CN102641712A - Novel reaction kettle for producing methylamino avermectin benzoate - Google Patents
Novel reaction kettle for producing methylamino avermectin benzoate Download PDFInfo
- Publication number
- CN102641712A CN102641712A CN2012100493315A CN201210049331A CN102641712A CN 102641712 A CN102641712 A CN 102641712A CN 2012100493315 A CN2012100493315 A CN 2012100493315A CN 201210049331 A CN201210049331 A CN 201210049331A CN 102641712 A CN102641712 A CN 102641712A
- Authority
- CN
- China
- Prior art keywords
- tube
- kettle
- finned tube
- refrigerant
- agitator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Physical Or Chemical Processes And Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a reaction kettle which comprises a vertical cylindrical kettle body, wherein the kettle body is provided with a kettle cover, a viewing mirror, a liquid longitudinal circulation system, a material port, a temperature probe and the like; a cooling jacket is arranged on the outer wall of the kettle body; a stirring device is arranged in the kettle body and penetrates through the kettle top to be connected with a power device; an air-pressure sealing device is arranged outside the rotatable connection part between the stirring device and the kettle top; the stirring is divided into three layers, wherein the three-vane propulsive stirring is performed at the bottom layer, and two-vane inclined-paddle type stirrers are arranged on the two layers above; annular pipes are arranged in the kettle body and connected by fin pipes; the kettle body, the kettle cover, the annular pipes and the fins are all made from 304 steel; and the outer layer is provided with the cooling jacket made from carbon steel. Compared with the existing reaction kettle, the reaction kettle disclosed by the invention has novel design, can mix the materials more sufficiently, improves the heat exchange efficiency, reduces the manufacturing cost, and particularly obviously improves the product conversion efficiency and reaction effect in the production of emamectin benzoate and improves the product quality.
Description
Technical field
The present invention relates to a kind of agitated reactor, belong to emamectin-benzoate and produce special-purpose agitated reactor.
Background technology
Emamectin-benzoate (to call first dimension salt in the following text) is a kind of new and effective semisynthetic antibiotics pesticide that begins to synthesize from fermented product AVM B1; It has ultra high efficiency; Low toxicity (preparation is near nontoxic), noresidue, the nuisanceless characteristics that wait biological pesticide; Relatively enlarged insecticidal spectrum with AVM, reduced toxicity people and animals.
The synthesis technique of first dimension salt mainly divided for five steps at present, was respectively C-5 protective reaction, C-4 oxidation reaction, C-4 imidization, C-4 reduction reaction, C-5 deprotection reaction.
Said novel reaction kettle is mainly used in C-5 protective reaction, C-4 oxidation reaction, the C-4 reduction reaction step that first dimension salt is produced; These reaction temperatures must strictly be controlled, otherwise cause accessory substance to increase, and product quality descends; The course of reaction very exothermic; So need at any time the heat that produces to be taken away, the inhomogeneous accessory substance that also can cause of the mixing of materials in the agitated reactor increases, and product yield and quality also can descend.Now comparatively common agitated reactor has only individual layer to stir and the chuck cooling structure, mainly takes to react in batches, reduce reaction speed in the production, the way in prolongation reaction time solves.Also do not have a kind of in the present existing equipment: can improve reaction speed, can shorten the reaction time again, make the agitated reactor that material can instantaneous abundant mixing, the material cyclicity is good, heat exchange area is big, heat exchange efficiency is high.
Summary of the invention
Technical problem to be solved by this invention is the shortcoming that overcomes prior art; The inventor furthers investigate first dimension salt oxidation reaction, design and provide a kind of make material can instantaneous abundant mixing, vertical good, the novel reaction kettle that heat exchange area is big, that heat exchange efficiency is high of circulation of material.
The agitated reactor that is used for emamectin-benzoate production of the present invention is achieved through following technical scheme:
A kind of agitated reactor that is used for emamectin-benzoate production,
Agitator is divided into three layers, and bottom is that three leaf propeller agitators, the top the 1st and the 2nd two-layer (being upper strata agitator and middle level agitator) are the oblique paddle agitator of two leaves; This agitated reactor exports on the jar at the jar base pressure and connects with pipeline, and is provided with vertical circulating pump 12, is used for improving vertical circulating effect, so that abundant mixing material.
