CN102631196B - Three-dimensional visualization method and system of magnetic resonance elastography - Google Patents
Three-dimensional visualization method and system of magnetic resonance elastography Download PDFInfo
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Abstract
The invention discloses a three-dimensional visualization method of magnetic resonance elastography, comprising the following steps: stimulating an imaged object, applying sensitive gradient on three mutually perpendicular directions and scanning to obtain the initial phase image data of the imaged object at the three mutually perpendicular directions; changing the initial phase of the stimulation and scanning the imaged object to obtain the phase change image data of the imaged object at the three mutually perpendicular directions; constructing a three-dimensional visual model according to the initial phase image data and the phase change image data and setting up an image. In the three-dimensional visualization method of magnetic resonance elastography, the initial phase image data and the phase change image data, namely the three-dimensional image data along with variation of time, are obtained by changing the initial phase of the stimulation, which means so as to construct the three-dimensional visual model of the magnetic resonance elastography to realize three-dimensional visualization of the magnetic resonance elastography. In addition, a system for three-dimensional visualization of magnetic resonance elastography is provided.
Description
[technical field]
The present invention relates to magnetic resonance arts, particularly relate to a kind of magnetic resonance elastography three-dimensional visualization method and system.
[background technology]
Magnetic resonance elastography (Magnetic Resonance Elastography, MRE) be that Muthupillai equals a kind of dynamic imaging technique that nineteen ninety-five proposes, its ultimate principle is based on mr imaging technique detection bodies inner tissue and externally encourages the particle displacement produced under the mechanical wave effect, calculates thus (shearing) coefficient of elasticity scattergram of detected tissue.Elasticity (or hardness) is a kind of important Mechanics of Machinery parameter in the tissue physical property, and the elastic modelling quantity of biological tissue or hardness depend on its molecular composition and corresponding microstructure, with its biological characteristics, are closely related.The Flexible change of biological tissue is normal to be closely related with pathological phenomenon, and often there are the difference of elastic modelling quantity or hardness in pathological tissues and normal structure, and this species diversity is significant in clinical disease diagnosis and discriminating.Traditional formation method, as ultrasonic, CT, nuclear magnetic resonance all can not provide the information of tissue biological's terms of mechanics, and magnetic resonance elastography can intuitively show and quantize the inside of human body tissue elasticity as a kind of novel noinvasive formation method, and the elastogram to organizing, make " image palpation " become possibility, there is good development potentiality and application prospect in medical diagnosis.
In traditional magnetic resonance elastography, can only directly observe the two-dimentional fluctuating picture obtained, the magnetic resonance elastography phase diagram collected, analyze the propagation condition of shearing wave in imaging object.At present, there is no the corresponding three-dimensional visualization method of magnetic resonance elastography, can't produce understanding intuitively to the propagation condition in the three dimensions of shearing wave.
[summary of the invention]
Based on this, be necessary to provide a kind of magnetic resonance elastography three-dimensional visualization method of three-dimensional visualization.
A kind of magnetic resonance elastography three-dimensional visualization method, comprise the following steps: imaging object is encouraged, apply the line scanning of going forward side by side of responsive gradient on three orthogonal directions, obtain the initial phase view data of imaging object on three orthogonal directions; Change the initial phase of described excitation, imaging object is scanned, obtain the phase change view data of imaging object on three orthogonal directions; Build three-dimensional visualization model and set up image according to described initial phase view data and described phase change view data.
Further, also comprise the step of imaging object being carried out to layering; Described imaging object is encouraged, apply the line scanning of going forward side by side of responsive gradient on three orthogonal directions, the step that obtains the initial phase view data of imaging object on three orthogonal directions is specially: described imaging object is encouraged, respectively described each layer of imaging object applied to responsive gradient on three orthogonal directions, the line scanning of going forward side by side, obtain the initial phase view data of each layer of imaging object on three orthogonal directions; The initial phase of the described excitation of described change, imaging object is scanned, the step that obtains the phase change view data of imaging object on three orthogonal directions is specially: the initial phase that changes described excitation, and respectively described each layer of imaging object scanned, obtain the phase change view data of described each layer of imaging object on three orthogonal directions.
Further, described three orthogonal directions are imaging object transverse axis position, Coronal and sagittal plain direction.
