CN102687727A - Curcumenol and tris-(2-methyl-1-aziridinyl)phosphine oxide compounded antifertility bait formulation for mice - Google Patents

Curcumenol and tris-(2-methyl-1-aziridinyl)phosphine oxide compounded antifertility bait formulation for mice Download PDF

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Publication number
CN102687727A
CN102687727A CN2012101708066A CN201210170806A CN102687727A CN 102687727 A CN102687727 A CN 102687727A CN 2012101708066 A CN2012101708066 A CN 2012101708066A CN 201210170806 A CN201210170806 A CN 201210170806A CN 102687727 A CN102687727 A CN 102687727A
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China
Prior art keywords
antifertility
rcumenol
rate
bait formulation
phosphine oxygen
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Pending
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CN2012101708066A
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Chinese (zh)
Inventor
郭俊平
赵日良
张春美
戴坚
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TIANBAO BIOLOGICAL PREPARATION CO Ltd YANBIAN
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TIANBAO BIOLOGICAL PREPARATION CO Ltd YANBIAN
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Priority to CN2012101708066A priority Critical patent/CN102687727A/en
Publication of CN102687727A publication Critical patent/CN102687727A/en
Priority to PCT/CN2012/083069 priority patent/WO2013177890A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
    • A01N25/004—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits rodenticidal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups A01N57/10, A01N57/18, A01N57/26, A01N57/34
    • A01N57/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups A01N57/10, A01N57/18, A01N57/26, A01N57/34 containing heterocyclic radicals

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses curcumenol and tris-(2-methyl-1-aziridinyl)phosphine oxide compounded antifertility bait formulation for mice. Curcumenol and tris-(2-methyl-1-aziridinyl)phosphine oxide are made into compounded medicine, the cooperation of the curcumenol and the tris-(2-methyl-1-aziridinyl)phosphine oxide is adopted, effects that can not be achieved when the curcumenol or the tris-(2-methyl-1-aziridinyl)phosphine oxide is singly used are achieved, the palatability of bait is good, the bait formulation is rapid to take effect, the effect is obvious, and the bait formulation is convenient to release, pollution-free to the environment, nonhazardous for natural enemies of mice, safe to people and livestock, and beneficial to biological balance maintenance and species diversity protection. The bait formulation controls propagates of injurious mice, injurious rabbits and injurious animals and the population density, and protects forest resources, agricultural resources and animal husbandry resources.

