 weight portions, Radix Polygalae 100 weight portions, Fructus Schisandrae Chinensis 25 weight portions, Semen Ziziphi Spinosae 40 weight portions, Plumula Nelumbinis 40 weight portions, Radix Ophiopogonis 60 weight portion, Bulbus Lilii 60 weight portions, Caulis Bambusae In Taenia 20 weight portions, Radix Scutellariae 80 weight portions, Radix Platycodonis 80 weight portions, Pericarpium Citri Reticulatae 20 weight portions, Poria 40 weight portions, Radix Glycyrrhizae 20 weight portions, Rhizoma Pinelliae Preparata 20 weight portions, Fructus Aurantii 20 weight portions, Rhizoma Zingiberis 2.5 weight portions, Gypsum Fibrosum 40 weight portions, Borneolum Syntheticum 2 weight portions, Radix Et Rhizoma Rhei 80 weight portions, Caulis Akebiae 10 weight portions, Cortex Phellodendri 40 weight portions, Semen Platycladi 40 weight portions, Semen Nelumbinis 20 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Rhizoma Acori Graminei 80 weight portions, Rhizoma Chuanxiong 60 weight portions, Radix Paeoniae Rubra 60 weight portions, Semen Persicae (parched) 60 weight portions, Flos Carthami 60 weight portions, Fructus Crataegi 80 weight portions, Radix Achyranthis Bidentatae 20 weight portions, the Radix Angelicae Dahuricae 40 weight portions, Rhizoma Ligustici 80 weight portions, Fructus Viticis 15 weight portions, Radix Puerariae 40 weight portions, Radix Saposhnikoviae 20 weight portions, Rhizoma Et Radix Notopterygii 80 weight portions, Ramulus Uncariae Cum Uncis 80 weight portions, Radix Rehmanniae 20 weight portions.
Chinese medicine composition of the present invention, its crude drug composition is preferably:
Radix Ginseng 8 weight portions, the Radix Astragali 60 weight portions, Radix Angelicae Sinensis 12 weight portions, peeling Cornu Cervi Pantotrichum 15 weight portions, Flos Chrysanthemi 60 weight portions, Herba Menthae 120 weight portions, Radix Bupleuri 60 weight portions, Semen Cassiae 120 weight portions, Herba Schizonepetae 30 weight portions, Radix Salviae Miltiorrhizae 120 weight portions, Radix Polygalae 80 weight portions, Fructus Schisandrae Chinensis 50 weight portions, Semen Ziziphi Spinosae 30 weight portions, Plumula Nelumbinis 60 weight portions, Radix Ophiopogonis 40 weight portion, Bulbus Lilii 90 weight portions, Caulis Bambusae In Taenia 15 weight portions, Radix Scutellariae 120 weight portions, Radix Platycodonis 60 weight portions, Pericarpium Citri Reticulatae 40 weight portions, Poria 30 weight portions, Radix Glycyrrhizae 40 weight portions, Rhizoma Pinelliae Preparata 15 weight portions, Fructus Aurantii 40 weight portions, Rhizoma Zingiberis 2 weight portions, Gypsum Fibrosum 60 weight portions, Borneolum Syntheticum 1 weight portion, Radix Et Rhizoma Rhei 120 weight portions, Caulis Akebiae 8 weight portions, Cortex Phellodendri 60 weight portions, Semen Platycladi 30 weight portions, Semen Nelumbinis 40 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Rhizoma Acori Graminei 120 weight portions, Rhizoma Chuanxiong 40 weight portions, Radix Paeoniae Rubra 90 weight portions, Semen Persicae (parched) 40 weight portions, Flos Carthami 90 weight portions, Fructus Crataegi 60 weight portions, Radix Achyranthis Bidentatae 40 weight portions, the Radix Angelicae Dahuricae 30 weight portions, Rhizoma Ligustici 120 weight portions, Fructus Viticis 12 weight portions, Radix Puerariae 60 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 120 weight portions, Ramulus Uncariae Cum Uncis 60 weight portions, Radix Rehmanniae 40 weight portions.
