CN102648976A - Medicine for delaying chronic renal failure - Google Patents
Medicine for delaying chronic renal failure Download PDFInfo
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- CN102648976A CN102648976A CN2012101226788A CN201210122678A CN102648976A CN 102648976 A CN102648976 A CN 102648976A CN 2012101226788 A CN2012101226788 A CN 2012101226788A CN 201210122678 A CN201210122678 A CN 201210122678A CN 102648976 A CN102648976 A CN 102648976A
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Abstract
The invention discloses a medicine for delaying chronic renal failure. The medicine for delaying chronic renal failure is prepared from the following components in part by weight: 25-36 parts of radix astragali, 5-12 parts of tangerine peel, 10-15 parts of Rhizoma Pinelliae, 10-20 parts of Poria cocos, 10-15 parts of fructus amomi, 10-20 parts of Codonopsis pilosula, 3-20 parts of dried ginger, 7-23 parts of Coptis, 5-12 parts of cardamom seeds, 25-31 parts of red-rooted salvia, 10-17 parts of rhubarb, 16-28 parts of Rehmannia, 9-15 parts of yam, 10-15 parts of cornus, 2-10 parts of fried licorice, 9-15 parts of Poria cocos, 10-30 parts of dandelion and 6-15 parts of betel nut. Through a synergistic effect of various components in the compound prescription, the orally taken medicine for delaying progression of the chronic renal failure has the functions of tonifying the spleen, nourishing the kidney, harmonizing the stomach, removing the dampness, eliminating turbidity, detoxifying, benefiting Qi, activating blood circulation and the like and has obvious effects on deficiency of spleen and kidney, internal existence of wetness and turbidity, stasis of toxin and evils, obstruction of blood vessels and veins and the like caused by the chronic renal failure.
Description
Technical field
The present invention relates to the medicine of the depleted disease progression of a kind of delaying chronic kidney for oral administration
Background technology
Chronic renal failure (CRF) is the clinical syndrome by the complicacy that various CKDs continue progress, a large amount of nephronlosses of irreversibility due to increasing the weight of and various metabolism disorder are constituted.Main morphological change is the fibrosis of matter between glomerular sclerosis, renal tubules etc.It will carry out sexual development to end stage renal failure with friction speed.It mainly shows as the toxic metabolite retention, water, electrolyte, acid base imbalance, and the infringement of whole body multisystem.Chronic renal failure is the major disease of serious harm human health, and its sickness rate is sustainable growth trend in the world.Though the population of China prevalence does not have definite data statistics, it also increases year by year.According to Mount Huang meeting summary in 1992; Chronic renal failure is divided into: 1. renal function of compensatory phases 2. of renal function loses 4. uremia's phase of compensatory phases 3. renal failure stage (uremia's phase); Its Therapeutic Principle is: 1. the Preventing Countermeasures of morning, noon and afternoon CRF and measure: 1) in time, effectively control hypertension, 2) the property characteristic of ACEI and ARB, 3) strict blood sugar control; 4) control albuminuria, 5) dietetic therapy; 2.CRF nutrition treatment; 3. Drug therapy: 1) correct acidosis and correct metabolic acidosis, the control of b water sodium disorder, the treatment of c hyperpotassemia with water, electrolyte disturbance: a.2) hypertensive treatment, the 3) treatment of anemia and the application of erythropoietin, 4) hypocalcemia, 5) control infects 6) treatment of hyperlipemia, 7) oral adsorption method and catharsis therapy, 8) other; 4. uremia's alternative medicine: 1, hemodialysis, 2, peritoneal dialysis, 3, renal transplantation.In a word, to the various symptomatic treatments of chronic renal failure, to proceed to end stage renal failure be maximum target to delay it, to hope the life quality that improves the patient, reduces uremia's replacement therapy and reduce medical expense, and finally reduce its case fatality rate.
Summary of the invention
The object of the present invention is to provide a kind of chronic renal failure patient medicine that uses delaying chronic kidney hypofunction for oral administration that supplies.
