CN102631385A - Compound anti-aging quercetin nanoemulsion health care product - Google Patents
Compound anti-aging quercetin nanoemulsion health care product Download PDFInfo
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Abstract
The invention discloses a compound anti-aging quercetin nanoemulsion health care product which comprises the following raw materials in mass percent: 1-15% of quercetin, 15-40% of surfactant, 1-15% of cosurfactant, 5-25% of oil, 1-15% of celery aqueous extract, 1-15% of mushroom aqueous extract, and the balance of distilled water; and the sum of mass percents of the above raw materials is 100%. The nanoemulsion is small in emulsion droplet, uniform in distribution, low in viscosity and good in liquidity. The compound anti-aging health care product takes fat soluble natural product quercetin with an efficient anti-aging effect as a main component, takes the celery aqueous extract and the mushroom aqueous extract as auxiliary components, has effects of keeping skin moisture, adjusting slumber, delaying senescence and adjusting immunologic function and has certain health care effect on diseases such as hypertension, hyperlipemia, hyperglycemia, heart disease and the like.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of novel form of antisenescence health product Quercetin, particularly a kind of compound recipe quercetin nano breast antisenescence health product.
Background technology
Quercetin (Quercetin) has another name called quercetin, and Quercetin is dissolved in glacial acetic acid, and it is yellow, water-soluble hardly that alkaline aqueous solution is, and the alcoholic solution flavor is very bitter.
Quercetin can significantly suppress the effect of carcinogenic promoting agent, the growth that suppresses stripped malignant cell, inhibition ehrlich ascites cell DNA, RNA and protein synthesis.
Cortex querci dentatae have the release action of anticoagulant and 5-hydroxy tryptamine (5-HT).Quercetin all has obvious inhibitory action to the inductive platelet aggregation of ADP, thrombin and platelet activating factor (PAF), and wherein the inhibitory action to PAF is the strongest, and Quercetin is the obviously inductive rabbit platelet 3H-5-HT release of Trombin inhibiting also.
Result of study shows that receiving significantly increases according to peroxidating material MDA content in the rat liver, and the scientific research personnel thinks that the fatty acid composition that it maybe the radical pair membrane lipid causes damage to cause.And take in the activity that Quercetin can improve the content and the antioxidant reductase of liver antioxidant, and quicken the decomposition of hydrogen peroxide, the infiltration that alleviates inflammatory cell helps antioxidation and protection hepatocyte.Simultaneously, Quercetin can significantly strengthen the rate of increase of irradiation group rat lymphocyte, and significantly increases the percentage rate of immune accessory cell, immunologic cytotoxicity cell.This shows that Quercetin has mitigation to receiving according to the response to oxidative stress of rat body really.
Quercetin antioxidation, defying age are effective, but because fat-soluble defective itself causes the effect of Quercetin fully to be utilized by performance, make Quercetin to be fully used.
Summary of the invention
To the shortcomings and deficiencies that exist in the prior art, the object of the present invention is to provide a kind of being evenly distributed, good stability, the compound recipe quercetin nano breast antisenescence health product that permeability is high, dissolubility is good, bioavailability is high.
The technical scheme that realizes the foregoing invention purpose is: a kind of compound recipe quercetin nano breast antisenescence health product, and the particle diameter that it is characterized in that this medicine is between 67.1～92.4nm, and mean diameter is 78.4nm, and its raw material and mass percent thereof are:
Quercetin 1%～15%
Herba Apii graveolentis water extract 1%～15%
All the other compositions are distilled water, and the mass percent sum of above-mentioned raw materials is 100%.
The selected Herba Apii graveolentis of the present invention belongs to samphire.Two kinds of Herba Oenanthes Javanicae, Herba Apii graveolentis are arranged, and function is close, and medicinal is good with Herba Apii graveolentis.Herba Apii graveolentis fragrance is denseer, has another name called " Apium graveolens ", also claims " medicine celery ".Herba Apii graveolentis is a high fiber food, and it produces the material of a kind of lignin or enteral fat through the enteral Digestion, and this type material is a kind of antioxidant, and is all very useful to prophylaxis of hypertension, arteriosclerosis etc., and the auxiliary treatment effect is arranged.
