CN102614284B - Oral liquid for treating malignancy and preparing method - Google Patents
Oral liquid for treating malignancy and preparing method Download PDFInfo
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Abstract
The invention discloses an oral liquid for treating malignancy and a preparing method. The oral liquid is mainly used for improving human immunity and chooses pine needles, dandelion, sweet-scented osmanthus, folium mori, Ligusticum wallichii, the root bark of shaggy-fruited dittany, thunder god vine, orange peel, semen brassicae, green plum blossom and Chinese date for preparing the oral liquid. According to clinical observation in hospital, the oral liquid has the function of enhancing immunity, invigorating blood circulation and reducing phlegm and resolving masses, has excellent curative effect on medium and later period lung cancer and liver cancer and especially can remarkably improve chemotherapy and radiotherapy effects. The oral liquid is free of toxic and side effects, convenient to take and worth of clinical promotion.
Description
Technical field
The present invention relates to a kind of Chinese medicine oral liquid, relate in particular to a kind of oral liquid and preparation method for the treatment of malignant tumor.
Background technology
Along with modern society's high speed development, various paathogenic factors are more and more, as environmental pollution, unhygienic diet, pressure is excessive, and living not, rhythm and pace of moving things etc. all will cause tumor patient more and more diversified, and present a rapidly rising trend, at present the expert is consistent thinks, operation, radiation and chemotherapy are considered to treat " three magic weapons " of tumor, solved to a certain extent really cancer at the moment with some problem of part.But its side effect is very big, and wherein the overwhelming majority can cause leukopenia.Operation and radiotherapy can only solve local problem; Chemotherapy also can not be killed all cancerous cell because being subjected to the each side condition restriction, and the injury of human heaviness is easy to form the secondary tumor.Traditional method for the treatment of mostly is " treating the poisonous disease with poisonous drugs ", though can kill and wound some cancerous cell, has also damaged a large amount of human normal tissue cells, and what is called loses more than gain.And traditional Chinese medicine cancer also mostly all is with some the medicine of severe toxicity such as Mylabris, arsenicum, Natrii Sulfas, Fructus Bruceae, Semen Strychni etc. to be arranged, if these Chinese medicines are long-term or large dose oral administration also can cause certain infringement to some internal organs of human body, and might produce accumulate poisoning.Therefore seeking new Therapeutic Method according to traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors theory very presses for.
Summary of the invention
The purpose of this invention is to provide a kind for the treatment of to improve body immunity, have enhance immunity, promoting blood circulation and detoxication, the Chinese medicine oral liquid of dissipating phlegm and resolving masses.
The objective of the invention is to be achieved through the following technical solutions, the oral liquid of this treatment malignant tumor is made by following parts by weight of Chinese traditional medicine: Folium Pini 25-35 part, Herba Taraxaci 10-20 part, Flos Osmanthi Fragrantis 15-20 part, Folium Mori 20-30 part, Rhizoma Chuanxiong 15-25 part, Cortex Dictamni 15-20 part, Radix Tripterygii Wilfordii 10-15 part, Pericarpium Citri tangerinae 15-25 part, Semen Sinapis Albae 8-12 part, FLOS MUME 8-12 part, Fructus Jujubae 15-25 part.
Preferably, the oral liquid of this treatment malignant tumor is made by following parts by weight of Chinese traditional medicine: 30 parts in Folium Pini, 15 parts of Herba Taraxacis, 17 parts of Flos Osmanthi Fragrantis, 25 parts on Folium Mori, 20 parts of Rhizoma Chuanxiongs, 17 parts of Cortex Dictamni, 20 parts of 12 parts of Pericarpium Citri tangerinaes of Radix Tripterygii Wilfordii, 10 parts of Semen Sinapis Albaes, 10 parts of FLOS MUME, 20 parts in Fructus Jujubae.
The preparation method of this oral liquid is: take by weighing above Chinese crude drug Folium Pini 300g in proportion, Rhizoma Chuanxiong 200g, Cortex Dictamni 170g, Radix Tripterygii Wilfordii 120g, Pericarpium Citri tangerinae 200g, Semen Sinapis Albae 100g, FLOS MUME 100g, Fructus Jujubae 200g, decoct with water three times, 1.5 hours for the first time, second, three times each 1 hour, collecting decoction filtered, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 70 ℃ regulates pH value to 1.0～1.5 in right amount, be incubated 1 hour, left standstill 10 hours, filter, precipitation adds 6～8 times of water gagings, regulate pH value to 7.0 with 40% sodium hydroxide solution, add equivalent ethanol again, stir and make dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 70 ℃ are incubated 30 minutes, left standstill 10 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol, obtains extract A; Herba Taraxaci 150g, Flos Osmanthi Fragrantis 170g, after Folium Mori 250g adds water temperature and soaks half an hour, decoct secondary, each 1 hour, collecting decoction filters, and it is 1.20～1.25 (60～70 ℃ of surveys) that filtrate is concentrated into sweet relatively degree, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 10 hours, filter, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add extract A, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stirs evenly, cold preservation (4～8 ℃) 72 hours filters, and filtrate adds sucrose 300g, stirring makes dissolving, adds essence more in right amount and regulates pH value to 7.0, adds water and makes 1100ml, stir evenly, left standstill 10 hours, and filtered fill, sterilization, namely.
