CN102698672A - Microfluidic reactor - Google Patents
Microfluidic reactor Download PDFInfo
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- CN102698672A CN102698672A CN2012101590026A CN201210159002A CN102698672A CN 102698672 A CN102698672 A CN 102698672A CN 2012101590026 A CN2012101590026 A CN 2012101590026A CN 201210159002 A CN201210159002 A CN 201210159002A CN 102698672 A CN102698672 A CN 102698672A
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Abstract
The invention discloses a microfluidic reactor which comprises a base, a reaction pool plate, a slide, a rubber ring and a spiral cover. The base, the reaction pool plate and the slide form a complete reaction chamber; the spiral cover is horizontally pressed on the slide through the buffering of the rubber ring to seal the reaction chamber. Due to the bionic design of a fusiform reaction pool on the reaction pool plate, the flow field is distributed uniformly during the flow of the fluid in the reaction chamber, and no fluid is left during discharge. The microfluidic reactor can not be affected by the placement azimuth and can be also used for the reaction needing temperature controlling and lighting. The microfluidic reactor can be widely used for the microfluidic reaction experiments in various fields including the biological field, the chemical field, the medical field and the like.
Description
Technical field
The invention discloses a kind of micro-fluid reactor, but particularly a kind of Flow Field Distribution is even, the micro-fluid reactor of no raffinate temperature control.Belong to microfluid biochemical reaction instrument preparing technical field.
Background technology
Micro-fluid reactor is as the main place of microfluid biochemical reaction, and its performance quality directly has influence on the result of reaction.In the complete biochemical reaction, generally all need in same reative cell, carry out plurality of reagents and alternately fill the multistep of changing and react suddenly, but the liquid of trace when getting into reative cell because the variation of sectional area causes the change of flow velocity; And when in reative cell, flowing, can receive frictional resistance, add some capillary siphonages; Be easy to cause rate of flow of fluid uneven; Flow Field Distribution is inconsistent, fluid is charged into cause density unevenness behind the reative cell even can't be full of, and raffinate is arranged when from reative cell, discharging; Cause the cross pollution of reagent, influence reaction result.For alleviating the raffinate problem; Generally reaction tank is designed to the orientation placement of vertical or inclination certain angle in the pre-existing reactors; A kind of device of accelerating biological chip micro fluid reaction is disclosed like Chinese invention patent (application number 200510024234.0); Wherein the inlet of used reaction cabin must have certain angle with the outlet line, otherwise air can not promote liquid flow and produce bubble.But in some need be the experiment of reaction tank horizontal positioned, such reaction tank can not meet the demands.Based on this, be necessary to design a kind of azimuthal influence of not placed, Flow Field Distribution was even when fluid flowed in the realization response chamber, did not have the micro-fluid reactor of raffinate during discharge.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art and provide a kind of simple and reasonable, processing and manufacturing easily, not placed azimuthal influence, Flow Field Distribution was even when fluid flowed in the realization response chamber, did not have the micro-fluid reactor of raffinate during discharge.
A kind of micro-fluid reactor of the present invention; Comprise: pedestal, reaction tank plate, slide, rubber ring and spiral cover; Be stacked with reaction tank plate, slide on the said pedestal successively; Said spiral cover spinning is being fitted on the said slide on the said pedestal and through said rubber ring; It is characterized in that: said reaction tank plate middle part is provided with the reaction tank of a similar fusiformis, and the two ends of said reaction tank length direction respectively are provided with an inlet opening, fluid hole, said inlet opening, fluid hole and be located at pedestal on feed pathway or liquid outlet channel corresponding.