Chinese medicine composition of the present invention, its crude drug composition is preferably:
Radix Ginseng 15 weight portions, the Radix Astragali 30 weight portions, Radix Angelicae Sinensis 30 weight portions, peeling Cornu Cervi Pantotrichum 8 weight portions, Flos Chrysanthemi 120 weight portions, Herba Menthae 60 weight portions, Radix Bupleuri 120 weight portions, Semen Cassiae 60 weight portions, Herba Schizonepetae 60 weight portions, Radix Salviae Miltiorrhizae 60 weight portions, Radix Polygalae 150 weight portions, Fructus Schisandrae Chinensis 20 weight portions, Semen Ziziphi Spinosae 60 weight portions, Plumula Nelumbinis 30 weight portions, Radix Ophiopogonis 90 weight portion, Bulbus Lilii 40 weight portions, Caulis Bambusae In Taenia 40 weight portions, Radix Scutellariae 60 weight portions, Radix Platycodonis 120 weight portions, Pericarpium Citri Reticulatae 15 weight portions, Poria 60 weight portions, Radix Glycyrrhizae 15 weight portions, Rhizoma Pinelliae Preparata 40 weight portions, Fructus Aurantii 15 weight portions, Rhizoma Zingiberis 4 weight portions, Gypsum Fibrosum 30 weight portions, Borneolum Syntheticum 3 weight portions, Radix Et Rhizoma Rhei 60 weight portions, Caulis Akebiae 15 weight portions, Cortex Phellodendri 30 weight portions, Semen Platycladi 60 weight portions, Semen Nelumbinis 15 weight portions, the Rhizoma Anemarrhenae 40 weight portions, Rhizoma Acori Graminei 60 weight portions, Rhizoma Chuanxiong 90 weight portions, Radix Paeoniae Rubra 40 weight portions, Semen Persicae (parched) 90 weight portions, Flos Carthami 40 weight portions, Fructus Crataegi 120 weight portions, Radix Achyranthis Bidentatae 15 weight portions, the Radix Angelicae Dahuricae 60 weight portions, Rhizoma Ligustici 60 weight portions, Fructus Viticis 30 weight portions, Radix Puerariae 30 weight portions, Radix Saposhnikoviae 40 weight portions, Rhizoma Et Radix Notopterygii 60 weight portions, Ramulus Uncariae Cum Uncis 120 weight portions, Radix Rehmanniae 15 weight portions.
Chinese medicine composition of the present invention can extract and further be processed into clinical acceptable tablet, capsule, granule, pill, oral liquid, powder, syrup according to common process.
Described conventional extraction process comprises by conventional solvent immersion, decoction, backflow or supersound extraction; Can also be further through purification or refining, as crossed macroporous resin column.
The preparation method of Chinese medicine composition of the present invention is:
Get in proportion each crude drug, pulverize, add 6-10 doubly measure (g/m is ethanol l), airtight, 15-30 DEG C soak 20-40 days, filter, get filtrate; Dregs pressing, squeezing juice and filtrate merge, and filter, concentrated, obtain Chinese medicine composition of the present invention.
The preparation method of Chinese medicine composition of the present invention is preferably:
Get in proportion each crude drug, pulverize, (g/m is ethanol l), airtight, and 20 DEG C are soaked 30 days, filter, and get filtrate to add 8 times of amounts; Dregs pressing, squeezing juice and filtrate merge, and filter, concentrated, obtain Chinese medicine composition of the present invention.
For the above-mentioned dosage form of the present invention can be realized, need in the time of these dosage forms of preparation, add the acceptable adjuvant of pharmacy, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are determined, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Research shows, Chinese medicine composition of the present invention has good effect for old mild cognitive impairment, and tcm syndrome curative effect effective percentage is 90.63%, and coefficient of stabilization is 96.88%; Due to aging for cerebral tissue, after hypomnesis treatment, before treatment, there is significant difference (Clinical Memory scale overall score P=0.000).
Experimental example 1
1. clinical data
This research case all derives from July, 2011 to 2011 year December Chengdu South Railway Station community hospital outpatient service, finally observes MC I patient 32 examples, wherein male 11 examples, and female's 21 examples, the age is in 55-78 year, 68.93 ± 6.53 years old mean age; The course of disease is the shortest 0.5 year, the longest 10 years, average course of disease 6.72 ± 3.07 years; Average height 158 ± 7.62 ㎝, average weight 64.25 ± 10.96 ㎏; 10 people of schooling primary school, the people of junior middle schools 12, senior middle school and above academic 10 people; Dextromanuality 30 people, left handedness 2 people; Physical work 23 people, comprise workman, peasant, soldier etc., and non-manual work 9 people comprise management, accounting, pilot etc.; Sick 13 people of complicated hypertension, coronary heart disease 1 people, hyperlipidemia 1 people, insomnia medical history 15 people, have smoking, history of drinking history 8 people.
Diagnostic criteria:
1. MCI diagnostic criteria { the Petersen RC proposing with reference to Petersen etc., Smith GE & Waring SC, et a1.Mild cognitive impairment:Clinical characterization and outcome[J] .Arch Neurol, 1999,56:303-308.}: the main suit of the hypomnesis being provided by me, family members or insider is provided patient; There is the objective evidence (memory decline degree lower than age and the contrast of culture coupling 1.5 more than standard deviation) of hypomnesis; Basic daily behavior ability is without significantly damaged; Get rid of dement or any body or mental sickness that can cause functional disorders of brain.
Specifically comprise following some: main suit's hypomnesis, and through other people confirm; Clinical Memory scale obtains proportion by subtraction age and at least low 1.5 standard deviations of education coupling crowd; Simple and easy mental status scale scoring (MMSE) must be divided into 24～27 points; 2 points of 1 point of activities of daily living scale score (ADL) < or IADL <; Vision and audition resolving power still can be accepted neuropsychology test; ≤ 20 points of overall decline scale scorings.
2. MCI traditional Chinese medical science disease type diagnostic criteria: possess two of following main symptoms (hypophrenia indispensability), it can clinical syndrome differentiation be shenxu-tanyu card that another time card at least possesses more than 2 person.
Primary symptom: hypophrenia, soreness of the waist and knees, asthenia is thought sleeping, heaviness of the head as if it were tightly bandaged, abundant expectoration salivation, dim complexion or lip onyx are livid purple.