The present invention is for realizing above-mentioned purpose, and the technical solution of employing is:
The medicine of delaying chronic kidney hypofunction is processed by the raw material of following weight parts: Radix Astragali 25-36, Pericarpium Citri Reticulatae 5-12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-15, Poria 10-20, Fructus Amomi 10-15, Radix Codonopsis 10-20, Rhizoma Zingiberis 3-20, Rhizoma Coptidis 7-23, KOUREN 5-12, Radix Salviae Miltiorrhizae 25-31, Radix Et Rhizoma Rhei 10-17, Radix Rehmanniae Preparata 16-28, Rhizoma Dioscoreae 9-15, Fructus Corni 10-15, Radix Glycyrrhizae Preparata 2-10, Poria 9-15, Herba Taraxaci 10-30, Semen Arecae 6-15.
Further; The medicine of delaying chronic kidney hypofunction is processed by the raw material of following weight parts: the Radix Astragali 30, Pericarpium Citri Reticulatae 10, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Poria 15, Fructus Amomi 13, Radix Codonopsis 15, Rhizoma Zingiberis 13, Rhizoma Coptidis 17, KOUREN 10, Radix Salviae Miltiorrhizae 27, Radix Et Rhizoma Rhei 14, Radix Rehmanniae Preparata 22, Rhizoma Dioscoreae 13, Fructus Corni 12, Radix Glycyrrhizae Preparata 7, Poria 12, Herba Taraxaci 20, Semen Arecae 12.
The present invention selects for use the Radix Astragali, Pericarpium Citri Reticulatae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Poria, Fructus Amomi, Radix Codonopsis, Rhizoma Zingiberis, Rhizoma Coptidis, KOUREN, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Radix Glycyrrhizae Preparata, Poria, Herba Taraxaci, Semen Arecae kinds of traditional Chinese medicines to process decoction or granule.Wherein: the Radix Astragali; Sweet tepor is returned the Liver and kidney warp, and nourishing YIN and supplementing blood, beneficial essence are filled out marrow; Be used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.Pericarpium Citri Reticulatae, the toil temperature, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm are used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Xin Wen, poisonous, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass are used for that abundant expectoration cough with asthma, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, phlegm retention vertigo and palpitation, breast gastral cavity painful abdominal mass are vexed, globus hystericus etc., are used for stopping nausea and vomiting by lowering the adverse flow of QI more.Poria, sweet light flat, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming are used for that edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool are had loose bowels, irritability, palpitation with fear insomnia.Fructus Amomi, Xin Wen, removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortively, be used for that turbid damp obstructing in middle-JIAO, wrist painful abdominal mass are not hungry, Deficiency and coldness of spleen and stomach, vomiting are had loose bowels, pregnancy reactions, frequent fetal movement.Radix Codonopsis, sweet little hardship is slightly cold, and moistening the lung and resolving phlegm, yin nourishing stomach function regulating, suppressing the hyperactive liver detoxifcation are used for cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, dizzy, the furunculosis skin infection of conjunctival congestion.Rhizoma Zingiberis, hot, warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, drying dampness to eliminate phlegm, and coldness and pain in the epigastrium, vomiting are had loose bowels, cold extremities faint pulse, phlegm retention are breathed with cough.Rhizoma Coptidis, bitter cold, heat clearing and damp drying, eliminating fire and detoxication are used for that damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood are told nosebleed, conjunctival congestion acid regurgitation, have a toothache, quenched one's thirst, the carbuncle furuncle.KOUREN, Xin Wen, the removing dampness painful abdominal mass that disappears, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.Radix Salviae Miltiorrhizae, hardship is slightly cold, and stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire are used for that menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection are swollen and ache, dysphoria and insomnia, hepatosplenomegaly, angina pectoris.Radix Et Rhizoma Rhei, bitter cold, the logical intestinal that expels the heat-evil, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Radix Rehmanniae Preparata, sweet tepor is returned the Liver and kidney warp, and nourishing YIN and supplementing blood, beneficial essence are filled out marrow, are used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.Rhizoma Dioscoreae, sweet flat, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Fructus Corni, sour and astringent tepor, liver and kidney tonifying, essence astringing and desertion stemming.Radix Glycyrrhizae Preparata, sweet flat, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, the multiple arteries and veins of invigorating the spleen and replenishing QI, weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
The compound granular of the depleted disease progression of this kind delaying chronic kidney for oral administration is through respectively forming the synergism of medicine in the compound recipe; Have strengthening spleen, tonifying kidney, stomach function regulating removing dampness, let out effects such as turbid toxin expelling, benefiting QI for activating blood circulation; To accumulateing in the deficiency of spleen and stomach of chronic renal failure, the turbid damp; The poison heresy is detained, and the obstructed grade of blood vessels has remarkable result.
