CN102626471B - Traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration - Google Patents
Traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration Download PDFInfo
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- CN102626471B CN102626471B CN 201210080725 CN201210080725A CN102626471B CN 102626471 B CN102626471 B CN 102626471B CN 201210080725 CN201210080725 CN 201210080725 CN 201210080725 A CN201210080725 A CN 201210080725A CN 102626471 B CN102626471 B CN 102626471B
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Abstract
The invention belongs to the field of medicine technology, and in particular relates to a traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration. The traditional Chinese medicine composition of the invention selects four medicinal materials of wild grapevine, Chinese actinidia root, almond and Ganoderma lucidum. Modern pharmacology research and clinical trials have shown that the traditional Chinese medicine composition of the invention has functions of antibiosis, reducing inflammation, relieving, promoting epidermal regeneration and enhancing the vitality thereof, can be effectively resist anaphylaxis and help the skin repair and reconstruction, so as to achieve effects of anti-anaphylaxis, desensitization, repair, regeneration, whitening wrinkle proof, beautifying. Meanwhile, the medicinal materials have no toxicity and little drug dependence for long-term use, and are at low prices; therefore, the traditional Chinese medicine composition is suitable for ordinary consumers to use, and has wide market prospect.
Description
Technical field
The invention belongs to medical technical field, relate in particular to a kind of Chinese medicine composition with anti-anaphylaxis desensitization, reparative regeneration effect.
Background technology
Quickening work along with people's rhythm of life, work and life stress increase increasingly, add environmental pollution and diet problem, people's skin problem is highlighted gradually, dim complexion, pachylosis sensitivity, pore expansion, brown patch, acne, tiny wrinkle etc. are perplexing the vast women who likes to be beautiful.Along with the raising of people's living standard and to healthy attention, how to keep whitening skin delicacy, soft smooth high resilience, improve skin sensitivity, avoid irritated generation, the state of maintaining the beautiful youth is the problem that people extremely are concerned about.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Chinese medicine composition with anti-anaphylaxis desensitization, reparative regeneration effect, the damaged skin that described Chinese medicine composition can be repaired a variety of causes makes skin regeneration, improve the skin allergic symptom, improve the toleration of skin to anaphylactogen, have that whitening is wrinkle resistant, the effect of cleaning and nourishing simultaneously concurrently.
For realizing purpose of the present invention, the present invention adopts following technical scheme:
A kind of Chinese medicine composition with anti-anaphylaxis desensitization, reparative regeneration effect, by waiting following raw material of weight portion to make: Herba Anemones vitifoliae extract, Radix Actinidiae Chinensis Chinensis extrat, Semen Armeniacae Amarum extract, Ganoderma extract.
Chinese medicine composition of the present invention selects the extract of four flavor Chinese crude drugs such as Herba Anemones vitifoliae, Radix Actinidiae Chinensis, Semen Armeniacae Amarum and Ganoderma to be mixed.
Wherein, Herba Anemones vitifoliae, the another name Herba Anemones vitifoliae, be Herb and the leaf of vitaceae downy grape, sweet in the mouth, property are flat, have the effect of hemostasis, clearing away heat-damp and promoting diuresis, antiabortive, analgesic, subduing swelling and detoxicating, cure mainly the diseases such as measles, dysentery, sore swollen toxin.
The root that Radix Actinidiae Chinensis is Actinidiaceae plant Actinidia arguta Sieb.et Zucc, sour in the mouth, puckery, cool in nature, effect with heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, expelling wind and removing dampness, diuresis hemostasis, removing toxic substances and promoting subsidence of swelling, hemostasis, cure mainly the diseases such as jaundice, dyspepsia, vomiting, rheumatic arthralgia, Alimentary Tract Cancer, carbuncle and ulcer furuncle, traumatic injury, traumatic hemorrhage, agalactia, rheumatic ostalgia and jaundice.