Inferior disease: bradyphrenia, vertigo and tinnitus, fat too fat to move, pain in fixed position, soon blue or green black, urinary incontinence.
2. therapeutic scheme
Get oral liquid prepared by embodiment 1, each 10ml, every day 2 times.12 weeks courses for the treatment of.Respectively at before medication, record scoring in the 1st, 4,8,12 weeks.Before and after medication, respectively make 1 part of Clinical Memory scale.
3. observation of curative effect
3.1 efficacy evaluation indexs
3.1.1 cognitive competence:
Adopt simple and easy Mental status schedule (MMSE) scoring;
Memory function (adopting Clinical Memory scale) scoring;
Carry out functional assessment (trail making test A-B scale) scoring;
3.1.2 activity of daily living:
Activities of daily living scale (ADL) scoring;
3.1.3 syndrome and somatic feature score: symptom and sign scalar quantization table are as shown in table 1:
Table 1 MCI shenxu-tanyu symptom and sign scalar quantization table
3.2 health giving quality evaluations
Therapeutic effect of syndrome criterion:
Calculate therapeutic index, carry out tcm syndrome therapeutic evaluation according to therapeutic index.
Integration × 100% before therapeutic index=(the front integration of integration-treatment after treatment)/treatment
Tcm syndrome curative effect:
Clinical recovery: therapeutic index >=80%, patient's symptom, sign disappear or substantially disappear;
Effective: 50%≤therapeutic index < 80%, symptom, sign are obviously improved;
Progressive: 20%≤therapeutic index < 50%, symptom, sign all take a turn for the better;
Without regressing: 0≤therapeutic index < 20%, symptom, sign are without significant change;
Invalid: therapeutic index < 0%, symptom, sign increase the weight of.
Effective percentage (%)=(recovery from illness number+effective number+progress number)/total number of persons
Coefficient of stabilization (%)=(recovery from illness number+effective number+progress number+without room for manoeuvre number)/total number of persons
4. statistical method
Adopt SPSS l 3.0 statistical analysis softwares to carry out statistical procedures, measurement data data all adopt mean ± standard deviation
quantitative data meets paired t-test for normal distribution (carry out homogeneity test of variance between group, using 0.05 as inspection level, the t proofreading and correct when heterogeneity of variance checks), does not meet normal distribution rank test.Using P≤0.05, as there being significance statistical significance, P ﹤ 0.01 is significant differences.
5. result
5.1 therapeutic effect of syndrome analysis results
According to syndrome integration method, obtain syndrome integration, and respectively before medication, 1 week, 4 weeks, 8 weeks, 12 weeks records respectively after medication.Measurement data all adopts mean ± standard deviation
represent, adopt paired t-test, the results are shown in Table 2:
After table 2 oral liquid treatment MCI of the present invention with treatment before the comparison of syndrome total mark
Record gained syndrome total mark respectively with medication before the comparison of syndrome total mark, adopt paired t-test, result show, treat after 1 week, P=0.015, has significant difference; After treatment January, after February, after March with medication before relatively, P value is equal to=0.000, has statistical significance.
According to cardinal symptom integration method, obtain cardinal symptom total mark, and respectively before medication, 1 week, 4 weeks, 8 weeks, 12 weeks records respectively after medication.Measurement data all adopts mean ± standard deviation
represent, adopt Wilcoxon paired test, the results are shown in Table 3:
Cardinal symptom total mark comparison before and after table 3 oral liquid treatment MCI of the present invention
After treatment before and after cardinal symptom scoring relatively, taking bilateral P value 0.05 as standard, significant difference is obvious, evident in efficacy, medication, after one week, starts onset P=0.023, after medication January, just has significant curative effect.
Before medication with after medication March, record respectively every symptom integral, adopt Wilcoxon paired test, observe each cardinal symptom curative effect and change, the results are shown in Table 4:
Before table 4 oral liquid treatment MCI of the present invention with March after cardinal symptom individual event integral contrast
In table 4, before and after treatment, soreness of the waist and knees symptom integral P=0.000, tired state are thought sleeping P=0.013, heaviness of the head as if it were tightly bandaged P=0.0000, abundant expectoration salivation P=0.003, dim complexion P=0.024, taking bilateral P value 0.05 as standard, significant difference is obvious, and there were significant differences for treatment integration; Hypophrenia P=0.135, the livid purple P=0.076 of lip onyx, taking bilateral P value 0.05 as standard, statistics is without significant difference.
By above-mentioned the standard of curative effect evaluation, evaluation medication oral liquid Efficacy of Traditional Chinese Medicine of the present invention after 3 months, the results are shown in Table 5:
Table 5 take medicine 3 months after tcm syndrome efficacy result
5.2 cognitive function curative effect evaluations
After medication 3 months, the overall cognitive level of patient is changed and assessed, respectively MMSE scale (overall cognitive function), Clinical Memory scale (memory), line detection (execution function), ADL scale activity of daily living are assessed.
MMSE scale is used for evaluating overall cognitive function, can be divided into the junior units such as orientation force, memory, linguistic competence, but except directional memory, and other are every can not represent the cognitive function in corresponding field separately.The results are shown in Table 6.