The specific embodiment
Below in conjunction with embodiment the present invention is elaborated:
Embodiment 1
The medicine of delaying chronic kidney hypofunction is processed by the raw material of following weight parts: Radix Astragali 25-36, Pericarpium Citri Reticulatae 5-12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-15, Poria 10, Fructus Amomi 10, Radix Codonopsis 10, Rhizoma Zingiberis 3, Rhizoma Coptidis 7, KOUREN 5, Radix Salviae Miltiorrhizae 25, Radix Et Rhizoma Rhei 10, Radix Rehmanniae Preparata 16, Rhizoma Dioscoreae 9, Fructus Corni 10, Radix Glycyrrhizae Preparata 2, Poria 9, Herba Taraxaci 10, Semen Arecae 6.
Embodiment 2
The medicine of delaying chronic kidney hypofunction is processed by the raw material of following weight parts: the Radix Astragali 36, Pericarpium Citri Reticulatae 12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15, Poria 20, Fructus Amomi 15, Radix Codonopsis 20, Rhizoma Zingiberis 20, Rhizoma Coptidis 23, KOUREN 12, Radix Salviae Miltiorrhizae 31, Radix Et Rhizoma Rhei 17, Radix Rehmanniae Preparata 28, Rhizoma Dioscoreae 15, Fructus Corni 15, Radix Glycyrrhizae Preparata 10, Poria 15, Herba Taraxaci 30, Semen Arecae 15.
Embodiment 3
The medicine of delaying chronic kidney hypofunction is processed by the raw material of following weight parts: the Radix Astragali 30, Pericarpium Citri Reticulatae 10, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Poria 15, Fructus Amomi 13, Radix Codonopsis 15, Rhizoma Zingiberis 13, Rhizoma Coptidis 17, KOUREN 10, Radix Salviae Miltiorrhizae 27, Radix Et Rhizoma Rhei 14, Radix Rehmanniae Preparata 22, Rhizoma Dioscoreae 13, Fructus Corni 12, Radix Glycyrrhizae Preparata 7, Poria 12, Herba Taraxaci 20, Semen Arecae 12.
The manufacture method of the medicine of delaying chronic kidney hypofunction:
Get the Radix Astragali, Pericarpium Citri Reticulatae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Poria, Fructus Amomi, Radix Codonopsis, KOUREN, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Radix Glycyrrhizae Preparata, Poria, Herba Taraxaci, Semen Arecae, add 8 times of water gagings and decoct 2 times, each 1.5 hours, filter; Merging filtrate, being evaporated to relative density is 1.05～1.08 (60 ℃), puts coldly, adds ethanol and reaches 70% to containing alcohol amount; Placement is spent the night, and filters decompression recycling ethanol; And continue to be concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), drying under reduced pressure promptly gets.
Get Rhizoma Zingiberis, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei decoction piece, add 60% alcohol reflux 2 times, each 1.5 hours, filter, merging filtrate, decompression recycling ethanol, and continue to be concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), drying under reduced pressure promptly gets.
Get above-mentioned two parts of thick pastes, pulverize, cross 80 mesh sieves, add microcrystalline Cellulose, add starch, mix thoroughly, process granule with 90% ethanol to total amount, drying, compacting is in blocks, and the bag film-coat promptly gets granule medicament.
For showing the therapeutic effect of medicine of the present invention, carry out following comparative illustration:
1, clinical data
1. case choice criteria
Include standard in: (1) age was at 18～65 years old sex; (2) meet the chronic renal failure diagnostic criteria, it drafted standard in 1993 with reference to " CHINESE JOURNAL OF INTERNAL MEDICINE " editorial board nephropathy special interest group.1. chronic renal failure diagnostic criteria; 2. chronic renal failure clinical stages standard; 3. the tcm syndrome diagnosis is with reference to the standard of " the clinical research guideline of new Chinese medicine treatment chronic renal failure ".(3) differential diagnosis in tcm belongs in prescription with reference to " new Chinese medicine clinical research guideline " and renal failure recovering particles, deficiency of spleen and stomach that function cures mainly formulation, the turbid damp and accumulates, and malicious heresy is detained, the obstructed pattern of syndrome of blood vessels.