The seed that Semen Armeniacae Amarum is rosaceous plant peach, Amygdaluscommunis L., Fructus Pruni, Lee, prunus mume (sieb.) sieb.et zucc., whitethorn, Folium Eriobotryae etc., warm in nature, bitter in the mouth, slightly poisonous, there is the effect of sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation, the treatment of the disease such as, hot dry constipation withered for cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin.
Ganoderma claims again Ganoderma lucidum seu Japonicum, Ganoderma, Ganoderma lucidum seu Japonicum, Herba mesonae chinensis, Ganoderma, is the Herb of Polyporaceae plant Ganoderma lucidum (Leyss. Ex Fr.) Karst. or Ganoderma, and sweet in the mouth, property are put down, and cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.
The described Herba Anemones vitifoliae extract of Chinese medicine composition of the present invention, Radix Actinidiae Chinensis Chinensis extrat, Semen Armeniacae Amarum extract and Ganoderma extract are commercial product, can buy and obtain by commercial channel, also can prepare.
Preferably, the preparation method of described Herba Anemones vitifoliae extract is: get the decocting that Herba Anemones vitifoliae adds 6-8 times of weight and boil 2-4 time, and each 1-3 hour, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
Preferably, the preparation method of described Radix Actinidiae Chinensis Chinensis extrat is: get the decocting that Radix Actinidiae Chinensis adds 6-8 times of weight and boil 2-4 time, and each 1-3 hour, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
Preferably, the preparation method of described Semen Armeniacae Amarum extract is: get the decocting that Semen Armeniacae Amarum adds 6-8 times of weight and boil 2-4 time, and each 1-3 hour, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
Preferably, the preparation method of described Ganoderma extract is: get the decocting that Ganoderma adds 6-8 times of weight and boil 2-4 time, and each 1-3 hour, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
The present invention also provides the clinical preparation of described Chinese medicine composition.Those skilled in the art can add Chinese medicine composition of the present invention according to different patients' demand that to prepare different dosage form be required various pharmaceutically conventional adjuvants, as disintegrating agent, lubricant, emulsifying agent, binding agent etc., with conventional method of Chinese medicinal, through the direct or indirect acceptable adjuvant pharmaceutically that adds of routine processing, make common dosage forms as tablet, capsule, oral liquid, pill, granule, powder, drop pill, spray, emulsifiable paste etc.
Preferably, the clinical preparation of Chinese medicine composition of the present invention is emulsifiable paste, can directly act on affected part, and with strong points, curative effect is obvious.
The invention provides a kind of emulsifiable paste with anti-anaphylaxis desensitization, reparative regeneration effect, made by following weight portion raw material:
Described Chinese medicine composition 20g, glyceryl monostearate 35g, stearic acid 130g, liquid Paraffin 50mL, azone 20mL, simethicone 20g, Borax 4g, allantoin 3g, glycerol 50mL, propylene glycol 50mL, ethyl hydroxybenzoate 1.5g, dodecylphosphoric acid sodium 4g, triethanolamine 10mL and purified water 653mL with anti-anaphylaxis desensitization, reparative regeneration effect.
The invention provides the described preparation method with emulsifiable paste of anti-anaphylaxis desensitization, reparative regeneration effect, comprise the following steps
Step 1: get glyceryl monostearate, stearic acid, liquid Paraffin, azone and simethicone be mixed and heated to 85 ℃ standby;
Step 2: get have anti-anaphylaxis desensitization, the Chinese medicine composition of reparative regeneration effect, glycerol, Borax, sodium lauryl sulphate, allantoin, purified water, ethyl hydroxybenzoate, mixed with propylene glycol of the present invention, be heated to 85 ℃, then add triethanolamine to continue to be heated to 85 ℃, mix to emulsifying with step 1 mixture, cooling, obtain.
