CN102690212A - Preparation method of iodixanol - Google Patents
Preparation method of iodixanol Download PDFInfo
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- CN102690212A CN102690212A CN2012101916586A CN201210191658A CN102690212A CN 102690212 A CN102690212 A CN 102690212A CN 2012101916586 A CN2012101916586 A CN 2012101916586A CN 201210191658 A CN201210191658 A CN 201210191658A CN 102690212 A CN102690212 A CN 102690212A
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Abstract
The invention provides a preparation method of iodixanol, which comprises the following steps of: taking a compound of 5-amino-2, 4, 6-triiodo-N, N'-bi (2, 3-dyhydroxy propyl group)-1, 3-phthalamide shown as a structural formula I as a starting material, and preparing an intermediate of 'iodixanol-1' shown as a structural formula II; (2) preparing an intermediate of 'iodixanol-2' shown as a structural formula III through reacting the intermediate of 'iodixanol-1' prepared by the step (1) with NaOH; and (3) preparing iodixanol-2 shown as a structural formula V through reacting the intermediate of 'iodixanol-2' prepared by the step (2) with alkali, a substance M and dimerization reaction reagent in solvent. The method has the following technical effects that (1) the conversion rate in acylation reaction is high, the purity of a product is obviously improved compared with that of the product prepared by other processes; (2) the yield of bi-polymerized iodixanol of the compound A is high, and the liquid phase yield of the product in reaction can reach 92 percent; and (3) the technological operation is simple and high-efficient.
Description
Technical field
The present invention relates to a kind of preparation method of Visipaque 320, belong to the medical chemistry technical field.
Background technology
Visipaque 320 (Iodixanol), chemical name are 5, the two (N of 5'-((2-hydroxyl-1,3-propane) two (ethylenemines)); N'-two (2, the 3-dihydroxypropyl)-2,4,6-three iodo-1; The 3-benzenedicarboxamide by the research and development of Norway Nycomed company, is a kind of novel non-ionic x-ray contrast agent (osmotic pressure is 290mosmol/kg); Nineteen ninety-five takes the lead in going on the market in Germany at blood vessel planted agent time spent and the isoosmotic contrast medium of blood plasma to be unique one, gets into China market and sells in 2002.
Many in recent years researchs show that Visipaque 320 can reduce the incidence of contrast medium complication effectively than other contrast medium, are a kind of safer effective contrast medium.Visipaque 320 gets into blood through direct injection and brings into play drug effect, and dosage is big, and therefore the quality to the Visipaque 320 bulk drug has very high requirement.And then with separation purifying technique very high requirement is arranged to its whole Visipaque 320 is synthetic.
At present relevant Visipaque 320 synthesis technique exists operation more loaded down with trivial details, and it is not high to aggregate into the Visipaque 320 yield by two of compd A, and the cost for purification of final Visipaque 320 is high, and the production cycle is long.
Summary of the invention
The objective of the invention is to overcome the weak point of prior art, a kind of preparation method of Visipaque 320 of process improvement is provided.
The preparation method of Visipaque 320 of the present invention comprises following reactions step:
1) with structural formula compound shown by formula I 5-amino-2,4,6-three iodo-N, N'-two (2, the 3-dihydroxypropyl)-1, the 3-benzenedicarboxamide is a starting raw material, and the preparation structural formula is suc as formula the midbody shown in the II " Visipaque 320-1 ", and reaction formula is following:
2) with the midbody that makes in the step 1) " Visipaque 320-1 " and NaOH prepared in reaction structural formula suc as formula the midbody shown in the III " Visipaque 320-2 ", reaction formula is following:
3) with step 2) in the midbody " Visipaque 320-2 " that makes the prepared in reaction structural formula is suc as formula the Visipaque 320 shown in the V in solvent with alkali, material M, dimerization reaction reagent, reaction formula is following:
4) obtain closing symbol medicinal requirements Visipaque 320 with the Visipaque 320 that makes in the step 3) through recrystallization.
