CN102671269A - 流体传送装置 - Google Patents
流体传送装置 Download PDFInfo
- Publication number
- CN102671269A CN102671269A CN2012100330445A CN201210033044A CN102671269A CN 102671269 A CN102671269 A CN 102671269A CN 2012100330445 A CN2012100330445 A CN 2012100330445A CN 201210033044 A CN201210033044 A CN 201210033044A CN 102671269 A CN102671269 A CN 102671269A
- Authority
- CN
- China
- Prior art keywords
- piston
- shell
- transferring fluid
- housing
- outlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 75
- 230000007246 mechanism Effects 0.000 claims abstract description 49
- 238000003860 storage Methods 0.000 claims abstract description 6
- 238000007599 discharging Methods 0.000 claims abstract description 5
- 210000003811 finger Anatomy 0.000 claims description 22
- 238000007789 sealing Methods 0.000 claims description 22
- 210000003813 thumb Anatomy 0.000 claims description 22
- 230000005540 biological transmission Effects 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 5
- 230000000452 restraining effect Effects 0.000 abstract description 21
- 230000033001 locomotion Effects 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 3
- 230000001960 triggered effect Effects 0.000 abstract 2
- 210000003928 nasal cavity Anatomy 0.000 description 27
- 239000003814 drug Substances 0.000 description 21
- -1 Dilauid Chemical compound 0.000 description 13
- 239000002585 base Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 8
- 230000008676 import Effects 0.000 description 7
- 125000006850 spacer group Chemical group 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 229920001903 high density polyethylene Polymers 0.000 description 5
- 239000004700 high-density polyethylene Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 4
- 210000001364 upper extremity Anatomy 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 3
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 3
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 3
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 229920006324 polyoxymethylene Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 229960002052 salbutamol Drugs 0.000 description 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
- 229920002943 EPDM rubber Polymers 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 229920000106 Liquid crystal polymer Polymers 0.000 description 2
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 description 2
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229960004495 beclometasone Drugs 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 229960000265 cromoglicic acid Drugs 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 2
- 239000013013 elastic material Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 230000009969 flowable effect Effects 0.000 description 2
- 229960000676 flunisolide Drugs 0.000 description 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- LRMHVVPPGGOAJQ-UHFFFAOYSA-N methyl nitrate Chemical compound CO[N+]([O-])=O LRMHVVPPGGOAJQ-UHFFFAOYSA-N 0.000 description 2
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 229960000195 terbutaline Drugs 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 description 1
- DHPRQBPJLMKORJ-XRNKAMNCSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O DHPRQBPJLMKORJ-XRNKAMNCSA-N 0.000 description 1
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- NDAUXUAQIAJITI-LBPRGKRZSA-N (R)-salbutamol Chemical compound CC(C)(C)NC[C@H](O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-LBPRGKRZSA-N 0.000 description 1
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 1
