CN102626434A - 一种从微孔草籽粕中分离纯化黄酮类化合物的制备方法 - Google Patents
一种从微孔草籽粕中分离纯化黄酮类化合物的制备方法 Download PDFInfo
- Publication number
- CN102626434A CN102626434A CN2012101219500A CN201210121950A CN102626434A CN 102626434 A CN102626434 A CN 102626434A CN 2012101219500 A CN2012101219500 A CN 2012101219500A CN 201210121950 A CN201210121950 A CN 201210121950A CN 102626434 A CN102626434 A CN 102626434A
- Authority
- CN
- China
- Prior art keywords
- temperature
- grass seed
- under
- flavone
- obtains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000025254 Cannabis sativa Species 0.000 title claims abstract description 61
- -1 flavonoid compounds Chemical class 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 20
- 229930003935 flavonoid Natural products 0.000 title abstract description 12
- 235000017173 flavonoids Nutrition 0.000 title abstract description 12
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims abstract description 66
- 229930003944 flavone Natural products 0.000 claims abstract description 66
- 235000011949 flavones Nutrition 0.000 claims abstract description 66
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims abstract description 66
- 238000000605 extraction Methods 0.000 claims abstract description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000012528 membrane Substances 0.000 claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 30
- 238000000926 separation method Methods 0.000 claims abstract description 29
- 150000002212 flavone derivatives Chemical class 0.000 claims abstract description 20
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 20
- 238000001471 micro-filtration Methods 0.000 claims abstract description 10
- 241000209094 Oryza Species 0.000 claims description 34
- 235000007164 Oryza sativa Nutrition 0.000 claims description 34
- 235000009566 rice Nutrition 0.000 claims description 34
- 230000001476 alcoholic effect Effects 0.000 claims description 27
- 239000000126 substance Substances 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 18
- 239000012466 permeate Substances 0.000 claims description 18
- 239000000919 ceramic Substances 0.000 claims description 12
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 9
- 229960004756 ethanol Drugs 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 238000010298 pulverizing process Methods 0.000 claims description 9
- 238000005516 engineering process Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000746 purification Methods 0.000 abstract description 5
- 230000006378 damage Effects 0.000 abstract description 3
- 238000000108 ultra-filtration Methods 0.000 abstract description 3
- 239000000287 crude extract Substances 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 7
- 238000004737 colorimetric analysis Methods 0.000 description 7
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 7
- 150000002215 flavonoids Chemical class 0.000 description 7
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 7
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 7
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 7
- 235000005493 rutin Nutrition 0.000 description 7
- 229960004555 rutoside Drugs 0.000 description 7
- 230000008901 benefit Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- 241001072256 Boraginaceae Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000008871 Microula Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005272 metallurgy Methods 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 230000008542 thermal sensitivity Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Extraction Or Liquid Replacement (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
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CN201210121950.0A CN102626434B (zh) | 2012-04-25 | 2012-04-25 | 一种从微孔草籽粕中分离纯化黄酮类化合物的制备方法 |
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CN201210121950.0A CN102626434B (zh) | 2012-04-25 | 2012-04-25 | 一种从微孔草籽粕中分离纯化黄酮类化合物的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN102626434A true CN102626434A (zh) | 2012-08-08 |
CN102626434B CN102626434B (zh) | 2014-02-19 |
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CN201210121950.0A Active CN102626434B (zh) | 2012-04-25 | 2012-04-25 | 一种从微孔草籽粕中分离纯化黄酮类化合物的制备方法 |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101157879A (zh) * | 2007-07-28 | 2008-04-09 | 中国科学院西北高原生物研究所 | 野生植物资源微孔草籽油的超临界co2萃取工艺 |
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2012
- 2012-04-25 CN CN201210121950.0A patent/CN102626434B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101157879A (zh) * | 2007-07-28 | 2008-04-09 | 中国科学院西北高原生物研究所 | 野生植物资源微孔草籽油的超临界co2萃取工艺 |
Non-Patent Citations (2)
Title |
---|
《食品超临界CO2流体加工技术》 20050430 张德全、胡晓丹编著 超临界CO2流体萃取分离黄酮 113-118页 1-2 , * |
张德全、胡晓丹编著: "《食品超临界CO2流体加工技术》", 30 April 2005, article "超临界CO2流体萃取分离黄酮", pages: 113 - 118 * |
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CN102626434B (zh) | 2014-02-19 |
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Owner name: LINYI SIKE BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: NORTHWEST PLATEAU-ORGANISMS RESEARCH INST. OF CHINESE ACADEMY OF SCIENCES Effective date: 20150422 |
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Effective date of registration: 20160823 Address after: 276017 Shandong city of Linyi province high tech Zone Innovation Road bimonthly building B419 Patentee after: SHANDONG RUNMU BIO-TECHNOLOGY CO.,LTD. Address before: 276000 Shandong city of Linyi province high tech Zone Innovation bimonthly road building block B room 419 Patentee before: LINYI SIKE BIOTECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20200306 Address after: Room 301, building 4, No. 778, Asia Pacific Road, Nanhu District, Jiaxing City, Zhejiang Province Patentee after: ZHEJIANG QIRUN BIOLOGICAL TECHNOLOGY Co.,Ltd. Address before: 276017 Shandong city of Linyi province high tech Zone Innovation Road bimonthly building B419 Patentee before: SHANDONG RUNMU BIO-TECHNOLOGY CO.,LTD. |
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Denomination of invention: A preparation method for separating and purifying flavonoids from microporous grass seed meal Effective date of registration: 20221103 Granted publication date: 20140219 Pledgee: Agricultural Bank of China Limited by Share Ltd. South Lake branch Pledgor: ZHEJIANG QIRUN BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2022980020741 |