CN102716313A - Anti-dairy cow transport stress pharmaceutical composition - Google Patents
Anti-dairy cow transport stress pharmaceutical composition Download PDFInfo
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- CN102716313A CN102716313A CN2012102322528A CN201210232252A CN102716313A CN 102716313 A CN102716313 A CN 102716313A CN 2012102322528 A CN2012102322528 A CN 2012102322528A CN 201210232252 A CN201210232252 A CN 201210232252A CN 102716313 A CN102716313 A CN 102716313A
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Abstract
The invention aims to provide an anti-dairy cow transport stress pharmaceutical composition, which comprises the following crude drugs in parts by weight: 80-100g of spina date seed, 25-30g of Poria cocos, 15-20g of polygala tenuifolia, 15-20g of rhizoma anemarrhenae, 20-30g of jasmine, 10-20g of Scutellaria baicalensis, 5-10g of ossa draconis and 10-20g of oyster. Through experimental studies, the composition provided by the invention is capable of effectively preventing the blood sugar concentration of dairy cows under the stress state from rising and restraining the rise of the concentration of adrenocortical hormone and the concentration of lactic dehydrogenase, so, hearts and livers are prevented from being damaged. The anti-dairy cow transport stress pharmaceutical composition is convenient to use, i.e., the anti-dairy cow transport stress pharmaceutical composition only needs to be blended into a feed in an amount converted from the weights of the dairy cows. The anti-dairy cow transport stress pharmaceutical composition is expected to be developed to become a novel anti-stress pharmaceutical preparation product used before the dairy cow is transported.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of anti-stress,, belong to Chinese medicine veterinary drug preparation technical field especially as the pharmaceutical composition of the anti-milch cow transport stress of preparation.
Background technology
Transport stress is meant hungering and thirst in transit, mixes the crowd, crowded, high temperature, jolt, under the comprehensive function of stressors such as noise, fatigue, mental pressure, physiological adaption reaction that the milch cow body produces and pathology variation.Transport stress causes intravital nutrition, moisture lot of consumption, finally causes body weight loss, milk crop, quality reduction, immunity reduction etc.This causes people's great attention, takes different measures to regulate and control.
1, Western medicine regulation and control stress mainly is a nervous system regulation class medicine; Like sedative hypnotic, anxiolytic drugs, anticonvulsant and antidepressant; Wherein apparent in view with tricyclic antidepressants antidepressant and oxidase inhibitor effect, selective serotonin reuptake inhibitor also has regulating effect preferably.Mainly be the control neuroendocrine, reduce animal over alertness symptom, avoid the infringement of transport stress.But animal often produces dependency to nervous system class medicine, and it is residual to be prone to produce medicine, harm milch cow and health.
2, traditional Chinese medicine theory thought by force or stress of a specified duration excessively often unfavorable and cause damage to body, all should suppress.Such as behind mouse peritoneal injection ginsenoside, stress obviously weaken, because the rising of the blood plasma adrenal gland aldosterone level of stress induction, this effect is mainly through active realization of blocking-up adrenal gland ACTH.Therefore, the ginsenoside is considered to have the effect that treatment stress related disorder; The rat that carries out 6 all increasing load training is given the Ginsengdiol histsaponin and the Ginsengdiol histsaponin of methyltestosterone and various dose; The high dose group serum testosterone raises the most obvious; Possibly be that Ginsengdiol histsaponin passes through GTH appearance effect promotion hypophysis secreted glandular hormone-lutropin; The HPG axle is reconciled at many levels the obvious reduction of testosterone when correcting large amount of exercise.Also there is the report Herba Epimedii can stimulate male rabbit to strengthen secretory action, improves the content of testosterone, improve of the adjusting of organism endocrine system the HPG axle to testosterone.So combine the transport stress genesis mechanism, the Chinese medicinal formulae that screening is best is a prerequisite of using Chinese medicine control transport stress.It is presently believed that Chinese medicine belongs to low-residual, low cytotoxic drug, do not find that as yet animal produces dependency to Chinese medicine, there is not secondary pollution in livestock products, cattle and people's health are not all had influence.
3, stress can produce destructive effects to the release of the adrenocortical hormone-hydrocortisone of body normal rhythm property.Experiment finds, nutritional substances such as the coenzyme of vitamin C, vitamin B1, vitamin B12 (methylcobalamin), tyrosine, Phosphatidylserine can both promote body to stress producing adaptation response, and reduces the general reaction that stress cause.Existing evidence shows, takes in the vitamin C of Duoing than the recommended dietary nutrient allowance and helps to adjust the pure and mild ACTH level of plasma corticosterone, makes it normalization.Nutritional substances such as the preceding vitamin C of feeding to cattle of transportation can be alleviated transport stress to a certain extent, but effect is obvious not as veterinary drug.
