CN102692910B - Online controller for controlling circulating, insulating, cleaning and plasma melting of raw blood plasma bags - Google Patents
Online controller for controlling circulating, insulating, cleaning and plasma melting of raw blood plasma bags Download PDFInfo
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- CN102692910B CN102692910B CN201210187426.3A CN201210187426A CN102692910B CN 102692910 B CN102692910 B CN 102692910B CN 201210187426 A CN201210187426 A CN 201210187426A CN 102692910 B CN102692910 B CN 102692910B
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Abstract
The invention discloses an online controller for controlling circulating, insulating, cleaning and plasma melting of raw blood plasma bags. The online controller mainly comprises a working platform, a circulating, insulating and soaking tank, an equipment box body, a circulating water washing station, a first compressed air washing station, a conveyer belt, an alcohol tank, a conveyer belt, a fresh water washing station, a second compressed air washing station, a main transmission motor, a circulating water and alkali liquor circulating system, an alcohol circulating system and an electrical appliance control system. According to the invention, by virtue of the accurate online control on plasma melting temperatures, biological activities of various biological proteins in blood plasma are protected, and the loss of the plasma proteins in an upstream process is effectively reduced; a series of continuous cleaning operations of automatic cleaning, disinfection and leaky bag eliminating and the like on the blood plasma bags in a plasma melting process are implemented by virtue of online computer automation control, thus avoiding cross contamination caused by open-type operation in the plasma melting process; in addition, the water circulating and alcohol filtering devices are designed and mounted, thus greatly reducing the consumption of alcohol and water for injection and achieving remarkable benefits of energy conservation and consumption reduction.
Description
Technical field
The present invention relates to a kind of raw blood plasma bag is cleaned, sterilized and melts the equipment set of slurry, be specifically related to the clean slurry On-line Control device that melts of a kind of raw blood plasma bag circulation insulation.
Background technology
The existing raw blood plasma bag of domestic blood product industry treatment facility can not realization flowization operate, generally in fermentation vat, put into water for injection and carry out plasma bags cleaning operation, in alcohol pool, configure suitable concentration alcohol and carry out plasma bags sterilizing operation, after then plasma bags flushing being dried, deliver to next step operation.Whole plasma bags cleaning and sterilizing process is by manually completing, and what technological design adopted substantially is open, interrupted, manual mode of operation, have the risk of human error, pollution and cross pollution, and labour intensity is large, and operating process is consuming time many.
< < GMP (revised edition in 2010) > > October in 2010 ministerial affairs meeting of the 19 Nikkei Ministry of Public Health approve, on March 1st, 2011, go into effect.New edition GMP has proposed clearer and more definite requirement to blood product equipment, " confirming and checking " proposed first, the facility, equipment and the testing instruments that are enterprise should be confirmed, should adopt through production technology, working specification and the method for inspection of checking produce, operation and checkout, and keep lasting proofing state.Yet the plasma bags cleaning operation step in domestic blood product workshop is substantially by manually completing, process is open, interrupted, manual operation, for the checking of system, brings very large difficulty.
Summary of the invention
Based on above-mentioned technical matters, the invention provides the clean slurry On-line Control device that melts of a kind of raw blood plasma bag circulation insulation.
Its technical solution is:
The clean slurry On-line Control device that melts of raw blood plasma bag circulation insulation, it comprises workbench, fermentation vat and conveying belt, is respectively arranged with water rinses station, compressed air rinsing station and/or alcohol pool in the correspondent section of conveying belt.
The leading portion level of said conveyer belt, interlude depression, back segment is tilted to, before and after conveying belt leading portion, set gradually circulating water flushing station and compressed air rinsing the first station, conveying belt interlude is placed in alcohol pool, sets gradually fresh water and rinse station and compressed air rinsing the second station before and after conveying belt back segment.
Further, the cross bar of an extruding plasma bags is set above conveying belt leading portion, cross bar moves up and down, and its hunting frequency and tape transport frequency match.
Further, at conveying belt leading portion, be also provided with the Weighing module that plasma bags is weighed and the pusher that spillage plasma bags is screened out.