In the side: Folium Pini expelling wind and activating blood circulation, the detoxifcation of calming the nerves; The Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG; The Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; The broken knot of Flos Osmanthi Fragrantis cold expelling, preventing phlegm from forming and stopping coughing; The Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; During Pericarpium Citri tangerinae is regulated the flow of vital energy and is transferred, drying dampness to eliminate phlegm; The Radix Tripterygii Wilfordii detoxifcation of dispeling the wind; Semen Sinapis Albae warming the lung eliminating phlegm promoting the circulation of QI, the resolving mass and removing the obstruction of the collateral pain relieving; FLOS MUME soothing liver-QI stomach function regulating reduces phlegm; The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be rich in antioxidation, defying age material pine needle flavone in the Folium Pini, this material has unique water solublity, the contained unsaturated fatty acid of energy and Folium Pini sees through blood vessel wall and enters blood, fat and cholesterol in the dissolving blood vessel, by increasing bile secretion, reduce the accumulation of cholesterol, thereby prevention of arterial hardens, improves erythrocytic oxygen carrying capacity, blood circulation promoting.The selenium element that contains in the Folium Pini is consistent anticancer element of generally acknowledging in the world, is described as " anticancer king ".Folium Mori can prevent cancerous cell to generate, and improve body immunity, and the major function composition is DNJ, flavonoid, Sang Su, γ-An Jidingsuan and vitamin, can suppress chromosome mutation and gene mutation.
Clinical data
To coming the tumor patient of my institute's treatment, we have done clinical observation, to 185 routine pulmonary carcinoma, in the summary of hepatocarcinoma patient with oral liquid treatment of the present invention, III phase and IV phase patient account for 90% in the 132 routine pulmonary carcinoma, are 29.5% with the effective percentage of oral liquid treatment of the present invention.Under the same terms, the efficient that chemotherapy group (VCR+CTX+5F U) has is 13.4%, and it is 46.2% that chemotherapy adds the effective percentage of taking oral liquid of the present invention, raising evident in efficacy; The radiotherapy effective percentage is 30.7%, and radiotherapy adds the effective percentage of taking oral liquid treatment of the present invention and reaches 58.3%.In 53 routine hepatocarcinoma, in, patients with terminal accounts for 96.2%, is 70.3% with the effective percentage of oral liquid treatment of the present invention, the effective percentage of chemotherapy group (MMC+5FU) is 12.5%, it is 56.2% that chemotherapy adds oral liquid effective percentage of the present invention, than simple chemotherapy significant effective.112 routine late malignant tumours are treated by my institute, wherein 72 examples routinely chemotherapy, radiotherapy add oral liquid of the present invention, treatment finishes back 1 month, stable curative effect does not have new focus and occurs.Illustrate that this medicine cooperates with chemotherapy, radiotherapy, respond well, played the obvious synergistic antitumaous effect; Though in addition 40 routine late malignant tumour patients have lost the chance of operation and chemotherapy, radiotherapy, add Comprehensive Treatment with oral liquid of the present invention, produce effects adds totally 21 examples effectively, total effective rate 52.5% as a result.Simultaneously patient's subjective symptoms, abdominal distention tight as cough, gas, pain etc. all obviously alleviate, and appetite takes a turn for the better, and immunologic function strengthens.
Simultaneously, in clinical observation, do not find significant side effects.