4, research shows that persistent medium and small load exercise training can regulate the hydrocortisone excessive secretion that psychological stress causes; Improve the adaptability of hpa axis; Its sensitivity to GC in the blood and ACTH concentration increases, and reduces the release of CRH, and the secretion of cytokine such as interleukin (IL-2), IL-8 and tumor necrosis factor increases; The generation of endogenous opiatepeptide is suppressed, and immunity of organisms raises.Before the cattle transportation, suitably give the Niu Zengjia training, also possibly can alleviate transport stress to a certain extent, but workload is big, cost is higher.
In sum, utilize the effect of drug regulation milch cow transport stress apparent in view; And say from the angle of ecologic breeding, preferably select Chinese medicine regulation and control milch cow transport stress for use, can guarantee to control the effect of transport stress, cattle and people's health are not exerted an influence yet.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition of anti-milch cow transport stress, theoretical according to Chinese veterinarian, filter out the herbal mixture compositions that improves the anti-transport stress of milch cow; And on a large amount of experimental basis, confirm the index of the anti-milch cow transport stress of herbal mixture, illustrate the compound Chinese medicinal additive mechanism of action, for the research of anti-stress Chinese medicine provides theoretical foundation.
The technical scheme that the present invention provides is: the pharmaceutical composition of this anti-milch cow transport stress comprises according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 80～100g, Poria 25～30g, Radix Polygalae 15～20g, the Rhizoma Anemarrhenae 15～20g, Fructus Gardeniae 20～30g, Radix Scutellariae 10～20g, Os Draconis 5～10g, Concha Ostreae 10～20g.
The pharmaceutical composition of described anti-milch cow transport stress comprises Semen Ziziphi Spinosae 80g, Poria 25g, Radix Polygalae 20g, Rhizoma Anemarrhenae 15g, Fructus Gardeniae 20g, Radix Scutellariae 10g, Os Draconis 10g, Concha Ostreae 20g according to the metering of crude drug ratio of weight and number.
The pharmaceutical composition of described anti-milch cow transport stress comprises according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 90g, Poria 28g, Radix Polygalae 18g, Rhizoma Anemarrhenae 18g, Fructus Gardeniae 25g, Radix Scutellariae 15g, Os Draconis 8g, Concha Ostreae 15g.
The pharmaceutical composition of described anti-milch cow transport stress comprises according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 100g, Poria 30g, Radix Polygalae 15g, Rhizoma Anemarrhenae 20g, Fructus Gardeniae 30g, Radix Scutellariae 15g, Os Draconis 5g, Concha Ostreae 10g.
The pharmaceutical composition of described anti-milch cow transport stress comprises according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 95g, Poria 25g, Radix Polygalae 20g, Rhizoma Anemarrhenae 15g, Fructus Gardeniae 30g, Radix Scutellariae 10g, Os Draconis 5g, Concha Ostreae 20g.
The preparation of drug combination method of described anti-milch cow transport stress comprises according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 85g, Poria 30g, Radix Polygalae 15g, Rhizoma Anemarrhenae 18g, Fructus Gardeniae 25g, Radix Scutellariae 15g, Os Draconis 10g, Concha Ostreae 15g.
The preparation of drug combination method of described anti-milch cow transport stress comprises, proportionally letter sorting; Pulverize; Weighing; Mix; Quality examination; Packing.
The application of the pharmaceutical composition of described anti-milch cow transport stress: the medicine that is used to prepare anti-milch cow transport stress.
The present invention is through experimentation, effectively stoped the stress state Sanguis Bovis seu Bubali sugar concentration of stimulating the secretion of milk to raise, and suppresses adrenocortical hormone, the lactic dehydrogenase enzyme concentration raises, and avoids heart and liver damage.The present invention is easy to use, and only need convert admix in the feedstuff according to the body weight of milch cow get final product, is expected to develop the anti-stress medicine preparation new product that becomes use before a kind of new milch cow transportation.
