CN102614264A - Medicine for treating eyelid spasm - Google Patents

Abstract

The invention relates to medicament, in particular to a medicine prepared from Chinese medicinal materials serving as raw materials and used for treating eyelid spasm. The medicament consists of centipede, Chinese angelica, szechuan lovage rhizome, white paeony root, red paeony root, leech, scorpio, typhonium giganteum, stiff silkworm, Chinese ephedra, dahurian angelica root, astragalus, divaricate saposhnikovia root and earthworm. A method for preparing the medicament comprises the following the steps of: uniformly mixing the medicinal materials according to parts by weight; smashing into medicinal powder of 100-120 meshes; and sterilizing, disinfecting, and preparing a water pill product by using a bonding agent according the conventional method. The medicament provided by the invention has the effects of promoting blood circulation, promoting qi circulation, removing obstruction in the collateral, nourishing blood and liver, relieving pain, expelling wind-dampness, activating blood, expelling pus, promoting tissue regeneration and relieving pain, and has the advantages of treatment of both principal and secondary aspects of eyelid spasm, definite curative effect, no toxic or side effect or anaphylactic reaction, high curative rate, no side effects of other western medicinal preparations on liver and kidney injuries and the like, no medicament resistance of business antibiotics and the like, and easiness for a patient to accept.

Description

A kind of medicine of treating blepharospasm

Technical field

The present invention relates to a kind of medicine, being specially a kind of is the medicine of the treatment blepharospasm of feedstock production with the Chinese crude drug.

Background technology

Blepharospasm means the spontaneous spastic contraction of all orbicular muscle of eye, socket of the eye and socket of the eye.Being mainly in middle-aged and elderly people, is one of common disease of ophthalmology, brings great misery through the audit health for the patient, also extremely influences attractive in appearance.It does not have the clonicity of lower face muscle to twitch.It is changeable to continue the spasm time, spasm show as the continuous repetition that non-will property is closed one's eyes strongly.Many blepharospasm patients are obtaining having stood the misery of long duration before clear and definite diagnosis and the treatment, and have often delayed timely treatment because of mistaken diagnosis.

China develops A type meat poison crystalline toxin in the nineties, and is applied to clinical.Through zoopery and clinical and experimental study, quality, purity and effect of drugs all reach external similar drug level.Botulinum toxin mainly acts on the cholinoceptor of teleneuron, and antagonism Ca combines with cholinoceptor.Suppress the release of acetylcholine, thereby muscle can't be shunk from teleneuron.

The advantage of creotoxin treatment: ⑴ instant effect, total treatment effective percentage are high.⑵ relatively have simple and easy to do, little, the few side effects of damage with operation.⑶ expense is low, is prone to be accepted by patient, and patient is ready repetitive therapy.

The shortcoming of creotoxin treatment: the ⑴ relapse rate is high.⑵ need treatment periodically repeatedly.⑶ be prone to cause local serial side reaction: the ptosis, diplopia, xerophthalmia and exposure keratitis etc.⑷ the treatment of creotoxin can only be a kind of expectant treatment of temporary relief of symptoms, but not the essence treatment.

Botulinum toxin causes owing to toxin acts on cranial nerve nuclei and peripheral nervous neuromuscular junction place and vegetative nerve tip after intestinal absorption people's toxic action.Be generally several hours to a couple of days incubation period after the botulism, and the symptom of cranial nerve palsy is arranged earlier, like headache, dizziness.Eye symptom appears then: because the platycoria that the inner and external flesh of eyes paralysis causes is regulated infringement, blepharoptosis, diplopia, blurred vision etc.Pharyngeal neural paralysis can have dysphagia, chew insensitive, hoarseness, aphasis.Cause dyspnea at a distance from myoparalysis, the difficulty that comes back, ataxia; Limb paralysis etc.Patient dies from dyspnea and heart failure more.

Summary of the invention

To the deficiency of prior art, the purpose of this invention is to provide a kind of medicine of treating blepharospasm, this medicine is short medicine time, makes things convenient for medication, and cure rate is high, and relapse rate is low.

Medicine of the present invention is that raw material makes by following parts by weight of traditional Chinese medicines:

Scolopendra 3-6 Radix Angelicae Sinensis 9-12

Rhizoma Chuanxiong 12-15 Radix Paeoniae Albas 10-12

Radix Paeoniae Rubra 12-15 Hirudos 10-12

Scorpio 6-9 Herba Typhonii gigantei 9-13

Bombyx Batryticatus 6-9 Herba Ephedraes 3-5

The Radix Angelicae Dahuricae 6-9 Radixs Astragali 15-20

Windproof 6-9 Pheretimas 8-12.

The medicine of above-mentioned each component can be processed said peroral dosage form on any pharmaceuticss such as tablet, pill, powder, capsule, and the preferred dosage form of the present invention is a water pill.

The concrete method for preparing of medicine water pill of the present invention agent is: said medicine by said parts by weight mix homogeneously, is ground into 100～120 purpose medicated powder, and sterilization uses binding agent to make the water pill product by conventional method.

Blepharospasm is that senile brain stem degeneration causes or is due to the neural discomfort of face.The traditional Chinese medical science is claimed " eyelid twitch ", and the traditional Chinese medical science is thought liver, temper blood discord, gives birth in the incoordination between nutrient QI and defensive QI wind-fire, and muscle is become homeless and supported and cause a face muscles tramp.

