CN102638987A - 使用β3肾上腺素能受体激动剂和抗毒蕈碱药剂的组合疗法 - Google Patents
使用β3肾上腺素能受体激动剂和抗毒蕈碱药剂的组合疗法 Download PDFInfo
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- CN102638987A CN102638987A CN2010800550891A CN201080055089A CN102638987A CN 102638987 A CN102638987 A CN 102638987A CN 2010800550891 A CN2010800550891 A CN 2010800550891A CN 201080055089 A CN201080055089 A CN 201080055089A CN 102638987 A CN102638987 A CN 102638987A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (20)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24938609P | 2009-10-07 | 2009-10-07 | |
US61/249386 | 2009-10-07 | ||
PCT/US2010/050328 WO2011043942A1 (en) | 2009-10-07 | 2010-09-27 | Combination therapy using a beta 3 adrenergic receptor agonist and an antimuscarinic agent |
Publications (1)
Publication Number | Publication Date |
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CN102638987A true CN102638987A (zh) | 2012-08-15 |
Family
ID=43857059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2010800550891A Pending CN102638987A (zh) | 2009-10-07 | 2010-09-27 | 使用β3肾上腺素能受体激动剂和抗毒蕈碱药剂的组合疗法 |
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Country | Link |
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US (1) | US20120202819A1 (zh) |
EP (1) | EP2485595A4 (zh) |
JP (1) | JP5738871B2 (zh) |
KR (1) | KR20120093859A (zh) |
CN (1) | CN102638987A (zh) |
AU (1) | AU2010303811B2 (zh) |
BR (1) | BR112012007829A2 (zh) |
CA (1) | CA2774992A1 (zh) |
IL (1) | IL218756A0 (zh) |
IN (1) | IN2012DN02782A (zh) |
MX (1) | MX2012004134A (zh) |
NZ (1) | NZ599233A (zh) |
RU (1) | RU2012118668A (zh) |
WO (1) | WO2011043942A1 (zh) |
ZA (1) | ZA201202520B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111556753A (zh) * | 2017-12-21 | 2020-08-18 | 杏林制药株式会社 | 用于夜间尿频的治疗剂 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2011285928B9 (en) * | 2010-08-03 | 2018-08-02 | B3Ar Therapeutics, Inc. | Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder |
US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
KR20140044816A (ko) * | 2011-05-10 | 2014-04-15 | 테라비다, 인코포레이티드 | 과민성 방광을 치료하기 위한 솔리페나신과 타액 자극제의 복합제 |
US20150087832A1 (en) | 2011-10-27 | 2015-03-26 | Merck Sharp & Dohme, Corp. | Process for making beta 3 agonists and intermediates |
ES2584427T3 (es) | 2011-10-27 | 2016-09-27 | Merck Sharp & Dohme Corp. | Proceso para la preparación de agonistas beta 3 y productos intermedios |
CA2864173A1 (en) * | 2012-02-09 | 2013-08-15 | Altherx, Inc. | Combination of muscarinic receptor antagonists and beta-3 adrenoceptor agonists for treating overactive bladder |
US10287289B2 (en) | 2013-03-15 | 2019-05-14 | Merck Sharp & Dohme Corp. | Process for preparing beta 3 agonists and intermediates |
CA2919198A1 (en) * | 2013-07-23 | 2015-01-29 | Allergan, Inc. | Methods and compositions comprising desmopressin in combination with a beta-3-adrenergic receptor agonist |
KR20240010751A (ko) | 2014-11-20 | 2024-01-24 | 세레니티 파마슈티컬즈 엘엘씨 | 알파-아드레날린성 수용체 길항제와 조합된 데스모프레신을 포함하는 방법 및 조성물 |
EP3226849A4 (en) | 2014-12-03 | 2018-05-09 | Velicept Therapeutics, Inc. | Compositions and methods of using modified release solabegron for lower urinary tract symptoms |
WO2017015349A1 (en) * | 2015-07-20 | 2017-01-26 | Chase Pharmaceuticals Corporation | Muscarinic combination of a selective m2-antagonist and a peripheral non-selective antagonist for treating hypocholinergic disorders |
DK3365321T3 (da) | 2015-10-23 | 2024-01-15 | B3Ar Therapeutics Inc | Solabegron-zwitterion og anvendelser deraf |
WO2018039159A1 (en) * | 2016-08-22 | 2018-03-01 | Chase Pharmaceuticals Corporation | Muscarinic m2-antagonist combination |
CN115850286B (zh) * | 2022-12-05 | 2023-08-22 | 奥锐特药业(天津)有限公司 | 一种维贝格龙中间体及其制备方法 |
Citations (5)
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US6291491B1 (en) * | 1999-10-12 | 2001-09-18 | Merck & Co., Inc. | Amide derivatives as β 3 agonists |
