CN102669684A - Chinese medicinal extract and marine fish polypeptide composition for relieving visual fatigue - Google Patents
Chinese medicinal extract and marine fish polypeptide composition for relieving visual fatigue Download PDFInfo
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- CN102669684A CN102669684A CN201110061055XA CN201110061055A CN102669684A CN 102669684 A CN102669684 A CN 102669684A CN 201110061055X A CN201110061055X A CN 201110061055XA CN 201110061055 A CN201110061055 A CN 201110061055A CN 102669684 A CN102669684 A CN 102669684A
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Abstract
The invention discloses application of a composition in preparation of health-care food with an effect of relieving visual fatigue. According to the composition, Chinese medicinal materials such as figwort root, mulberry, lithospermum, trumpet creeper and marine fish polypeptide are used as raw materials and prepared into active ingredients; and the active ingredients and common medicinal accessories are prepared into an oral preparation.
Description
Technical field
The present invention relates to a kind of Chinese medical extract and marine fish peptide composition of alleviating asthenopia, belong to field of health care food.
Technical background
Visual fatigue is the subjective symptoms of human eye, and the syndrome that is interweaved of eye or the organic factor of whole body and mental element often is so claim kopiopia syndrome again; Current people's daily life often everyday in the face of computer, learning time increase, see the TV overlong time, use contact lenses or the like inducement often make much human often occur eyes dry and astringent, itch, symptom such as rubescent; Constitutional symptoms such as dizzy, nauseating, vomiting seriously can appear; And normal spiritedness is depressed, energy is not concentrated, failure of memory, insomnia etc., influences people's daily study, work and life.With regard to alleviating asthenopia or above-mentioned subjective symptoms; What the conscious custom of people was also often expected is that eyedrops is alleviated; Mostly product for relieving visual fatigue is that the external application eyedrops is main basically mostly at present; Mostly its composition is neurotrophic agents, sedative etc., such as panthenol, L-Aspartic acid potassium, vitamin B6, dipotassium glycyrrhizinate, naphazoline hydrochloride, chlorphenamine maleate, neostigmine methyl sulfate, sulfated compound chondroitin, and Chinese medicine pearl, borneol etc.
In recent years, people recognize that gradually the oral nutrient composition can alleviating asthenopia, comprise food, vitamin, health food etc., the health food of a lot of alleviating asthenopias progressively occurs; The composition of such health food is main for the composition of vitamins, plant extracts mostly; The health food that with marine resources is raw material is less, mainly is deep sea fish oil at present, utilizes it to be rich in nutritional labelings such as vitamin A and is efficacy factor.
The present invention is to be the marine fish polypeptide that extracts of raw material and the extract combination of Chinese medicine radix scrophulariae, mulberry fruit, Asian puccoon, Chinese trumpet creeper with the marine fish, plays the nutrition eye muscle and the effect of invigorating blood circulation, thereby reaches the alleviating asthenopia purpose.
Chinese patent publication number CN1583097A open " a kind of have the microcirculation of improvement and alleviate asthenopic health products " is a raw material with the fruit of glossy privet, the seed of Chinese dodder, chrysanthemum, plantain seed; Chinese invention patent publication number CN101856118A discloses " health food of a kind of alleviating asthenopia and preparation method thereof ", is made up of matrimony vine, chrysanthemum, cowberry, lutein, corn wet goods; Chinese patent publication number CN101450098A open " a kind of composition and method of making the same " with asthenopia releasing function,, lutein red by cowberry, vitamin E etc. are formed; Chinese invention patent publication number CN101642511A discloses " Chinese medicine composition of a kind of relieving visual fatigue and treating pseudomyopia and preparation method thereof ", is made up of matrimony vine, saline cistanche, chrysanthemum, the seed of Chinese dodder, the Radix Astragali, reticulate millettia, radix bupleuri, cassia seed etc.; Chinese patent publication number CN101095514A open " a kind of health food with asthenopia releasing function " is made up of cassia seed, cultivated land, Radix Angelicae Sinensis, chrysanthemum, the root of herbaceous peony, the root of Dahurain angelica, Ligusticum wallichii.Present a lot of bibliographical informations and invention relate to the alleviating asthenopia that Chinese medicine is a raw material, and it is main concentrating on the effect medicinal materials that clear liver and improve vision such as matrimony vine, chrysanthemum mostly, and with the composition of Chinese medicine and vitamin; The pathogenic characteristic of selecting for use with regard to Chinese medicine is many, and to select medicine with " clearing liver enriching yin " legislation be main.And the composition that forms with marine fish extraction polypeptide raw material and Chinese medicine extract does not appear in the newspapers.