The specific embodiment
Embodiment: take by weighing above Chinese crude drug Folium Pini 300g in proportion, Rhizoma Chuanxiong 200g, Cortex Dictamni 170g, Radix Tripterygii Wilfordii 120g, Pericarpium Citri tangerinae 200g, Semen Sinapis Albae 100g, FLOS MUME 100g, Fructus Jujubae 200g, decoct with water three times, 1.5 hours for the first time, second, three times each 1 hour, collecting decoction filtered, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 70 ℃ regulates pH value to 1.0～1.5 in right amount, be incubated 1 hour, left standstill 10 hours, filter, precipitation adds 6～8 times of water gagings, regulate pH value to 7.0 with 40% sodium hydroxide solution, add equivalent ethanol again, stir and make dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 70 ℃ are incubated 30 minutes, left standstill 10 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol, obtains extract A; Herba Taraxaci 150g, Flos Osmanthi Fragrantis 170g, after Folium Mori 250g adds water temperature and soaks half an hour, decoct secondary, each 1 hour, collecting decoction filters, and it is 1.20～1.25 (60～70 ℃ of surveys) that filtrate is concentrated into sweet relatively degree, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 10 hours, filter, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add extract A, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stirs evenly, cold preservation (4～8 ℃) 72 hours filters, and filtrate adds sucrose 300g, stirring makes dissolving, adds essence more in right amount and regulates pH value to 7.0, adds water and makes 1100ml, stir evenly, left standstill 10 hours, and filtered fill, sterilization, namely.
Claims (2)
1. an oral liquid for the treatment of malignant tumor is characterized in that the oral liquid of this treatment malignant tumor is made by following parts by weight of Chinese traditional medicine: Folium Pini 25-35 part, Herba Taraxaci 10-20 part, Flos Osmanthi Fragrantis 15-20 part, Folium Mori 20-30 part, Rhizoma Chuanxiong 15-25 part, Cortex Dictamni 15-20 part, Radix Tripterygii Wilfordii 10-15 part, Pericarpium Citri tangerinae 15-25 part, Semen Sinapis Albae 8-12 part, FLOS MUME 8-12 part, Fructus Jujubae 15-25 part.
2. preparation method for the treatment of the oral liquid of malignant tumor, it is characterized in that: take by weighing Chinese crude drug Folium Pini 300g in proportion, Rhizoma Chuanxiong 200g, Cortex Dictamni 170g, Radix Tripterygii Wilfordii 120g, Pericarpium Citri tangerinae 200g, Semen Sinapis Albae 100g, FLOS MUME 100g, Fructus Jujubae 200g, decoct with water three times, 1.5 hours for the first time, second, three times each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 70 ℃ regulates pH value to 1.0～1.5 in right amount, is incubated 1 hour, left standstill 10 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, add equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 70 ℃ are incubated 30 minutes, left standstill 10 hours, and filtered, precipitation is washed till pH value 7.0 with ethanol, it is standby to wave most ethanol, obtains extract A; Herba Taraxaci 150g, Flos Osmanthi Fragrantis 170g, after Folium Mori 250g adds water temperature and soaks half an hour, decoct secondary, each 1 hour, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into 60～70 ℃ of relative densities of measuring down, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 10 hours, filter, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add extract A, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stirs evenly, 4～8 ℃ of following cold preservations 72 hours, filter, filtrate adds sucrose 300g, stirring makes dissolving, adds essence more in right amount and regulates pH value to 7.0, adds water and makes 1100ml, stir evenly, left standstill 10 hours, and filtered fill, sterilization, namely.
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| KR100583051B1 (en) * | 2003-12-31 | 2006-05-24 | 한국생명공학연구원 | Extracts of cinnamon and zizyphus zuzuba for the prevention and treatment of cancers |
| CN1311862C (en) * | 2004-09-03 | 2007-04-25 | 曾隆江 | Medicine for treating cancer |
| US20060269567A1 (en) * | 2005-05-16 | 2006-11-30 | Liu Yuen | Universal detoxifying composition |
| US20070248619A1 (en) * | 2006-04-21 | 2007-10-25 | Chang Cabezas Jorge P | New pharmaceutical composition from natural materials for regulating immunity, its preparation method and use |
| CN101073663A (en) * | 2007-02-16 | 2007-11-21 | 中山大学 | Chinese-medicinal composition for treating malignant tumor and its production |
| WO2009066712A1 (en) * | 2007-11-21 | 2009-05-28 | Kracie Pharma, Ltd. | Aromatase inhibitor |
| CN101670056B (en) * | 2008-09-10 | 2011-08-03 | 吴昆仑 | Medicament for treating malignant tumor |
| KR20100043882A (en) * | 2008-10-21 | 2010-04-29 | 김정환 | Extract of mulberry leaves having inhibition activity for helicobacter pylori, method for preparing the same and the healthfunctional food using thereof |
| CN101543616B (en) * | 2009-04-21 | 2012-07-04 | 闫树清 | Traditional Chinese medicine composition for preventing and treating tumor and its preparation method |
| CN102048805A (en) * | 2009-11-05 | 2011-05-11 | 天津太平洋制药有限公司 | Chinese medicinal preparation for treating malignant tumor and preparation method thereof |
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