CN102671103A - 一种治疗内皮细胞功能障碍性血管病的中药组合物 - Google Patents
一种治疗内皮细胞功能障碍性血管病的中药组合物 Download PDFInfo
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Abstract
本发明涉及一种治疗内皮细胞功能障碍性血管病的中药组合物，由以下重量份的原药材制备而成，丹参30、瓜蒌10、薤白10、法半夏20、檀香10，砂仁10，苍术20、桃仁10、川芎10、红花10、益母草30、山楂20、白术10、茯苓10、甘草6，本发明对血管内皮细胞功能障碍性血管病有显著疗效。
Description
技术领域
本发明涉及一种治疗血管疾病的药物，具体涉及一种治疗内皮细胞功能障碍性血管病的中药组合物。
背景技术
血管内皮细胞裱衬在血管内壁，为血流提供光滑表面，起屏障作用，调节血管内外物质交换，是一个十分活跃的代谢及内分泌器官，可分泌多种血管活性物质，对于维持血管壁的张力、血管的舒张、血液的流动，促进管壁的炎症修复和抑制血管平滑肌细胞的增殖等具有重要作用。血管内皮细胞损伤可引起心、脑、肾及周围血管疾病，如动脉粥样硬化、高血压病、冠心病、糖尿病等，这些疾病严重威胁人类健康，可导致肢体坏疽、心肌梗死、心力衰竭、肾功能衰竭和脑卒中等。
中医中药治疗血管内皮细胞功能障碍一般是用活血化瘀，去瘀生新的药物达到治疗的效果，但是目前临床上缺少治疗这种疾病的疗效显著的中药。
发明内容
为了解决上述技术问题，本发明提供了一种治疗内皮细胞功能障碍性血管病的中药组合物。
本发明的技术方案如下：
一种治疗内皮细胞功能障碍性血管病的中药组合物，由以下重量份的原药材制备而成，丹参30、瓜蒌10、薤白10、法半夏20、檀香10，砂仁10，苍术20、 桃仁10、川芎10、红花10、益母草30、山楂20、白术10、茯苓10 、甘草6。
其制备方法如下：取以上各味，分别加入8倍，6倍量的水煎煮2次，每次2小时，过滤，浓缩，备用。
本中药组合物还可以运用现代制药技术，采用其他制备方法制备，并可加入药学上允许的辅料，制备成其他的剂型，如片剂，胶囊剂、丸剂及缓控释制剂等。
祖国传统医学理论中，血管内皮细胞功能障碍属于血瘀的范畴。本方中，丹参活血祛瘀，养血凉血、是为君药，瓜蒌、薤白有通脉散结、行气导滞和祛痰降浊之功效，是为臣药，法半夏、檀香、砂仁、苍术、桃仁、川芎、红花、益母草、山楂、白术、茯苓具有活血化瘀、软坚散结，降脂利水的功效，进一步增加丹参、瓜蒌和薤白的祛瘀散结的功效，同为佐药，使以甘草，调和诸药，共奏活血化瘀，祛瘀生新之作用，达到治疗血管内皮细胞功能障碍的作用。
临床资料
取在我院诊断为血管内皮细胞功能障碍患者200例，所选病例匀无有其他重大疾病，随机分为两组，每组100例，治疗组年龄在45-75之间，其中男59例，女41例，病程2年到15年，对照组年龄在47-76之间，其中男60例，女40例，病程1年半到16年，两组在性别、年龄、病程、血压、体重指数、吸烟、血脂异常危险因素方面无显著差异。
治疗方法
对照组给予阿托伐他汀20mg/d口服，疗程90d，治疗组给予本发明药物，服用方法为一重量份为一剂，一日一剂，分三次服用，疗程90d。
检测项目
1、血液流变特性检测
2、血管内皮舒张功能检测
试验结果
血液流变特性检测结果如下表：
血管内皮舒张功能检测结果如下表:
从以上两表检测结果可以看出，对照组治疗后超敏C-反应蛋白（hs-CRP） 和红细胞聚集指数明显下降(P<0.05)。治疗组治疗后，hs-CRP、高切全血表观黏度、低切全血表观黏度、血浆黏度和红细胞聚集指数较治疗前均有明显下降, 与对照组相比亦有明显改善(P<0.05)。对照组和治疗组治疗后内皮依赖性舒张功能（FMD）和非内皮依赖性舒张功能（NMD）均较治疗前明显改善(P<0.05)。治疗组治疗后FMD和NMD与对照组治疗后相比亦有明显改善(P<0.05)。从以上临床资料数据可以看出，本发明能改善内皮细胞功能障碍，具有治疗内皮细胞功能障碍性血管病的作用。
具体实施方式
下面结合实施例对本发明做进一步的说明。
实施例1
取丹参30g、瓜蒌10g、薤白10g、法半夏20g、檀香10g，砂仁10g，苍术20g、 桃仁10g、川芎10g、红花10g、益母草30g、山楂20g、白术10g、茯苓10g、甘草6g，分别加入8倍，6倍量的水煎煮2次，每次2小时，过滤，浓缩，备用。
Claims (1)
1.一种治疗内皮细胞功能障碍性血管病的中药组合物，其特征在于：由以下重量份的原药材制备而成，丹参30、瓜蒌10、薤白10、法半夏20、檀香10，砂仁10，苍术20、 桃仁10、川芎10、红花10、益母草30、山楂20、白术10、茯苓10 、甘草6。
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1334121A (zh) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | 一种通心络药物组合物及应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1334121A (zh) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | 一种通心络药物组合物及应用 |
Non-Patent Citations (4)
| Title |
|---|
| 《中华中医药学刊》 20090930 李联社 "补消三结合"治疗冠心病 1830-1832 1 第27卷, 第09期 * |
| 李眺 等: "活血化瘀法在血管内皮细胞功能障碍中的应用", 《中西医结合心脑血管病杂志》 * |
| 李联社: ""补消三结合"治疗冠心病", 《中华中医药学刊》 * |
| 黄宗明 等: "冠心病患者内皮细胞的损伤及其机制", 《徐州医学院学报》 * |
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