Before and after table 6 medication, MMSE scoring relatively
After treatment, orientation force integration is significantly improved before treating, and through the bilateral P=0.007 of Wilcoxon paired test, obtains P < 0.05, variant before and after the treatment of orientation force integration; MMSE scale total mark, through Wilcoxon paired test, obtains bilateral P=0.000, and P < 0.05 thinks that MMSE total score treatment front and back are variant.
Clinical Memory scale, for the main scale of observing of this research, for evaluating memory level, frees recall comprising sensing memory, learning by association, image etc.The results are shown in Table 7.
The Clinical Memory scale scoring of table 7 medication front and back in March relatively
Before and after treatment, Clinical Memory scale overall score adopts Wilcoxon paired test, bilateral P=0.000, and P < 0.05 illustrates that Clinical Memory scale total score treatment front and back are variant, evident in efficacy.Sensing memory, image are freed recall, random shape is re-recognized scoring and all adopted the bilateral P=0.000 of Wilcoxon paired test or 0.034, the equal < 0.05 of P, illustrate that sensing memory scoring, image are freed recall, random shape is re-recognized scoring treatment front and back variant, evident in efficacy.Learning by association, portrait feature contact memory all adopt paired t-test, and result shows the equal > 0.05 of P, no difference of science of statistics.
Trail making test assess patient is carried out function, is divided into A and B two parts, and A part reflects consciousness movement velocity, and B part is except comprising consciousness movement velocity, also comprises concept and attention switching ability, and to frontal lobe, hypokinetic screening has certain help.The results are shown in Table 8.
The trail making test A-B scale scoring of table 8 medication front and back in March relatively
Before and after treatment, trail making test A and B all adopt paired t-test, and A part P value is less than 0.05, and before and after treatment, there were significant differences, and B part P=0.69, is greater than 0.05, no difference of science of statistics.
The comparison of activity of daily living curative effect
Daily living measuring scale comprises basic activity of daily living and complicated activity of daily living, and the latter can identify MCI, application paired t-test, and result shows that before and after treatment, there were significant differences, evident in efficacy.The results are shown in Table 9.
Before and after table 9 medication, the scoring of ADL scale relatively
Detailed description of the invention
Embodiment 1 oral liquid
Prescription:
Radix Ginseng 10g, Radix Astragali 40g, Radix Angelicae Sinensis 15g, Cornu Cervi Pantotrichum (peeling) 10g, Flos Chrysanthemi 80g, Herba Menthae 80g, Radix Bupleuri 80g, Semen Cassiae 80g, Herba Schizonepetae 40g, Radix Salviae Miltiorrhizae 80g, Radix Polygalae 100g, Fructus Schisandrae Chinensis 25g, Semen Ziziphi Spinosae 40g, Plumula Nelumbinis 40g, Radix Ophiopogonis 60g, Bulbus Lilii 60g, Caulis Bambusae In Taenia 20g, Radix Scutellariae 80g, Radix Platycodonis 80g, Pericarpium Citri Reticulatae 20g, Poria 40g, Radix Glycyrrhizae 20g, Rhizoma Pinelliae (processed) 20g, Fructus Aurantii 20g, Rhizoma Zingiberis 2.5g, Gypsum Fibrosum 40g, Borneolum Syntheticum 2g, Radix Et Rhizoma Rhei 80g, Caulis Akebiae 10g, Cortex Phellodendri 40g, Semen Platycladi 40g, Semen Nelumbinis 20g, Rhizoma Anemarrhenae 20g, Rhizoma Acori Graminei 80g, Rhizoma Chuanxiong 60g, Radix Paeoniae Rubra 60g, Semen Persicae (stir-fry) 60g, Flos Carthami 60g, Fructus Crataegi 80g, Radix Achyranthis Bidentatae 20g, Radix Angelicae Dahuricae 40g, Rhizoma Ligustici 80g, Fructus Viticis 15g, Radix Puerariae 40g, Radix Saposhnikoviae 20g, Rhizoma Et Radix Notopterygii 80g, Ramulus Uncariae Cum Uncis 80g, Radix Rehmanniae 20g,
Preparation method:
Above 48 tastes, are ground into coarse powder, add 8 times of amount ethanol, and airtight, 20 DEG C are soaked 30 days, filter, and get filtrate; Dregs pressing, squeezing juice and filtrate merge, and filter; Add the correctives such as white sugar, Mel appropriate, be stirred to dissolve, airtight standing 15 days, make altogether 10000ml, filter, subpackage, to obtain final product.
Usage and consumption: oral, every day 2 times, each 10ml.
Specification: every 10ml.