US6413984B1 (en) * | 1999-02-02 | 2002-07-02 | Sanofi-Synthelabo | 8-(heterocyclylmethyl)quinoline derivatives for treating urinary incontinence |
US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
WO2008121268A1 (en) * | 2007-03-29 | 2008-10-09 | Merck & Co., Inc. | Combination therapy for the treatment-of lower urinary tract symptoms |
WO2009124166A1 (en) * | 2008-04-04 | 2009-10-08 | Merck & Co., Inc. | Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists |
Family Cites Families (3)
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WO2003024483A1 (fr) * | 2001-09-11 | 2003-03-27 | Fujisawa Pharmaceutical Co., Ltd. | Potentialisateur d'effets inhibiteurs sur la frequence des mictions et l'incontinence urinaire |
TWI295669B (en) * | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
EP1804778A1 (de) * | 2004-10-18 | 2007-07-11 | Boehringer Ingelheim International GmbH | Verwendung eines beta-3-agonisten zur behandlung von beschwerden der prostata und des unteren urogenitaltrakts |
-
2010
- 2010-09-27 EP EP10822429.6A patent/EP2485595A4/en not_active Withdrawn
- 2010-09-27 CN CN2010800550891A patent/CN102638987A/zh active Pending
- 2010-09-27 AU AU2010303811A patent/AU2010303811B2/en not_active Ceased
- 2010-09-27 CA CA2774992A patent/CA2774992A1/en not_active Abandoned
- 2010-09-27 NZ NZ599233A patent/NZ599233A/xx not_active IP Right Cessation
- 2010-09-27 WO PCT/US2010/050328 patent/WO2011043942A1/en active Application Filing
- 2010-09-27 KR KR1020127008961A patent/KR20120093859A/ko not_active Application Discontinuation
- 2010-09-27 IN IN2782DEN2012 patent/IN2012DN02782A/en unknown
- 2010-09-27 US US13/500,574 patent/US20120202819A1/en not_active Abandoned
- 2010-09-27 RU RU2012118668/13A patent/RU2012118668A/ru not_active Application Discontinuation
- 2010-09-27 JP JP2012533204A patent/JP5738871B2/ja active Active
- 2010-09-27 BR BR112012007829A patent/BR112012007829A2/pt not_active IP Right Cessation
- 2010-09-27 MX MX2012004134A patent/MX2012004134A/es not_active Application Discontinuation
-
2012
- 2012-03-20 IL IL218756A patent/IL218756A0/en unknown
- 2012-04-05 ZA ZA2012/02520A patent/ZA201202520B/en unknown
Patent Citations (5)
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US6413984B1 (en) * | 1999-02-02 | 2002-07-02 | Sanofi-Synthelabo | 8-(heterocyclylmethyl)quinoline derivatives for treating urinary incontinence |
US6291491B1 (en) * | 1999-10-12 | 2001-09-18 | Merck & Co., Inc. | Amide derivatives as β 3 agonists |
US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
WO2008121268A1 (en) * | 2007-03-29 | 2008-10-09 | Merck & Co., Inc. | Combination therapy for the treatment-of lower urinary tract symptoms |
WO2009124166A1 (en) * | 2008-04-04 | 2009-10-08 | Merck & Co., Inc. | Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists |
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AKIYOSHI OHTAKE ET AL: "Pharmacological Characterization of New Antimuscarinic Agent, Solifenacin Succinate, in Comparison with Other Antimuscarinic Agents", 《BIOL. PHARM. BULL》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111556753A (zh) * | 2017-12-21 | 2020-08-18 | 杏林制药株式会社 | 用于夜间尿频的治疗剂 |
Also Published As
Publication number | Publication date |
---|---|
MX2012004134A (es) | 2012-05-08 |
WO2011043942A1 (en) | 2011-04-14 |
BR112012007829A2 (pt) | 2015-09-22 |
IN2012DN02782A (zh) | 2015-09-18 |
AU2010303811A1 (en) | 2012-04-19 |
AU2010303811B2 (en) | 2013-01-24 |
RU2012118668A (ru) | 2013-11-20 |
EP2485595A4 (en) | 2014-03-12 |
IL218756A0 (en) | 2012-06-28 |
CA2774992A1 (en) | 2011-04-14 |
JP2013507363A (ja) | 2013-03-04 |
JP5738871B2 (ja) | 2015-06-24 |
NZ599233A (en) | 2013-04-26 |
EP2485595A1 (en) | 2012-08-15 |
ZA201202520B (en) | 2012-12-27 |
US20120202819A1 (en) | 2012-08-09 |
KR20120093859A (ko) | 2012-08-23 |
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