Further, the initial phase of the described excitation of described change, imaging object is scanned, the step that obtains the phase change view data of imaging object on three orthogonal directions is specially: repeatedly change the initial phase of described excitation, the phase contrast interval of the initial phase after adjacent two changes equates; Respectively imaging object is scanned, obtained a plurality of phase change view data of imaging object on three orthogonal directions that wait the initial phase spacing.
Further, initial phase is changed into respectively 90 degree, 180 degree, 270 degree.
In addition, also be necessary to provide a kind of magnetic resonance elastography three-dimension visible sysem of three-dimensional visualization.
A kind of magnetic resonance elastography three-dimension visible sysem, comprise exciting bank and video generation device; Described exciting bank is for being encouraged imaging object, also for changing the initial phase of described excitation; Described video generation device is connected with described exciting bank, and described video generation device comprises sampling module and three dimensional stress module; Sampling module, for described imaging object being applied on three orthogonal directions to the line scanning of going forward side by side of responsive gradient, obtains initial phase view data and the phase change view data of imaging object on three orthogonal directions; The three dimensional stress module is connected with described sampling module, for according to described initial phase view data and phase change view data, building three-dimensional visualization model and set up image.
Further, described video generation device also comprises processing module, and described processing module is connected with described sampling module, for imaging object is carried out to layering; Described sampling module applies the line scanning of going forward side by side of responsive gradient specifically for respectively described each layer of imaging object being applied on three orthogonal directions responsive gradient, obtains initial phase view data and the phase change view data of each layer of imaging object on three orthogonal directions.
Further, described three orthogonal directions are imaging object transverse axis position, Coronal and sagittal plain direction.
Further, described exciting bank also is specially for the initial phase that changes described excitation: described exciting bank repeatedly changes the initial phase of described excitation, and the phase contrast interval of the initial phase after adjacent two changes equates.
Further, initial phase is changed into respectively 90 degree, 180 degree, 270 degree.
In above-mentioned magnetic resonance elastography three-dimensional visualization method and system, by the initial phase changing excitation, obtain initial phase view data and phase change view data, the 3 d image data changed in time, build the three-dimensional visualization model of magnetic resonance elastography, realize the three-dimensional visualization of magnetic resonance elastography.
[accompanying drawing explanation]
The flow chart that Fig. 1 is the magnetic resonance elastography three-dimensional visualization method;
The particular flow sheet that Fig. 2 is magnetic resonance elastography three-dimensional visualization method shown in Fig. 1;
The particular flow sheet of the magnetic resonance elastography three-dimensional visualization method that Fig. 3 is an embodiment;
The module map that Fig. 4 is the magnetic resonance elastography three-dimension visible sysem;
The detailed block diagram of the magnetic resonance elastography three-dimension visible sysem that Fig. 5 is an embodiment.
[specific embodiment]
Can't to carry out the problem of effective visual understanding to the propagation condition in the three dimensions of shearing wave in order solving, to have proposed a kind of magnetic resonance elastography three-dimensional visualization method of three-dimensional visualization.
According to nuclear magnetic resonance image, gain knowledge, the minimum unit in imaging space is pixel, and imaging space is divided into sagittal plain direction, cross-section position direction and three directions of Coronal direction usually according to imaging object.Mutually vertical in twos between sagittal plain direction, cross-section position direction and Coronal direction.
Magnetic resonance elastography three-dimensional visualization method as shown in Figure 1 comprises the following steps:
Step S10, encouraged imaging object, applies the line scanning of going forward side by side of responsive gradient on three orthogonal directions, obtains the initial phase view data of imaging object on three orthogonal directions.
Apply shearing wave on the imaging object surface it is encouraged, excitation makes the particle on imaging object displacement occur.Select three orthogonal directions to apply responsive gradient, imaging object is scanned, can collect respective direction fluctuating picture data, obtain the initial phase view data of imaging object on three orthogonal directions after having scanned.
Step S20, change the initial phase encouraged, and imaging object is scanned, and obtains the phase change view data of imaging object on three orthogonal directions.As shown in Figure 2, step S20 comprises:
Step S210, repeatedly change the initial phase encouraged, and the phase contrast interval of the initial phase after adjacent two changes equates.Specifically in the present embodiment, during beginning, initial phase is 0 degree, and initial phase is changed into respectively 90 degree, 180 degree and 270 degree afterwards.