Exclusion standard: (1) is diagnosed as the acute renal failure patient; (2) peritoneal dialysis and hemodialysis patients; (3) gestation or preparation gestation and age of sucking are women; (3) merge to have the inclination, serious diseases such as brain, lung, liver, hemopoietic system, or the patient of wasting diseasess such as malignant tumor, active tuberculosis is arranged, hepatitis B inspection prompting e antigen positive person, or the renal transplantation latter; (4) psychotic, can not the partner.
2, physical data
The observation case is 2010 03 month and is in hospital and the out-patient to First People's Hospital, economic and technological development zone, 09 month Qingdao in 2011, complete case data is arranged, totally 130 examples.Adopt the completely random design, use the table of random number method, the sequencing of going to a doctor by the patient is divided into granule therapy group 80 examples at random with it; Man's 48 examples, women 32 examples, 18～65 years old age; On average (46.2 ± 12.8) year, the kidney health is injected matched group 50 examples, male 28 examples; Woman's 22 examples, 19～63 years old age, average (45.0 ± 14.6) year; Each organizes before patient's physical data and the treatment Alb, Hb, RBC, Scr, BUN level and 24hUpr through harmony relatively, and difference there are no significant meaning (P＞0.05) has comparability.
3, Therapeutic Method
All patients all adopt the high-quality low protein diet, combine diuresis according to the state of an illness, and controlling blood pressure is corrected acidosis, corrects anemia, corrects anti symptom treatment such as calcium and phosphorus metabolism disorder.On above-mentioned treatment basis, the treatment group gives the renal failure recovering particles, and warm water is taken after mixing it with water, every day 2 times.Matched group is treated with SHENKANG ZHUSHEYE, 5% glucose injection 250ml+ SHENKANG ZHUSHEYE 60ml intravenous drip, every day 1 time.2 months is a course of treatment.
4, observation index
Clinical symptoms and sign: anemia, weak, inappetence, dim complexion; Tongue fur and pulse condition; And limds edema etc.; Laboratory checking index as: the treatment before and after serum albumin (Alb), hemoglobin (Hb), RBC (RBC), serum creatinine (Scr), blood urea nitrogen (BUN) and twenty-four-hour urine protein quantification (24hUpr).
5, therapeutic evaluation
Treat chronic renal failure clinical research guideline and combine clinical experience to draft efficacy assessment standard with reference to new Chinese medicine in " new Chinese medicine clinical research guideline ".Clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and main physical and chemical index is normal; Produce effects: clinical symptoms, sign are obviously improved, and main physical and chemical index is normal basically; Effectively: clinical symptoms, sign all take a favorable turn, and main physical and chemical index is normal basically; Invalid: clinical symptoms, sign all do not have obvious improvement, even increase the weight of.
6, statistical method
Statistical procedures is used the SPSS13.0 statistical package; All continuous datas carry out the homogeneity of variance analysis earlier; Confirm the neat back employing of variance
expression; Relatively use the t check in the group, ranked data adopt Ridit to analyze, and P＜0.05 has been regarded as statistical significance.
Therapeutic evaluation
According to certain therapeutic evaluation standard, estimate curative effect and be: granule therapy group 0 example of fully recovering, produce effects 41 examples, effective 30 examples, invalid 9 examples; Matched group 0 example of fully recovering, produce effects 23 examples, effective 21 examples, invalid 6 examples.
Comparing difference does not have significance (P＞0.05) between two groups, sees table 1.
Table 1 liang group curative effect relatively
Annotate: compare P＞0.05 with matched group.
Table 2 is taken clinical drug symptom of the present invention, sign curative effect relatively
Annotate: there were significant differences for treatment group and matched group comparison total effective rate, P＜0.05.
Table 3 is taken Drug therapy of the present invention front and back serum creatinine, blood urea nitrogen and twenty-four-hour urine protein quantification and is changed relatively
Annotate: before two groups of treatments with treatment back serum creatinine, blood urea nitrogen and twenty-four-hour urine protein quantification relatively there were significant differences P＜0.01, two group between treatment back result relatively, difference does not have significance, P＞0.05.
Table 4 is taken Drug therapy of the present invention front and back albumin, hemoglobin and RBC and is changed relatively
Annotate: before two groups of treatments with treatment back serum creatinine, blood urea nitrogen and twenty-four-hour urine protein quantification relatively there were significant differences P＜0.01, two group between treatment back result relatively, difference does not have significance, P＞0.05.
About untoward reaction
After observation period endoparticle treatment group has some cases to take medicine reactions such as slight stomach discomfort, times of defecation increase are arranged, suitably reduce dosage or the back elimination mostly of taking medicine after meal, can proceed to observe; Kidney health matched group, idol has hypercalcemia to take place, suitably reduce the intake of vitamin D after, can eliminate symptom, proceed to observe.Groups of grains is 8.75% (7/80); Kidney health 8.00% (4/50), adverse reaction rate compares difference not statistically significant, P＞0.05 between each group.
In sum; More than use medicine of the present invention 80 routine chronic renal failure patients are done the treatment observation; Obtain significant curative effect, and Liver and kidney cardiac function and blood biochemical, defecation inspection before and after the treatment, obvious toxic-side effects all do not found; Drug administration safety of the present invention is described, to the effect of human non-toxic evil.
Claims (2)
1. the medicine of delaying chronic kidney hypofunction; It is characterized in that, process: Radix Astragali 25-36, Pericarpium Citri Reticulatae 5-12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-15, Poria 10-20, Fructus Amomi 10-15, Radix Codonopsis 10-20, Rhizoma Zingiberis 3-20, Rhizoma Coptidis 7-23, KOUREN 5-12, Radix Salviae Miltiorrhizae 25-31, Radix Et Rhizoma Rhei 10-17, Radix Rehmanniae Preparata 16-28, Rhizoma Dioscoreae 9-15, Fructus Corni 10-15, Radix Glycyrrhizae Preparata 2-10, Poria 9-15, Herba Taraxaci 10-30, Semen Arecae 6-15 by the raw material of following weight parts.
2. the medicine of delaying chronic kidney hypofunction according to claim 1; It is characterized in that, process: the Radix Astragali 30, Pericarpium Citri Reticulatae 10, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Poria 15, Fructus Amomi 13, Radix Codonopsis 15, Rhizoma Zingiberis 13, Rhizoma Coptidis 17, KOUREN 10, Radix Salviae Miltiorrhizae 27, Radix Et Rhizoma Rhei 14, Radix Rehmanniae Preparata 22, Rhizoma Dioscoreae 13, Fructus Corni 12, Radix Glycyrrhizae Preparata 7, Poria 12, Herba Taraxaci 20, Semen Arecae 12 by the raw material of following weight parts.
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Cited By (4)
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| CN103830466A (en) * | 2012-11-27 | 2014-06-04 | 包桂荣 | Medicine for treating early kidney failure |
| CN105614862A (en) * | 2016-01-22 | 2016-06-01 | 南京贝杉国际贸易有限公司 | Functional food capable of protecting renal function and delaying chronic renal failure process |
| CN107961364A (en) * | 2017-12-06 | 2018-04-27 | 南方医科大学深圳医院 | A kind of Chinese medicine composition for treating chronic renal failure |
| CN115779029A (en) * | 2022-12-23 | 2023-03-14 | 广州市番禺区中医院 | Preparation method of oral nephrosis traditional Chinese medicine decoction with low potassium content |
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| CN1814124A (en) * | 2005-08-29 | 2006-08-09 | 吴开敏 | Rehmannia-root preparation of nourishing Yin, supplementing kidney and Qi, activating blood circulation |
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| JP2002291439A (en) * | 2001-03-30 | 2002-10-08 | Kinjirushi Wasabi Kk | Food or preparation using spicy material as raw material |
| CN1814124A (en) * | 2005-08-29 | 2006-08-09 | 吴开敏 | Rehmannia-root preparation of nourishing Yin, supplementing kidney and Qi, activating blood circulation |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830466A (en) * | 2012-11-27 | 2014-06-04 | 包桂荣 | Medicine for treating early kidney failure |
| CN105614862A (en) * | 2016-01-22 | 2016-06-01 | 南京贝杉国际贸易有限公司 | Functional food capable of protecting renal function and delaying chronic renal failure process |
| CN107961364A (en) * | 2017-12-06 | 2018-04-27 | 南方医科大学深圳医院 | A kind of Chinese medicine composition for treating chronic renal failure |
| CN107961364B (en) * | 2017-12-06 | 2021-01-26 | 南方医科大学深圳医院 | Traditional Chinese medicine composition for treating chronic renal failure |
| CN115779029A (en) * | 2022-12-23 | 2023-03-14 | 广州市番禺区中医院 | Preparation method of oral nephrosis traditional Chinese medicine decoction with low potassium content |
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