Using dosage and the using method of pharmaceutical composition of the present invention depend on factors, comprise activity intensity, Time of Administration, metabolic rate, coincident with severity degree of condition and diagnosis and treatment doctor's the subjective judgment of patient's age, body weight, sex, natural health situation, nutriture, compound.Those skilled in the art can easily determine using dosage and the using method of pharmaceutical composition according to above-mentioned factor.
Preferably, its effective dose of pharmaceutical composition of the present invention is calculated with contained crude drug amount in Chinese medicine composition of the present invention, is each 2g, 2 times on the one.
The present invention, through clinical observation on the therapeutic effect, in 60 routine patients with allergic dermatosis, uses traditional Chinese medicine composition for treating of the present invention, cures 54 examples, and cure rate accounts for 90%, produce effects 5 examples, and total effective rate is 98.3%, invalid 1 example, inefficiency accounts for 1.7%.In 60 routine acne scars patients, use traditional Chinese medicine composition for treating of the present invention, cure 12 examples, cure rate accounts for 20%, produce effects 43 examples, total effective rate is 91.7%, invalid 5 examples, inefficiency accounts for 8.3%.Continue to use emulsifiable paste of the present invention more than half a year, cure rate obviously increases.The 60 routine patients with allergic dermatosis for the treatment of and 60 routine acne scars patients, do not have an example untoward reaction to occur, shows that Chinese medicine composition of the present invention is nontoxic to human-body safety.
The anti-anaphylaxis that has that the invention provides a kind of determined curative effect desensitizes, the Chinese medicine composition of reparative regeneration effect, modern pharmacology research and clinical trial show, Chinese medicine composition of the present invention has antibiotic, antiinflammatory, the effect of releiving and promoting promoting epidermization and improving its vitality, antiallergic effectively, the help skin repair is rebuild, reach the anti-anaphylaxis desensitization, reparative regeneration, whitening is wrinkle resistant, cleaning and nourishing, the effect of looks improving and the skin nourishing, medical material used is all nontoxic simultaneously, the life-time service drug dependence is little, and cheap, being applicable to ordinary consumer uses, there is wide market prospect.
The specific embodiment
The embodiment of the invention discloses a kind of anti-anaphylaxis desensitization, reparative regeneration drug composition on that has.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they all are deemed to be included in the present invention.Chinese medicine composition of the present invention is described by preferred embodiment, the related personnel obviously can be changed Chinese medicine composition as herein described or suitably change and combination within not breaking away from content of the present invention, spirit and scope, realizes and apply the technology of the present invention.
In order further to understand the present invention, below in conjunction with embodiment, to the invention provides, be elaborated.
Embodiment 1: the Chinese medicine composition of anti-anaphylaxis desensitization of the present invention, reparative regeneration effect
Described Chinese medicine composition is to be made by the crude drug of following weight portion:
Herba Anemones vitifoliae extract 5g, Radix Actinidiae Chinensis Chinensis extrat 5g, Semen Armeniacae Amarum extract 5g, Ganoderma extract 5g.
The preparation method of Herba Anemones vitifoliae extract is: gets the decocting that Herba Anemones vitifoliae adds 6 times of weight and boils 3 times, and each 2 hours, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain; The preparation method of Radix Actinidiae Chinensis Chinensis extrat is: gets the decocting that Radix Actinidiae Chinensis adds 8 times of weight and boils 3 times, and each 2 hours, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain; The preparation method of Semen Armeniacae Amarum extract is: gets the decocting that Semen Armeniacae Amarum adds 6 times of weight and boils 4 times, and each 2 hours, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain; Ganoderma extract: get the decocting that Ganoderma adds 6 times of weight and boil 3 times, each 2 hours, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
Embodiment 2: the emulsifiable paste of anti-anaphylaxis desensitization of the present invention, reparative regeneration effect
Get 20g Chinese medicine composition of the present invention, 35g glyceryl monostearate, 130g stearic acid, 50mL liquid Paraffin, 20mL azone and 20g simethicone be mixed and heated to 85 ℃ standby;
Getting 50mL glycerol, 4g Borax, 4g sodium lauryl sulphate, 3g allantoin, 1.5g ethyl hydroxybenzoate, 50mL propylene glycol and 653mL purified water mixes, be heated to 85 ℃, then add the 10mL triethanolamine to continue to be heated to 85 ℃, with the mixture of gained, mix to emulsifying, cooling, obtain.