Step S230, scanned imaging object respectively, obtains a plurality of phase change view data of imaging object on three orthogonal directions that wait the initial phase spacing.Specifically in the present embodiment, along with the change of initial phase, finally obtain time dependent phase image data.It should be noted that, initial phase also can change over other the number of degrees, three times of being not limited to mention in the present embodiment of the change number of times of initial phase, if times of collection is 8 times, initial phase can be changed into respectively 45 degree, 90 degree, 135 degree, 180 degree, 225 degree, 270 degree, 315 degree.The phase contrast of the initial phase after adjacent two changes, between adjacent initial phase, number of degrees interval also can be unequal, and in embodiment, initial phase is changed into respectively 90 degree, 180 degree and 270 are spent is in order better to reflect that phase image is over time.
Step S30, build three-dimensional visualization model and set up image according to initial phase view data and phase change view data.
The initial phase view data and the phase change view data that according to above-mentioned steps, collect build three-dimensional visualization model, and the phase image obtained is the linear transformation of fluctuation displacement,
Wherein,
for position vector; X, y, z is respectively three vectors on mutually perpendicular direction.
γ is gyromagnetic ratio.
The periodicity that N is the motion sensitive gradient that applies.
The cycle that T is mechanical excitation.
The size that G is responsive gradient.
This formula is converted, can be obtained the displacement vector of this direction:
The fluctuation displacement vector of three directions of combination forms motion vector.Utilize this displacement vector to build the three dimensional display model, the coordinate of establishing each pixel of original state is P (x, y, z), after adding fluctuation, sets up three-dimensional visualization model:
P (x ', y ', z ') for adding the coordinate of rear each pixel of fluctuation.
Finally according to three-dimensional visualization model, set up image.
In above-mentioned magnetic resonance elastography three-dimensional visualization method, the initial phase encouraged by change, obtain initial phase view data and phase change view data, the 3 d image data changed in time, build the three-dimensional visualization model of magnetic resonance elastography, realize the three-dimensional visualization of magnetic resonance elastography.In this three-dimensional visualization model, take the time as axle, the phase place change demonstration of excitation, can observe fluctuation communication process in time, take space as axle, i.e. the direction of propagation of excitation demonstration can be observed the communication process of fluctuation with space.
It is pointed out that, in order to better meet the needs of magnetic resonance imaging and medical science, above-mentioned three orthogonal directions are preferably transverse axis position, Coronal and the sagittal plain direction of imaging object.But above-mentioned three orthogonal directions are not limited to transverse axis position, Coronal and the sagittal plain direction of imaging object, only need three directions mutually vertically to get final product in twos in imaging space, three orthogonal directions just can the visual needs of capable of meeting requirements on three-dimensional.
Owing to having certain displacement difference between neighbor pixel, original shift value is less, is difficult to observe, and therefore need carry out the stretching of some scale to shift value, can produce " fluctuation " effect.The size that means motion vector mould value by different colors, make ripple effect more lively.
As shown in Figure 3, the magnetic resonance elastography three-dimensional visualization method of an embodiment comprises:
Step S100, carry out layering to imaging object.
Step S200, encouraged imaging object, respectively each layer of imaging object applied to responsive gradient on three orthogonal directions, and the line scanning of going forward side by side obtains the initial phase view data of each layer of imaging object on three orthogonal directions.
Thickness according to setting carries out the layering processing to imaging object on a direction, and it is divided into to multilamellar.Imaging object is encouraged, apply respectively the responsive gradient of three orthogonal directions on each layer, the line scanning of going forward side by side, obtain the initial phase view data of each layer of imaging object on three orthogonal directions.
Step S300, change the initial phase of excitation, and respectively each layer of imaging object scanned, and obtains the phase change view data of each layer of imaging object on three orthogonal directions.
After changing initial phase, each layer of imaging object scanned respectively, obtained the phase change view data of each layer of imaging object on three orthogonal directions.
Step S400, build three-dimensional visualization model according to initial phase view data and phase change view data.
In conjunction with before the initial phase view data of resulting each layer of imaging object on three orthogonal directions, finally obtain an x*y*N*3*N
afive dimensional data images, wherein, N is the number of plies that imaging object divided, N
afor the phase change number of times.Finally according to initial phase view data and the phase change view data of gained, build three-dimensional visualization model and set up image.
In the present embodiment, by imaging object being carried out to layering go forward side by side row energization and scanning, can at the propagation condition of interior of articles, be familiar with more intuitively shearing wave.