In a kind of micro-fluid reactor of the present invention, said reaction tank shape center symmetry, middle wide, two ends are narrow, similar fusiformis; The two ends of said reaction tank and inlet opening or fluid hole profile phase meet at a C, C ', D, D ', form the inlet or the liquid outlet of reaction tank, and the width C C ' of said inlet or liquid outlet or DD ' are: 0.2-6mm; The outline line at reaction tank middle part is straight line AB and straight line A ' B ', and the length of straight line AB or straight line A ' B ' is 2-60mm, and the spacing between straight line AB and the straight line A ' B ' is 2-60mm; Said straight line AB or straight line A ' B ' two ends are passed through circular arc BC, AD or B ' C ', A ' D ' respectively, are connected with end points C, D or C ', the D ' of reaction tank; Among said circular arc BC, AD, B ' C ', the A ' D ', circular arc BC or B ' C ' be some a C, B, 3 of E or some C ', B ', 3 of E ' and with straight line AB or the tangent circular arc of A ' B ', said some E or E ' are that a C or C ' are the symmetric points of axle with BB '; Circular arc AD or A ' D ' be some a D, A, 3 of F or D ', A ', 3 of F ' and with straight line AB or the tangent circular arc of A ' B ', said some F or F ' are that a D or D ' are the symmetric points of axle with AA '.
In a kind of micro-fluid reactor of the present invention, angle ∠ ABC, ∠ A ' B ' C ', ∠ BAD, ∠ B ' A ' D ' that the line between said some A, B, C, D, A ', B ', C ', the D ' constitutes are the 135-165 degree.
In a kind of micro-fluid reactor of the present invention, said reaction tank plate upper and lower surfaces is smooth, smooth; Lower surface has outstanding reference column and the locating hole of being located on the pedestal to match.
In a kind of micro-fluid reactor of the present invention, be located at the inlet opening on the pedestal, inlet and the liquid outlet that fluid hole is communicated in the pedestal side respectively.
In a kind of micro-fluid reactor of the present invention, said pedestal is provided with a draw-in groove, and the draw-in groove middle part is provided with an internal thread, and said reaction tank plate, slide are inlaid in the said draw-in groove, and there is external screw thread said spiral cover outer ring, and spinning is on said internal thread.
In a kind of micro-fluid reactor of the present invention, be provided with the hollow structure that illumination is freely passed through in the middle of the said spiral cover, lower surface is provided with a groove, and said rubber ring is nested in the said groove.
In a kind of micro-fluid reactor of the present invention, said pedestal side is provided with the embedded hole of electrical bar and temperature sensor, and the electrical bar and the temperature sensor that are electrically connected with peripheral hardware control system are inlaid in the said embedded hole.
Operation principle of the present invention is summarized as follows:
Be stacked with reaction tank plate, slide on the said pedestal successively, said spiral cover spinning is on said pedestal, and the three has constituted complete reative cell, and is fitted on the slide reaction tank is airtight through the rubber ring that is inlaid in the spiral cover bottom; Said reaction tank plate middle part is provided with a similar fusiformis, the reaction tank of the no end, uncovered; Because reaction tank in shape, is the smooth circular arc of one section progressive relaxation from the port to the centre, is that one section straight line is compared from the port to the centre with the reaction tank of routine; Relative velocity higher fluid in porch is well spread at y direction; Be full of the entire reaction pond faster, thereby the flow velocity that helps X direction reduces and is tending towards evenly obtaining the flow field that the flow velocity homogeneous distributes very soon; From but solution evenly advances no raffinate reaction tank.The reaction tank of the present invention's preparation, fluid is the flow velocity homogeneous in reative cell, and Flow Field Distribution is even, does not have raffinate when making fluid discharge reative cell.
Because reaction tank plate upper and lower surfaces is all smooth, smooth, can be smooth, tight be placed on the said pedestal makes slide, reaction tank plate, pedestal through the spiral cover of spinning on internal thread in the middle of the draw-in groove, and the three has constituted complete enclosed reaction chamber; The spiral cover upper surface has swing arm, and the turn swing arm can make spiral cover level on draw-in groove move down, and then guarantees that the slide of below pressurized is evenly stressed.Be inlaid in the rubber ring in the said spiral cover lower surface groove, can play cushioning effect.
Reaction tank plate lower surface has outstanding reference column, and said pedestal upper surface has the locating hole that matches with it, can the accurate location of realization response pond plate on pedestal.