In the described step 1), the solvent in the reaction formula is selected from the combination of Acetyl Chloride 98Min., diacetyl oxide or diacetyl oxide and acetate.
In the described step 1), the catalyzer in the reaction formula is selected from sulfuric acid, methylsulfonic acid or tosic acid.
In the described step 1), reaction adds alkali after accomplishing in reaction system, and alkali wherein is ammoniacal liquor, bicarbonate of ammonia, sodium hydroxide, Pottasium Hydroxide, sodium hydrogencarbonate, yellow soda ash, saleratus or salt of wormwood, acid in the neutralization reaction system and acid anhydrides.
In the described step 3), described dimerization reaction reagent is selected from epoxy chloropropane, 1,3-two chloro-2-hydroxy propanes or 1,3-two bromo-2-hydroxy propanes.
In the described step 3), reaction solvent is selected from water, methyl alcohol or 2-methyl cellosolve.
In the described step 3), the alkali that adds in the reaction is sodium hydroxide, Pottasium Hydroxide or Lithium Hydroxide MonoHydrate.The alkali that adds is one or more in the middle of above-mentioned these alkali.
In the described step 3); The material M that adds in the reaction is weak acid, acidic oxide or hydrogen salt; Described weak acid is selected from acetate, propionic acid, phenol, phenylformic acid, tartrate, toxilic acid, Hydrocerol A or oxysuccinic acid; Described acidic oxide is selected from carbonic acid gas, sulfurous gas or boron trioxide; Described hydrogen salt is selected from SODIUM PHOSPHATE, MONOBASIC, potassium primary phosphate, disodium-hydrogen, potassium phosphate,monobasic, sodium pyrosulfate, sal enixum, sodium hydrogencarbonate or saleratus, and the M that wherein adds in the reaction is one or more in above-mentioned these materials.
In the described step 1), the temperature of reaction is-20 ℃～100 ℃.
In the described step 3), the temperature of reaction is-20 ℃～100 ℃.
Method of the present invention has following technique effect:
1) transformation efficiency is high in the acylation reaction, and degree of purity of production also obviously improves than other technologies.
2) two of compd A aggregate into Visipaque 320 yield height, the liquid yield of product can reach 92% in the reaction.
3) technological operation is simply efficient, and the Visipaque 320 bullion that obtains after the reaction just can obtain the Visipaque 320 of medicinal requirements through simple recrystallization.
Embodiment
Further specify the present invention through following examples at present, but and non-limiting scope of the present invention.
Embodiment 1 preparation Visipaque 320
The preparation method of the Visipaque 320 of present embodiment may further comprise the steps:
1) synthetic intermediate " Visipaque 320-1 ":
Experimental procedure: in reaction kettle, add compound I (4 kg; 5.674 mol), tosic acid (1.08 kg, 5.674 mol), diacetyl oxide (5.36 L) and acetate (530 ml), stir and make dissolving; Stop heating behind the reacting by heating 1h, be cooled to room temperature with ice-water bath.The cooling of external application ice-water bath, slow while stirring dropping ammonia (8 L) is separated out a large amount of white solids.Topple over and liquid, suction filtration is used the distilled water wash solid.Add 8L dissolve with methanol solid, filter cake merges the methyl alcohol phase with 1 L dissolve with methanol.Add anhydrous sodium sulfate drying.Behind the 1h, suction filtration is removed sodium sulfate, the filtrate decompression solvent evaporated, and obtaining white solid is midbody " Visipaque 320-1 " (4.93 kg, yield 95%).
2) synthetic intermediate " Visipaque 320-2 ":
Reactions step: in reaction kettle, add midbody " Visipaque 320-1 " (5.2 kg), methyl alcohol (13 L) and water (2.6 L), stirring and dissolving, dropping sodium solution while stirring, behind reacting by heating 0.5 h, TLC monitors.React completely, regulate pH to 7, stir to separate out and spend the night with concentrated hydrochloric acid.Suction filtration, washing leaching cake, after the drying, obtaining white solid is midbody " Visipaque 320-2 " (4.03 kg, yield 95%).