Description

Mouse is with the compound antifertility bait formulation of rcumenol phosphine oxygen aziridine
Technical field
The present invention discloses a kind of mouse with the compound antifertility bait formulation of rcumenol phosphine oxygen aziridine, is used for the bandicoot under the wild environment, the antifertility control of hare, belongs to animal and uses the antifertility drug technical field.
Background technology
At present, adopt to catch and kill with chemicals poisoning measure for the improvement of the plague of rats of forest, farmland, grassland ecology type, hare evil and prevent and treat, means are original; Scientific poor; Particularly adopt chemical rodenticide rodenticide deratization, destroy bio-diversity, destroy the biological food chain of forest; To the natural enemy animal, people, animal, fowl and non-target animals are constituted a threat to serious environment pollution.Use the antifertility medicament control plague of rats,, reduce the muroid population density, resist according to the ecological niche of population and move into suppressing the birth rate of bandicoot population, significant.Also having environmentally safe simultaneously, natural enemy and non-target animals are not had advantages such as injury, is one of non-harmful preventative technology of the most rising advanced person.Like rcumenol or phosphine oxygen aziridine etc., it is not ideal enough to exist single medicine antifertility effect of planting during use with acarpous medicine for traditional mouse, control muroid population density dynamics shortcoming.Even male 70% male sterile can not guarantee control action is played in the whole fertility of population, and the highest female 70% effect that can only reach is seen from probability at all, bisexuality is sterile can be up to 91% antifertility effect.Use the antifertility medicament of bisexuality to produce synergistic effect simultaneously, control muroid population density effect is remarkable.
Summary of the invention
The present invention provides a kind of mouse with the compound antifertility bait formulation of rcumenol phosphine oxygen aziridine, uses rcumenol phosphine oxygen aziridine as main active with mouse, is applied to the plague of rats, the control of hare evil on forest, farmland, grassland, optimizes in the use of chemical raticide agent.
Mouse of the present invention is with the compound antifertility bait formulation of rcumenol phosphine oxygen aziridine, it is characterized in that by following raw materials by weight portion than processing:
0.1 ~ 5 part of rcumenol, 0.05 ~ 3 part of phosphine oxygen aziridine, 92 ~ 100 parts of grain auxiliary materials.
Additive for grains of the present invention comprises cereal crops such as corn, dregs of beans, wheat bran, the cottonseed dregs of rice.
Mouse according to the invention may further comprise the steps with the preparation method of the compound antifertility bait formulation of rcumenol phosphine oxygen aziridine:
1) after 0.1 ~ 5 part of rcumenol adds 2 ~ 10 parts of dissolvings of ethanol, adds 5 ~ 6 parts of additive for grains, mix that to wear into fine powder for use;
2) 0.05 ~ 3 part of phosphine oxygen aziridine adds 5 ~ 6 parts of grain auxiliary materials and mixes that to wear into fine powder for use;
3) in above-mentioned 2 kinds of fine powders, add remaining additive for grains, add water or alcohol granulating and forming, process medicinal bait.
Good effect of the present invention is:Rcumenol and phosphine oxygen aziridine are processed combination drug, utilize both synergies, brought into play them and used the effect of being arrived separately; The medicinal bait good palatability, rapid-action, effect is remarkable; It is convenient to throw in, and environmentally safe is to the nonhazardous of muroid natural enemy; To the person poultry safety, help keeping characteristics such as the ecological balance and protection bio-diversity.Breeding and population density from control bandicoot, evil rabbit, vermin protect forest resources and agricultural, livestock resources.
Embodiment
Embodiment 1
1) after rcumenol 1kg adds ethanol 3kg dissolving, adds the 5kg corn flour, mix that to wear into fine powder for use;
2) phosphine oxygen aziridine 1kg adds the 5kg corn flour, mixes that to wear into fine powder for use;
3) in above-mentioned 2 kinds of fine powders, add the 80kg corn flour, 5kg cottonseed bean cake powder, 5kg wheat bran mixes, and granulating and forming is processed antifertility bait formulation of the present invention.
Embodiment 2
1) after rcumenol 1.5kg adds ethanol 4kg dissolving, adds the 6kg corn flour, mix that to wear into fine powder for use;
2) phosphine oxygen aziridine 0.5kg adds the 6kg corn flour, mixes that to wear into fine powder for use;
3) in above-mentioned 2 kinds of fine powders, add 81kg corn flour, 4kg cottonseed bean cake powder, 5kg wheat bran, mix, granulating and forming is processed antifertility bait formulation of the present invention.
Embodiment 3
1) after rcumenol 2kg adds ethanol 6kg dissolving, adds the 6kg corn flour, mix that to wear into fine powder for use;
2) phosphine oxygen aziridine 0.25kg adds the 5kg corn flour, mixes that to wear into fine powder for use;
3) in above-mentioned 2 kinds of fine powders, add the 82kg corn flour, 4kg cottonseed bean cake powder, 5kg wheat bran mixes, and granulating and forming is processed antifertility bait formulation of the present invention.
Embodiment 4
1) after rcumenol 2.5kg adds ethanol 7kg dissolving, adds the 7kg corn flour, mix that to wear into fine powder for use;
2) phosphine oxygen aziridine 0.2kg adds the 6kg corn flour, mixes that to wear into fine powder for use;
3) in above-mentioned 2 kinds of fine powders, add the 80kg corn flour, 5kg cottonseed bean cake powder, 5kg wheat bran mixes, and granulating and forming is processed antifertility bait formulation of the present invention.
Embodiment 5
1) after rcumenol 3kg adds ethanol 9kg dissolving, adds the 7kg corn flour, mix and wear into fine powder and process the rcumenol antifertility drug;
2) phosphine oxygen aziridine 0.15kg adds the 5kg corn flour, mixes to wear into fine powder and process phosphine oxygen aziridine antifertility drug;
3) in above-mentioned 2 kinds of fine powders, add the 80kg corn flour, 5kg cottonseed bean cake powder, 5kg wheat bran mixes, and granulating and forming is processed antifertility bait formulation of the present invention.
Embodiment 6
1) after rcumenol 5kg adds ethanol 10kg dissolving, adds the 7kg corn flour, mix and wear into fine powder and process the rcumenol antifertility drug;
2) phosphine oxygen aziridine 0.05kg adds the 5kg corn flour, mixes to wear into fine powder and process phosphine oxygen aziridine antifertility drug;
3) in above-mentioned 2 kinds of fine powders, add the 80kg corn flour, 5kg cottonseed bean cake powder, 5kg wheat bran mixes, and granulating and forming is processed antifertility bait formulation of the present invention.
 