On above-mentioned fermentation vat, be also provided with pond body in the water for cleaning circulation heat preservation sandwich layer that carries out heat exchange, circulation heat preservation sandwich layer is communicated with feed tube and drain pipe, feed tube is communicated with respectively refrigerant pipe and heating agent pipeline, in pond body and/or circulation heat preservation sandwich layer, be provided with temperature sensor, temperature sensor connects intelligent temperature control system, and intelligent temperature control system is controlled the switching of valve on refrigerant pipe and heating agent pipeline.
Above-mentioned circulating water flushing station comprises circulating water pipeline, below circulating water pipeline water delivering orifice, be provided with for the transmission of support belt and the casing of collection recirculated water, bottom at casing sets out the mouth of a river, below water delivering orifice, place a staving, the recirculated water of collecting in staving enters circulating water pipeline after by water pump, filtrator.
Above-mentioned alcohol pool connects the alcohol circulation system, the alcohol circulation system comprises alcohol basin, and alcohol basin connects input duct and reflux line, and input duct connects the inlet of alcohol pool, reflux line connects the overflow vent of alcohol pool, and ethanol pump and filtrator are installed in input duct.
Further, this device also comprises alkali liquor circulating system, alkali liquor circulating system and circulating water flushing station common recycle waterpipe and the staving that it is coated with to alkali protection.
Said conveyer belt is formed and is driven by motor by 9 pairs of sprocket wheels; Above-mentioned casing is welded by 304 stainless steels.
Further, this device carries out automatic online control by computing machine.
Useful technique effect of the present invention is:
(1) the present invention has been realized and has been melted the automatic cleaning, sterilization of slurry process plasma bags and spillage bag and detect and a series of continuous clean operations such as screen out by computer automation On-line Control, avoid melting human error, pollution and the cross pollution that in slurry process, open-sky technique causes, significantly reduce labor intensity of operating staff and man hour of labour;
(2) the present invention can carry out airtight, continuous, the process system operation of robotization, reduced the operation easier of technique, and improved the reliability of system verification, meet the requirement of < < GMP (revised edition in 2010) > >;
(3) the present invention by fermentation vat, melt slurry process temperature accurate On-line Control, protected the biologic activity of different kind organism albumen (human immunoglobulin(HIg), antithrombin Ⅲ and platelet cofactor Ⅰ, II, VII, IX, X etc.) in blood plasma, effectively reduce the loss of plasma proteins in process upstream, improve all kinds of active biological protein yields in blood product;
(4) design and installation recirculated water of the present invention, alkali liquor circulating system and the alcohol circulation system, and the mode that adopts plasma bags to carry out disinfection through alcohol pool with conveyor belt flow, saved the consumption of water for injection and alcohol greatly, and effect of energy is remarkable; Wherein obvious with alcohol saving, according to throwing 350 tons of calculating of slurry company's year, can save 93 tons of alcohol, cost-saving nearly 700,000 yuan;
(5) through experimental verification, use this device to process plasma bags after company's cryoprecipitate (blood product intermediate product) pollution rate obviously decline, cryoprecipitate qualification rate is promoted to 96.7% by 91.5%, is equivalent to year save 18.2 tons of blood plasma.
Accompanying drawing explanation
Below in conjunction with accompanying drawing and embodiment, the invention will be further described:
Fig. 1 is the clean structural representation that melts slurry On-line Control device of raw blood plasma bag circulation insulation;
Fig. 2 is the side view of Fig. 1;
Fig. 3 is the structural principle schematic diagram of fermentation vat;
Fig. 4 is the side view of Fig. 3;
Fig. 5 is the structural representation of equipment box;
Fig. 6 is the structural representation of conveying belt;
Fig. 7 is that spillage plasma bags Automatic sieve is except the structural principle schematic diagram of system;
Fig. 8 is recirculated water and alkali lye spraying pipeline schematic diagram;
Fig. 9 is the structural representation of the alcohol circulation system.