3) synthetic Visipaque 320:
Reactions step: with Pottasium Hydroxide (112.7g, 2 mol), midbody " Visipaque 320-2 " (1 kg, 1.33mol) (1.25 L) soluble in water.Add potassium primary phosphate (45.5g) and potassium hydrogenphosphate (106.9g) and stir a little while, add epoxy chloropropane (68.1 g, 0.8 mol), behind the stirring reaction 48h, sampling detects, and the HPLC yield of Visipaque 320 is 92%.In reaction system, drip concentrated hydrochloric acid the solution pH value is transferred to 7; Stir 1h after-filtration, washing after adding 3 Kg strong-acid ion exchange resins; Add in the mother liquor and stir 1h after-filtration, washing after 3 kg strong basicity ions change resin; The mother liquor concentrating under reduced pressure is obtained white solid Visipaque 320 bullion, this bullion is obtained white solid Visipaque 320 elaboration 782 g (liquid phase purity is 99.6%) with methyl alcohol and water mixed solvent recrystallization.
Embodiment 2 preparation Visipaque 320s
The preparation method of the Visipaque 320 of present embodiment may further comprise the steps:
1) synthetic intermediate " Visipaque 320-1 ":
In reaction kettle, add compound I (4 kg, 5.674mol), (1.08 kg 5.674mol), acetate chlorine (5.0 L), stir and make dissolving tosic acid, stop heating behind the reacting by heating 1h, are cooled to room temperature with ice-water bath.Ice-water bath, dropping ammonia (8 L) is separated out a large amount of white solids while stirring.Topple over and liquid, suction filtration is used the distilled water wash solid.Add 8 L dissolve with methanol solids, filter cake merges the methyl alcohol phase with 1 L dissolve with methanol.Add anhydrous sodium sulfate drying.Behind the 1h, suction filtration is removed sodium sulfate, the filtrate decompression solvent evaporated, and obtaining white solid is midbody " Visipaque 320-1 " (5.03 kg, yield 97%).
2) according to the method synthetic intermediate among the embodiment 1 " Visipaque 320-2 ".
3) prepare Visipaque 320 according to the method among the embodiment 1.
Embodiment 3 preparation Visipaque 320s
The preparation method of the Visipaque 320 of present embodiment may further comprise the steps:
1) synthetic intermediate " Visipaque 320-1 ":
(1.08g 5.674mol), acetic anhydride (5.5 L), stirs and makes dissolving, stops heating behind the reacting by heating 1h, is cooled to room temperature with ice-water bath in reaction kettle, to add compound I (4 kg, 5.674 mol), tosic acid.The cooling of external application ice-water bath, slow while stirring dropping ammonia (8 L) is separated out a large amount of white solids.Topple over and liquid, suction filtration is used the distilled water wash solid.Add 8 L dissolve with methanol solids, filter cake merges the methyl alcohol phase with 1 L dissolve with methanol.Add anhydrous sodium sulfate drying.Behind the 1h, suction filtration is removed sodium sulfate, the filtrate decompression solvent evaporated, and obtaining white solid is midbody " Visipaque 320-1 " (4.93 g, yield 95%).
2) according to the method synthetic intermediate among the embodiment 1 " Visipaque 320-2 ".
3) prepare Visipaque 320 according to the method among the embodiment 1.
Embodiment 4 preparation Visipaque 320s
The preparation method of the Visipaque 320 of present embodiment may further comprise the steps:
1) synthetic intermediate " Visipaque 320-1 ":
(4 kg 5.674mol), sulfuric acid (326 ml, 6 mol) diacetyl oxides (5.36 L) and acetate (530 ml), stir and make dissolving, stop heating behind the reacting by heating 1h, are cooled to room temperature with ice-water bath in reaction kettle, to add compound I.The cooling of external application ice-water bath, slow while stirring dropping ammonia (8 L) is separated out a large amount of white solids.Topple over and liquid, suction filtration is used the distilled water wash solid.Add 8 L dissolve with methanol solids, filter cake merges the methyl alcohol phase with 1 L dissolve with methanol.Add anhydrous sodium sulfate drying.Behind the 1h, suction filtration is removed sodium sulfate, the filtrate decompression solvent evaporated, and obtaining white solid is midbody " Visipaque 320-1 " (4.93 kg, yield 95%).