Below experiment shows the synergy of antifertility bait formulation of the present invention:
One, mouse is with rcumenol, phosphine oxygen aziridine and the present invention comparative trial to female mouse-anti fertility
Test Example 1
Mouse with the rcumenol antifertility agent respectively to farmland, forest, grassland rat plague control: 2006-2007; Writing brush Zhang Xiang and Shuangyang District Chang Ling, Changchun township carry out farmland plague of rats demonstration test in Dunhua City in Jilin Province agricultural [technology master station; The control area amounts to 15.1 ten thousand mu, bandicoot kind group control effect 39%, the pregnant rate of descent 43% of female one-tenth mouse; Tire rate of descent 25%, subadult rate of descent 31%.To the forest rodent control, the control gross area was 92.8 ten thousand mu in 2006; Grazing rate 62%-77%, muroid is ready to get food, good palatability.The bandicoot pregnancy rate descends 44%, and the tire subnumber descends 7.7%, bandicoot kind group control effect 48%, and the bandicoot population remains on middle low-density level.To the grassland rat plague control, All-China Livestock General Station organized the plague of rats test of rcumenol apholate control grassland in 2007; The station application of Jilin Province livestock breeding office on 14 grassland, 160,000 mu of control areas, bandicoot kind group control effect 47%, pregnant rate descends 44%, tire rate of descent 25%, subadult rate of descent 32%.The small size demonstration test is also carried out at station, province such as Gansu, Qinghai grassland.
Test Example 2
Phosphine oxygen aziridine antifertility medicament is to the control of farmland mouse: the control area was 0.31 ten thousand mu in 2010, and method is that pharmaceutical chemistry concentration is respectively 0.05%, 0.01% and 0.001%, and control group does not have pharmaceutical chemistry; Adopt open mode administration, inspection was caught, cutd open in the dispensing back in 4 weeks, and observation when cuing open inspection is measured its sperm quality to male mouse.0.01% male bandicoot teratospermia 40%, sperm viability is a microinching, sperm quantity 0.51 * 10 6/ ml, fertility-rate 62%, fertility-rate descends 23.5%, open-air bandicoot kind group control effect 18%.The male bandicoot teratospermia 10% of control group, fertility-rate 82%, no bandicoot population control effect.
Test Example 3
The control efficiency of the compound antifertility agent of rcumenol phosphine oxygen aziridine: used rcumenol phosphine oxygen aziridine antifertility bait formulation to prevent and treat 2.2 ten thousand mu of areas in 2011.Pharmaceutical chemistry concentration is 0.21%, and control group does not have pharmaceutical chemistry; The open dispensing of woodland, 4 kilograms of per hectare dosages, rcumenol phosphine oxygen aziridine antifertility bait formulation all has antifertility action to the bisexuality bandicoot; 6 groups of (6 forest lands) administrations of forest land 0.21% concentration group, caught in 5 weeks the dispensing back, catches 50 male and female bandicoots for every group, cuts open inspection, and observation is got one-sided epididymis rapidly and is placed 37 ℃ of constant temperature physiological saline when cuing open inspection, is used to measure sperm concentration and rate of teratosperm.Sperm concentration: the number of sperm in the former seminal fluid of 1 ml (individual/ml)=the interior number of sperm of 25 big grids of smear * 10 (being number of sperm in 1 mm3) * 1000 (being the number of sperm of 1 ml dilute sample) * extension rates.Rate of teratosperm: with 1% semen smear, fix with 95% ethanol after the air drying, add Eosinum Natricum, 20 min that dye, the coloring agent that flush away is unnecessary, air is dry, and * 400 times of mirrors are observed down.At least 200 sperms of random observation: abnormal rate=(teratosperm number/sum) * 100%.