Refer to shown in Fig. 4, a kind of magnetic resonance elastography three-dimension visible sysem of three-dimensional visualization also is provided, this magnetic resonance elastography three-dimension visible sysem comprises exciting bank 100 and video generation device 300, and video generation device 300 is connected with exciting bank 100.
320 pairs of imaging objects of sampling module apply the line scanning of going forward side by side of responsive gradient on three orthogonal directions, can collect respective direction fluctuating picture data, obtain the initial phase view data of imaging object on three orthogonal directions after having scanned.Specifically in the present embodiment, during beginning, initial phase is 0 degree, exciting bank 100 is changed into respectively 90 degree, 180 degree and 270 degree by initial phase afterwards, and scanned by sampling module 320, obtain a plurality of phase change view data of imaging object on three orthogonal directions that wait the initial phase spacing.Along with the change of initial phase, final sampling module 320 scannings obtain time dependent phase image data.
It should be noted that, initial phase also can change over other the number of degrees, three times of being not limited to mention in embodiment of the change number of times of initial phase, the phase contrast interval of the initial phase after adjacent two changes also can be unequal, and in embodiment, initial phase is changed into respectively 90 degree, 180 degree and 270 are spent is in order better to reflect that phase image over time.
Three dimensional stress module 340 is for building three-dimensional visualization model and set up image according to initial phase view data and phase change view data.Initial phase view data and phase change view data are processed, built three-dimensional visualization model, and set up image according to three-dimensional visualization model.
In above-mentioned magnetic resonance elastography three-dimension visible sysem, the initial phase encouraged by change, obtain initial phase view data and phase change view data, the 3 d image data changed in time, build the three-dimensional visualization model of magnetic resonance elastography, realize the three-dimensional visualization of magnetic resonance elastography.In this three-dimensional visualization model, take the time as axle, the phase place change demonstration of excitation, can observe fluctuation communication process in time.Take space as axle, i.e. the direction of propagation of excitation demonstration, can observe the communication process of fluctuation with space.
Due to the characteristic of magnetic resonance elastography based on the magnetic resonance phase correlation technique, in the scanning impulse sequence, add the motion sensitive gradient to detect the information of proton motion, the cycle of motion sensitive gradient must be consistent with the cycle of external vibration.Video generation device is connected with exciting bank, and the shearing wave that makes exciting bank produce is synchronizeed with the motion sensitive gradient in the nuclear magnetic resonance sequence in video generation device.
It is pointed out that, in order to better meet the needs of magnetic resonance imaging and medical science, above-mentioned three orthogonal directions are preferably transverse axis position, Coronal and the sagittal plain direction of imaging object.But three orthogonal directions are not limited to transverse axis position, Coronal and the sagittal plain direction of imaging object, only need three directions mutually vertically to get final product in twos in imaging space, three orthogonal directions just can the visual needs of capable of meeting requirements on three-dimensional.
In one embodiment, refer to Fig. 5, above-mentioned magnetic resonance elastography three-dimension visible sysem, video generation device 300 also comprises processing module 310, processing module 310 is connected with sampling module 320.
Processing module 310 is for carrying out layering to imaging object.Thickness according to setting carries out the layering processing to imaging object on a direction initialization, and it is divided into to multilamellar.
After changing initial phase, each layer of imaging object scanned respectively, obtained the phase change view data of each layer of imaging object on three orthogonal directions.Apply respectively the responsive gradient of three orthogonal directions on each layer, the line scanning of going forward side by side, obtain the initial phase view data of each layer of imaging object on three orthogonal directions.An x*y*N*3*N of final acquisition
afive dimensional data images, wherein, N is the number of plies that imaging object divided, N
afor the phase change number of times.Finally according to initial phase view data and the phase change view data of gained, build three-dimensional visualization model and set up image.
In the present embodiment, by imaging object being carried out to layering go forward side by side row energization and scanning, can show more intuitively by the propagation condition at interior of articles shearing wave.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. a magnetic resonance elastography three-dimensional visualization method, is characterized in that, comprises the following steps:
Imaging object is encouraged, applied the line scanning of going forward side by side of responsive gradient on three orthogonal directions, obtained the initial phase view data of imaging object on three orthogonal directions;
Change the initial phase of described excitation, imaging object is scanned, obtain the phase change view data of imaging object on three orthogonal directions;
Build three-dimensional visualization model and set up image according to described initial phase view data and described phase change view data; The described step that builds three-dimensional visualization model and set up image according to described initial phase view data and described phase change view data is specially: the phase change image obtained is the linear transformation of fluctuation displacement; The fluctuation displacement vector of three directions of combination forms motion vector; If the coordinate of each pixel of original state, add the fluctuation displacement, set up three-dimensional visualization model; Carry out three dimensional display according to three-dimensional visualization model.