Embodiment 3: anti-anaphylaxis desensitization clinical observation on the therapeutic effect:
Select skin of face that 110 of the women of 20～50 rubescent, as the allergic symptom such as to itch one full year of life are arranged, carry out routine examination before on probation: electrocardiogram, hematuria just conventional, hepatic and renal function are showed no extremely.110 people are divided into two groups at random.Tested group of 60 examples; Matched group 50 examples.Tested group: sooner or later after clean skin, the emulsifiable paste of the present invention of embodiment 2 preparations evenly is applied in to the rubescent place of itching, and massages gently 1～3 minute, use continuously 7 days, the trial employment period is avoided irritable food on probation, is cautious use of the zest cosmetics.Matched group: sooner or later after clean skin, smear a little PIYANPING in the rubescent place of itching, and massage gently 1～3 minute, use continuously 7 days, the trial employment period is avoided irritable food on probation, is cautious use of the zest cosmetics.Statistical result is in Table 1
Curative effect determinate standard:
Cure: check after medication that the skin rubefaction symptom of itching disappears fully, Continuous Observation not recurrence in 7 days.
Produce effects: after medication, symptom obviously alleviates.
Invalid: after medication, symptom, without alleviating, or has and increases the weight of.
Table 1 clinical observation on the therapeutic effect
In visible tested group of 60 people of the present invention of table 1 observed result, there are 54 people's allergic symptoms to disappear fully, 5 people's allergic symptoms are clearly better, and it is little that it remains 1 people's allergic symptom variation, and total effective rate reaches 98.3%, do not have an example untoward reaction to occur, the matched group total effective rate is only 12%.Result shows, Chinese medicine composition of the present invention has the effect of anti-anaphylaxis desensitization, nontoxic to human-body safety, remarkable for skin rubefaction, the irritated therapeutic effect of itching.
Embodiment 4: reparative regeneration effect clinical observation on the therapeutic effect:
Select the skin of face acne scars obviously, 110 of 15～35 patients of unsystematic disease, carry out routine examination before on probation: electrocardiogram, hematuria just conventional, hepatic and renal function are showed no extremely.110 people are divided into two groups at random.Tested group of 60 examples; Matched group 50 examples, every group of M-F is similar.Tested group: sooner or later after clean skin, the emulsifiable paste of the present invention of embodiment 2 preparations evenly is applied in to face, and massages gently 1～3 minute, use continuously 30 days.Matched group: sooner or later after clean skin, smear a little dimension E WEIFU GAO in face, and massage gently 1～3 minute, use continuously 30 days.Statistical result is in Table 1
Curative effect determinate standard:
Cure: after medication, the skin acne cicatrix is obviously desalinated, and shrink in acne depression hole.
Produce effects: skin acne cicatrix desalination after medication.
Invalid: after medication, the skin acne cicatrix is without alleviating.
Table 1 clinical observation on the therapeutic effect
In visible tested group of 60 people of the present invention of table 1 observed result, have 12 people's acne scars obviously to desalinate, shrink in acne depression hole, 43 people's acne scars desalinations, it is little that it remains 5 people's symptom variation, total effective rate reaches 91.7%, does not have an example untoward reaction to occur, and the matched group total effective rate is only 16%.And continuing to use emulsifiable paste of the present invention more than half a year, cure rate obviously increases.Result shows, Chinese medicine composition of the present invention has the effect of reparative regeneration, nontoxic to human-body safety, remarkable for skin acne treating acne effect.
The explanation of above embodiment is just for helping to understand method of the present invention and core concept thereof.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of the claims in the present invention.