Meridian distribution of property and flavor: cool in nature, sweet in the mouth is hot, and is nontoxic; Go into lung, stomach, Liver Channel.Effect cures mainly: clearing heat and relieving fidgetness, suppressing the hyperactive liver, inducing diuresis to remove edema, cooling blood for hemostasis.Cure mainly hypertension, headache, dizziness, the sudden high fever excessive thirst, jaundice, edema, urine heat is puckery unfavorable, menoxenia, leucorrhea with red and white discharge. scrofula. diseases such as mumps.
Effect: 1. suppressing the hyperactive liver blood pressure lowering: Herba Apii graveolentis contains tart antihypertensive compositions, and rabbit, dog intravenous injection are had obvious hypotensive effect; The blood vessel perfusion can distend the blood vessels; Use the aortic arch perfusion method, it can resist nicotine, the mountain obstructs the booster reaction that theophylline causes, and can cause blood pressure lowering.Clinical all effective for constitutional, gestational and climacteric hypertension.2. tranquillizing and allaying excitement: isolated a kind of alkaline components from seed of Herba Apii graveolentis, animal there is sedation, people's physical ability is played stable effect; Herba Apii graveolentis is sweet or apigenin is oral can be excited to the mice that anti-***e causes, helps stable emotion, eliminates irritated.3. inducing diuresis to remove edema: Herba Apii graveolentis contains the diuresis effective ingredient, eliminates water-sodium retention in the body, inducing diuresis to remove edema.Reach 85.7% with Herba Apii graveolentis decocting effective percentage clinically, can treat chyluria.4.: the cancer-resisting Herba Apii graveolentis is a high fiber food, and it produces the material of a kind of lignin or enteral fat through the enteral Digestion, and this type material is a kind of antioxidant, can suppress the carcinogen that intestinal bacterium produces during high concentration.It can also accelerate the duration of runs of feces at enteral, reduces carcinogen and reaches the purpose of preventing colon cancer with contacting of mucous membrane of colon.5. tonify deficiency nourishes blood: the Herba Apii graveolentis iron-holder is higher, can replenish the loss of women's menses, food can avoid palor, drying, lusterless complexion, and can make lustrous eyes, hair is shiny black.6. heat-clearing and toxic substances removing: dry in autumn, people often feel that dry mouth and tougue asthma is vexed, uncomfortable, often eat a little Herba Apii graveolentis and help heat-clearing and toxic substances removing, prevent or cure a disease and keep fit.Liver-fire is prosperous excessively, and the people of pachylosis and frequent insomnia, headache can suitably eat more.
The selected mushroom of the present invention (mushrooms), the Eumycota Agaricus edibilis, mushroom is rich in 18 seed amino acids, multivitamin and mineral such as abundant calcium, ferrum, rich nutrient contents such as inanimate matter, vitamin, protein, plant cellulose, heat is low.
Pharmacology: 1. antibacterial action: the culture fluid of mushroom (cultivating 22 days for 28～30 ℃) can suppress staphylococcus aureus, Bacillus typhi and escherichia coli, and this culture fluid is nontoxic to Cavia porcellus, and human oral also has no side effect for 250 milliliters.The squeezing juice of congener AgaricusnebularisBatsch. still can suppress mycobacterium and tubercule bacillus.2. human body immunity improving power: the effective ingredient of mushroom can strengthen the T lymphocyte function, thereby improves the immunologic function that body is resisted various diseases.3. analgesia, calmness: certain institute of Brazil extracts a kind of substance A ct-2 from mushroom, tool analgesia, calm effect, its analgesic effect can replace morphine.4. relieving cough and resolving phlegm: said mushroom extract is used for zoopery, finds the effect that it has tangible antitussive, desaturation sputum.5. anticancer: it is 288 HHT higher high tensile cancer-resisting substance that the Japanology personnel analyze a kind of molecular weight in the effective ingredient mushroom, growth that can anticancer, and its effect is stronger 1000 times than the cancer-resisting substance in the green tea.Also contain a kind of toxalbumin in the mushroom, can stop the albumen of cancerous cell synthetic effectively.6. catharsis and toxin expelling: contained human body is difficult to crude fibre, half crude fibre and the lignin of digestion in the mushroom, can keep enteral moisture, and absorbs remaining cholesterol, sugar, it is excreted, to prevent constipation, intestinal cancer, arteriosclerosis.Diabetes etc. are all very favourable.
The surfactant that the present invention selects for use be in polyoxyl 40 hydrogenated castor oil, castor oil polyoxyethylene ether 40, Tween 80 or the poloxamer 188 any one or with the mixture of span80, these surfactants are to human body low toxicity, safe, non-stimulated.