Description of drawings
Fig. 1: the present invention influences the milch cow blood sugar level
The I group is not for receiving the normal control group that transport stress stimulates;
The II group is for using the matched group of commercially available herbal mixture immunity additive;
The III group is to receive the matched group that transport stress stimulates does not still have medication;
The IV group is for using the matched group of pharmaceutical composition of the present invention
Fig. 2: the present invention is to the influence of cow serum level of adrenocortical hormone
The I group is not for receiving the normal control group that transport stress stimulates;
The II group is to receive the matched group that transport stress stimulates does not still have medication;
The III group is for using the matched group of commercially available herbal mixture immunity additive;
The IV group is for using the matched group of pharmaceutical composition of the present invention.
Fig. 3: the present invention is to the influence of cow serum lactic acid dehydrogenase
The I group is not for receiving the normal control group that transport stress stimulates;
The II group is for using the matched group (using dosage is the 1.0g/kg body weight) of pharmaceutical composition of the present invention;
The III group is for using the matched group (using dosage is the 2.0g/kg body weight) of pharmaceutical composition of the present invention;
The IV group is for using the matched group of commercially available herbal mixture immunity additive;
V is to receive the matched group that transport stress stimulates does not still have medication.
The specific embodiment
Below in conjunction with the instance of the preparation of pharmaceutical compositions of the anti-milch cow transport stress of the present invention, the specific embodiment of the present invention and purposes are described.
Embodiment 1: comprise Semen Ziziphi Spinosae 80g, Poria 25g, Radix Polygalae 20g, Rhizoma Anemarrhenae 15g, Fructus Gardeniae 20g, Radix Scutellariae 10g, Os Draconis 10g, Concha Ostreae 20g according to the metering of crude drug ratio of weight and number.
Embodiment 2: comprise according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 90g, Poria 28g, Radix Polygalae 18g, Rhizoma Anemarrhenae 18g, Fructus Gardeniae 25g, Radix Scutellariae 15g, Os Draconis 8g, Concha Ostreae 15g.
Embodiment 3: comprise according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 100g, Poria 30g, Radix Polygalae 15g, Rhizoma Anemarrhenae 20g, Fructus Gardeniae 30g, Radix Scutellariae 15g, Os Draconis 5g, Concha Ostreae 10g.
Embodiment 4: comprise according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 95g, Poria 25g, Radix Polygalae 20g, Rhizoma Anemarrhenae 15g, Fructus Gardeniae 30g, Radix Scutellariae 10g, Os Draconis 5g, Concha Ostreae 20g.
Embodiment 5: comprise according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 85g, Poria 30g, Radix Polygalae 15g, Rhizoma Anemarrhenae 18g, Fructus Gardeniae 25g, Radix Scutellariae 15g, Os Draconis 10g, Concha Ostreae 15g.
Method for preparing: proportionally letter sorting; Pulverize; Weighing; Mix; Quality examination; Packing.
Usage and dosage: before the milch cow transportation,, irritate stomach, logotype 3 days according to the 2.0g/kg body weight.
Result of use:
(1) the present invention influences the milch cow blood sugar level
Detect testing result such as Fig. 1 by Great Wall, Baoding clinical reagent company limited blood sugar detection test kit description.After the result was illustrated in and receives transport stress, the blood glucose of matched group III cattle raise rapidly, compare behind the 4h with before the experiment, significant difference (P 0.05); Blood sugar concentration descends behind the 5h, but still is higher than for not receiving the normal control group I that transport stress stimulates; The commercially available herbal mixture immunity additive of the Niu Yingyong of matched group II (Handan City refreshing health pharmaceutcal corporation, Ltd), stimulated by transport stress after, the blood sugar concentration of cattle is higher than normal control group I, being lower than all the time stress the matched group III; And after the matched group IV used pharmaceutical composition of the present invention and stimulated by transport stress, the blood sugar concentration of cattle did not have significant change all the time.
(2) the present invention is to the influence of cow serum level of adrenocortical hormone
Utilize the adrenocortical hormone test kit of the excellent Nikon bio tech ltd in Beijing to detect the serum level of adrenocortical hormone, testing result such as Fig. 2.Although showing the matched group III group of using commercially available herbal mixture immunity additive, the result can make blood glucose, the level of adrenocortical hormone of Ox blood serum be in metastable state; But apparently higher than being the normal control group I that does not receive the transport stress stimulation; And have urinate, defecation frequency is maximum, stress such as irritable uneasiness; And be that the matched group IV of using pharmaceutical composition of the present invention makes blood glucose, the level of adrenocortical hormone of cattle be in metastable state, there is not marked difference with normal control group I.Still there is not the matched group II stress of medication very strong and receive the transport stress stimulation.