Claims (8)
1. the Chinese medicine composition with anti-anaphylaxis desensitization, reparative regeneration effect, is characterized in that, by waiting following raw water of weight portion to be fried into: Herba Anemones vitifoliae extract, Radix Actinidiae Chinensis Chinensis extrat, Semen Armeniacae Amarum extract, Ganoderma extract.
2. Chinese medicine composition according to claim 1, is characterized in that, the preparation method of described Herba Anemones vitifoliae extract is: get the decocting that Herba Anemones vitifoliae adds 6-8 times of weight and boil 2-4 time, and each 1-3 hour, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
3. Chinese medicine composition according to claim 1, is characterized in that, the preparation method of described Radix Actinidiae Chinensis Chinensis extrat is: get the decocting that Radix Actinidiae Chinensis adds 6-8 times of weight and boil 2-4 time, and each 1-3 hour, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
4. Chinese medicine composition according to claim 1, is characterized in that, the preparation method of described Semen Armeniacae Amarum extract is: get the decocting that Semen Armeniacae Amarum adds 6-8 times of weight and boil 2-4 time, and each 1-3 hour, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
5. Chinese medicine composition according to claim 1, is characterized in that, the preparation method of described Ganoderma extract is: get the decocting that Ganoderma adds 6-8 times of weight and boil 2-4 time, and each 1-3 hour, merge extractive liquid,, the dry powder of beating, mistake 100 mesh sieves, obtain.
6. the emulsifiable paste that comprises the described Chinese medicine composition of claim 1～5 any one.
7. the emulsifiable paste with anti-anaphylaxis desensitization, reparative regeneration effect, is characterized in that, by following weight portion raw material, made:
Described Chinese medicine composition 20g, glyceryl monostearate 35g, stearic acid 130g, liquid Paraffin 50mL, azone 20mL, simethicone 20g, Borax 4g, allantoin 3g, glycerol 50mL, propylene glycol 50mL, ethyl hydroxybenzoate 1.5g, dodecylphosphoric acid sodium 4g, triethanolamine 10mL and the purified water 653mL with anti-anaphylaxis desensitization, reparative regeneration effect of claim 1.
8. the described preparation method with emulsifiable paste of anti-anaphylaxis desensitization, reparative regeneration effect of claim 7, is characterized in that, comprises the following steps
Step 1: get glyceryl monostearate, stearic acid, liquid Paraffin, azone and simethicone be mixed and heated to 85 ℃ standby;
Step 2: the weighting profit requires 1 describedly to have anti-anaphylaxis desensitization, the Chinese medicine composition of reparative regeneration effect, glycerol, Borax, sodium lauryl sulphate, allantoin, purified water, ethyl hydroxybenzoate, a mixed with propylene glycol, be heated to 85 ℃, then add triethanolamine to continue to be heated to 85 ℃, mix to emulsifying with step 1 mixture, cooling, obtain.
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| CN 201210080725 CN102626471B (en) | 2012-03-23 | 2012-03-23 | Traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration |
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| KR101974502B1 (en) * | 2017-10-13 | 2019-05-03 | 주식회사 코리아나화장품 | Cosmetic composition for anti-allergy and for improving atopic dermatitis comprising extract of anemone reflexa stephan as active ingredient |
| CN113940914A (en) * | 2021-10-15 | 2022-01-18 | 江苏集萃新型药物制剂技术研究所有限公司 | Transdermal ointment, drug-loaded composition and drug-loaded preparation thereof |
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| CN1139566A (en) * | 1995-06-30 | 1997-01-08 | 刘会霖 | Medicine for acne and production technology |
| CN1307898A (en) * | 2000-12-13 | 2001-08-15 | 王清纯 | Chinese medicine liniment for treating acne fast |
| CN101757056B (en) * | 2008-12-23 | 2012-05-02 | 首都医科大学 | Extract of yangtao actinidia root and preparation method and applications thereof |
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