- LZAMLBFWTLFDKM-UHFFFAOYSA-N 1-(propan-2-ylamino)ethanol Chemical class CC(C)NC(C)O LZAMLBFWTLFDKM-UHFFFAOYSA-N 0.000 description 1
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 description 1
- LNETULKMXZVUST-UHFFFAOYSA-N 1-naphthoic acid Chemical compound C1=CC=C2C(C(=O)O)=CC=CC2=C1 LNETULKMXZVUST-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- ALKYHXVLJMQRLQ-UHFFFAOYSA-M 3-carboxynaphthalen-2-olate Chemical compound C1=CC=C2C=C(C([O-])=O)C(O)=CC2=C1 ALKYHXVLJMQRLQ-UHFFFAOYSA-M 0.000 description 1
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical class CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- RPHLQSHHTJORHI-UHFFFAOYSA-N Adrenochrome Chemical compound O=C1C(=O)C=C2N(C)CC(O)C2=C1 RPHLQSHHTJORHI-UHFFFAOYSA-N 0.000 description 1
- 229930003347 Atropine Natural products 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 102000051325 Glucagon Human genes 0.000 description 1
- 108060003199 Glucagon Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229920000459 Nitrile rubber Polymers 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229920002253 Tannate Polymers 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 102400000336 Thyrotropin-releasing hormone Human genes 0.000 description 1
- 101800004623 Thyrotropin-releasing hormone Proteins 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
- WHRVRSCEWKLAHX-LQDWTQKMSA-N benzylpenicillin procaine Chemical compound [H+].CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 WHRVRSCEWKLAHX-LQDWTQKMSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 229960004436 budesonide Drugs 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000000080 chela (arthropods) Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 229960001338 colchicine Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 235000000639 cyanocobalamin Nutrition 0.000 description 1
- 239000011666 cyanocobalamin Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 229940009662 edetate Drugs 0.000 description 1
- 229950005627 embonate Drugs 0.000 description 1
- 229920006351 engineering plastic Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 229960004943 ergotamine Drugs 0.000 description 1
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 description 1
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 description 1
- 229950007655 esilate Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 description 1
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002714 fluticasone Drugs 0.000 description 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
- 229960000289 fluticasone propionate Drugs 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 229960002848 formoterol Drugs 0.000 description 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940050411 fumarate Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 229960001731 gluceptate Drugs 0.000 description 1
- KWMLJOLKUYYJFJ-VFUOTHLCSA-N glucoheptonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O KWMLJOLKUYYJFJ-VFUOTHLCSA-N 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 229920005555 halobutyl Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229960001067 hydrocortisone acetate Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229960001361 ipratropium bromide Drugs 0.000 description 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 229940039009 isoproterenol Drugs 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 229940099584 lactobionate Drugs 0.000 description 1
- JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-M mandelate Chemical compound [O-]C(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-M 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- HNJJXZKZRAWDPF-UHFFFAOYSA-N methapyrilene Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CS1 HNJJXZKZRAWDPF-UHFFFAOYSA-N 0.000 description 1
- 229960001869 methapyrilene Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940102396 methyl bromide Drugs 0.000 description 1
- 229960001664 mometasone Drugs 0.000 description 1
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- SEEHQOJBHGOFRE-UHFFFAOYSA-N n-[hydroperoxy(phenyl)arsoryl]oxyacetamide Chemical compound CC(=O)NO[As](=O)(OO)C1=CC=CC=C1 SEEHQOJBHGOFRE-UHFFFAOYSA-N 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 1
- PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- 229940014662 pantothenate Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229960000395 phenylpropanolamine Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229960005414 pirbuterol Drugs 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000003109 potassium Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940095783 procaine benzylpenicillin Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
- 229960001457 rimiterol Drugs 0.000 description 1
- IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229920006132 styrene block copolymer Polymers 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
- 229960003708 sumatriptan Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
- B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
- B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
- B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
- B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
- B05B1/3436—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a plane perpendicular to the outlet axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
- B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
- B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
- B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
- B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
- B05B1/3447—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a cylinder having the same axis as the outlet
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1001—Piston pumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
- B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Mechanical Engineering (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Reciprocating Pumps (AREA)
Abstract
本发明涉及流体传送装置,其包括:具有以排出流体的出口的壳体;包括限定以存储流体的泵腔的外壳、能相对泵腔滑移的活塞、活塞柱塞和以将从泵腔排出的流体传送到壳体的出口的传送通道的活塞泵;作用在活塞泵的外壳上以朝向壳体的出口偏压外壳的偏压机构;包括在活塞泵的外壳上或连接到该外壳的捕获构件和能由可手动致动的触发器移动的约束构件的触发机构,其借助可手动致动的触发器的操作而能从待触发构造移至触发构造;在待触发构造,约束构件与捕获构件接合以防止外壳朝壳体的出口移动而防止流体从泵腔排出;在触发构造,约束构件与捕获构件脱离接合,以使外壳能在偏压机构作用下朝壳体的出口移动而将流体沿传送通道从泵腔排出壳体的出口之外。
Description
技术领域
本公开内容涉及流体传送装置。具体地,本公开内容涉及用于鼻腔、舌下或眼部使用的流体传送装置。
背景技术
流体传送装置被公知用于分配诸如粉末和流体等介质,以排出到身体内或排出到身体上。EP1219356公开了一种这样的装置,在该装置中,活塞泵被用于将可流动的介质从贮存器排出到出口喷嘴之外,从而进行鼻腔传送。为了操作该装置,使用者手动地将贮存器相对于支承表面向上移位,以使针在贮存器的密封活塞中形成开口。使用者对贮存器的进一步手动运动使活塞在贮存器内移位,以将可流动的介质加压并且使该介质经由所述针排出。
WO2004/069664公开了一种适于在具有活塞泵的流体传送装置中使用的封闭构件。该封闭构件不需要由针刺穿。而是,该封闭构件上的一个或更多个弹性凸起部被用来密封存储容器。致动时,封闭构件相对于存储容器的手动移位使得该一个或更多个弹性凸起部变形,从而适应流体从该存储容器的流出。
在这两种情形中,所述装置依赖于活塞泵的至少一部分的手动移位来进行操作。这会导致介质从该装置不均匀地排出。原因包括由不同的使用者施加到活塞泵的不同的推力和负载以及使用者在释放该装置之前可能将不会完整地完成活塞泵所需的行程。
发明内容
根据本公开内容,提供了一种用于排出流体的流体传送装置,所述流体传送装置包括:
壳体;
活塞泵;
偏压机构;以及
触发机构,
所述壳体包括用于排出所述流体的出口;
所述活塞泵包括限定用于存储所述流体的泵腔的外壳、能够相对于所述泵腔以滑动的方式移动的活塞、活塞柱塞以及传送通道,所述传送通道用于将从所述泵腔排出的流体传送到所述壳体的所述出口;
所述偏压机构作用在所述活塞泵的所述外壳上,以朝向所述壳体的所述出口偏压所述外壳;
所述触发机构包括捕获构件和约束构件,所述捕获构件位于所述活塞泵的所述外壳上或被连接到所述外壳,所述约束构件能够由可手动致动的触发器移动;