2. magnetic resonance elastography three-dimensional visualization method according to claim 1, is characterized in that, also comprises the step of imaging object being carried out to layering;
Described imaging object is encouraged, apply the line scanning of going forward side by side of responsive gradient on three orthogonal directions, the step that obtains the initial phase view data of imaging object on three orthogonal directions is specially:
Described imaging object is encouraged, respectively described each layer of imaging object applied to responsive gradient on three orthogonal directions, the line scanning of going forward side by side, obtain the initial phase view data of each layer of imaging object on three orthogonal directions;
The initial phase of the described excitation of described change, scanned imaging object, and the step that obtains the phase change view data of imaging object on three orthogonal directions is specially:
Change the initial phase of described excitation, and respectively described each layer of imaging object scanned, obtain the phase change view data of described each layer of imaging object on three orthogonal directions.
3. magnetic resonance elastography three-dimensional visualization method according to claim 1, is characterized in that, transverse axis position, Coronal and sagittal plain direction that described three orthogonal directions are imaging object.
4. magnetic resonance elastography three-dimensional visualization method according to claim 1, it is characterized in that, the initial phase of the described excitation of described change, scanned imaging object, and the step that obtains the phase change view data of imaging object on three orthogonal directions is specially:
Repeatedly change the initial phase of described excitation, the phase contrast interval of the initial phase after adjacent two changes equates;
Respectively imaging object is scanned, obtained a plurality of phase change view data of imaging object on three orthogonal directions that wait the initial phase spacing.
5. magnetic resonance elastography three-dimensional visualization method according to claim 4, is characterized in that, initial phase is changed into respectively 90 degree, 180 degree, 270 degree.
6. a magnetic resonance elastography three-dimension visible sysem, is characterized in that, comprising:
Exciting bank, for being encouraged imaging object, also for changing the initial phase of described excitation; And
Video generation device, be connected with described exciting bank, and described video generation device comprises:
Sampling module, for described imaging object being applied on three orthogonal directions to the line scanning of going forward side by side of responsive gradient, obtain initial phase view data and the phase change view data of imaging object on three orthogonal directions; And
The three dimensional stress module, be connected with described sampling module, for according to described initial phase view data and phase change view data, building three-dimensional visualization model and set up image; The described method that builds three-dimensional visualization model and set up image according to described initial phase view data and described phase change view data is specially: the phase change image obtained is the linear transformation of fluctuation displacement; The fluctuation displacement vector of three directions of combination forms motion vector; If the coordinate of each pixel of original state, add the fluctuation displacement, set up three-dimensional visualization model; Carry out three dimensional display according to three-dimensional visualization model.
7. magnetic resonance elastography three-dimension visible sysem according to claim 6, is characterized in that, described video generation device also comprises:
Processing module, be connected with described sampling module, for described imaging object is carried out to layering;
Described sampling module, specifically for respectively described each layer of imaging object being applied on three orthogonal directions the line scanning of going forward side by side of responsive gradient, obtains initial phase view data and the phase change view data of each layer of imaging object on three orthogonal directions.
8. magnetic resonance elastography three-dimension visible sysem according to claim 6, is characterized in that, transverse axis position, Coronal and sagittal plain direction that described three orthogonal directions are imaging object.
9. magnetic resonance elastography three-dimension visible sysem according to claim 6, is characterized in that, described exciting bank also is specially for the initial phase that changes described excitation:
Described exciting bank repeatedly changes the initial phase of described excitation, and the phase contrast interval of the initial phase after adjacent two changes equates.
10. magnetic resonance elastography three-dimension visible sysem according to claim 9, is characterized in that, initial phase is changed into respectively 90 degree, 180 degree, 270 degree.
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| CN109358303B (en) * | 2018-12-07 | 2021-04-02 | 上海联影医疗科技股份有限公司 | Scanning method for magnetic resonance imaging and diffusion tensor imaging system |
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