The 1st group of investigation result, conceived rate of descent 73%, the young rate of descent 22% of tire, subadult rate of descent 75%, rate of teratosperm 68%, sperm viability is motionless, sperm quantity 0.21 * 106, fertility-rate 0.The 2nd group, conceived rate of descent 75%, the young rate of descent 32% of tire, subadult rate of descent 75%, rate of teratosperm 78%, sperm viability is motionless, sperm quantity 0.19 * 106, fertility-rate 5.The 3rd group of conceived rate of descent 75%, the young rate of descent 30% of tire, subadult rate of descent 78%, rate of teratosperm 73%, sperm viability is motionless, sperm quantity 0.20 * 106, fertility-rate 6., the 4th group, conceived rate of descent 80%, the young rate of descent 30% of tire, subadult rate of descent 80%, rate of teratosperm 72%, sperm viability is motionless, sperm quantity 0.21 * 106, fertility-rate 3.The 5th group, conceived rate of descent 80%, the young rate of descent 32% of tire, subadult rate of descent 78%, rate of teratosperm 69%, sperm viability is motionless, sperm quantity 0.23 * 106, fertility-rate 2.The 6th group, conceived rate of descent 81%, the young rate of descent 40% of tire, subadult rate of descent 75%, rate of teratosperm 76%, sperm viability is motionless, sperm quantity 0.20 * 106, fertility-rate 1.The female mouse development of ovary is unusual, the ovarian follicle diapause; Bandicoot uterus organ coefficient raises, the uterus oedema, the oedema degree with get food dosage and be proportionate; To male mouse, bandicoot sperm viability, density, survival rate reduce, and rate of teratosperm rises, and teratosperm shows as the acrosomal cap disappearance; Rcumenol phosphine oxygen nitrogen third pharmaceutical chemistry does not have influence to the ontogeny of male and female bandicoot.Investigation result is bandicoot pregnancy rate decline 73%-81%, tire subnumber decline 22-40%, and subadult rate of descent 73-80%, the total effect 88% of open-air bandicoot kind group control, the bandicoot population remains on stable low-density level.
Rcumenol, phosphine oxygen aziridine and the present invention are to the comparative trial table of female mouse-anti fertility
Divide into groups Conceived rate of descent Tire rate of descent The subadult rate of descent Bandicoot population control rate
Rcumenol 44 25 32 47
Phosphine oxygen aziridine ? ? ? 18
Embodiment 1 73 22 75 88 (the present invention)
Embodiment 2 75 32 75 88
Embodiment 3 75 30 78 88
Embodiment 4 80 30 80 88
Embodiment 5 80 32 78 88
Embodiment 6 81 40 75 88
Conclusion: rcumenol can cause atrophy of corpus iuteum, the cytoplasm dissolving of female mouse palace body, replaces for connective tissue gradually.Medicament makes endometrium that the decidua reaction no longer take place, and the secretory phase is suppressed, and decidua and embryo come off in uterine cavity.Rcumenol has destroyed decidua and the chorion tissue makes it transformation so that necrosis continues and generation endogenous prostaglandin reinforcement uterine contractile, finally causes miscarriage and infertile.
Two, Mouse is with rcumenol, phosphine oxygen aziridine and the present invention comparative trial to the male mouse antifertility
Comparative trial table to the male mouse antifertility
Divide into groups Rate of teratosperm Sperm viability Sperm quantity/ml/10g Fertility-rate Bandicoot population control rate
Rcumenol 11 Propulsion 0.83×10 6 78 44
Phosphine oxygen aziridine 40 Microinching 0.51×10 6 62 18
Embodiment 1 68 Motionless 0.21×10 6 0 88 (the present invention)
Embodiment 2 78 Motionless 0.19×10 6 5 88
Embodiment 3 73 Motionless 0.20×10 6 6 88
Embodiment 4 72 Motionless 0.21×10 6 3 88
Embodiment 5 69 Motionless 0.23×10 6 2 88
Embodiment 6 76 Motionless 0.20×10 6 1 88
Three, conclusion:
The present invention utilizes rcumenol and phosphine oxygen aziridine synergy, causes female bandicoot miscarriage and infertile, and pregnancy rate, the young rate of tire descend obviously, and male mouse is caused the sexual gland damage, and gamete generation obstacle causes male sterile.Male mouse sperm viability, density, survival rate reduce, and rate of teratosperm rises significantly, and teratosperm shows as the acrosomal cap disappearance, and the amorphous head deformity that waits is in the majority, and its drug effect is far longer than the independent result of use sum of these two kinds of medicines.In addition, female mouse is also had significant genotoxicity, and can reach filial generation, have a strong impact on the fecundity of the male mouse of filial generation, and cause the male sterile dual antifertility effect of filial generation through placenta and milk.Synergy makes its antifertility effect extremely remarkable.