所述触发机构借助所述可手动致动的触发器的操作而能够从待触发构造(cockedconfiguration)移动到触发构造;
其中,在所述待触发构造中,所述约束构件与所述捕获构件接合以防止所述外壳朝向所述壳体的所述出口移动,从而防止流体从所述泵腔排出;并且
在所述触发构造中,所述约束构件与所述捕获构件脱离,以使所述外壳能够在所述偏压机构的作用下从朝向所述壳体的所述出口移动,从而将流体沿所述传送通道从所述泵腔排出所述壳体的所述出口之外。
有利地,所述流体传送装置的操作是简单且一致的。对触发机构与偏压机构的组合使用使得将可预测的加载和动力施加到活塞泵的外壳上。此外,该装置确保活塞泵在偏压机构的作用下经历完整排出行程。由此,防止部分排出。
所述约束构件可以是柔性的。所述约束构件可以由具有弹性变形能力的材料形成。
所述触发机构可包括两个约束构件。
所述两个约束构件可大致垂直于所述活塞泵的所述外壳的纵向轴线横穿所述壳体。
所述两个约束构件可位于所述外壳的两侧。由此,所述约束构件能够起作用以通过与所述外壳的捕获构件接合而将所述外壳捕获在所述约束构件之间。
在一个方面,所述两个约束构件可包括一对臂,这一对臂在所述待触发构造中彼此向外弓起,并且这一对臂能够彼此远离地挠曲以使所述触发机构能够移动到所述触发构造。该对臂在待触发构造中可被朝向所述外壳向内偏压,以确保与所述捕获构件的可靠接合。通过确保在待触发构造中该对臂从中立位置略向外挠曲而处于一定应变下,可产生这种偏压作用。
所述可手动致动的触发器可包括拇指垫和其它手指垫(finger pad),该拇指垫和其它手指垫在使用时能够朝向彼此被挤压。该拇指垫和其它手指垫可被定位在壳体的相对两侧。该拇指垫和其它手指垫可以具有相同的尺寸和构造,并且其它手指垫可由拇指操作并且拇指垫可由其它手指操作。该拇指垫和其它手指垫均可相对于壳体向内移动。另选地,仅一个衬垫可相对于壳体向内移动,而另一衬垫保持静止。在这种情况下,静止衬垫可形成为壳体的一体部分。所述可手动致动的触发器可仅包括一个衬垫。在这种情况下,该触发器的一个或更多个约束臂可从可动衬垫经过该装置的内部延伸而与壳体接触或与该壳体中的其它抵接部接触。
所述拇指垫和所述其它手指垫可与所述约束构件一体形成。
在一个方面,当所述约束构件呈一对臂的形式时,所述拇指垫和所述其它手指垫可与所述两个约束构件一体形成。有利地,所述拇指垫、所述其它手指垫以及所述两个约束臂作为单个模制品的一体构形降低了制造成本和组装成本。
所述捕获构件可包括所述外壳的向外延伸的凸缘。所述捕获构件可采用其它形式,例如一个或更多个凸起部、***部、齿等等。所述捕获构件可与所述外壳一体形成,或者可以是通过合适手段(例如,焊接、压接、粘合等)操作连接到所述外壳的分离部件。
所述活塞和所述活塞柱塞可相对于所述壳体被固定。由此,所述活塞泵的所述外壳在被致动时可移动。
所述活塞和所述活塞柱塞可一体形成。然而,优选地,所述活塞柱塞与所述活塞形成为分离部件。在组装时,所述活塞和所述活塞柱塞彼此密封地配合。
所述偏压机构可包括在所述壳体和所述外壳之间作用的弹簧。所述弹簧可直接接触所述壳体和所述外壳。另选地,可提供一个或更多个中间构件以将弹簧力传送到所述外壳。
所述外壳可包括远离所述壳体的所述出口延伸的支柱,所述支柱形成用于接收所述弹簧的一端的座部。
所述活塞可包括主体以及至少一个弹性凸起部,所述至少一个弹性凸起部在所述待触发构造中密封所述泵腔;在所述触发构造中,当所述外壳朝向所述壳体的所述出口移动时,由于所述泵腔内形成的压力增大,所述至少一个弹性凸起部能够偏转,从而适应所述流体从所述泵腔到所述传送通道内的排出。
所述至少一个弹性凸起部可仅围绕所述活塞的外周的一部分延伸。
与所述至少一个弹性凸起部轴向对准的至少一个密封凸起部可围绕所述活塞的所述外周的其余部分延伸。
所述活塞可包括彼此轴向间隔开的三个弹性凸起部,每个弹性凸起部仅围绕所述活塞的外周的一部分延伸,所述活塞还包括三个密封凸起部,每个密封凸起部与所述三个弹性凸起部中的一个轴向对准并且围绕活塞的所述外周的其余部分延伸。
所述流体传送装置还可包括至少一个第二密封凸起部,所述第二密封凸起部围绕所述活塞的全部外周延伸。
所述流体传送装置可包括上壳体和下壳体,所述上壳体限定所述出口,所述下壳体可连接到所述上壳体以限定所述装置的用于容纳所述活塞泵和所述偏压机构的内部。
所述上壳体和所述下壳体可包括连接机构,所述连接机构能够使所述上壳体和所述下壳体在局部组装的构造中被连接到一起,在所述局部组装的构造中,所述活塞泵和所述偏压机构跨接在所述上壳体和所述下壳体之间,其中所述偏压机构处于相对低压缩的第一状态;其中,通过将所述上壳体和所述下壳体进一步移动到一起以将所述偏压机构压缩到相对高压缩的第二状态,所述连接机构还能够使所述上壳体和所述下壳体被完全组装。
所述连接机构可包括位于所述上壳体和所述下壳体中的一个上的至少一个挡块以及位于所述上壳体和所述下壳体中的另一个上的两组孔,每组至少一个孔,其中,所述两组孔彼此轴向间隔开。
所述流体传送装置可以是一次性装置。
所述流体传送装置可以是鼻腔装置、舌下装置或眼部装置。
还提供一种如上所述的流体传送装置,该流体传送装置结合被容纳在所述泵腔中的单剂量流体使用。所述流体可包含药剂。
如本文所使用的,术语“药剂”旨在包含能够被递送或施用给人或动物的任何药剂、化合物、组合物、药物、试剂或制品,例如药剂、药品、生物制品和医药制品。示例包括抗过敏药、止痛剂、支气管扩张剂、抗组胺剂、治疗性蛋白质和肽、镇咳药、心绞痛制剂、抗生素、消炎制剂、激素或磺胺,例如,血管收缩胺、酶、生物碱或类固醇,包括它们中的两种或更多种的组合。具体地,示例包括:异丙基肾上腺素[α-(异丙基氨基甲基)原儿茶醇]、苯肾上腺素、苯丙醇胺、胰高血糖素、肾上腺素红、胰蛋白酶、肾上腺素、麻黄碱、那可汀、可待因、阿托品、肝素、***、二氢***酮、麦角胺、东莨菪碱、美沙吡啉、氰钴维生素、特布他林、利米特罗、沙丁胺醇、异丙托溴铵和沙丁胺醇、氟尼缩松、秋水仙碱、吡布特罗、倍氯米松、奥西那林、芬太尼以及二乙酰***,链霉素、青霉素、普鲁卡因青霉素、四环素、氯四环素和羟四环素,促肾上腺皮质激素和肾上腺皮质激素(例如可的松、氢化可的松、醋酸氢化可的松和波尼松龙)、胰岛素、色甘酸钠和莫米松,包括它们中的两种或更多种的组合。
该药剂可作为游离碱使用或者作为本领域中常规的一种或更多种盐使用,例如,醋酸盐、苯磺酸盐、甲苯酸盐、碳酸氢盐、洒石酸氢盐、溴化物、乙二胺四乙酸钙、右旋樟脑磺酸、碳酸盐、氯化物、柠檬酸盐、二氢氯化物、乙二胺四乙酸盐、乙二磺酸盐、丙酸酯月桂硫酸盐、乙磺酸盐、延胡索酸盐、葡庚糖酸盐(fluceptate)、葡萄糖酸盐、谷氨酸盐、对羟乙酰氨基苯胂酸盐、己基间苯二酚盐、氢溴酸盐、盐酸盐、羟萘甲酸盐、碘化物、羟乙基磺酸盐、乳酸盐、乳糖醛酸盐、苹果酸盐、马来酸盐、扁桃酸盐、甲磺酸盐、甲基溴化物(methylbromide)、甲基硝酸盐(methylnitrate)、甲基硫酸盐(methylsulphate)、粘酸盐、萘磺酸盐、硝酸盐、扑酸盐(双羟萘酸盐)、泛酸盐、磷酸盐、二磷酸盐、聚半乳糖醛酸盐、水杨酸盐、硬脂酸盐、碱式醋酸盐、琥珀酸盐、硫酸盐、单宁酸盐、酒石酸盐和三乙基碘,包括它们中的两种或更多种的组合。还可以使用阳离子盐,例如碱金属(例如,钠和钾)盐和铵盐,以及本领域已知的药剂可接受的胺(例如,甘氨酸、乙二胺、胆碱、二乙醇胺、三乙醇胺、十八胺、二乙胺、三乙胺、1-氨基-2-丙醇-氨基-2-(羟甲基)丙烷-1,3-二醇和1-(3,4-二羟基苯基)-2异丙基氨基乙醇)的盐。
药剂通常是这样的药剂:该药剂适于鼻腔吸入并且为此目的能够以任何合适合的流体形式被提供,例如作为溶液或溶剂或载体液体(例如,乙醇或异丙醇)中的粉末悬浮体。另选地,该药剂可以是适于舌下或眼部递送的药剂。
药剂可以是例如适于治疗哮喘的药剂。示例包括沙丁胺醇、倍氯米松、沙美特罗、氟替卡松、福莫特罗、特布他林、色甘酸钠、布地缩松和氟尼缩松、以及生理上可接受的盐(例如,硫酸沙丁胺醇、昔萘酸沙美特罗、丙酸氟替卡松、二丙酸倍氯米松、硫酸特布他林)、溶剂化物和酯,包括它们中的两种或更多种的组合。还能够使用单种同分异构体,例如R-沙丁胺醇。药剂可以是例如适于治疗偏头痛的药剂。示例是舒马普坦。如将被理解的,药剂可包含一种或更多种活性组分,该活性组分的示例是flutiform。需要的话,可包含一种或更多种表面活性剂。