The oil that the oil that the present invention selects for use is is any one or a few the mixture in soybean oil, Oleum Brassicae campestris, isopropyl myristate, ethyl acetate, ethyl oleate or the oleic acid, and is safe, nontoxic.
The cosurfactant that the present invention selects for use is a dehydrated alcohol, 1, the mixture of any one or a few in 2-propylene glycol, PEG400 or the glycerin.
The administration of compound recipe quercetin nano of the present invention breast administered through oral has improved the dissolubility of medicine greatly, reduces medicine first pass effect in vivo, promotes the gastrointestinal absorption of medicine.Quercetin utmost point indissoluble in water is separated; Make the transhipment and the absorption of medicine become difficult; Nano-emulsion substrate is that Quercetin provides good dissolving environment, and through compound recipe Herba Apii graveolentis water extract and mushroom water extract, makes that antioxidation, the defying age effect of this compound nanometer emulsion are better remarkable and lasting.Can absorb the barrier when overcoming first pass effect and molecule when oral through lymph through gastrointestinal tract.
Compound recipe quercetin nano breast of the present invention compared with prior art has the following advantages:
1. the diameter of aspirin particle of Quercetin defying age nano-emulsion of the present invention is between 67.1～92.4nm; Mean diameter is 78.4nm; Be that Quercetin is dissolved in the oil phase, add surfactant and cosurfactant), be titrated to even, transparent nano-emulsion system with distilled water.The compound recipe quercetin nano breast that forms contains Quercetin and reaches more than 5.8%.
2. Quercetin resisting hypertension nano-emulsion of the present invention is evenly distributed, and transparent, the good stability of system has lower surface tension, and water-in-oil type nanoemulsion has good flowability.
3. engulfed by reticuloendothelial cell rapidly after the Quercetin resisting hypertension nano-emulsion of the present invention administration, make the rapid onset of medicine, and keep constant blood drug level and pharmacodynamics effect, improve bioavailability of medicament, reduce amount of drug and access times.
4. this compound nanometer emulsion makes that through adding Herba Apii graveolentis water extract and mushroom water extract the defying age effect of this compound nanometer emulsion is better remarkable and lasting.
5. Quercetin resisting hypertension nano-emulsion method for preparing of the present invention is simple, efficacy stability, and living power consumption is low.
6. the present invention processes and can be made into oral liquid after the nanometer and directly take, also can seal or through processing such as lyophilized powder technology through capsule.
Test Example 1 compound recipe quercetin nano breast antisenescence health product size of the present invention is analyzed.
Description of drawings
Fig. 1 is compound recipe quercetin nano breast electromicroscopic photograph of the present invention.
Fig. 2 is compound recipe quercetin nano breast granularmetric analysis curve chart of the present invention.
The specific embodiment
The inventor provides concrete method for preparing embodiment and uses the test of pesticide effectiveness to further specify the effect of medicine of the present invention.
Test Example 1 compound recipe quercetin nano breast antisenescence health product of the present invention stability analysis
The present invention detects (Fig. 1) through transmission electron microscope, and drop type of being is spherical, good dispersion, no adhesion.Detect (Fig. 2) its diameter Distribution between 67.1～92.4nm through the Ma Erwen Particle Size Analyzer, mean diameter is 78.4nm.
Whether through the stability that compound recipe quercetin nano breast antisenescence health product of the present invention is observed in following centrifugal test, light stability test, temperature stability test etc., observing the present invention has layering, muddiness or crystal wild effect such as to separate out.
1. high speed centrifugation test
Get the newborn antisenescence health product of the compound recipe quercetin nano of the present invention for preparing in right amount in centrifuge tube; With centrifugal 15 min of the rotating speed of 10 000r/min; After the centrifugal test; Compound recipe quercetin nano of the present invention breast antisenescence health product still keeps the clear before centrifugal, wild effect such as do not see that layering, muddiness or crystal are separated out.
2. light stability test
The compound recipe quercetin nano for preparing in right amount breast antisenescence health product is packed in transparent good colourless, the transparent vial, and sealing is positioned over 10d under the normal illumination condition, respectively at 1d, 2d, 4d, 6d, 8d, the 10d observation of taking a sample.The result shows that the every duplicate samples of compound recipe quercetin nano breast antisenescence health product all keeps clear, wild effect such as do not see that layering, muddiness or crystal are separated out.