Embodiment 2 tablets
Prescription:
Radix Ginseng 8g, Radix Astragali 60g, Radix Angelicae Sinensis 12g, Cornu Cervi Pantotrichum (peeling) 15g, Flos Chrysanthemi 60g, Herba Menthae 120g, Radix Bupleuri 60g, Semen Cassiae 120g, Herba Schizonepetae 30g, Radix Salviae Miltiorrhizae 120g, Radix Polygalae 80g, Fructus Schisandrae Chinensis 50g, Semen Ziziphi Spinosae 30g, Plumula Nelumbinis 60g, Radix Ophiopogonis 40g, Bulbus Lilii 90g, Caulis Bambusae In Taenia 15g, Radix Scutellariae 120g, Radix Platycodonis 60g, Pericarpium Citri Reticulatae 40g, Poria 30g, Radix Glycyrrhizae 40g, Rhizoma Pinelliae (processed) 15g, Fructus Aurantii 40g, Rhizoma Zingiberis 2g, Gypsum Fibrosum 60g, Borneolum Syntheticum 1g, Radix Et Rhizoma Rhei 120g, Caulis Akebiae 8g, Cortex Phellodendri 60g, Semen Platycladi 30g, Semen Nelumbinis 40g, Rhizoma Anemarrhenae 15g, Rhizoma Acori Graminei 120g, Rhizoma Chuanxiong 40g, Radix Paeoniae Rubra 90g, Semen Persicae (stir-fry) 40g, Flos Carthami 90g, Fructus Crataegi 60g, Radix Achyranthis Bidentatae 40g, Radix Angelicae Dahuricae 30g, Rhizoma Ligustici 120g, Fructus Viticis 12g, Radix Puerariae 60g, Radix Saposhnikoviae 15g, Rhizoma Et Radix Notopterygii 120g, Ramulus Uncariae Cum Uncis 60g, Radix Rehmanniae 40g,
Preparation method:
Above 48 tastes, add 10 times of water gagings and decoct 2 times, 2h for the first time, and 1.5h for the second time, merge extractive liquid,, filters, and filtrate is concentrated, adds lactose, starch, magnesium stearate appropriate, makes according to a conventional method tablet.
Embodiment 3 granules
Prescription:
Radix Ginseng 15g, Radix Astragali 30g, Radix Angelicae Sinensis 30g, Cornu Cervi Pantotrichum (peeling) 8g, Flos Chrysanthemi 120g, Herba Menthae 60g, Radix Bupleuri 120g, Semen Cassiae 60g, Herba Schizonepetae 60g, Radix Salviae Miltiorrhizae 60g, Radix Polygalae 150g, Fructus Schisandrae Chinensis 20g, Semen Ziziphi Spinosae 60g, Plumula Nelumbinis 30g, Radix Ophiopogonis 90g, Bulbus Lilii 40g, Caulis Bambusae In Taenia 40g, Radix Scutellariae 60g, Radix Platycodonis 120g, Pericarpium Citri Reticulatae 15g, Poria 60g, Radix Glycyrrhizae 15g, Rhizoma Pinelliae (processed) 40g, Fructus Aurantii 15g, Rhizoma Zingiberis 4g, Gypsum Fibrosum 30g, Borneolum Syntheticum 3g, Radix Et Rhizoma Rhei 60g, Caulis Akebiae 15g, Cortex Phellodendri 30g, Semen Platycladi 60g, Semen Nelumbinis 15g, Rhizoma Anemarrhenae 40g, Rhizoma Acori Graminei 60g, Rhizoma Chuanxiong 90g, Radix Paeoniae Rubra 40g, Semen Persicae (stir-fry) 90g, Flos Carthami 40g, Fructus Crataegi 120g, Radix Achyranthis Bidentatae 15g, Radix Angelicae Dahuricae 60g, Rhizoma Ligustici 60g, Fructus Viticis 30g, Radix Puerariae 30g, Radix Saposhnikoviae 40g, Rhizoma Et Radix Notopterygii 60g, Ramulus Uncariae Cum Uncis 120g, Radix Rehmanniae 15g,
Preparation method:
Above 48 tastes, add 6 times of amount alcohol reflux 3 times, 2h for the first time, and second and third each 1h, merge extractive liquid,, filters, and filtrate is concentrated, adds lactose, starch, magnesium stearate appropriate, granulation agent according to a conventional method.
Embodiment 4 powders
Prescription:
Radix Ginseng 12g, Radix Astragali 40g, Radix Angelicae Sinensis 25g, Cornu Cervi Pantotrichum (peeling) 9g, Flos Chrysanthemi 110g, Herba Menthae 70g, Radix Bupleuri 100g, Semen Cassiae 70g, Herba Schizonepetae 55g, Radix Salviae Miltiorrhizae 80g, Radix Polygalae 130g, Fructus Schisandrae Chinensis 25g, Semen Ziziphi Spinosae 50g, Plumula Nelumbinis 35g, Radix Ophiopogonis 75g, Bulbus Lilii 50g, Caulis Bambusae In Taenia 30g, Radix Scutellariae 70g, Radix Platycodonis 100g, Pericarpium Citri Reticulatae 18g, Poria 55g, Radix Glycyrrhizae 20g, Rhizoma Pinelliae (processed) 35g, Fructus Aurantii 18g, Rhizoma Zingiberis 3g, Gypsum Fibrosum 35g, Borneolum Syntheticum 3g, Radix Et Rhizoma Rhei 80g, Caulis Akebiae 12g, Cortex Phellodendri 40g, Semen Platycladi 55g, Semen Nelumbinis 20g, Rhizoma Anemarrhenae 35g, Rhizoma Acori Graminei 70g, Rhizoma Chuanxiong 80g, Radix Paeoniae Rubra 50g, Semen Persicae (stir-fry) 85g, Flos Carthami 55g, Fructus Crataegi 110g, Radix Achyranthis Bidentatae 25g, Radix Angelicae Dahuricae 50g, Rhizoma Ligustici 70g, Fructus Viticis 25g, Radix Puerariae 40g, Radix Saposhnikoviae 35g, Rhizoma Et Radix Notopterygii 70g, Ramulus Uncariae Cum Uncis 100g, Radix Rehmanniae 20g,
Preparation method:
Above 48 tastes, are ground into coarse powder, add 10 ethanol, airtight, and 25 DEG C are soaked 20 days, filter, and get filtrate; Dregs pressing, squeezing juice and filtrate merge, and filter, concentrated; Extract extractum adds conventional adjuvant to make powder according to common process.