所述活塞可由弹性体或热塑性弹性体材料制成,所述弹性体或热塑性弹性体材料例如EPDM、聚氯丁二烯、氢化丁腈橡胶、丁基橡胶、卤化丁基橡胶、动态交联的EPDM/PP苯乙烯嵌段共聚物或者它们的混合物。其它合适材料包括高密度聚乙烯和低密度聚乙烯。所述壳体可由工程塑料(例如,聚丙烯、HDPE、ABS、聚酯或POM)制成。
活塞泵的外壳可由任何合适材料制成,所述材料例如为玻璃、环烯烃共聚物(一个例子是可从德国的TOPAS Advanced Polymers GmbH获得的COC)或液晶聚合物(一个例子是可从美国威明顿的DuPont获得的LCP)。所述捕获构件可在上述外壳的外部上形成为模制构形或机加工构形。
所述约束构件以及可手动致动的触发器可由具有必要挠曲特征的合适材料制成(优选地,制成为单件模制品),所述材料例如聚丙烯、HDPE、ABS、聚酯或POM。
附图说明
现将参照附图仅以实施例的方式来描述本公开内容的实施方式,在附图中:
图1是根据本公开内容的第一鼻腔装置的立体图;
图2是图1的鼻腔装置的立体图,其中上壳体被移除;
图3是图1的鼻腔装置的立体图,其中下壳体被移除;
图4是图1的鼻腔装置的立体图,其中上壳体和下壳体均被移除;
图5是图1的鼻腔装置的剖视图;
图6是图1的鼻腔装置的活塞泵的剖视图;
图7是图1的鼻腔装置的活塞的立体图;以及
图8是根据本公开内容的第二鼻腔装置的壳体的剖视图。
具体实施方式
在下文中,将仅以实施例的方式描述作为适于流体的鼻腔传送的装置的流体传送装置。
如附图1至图7所示,第一鼻腔装置1包括上壳体2、下壳体3、活塞泵4、弹簧5以及触发机构6。
该装置的壳体由两个部分,即由上壳体2和下壳体3形成。如图5最佳地所示,上壳体2和下壳体3在界面18处连接在一起,这种连接可以是卡配合连接或者例如可以是超声波焊接连接。该壳体限定用于容纳装置1的其余部件的内部。上壳体2和下壳体3一起限定壳体的侧壁13、底座16以及与该底座相对的鼻腔件11,该鼻腔件11朝向出口孔10向上延伸,该出口孔10设置在鼻腔件11的远端。在鼻腔件11和侧壁13之间设置肩部12。两个大体上为椭圆形的衬垫孔14设置在壳体的侧壁13的相对两侧,衬垫孔的用途将在下文进一步描述。如在图5的剖视图中最佳地所示,上壳体2设置有向内导向的管状延伸部15,该延伸部15从鼻腔件11的上端向下延伸到装置1的内部中。在该装置的相对端,下壳体3设置有一对向上延伸的凸起部17,该对凸起部17用作弹簧座部,如将在下文进一步描述。此外,如图2最佳地所示,一对衬垫支承腹板19位于下壳体3的底端并且从侧壁13大体垂直地朝向装置1的中心延伸。衬垫支承腹板19的用途将在下文进一步描述。
活塞泵4在图6中被示出,并且包括容器20、活塞21以及柱塞22。
容器20包括大致为筒状的主体30,该主体30在一端具有封闭基座32并且在与基座32相反的一端具有上部开口31。容器20限定泵腔35,在使用中流体在通过操作装置1而被排出之前可被存储在该泵腔35中。朝向主体30的基座32定位有朝外的凸缘34,该凸缘34的用途将在下文被进一步描述。如图6所示和如图5中所组装的,柱延伸部33从基座32轴向延伸,该柱延伸部33用作弹簧5的上端的座部。
活塞21包括活塞主体40,活塞主体40在图7中被更详细地示出。活塞主体40总体上是柱状的但是设置有许多用于执行各种功能的成形区域和凸起部。三个弹性凸起部41沿活塞主体40的下半部轴向间隔开地设置。每个弹性凸起部41均围绕活塞主体40的外周的一部分周向延伸。在所示的实施方式中,弹性凸起部41延伸经过大约100度的弧。弹性凸起部41在径向方向上相对深,并且凸起部41的该相对大的径向深度使得它们与将在下文描述的其它密封构型相比相对柔韧。活塞主体40还设置有三个密封凸起部42,这三个密封凸起部42均与其中一个弹性凸起部41轴向对准并且被形成为弹性凸起部41的向外径向边缘的周向延伸部。每个密封凸起部42均围绕活塞主体40的外周的不与弹性凸起部41的扇形重合的其余部分延伸。因此在所示的实施方式中,每个密封凸起部42均绕大约260度的弧延伸。密封凸起部42径向延伸略超出活塞主体40的外表面。由于密封凸起部42的径向方向上的“深度”与弹性凸起部41的深度相比相对较小,因此密封凸起部的柔性相对要小得多。
活塞主体40还包括三个密封环43,这三个密封环43设置在活塞主体40的上端并且彼此轴向间隔开。在密封环43和弹性凸起部41之间设置有进口46,如图5所示,该进口46与活塞主体40的内部中的横向导管44连通。横向导管44继而与轴向取向的轴向导管45连通,该轴向导管45向上延伸经过活塞主体40的上半部并且终止于如图7所示的出口47。进口46和出口47的用途将在下文进一步被描述。活塞主体40的上表面设置有周向凹部48,该周向凹部48成形为与如图6所示的柱塞22的下表面密封配合。
柱塞22包括在组装时彼此接合的下柱塞部50和上柱塞部51。需要时,通过利用卡配合构形或通过焊接或通过其它结合机构而实现永久的接合。下柱塞部50包括具有中心延伸孔54的大致为筒状的管部件。孔54的下端与入口53连通,该入口53被设置在柱塞22的下端面的中心处。下柱塞部50的下表面设置有周向脊52,该周向脊52成形为以密封的方式与活塞主体40的周向凹部48配合地接合。多个周向延伸的加强肋56从下柱塞部50的外表面的一部分向上延伸,如图2最清楚地所示。
上柱塞部51包括大致为柱形的部件,该部件在下端具有较窄插塞部57并且在上端具有较宽上部62。如图6所示,在组装时,插塞部57被接收在下柱塞部50的孔54内,以限定传送通道的下部55,传送通道的下部55是环形形状并且位于下柱塞部50的内表面与插塞部57的外表面之间。如图2以及图4所示,上部62设置有三个隔块58,这三个隔块58抵靠下柱塞部50的上缘。隔块58用作支座以产生三个径向口60,这些径向口60使传送通道的下部55与传送通道的上部59相连接,如图5所示,上部59形成于外柱塞部51的外表面与上壳体2的管状延伸部15的内表面之间。如图2所示,传送通道的该上部59包括三个轴向延伸路径,这些轴向延伸路径由在外柱塞部51的表面中形成的沟槽限定。每个沟槽从相应的口60向上延伸到柱塞部22的上端。如图2以及图4所示,在柱塞22的上端处设置涡旋腔构形61。
如图5所示,活塞泵4位于装置1内并且从鼻腔件11的远端朝向弹簧座部17延伸通过装置1。弹簧5被定位成在弹簧座部17的边界内从下壳体3的底座16向上延伸以支靠容器20的基座32并且从而被牢固地安置在柱延伸部33上方。因此,弹簧5用作偏压机构,以使容器20朝向出口10向上偏压。还应当注意的是,柱塞22在上壳体2的管状延伸部15中的接合使得防止柱塞22相对于上壳体2的相对向上轴向运动。类似地,活塞21与柱塞22之间的密封接合意味着,活塞21不能相对于上壳体2向上移动。
为了对装置1的致动进行控制,提供触发机构6。如图4最佳地所示,触发机构6包括由两个约束臂80互连的拇指垫81以及其它手指垫82。每个约束臂80均是拱形形状而具有弓形构造,其中每个约束臂80略微彼此远离地弓起。约束臂80由具有至少一定程度的弹性柔韧度的材料制成,该材料例如为聚丙烯、HDPE、ABS、聚酯或POM。优选地,拇指垫81、其它手指垫82以及约束臂80一体形成为单个模制件。如图4所示,在组装时,活塞泵4穿过约束臂80之间,并且具体地使得约束臂80的内表面接触容器20的主体30的外表面。此外,约束臂80的下边缘84抵靠容器20的凸缘34接合,如图3和5最佳地所示。优选地,约束臂80的尺寸和形状被选择成使得为适应容器的主体30的***该约束臂必须从它们的中立位置(neutralposition)彼此远离地略微挠曲,如图4所示。因此,约束臂80的弹性性质将趋于在容器20的主体30外部上提供小的向内力,从而改进约束臂80在凸缘34上的夹持并且防止意外释放。
在组装时,拇指垫81和其它手指垫82被定位在衬垫孔14中,当上壳体2和下壳体3被连接到一起时形成该衬垫孔14,如图1所示。此外,如图2最佳地所示,拇指垫81和其它手指垫82的下缘止靠在衬垫支承腹板19的上缘上并且抵靠该衬垫支承腹板19的上缘延伸。类似的支承腹板可作为上壳体2的一部分被设置用于拇指垫81和其它手指垫82的上缘。腹板19用于在致动时引导衬垫81和82的向内运动。
图5示出了被组装并且处于“待触发”构造的装置1,在该“待触发”构造中,装置1准备从泵腔35排出流体。在待触发构造中,活塞21在容器20中位于该容器20的上端,并且弹性凸起部41与密封凸起部42一起防止泵腔35中的任何流体达到活塞21的进口46。如上所述,约束臂80接合凸缘34,从而防止容器20朝向出口10向上移动。