Agitated reactor as previously discussed,
The kettle outer wall is provided with chuck 7, and kettle outer wall chuck bottom is provided with refrigerant inlet 12, and chuck top is provided with refrigerant exit 5; Still inner bottom part position is provided with down total endless tube 19, is provided with cooling finned tube refrigerant inlet 10 and cooling finned tube refrigerant exit 11 in the both sides of following total endless tube, and opposite ends is provided with shrouding 18 in following total endless tube; In perforate above total endless tube down, vertical welding finned tube, the other end of finned tube are used total endless tube 15 and are connected; Refrigerant flows into from cooling finned tube refrigerant inlet 10, owing to be provided with shrouding 18 in total endless tube down, refrigerant flow into total endless tube 15 from the finned tube of shrouding one side; Again from the finned tube of opposite side, total endless tube and the outflow of cooling finned tube refrigerant exit down; Above-mentioned finned tube comprises parent tube and fin two parts, is refrigerant in the parent tube, and the outside is a reaction mass.
The novel reaction kettle that is used for emamectin-benzoate production of the present invention has following beneficial effect compared with prior art:
1, compares with the common response still; The agitator of novel reaction kettle of the present invention is divided into three layers: bottom is three leaf propeller agitators, the last two-layer oblique paddle agitator of two leaves that is; Can make the instantaneous abundant mixing of material; Vertical circulating pump is installed on jar, has been increased the vertically effect of circulation of material again, these several measures make each material of this agitated reactor can access fabulous instantaneous sufficient mixing;
When 2, the kettle outer wall is provided with chuck, in still, also be provided with total endless tube and following total endless tube, connect with finned tube between endless tube, kettle outer wall chuck bottom is provided with refrigerant inlet 12, and chuck top is provided with refrigerant exit 5; Still inner bottom part position is provided with down total endless tube 19, is provided with cooling finned tube refrigerant inlet 10 and cooling finned tube refrigerant exit 11 in the both sides of following total endless tube, and opposite ends is provided with shrouding 18 in following total endless tube; In perforate above total endless tube down, vertical welding finned tube, the other end of finned tube are used total endless tube 15 and are connected; Refrigerant flows into from cooling finned tube refrigerant inlet 10, owing to be provided with shrouding 18 in total endless tube down, refrigerant flow into total endless tube 15 from the finned tube of shrouding one side; Again from the finned tube of opposite side, total endless tube and the outflow of cooling finned tube refrigerant exit down; Finned tube comprises parent tube and fin two parts, is refrigerant in the parent tube, and the outside is a reaction mass.
Such structure has the following advantages:
1) increase heat exchange area, for example common 2 tons of reacting kettle jacketing heat exchange areas are 6.85m
2, increasing after the finned tube, the agitated reactor heat exchange area reaches 16m
2More than;
2) because violent stirring produces foam, can reduce the coefficient of heat transfer of material in the still, through increasing the heat exchange effect that finned tube improves material in the still; Through the control of refrigerant flow rates different in chuck and the finned tube, can take away reaction more fast and produce heat, therefore improved heat exchange efficiency;
3, the application of new reaction still makes C-5 protective reaction, C-4 oxidation reaction practice thrift 17 hours reaction time, has improved product quality and product yield simultaneously;
4, the application of new reaction still, the C-4 reduction reaction is practiced thrift 8 hours reaction time, improves the quality of products simultaneously and product yield.
In a word, as stated:, make and when this first dimension salt is produced, compare with traditional agitated reactor owing to used this novel agitated reactor; Shortened the reaction time; Improve the thermal efficiency, reduced production cost, improved product quality and product yield; Therefore, have good economic benefits, social benefit and environmental benefit.