Claims (10)
1. the application of Chinese medicine composition in the old mild cognitive impairment medicine of preparation treatment, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 5-20 weight portion, Radix Astragali 20-80 weight portion, Radix Angelicae Sinensis 8-40 weight portion, Cornu Cervi Pantotrichum 5-20 weight portion, Flos Chrysanthemi 40-150 weight portion, Herba Menthae 40-150 weight portion, Radix Bupleuri 40-150 weight portion, Semen Cassiae 40-150 weight portion, Herba Schizonepetae 20-80 weight portion, Radix Salviae Miltiorrhizae 40-150 weight portion, Radix Polygalae 50-200 weight portion, Fructus Schisandrae Chinensis 12-60 weight portion, Semen Ziziphi Spinosae 20-80 weight portion, Plumula Nelumbinis 20-80 weight portion, Radix Ophiopogonis 30-120 weight portion, Bulbus Lilii 30-120 weight portion, Caulis Bambusae In Taenia 10-50 weight portion, Radix Scutellariae 40-150 weight portion, Radix Platycodonis 40-150 weight portion, Pericarpium Citri Reticulatae 10-50 weight portion, Poria 20-80 weight portion, Radix Glycyrrhizae 10-50 weight portion, Rhizoma Pinelliae 10-50 weight portion, Fructus Aurantii 10-50 weight portion, Rhizoma Zingiberis 1-5 weight portion, Gypsum Fibrosum 20-80 weight portion, Borneolum Syntheticum 0.5-4 weight portion, Radix Et Rhizoma Rhei 40-150 weight portion, Caulis Akebiae 5-20 weight portion, Cortex Phellodendri 20-80 weight portion, Semen Platycladi 20-80 weight portion, Semen Nelumbinis 10-50 weight portion, Rhizoma Anemarrhenae 10-50 weight portion, Rhizoma Acori Graminei 40-150 weight portion, Rhizoma Chuanxiong 30-120 weight portion, Radix Paeoniae Rubra 30-120 weight portion, Semen Persicae 30-120 weight portion, Flos Carthami 30-120 weight portion, Fructus Crataegi 40-150 weight portion, Radix Achyranthis Bidentatae 10-50 weight portion, Radix Angelicae Dahuricae 20-80 weight portion, Rhizoma Ligustici 40-150 weight portion, Fructus Viticis 8-40 weight portion, Radix Puerariae 20-80 weight portion, Radix Saposhnikoviae 10-50 weight portion, Rhizoma Et Radix Notopterygii 40-150 weight portion, Ramulus Uncariae Cum Uncis 40-150 weight portion, Radix Rehmanniae 10-50 weight portion.
2. application as claimed in claim 1, wherein said Cornu Cervi Pantotrichum is peeling Cornu Cervi Pantotrichum; The described Rhizoma Pinelliae is Rhizoma Pinelliae Preparata; Semen Persicae is Semen Persicae (parched).
3. application as claimed in claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 8-15 weight portion, Radix Astragali 30-60 weight portion, Radix Angelicae Sinensis 12-30 weight portion, peeling Cornu Cervi Pantotrichum 8-15 weight portion, Flos Chrysanthemi 60-120 weight portion, Herba Menthae 60-120 weight portion, Radix Bupleuri 60-120 weight portion, Semen Cassiae 60-120 weight portion, Herba Schizonepetae 30-60 weight portion, Radix Salviae Miltiorrhizae 60-120 weight portion, Radix Polygalae 80-150 weight portion, Fructus Schisandrae Chinensis 20-50 weight portion, Semen Ziziphi Spinosae 30-60 weight portion, Plumula Nelumbinis 30-60 weight portion, Radix Ophiopogonis 40-90 weight portion, Bulbus Lilii 40-90 weight portion, Caulis Bambusae In Taenia 15-40 weight portion, Radix Scutellariae 60-120 weight portion, Radix Platycodonis 60-120 weight portion, Pericarpium Citri Reticulatae 15-40 weight portion, Poria 30-60 weight portion, Radix Glycyrrhizae 15-40 weight portion, Rhizoma Pinelliae Preparata 15-40 weight portion, Fructus Aurantii 15-40 weight portion, Rhizoma Zingiberis 2-4 weight portion, Gypsum Fibrosum 30-60 weight portion, Borneolum Syntheticum 1-3 weight portion, Radix Et Rhizoma Rhei 60-120 weight portion, Caulis Akebiae 8-15 weight portion, Cortex Phellodendri 30-60 weight portion, Semen Platycladi 30-60 weight portion, Semen Nelumbinis 15-40 weight portion, Rhizoma Anemarrhenae 15-40 weight portion, Rhizoma Acori Graminei 60-120 weight portion, Rhizoma Chuanxiong 40-90 weight portion, Radix Paeoniae Rubra 40-90 weight portion, Semen Persicae (parched) 40-90 weight portion, Flos Carthami 40-90 weight portion, Fructus Crataegi 60-120 weight portion, Radix Achyranthis Bidentatae 15-40 weight portion, Radix Angelicae Dahuricae 30-60 weight portion, Rhizoma Ligustici 60-120 weight portion, Fructus Viticis 12-30 weight portion, Radix Puerariae 30-60 weight portion, Radix Saposhnikoviae 15-40 weight portion, Rhizoma Et Radix Notopterygii 60-120 weight portion, Ramulus Uncariae Cum Uncis 60-120 weight portion, Radix Rehmanniae 15-40 weight portion.