2) according to the method synthetic intermediate among the embodiment 1 " Visipaque 320-2 ".
3) prepare Visipaque 320 according to the method among the embodiment 1.
Embodiment 5 preparation Visipaque 320s
The preparation method of the Visipaque 320 of present embodiment may further comprise the steps:
1) synthetic intermediate " Visipaque 320-1 ":
(4 kg 5.674mol), methylsulfonic acid (389 ml, 6 mol), diacetyl oxide (5.36 L) and acetate (530 ml), stir and make dissolving, stop heating behind the reacting by heating 1h, are cooled to room temperature with ice-water bath in reaction kettle, to add compound I.The cooling of external application ice-water bath, slow while stirring dropping ammonia (8 L) is separated out a large amount of white solids.Topple over and liquid, suction filtration is used the distilled water wash solid.Add 8 L dissolve with methanol solids, filter cake merges the methyl alcohol phase with 1 L dissolve with methanol.Add anhydrous sodium sulfate drying.Behind the 1h, suction filtration is removed sodium sulfate, the filtrate decompression solvent evaporated, and obtaining white solid is midbody " Visipaque 320-1 " (4.93g, yield 95%).
2) according to the method synthetic intermediate among the embodiment 1 " Visipaque 320-2 ".
3) prepare Visipaque 320 according to the method among the embodiment 1.
Embodiment 6 preparation Visipaque 320s
The preparation method of the Visipaque 320 of present embodiment may further comprise the steps:
1) synthetic intermediate " Visipaque 320-1 ":
Experimental procedure: in reaction kettle, add compound I (4kg; 5.674 mol), tosic acid (1.08 kg, 5.674 mol), diacetyl oxide (5.36 L) and acetate (530 ml), stir and make dissolving; Stop heating behind the reacting by heating 1h, be cooled to room temperature with ice-water bath.External application ice-water bath cooling slowly drips while stirring slowly dropping sodium solution while stirring, and the pH value of solution is transferred to 7, separates out a large amount of white solids.Topple over and liquid, suction filtration is used the distilled water wash solid.Add 8L dissolve with methanol solid, filter cake merges the methyl alcohol phase with 1 L dissolve with methanol.Add anhydrous sodium sulfate drying.Behind the 1h, suction filtration is removed sodium sulfate, the filtrate decompression solvent evaporated, and obtaining white solid is midbody " Visipaque 320-1 " (4.93 kg, yield 95%).
2) according to the method synthetic intermediate among the embodiment 1 " Visipaque 320-2 ".
3) prepare Visipaque 320 according to the method among the embodiment 1.
Embodiment 7 preparation Visipaque 320s
The preparation method of the Visipaque 320 of present embodiment may further comprise the steps:
1) synthetic intermediate " Visipaque 320-1 ":
Experimental procedure: in reaction kettle, add compound I (4 kg; 5.674 mol), tosic acid (1.08 kg, 5.674 mol), diacetyl oxide (5.36 L) and acetate (530 ml), stir and make dissolving; Stop heating behind the reacting by heating 1h, be cooled to room temperature with ice-water bath.External application ice-water bath cooling slowly drips while stirring and slowly drips sodium carbonate solution while stirring, and the pH value of solution is transferred to 7, separates out a large amount of white solids.Topple over and liquid, suction filtration is used the distilled water wash solid.Add 8L dissolve with methanol solid, filter cake merges the methyl alcohol phase with 1 L dissolve with methanol.Add anhydrous sodium sulfate drying.Behind the 1h, suction filtration is removed sodium sulfate, the filtrate decompression solvent evaporated, and obtaining white solid is midbody " Visipaque 320-1 " (4.93 kg, yield 95%).