Summary of the invention
The object of the invention provides a kind of health-care food composition; This health-care food composition is under traditional Chinese medical theory instructs, in conjunction with the marine fish polypeptide nutrition composition of modern biotechnology preparation, through the rational proportion of each composition; Synergy has clear and definite result of treatment to alleviating asthenopia.
Another one purpose of the present invention provides the preparation method of this health-care food composition.
Alleviating asthenopia health-care food composition of the present invention is to select Chinese medicine, marine fish polypeptides in combination to be prepared into active component, and wherein the radix scrophulariae flavor is sweet, bitter, salty, and cold nature is returned lung, stomach and kidney channel, effect clearing heat and cooling blood, purging intense heat enriching yin.The mulberry fruit flavor is sweet, sour, cold in nature, the thoughts of returning home, liver, kidney channel, and effect is the enriching yin of enriching blood, and promotes the production of body fluid and moisturizes.The Asian puccoon flavor is sweet, salty, cold in nature, and effect is a cooling and activating blood.The Chinese trumpet creeper flavor is sweet, sour, cold in nature, returns liver, pericardium channel, and effect is the row blood and dissolving stasis.Above-mentioned a few flavor Chinese medicine combination is played nourishing Yin and clearing heat, and the promoting blood circulation effect is share the marine fish polypeptide and is rich in the nutrition polypeptide, reaches the nutrition eye muscle jointly, and the promoting blood circulation effect plays function of relieving visual fatigue.
Characteristics of the present invention are: this invention health-care food composition combines theory of traditional Chinese medical science, is target to nutrition that improves eye muscle and microcirculation, is that therapeutic purpose selects the medicine prescription to reach alleviating asthenopia; Raw material is the polypeptide composition that common Chinese medicine material and marine fish are extracted, and safe ready can be grown and take.
The raw material consumption of preparation medicine activity component of the present invention is: radix scrophulariae 3-18 part, and mulberry fruit 5-18 part, Asian puccoon 3-12 part, Chinese trumpet creeper 1-9 part, marine fish polypeptide 1-15 part is formed.
Preferred for preparation active component raw material weight of the present invention consists of: 6 parts of radix scrophulariaes, 12 parts in mulberry fruit, 5 parts of Asian puccoons, 3 parts of Chinese trumpet creepers, 12 parts of marine fish polypeptide.
Medicine of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into conventional oral formulations, like tablet, capsule, oral liquid, electuary etc.
Take by weighing radix scrophulariae 3-18 part, mulberry fruit 5-18 part, Asian puccoon 3-12 part, Chinese trumpet creeper 1-9 part is subsequent use; Radix scrophulariae, mulberry fruit, Asian puccoon and Chinese trumpet creeper are mixed according to above-mentioned weight ratio, add 5-10 times of water gaging, preferred 8 times of amounts; Soak 1-2h, preferred 1.5h; Heating decocts, the back timing of boiling, and decocting time is 1-2h, preferred 1.5h filters; The dregs of a decoction add 3-7 times of water gaging again, preferred 5 times of water gagings, and heating decocts, the back timing of boiling, decocting time is 1-1.5h, and preferred 1h filters, and filtrating merges, and separates solid content.It is 1.08-1.12 that above-mentioned soup is concentrated into relative density,, advances spray dryer at preferred 1.10 o'clock; 130-150 ℃ of EAT control, preferred 140 ℃, leaving air temp 100-110 ℃; Preferred 105 ℃, 55-75 rev/min of atomizer rotating speed, preferred 60 rev/mins; Charging rate is 4-6ml/ minute, preferred 5ml/ minute, gets spray dried powder.Spray dried powder is pulverized, and sieves, and gets fine powder, and is subsequent use.Get the marine fish polypeptide powder and pulverize, sieve fine powder, with above-mentioned 4) spray dried powder evenly mix, subsequent use.The various conventional auxiliary material of needs when this fine powder can add the preparation different dosage form, the method for Chinese medicinal of routines such as lubricant, adhesive is prepared into the common Chinese medicine preparation formulation, like tablet, capsule, oral liquid, electuary etc.