Said pedestal upper surface has inlet opening and the fluid hole that is communicated in side inlet and liquid outlet respectively, its liquid hole site and shape size respectively be positioned at pedestal on the two-port of reaction tank corresponding.Pedestal upper surface is smooth, smooth, has constituted the end of reative cell, and it is smooth and easy mobile to be beneficial to fluid.
Said pedestal is provided with draw-in groove, and its spacing and slide are suitable, can play the location and the fixation of slide.
In the middle of the said spiral cover is hollow structure, can required light path freely passed through, and can also see through the indoor situation of slide observing response.
There is the embedded hole of electrical bar or temperature sensor said pedestal side, can embed the electrical bar or the temperature sensor that receive circuit control, through the temperature control of peripheral hardware control system realization response chamber.
Beneficial effect of the present invention is sketched in following:
The present invention has designed a kind of micro-fluid reactor, comprises pedestal, reaction tank plate, slide, rubber ring and spiral cover.Because reaction tank has adopted the bionics design; Port is the smooth circular arc of one section progressive relaxation to the centre; Making the reaction tank global shape is the fusiformis of similar fish, can make relative velocity higher fluid in porch well to the periphery diffusion, so can obtain the flow field that the flow velocity homogeneous distributes very soon thus; The reaction tank of this fusiformis is compared with conventional rhombus reaction tank, has improved homogeneity.Because the even distribution of flow field velocity advances fluid homogeneous in reaction tank, concentration is even, does not have remnants during discharge.So this reactor is not placed azimuthal influence, but level, vertically or by other orientation angles place arbitrarily.
The screw fixation method design of spiral cover receives force level even when making closed.The hollow structure of spiral cover can be implemented in and carry out illumination reaction and can observing reaction process in the reative cell.The adding of function of temperature control also makes this reactor have extensive applicability.It is simple that multiple positioning design makes the reactor monolith assembling simultaneously, can be widely used in the micro fluid reaction experiment in each field such as biology, chemistry, medicine.
Description of drawings
Accompanying drawing 1 is the micro-fluid reactor decomposing schematic representation:
Accompanying drawing 2 is assembling sketch mapes of micro-fluid reactor:
Accompanying drawing 3 is pedestal sketch mapes:
Accompanying drawing 4 is reaction tank plate sketch mapes:
Accompanying drawing 5 is spiral cover sketch mapes:
Accompanying drawing 6 is that the reaction tank shape constitutes sketch map:
Accompanying drawing 7 is reaction tank, hot spot and spiral cover inner edge relative position sketch map:
Accompanying drawing 8 is conventional rhombus reaction tank;
Accompanying drawing 9 is fusiformis reaction tank of the present invention;
Accompanying drawing 10-1 is the contoured velocity cloud charts of conventional rhombus reaction tank;
Accompanying drawing 10-2 is the contoured velocity cloud charts of fusiformis reaction tank of the present invention;
The practical implementation method
Below in conjunction with accompanying drawing and embodiment the present invention is done further explain:
Embodiment 1
Referring to accompanying drawing 1-10; A kind of micro-fluid reactor; Comprise: pedestal 10, reaction tank plate 20, slide 30, rubber ring 40 and spiral cover 50, said reaction tank plate 20 is placed on the pedestal 10, and said slide 30 covers on said reaction tank plate 20; The three has constituted complete reative cell, and is pressed on the slide closed by said spiral cover 50 levels through said rubber ring 40 bufferings.
Said pedestal 10 upper surfaces have dark 2.2mm; The cuboid locating hole 15 of length of side 2mm, reaction tank plate 20 can be implemented in the accurate location on the pedestal 10 through reference column 21 and locating hole 15, and pedestal 10 upper surfaces are smooth smooth; The circular hole that two radius 0.9mm are arranged; One is inlet opening 13, and another is a fluid hole 14, corresponding identical with liquid outlet 23 with the inlet 22 of reaction tank 24 respectively.Inlet opening 13, fluid hole 14 are communicated in the inlet 11 and the liquid outlet 12 of pedestal 10 sides respectively, and inlet 11 is the screwed hole of 10-32 made in U.S.A with liquid outlet 12, can be 1/16 through hand-tight joint and external diameter, and " teflon pipe (1.5875mm) is connected.
