CN102608255A - 一种鹤草酚薄层鉴别方法 - Google Patents
一种鹤草酚薄层鉴别方法 Download PDFInfo
- Publication number
- CN102608255A CN102608255A CN2012100655860A CN201210065586A CN102608255A CN 102608255 A CN102608255 A CN 102608255A CN 2012100655860 A CN2012100655860 A CN 2012100655860A CN 201210065586 A CN201210065586 A CN 201210065586A CN 102608255 A CN102608255 A CN 102608255A
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- agrimophol
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- medicinal material
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- NQGCBDWQKDAGTK-RYZVSIALSA-N Agrimophol Chemical compound CC1=C(OC)C(C(=O)CCC)=C(O)C(C[C@]2(C)C(C(C(=O)[C@H](C)CC)=C(O)C(C)=C2O)=O)=C1O NQGCBDWQKDAGTK-RYZVSIALSA-N 0.000 title claims abstract description 31
- NQGCBDWQKDAGTK-QDXKXIGTSA-N Agrimophol Natural products O=C(CCC)c1c(OC)c(C)c(O)c(C[C@]2(C)C(=O)C(C(=O)[C@H](CC)C)=C(O)C(C)=C2O)c1O NQGCBDWQKDAGTK-QDXKXIGTSA-N 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims abstract description 27
- 238000004809 thin layer chromatography Methods 0.000 title abstract description 4
- WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 claims abstract description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 244000307697 Agrimonia eupatoria Species 0.000 claims description 26
- 235000000125 common agrimony Nutrition 0.000 claims description 26
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 239000000741 silica gel Substances 0.000 claims description 15
- 229910002027 silica gel Inorganic materials 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 241000750328 Agrimonia nipponica Species 0.000 claims description 3
- 235000005653 Agrimonia nipponica Nutrition 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims 2
- 239000003607 modifier Substances 0.000 claims 1
- 238000005220 pharmaceutical analysis Methods 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 description 45
- 239000013558 reference substance Substances 0.000 description 44
- 238000012360 testing method Methods 0.000 description 42
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 24
- 238000004587 chromatography analysis Methods 0.000 description 13
- 239000000284 extract Substances 0.000 description 12
- 238000005406 washing Methods 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 238000000605 extraction Methods 0.000 description 6
- 238000010992 reflux Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 241000208340 Araliaceae Species 0.000 description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 description 4
- 235000008434 ginseng Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000012850 discrimination method Methods 0.000 description 2
- 229930183370 Agrimol Natural products 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000078 anti-malarial effect Effects 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- QCDYQQDYXPDABM-UHFFFAOYSA-N phloroglucinol Chemical class OC1=CC(O)=CC(O)=C1 QCDYQQDYXPDABM-UHFFFAOYSA-N 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210065586.0A CN102608255B (zh) | 2012-03-14 | 2012-03-14 | 一种鹤草酚薄层鉴别方法 |
Applications Claiming Priority (1)
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CN201210065586.0A CN102608255B (zh) | 2012-03-14 | 2012-03-14 | 一种鹤草酚薄层鉴别方法 |
Publications (2)
Publication Number | Publication Date |
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CN102608255A true CN102608255A (zh) | 2012-07-25 |
CN102608255B CN102608255B (zh) | 2015-12-02 |
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CN201210065586.0A Expired - Fee Related CN102608255B (zh) | 2012-03-14 | 2012-03-14 | 一种鹤草酚薄层鉴别方法 |
Country Status (1)
Country | Link |
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CN (1) | CN102608255B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107764927A (zh) * | 2017-10-24 | 2018-03-06 | 广州智妥科技有限公司 | 一种小叶莲的测定方法 |
CN112763618A (zh) * | 2020-12-29 | 2021-05-07 | 四川新绿色药业科技发展有限公司 | 一种仙鹤草配方颗粒特征图谱鉴别方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007094312A1 (ja) * | 2006-02-14 | 2007-08-23 | Fancl Corporation | ビタミンcトランスポーター産生促進剤 |
CN102311330A (zh) * | 2011-07-05 | 2012-01-11 | 南京泽朗农业发展有限公司 | 一种从仙鹤草中提取鹤草酚的方法 |
CN102329206A (zh) * | 2011-07-26 | 2012-01-25 | 苏州宝泽堂医药科技有限公司 | 一种鹤草酚的制备方法 |
-
2012
- 2012-03-14 CN CN201210065586.0A patent/CN102608255B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007094312A1 (ja) * | 2006-02-14 | 2007-08-23 | Fancl Corporation | ビタミンcトランスポーター産生促進剤 |
CN102311330A (zh) * | 2011-07-05 | 2012-01-11 | 南京泽朗农业发展有限公司 | 一种从仙鹤草中提取鹤草酚的方法 |
CN102329206A (zh) * | 2011-07-26 | 2012-01-25 | 苏州宝泽堂医药科技有限公司 | 一种鹤草酚的制备方法 |
Non-Patent Citations (6)
Title |
---|
KAUL MK: "High altitude botanicals in integrative medicine-Case studies from Northwest Himalaya", 《INDIAN JOURNAL IF TRADITIONAL KNOWLEDGE》 * |
上海药物研究所 等: "仙鹤草有效成分的研究", 《化学学报》 * |
潘娅 等: "仙鹤草中黄酮类化学成分研究", 《中国中药杂志》 * |
盖元珠 等: "仙鹤草有效成分的研究", 《化学学报》, vol. 36, no. 1, 31 May 1978 (1978-05-31), pages 143 - 138 * |
陈仲良 等: "仙鹤草有效成分的研究", 《化学学报》, vol. 36, no. 1, 28 February 1978 (1978-02-28), pages 36 - 48 * |
陈晓辉 等: "RP—HPLC法测定鹤草芽栓中鹤草酚的含量", 《中草药》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107764927A (zh) * | 2017-10-24 | 2018-03-06 | 广州智妥科技有限公司 | 一种小叶莲的测定方法 |
CN112763618A (zh) * | 2020-12-29 | 2021-05-07 | 四川新绿色药业科技发展有限公司 | 一种仙鹤草配方颗粒特征图谱鉴别方法 |
CN112763618B (zh) * | 2020-12-29 | 2022-03-01 | 四川新绿色药业科技发展有限公司 | 一种仙鹤草配方颗粒特征图谱鉴别方法 |
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Publication number | Publication date |
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CN102608255B (zh) | 2015-12-02 |
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Effective date of registration: 20200407 Address after: No. 34, No. 34, yanggongjing, Qinhuai District, Nanjing, Jiangsu 210002 Patentee after: Qinhuai medical area, General Hospital of the eastern theater of the Chinese PLA Address before: Yang Gong Jing Baixia District of Nanjing city in Jiangsu province 210002 34 Standard No. 34 Bayi hospital pharmacy Co-patentee before: Lan Xiaohong Patentee before: Zhou Yonggang Co-patentee before: Wei Wei |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151202 |