3. temperature stability test
The compound recipe quercetin nano for preparing in right amount breast antisenescence health product is packed in transparent good colourless, the Clear glass bottles and jars, sealing, be positioned over 4 ℃, room temperature (25 ℃) with 40 ℃ three in keep sample under the temperature conditions and investigate each 30d, every at a distance from 5d sampling observation.The result shows, compound recipe quercetin nano breast antisenescence health product all keeps clear under these three kinds of temperature conditions, wild effect such as do not see that layering, muddiness or crystal are separated out.
4. long-term stable experiment
3 batches of nano-emulsions are sealed in the Brown Glass Brown glass bottles and jars only; Placed (25 ± 2) ℃, relative humidity (60 ± 5) % condition following 12 months; Respectively at 0,3,6,9 and time sampling in 12 months; Investigate the character and the changes of contents of nano-emulsion, and the list of references statistical analysis technique, the effect duration of calculating compound recipe quercetin nano breast antisenescence health product.Result of the test is illustrated under the long term test condition, and the outward appearance of compound recipe quercetin nano breast antisenescence health product keeps clear and bright, homogeneous always, does not see phenomenons such as layering, complexion changed, flocculation and breakdown of emulsion; Quercetin content in the system prolongs in time and reduces gradually, the equation of linear regression that its content-time changing curve provides, and the effect duration that calculates compound recipe quercetin nano breast antisenescence health product is 31.22 months.
Test Example 2 toxicity tests and conclusion:
Product of the present invention is in strict accordance with having carried out acute toxicity test by " toxicological evaluation of food safety procedure and method "; Genetic toxicity test; Comprise Ames test, mouse bone marrow cells micronucleus test, mouse sperm deformity test, mice guilt ball chromosomal aberration test and mice 30d feeding trial, result of the test is following.
These article are to chmice acute toxicity test conclusion: observe a week continuously after the administration, 60 mices do not have obvious adverse reaction and death.These article are 180g/kg to the dosis tolerata of mouse stomach, are equivalent to 1800 times of clinical consumption.Set up standard separately according to acute toxicity, these article belong to innocuous substance.
The result of genetic toxicity tests such as the Salmonella reversion test of product of the present invention, mouse sperm deformity test and testicular chromosome aberration test is all negative.
The result that rat 30d feeds product of the present invention shows: each experimental group animal growth is good in experimental period; Indexs such as body weight, food ration, routine blood test, blood biochemistry, organ coefficient are all in normal range; Histopathologic examination is no abnormality seen also, and these article free of toxic effects is described.
These article long term toxicity test conclusion: this medicine of various dose was not seen the rat untoward reaction in three months at continuous gastric infusion; All in normal range, its main organs of pathologic finding and target organ do not see that all the toxic pathology that this guiding drug rises changes to each item inspection index.
Test Example 3 drug efficacy study project and conclusions:
1. female mice genitals result of the test shows: the 1. mice of injection of d-galactose and compared with normal, its ovary and uterus SOD, GSH-Px and total protein content and serum estradiol content significantly descend, MDA content significantly raise (P < 0.01).2. after taking these article, mouse ovarian and uterus SOD, GSH-Px and total protein content raise respectively (P 0.01, P 0.05), MDA content significantly descend (P < 0.01).3. after taking these article, the mice serum estradiol content promotes, and is respectively (6.68 ± 0.66) and (6.66 ± 0.56), has compared significant difference (P < 0.05) with the aging group.
2. galactophore epithelial cell In vitro culture result of the test shows: 1. with compared with normal, these article can shorten galactophore epithelial cell population doubling time (P < 0.05), promote cell division index (P < 0.05), have significant difference; 2. use corn plumelet extract can not induce galactophore epithelial cell to synthesize casein merely; 3. serum starvation is cultivated and can be reduced cell-proliferation activity, and 20 mg/>L concentration and 40 mg/L concentration corn plumelet extracts can effectively delay the reduction (P < 0.05) of galactophore epithelial cell proliferation activity, has significant protective effect (P < 0.05).4. serum starvation is cultivated and can be induced the galactophore epithelial cell apoptosis, and apoptotic cells is expressed the bcl-2 gene; These article can inducing cell high expressed bcl-2 gene, and through analyzing, AO is respectively (0.3777 ± 0.0111) and (0.4163 ± 0.0134), compared with larva starvation group significant difference (P 0.05, P 0.01).5. compare with larva starvation group, these article can significantly promote galactophore epithelial cell total protein content (P < 0.05); 10 mg/>L concentration are compared there was no significant difference with larva starvation group.