4. application as claimed in claim 3, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 10 weight portions, the Radix Astragali 40 weight portions, Radix Angelicae Sinensis 15 weight portions, peeling Cornu Cervi Pantotrichum 10 weight portions, Flos Chrysanthemi 80 weight portions, Herba Menthae 80 weight portions, Radix Bupleuri 80 weight portions, Semen Cassiae 80 weight portions, Herba Schizonepetae 40 weight portions, Radix Salviae Miltiorrhizae 80 weight portions, Radix Polygalae 100 weight portions, Fructus Schisandrae Chinensis 25 weight portions, Semen Ziziphi Spinosae 40 weight portions, Plumula Nelumbinis 40 weight portions, Radix Ophiopogonis 60 weight portion, Bulbus Lilii 60 weight portions, Caulis Bambusae In Taenia 20 weight portions, Radix Scutellariae 80 weight portions, Radix Platycodonis 80 weight portions, Pericarpium Citri Reticulatae 20 weight portions, Poria 40 weight portions, Radix Glycyrrhizae 20 weight portions, Rhizoma Pinelliae Preparata 20 weight portions, Fructus Aurantii 20 weight portions, Rhizoma Zingiberis 2.5 weight portions, Gypsum Fibrosum 40 weight portions, Borneolum Syntheticum 2 weight portions, Radix Et Rhizoma Rhei 80 weight portions, Caulis Akebiae 10 weight portions, Cortex Phellodendri 40 weight portions, Semen Platycladi 40 weight portions, Semen Nelumbinis 20 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Rhizoma Acori Graminei 80 weight portions, Rhizoma Chuanxiong 60 weight portions, Radix Paeoniae Rubra 60 weight portions, Semen Persicae (parched) 60 weight portions, Flos Carthami 60 weight portions, Fructus Crataegi 80 weight portions, Radix Achyranthis Bidentatae 20 weight portions, the Radix Angelicae Dahuricae 40 weight portions, Rhizoma Ligustici 80 weight portions, Fructus Viticis 15 weight portions, Radix Puerariae 40 weight portions, Radix Saposhnikoviae 20 weight portions, Rhizoma Et Radix Notopterygii 80 weight portions, Ramulus Uncariae Cum Uncis 80 weight portions, Radix Rehmanniae 20 weight portions.
5. application as claimed in claim 3, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 8 weight portions, the Radix Astragali 60 weight portions, Radix Angelicae Sinensis 12 weight portions, peeling Cornu Cervi Pantotrichum 15 weight portions, Flos Chrysanthemi 60 weight portions, Herba Menthae 120 weight portions, Radix Bupleuri 60 weight portions, Semen Cassiae 120 weight portions, Herba Schizonepetae 30 weight portions, Radix Salviae Miltiorrhizae 120 weight portions, Radix Polygalae 80 weight portions, Fructus Schisandrae Chinensis 50 weight portions, Semen Ziziphi Spinosae 30 weight portions, Plumula Nelumbinis 60 weight portions, Radix Ophiopogonis 40 weight portion, Bulbus Lilii 90 weight portions, Caulis Bambusae In Taenia 15 weight portions, Radix Scutellariae 120 weight portions, Radix Platycodonis 60 weight portions, Pericarpium Citri Reticulatae 40 weight portions, Poria 30 weight portions, Radix Glycyrrhizae 40 weight portions, Rhizoma Pinelliae Preparata 15 weight portions, Fructus Aurantii 40 weight portions, Rhizoma Zingiberis 2 weight portions, Gypsum Fibrosum 60 weight portions, Borneolum Syntheticum 1 weight portion, Radix Et Rhizoma Rhei 120 weight portions, Caulis Akebiae 8 weight portions, Cortex Phellodendri 60 weight portions, Semen Platycladi 30 weight portions, Semen Nelumbinis 40 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Rhizoma Acori Graminei 120 weight portions, Rhizoma Chuanxiong 40 weight portions, Radix Paeoniae Rubra 90 weight portions, Semen Persicae (parched) 40 weight portions, Flos Carthami 90 weight portions, Fructus Crataegi 60 weight portions, Radix Achyranthis Bidentatae 40 weight portions, the Radix Angelicae Dahuricae 30 weight portions, Rhizoma Ligustici 120 weight portions, Fructus Viticis 12 weight portions, Radix Puerariae 60 weight portions, Radix Saposhnikoviae 15 weight portions, Rhizoma Et Radix Notopterygii 120 weight portions, Ramulus Uncariae Cum Uncis 60 weight portions, Radix Rehmanniae 40 weight portions.