泵腔35中的流体包括要被排出的单剂量流体。通常,流体包含药剂。药剂可作为溶液或溶剂或载体液体(例如,乙醇或异丙醇)中的粉末悬浮体被提供。
为了触发装置1,使用者将拇指垫81和其它手指垫82夹持在拇指和其它手指之间,并且将这些衬垫朝向彼此挤压。这使得约束臂80进一步远离彼此挠曲,从而使约束臂80的下缘84从凸缘34脱离。在该触发构造中,容器20的主体30在弹簧5的作用下朝向出口10向上移动。由于柱塞22和活塞21相对于上壳体2被轴向固定,因此容器20的主体30的向上运动具有试图减少泵腔35的容积的相应效果,这导致泵腔35内的流体被加压。泵腔35内的流体的压力的这种增加导致弹性凸起部41向上偏转,从而允许被加压的流体在弹性凸起部41与容器20的主体30的内表面之间通过。因此,被加压的流体能够达到活塞主体40的进口46。由于围绕活塞主体40的外周的其余部分的密封凸起部42的相对较硬的密封性能,因而流体仅能够通过定位有弹性凸起部41的100度的扇形。此外,由于密封环43的较高的密封性能,因此被加压的流体除了经由进口46之外不能完全溢出泵腔35。
因此,被加压的流体通过活塞主体40的进口46、沿横向导管44、沿轴向导管45流出出口47而离开泵腔35。由于活塞主体40的出口47与柱塞22的入口53对准,因此被加压的流体进入传送通道的下部55并且向上排出到下柱塞部50和上柱塞部51的插塞部57之间。之后,被加压的流体穿过口60而进入到传送通道的位于上部62和管状延伸部15之间的上部59内。最后,被加压的流体达到涡旋腔构形61,在涡旋腔构形61处,流体在以喷雾形式离开出口10之前被迫使形成旋转的涡旋图案。
如图所示,装置1是一次性装置,该一次性装置被设计成在单次排出操作之后被丢弃。有利地,该装置使用简单并且甚至能够由手动操作不太熟练的人员操作,因为所需要的仅是在拇指与其它手指之间的简单挤压钳形运动。此外,在操作之后,使用者不能接触到容器20,这防止了潜在误用或滥用容器20(例如,试图取回容器以接触柱塞)。用弹簧5来提供用于将流体从泵腔35排出的动力,从而提供了用于排出流体的一致的且与使用者无关的机构,这提供了喷出出口10的更均匀的喷雾几何形状。
图8示出了第二鼻腔装置1的包括上壳体2和下壳体3的壳体。与第一鼻腔装置相同的特征被赋予相同的附图标记并且将不再进一步详细地描述。读者参考上述说明来解释这些特征。还应理解的是,如本领域技术人员显而易见的,第一鼻腔装置和第二鼻腔装置的特征可以以任何组合形式来结合,因此在第一装置和第二装置中描述的特征的具体组合仅仅是示意性的。
与第一鼻腔装置相比,上壳体2的侧壁13设置有延长的裙部13’。裙部13’设置有一组上连接孔91以及一组下连接孔92。每组包括四个孔,在裙部13’的每个相对侧具有两个孔。
下壳体3设置有一组四个连接挡块93,在每个相对侧壁13上具有两个连接挡块。每个连接挡块93包括位于其上侧的倾斜面以及位于其下侧的平坦面,该平坦面大致垂直于裙部13’的表面。
在组装时,活塞泵4、弹簧5以及触发机构6被定位在壳体2、3内,并且下壳体3接合上壳体2,使得裙部13’被滑动地接收在下壳体3的侧壁13内。上壳体2和下壳体3被推动到一起,直到连接挡块93接合到下连接孔92中。在裙部13’沿连接凸块93的倾斜面经过并且位于该倾斜面上方时,通过使裙部13’向内挠曲来适应挡块93在孔91中的接合。
在该局部组装的构造中,上壳体2和下壳体3被连接到一起,活塞泵4和弹簧5在弹簧座部的向上延伸凸起部17内跨接在管状延伸部15与底座16之间。然而,与第一鼻腔装置相比,底座16与管状延伸部15的远端之间的更长距离导致弹簧5被相对更少地压缩且因此弹簧在容器20上施加减小的力。这在装置1的存储期间可有利地防止塑料部件蠕变(creep)以及防止活塞21在容器20内的向内蠕变。挡块93的平坦下表面防止上壳体2和下壳体3分离。
一旦需要使用该装置,则通过将上壳体2和下壳体3进一步推动到一起而能够完全组装该装置(例如,由制造商、终端使用者或药剂师组装),将上壳体2和下壳体3进一步推动到一起导致连接挡块93被向上推动成与上连接孔91接合。如前所述,该运动通过使裙部13’向内挠曲来适应。此时,弹簧5被完全压缩并且使该装置移动到“待触发”构造。
应当注意的是,触发机构6的约束臂80的存在在组装步骤期间防止容器20向上运动。
第二鼻腔装置的致动与上述的相同。
Claims (21)
1.一种用于排出流体的流体传送装置,所述流体传送装置包括:
壳体;
活塞泵;
偏压机构;以及
触发机构,
所述壳体包括用于排出所述流体的出口;
所述活塞泵包括限定用于存储所述流体的泵腔的外壳、能够相对于所述泵腔以滑动方式移动的活塞、活塞柱塞以及传送通道,所述传送通道用于将从所述泵腔排出的流体传送到所述壳体的所述出口;
所述偏压机构作用在所述活塞泵的所述外壳上,以朝向所述壳体的所述出口偏压所述外壳;
所述触发机构包括捕获构件和约束构件,所述捕获构件位于所述活塞泵的所述外壳上或被连接到所述外壳,所述约束构件能够由可手动致动的触发器移动;
所述触发机构借助所述可手动致动的触发器的操作而能够从待触发构造移动到触发构造;
其中,在所述待触发构造中,所述约束构件与所述捕获构件接合以防止所述外壳朝向所述壳体的所述出口移动,从而防止流体从所述泵腔排出;并且
在所述触发构造中,所述约束构件与所述捕获构件脱离接合,以使所述外壳能够在所述偏压机构的作用下朝向所述壳体的所述出口移动,从而将流体沿所述传送通道从所述泵腔排出所述壳体的所述出口之外。
2.根据权利要求1所述的流体传送装置,其中,所述约束构件是柔性的。
3.根据权利要求1或2所述的流体传送装置,其中,所述触发机构包括两个约束构件。
4.根据权利要求3所述的流体传送装置,其中,所述两个约束构件大致垂直于所述活塞泵的所述外壳的纵向轴线横穿所述壳体。
5.根据权利要求3或4所述的流体传送装置,其中,所述两个约束构件位于所述外壳的两侧。
6.根据权利要求3至5中任一项所述的流体传送装置,其中,所述两个约束构件包括一对臂,这一对臂在所述待触发构造中彼此向外弓起,并且这一对臂能够彼此远离地挠曲以使所述触发机构能够移动到所述触发构造。
7.根据前述权利要求中任一项所述的流体传送装置,其中,所述可手动致动的触发器包括拇指垫和其它手指垫,该拇指垫和该其它手指垫在使用时能够朝向彼此被挤压。
8.根据权利要求7所述的流体传送装置,其中,所述拇指垫和所述其它手指垫与所述约束构件一体形成。
9.根据引用权利要求6的权利要求7或8所述的流体传送装置,其中,所述拇指垫和所述其它手指垫与所述一对臂一体形成。
10.根据前述权利要求中任一项所述的流体传送装置,其中,所述捕获构件包括所述外壳的向外延伸的凸缘。
11.根据前述权利要求中任一项所述的流体传送装置,其中,所述活塞和所述活塞柱塞相对于所述壳体被固定。
12.根据前述权利要求中任一项所述的流体传送装置,其中,所述偏压机构包括在所述壳体和所述外壳之间作用的弹簧。
13.根据权利要求12所述的流体传送装置,其中,所述外壳包括远离所述壳体的所述出口延伸的支柱,所述支柱形成用于接收所述弹簧的一端的座部。
14.根据前述权利要求中任一项所述的流体传送装置,其中,所述活塞包括主体以及至少一个弹性凸起部,所述至少一个弹性凸起部在所述待触发构造中密封所述泵腔;在所述触发构造中,当所述外壳朝向所述壳体的所述出口移动时,由于所述泵腔内的压力因此增大,所述至少一个弹性凸起部能够偏转,从而适应所述流体从所述泵腔到所述传送通道内的排放。
15.根据权利要求14所述的流体传送装置,其中,所述至少一个弹性凸起部仅围绕所述活塞的外周的一部分延伸。
16.根据权利要求15所述的流体传送装置,其中,与所述至少一个弹性凸起部轴向对准的至少一个密封凸起部围绕所述活塞的所述外周的其余部分延伸。
17.根据前述权利要求中任一项所述的流体传送装置,其中,所述壳体包括上壳体和下壳体,所述上壳体限定所述出口,所述下壳体能够连接到所述上壳体以限定所述装置的用于容纳所述活塞泵和所述偏压机构的内部。