3. the ischemic myocardial protection that oxidation caused:
(1) the rabbit treating myocardial ischemia damage protection test brought out of Iso: these article can alleviate the rabbit treating myocardial ischemia damage that Iso brings out.Experimental result shows that these article can alleviate the quickening of rabbit heart rate, the J point rising degree that Iso causes, improve myocardial tissue damage; Significantly or extremely significantly reduce AST in the serum, LDH, CK active (P 0.01 or P 0.05); Significantly or the utmost point significantly improve serum NO content (P 0.01 or P 0.05), in cardiac muscular tissue and the serum SOD and GSH-pX active (P 0.01 or P 0.05), and significantly or extremely significantly reduce MDA content in cardiac muscular tissue and the serum (P 0.01 or P 0.05).
(2) the rabbit treating myocardial ischemia damage protection test brought out of Pit: irritate these article of stomach as protection to rabbit in advance, after continuous 2 weeks, auricular vein is injected Pit (2.0 Ukg
-1, use the normal saline dilution to be 3ml, 20s at the uniform velocity injects), bring out the rabbit myocardial ischemia.The result shows, these article can suppress that the rabbit heart rate slows down due to the Pit, the S-T section is raised, the T wave height is alarmmed; Significantly or extremely significantly reduce AST in the serum, LDH, CK active (P 0.01 or P 0.05); Significantly or the utmost point significantly improve SOD and GSH-PX activity in the cardiac muscular tissue (P 0.01 or P 0.05), and significantly or extremely significantly reduce MDA content (P 0.01 or P 0.05).
(3) these article can alleviate the In vitro culture neonatal cardiac myocytes ischemic injuries that Iso brings out
The In vitro culture neonatal rat myocardial cell behind the adding Iso simulation myocardial ischemia 30min, adds these article.The result shows that these article can improve the myocardial cell form under the ischemic state, improves cell survival rate and cell density; Significantly or extremely significantly reduce AST in the cell culture fluid, LDH, CK active (P 0.01 or P 0.05); The utmost point significantly improves SOD and GSH-pX active (P < 0.01), significantly reduces MDA content (P < 0.05); Promote BCl-2 to express, suppress NF-κ B and express.
Comprehensive above-mentioned experimental result, these article have protective effect to the treating myocardial ischemia damage due to the oxidation.
4. these article are to base metabolism of mouse aging myocardial freedom and ultrastructure effects: with the inductive subacute aging model of D-galactose; These article of research are to the influence of mouse aging cardiac muscle activities of antioxidant enzymes, free-radical contents and lipid peroxidation product content, and from morphology, the anti-oxidative damage effect of EMP are investigated.The result shows: all be between each item index of (1) this drug protection group and aging model group utmost point significant difference (SOD:87.241 ± 3.849 U/mg ,+18.8%, P < 0.01; CAT:47.313 ± 2.195 U/>mg ,+36.4%, P < 0.01; GSH-Px:28.038 ± 1.583 U/>mg ,+37.6%, P < 0.01; MDA:11.300 ± 1.529 nmol/>mg ,-34.7%, P < 0.01; NO:6.438 ± 0.637 μ mol/>L ,-47.1%, P 0.01); (2) HE dyeing is observed, model group cardiac muscle fiber arrangement disorder, and twisting and breaking increases, and the space increases between fiber; Electron microscopic observation, model group cardiac muscle Z line broadens, blurs, sarcostyle fracture, dissolving, coagulation, mitochondrial swelling, vacuolation, ridge disappear; The above pathological changes of 20 mg/kg EMP protection groups has obtained tangible improvement.Above presentation of results, 20 mg/kg EMP have the mouse aging of enhancing cardiac muscle activities of antioxidant enzymes, improve the metabolism of myocardial freedom base, and the protecting myocardial cell ultrastructure is avoided the effect of free-radical oxidation damage.