In figure: 1-workbench, 2-fermentation vat, 3-conveying belt, 4-circulating water flushing station, 5-compressed air rinsing the first station, 6-alcohol pool, 7-fresh water rinses station, 8-compressed air rinsing the second station, 9-casing, 10-staving, 11-cross bar, 12-support, 13-Weighing module, 14-pusher, 201-water inlet, 202-overflow vent, the movable wheel of 203-, 204-circulation heat preservation sandwich layer, 205-feed tube, 206-drain pipe, 207-refrigerant pipe, 208-heating agent pipeline, 209-temperature sensor, 2010-intelligent temperature control system, 2011-valve, 301-conveying belt leading portion, 302-conveying belt interlude, 303-conveying belt back segment, 401-circulating water pipeline, 402-water pump, 403-filtrator, 404-rotating wash bowl house steward, 405-removes fermentation vat pipeline, 601-alcohol basin, 602-input duct, 603-reflux line, 604-ethanol pump, 605-filtrator, 901-water delivering orifice.
Embodiment
As shown in Figure 1, the clean slurry On-line Control device that melts of raw blood plasma bag circulation insulation, it comprises that workbench 1, fermentation vat 2, conveying belt 3, circulating water flushing station 4, compressed air rinsing the first station 5, alcohol pool 6, fresh water rinse station 7 and compressed air rinsing the second station 8.
Conveying belt 3 is formed and is driven by motor by 9 pairs of sprocket wheels, encompasses Fig. 6 shape.Leading portion 301 levels of conveying belt 3, interlude 302 depressions, back segment 303 is tilted to, before and after conveying belt leading portion 301 places, set gradually circulating water flushing station 4 and compressed air rinsing the first station 5, conveying belt interlude 302 is placed in alcohol pool 6, sets gradually fresh water and rinse station 7 and compressed air rinsing the second station 8 before and after conveying belt back segment 303 places.Plasma bags after fermentation vat 2 thawings, decontamination is taken out and is placed on conveying belt 3, plasma bags is in the course of conveying of conveying belt 3, first through circulating water flushing station 4, rinse for the first time, and compressed air scour the first station 5 dries up, to prevent that moisture residual in plasma bags from entering the concentration that reduces alcohol in alcohol pool in alcohol pool 6; Then plasma bags is passed through alcohol pools with conveying belt 3, and carries out disinfection in alcohol pool; Plasma bags after sterilization moves up with conveying belt, then through fresh water, rinses station 7 and clean for the second time, and compressed air scour the second station 8 dries up, and gets final product output.
Circulating water flushing station 4 comprises circulating water pipeline 401, below circulating water pipeline 401 water delivering orifices, is provided with casing 9, and after recirculated water and fresh water rinse plasma bags, current-sharing enters in casing 9 to collect, and casing 9 also can be used for the transmission of support belt.Casing 9 is welded by 304 stainless steels, affects the quality that plasma bags is cleaned to prevent from getting rusty.In the bottom of casing 9, set out the mouth of a river 901, below water delivering orifice 901, place a staving 10, the recirculated water of collecting in staving 10 enters circulating water pipeline 401 after by water pump 402, filtrator 403 again, and under the pressure of water pump 402 strong flushing plasma bags surface.Recirculated water in staving 10 also can be delivered in fermentation vat 2 and rotating wash bowl house steward 404, as shown in Figure 7.Alcohol pool 6 connects the alcohol circulation system, as shown in Figure 9, the alcohol circulation system comprises alcohol basin 601, alcohol basin 601 connects input duct 602 and reflux line 603, input duct 602 connects the inlet of alcohol pool, reflux line 603 connects the overflow vent of alcohol pool, and ethanol pump 604 and filtrator 605 are installed in input duct.Alcohol in alcohol basin 601 enters in alcohol pool 6 by ethanol pump 604, filtrator 605, plasma bags is sterilized by alcohol pool under the conveying of conveying belt, alcohol overflows in alcohol basin 601 through reflux line 603 in the conveying of ethanol pump, recycles.In production and application process, can sample by sample tap, carry out the detection of alcohol concentration, to control the alcohol concentration for plasma bags sterilization.
After work completes; need be coated with alkali protection to equipment; spraying alkali lye adopts alkali liquor circulating system; alkali liquor circulating system and circulating water flushing station common recycle waterpipe and staving etc.; while needing equipment to be coated with alkali protection, only need change the recirculated water in staving into alkali lye and circulate, can open in addition alkaline stream to rotating wash bowl house steward 404 path; wherein rotating wash bowl house steward 404 connects 3 rotating wash bowls, makes alkali lye to equipment, be coated with alkali operation with the form of spray.By aforesaid operations, can be realized and be coated with alkali operation comprehensively without dead angle, sterilization effect is solid.