2) according to the method synthetic intermediate among the embodiment 1 " Visipaque 320-2 ".
3) prepare Visipaque 320 according to the method among the embodiment 1.
Embodiment 8 preparation Visipaque 320s
The preparation method of the Visipaque 320 of present embodiment may further comprise the steps:
1) synthetic intermediate " Visipaque 320-1 ":
Experimental procedure: in reaction kettle, add compound I (4 kg; 5.674 mol), tosic acid (1.08 kg, 5.674 mol), diacetyl oxide (5.36 L) and acetate (530 ml), stir and make dissolving; Stop heating behind the reacting by heating 1h, be cooled to room temperature with ice-water bath.External application ice-water bath cooling slowly drips while stirring and slowly drips ammonium bicarbonate soln while stirring, and the pH value of solution is transferred to 7, separates out a large amount of white solids.Topple over and liquid, suction filtration is used the distilled water wash solid.Add 8L dissolve with methanol solid, filter cake merges the methyl alcohol phase with 1 L dissolve with methanol.Add anhydrous sodium sulfate drying.Behind the 1h, suction filtration is removed sodium sulfate, the filtrate decompression solvent evaporated, and obtaining white solid is midbody " Visipaque 320-1 " (4.93 kg, yield 95%).
2) according to the method synthetic intermediate among the embodiment 1 " Visipaque 320-2 ".
3) prepare Visipaque 320 according to the method among the embodiment 1.
Execute example 9 preparation Visipaque 320s
According to the method among the embodiment 1 at first synthetic intermediate " Visipaque 320-1 " and midbody " Visipaque 320-2 ", prepare Visipaque 320 according to following reactions step then.
Reactions step: with Pottasium Hydroxide (112.7 g, 2 mol), midbody " Visipaque 320-2 " (1 kg, 1.33 mol) (1.25 L) soluble in water.Add potassium primary phosphate (45.5 g) and potassium hydrogenphosphate (106.9 g) and stir a little while, add 1,3-two chloro-2-hydroxy propanes (0.8 mol), behind the stirring reaction 48h, sampling detects, and the HPLC yield of Visipaque 320 is 90%.In reaction system, drip concentrated hydrochloric acid the solution pH value is transferred to 7; Stir 1 h after-filtration, washing after adding 3 Kg strong-acid ion exchange resins; Add in the mother liquor and stir 1h after-filtration, washing after 3 kg strong basicity ions change resin; The mother liquor concentrating under reduced pressure is obtained white solid Visipaque 320 bullion, this bullion is obtained white solid Visipaque 320 elaboration 770 g (liquid phase purity is 99.6%) with methyl alcohol and water mixed solvent recrystallization.
Embodiment 1O prepares Visipaque 320
According to the method among the embodiment 1 at first synthetic intermediate " Visipaque 320-1 " and midbody " Visipaque 320-2 ", prepare Visipaque 320 according to following reactions step then.
Reactions step: with Pottasium Hydroxide (112.7g, 2 mol), midbody " Visipaque 320-2 " (1 kg; Mol) 1.33 (1.25 L) soluble in water; Add phenol (0.93 mol) and stir a little while, add epoxy chloropropane (0.8 mol), behind stirring reaction 48 h; Sampling detects, and the HPLC yield of Visipaque 320 is 90%.In reaction system, drip concentrated hydrochloric acid the solution pH value is transferred to 7; Stir 1h after-filtration, washing after adding 3 Kg strong-acid ion exchange resins; Add in the mother liquor and stir 1 h after-filtration, washing after 3 kg strong basicity ions change resin; The mother liquor concentrating under reduced pressure is obtained white solid Visipaque 320 bullion, this bullion is obtained white solid Visipaque 320 elaboration 770 g (liquid phase purity is 99.6%) with methyl alcohol and water mixed solvent recrystallization.
Embodiment 11 preparation Visipaque 320s
According to the method among the embodiment 1 at first synthetic intermediate " Visipaque 320-1 " and midbody " Visipaque 320-2 ", prepare Visipaque 320 according to following reactions step then.