6. application as claimed in claim 3, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Radix Ginseng 15 weight portions, the Radix Astragali 30 weight portions, Radix Angelicae Sinensis 30 weight portions, peeling Cornu Cervi Pantotrichum 8 weight portions, Flos Chrysanthemi 120 weight portions, Herba Menthae 60 weight portions, Radix Bupleuri 120 weight portions, Semen Cassiae 60 weight portions, Herba Schizonepetae 60 weight portions, Radix Salviae Miltiorrhizae 60 weight portions, Radix Polygalae 150 weight portions, Fructus Schisandrae Chinensis 20 weight portions, Semen Ziziphi Spinosae 60 weight portions, Plumula Nelumbinis 30 weight portions, Radix Ophiopogonis 90 weight portion, Bulbus Lilii 40 weight portions, Caulis Bambusae In Taenia 40 weight portions, Radix Scutellariae 60 weight portions, Radix Platycodonis 120 weight portions, Pericarpium Citri Reticulatae 15 weight portions, Poria 60 weight portions, Radix Glycyrrhizae 15 weight portions, Rhizoma Pinelliae Preparata 40 weight portions, Fructus Aurantii 15 weight portions, Rhizoma Zingiberis 4 weight portions, Gypsum Fibrosum 30 weight portions, Borneolum Syntheticum 3 weight portions, Radix Et Rhizoma Rhei 60 weight portions, Caulis Akebiae 15 weight portions, Cortex Phellodendri 30 weight portions, Semen Platycladi 60 weight portions, Semen Nelumbinis 15 weight portions, the Rhizoma Anemarrhenae 40 weight portions, Rhizoma Acori Graminei 60 weight portions, Rhizoma Chuanxiong 90 weight portions, Radix Paeoniae Rubra 40 weight portions, Semen Persicae (parched) 90 weight portions, Flos Carthami 40 weight portions, Fructus Crataegi 120 weight portions, Radix Achyranthis Bidentatae 15 weight portions, the Radix Angelicae Dahuricae 60 weight portions, Rhizoma Ligustici 60 weight portions, Fructus Viticis 30 weight portions, Radix Puerariae 30 weight portions, Radix Saposhnikoviae 40 weight portions, Rhizoma Et Radix Notopterygii 60 weight portions, Ramulus Uncariae Cum Uncis 120 weight portions, Radix Rehmanniae 15 weight portions.
7. the application as described in as arbitrary in claim 1-6, is characterized in that described Chinese medicine composition can extract and further be processed into clinical acceptable tablet, capsule, granule, pill, oral liquid, powder, syrup according to common process.
8. the application as described in as arbitrary in claim 1-6, is characterized in that the preparation method of described Chinese medicine composition is:
Get in proportion each crude drug, pulverize, add 6-10 doubly to measure ethanol, airtight, 15-30 DEG C is soaked 20-40 days, filters, and gets filtrate; Dregs pressing, squeezing juice and filtrate merge, and filter, concentrated, obtain described Chinese medicine composition.
9. application as claimed in claim 1, is characterized in that, this Chinese medicine composition improves the application in consciousness movement velocity medicine in preparation.
10. application as claimed in claim 1, is characterized in that, this Chinese medicine composition improves the application in activity of daily living medicine in preparation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547335A (en) * | 2015-02-05 | 2015-04-29 | 韦邦力 | Traditional Chinese medicine composition for treating senile dementia |
| CN105748942A (en) * | 2016-03-23 | 2016-07-13 | 邱延昭 | Traditional Chinese medicine composition for treating ocular inflammations and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103566087B (en) * | 2013-10-17 | 2017-04-12 | 宇特金 | Pharmaceutical composition for treating cognitive disorder and application thereof in preparation of medicine for treating Alzheimer disease |
| SG10201507607RA (en) * | 2015-09-14 | 2017-04-27 | Moleac Pte Ltd | Process For Producing Traditional Chinese Medicine Compositions, And Compositions Obtainable By The Process |
| WO2017104706A1 (en) * | 2015-12-18 | 2017-06-22 | 国立大学法人 富山大学 | Agent and composition for inducing expression of brain-derived neurotrophic factor |
| CN105816740A (en) * | 2016-06-09 | 2016-08-03 | 童松 | Brain-tonifying liquor capable of eliminating dampness and phlegm |
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| CN1872329A (en) * | 2005-06-03 | 2006-12-06 | 天津天士力制药股份有限公司 | Application of medication composition of containing giant gen-seng in preparing medicine for treating insufficiency of blood supply for brain |
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| CN1872329A (en) * | 2005-06-03 | 2006-12-06 | 天津天士力制药股份有限公司 | Application of medication composition of containing giant gen-seng in preparing medicine for treating insufficiency of blood supply for brain |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547335A (en) * | 2015-02-05 | 2015-04-29 | 韦邦力 | Traditional Chinese medicine composition for treating senile dementia |
| CN105748942A (en) * | 2016-03-23 | 2016-07-13 | 邱延昭 | Traditional Chinese medicine composition for treating ocular inflammations and preparation method thereof |
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