Description of drawings:
Fig. 1 is the overall structure sketch map of first dimension reactant salt still of the present invention;
Wherein: 1, agitator transmission device; 2, mechanical seal; 3, manhole; 4, cooling finned tube; 5, chuck refrigerant exit; 6, upper strata agitator; 7, chuck; 8, middle level agitator; 9 bottom agitators; 10, cooling finned tube refrigerant inlet; 11, cooling finned tube refrigerant exit; 12, chuck refrigerant inlet; 13, vertical circulating pump;
Fig. 2 is the endless tube of agitated reactor of the present invention and the structural representation of the annexation between the finned tube and endless tube and finned tube itself;
Wherein:
Fig. 2 .1 is: the front elevational schematic of the structure of the endless tube of agitated reactor of the present invention and the annexation between the finned tube and endless tube and finned tube itself;
Fig. 2 .2 is: the finned tube enlarged drawing;
Fig. 2 .3 is: the schematic top plan view of the structure of the endless tube of agitated reactor of the present invention and the annexation between the finned tube and endless tube and finned tube itself;
Wherein: 17.1 are: refrigerant, 17.2 is: material;
Wherein: 14, upper backup pad; 15, go up total endless tube; 16, tank body; 17, finned tube; 18, shrouding; 19, following total endless tube;
Fig. 3 is the structural representation of three leaf propeller agitators of the bottom of agitated reactor of the present invention;
Wherein:
Fig. 3 .1 is: the plan structure sketch map of three leaf propeller agitators of the bottom of agitated reactor of the present invention;
Fig. 3 .2 is: its A-A face cutaway view;
Fig. 3 .3 is: its B-B face cutaway view;
Wherein: 20, impeller boss; 21, fixed screw; 22, keyway; 23, blade;
Fig. 4 is the structural representation of the two last two-layer leaf inclined paddle type agitators of agitated reactor of the present invention;
Wherein:
Fig. 4 .1 is: the main TV structure sketch map of the two last two-layer leaf inclined paddle type agitators of agitated reactor of the present invention;
Fig. 4 .2 is: the plan structure sketch map of the two last two-layer leaf inclined paddle type agitators of agitated reactor of the present invention;
Fig. 4 .3 is: its left view.
Wherein: 24, blade; 25, impeller boss; 26, fixed screw holes; 27, keyway.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described further:
A kind of agitated reactor that is used for emamectin-benzoate production; It is the reactor of C-5 protective reaction, C-4 oxidation reaction, C-4 reduction reaction; Agitator is divided into three layers, and the bottom agitator is that three leaf propeller agitators, the top the 1st and the 2nd two-layer (being upper strata agitator and middle level agitator) are the oblique paddle agitator of two leaves; This agitated reactor exports on the jar at the jar base pressure and connects with pipeline, and is provided with vertical circulating pump, is used for improving vertical circulating effect, so that abundant mixing material.
Novel reaction kettle as previously discussed, the kettle outer wall is provided with chuck 7, and kettle outer wall chuck bottom is provided with refrigerant inlet 12, and chuck top is provided with refrigerant exit 5; Still inner bottom part position is provided with down total endless tube 19, is provided with cooling finned tube refrigerant inlet 10 and cooling finned tube refrigerant exit 11 in the both sides of following total endless tube, and opposite ends is provided with shrouding 18 in following total endless tube; In perforate above total endless tube down, vertical welding finned tube, the other end of finned tube are used total endless tube 15 and are connected; Refrigerant flows into from cooling finned tube refrigerant inlet 10, owing to be provided with shrouding 18 in total endless tube down, refrigerant flow into total endless tube 15 from the finned tube of shrouding one side; Again from the finned tube of opposite side, total endless tube and the outflow of cooling finned tube refrigerant exit down; Above-mentioned finned tube comprises parent tube and fin two parts, is refrigerant in the parent tube, and the outside is a reaction mass.
Novel reaction kettle as previously discussed, agitator transmission device power of motor 5.5KW; 16 groups of cooling finned tubes, finned tube parent tube external diameter 32mm, thickness 3.5mm, fin external diameter 50mm, fin pitch 6mm, fin thickness 1mm, every group leader 120mm goes up total endless tube, following total endless tube external diameter 76mm, source: self-control;
Upper strata agitator, middle level agitator agitator are two leaf inclined paddle type agitators, stir diameter 800mm, the wide 65mm of blade, the wide 18mm of key, set bolt M20; Source: Zhejiang Province Great Wall Reducer Co., Ltd;
The bottom agitator is three leaf propeller agitators, stirs diameter 650mm, the wide 18mm of key, set bolt M20 source: Zhejiang Province Great Wall Reducer Co., Ltd;
Agitated reactor dischargeable capacity 2m
3
Above accessory material is stainless steel 304;
Vertically circulating pump is: intet diameter 50mm, and the explosion-proof type magnetic drive pump of lift 25m, model is: 50CQ-25PB, source: ridge, Shen, Shanghai pump industry.
200 kilograms of AVM inventorys, with the result such as the table 1 of novel reaction kettle and common 2 tons of agitated reactor comparison production:
| ? | The common response still | Novel reaction kettle |
| The C-5 |
10 |
3 hours |
| The C-4 |
14 hours | 4 hours |
| Final products content | 69.93％ | 70.21％ |
| End product quality | 171.6 kilogram | 172.4 kilogram |
| First dimension salt yield | 85.8％ | 86.2％ |
Through the application of this agitated reactor, C-5 protective reaction, C-4 oxidation reaction are practiced thrift 17 hours reaction time, have improved product quality and product yield simultaneously.