(3) the present invention is to the influence to transportation cow serum lactic acid dehydrogenase
The lactic dehydrogenase enzyme reagent kit that utilizes Shanghai to grind living biochemical reagents company limited has detected serum lactate dehydrogenase (SLD) test kit level, testing result such as Fig. 3.
The result shows application pharmaceutical composition matched group II of the present invention, III, makes the lactic acid dehydrogenase level of Ox blood serum be in metastable state, does not have marked difference with normal control group I.
Above-mentioned result of use detects the behavior criterion: have urinate, defecation frequency is maximum, occur disorderly playing, dash rush etc. irritable uneasy, even the transport stress that bites reaction.
Detect the index criterion: use the milch cow of pharmaceutical composition of the present invention with for not receiving the normal control group that transport stress stimulates; Receive transport stress stimulate but do not have a medication stress matched group; And use commercially available herbal mixture immunity additive stress matched group the detection index relatively; Carry out the biometrics analysis, judge the significance of difference.
If the blood testing index does not still have the matched group of medication low than receiving the transport stress stimulation, show it is effective; If the blood testing index stimulates the matched group that does not still have medication low and stress not excited behavior or stress excited behavior low weight than receiving transport stress, show it is produce effects.Obvious effective rate is 97.6%.
Also introduced the herbal mixture immunity additive that commercially available Handan City refreshing health pharmaceutcal corporation, Ltd produces as comparative test the present invention; In the transport stress stimulating course; Feed the cattle of commercially available herbal mixture immunity additive and compared by the transport stress cattle with medication not, medication does not receive the relatively excitement of transport stress cattle.
Listed examples of the present invention is intended to further to illustrate the formulation method and the application direction of the pharmaceutical composition of the anti-milch cow transport stress of the present invention, and scope of the present invention is not constituted any restriction.
Claims (8)
1. the pharmaceutical composition of an anti-milch cow transport stress comprises according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 80～100g, Poria 25～30g, Radix Polygalae 15～20g, the Rhizoma Anemarrhenae 15～20g, Fructus Gardeniae 20～30g, Radix Scutellariae 10～20g, Os Draconis 5～10g, Concha Ostreae 10～20g.
2. according to the pharmaceutical composition of the said anti-milch cow transport stress of claim 1, it is characterized in that: comprise Semen Ziziphi Spinosae 80g, Poria 25g, Radix Polygalae 20g, Rhizoma Anemarrhenae 15g, Fructus Gardeniae 20g, Radix Scutellariae 10g, Os Draconis 10g, Concha Ostreae 20g according to the metering of crude drug ratio of weight and number.
3. according to the pharmaceutical composition of the said anti-milch cow transport stress of claim 1, it is characterized in that: comprise according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 90g, Poria 28g, Radix Polygalae 18g, Rhizoma Anemarrhenae 18g, Fructus Gardeniae 25g, Radix Scutellariae 15g, Os Draconis 8g, Concha Ostreae 15g.
4. according to the pharmaceutical composition of the said anti-milch cow transport stress of claim 1, it is characterized in that: comprise according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 100g, Poria 30g, Radix Polygalae 15g, Rhizoma Anemarrhenae 20g, Fructus Gardeniae 30g, Radix Scutellariae 15g, Os Draconis 5g, Concha Ostreae 10g.
5. according to the pharmaceutical composition of the said anti-milch cow transport stress of claim 1, it is characterized in that: comprise according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 95g, Poria 25g, Radix Polygalae 20g, Rhizoma Anemarrhenae 15g, Fructus Gardeniae 30g, Radix Scutellariae 10g, Os Draconis 5g, Concha Ostreae 20g.
6. according to the preparation of drug combination method of the said anti-milch cow transport stress of claim 1, it is characterized in that: comprise according to the metering of crude drug ratio of weight and number: Semen Ziziphi Spinosae 85g, Poria 30g, Radix Polygalae 15g, Rhizoma Anemarrhenae 18g, Fructus Gardeniae 25g, Radix Scutellariae 15g, Os Draconis 10g, Concha Ostreae 15g.
7. according to the preparation of drug combination method of the said anti-milch cow transport stress of claim 1, it is characterized in that: described pharmaceutical composition proportionally sorts; Pulverize; Weighing; Mix; Quality examination; Packing.
8. according to the application of the pharmaceutical composition of the said anti-milch cow transport stress of claim 1, it is characterized in that: described pharmaceutical composition is used to prepare the medicine of anti-milch cow transport stress.
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| CN103315184A (en) * | 2013-07-11 | 2013-09-25 | 曾勇 | Feed additive for alleviating unfavorable influences of transport stress to growth of piglets |
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