Reactions step: with Pottasium Hydroxide (112.7g, 2 mol), midbody " Visipaque 320-2 " (1 kg; Mol) 1.33 (1.25 L) soluble in water; Add Hydrocerol A (0.93 mol) and stir a little while, add epoxy chloropropane (0.8 mol), behind stirring reaction 48 h; Sampling detects, and the HPLC yield of Visipaque 320 is 87%.In reaction system, drip concentrated hydrochloric acid the solution pH value is transferred to 7; Stir 1h after-filtration, washing after adding 3 Kg strong-acid ion exchange resins; Add in the mother liquor and stir 1h after-filtration, washing after 3 kg strong basicity ions change resin; The mother liquor concentrating under reduced pressure is obtained white solid Visipaque 320 bullion, this bullion is obtained white solid Visipaque 320 elaboration 750 g (liquid phase purity is 99.6%) with methyl alcohol and water mixed solvent recrystallization.
Embodiment 12 preparation Visipaque 320s
According to the method among the embodiment 1 at first synthetic intermediate " Visipaque 320-1 " and midbody " Visipaque 320-2 ", prepare Visipaque 320 according to following reactions step then.
Reactions step: with Pottasium Hydroxide (112.7g, 2 mol), midbody " Visipaque 320-2 " (1 kg; Mol) 1.33 (1.25 L) soluble in water; Add boron trioxide (0.93 mol) and stir a little while, add epoxy chloropropane (0.8 mol), behind stirring reaction 48 h; Sampling detects, and the HPLC yield of Visipaque 320 is 92%.In reaction system, drip concentrated hydrochloric acid the solution pH value is transferred to 7; Stir 1h after-filtration, washing after adding 3 Kg strong-acid ion exchange resins; Add in the mother liquor and stir 1h after-filtration, washing after 3 kg strong basicity ions change resin; The mother liquor concentrating under reduced pressure is obtained white solid Visipaque 320 bullion, this bullion is obtained white solid Visipaque 320 elaboration 782 g (liquid phase purity is 99.6%) with methyl alcohol and water mixed solvent recrystallization.
Claims (10)
1. the preparation method of a Visipaque 320 is characterized in that, comprises following reactions step:
1) with structural formula compound shown by formula I 5-amino-2,4,6-three iodo-N, N'-two (2, the 3-dihydroxypropyl)-1, the 3-benzenedicarboxamide is a starting raw material, and the preparation structural formula is suc as formula the midbody shown in the II " Visipaque 320-1 ", and reaction formula is following:
2) with the midbody that makes in the step 1) " Visipaque 320-1 " and NaOH prepared in reaction structural formula suc as formula the midbody shown in the III " Visipaque 320-2 ", reaction formula is following:
3) with step 2) in the midbody " Visipaque 320-2 " that makes the prepared in reaction structural formula is suc as formula the Visipaque 320 shown in the V in solvent with alkali, material M, dimerization reaction reagent, reaction formula is following:
2. the preparation method of Visipaque 320 according to claim 1 is characterized in that, in the described step 1), the solvent in the reaction formula is selected from the combination of Acetyl Chloride 98Min., diacetyl oxide or diacetyl oxide and acetate.
3. the preparation method of Visipaque 320 according to claim 1 is characterized in that, in the described step 1), the catalyzer in the reaction formula is selected from sulfuric acid, methylsulfonic acid or tosic acid.
4. the preparation method of Visipaque 320 according to claim 1; It is characterized in that; In the described step 1), reaction adds alkali after accomplishing in reaction system; Alkali wherein is ammoniacal liquor, bicarbonate of ammonia, sodium hydroxide, Pottasium Hydroxide, sodium hydrogencarbonate, yellow soda ash, saleratus or salt of wormwood, acid in the neutralization reaction system and acid anhydrides.