Below in conjunction with embodiment the present invention is done further elaboration:
Embodiment 1 preparation tablets of the present invention (is example with ten times of material proportional quantities)
Take by weighing each raw material by following weight proportion: radix scrophulariae 60 grams, mulberry fruit 120 grams, Asian puccoon 50 grams, Chinese trumpet creeper 30 grams and 120 parts of marine fish polypeptide are subsequent use.
Radix scrophulariae, mulberry fruit, Asian puccoon and Chinese trumpet creeper are mixed by above-mentioned weight, add 8 times of water gagings and soak 1.5h, heating decocts, and the back timing of boiling decocts 1.5h, filters; The dregs of a decoction add 5 times of water gagings again, and heating decocts, and the back timing of boiling decocts 1h, filters, and filtrating merges, and separates solid content.It is 1.10 o'clock that above-mentioned soup is concentrated into relative density, advances spray dryer, 140 ℃ of EAT controls, and 105 ℃ of leaving air temps, 60 rev/mins of atomizer rotating speeds, charging rate is 5ml/ minute, gets spray dried powder; Spray dried powder is pulverized, and sieves, and gets fine powder, and is subsequent use.Other gets the marine fish polypeptide powder and pulverizes, sieve fine powder, evenly mix with spray dried powder, granulate drying, compressing tablet after adding auxiliary material.
The Ergonomy evaluation of experimental example 1 health food test-meal of the present invention
1. clinical data
73 healthy populations of voluntary participation, all participate in the simple eye or binocular vision of test-meal people through logarithmic visual acuity chart inspection＜5.0, computerized optometry behind the mydriasis fast, diopter between-0.5D～-3.0D, get rid of the organic illness of eye, amblyopia patient and hereditary myopia.Be divided into test-meal group and control group at random; Wherein 38 people are organized in treatment, control group 35 people, and two groups of examination trenchermans are at age, sex, myopic degree, and aspects such as eye subjective symptoms are there was no significant difference P＞0.05 relatively, has comparativity.
2. test-meal method
Test-meal group: oral present composition tablet, each 2, every day 2 times.Control group: OP (outward appearance, taste and treatment group preparation are roughly the same), dose is consistent with number of times and present composition tablet.Taking one month is a course of treatment, and experimenter and test-meal organizer are double blinding before finishing the course of treatment.
3. detection method
All experimenters carry out eyesight, slit-lamp, ophthalmoscope, routine blood test, routine urianlysis before taking.After taking the end course of treatment, repeat above-mentioned each item inspection.Before and after all experimenters take, respectively eye symptom is registered, with do not have (0 minute), light (1 minute), in (2 minutes), heavy (3 minutes) classification, and add up with integrated value.
4. criterion
Subjective symptoms is improved: before take (1) integration is arranged, taking the back integration is 0; (2) integration is all arranged before and after taking, but integration deducts and takes back integration >=1 before taking.Invalid: the identical person of integration before and after take (1); (2) take the back integration greater than integration person before taking.
Visual fatigue subjective symptoms decision method (sxemiquantitative integration method)
Annotate: " random thoughts " are meant 1-2 time/2 days; " time have " is meant 1-3 time/day; " often " be meant＞3 times/day
5. statistical analysis
Doing well,improving is added up with integration before and after taking, relatively the checking with T of two groups of sample averages.
6. result
After test-meal is taken, two groups of test-meal personnel subjective symptoms integration statistical results show: relatively have significant difference (P＜0.05) before and after the test-meal group is edible; There was no significant difference (P＞0.05) before and after control group is edible, back test-meal group is taken in test-meal and control group relatively has significant difference (P＜0.05).The result sees the following form 1.
Table 1 liang group clinical symptoms integration
※Has significant difference P＜0.05 before and after representing test-meal;
△Represent after the test-meal two groups significant difference P＜0.05 is relatively arranged.