5. these article are to the anti-aging effects of fruit bat: with the fruit bat is experimental subject research EMP to its reproductive capacity, anti-heat stress ability, food amount, moisture and the influence in life-span, and investigate the effect of EMP active MDA content in based on the inductive fruit bat aging model of D-galactose to SOD in the old and feeble fruit bat body.The result shows: (1) and blank group relatively, the drug group of 40 mg/kg can obviously improve fruit bat reproductive capacity, anti-heat stress ability (female fly: 75.250 ± 4.031 % ,+33.78 %, P < 0.01; Male fly: 63.750 ± 3.500 % ,+19.72 %, P 0.01), the food amount (female fly: 0.043 ± 0.003 g ,+22.86 %, P < 0.05; Male fly: 0.048 ± 0.002 g ,+23.08 %, P 0.05), moisture (female fly: 0.065 ± 0.004 g ,+14.04 %, P < 0.05; Male fly: 0.059 ± 0.002 g ,+20.41 %, P 0.01), average life (female fly: 66.23 ± 13.37 d ,+10.79 %, P < 0.01; Male fly: 63.96 ± 12.66 d ,+15.64 %, P 0.05) and the maximum life span life-span (female fly: 80.67 ± 2.08 d ,+14.15 %, P < 0.01; Male fly: 75.67 ± 1.53 d ,+10.74 %, P 0.05); (2) compare with model group, the SOD of medicament protection group is active significantly to raise (female fly: 40 d, P < 0.01; Male fly: 30 d, 40 d, P 0.05), MDA content obviously descend (female fly: 30 d, 40 d, P < 0.01; Male fly: 30 d, 40 d, P 0.01).Above result shows that these article can improve reproductive capacity, anti-heat stress ability, food amount, moisture and the life-span of fruit bat, and the intravital SOD of the old and feeble fruit bat that raises is active, reduces MDA content, the oxidative damage that antagonism D-galactose causes.
6. these article can raise extremely significantly that mouse aging testis tissue SOD is active, GSH-PX is active and NO content, serum T level, epididymal sperm number and sperm motility rate (P < 0.01), extremely significantly reduce MDA content (P < 0.01).Drug group spermatogenic cells of mouse testis number increases, arranges in order, and sperm number increases in the tube chamber.Spermatogenic cell organelle number increases, the mitochondrion complete form, and nucleus is clear.The Leydig cell number increases, and nucleus is clear, graininess distributes.And maybe the utmost point significantly improve former primary cultures of rat testis Leydig cell testosterone synthetic with excretory ability (P < 0.01), keep the cellularity integrity.
In sum, preparation of the present invention has remarkable result for the various physiological function declines of developing human activity's delaying human body, has no side effect, and is suitable for each age group, particularly middle-aged and elderly people and takes.
Accurately take by weighing EL40 28g, ethyl acetate 9g, Quercetin 5.8g, PEG200 4g stirs at room temperature (25 ℃) condition lower magnetic force agitator, then to wherein slowly splashing into the distilled water that has dissolved Herba Apii graveolentis extract and Agaricus campestris extract.Increase along with the distillation water yield; The system stickiness increases, and when the distillation water yield made that system becomes the oil-in-water type nano-emulsion by Water-In-Oil, the system viscosity was thinning from the most heavy-gravity state; What produced this moment is water white compound recipe quercetin nano breast; The Herba Apii graveolentis water extract 5.2g that adds, mushroom water extract 4.7g, distilled water 43.3 g.This ratio is the optimal proportion of Quercetin resisting hypertension nano-emulsion.
Following examples step is with embodiment 1:
Embodiment 2
Quercetin 6g, Tween 80 24g, isopropyl myristate 12g, ethanol 12g, Herba Apii graveolentis water extract 4g, mushroom water extract 4g, distilled water 46g.
Embodiment 3
Quercetin 4g, RH40 28g, oleic acid 10g, PEG400 3g, Herba Apii graveolentis water extract 5g, mushroom water extract 7g, distilled water 43g.
Embodiment 4
Quercetin 4.7g, EL40 castor oil hydrogenated 21g, ethyl oleate 7g, glycerin 3g, Herba Apii graveolentis water extract 3.5g, mushroom water extract 6.5g, distilled water 54.3g.
Quercetin 8g, poloxamer 188 25g, isopropyl myristate 10g, PEG200 12g, Herba Apii graveolentis water extract 6g, mushroom water extract 3g, distilled water 36g.
Embodiment 6
Quercetin 7.1g, RH40 22g, soybean oil 10g, Macrogol 600 17g, Herba Apii graveolentis water extract 2g, mushroom water extract 4g, distilled water 37.9g.
Embodiment 7
Quercetin 1g, Tween 80 15g, isopropyl myristate 5g, ethanol 15g, Herba Apii graveolentis water extract 15g, mushroom water extract 15g, distilled water 34g.