Said apparatus also comprises electrical apparatus control system, conveying belt, circulating water flushing station, compressed air rinsing the first station, the alcohol pool circulation system, fresh water rinses station and compressed air rinsing the second station etc. and is all connected with electrical apparatus control system, electrical apparatus control system is controlled the running of the motor rotating for driving conveying belt, and controlled circulation water rinses station, compressed air rinsing the first station, fresh water rinses the unlatching of valve on station and compressed air rinsing the second station, close and the running of water pump, control the unlatching of valve in the alcohol circulation system simultaneously, close and the running of ethanol pump.Electrical apparatus control system connects computing machine, and carries out automatic online control by computing machine.
Certainly, also can set up a plurality of circulating water flushing stations, fresh water and rinse station and compressed air rinsing station, like this can according to the quantity of plasma bags that conveying belt is carried or other situation select appropriate section or whole circulating water flushing station, fresh water flushing station and compressed air rinsing station unlatching, close.
Said apparatus is as follows to the treatment step of raw blood plasma bag: first raw blood plasma bag is taken out from freezer to (30 ℃), serve workbench, then pour in fermentation vat and clean plasma bags surface, the temperature of controlling liquid in fermentation vat is 10-25 ℃; Again the plasma bags after thawing, clean surface is taken out from fermentation vat, be positioned on conveying belt, plasma bags is in the course of conveying of conveying belt, first successively through circulating water flushing station rinse for the first time, compressed air rinsing station dries up for the first time, then enter in alcohol pool and carry out disinfection, through fresh water, rinse successively again that station rinses for the second time, compressed air rinsing station dries up for the second time, finally can output enter next step operation.
Further, the plasma bags being positioned on conveying belt is carrying out before rinsing step, also needing to carry out the automatic detecting step of plasma bags spillage and the step that plasma bags is weighed and spillage plasma bags Automatic sieve is removed for the first time.
It should be noted that, under the instruction of this instructions, any equivalents that those skilled in the art have done, or obvious variant, all should be within protection scope of the present invention.
Claims (9)
1. the clean slurry On-line Control device that melts of raw blood plasma bag circulation insulation, is characterised in that: it comprises workbench, fermentation vat and conveying belt, is respectively arranged with water rinses station, compressed air rinsing station and/or alcohol pool in the correspondent section of conveying belt; The leading portion level of conveying belt, interlude depression, back segment is tilted to, before and after conveying belt leading portion, set gradually circulating water flushing station and compressed air rinsing the first station, conveying belt interlude is placed in alcohol pool, sets gradually fresh water and rinse station and compressed air rinsing the second station before and after conveying belt back segment.
2. clean the melting of a kind of raw blood plasma bag circulation insulation according to claim 1 starched On-line Control device, it is characterized in that: the cross bar that an extruding plasma bags is set above conveying belt leading portion, cross bar moves up and down, and its hunting frequency and tape transport frequency match.
3. the clean slurry On-line Control device that melts of a kind of raw blood plasma bag circulation insulation according to claim 1, is characterized in that: at conveying belt leading portion, be also provided with the Weighing module that plasma bags is weighed and the pusher that spillage plasma bags is screened out.
4. clean the melting of a kind of raw blood plasma bag circulation insulation according to claim 1 starched On-line Control device, it is characterized in that: on fermentation vat, be also provided with pond body in the water for cleaning circulation heat preservation sandwich layer that carries out heat exchange, circulation heat preservation sandwich layer is communicated with feed tube and drain pipe, feed tube is communicated with respectively refrigerant pipe and heating agent pipeline, in pond body and/or circulation heat preservation sandwich layer, be provided with temperature sensor, temperature sensor connects intelligent temperature control system, and intelligent temperature control system is controlled the switching of valve on refrigerant pipe and heating agent pipeline.