5. the preparation method of Visipaque 320 according to claim 1 is characterized in that, in the described step 3), described dimerization reaction reagent is selected from epoxy chloropropane, 1,3-two chloro-2-hydroxy propanes or 1,3-two bromo-2-hydroxy propanes.
6. the preparation method of Visipaque 320 according to claim 1 is characterized in that, in the described step 3), reaction solvent is selected from water, methyl alcohol or 2-methyl cellosolve.
7. the preparation method of Visipaque 320 according to claim 1 is characterized in that, in the described step 3), the alkali that adds in the reaction is one or more in sodium hydroxide, Pottasium Hydroxide or the Lithium Hydroxide MonoHydrate.
8. the preparation method of Visipaque 320 according to claim 1; It is characterized in that; In the described step 3); The material M that adds in the reaction is weak acid, acidic oxide or hydrogen salt, and described weak acid is selected from acetate, propionic acid, phenol, phenylformic acid, tartrate, toxilic acid, Hydrocerol A or oxysuccinic acid, and described acidic oxide is selected from carbonic acid gas, sulfurous gas or boron trioxide; Described hydrogen salt is selected from SODIUM PHOSPHATE, MONOBASIC, potassium primary phosphate, disodium-hydrogen, potassium phosphate,monobasic, sodium pyrosulfate, sal enixum, sodium hydrogencarbonate or saleratus, and the M that wherein adds in the reaction is one or more in above-mentioned these materials.
9. the preparation method of Visipaque 320 according to claim 1 is characterized in that, in the described step 1), the temperature of reaction is-20 ℃～100 ℃.
10. the preparation method of Visipaque 320 according to claim 1 is characterized in that, in the described step 3), the temperature of reaction is-20 ℃～100 ℃.
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| CN2012101916586A CN102690212A (en) | 2012-06-12 | 2012-06-12 | Preparation method of iodixanol |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110590591A (en) * | 2019-09-25 | 2019-12-20 | 浙江海洲制药有限公司 | Preparation method of iodixanol and iohexol impurities |
| CN114853625A (en) * | 2022-03-31 | 2022-08-05 | 海南普利制药股份有限公司 | Method for industrially producing iohexol intermediate |
| CN115611761A (en) * | 2022-10-13 | 2023-01-17 | 杭州新曦科技有限公司 | Preparation method of iohexol or iodixanol and intermediate thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101863798A (en) * | 2009-07-21 | 2010-10-20 | 通用电气医疗集团股份有限公司 | Minimizing at the crystallization solvent of the intermediate that is used for non-ionic x-ray contrast agents |
| CN102079716A (en) * | 2009-11-26 | 2011-06-01 | 浙江台州海神制药有限公司 | Preparation and purification of iodixanol |
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2012
- 2012-06-12 CN CN2012101916586A patent/CN102690212A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101863798A (en) * | 2009-07-21 | 2010-10-20 | 通用电气医疗集团股份有限公司 | Minimizing at the crystallization solvent of the intermediate that is used for non-ionic x-ray contrast agents |
| CN102079716A (en) * | 2009-11-26 | 2011-06-01 | 浙江台州海神制药有限公司 | Preparation and purification of iodixanol |
Non-Patent Citations (1)
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| H. PRIEBE ET AL.: "Synthesis, Analysis and Toxicity of Three Compounds Formed during the Synthesis of Iodixanol", 《ACTA CHEMICA SCANDINAVICA》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110590591A (en) * | 2019-09-25 | 2019-12-20 | 浙江海洲制药有限公司 | Preparation method of iodixanol and iohexol impurities |
| CN114853625A (en) * | 2022-03-31 | 2022-08-05 | 海南普利制药股份有限公司 | Method for industrially producing iohexol intermediate |
| CN115611761A (en) * | 2022-10-13 | 2023-01-17 | 杭州新曦科技有限公司 | Preparation method of iohexol or iodixanol and intermediate thereof |
| CN115611761B (en) * | 2022-10-13 | 2023-11-24 | 杭州新曦科技有限公司 | Preparation method of iohexol or iodixanol and intermediate thereof |
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Application publication date: 20120926 |