The novel reactor of C-4 reduction reaction is used: agitator transmission device power of motor 5.5KW; 16 groups of cooling finned tubes, finned tube parent tube external diameter 38mm, thickness 3.5mm, fin external diameter 60mm, fin pitch 6mm, fin thickness 1mm, every group leader 120mm goes up total endless tube, following total endless tube external diameter 76mm, source: self-control;
Upper strata agitator, middle level agitator agitator are two leaf inclined paddle type agitators, stir diameter 800mm, the wide 65mm of blade, the wide 18mm of key, set bolt M20; Source: Zhejiang Province Great Wall Reducer Co., Ltd;
The bottom agitator is three leaf propeller agitators, stirs diameter 650mm, the wide 18mm of key, set bolt M20 source: Zhejiang Province Great Wall Reducer Co., Ltd;
Agitated reactor dischargeable capacity 2m
3
Above accessory material is stainless steel 304;
Vertically circulating pump is: intet diameter 50mm, and the explosion-proof type magnetic drive pump of lift 25m, model is: 50CQ-25PB, source: ridge, Shen, Shanghai pump industry.
200 kilograms of AVM inventorys, with the result such as the table 2 of novel reaction kettle and common 2 tons of agitated reactor comparison production:
| ? | The common response still | Novel reaction kettle |
| The C-4 |
12 hours | 4 hours |
| Final products content | 69.93％ | 70.21％ |
| End product quality | 171.6 kilogram | 172.4 kilogram |
| First dimension salt yield | 85.8％ | 86.2％ |
[0050]Through the application of this agitated reactor, the C-4 reduction reaction is practiced thrift 8 hours reaction time, has improved product quality and product yield simultaneously.
Be noted that above embodiment is a better example of the present invention; Be not used for limiting protection scope of the present invention; In the scope that does not break away from spirit of the present invention and design, those of ordinary skills can carry out various improvement or variation, still belong to protection scope of the present invention.
Claims (2)
1. one kind is used for the agitated reactor that emamectin-benzoate is produced,
It is characterized in that: agitator is divided into three layers, and the bottom agitator is that three leaf propeller agitators, upper strata agitator and middle level agitator are the oblique paddle agitator of two leaves; This agitated reactor exports on the jar at the jar base pressure and connects with pipeline, and is provided with vertical circulating pump (12).
2. agitated reactor as claimed in claim 1,
It is characterized in that: the kettle outer wall is provided with chuck (7), and kettle outer wall chuck bottom is provided with refrigerant inlet (12), and chuck top is provided with refrigerant exit (5); Still inner bottom part position is provided with down total endless tube (19), is provided with cooling finned tube refrigerant inlet (10) and cooling finned tube refrigerant exit (11) in the both sides of following total endless tube, and opposite ends is provided with shrouding (18) in following total endless tube; In perforate above total endless tube down; Vertical welding finned tube, the other end of finned tube are used total endless tube (15) and are connected, and refrigerant flows into from cooling finned tube refrigerant inlet (10); Owing to being provided with shrouding (18) in total endless tube down; Refrigerant flow into total endless tube (15) from the finned tube of shrouding (18) one sides, and from the finned tube of opposite side, total endless tube and the outflow of cooling finned tube refrigerant exit down, above-mentioned finned tube comprises parent tube and fin two parts again; Be refrigerant in the parent tube, the outside is a reaction mass.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100493315A CN102641712A (en) | 2012-02-29 | 2012-02-29 | Novel reaction kettle for producing methylamino avermectin benzoate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100493315A CN102641712A (en) | 2012-02-29 | 2012-02-29 | Novel reaction kettle for producing methylamino avermectin benzoate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102641712A true CN102641712A (en) | 2012-08-22 |
Family
ID=46654943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100493315A Pending CN102641712A (en) | 2012-02-29 | 2012-02-29 | Novel reaction kettle for producing methylamino avermectin benzoate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102641712A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223325A (en) * | 2013-05-07 | 2013-07-31 | 南通大力化工设备有限公司 | Mechanical agitator of reaction vessel |