Claims (3)

1. a mouse is characterized in that with the compound antifertility bait formulation of rcumenol phosphine oxygen aziridine with rcumenol, phosphine oxygen aziridine be main component, and its ratio of weight and number is following:
0.1 ~ 5 part of rcumenol, 0.05 ~ 3 part of phosphine oxygen aziridine, 92 ~ 100 parts of additive for grains.
2. mouse according to claim 1 is with rcumenol, phosphine oxygen aziridine antifertility bait formulation, and it is characterized in that: additive for grains comprises cereal crops such as corn, dregs of beans, wheat bran, the cottonseed dregs of rice.
3. according to the preparation method of the said mouse of claim 1, may further comprise the steps with the compound antifertility bait formulation of rcumenol phosphine oxygen aziridine:
1) after 0.1 ~ 5 part of rcumenol adds 2 ~ 10 parts of dissolvings of ethanol, adds 5 ~ 6 parts of additive for grains, mix that to wear into fine powder for use;
2) 0.05 ~ 3 part of phosphine oxygen aziridine adds 5 ~ 6 parts of grain auxiliary materials and mixes that to wear into fine powder for use;
3) in above-mentioned 2 kinds of fine powders, add remaining additive for grains, add water or alcohol granulating and forming, process medicinal bait.
CN2012101708066A 2012-05-29 2012-05-29 Curcumenol and tris-(2-methyl-1-aziridinyl)phosphine oxide compounded antifertility bait formulation for mice Pending CN102687727A (en)

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CN2012101708066A CN102687727A (en) 2012-05-29 2012-05-29 Curcumenol and tris-(2-methyl-1-aziridinyl)phosphine oxide compounded antifertility bait formulation for mice
PCT/CN2012/083069 WO2013177890A1 (en) 2012-05-29 2012-10-17 Rodent composite antifertility bait containing curcumol and phosphine oxide aziridine

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013177890A1 (en) * 2012-05-29 2013-12-05 延边天保生物制剂有限公司 Rodent composite antifertility bait containing curcumol and phosphine oxide aziridine
CN111466394A (en) * 2020-03-10 2020-07-31 延边天保生物制剂有限公司 Curcumol bait for mice and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1875713A (en) * 2005-06-09 2006-12-13 北京贵千金医药科技有限公司 Anti-fertility raticide utilizing phosphinyloxy aziridine for deratization and prescription thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100491379C (en) * 2005-03-30 2009-05-27 延边天保生物制剂有限公司 Method for extracting curcumcnol, antifertility drug with curcumenol as main active ingredient for rats
CN101869113B (en) * 2010-06-17 2013-09-04 中国农业科学院植物保护研究所 Cyclodextrin inclusion compound of rodents sterilant and preparation method thereof
CN102687727A (en) * 2012-05-29 2012-09-26 延边天保生物制剂有限公司 Curcumenol and tris-(2-methyl-1-aziridinyl)phosphine oxide compounded antifertility bait formulation for mice

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1875713A (en) * 2005-06-09 2006-12-13 北京贵千金医药科技有限公司 Anti-fertility raticide utilizing phosphinyloxy aziridine for deratization and prescription thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
姚丹丹等: "《植物保护与农产品质量安全》", 30 November 2007, article "鼠类不育剂的研究与应用", pages: 309-311 *
李悦等: "0.2%莪术醇饵剂防治森林害鼠试验研究", 《长春大学学报》, vol. 20, no. 04, 30 April 2010 (2010-04-30), pages 20 - 22 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013177890A1 (en) * 2012-05-29 2013-12-05 延边天保生物制剂有限公司 Rodent composite antifertility bait containing curcumol and phosphine oxide aziridine
CN111466394A (en) * 2020-03-10 2020-07-31 延边天保生物制剂有限公司 Curcumol bait for mice and preparation method thereof

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