In the prescription of the present invention, that Scolopendra relieves internal heat is anticancer, relieving spasm by calming endogenous wind, move back inflammation and control skin ulcer; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; The Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping; The Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant; Radix Paeoniae Rubra clots absorbing, pain relieving, removing heat from blood, detumescence; Diseases such as Hirudo menstruation apolipsis, lump in the abdomen stomachache, blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas; Scorpio endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; The Herba Typhonii gigantei drying dampness to eliminate phlegm is expellingged wind and relieving convulsion, the detoxicating and resolving stagnation of pathogens pain relieving; The Bombyx Batryticatus expelling wind for relieving convulsion, dissipating phlegm and resolving masses; Herba Ephedrae diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; Radix Angelicae Dahuricae wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving; Radix Astragali benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly; Windproof expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion is jerked surely; The Pheretima heat clearing away, spasmolytic, diuresis, detoxifcation.More than all medicines share blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, nourishing blood to suppress the hyperactive liver, slow in pain relieving, wind-damp dispelling, the evacuation of pus of invigorating blood circulation, the merit of granulation promoting pain relieving.The treatment treating both the principal and secondary aspects of a disease that is used for blepharospasm, determined curative effect has no side effect and anaphylaxis, and cure rate is high, does not have other Western medicine prepns to side reactions such as liver, renal damages, and the drug resistance of professional antibiotic etc. is easy to the patient and accepts.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 150 routine blepharospasm patients that the curative effect of medicine of the present invention is carried out clinical observation.

150 routine cases are divided into two groups at random, and 76 examples are organized in treatment, matched group 74 examples.

The treatment group: use medicine of the present invention, each 20, every day three times, warm water takes.Matched group: Carbamazepine Tablets (ShangHai Fudan Fuhua Pharmaceutical Co., Ltd's production), the each 100～200mg of predose, increases dosage until optimum curative effect gradually at every day 1～2 time.

Press blepharospasm strength grading assessments such as Cohen:

0 grade: no spasm;

The I level: outside stimulus causes to twinkle and increases:

The II level: slight, the eyelid facial muscle slightly trembles, no dysfunction;

The III level: moderate, spasm is obvious, and slight dysfunction is arranged;

The IV level: severe, serious spasm and dysfunction influence work and life.

The criterion of therapeutical effect evaluation:

1. alleviate fully: III～IV level is reduced to 0 grade;

2. obviously alleviate: the spasm classification descends >=2 grades;

3. part is alleviated: spasm classification decline I level;

4. invalid: the spasm classification does not have reduction.

Two groups of case treatment back curative effect comparative results are seen table 1.

Table 1 liang group case treatment back curative effect relatively

Group

The example number

Alleviate n (%) fully

Obviously alleviate n (%)

Part is alleviated n (%)

Invalid n (%)

Total effective rate n (%)

Matched group

74

36（48.6）

18（24.3）

5（6.8）

15（20.3）

59（79.7）

The treatment group

76

58（76.3）

13（17.1）

3（3.9）

2（3.4）

74（97.4）

Clinical experiment is the result prove, drug effect of the present invention obviously is superior to matched group, do not see any untoward reaction.

The specific embodiment

Embodiment 1

Get Scolopendra 6kg, Radix Angelicae Sinensis 12 kg, Rhizoma Chuanxiong 15 kg, the Radix Paeoniae Alba 12 kg, Radix Paeoniae Rubra 15 kg; Hirudo 12 kg, Scorpio 9 kg, Herba Typhonii gigantei 13 kg, Bombyx Batryticatus 9 kg; Herba Ephedrae 5 kg, the Radix Angelicae Dahuricae 9 kg, the Radix Astragali 20 kg, windproof 9 kg; Pheretima 12 kg by said parts by weight mix homogeneously, are ground into 100～120 purpose medicated powder with said medicine, and sterilization uses binding agent to make the water pill product by conventional method.

Embodiment 2

Get Scolopendra 3kg, Radix Angelicae Sinensis 9kg, Rhizoma Chuanxiong 12 kg, Radix Paeoniae Alba 10kg, Radix Paeoniae Rubra 12kg; Hirudo 10kg, Scorpio 6kg, Herba Typhonii gigantei 9kg, Bombyx Batryticatus 6kg; Herba Ephedrae 3kg, Radix Angelicae Dahuricae 6kg, Radix Astragali 15kg, windproof 6kg; Pheretima 8kg by said parts by weight mix homogeneously, is ground into 100～120 purpose medicated powder with said medicine, and sterilization uses binding agent to make the water pill product by conventional method.

Claims (1)

1. medicine of treating blepharospasm is that raw material makes by following parts by weight of traditional Chinese medicines:

Scolopendra 3-6 Radix Angelicae Sinensis 9-12

Rhizoma Chuanxiong 12-15 Radix Paeoniae Albas 10-12

Radix Paeoniae Rubra 12-15 Hirudos 10-12

Scorpio 6-9 Herba Typhonii gigantei 9-13

Bombyx Batryticatus 6-9 Herba Ephedraes 3-5

The Radix Angelicae Dahuricae 6-9 Radixs Astragali 15-20

Windproof 6-9 Pheretimas 8-12.