5. clean the melting of a kind of raw blood plasma bag circulation insulation according to claim 1 starched On-line Control device, it is characterized in that: described circulating water flushing station comprises circulating water pipeline, below circulating water pipeline water delivering orifice, be provided with for the transmission of support belt and the casing of collection recirculated water, bottom at casing sets out the mouth of a river, below water delivering orifice, place a staving, the recirculated water of collecting in staving enters circulating water pipeline after by water pump, filtrator.
6. clean the melting of a kind of raw blood plasma bag circulation insulation according to claim 1 starched On-line Control device, it is characterized in that: alcohol pool connects the alcohol circulation system, the alcohol circulation system comprises alcohol basin, alcohol basin connects input duct and reflux line, input duct connects the inlet of alcohol pool, reflux line connects the overflow vent of alcohol pool, and ethanol pump and filtrator are installed in input duct.
7. clean the melting of a kind of raw blood plasma bag circulation insulation according to claim 5 starched On-line Control device; it is characterized in that: this device also comprises alkali liquor circulating system, alkali liquor circulating system and circulating water flushing station common recycle waterpipe and the staving that it is coated with to alkali protection.
8. the clean slurry On-line Control device that melts of a kind of raw blood plasma bag circulation insulation according to claim 5, is characterized in that: described conveying belt is formed and driven by motor by 9 pairs of sprocket wheels; Described casing is welded by 304 stainless steels.
9. according to the clean slurry On-line Control device that melts of a kind of raw blood plasma bag circulation insulation described in any one claim in claim 1～8, it is characterized in that: this device carries out automatic online control by computing machine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210187426.3A CN102692910B (en) | 2012-06-08 | 2012-06-08 | Online controller for controlling circulating, insulating, cleaning and plasma melting of raw blood plasma bags |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210187426.3A CN102692910B (en) | 2012-06-08 | 2012-06-08 | Online controller for controlling circulating, insulating, cleaning and plasma melting of raw blood plasma bags |
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| CN102692910A CN102692910A (en) | 2012-09-26 |
| CN102692910B true CN102692910B (en) | 2014-04-09 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071655A (en) * | 2013-01-16 | 2013-05-01 | 衡阳鑫山机械设备制造有限公司 | Combined equipment for automatically cleaning, disinfecting and breaking blood plasma bag |
| CN103056138A (en) * | 2013-01-17 | 2013-04-24 | 衡阳鑫山机械设备制造有限公司 | Washing and sterilizing machine of automatic blood plasma bag washing, sterilizing and breaking equipment |
| CN111871912B (en) * | 2020-06-30 | 2022-03-25 | 山东泰邦生物制品有限公司 | Automatic plasma bag cleaning and breaking system and cleaning method |
| CN113731986B (en) * | 2021-08-31 | 2023-08-29 | 宜兴市昌华过滤器材有限公司 | Multifunctional plasma bag automatic cleaning equipment |
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| WO1998038961A1 (en) * | 1997-03-03 | 1998-09-11 | Cme Telemetrix Inc. | Method and apparatus for screening plasma for interferents in plasma from donor blood bags |
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| CN201807570U (en) * | 2010-10-13 | 2011-04-27 | 湖南东港锑品有限公司 | Antimony powder bag cleaning device |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5344561A (en) * | 1989-05-09 | 1994-09-06 | Pall Corporation | Device for depletion of the leucocyte content of blood and blood components |
| WO1998038961A1 (en) * | 1997-03-03 | 1998-09-11 | Cme Telemetrix Inc. | Method and apparatus for screening plasma for interferents in plasma from donor blood bags |
| CN201565431U (en) * | 2009-04-23 | 2010-09-01 | 上海旺欣豆制品设备有限公司 | Plastic bag cleaning machine |
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Address after: 271000 5666 Longquan Road, hi tech Zone, Tai'an, Shandong Patentee after: SHANDONG TAIBANG BIOLOGICAL PRODUCTS Co.,Ltd. Patentee after: SHANDONG INSTITUTE OF BIOLOGICAL PRODUCTS Address before: 271000 No. 14 East Tiger Hill Road, Shandong, Tai'an Patentee before: SHANDONG TAIBANG BIOLOGICAL PRODUCTS Co.,Ltd. Patentee before: SHANDONG INSTITUTE OF BIOLOGICAL PRODUCTS |
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