Claims (4)
1. health-care food composition with remitting vision fatigue; The active component that it is characterized in that it mainly is to process oral formulations by the raw material of following weight portion: radix scrophulariae 3-18 part; Mulberry fruit 5-18 part, Asian puccoon 3-12 part, Chinese trumpet creeper 1-9 part, marine fish polypeptide 1-15 part is formed.
2. according to the health-care food composition of claim 1, wherein the consumption of each raw material is: 6 parts of radix scrophulariaes, 12 parts in mulberry fruit, 5 parts of Asian puccoons, 3 parts of Chinese trumpet creepers, 12 parts of compositions of marine fish polypeptide.
3. according to the health-care food composition of claim 1 or 2, said composition is prepared by the following step:
1) take by weighing radix scrophulariae 3-18 part, mulberry fruit 5-18 part, Asian puccoon 3-12 part, Chinese trumpet creeper 1-9 part is subsequent use;
2) radix scrophulariae, mulberry fruit, Asian puccoon and Chinese trumpet creeper are mixed according to above-mentioned weight ratio, add 5-10 times of water gaging, preferred 8 times of amounts; Soaked preferred 1.5h 1-2 hour; Heating decocts, the back timing of boiling, and decocting time is 1-2h, preferred 1.5h filters; The dregs of a decoction add 3-7 times of water gaging again, preferred 5 times of water gagings, and heating decocts, the back timing of boiling, decocting time is 1-1.5h, and preferred 1h filters, and filtrating merges, and separates solid content.
3) above-mentioned soup being concentrated into relative density is 1.08-1.12,, advances spray dryer at preferred 1.10 o'clock; 130-150 ℃ of EAT control, preferred 140 ℃, leaving air temp 100-110 ℃; Preferred 105 ℃, 55-75 rev/min of atomizer rotating speed, preferred 60 rev/mins; Charging rate is 4-6ml/ minute, preferred 5ml/ minute, gets spray dried powder.
4) spray dried powder is pulverized, and sieves, and gets fine powder, and is subsequent use.
5) get the marine fish polypeptide powder and pulverize, sieve fine powder, with above-mentioned 4) spray dried powder evenly mix, subsequent use.
4. can be prepared into conventional oral formulations according to the described health-care food composition of claim 1-3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110061055XA CN102669684A (en) | 2011-03-14 | 2011-03-14 | Chinese medicinal extract and marine fish polypeptide composition for relieving visual fatigue |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110061055XA CN102669684A (en) | 2011-03-14 | 2011-03-14 | Chinese medicinal extract and marine fish polypeptide composition for relieving visual fatigue |
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| CN201110061055XA Pending CN102669684A (en) | 2011-03-14 | 2011-03-14 | Chinese medicinal extract and marine fish polypeptide composition for relieving visual fatigue |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398252A (en) * | 2021-06-29 | 2021-09-17 | 李宇宙 | Eye drop rich in animal and plant active ingredients and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136442A (en) * | 1995-05-24 | 1996-11-27 | 程庆民 | Medicine for improving eyesight |
| JP2008297222A (en) * | 2007-05-29 | 2008-12-11 | Fuji Chem Ind Co Ltd | Composition for ameliorating accommodative dysfunction of eye |
| CN102669648A (en) * | 2011-03-09 | 2012-09-19 | 广州加原医药科技有限公司 | Health food for alleviating eye fatigue and preparation method thereof |
-
2011
- 2011-03-14 CN CN201110061055XA patent/CN102669684A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136442A (en) * | 1995-05-24 | 1996-11-27 | 程庆民 | Medicine for improving eyesight |
| JP2008297222A (en) * | 2007-05-29 | 2008-12-11 | Fuji Chem Ind Co Ltd | Composition for ameliorating accommodative dysfunction of eye |
| CN102669648A (en) * | 2011-03-09 | 2012-09-19 | 广州加原医药科技有限公司 | Health food for alleviating eye fatigue and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398252A (en) * | 2021-06-29 | 2021-09-17 | 李宇宙 | Eye drop rich in animal and plant active ingredients and preparation method thereof |
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Application publication date: 20120919 |
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