Embodiment 8
Quercetin 3g, RH40 15g, oleic acid 8g, PEG400 12g, Herba Apii graveolentis water extract 12g, mushroom water extract 12g, distilled water 38g.
Embodiment 9
Quercetin 5g, EL40 20g, ethyl oleate 11g, glycerin 9g, Herba Apii graveolentis water extract 9g, mushroom water extract 9g, distilled water 37g.
Quercetin 7g, poloxamer 188 25g, isopropyl myristate 14g, PEG200 7g, Herba Apii graveolentis water extract 7g, mushroom water extract 7g, distilled water 33g.
Embodiment 11
Quercetin 9g, RH40 30g, soybean oil 17g, Macrogol 600 5g, Herba Apii graveolentis water extract 5g, mushroom water extract 5g, distilled water 39g.
Embodiment 12
Quercetin 12g, Tween 80 35g, isopropyl myristate 21g, ethanol 3g, Herba Apii graveolentis water extract 3g, mushroom water extract 3g, distilled water 23g.
Embodiment 13
Quercetin 15g, RH40 40g, oleic acid 25g, PEG400 1g, Herba Apii graveolentis water extract 1g, mushroom water extract 1g, distilled water 27g.
Claims (2)
1. compound recipe quercetin nano breast antisenescence health product is characterized in that its raw material and mass percent thereof are:
Quercetin 1%～15%
Surfactant 15%～40%
Cosurfactant 1%～15%
Oil 5%～25%
Herba Apii graveolentis water extract 1%～15%
Mushroom water extract 1%～15%
All the other compositions are distilled water, and the mass percent sum of above-mentioned raw materials is 100%;
Described surfactant is: any one in polyoxyl 40 hydrogenated castor oil, castor oil polyoxyethylene ether 40, Tween 80 or the poloxamer 188 or with the mixture of span80;
Described oil is any one or a few the mixture in the lipids such as soybean oil, Oleum Brassicae campestris, isopropyl myristate, ethyl acetate, ethyl oleate or oleic acid;
Described cosurfactant is a dehydrated alcohol, 1, the mixture of any one or a few in 2-propylene glycol, PEG400 or the glycerin.
2. compound recipe quercetin nano breast antisenescence health product according to claim 1, it is characterized in that: the particle diameter of this medicine is between 67.1～92.4nm.
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| CN103948543A (en) * | 2014-05-11 | 2014-07-30 | 张晓燕 | Yunnan white powder nanoemulsion and preparation method thereof |
| WO2015070280A1 (en) * | 2013-11-14 | 2015-05-21 | Newsouth Innovations Pty Limited | Senescence and senescence associated secretory phenotype |
| WO2017215526A1 (en) * | 2016-06-15 | 2017-12-21 | 南京简庄生物技术有限公司 | A topical preparation for protection and reparation of skin tissue |
| CN113197913A (en) * | 2021-04-16 | 2021-08-03 | 一力制药股份有限公司 | A pharmaceutical composition for improving sleep, and its preparation method |
| US11389469B2 (en) | 2015-04-28 | 2022-07-19 | Newsouth Innovations Pty Ltd | Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity |
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2012
- 2012-05-10 CN CN2012101427452A patent/CN102631385A/en active Pending
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| CN103948543A (en) * | 2014-05-11 | 2014-07-30 | 张晓燕 | Yunnan white powder nanoemulsion and preparation method thereof |
| US11389469B2 (en) | 2015-04-28 | 2022-07-19 | Newsouth Innovations Pty Ltd | Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity |
| WO2017215526A1 (en) * | 2016-06-15 | 2017-12-21 | 南京简庄生物技术有限公司 | A topical preparation for protection and reparation of skin tissue |
| CN107510690A (en) * | 2016-06-15 | 2017-12-26 | 南京简庄生物技术有限公司 | A kind of external skin organization protection and preparation for repairing |
| US10561640B2 (en) | 2016-06-15 | 2020-02-18 | Nanjing Jianzhuang Biotechnology Limited Company | Topical preparation for skin tissue protection and reparation |
| CN107510690B (en) * | 2016-06-15 | 2021-03-19 | 南京简庄生物技术有限公司 | External preparation for protecting and repairing skin tissue |
| CN113197913A (en) * | 2021-04-16 | 2021-08-03 | 一力制药股份有限公司 | A pharmaceutical composition for improving sleep, and its preparation method |
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Application publication date: 20120815 |