18.根据权利要求17所述的流体传送装置,其中,所述上壳体和所述下壳体包括连接机构,所述连接机构能够使所述上壳体和所述下壳体在局部组装的构造中被连接到一起,在所述局部组装的构造中,所述活塞泵和所述偏压机构跨接在所述上壳体和所述下壳体之间,其中所述偏压机构处于相对低压缩的第一状态;其中通过将所述上壳体和所述下壳体进一步移动到一起以将所述偏压机构压缩到相对高压缩的第二状态,所述连接机构还能够使所述上壳体和所述下壳体被完全组装。
19.根据权利要求18所述的流体传送装置,其中,所述连接机构包括位于所述上壳体和所述下壳体中的一个上的至少一个挡块以及位于所述上壳体和所述下壳体中的另一个上的两组孔,每组至少一个孔,其中,所述两组孔彼此轴向间隔开。
20.根据前述权利要求中任一项所述的流体传送装置,其中,所述装置是一次性装置。
21.根据前述权利要求中任一项所述的流体传送装置,所述流体传送装置结合被容纳在所述泵腔中的单剂量流体使用。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1104425.2 | 2011-03-16 | ||
GB1104425.2A GB2489216B (en) | 2011-03-16 | 2011-03-16 | Fluid delivery device |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102671269A true CN102671269A (zh) | 2012-09-19 |
CN102671269B CN102671269B (zh) | 2016-01-20 |
Family
ID=43981060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210033044.5A Active CN102671269B (zh) | 2011-03-16 | 2012-02-14 | 流体传送装置 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8590750B2 (zh) |
CN (1) | CN102671269B (zh) |
DE (1) | DE102012203866B4 (zh) |
FR (1) | FR2972650B1 (zh) |
GB (1) | GB2489216B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105407950A (zh) * | 2013-07-19 | 2016-03-16 | 和谐医疗有限公司 | 鼻腔、舌下或者眼睛用的流体输送装置 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201117518D0 (en) | 2011-10-11 | 2011-11-23 | Consort Medical Plc | Fluid delivery device |
EP3513783A1 (en) * | 2018-01-19 | 2019-07-24 | Welding GmbH & Co. KG | Container for pharmaceutical compositions comprising fentanyl |
US11027909B2 (en) * | 2018-08-15 | 2021-06-08 | Gpcp Ip Holdings Llc | Automated flowable material dispensers and related methods for dispensing flowable material |
WO2020144152A1 (en) * | 2019-01-08 | 2020-07-16 | Sanofi | Fluid dispensing device |
US11660407B2 (en) | 2020-05-14 | 2023-05-30 | Eli Lilly And Company | Nasal delivery device with safety rod |
USD1021066S1 (en) | 2022-03-03 | 2024-04-02 | Consort Medical Limited | Inhaler |
GB2617328A (en) * | 2022-03-31 | 2023-10-11 | Consort Medical Ltd | Fluid delivery device |
USD1021067S1 (en) | 2022-04-08 | 2024-04-02 | Consort Medical Limited | Inhaler |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1287890A (zh) * | 1999-09-15 | 2001-03-21 | 艾里希普费弗工程师有限公司 | 用于选择地雾化排放尤其是液体介质的设备 |
CN1355731A (zh) * | 1999-05-21 | 2002-06-26 | 瓦卢瓦股份有限公司 | 流体产品分配装置 |
EP1219356A2 (de) * | 1997-01-09 | 2002-07-03 | Ing. Erich Pfeiffer GmbH | Austragvorrichtung für fliessfähige Medien mittels einer Schubkolbenpumpe |
WO2004069664A2 (en) * | 2003-02-04 | 2004-08-19 | Bespak Plc | Closure member |
WO2010037759A1 (en) * | 2008-10-01 | 2010-04-08 | Shl Group Ab | Medicament delivery device powered by volute spring |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4079862A (en) * | 1975-02-03 | 1978-03-21 | Fegley Charles R | Chemical dispensing anti-burglary booby trap device |
US4394934A (en) * | 1979-07-02 | 1983-07-26 | Fegley Charles R | Fluid dispensing anti-burglar device |
SG45171A1 (en) * | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
IT1244803B (it) * | 1990-11-21 | 1994-09-05 | Promo Pack S A | Erogatore-spruzzatore monodose per la somministrazione endonasale di medicamenti liquidi. |
FR2682305B1 (fr) * | 1991-10-11 | 1993-12-24 | Valois | Dispositif de pulverisation ou de distribution d'une substance fluide, a actionnement mecanique. |
US5431155A (en) * | 1992-06-03 | 1995-07-11 | Elettro Plastica S.P.A. | Single-dose nasal dispenser for atomized liquid drugs |
AU729716B2 (en) * | 1997-05-23 | 2001-02-08 | Pa Knowledge Limited | Inhaler mechanism |
AU2214600A (en) * | 1998-12-29 | 2000-07-31 | Mckinley Medical, Lllp | Spring-powered infusion pump |
AU3421600A (en) * | 1999-02-14 | 2000-08-29 | Ing. Erich Pfeiffer Gmbh | Dispenser for flowable media |