Bossed draw-in groove 17 on the pedestal 10, separation 25mm, high 8mm can be with wide 25mm, long 75mm, slide 30 location of thick 1mm, slide 30 pastes and covers on reaction tank plate 20 tops, constitutes complete reative cell with reaction tank plate 20 and pedestal 10.
Reative cell through spiral cover 50 be pressed in carry out on the slide 30 airtight.Said spiral cover 50 high 8mm are with the external screw thread 53 of diameter 34mm outward, and upper surface has two swing arms 51.The internal thread 16 of the diameter 34mm that coincide with spiral cover 50 is arranged on the said pedestal draw-in groove 17, and turn swing arm 51 can make spiral cover 50 levels be pressed on the slide 30 downwards, and slide 30 is stressed even, has guaranteed the intact airtight of reative cell.
Said spiral cover 50 lower surfaces have an annular groove 52, can nested inside radius 12.6mm, and the rubber ring 40 of outer radius 15mm plays cushioning effect.
In the middle of the said spiral cover 50 is the cylinder 54 of hollow, and internal diameter is 20mm, and required light path is freely passed through, and can also see through the indoor situation of slide observing response.As shown in Figure 7, be the hot spot 70 of 14.0288mm * 10.5216mm (4:3) and the relative position sketch map of spiral cover cylinder 54 edges and reaction tank 24.
There are electrical bar embedded hole 19 and temperature sensor embedded hole 110 in said pedestal 10 sides, can embed the electrical bar or the temperature sensor that receive circuit control respectively, through the realization response temperature control of peripheral hardware control system.
Adopt the Fluent cfdrc that the fusiformis reaction tank and the corresponding conventional rhombus reaction tank of parameter of present embodiment are carried out modeling and simulating.For simplified model, the feed liquor and the liquid outlet channel of reaction tank replace with rectangle, the long 1.8mm of said rectangular channel, wide 1.2mm, corresponding with the reaction tank two ends (like Fig. 8, shown in Figure 9).The inlet flow velocity boundary condition of emulation is 5mm/s, the mid-plane that the effect comparison of simulation result selects for use 0.5mm highly to locate, and the VELOCITY DISTRIBUTION isopleth cloud atlas of analyzing this plane is (like Figure 10-1; Shown in Figure 10-2); Reduced parameter is selected evening ratio R, R=A/T. wherein, A represent the area in the interior flow field of speed between 0.47-0.95mm/s of reaction zone; Be even area, T represents the gross area in entire reaction pond.In the rhombus reaction tank, evenly area A is 204.3mm
2, gross area T is 298.1mm
2, evening ratio R=204.3/298.1=68.53%.
In the fusiformis reaction tank, evenly area A is 260.2mm
2, gross area T is 366.1mm
2, evening ratio R=260.2/336.1=77.42%.It is thus clear that the evening ratio of fusiformis reaction tank is bigger, explain that the even effect of fusiformis reaction tank is better than conventional rhombus reaction tank.
Embodiment 2
The structure of embodiment 2 is identical with embodiment 1, and the concrete structure parameter is:
∠ ABC, ∠ A ' B ' C ', ∠ BAD, ∠ B ' A ' D ' are 135 degree.Said straight line AB and the long 2mm of straight line A ' B ', the spacing between straight line AB and the straight line A ' B ' is 2mm.The width C C ' of reaction tank inlet or liquid outlet and DD ' are 0.2mm, the long 0.3mm of rectangular channel.Reaction tank gross area T is about 7mm
2Carry out the Fluent analog simulation with entrance velocity 5mm/s, the even area A of the even speed that obtains between 0.46-0.92mm/s is 5.4mm
2, evening ratio R (A/T) is 77.14%; Contrast corresponding conventional rhombus pond, reaction tank gross area T is 6.1mm
2, evenly area A is 4mm
2, evening ratio R is 65.57%.In this embodiment, the evening ratio of fusiformis reaction tank is bigger, explains that the even effect in fusiformis pond is better than conventional rhombus reaction tank.
Embodiment 3
The structure of embodiment 3 is identical with embodiment 1, and the concrete structure parameter is:
∠ ABC, ∠ A ' B ' C ', ∠ BAD, ∠ B ' A ' D ' are 165 degree.Said straight line AB and the long 60mm of straight line A ' B ', the spacing between straight line AB and the straight line A ' B ' is 50mm, the width C C ' of reaction tank inlet or liquid outlet and DD ' they are 6mm, the long 9mm of rectangular channel.Reaction tank gross area T is about 8979mm
2Carry out the Fluent analog simulation with entrance velocity 50mm/s, obtaining the even area A of even speed between 7.2-10.9mm/s is 6079mm
2, evening ratio R (A/T) is 67.70%; Contrast corresponding conventional rhombus pond, reaction tank gross area T is 7706mm
2, evenly area A is 4210mm
2, evening ratio R is 54.63%.In this embodiment, the evening ratio of fusiformis reaction tank is bigger, explains that the even effect in fusiformis pond is better than conventional rhombus reaction tank.
Embodiment 4
The structure of embodiment 4 is identical with embodiment 1, and the concrete structure parameter is:
The high 1mm of reaction tank, said straight line AB and the long 16mm of straight line A ' B ', the spacing between straight line AB and the straight line A ' B ' is 12mm, the width C C ' of reaction tank inlet or liquid outlet and DD ' they are 2mm, the long 3mm of rectangular channel.The inlet flow velocity boundary condition of emulation is 5mm/s,
Adopt the Fluent cfdrc that the fusiformis reaction tank and the corresponding conventional rhombus reaction tank of parameter of present embodiment are carried out modeling and simulating, emulation subtended angle ∠ ABC is respectively 125 degree, three group models when 135 degree, 145 are spent.In order to obtain the optimal solution of fusiformis reaction tank shape, subtended angle ∠ ABC to 148 degree and 152 degree that continue increase fusiformis pond carry out modeling and simulating simultaneously.The mid-plane that the effect comparison of simulation result selects for use 0.5mm highly to locate; Analyze the VELOCITY DISTRIBUTION isopleth cloud atlas on this plane; Reduced parameter is selected evening ratio R, R=A/T. wherein, A represent the area in the interior flow field of speed between 0.9-1.4mm/s of reaction zone; Be even area, T represents the gross area in entire reaction pond.
Simulation calculation result sees table 1; Can draw from table 1: three groups of contrast simulations; The R value of fusiformis reaction tank is greater than the R value of corresponding rhombus reaction tank; The even effect that fusiformis reaction tank of the present invention is described is superior to conventional rhombus reaction tank: the subtended angle ∠ ABC in fusiformis pond spends when 152 spend from 125, and the R value increases afterwards earlier and reduces, maximum when 145 spend.Further increase subtended angle, evenly the value of area increases near saturated, but the increase of the gross area reduces the R value, has also wasted reaction reagent, and in the present embodiment, 145 degree are optimal solution.
Table 1 is the data statistics that obtains after conventional rhombus reaction tank and the fusiformis reaction tank fluent of the present invention emulation.
Table 1
The above embodiment has only expressed embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction of claim of the present invention.Should be pointed out that for the person of ordinary skill of the art under the prerequisite that does not break away from the present invention's design, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with accompanying claims.
Claims (8)
1. micro-fluid reactor; Comprise: pedestal, reaction tank plate, slide, rubber ring and spiral cover; Be stacked with reaction tank plate, slide on the said pedestal successively; Said spiral cover spinning is being fitted on the said slide on the said pedestal and through said rubber ring; It is characterized in that: said reaction tank plate middle part is provided with the reaction tank of a similar fusiformis, and the two ends of said reaction tank length direction respectively are provided with an inlet opening, fluid hole, said inlet opening, fluid hole and be located at pedestal on feed pathway or liquid outlet channel corresponding.
2. a kind of micro-fluid reactor according to claim 1 is characterized in that: said reaction tank shape center symmetry, and middle wide, two ends are narrow, similar fusiformis; The two ends of said reaction tank and inlet opening, fluid hole profile phase meet at a C, C ', D, D ', form the inlet or the liquid outlet of reaction tank, and the width C C ' of said inlet or liquid outlet or DD ' are: 0.2-6mm; The outline line at reaction tank middle part is straight line AB and straight line A ' B ', and the length of straight line AB or straight line A ' B ' is 2-60mm, and the spacing between straight line AB and the straight line A ' B ' is 2-60mm; Said straight line AB or straight line A ' B ' two ends are passed through circular arc BC, AD or B ' C ', A ' D ' respectively, are connected with end points C, D or C ', the D ' of reaction tank; Among said circular arc BC, AD, B ' C ', the A ' D ', circular arc BC or B ' C ' be some a C, B, 3 of E or some C ', B ', 3 of E ' and with straight line AB or the tangent circular arc of A ' B ', said some E or E ' are that a C or C ' are the symmetric points of axle with BB '; Circular arc AD or A ' D ' be some a D, A, 3 of F or D ', A ', 3 of F ' and with straight line AB or the tangent circular arc of A ' B ', said some F or F ' are that a D or D ' are the symmetric points of axle with AA '.
3. said a kind of micro-fluid reactor according to claim 2 is characterized in that: angle ∠ ABC, ∠ A ' B ' C ', ∠ BAD, ∠ B ' A ' D ' that the line between said some A, B, C, D, A ', B ', C ', the D ' constitutes are the 135-165 degree.
4. a kind of micro-fluid reactor according to claim 3 is characterized in that: said reaction tank plate upper and lower surfaces is smooth, smooth; Lower surface has outstanding reference column and the locating hole of being located on the pedestal to match.
5. a kind of micro-fluid reactor according to claim 4 is characterized in that: be located at the inlet opening on the pedestal, inlet and the liquid outlet that fluid hole is communicated in the pedestal side respectively.
6. a kind of micro-fluid reactor according to claim 5; It is characterized in that: said pedestal is provided with a draw-in groove, and the draw-in groove middle part is provided with an internal thread, and said reaction tank plate, slide are inlaid in the said draw-in groove; There is external screw thread said spiral cover outer ring, and spinning is on said internal thread.
7. a kind of micro-fluid reactor according to claim 6 is characterized in that: be provided with the hollow structure that illumination is freely passed through in the middle of the said spiral cover, lower surface is provided with a groove, and said rubber ring is nested in the said groove.
8. a kind of micro-fluid reactor according to claim 7 is characterized in that: said pedestal side is provided with the embedded hole of electrical bar or temperature sensor, and the electrical bar or the temperature sensor that are electrically connected with peripheral hardware control system are inlaid in the said embedded hole.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103217326A (en) * | 2013-03-28 | 2013-07-24 | 广州安必平医药科技有限公司 | Sample reaction cabin and detection reagent adding method |
| CN104888678A (en) * | 2015-06-16 | 2015-09-09 | 上海和伍复合材料有限公司 | Microreactor adopting conical non-laminated structure |
| CN105308452A (en) * | 2013-01-03 | 2016-02-03 | 布里格姆女子医院有限公司 | System and method for a biomimetic fluid processing |
| CN105536669A (en) * | 2016-01-21 | 2016-05-04 | 华东理工大学 | Detachable micro-channel reactor |
| CN108286076A (en) * | 2018-04-17 | 2018-07-17 | 中南大学 | System and its application process is prepared in situ in a kind of biochip |
| US11566214B2 (en) | 2014-03-31 | 2023-01-31 | Brigham And Women's Hospital, Inc. | Systems and methods for biomimetic fluid processing |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1683560A (en) * | 2005-03-07 | 2005-10-19 | 上海百傲科技有限公司 | Device and method for accelerating biological chip micro fluid reaction |
| CN1730142A (en) * | 2004-08-06 | 2006-02-08 | 日立产业有限公司 | Micro fluid chip |
| WO2008053641A1 (en) * | 2006-11-01 | 2008-05-08 | Konica Minolta Medical & Graphic, Inc. | Microchip and microchip inspection system |
| WO2010016800A1 (en) * | 2008-08-08 | 2010-02-11 | Agency For Science, Technology And Research | Microfluidic continuous flow device |
| CN102240535A (en) * | 2011-08-01 | 2011-11-16 | 利穗科技(苏州)有限公司 | Caterpillar type microreactor |
-
2012
- 2012-05-21 CN CN201210159002.6A patent/CN102698672B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1730142A (en) * | 2004-08-06 | 2006-02-08 | 日立产业有限公司 | Micro fluid chip |
| CN1683560A (en) * | 2005-03-07 | 2005-10-19 | 上海百傲科技有限公司 | Device and method for accelerating biological chip micro fluid reaction |
| WO2008053641A1 (en) * | 2006-11-01 | 2008-05-08 | Konica Minolta Medical & Graphic, Inc. | Microchip and microchip inspection system |
| WO2010016800A1 (en) * | 2008-08-08 | 2010-02-11 | Agency For Science, Technology And Research | Microfluidic continuous flow device |
| CN102240535A (en) * | 2011-08-01 | 2011-11-16 | 利穗科技(苏州)有限公司 | Caterpillar type microreactor |
Non-Patent Citations (2)
| Title |
|---|
| J.J.CHEN ET AL.: "Analysis of filling of an oval disk-shaped chamber with microfluidic flows", 《SENSORS AND ACTUATORS A：PHYSICAL》 * |
| J.J.CHEN ET AL.: "Analysis of filling of an oval disk-shaped chamber with microfluidic flows", 《SENSORS AND ACTUATORS A：PHYSICAL》, vol. 132, no. 2, 17 April 2006 (2006-04-17) * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105308452A (en) * | 2013-01-03 | 2016-02-03 | 布里格姆女子医院有限公司 | System and method for a biomimetic fluid processing |
| US9795965B2 (en) | 2013-01-03 | 2017-10-24 | Brigham And Women's Hospital, Inc. | System and method for a biomimetic fluid processing |
| CN105308452B (en) * | 2013-01-03 | 2018-02-06 | 布里格姆女子医院有限公司 | The system and method for bionical fluid processing |
| US10343163B2 (en) | 2013-01-03 | 2019-07-09 | The Brigham And Women's Hospital, Inc. | System and method for a biomimetic fluid processing |
| US10710073B2 (en) | 2013-01-03 | 2020-07-14 | Brigham And Women's Hospital, Inc. | System and method for biomimetic fluid processing |
| US11396016B2 (en) | 2013-01-03 | 2022-07-26 | The Brigham And Women's Hospital, Inc. | System and method for a biomimetic fluid processing |
| CN103217326A (en) * | 2013-03-28 | 2013-07-24 | 广州安必平医药科技有限公司 | Sample reaction cabin and detection reagent adding method |
| US11566214B2 (en) | 2014-03-31 | 2023-01-31 | Brigham And Women's Hospital, Inc. | Systems and methods for biomimetic fluid processing |
| CN104888678A (en) * | 2015-06-16 | 2015-09-09 | 上海和伍复合材料有限公司 | Microreactor adopting conical non-laminated structure |
| CN105536669A (en) * | 2016-01-21 | 2016-05-04 | 华东理工大学 | Detachable micro-channel reactor |
| CN108286076A (en) * | 2018-04-17 | 2018-07-17 | 中南大学 | System and its application process is prepared in situ in a kind of biochip |
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| CN102698672B (en) | 2014-01-29 |
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