| CN105461771A (en) * | 2015-12-30 | 2016-04-06 | 内蒙古嘉宝仕生物科技股份有限公司 | Emamectin benzoate preparation system |
| CN107490279A (en) * | 2017-08-17 | 2017-12-19 | 江南大学 | A kind of vacuum cyclone drying device for being used to dry heat sensitive material |
| CN114246834A (en) * | 2021-12-30 | 2022-03-29 | 宣城柏维力生物工程有限公司 | Melatonin orally disintegrating preparation for improving sleep and production process thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029143A (en) * | 1974-08-29 | 1977-06-14 | Hoechst Aktiengesellschaft | Polymerization reactor with gilled-tube radiator and axial agitator |
| CN1122609A (en) * | 1993-03-17 | 1996-05-15 | 利兰·T·泰勒 | Bottom feed-updraft gasification system |
| CN2774634Y (en) * | 2005-01-31 | 2006-04-26 | 西安航天华威化工生物工程有限公司 | Finned tube cooling type single bed layer tube type reactor |
| CN201002005Y (en) * | 2007-01-25 | 2008-01-09 | 杨爱民 | Multi-stage stirring spraying type esterification reaction still |
| CN201470387U (en) * | 2009-08-14 | 2010-05-19 | 南京科思化学有限公司 | Reactor |
-
2012
- 2012-02-29 CN CN2012100493315A patent/CN102641712A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029143A (en) * | 1974-08-29 | 1977-06-14 | Hoechst Aktiengesellschaft | Polymerization reactor with gilled-tube radiator and axial agitator |
| CN1122609A (en) * | 1993-03-17 | 1996-05-15 | 利兰·T·泰勒 | Bottom feed-updraft gasification system |
| CN2774634Y (en) * | 2005-01-31 | 2006-04-26 | 西安航天华威化工生物工程有限公司 | Finned tube cooling type single bed layer tube type reactor |
| CN201002005Y (en) * | 2007-01-25 | 2008-01-09 | 杨爱民 | Multi-stage stirring spraying type esterification reaction still |
| CN201470387U (en) * | 2009-08-14 | 2010-05-19 | 南京科思化学有限公司 | Reactor |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223325A (en) * | 2013-05-07 | 2013-07-31 | 南通大力化工设备有限公司 | Mechanical agitator of reaction vessel |
| CN105461771A (en) * | 2015-12-30 | 2016-04-06 | 内蒙古嘉宝仕生物科技股份有限公司 | Emamectin benzoate preparation system |
| CN105461771B (en) * | 2015-12-30 | 2019-02-12 | 内蒙古嘉宝仕生物科技股份有限公司 | Emamectin benzoate preparation system |
| CN107490279A (en) * | 2017-08-17 | 2017-12-19 | 江南大学 | A kind of vacuum cyclone drying device for being used to dry heat sensitive material |
| CN114246834A (en) * | 2021-12-30 | 2022-03-29 | 宣城柏维力生物工程有限公司 | Melatonin orally disintegrating preparation for improving sleep and production process thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20180119083A1 (en) | Airlift Reactor Assembly with Helical Sieve Plate | |
| CN102641712A (en) | Novel reaction kettle for producing methylamino avermectin benzoate | |
| CN201482481U (en) | Self-suction exhaust type stirring reactor | |
| CN201864727U (en) | Novel airlift internal circulation bioreactor | |
| CN203170309U (en) | Heating and cooling system of reaction kettle | |
| CN203816613U (en) | Reaction kettle of synthesizing ternary material precursor | |
| CN203018087U (en) | Reaction kettle | |
| CN106732290A (en) | A kind of reactor of continuous production nitromethane | |
| CN203736893U (en) | Crystallization kettle | |
| CN206333277U (en) | A kind of heat-exchanger rig for producing lactic acid bacteria goat milk beverage | |
| CN206566900U (en) | A kind of reactor of continuous production nitromethane | |
| CN104893959A (en) | Heat-exchange stirring device in biogas fermentation tank | |
| CN210545090U (en) | Large-volume ternary anode material precursor reaction kettle with high heat transfer efficiency | |
| CN206951179U (en) | A kind of reactor | |
| CN215464338U (en) | Organic synthesis reaction kettle with active cooling device | |
| CN216538380U (en) | Continuous ozone oxidation reactor | |
| CN202387465U (en) | Large adipic acid reactor | |
| CN210332669U (en) | Polymerization reaction kettle | |
| CN219342097U (en) | Axial flow type stirring fermenter | |
| CN207203946U (en) | A kind of horizontal agitated vessel | |
| CN2920389Y (en) | Polyisobutylene polymerization kettle | |
| CN212855586U (en) | Polymerization kettle for adhesive production | |
| CN210886012U (en) | Novel microbial fermentation tank | |
| CN214486524U (en) | High-efficient reation kettle is used in production of speaker glue | |
| CN214088468U (en) | Annular tube aerated yolk liquid fermentation tank |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120822 |