GB2384527B (en) * | 2002-01-23 | 2004-07-14 | Bespak Plc | Dispensing device |
GB0204829D0 (en) * | 2002-03-01 | 2002-04-17 | Glaxo Group Ltd | A fluid dispensing device |
US7736712B2 (en) * | 2002-03-18 | 2010-06-15 | Consort Medical Plc | Seal material for a dispensing apparatus |
US7699052B2 (en) * | 2002-09-05 | 2010-04-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids, and the container cartridge |
GB2398503A (en) * | 2003-02-11 | 2004-08-25 | Bespak Plc | Inhaler with removable mouthpiece |
GB2406330B (en) * | 2003-09-29 | 2005-12-07 | Bespak Plc | A dispensing apparatus |
GB2414187B (en) * | 2004-05-21 | 2007-03-07 | Bespak Plc | Dispensing apparatus |
GB0610541D0 (en) * | 2006-05-26 | 2006-07-05 | Bespak Plc | Improvements in or relating to dispensing apparatus |
FR2908753B1 (fr) * | 2006-11-16 | 2011-11-11 | Becton Dickinson France | Dispositif pour delivrer automatiquement des doses successives de produit |
US20080210228A1 (en) * | 2007-03-02 | 2008-09-04 | Corbco, Inc. | Monodose nasal sprayer |
US8210167B2 (en) * | 2007-03-02 | 2012-07-03 | Corbco, Inc. | Manually operated monodose nasal sprayer |
DE102009017459B4 (de) * | 2009-04-02 | 2017-02-23 | Aptar Radolfzell Gmbh | Austragvorrichtung |
GB2471646B (en) * | 2009-05-11 | 2011-08-10 | Consort Medical Plc | Improvements in or relating to dispensing devices |
EP2275160A1 (de) * | 2009-07-13 | 2011-01-19 | Boehringer Ingelheim International Gmbh | Hochdruckkammer |
-
2011
- 2011-03-16 GB GB1104425.2A patent/GB2489216B/en active Active
-
2012
- 2012-01-26 US US13/358,988 patent/US8590750B2/en active Active
- 2012-02-02 FR FR1250970A patent/FR2972650B1/fr active Active
- 2012-02-14 CN CN201210033044.5A patent/CN102671269B/zh active Active
- 2012-03-13 DE DE102012203866A patent/DE102012203866B4/de active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1219356A2 (de) * | 1997-01-09 | 2002-07-03 | Ing. Erich Pfeiffer GmbH | Austragvorrichtung für fliessfähige Medien mittels einer Schubkolbenpumpe |
CN1355731A (zh) * | 1999-05-21 | 2002-06-26 | 瓦卢瓦股份有限公司 | 流体产品分配装置 |
CN1287890A (zh) * | 1999-09-15 | 2001-03-21 | 艾里希普费弗工程师有限公司 | 用于选择地雾化排放尤其是液体介质的设备 |
WO2004069664A2 (en) * | 2003-02-04 | 2004-08-19 | Bespak Plc | Closure member |
WO2010037759A1 (en) * | 2008-10-01 | 2010-04-08 | Shl Group Ab | Medicament delivery device powered by volute spring |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105407950A (zh) * | 2013-07-19 | 2016-03-16 | 和谐医疗有限公司 | 鼻腔、舌下或者眼睛用的流体输送装置 |
Also Published As
Publication number | Publication date |
---|---|
FR2972650A1 (fr) | 2012-09-21 |
US8590750B2 (en) | 2013-11-26 |
FR2972650B1 (fr) | 2017-07-21 |
DE102012203866B4 (de) | 2013-08-29 |
GB201104425D0 (en) | 2011-04-27 |
GB2489216A (en) | 2012-09-26 |
CN102671269B (zh) | 2016-01-20 |
DE102012203866A1 (de) | 2012-09-20 |
GB2489216B (en) | 2013-08-07 |
US20120234861A1 (en) | 2012-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102671269B (zh) | 流体传送装置 | |
EP2750802B1 (en) | Fluid delivery device | |
EP3021921B1 (en) | Fluid delivery device for nasal, sub-lingual or ophtalmic use | |
CN1787879B (zh) | 具有封堵器和端帽的流体分配装置 | |
CN104334219B (zh) | 多剂量注射器和方法 | |
US9096371B2 (en) | Metering valve and dispensing apparatus | |
EP1618049B1 (en) | Metering valve | |
CN103648559B (zh) | 模块化气体致动可缩回针头组件 | |
CN107530502A (zh) | 注射器***、活塞密封***、塞子***以及使用和组装方法 | |
EP2028132A1 (en) | Improvements in or relating to dispensing apparatus | |
JP4598527B2 (ja) | 一貫した供給を提供する定量吸入器のための計量弁 | |
TW202345926A (zh) | 流體輸送裝置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |