CN1026067C - Electrode for electrochemical therapy of esophageal cancer - Google Patents
Electrode for electrochemical therapy of esophageal cancer Download PDFInfo
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- CN1026067C CN1026067C CN 92113243 CN92113243A CN1026067C CN 1026067 C CN1026067 C CN 1026067C CN 92113243 CN92113243 CN 92113243 CN 92113243 A CN92113243 A CN 92113243A CN 1026067 C CN1026067 C CN 1026067C
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- 206010030155 Oesophageal carcinoma Diseases 0.000 title claims abstract description 14
- 208000000461 Esophageal Neoplasms Diseases 0.000 title abstract description 3
- 201000004101 esophageal cancer Diseases 0.000 title abstract description 3
- 238000002560 therapeutic procedure Methods 0.000 title abstract description 3
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 29
- 239000011810 insulating material Substances 0.000 claims abstract description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 18
- 208000017897 Carcinoma of esophagus Diseases 0.000 claims description 12
- 201000005619 esophageal carcinoma Diseases 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 11
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- 229910052697 platinum Inorganic materials 0.000 claims description 9
- 238000009413 insulation Methods 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 239000004020 conductor Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- PXXKQOPKNFECSZ-UHFFFAOYSA-N platinum rhodium Chemical compound [Rh].[Pt] PXXKQOPKNFECSZ-UHFFFAOYSA-N 0.000 claims description 5
- -1 polyethylene Polymers 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 229920002379 silicone rubber Polymers 0.000 claims description 5
- 239000004945 silicone rubber Substances 0.000 claims description 5
- 210000002784 stomach Anatomy 0.000 claims description 5
- 229920002554 vinyl polymer Polymers 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 3
- 238000004804 winding Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 210000003238 esophagus Anatomy 0.000 description 7
- 208000025865 Ulcer Diseases 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
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- 229910045601 alloy Inorganic materials 0.000 description 3
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- 239000010935 stainless steel Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses an electrode for electrochemical therapy of esophageal cancer. The present invention relates to a method for electrochemical treatment of tumor, and is characterized by that the therapeutic electrode is made up by using electrode wire and winding, its supporting body is made up by using flexible insulating material, its front end surface is equipped with end therapeutic electrode, and on the supporting body surface close to the end electrode at least one body therapeutic electrode is set, and the end electrode and body electrode are respectively connected with respective leads in axial cavity tube.
Description
The present invention relates to medical apparatus, be specifically related to a kind of electrode of the electrochemotherapy esophageal carcinoma.
Electrochemical treatment of tumors has been acknowledged as a kind of efficient ways.Disclose a kind of straight shape needle electrode among the prior art CN89207791, it has all obtained curative effect preferably to treatment tumor, breast carcinoma, pulmonary carcinoma, malignant melanoma etc.But kind electrode can not be used for the treatment of the cancer at tubulose position, for example esophageal carcinoma.Prior art CN90103428.2 has provided a kind of tubular pole of being made up of flexible pipe, electrode and central conductor for the treatment of the esophageal carcinoma, and the treatment surface area of kind electrode only limits to the surface area of one, two one metal wires, and therapeutic effect is undesirable.
The objective of the invention is to design a kind of simple in structure, the treatment area is big, good effect, be applicable to the electrode of the electrochemotherapy esophageal carcinoma.
Electrode of the present invention comprises what flexible insulating material was made, inside has the electrode of axial lumen and is arranged on the therapeutic electrode on electrode support surface, contact conductor in therapeutic electrode and the support axial lumen links, lead-in wire is drawn from the rear end of axial lumen, it is characterized in that said therapeutic electrode is made up of the body electrode that the termination electrode that is arranged on electrode support front end and at least one are arranged on electrode support surface, therapeutic electrode adopts wire electrode to be entwined, one end of termination electrode wire electrode is fixed on the support, the radial hole of the other end on support enters axial lumen and lead-in wire links, one end of body electrode is fixed on the support, the radial hole of the other end on support enters axial lumen and lead-in wire links, said support axial lumen comprises that at least is positioned at a support center, from the cavity that the support front end leads to the rear end, the part of wire electrode in axial lumen, lead-in wire all has insulated sleeve.
The electrode that the present invention provides can be deep in the esophagus and go by nasal cavity, oral cavity, termination electrode, body electrode directly contact with focus, said have a better therapeutic effect, to diseased region at cervical part of esophagus, breast epimere, section, the medullary of breast hypomere esophagus, ulcer type, constrictive type, ulcer narrowing the esophageal carcinoma all have curative effect preferably in the heart.Patients all behind the electrochemotherapy all can take food, and have improved patient's animation significantly, make some harm patients remove the hardship of intravenous nutrition, have prolonged life.That the present invention has is simple in structure, easy to use, the therapeutic electrode surface area big, good effect, be suitable for advantages such as disease is wide.
The present invention has following accompanying drawing:
Fig. 1 list chamber two-level structure sketch map
Fig. 2 list chamber three-stage structure sketch map
Fig. 3 list chamber multi-polar structure sketch map
Fig. 4 two chamber two-level structure sketch maps
Fig. 5 two chamber three-stage structure sketch maps
Fig. 6 two chamber three-stage structure sketch maps
Fig. 7 two chamber multi-polar structure sketch maps
Fig. 8 two chamber multi-polar structure sketch maps
Fig. 9 three chamber two-level structure sketch maps
Figure 10 three chamber three-stage structure sketch maps
Figure 11 three chamber multi-polar structure sketch maps
Figure 12 electrode structure sketch map that clears the way
Figure 13 fluid injection cavity configuration sketch map
Practical electrode structure sketch map of Figure 14
Practical electrode profile sketch map of Figure 15
Below in conjunction with accompanying drawing the present invention is elaborated.
According to design philosophy of the present invention,, can produce the electrochemotherapy esophageal carcinoma electrode of seriation according to the needs of clinical treatment.Design concept of the present invention is to adopt flexible material as electrode support 1, is beneficial to insert esophagus by oral cavity or nasal cavity and arrives focus; In order to obtain curative effect preferably, the present invention has adopted the design of fit electrode, is about to therapeutic electrode and is arranged on the surface (comprising end surfaces and surface) of electrode support 1, is entwined by wire electrode, can press close to focus like this, the contact of formation face; The lead-in wire 2,3 that electrode and power supply link is drawn from the support rear end through the interior lumen of support 1.This design compared with prior art, its surface area is much bigger, has kept elongated shape, flexible characteristics again, is specially adapted to treat the cancer in the narrow and long tube chamber, as the esophageal carcinoma, rectal cancer, carcinoma of prostate etc.
Accompanying drawing 1 has provided the electrode of a kind of single chamber two-level structure, its electrode support 1 has an axial lumen, its front end surface is provided with an end therapeutic electrode 5, support surface near termination electrode 5 is provided with an individual electrode 9, said axial lumen is one and is positioned at support 1 center, lead to the tube chamber 11 of rear end from the support front end, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is an electrode 9, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters central lumen 11, link with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 11, one end of body electrode 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters central lumen 11 and links with lead-in wire 3, lead-in wire 3 is drawn the part of wire electrode in tube chamber 11 through tube chamber 11 from the support rear end, lead-in wire 2,3 all have insulated sleeve.
What accompanying drawing 2 provided is single chamber three-stage structure sketch map, its axial lumen is one and is positioned at support 1 center, lead to the tube chamber 11 of rear end from the support front end, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is two electrodes 9,10, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters central lumen 11, pass from another radial hole 14 then and twine adult electrode 10, the other end of body electrode 10 enters central lumen 11 through radial hole 16, link with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 11, one end of body electrode 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters central lumen 11 and links with lead-in wire 3, lead-in wire 3 is drawn the part of wire electrode in tube chamber 11 through tube chamber 11 from the support rear end, lead-in wire 2,3 all have insulated sleeve.
Accompanying drawing 3 has provided the electrode of a kind of single chamber multi-polar structure, its therapeutic electrode is divided into two groups, link at interval, termination electrode 5 and body electrode 10 are one group, body electrode 9 is one group, its axial lumen is one and is positioned at support 1 center, lead to the tube chamber 11 of rear end from the support front end, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is plural, the electrode group 9 that the interval links, 10, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters central lumen 11, pass from another radial hole 14 then and twine adult electrode group 10, the other end of body electrode group 10 enters central lumen 11 through radial hole 16, link with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 11, one end of body electrode group 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters central lumen 11, pass from another radial hole 15 then, be wound in next individual electrode 9, organizator electrode group 9, the other end of body electrode group 9 enters central lumen 11 through radial hole 13 and links with lead-in wire 3, lead-in wire 3 is drawn the part of wire electrode in tube chamber 11 through tube chamber 11 from the support rear end, lead-in wire 2,3 all have insulated sleeve.
First three axial lumen 11 of planting in embodiment can be a cavity from the support front end to the rear end, with clear the way electrode (referring to Figure 12) and to the focus fluid injection of insertion; Also can be that front end is obstructed, logical tube chamber outside the rear end, draw from the rear end for lead-in wire 2,3.In order to reduce resistance when treatment is inserted, the front end of support 1 can be designed to hemispherical or taper shape, and for easy to operate, its rear end can have handle, is beneficial to insert, extract.
Insertion for the electrode that helps clearing the way, extract, make things convenient for fluid injection, accompanying drawing 4 has provided a kind of design of two chamber two-level structures, it is characterized in that said axial lumen has two, one is to be positioned at support 1 center, lead to the tube chamber 11 of rear end from the support front end, another is the tube chamber 19 that is positioned at support 1 axis one side, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is an electrode 9, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters tube chamber 19,2 link with lead-in wire, lead-in wire 2 is drawn from the support rear end through tube chamber 19, and an end of body electrode 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters central lumen 11 and links with lead-in wire 3, and lead-in wire 3 is drawn from the support rear end through tube chamber 11.
Accompanying drawing 5 provides the design of a kind of two chambeies three utmost points, it is characterized in that said axial lumen has two, one is to be positioned at support 1 center, lead to the tube chamber 11 of rear end from the support front end, another is the tube chamber 19 that is positioned at support 1 axis one side, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is two electrodes 9,10, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters tube chamber 19, pass from another radial hole 14 then and twine adult electrode 10, the other end of body electrode 10 enters tube chamber 19 from radial hole 16 and links with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 19, one end of body electrode 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters tube chamber 11,3 link with lead-in wire, lead-in wire 3 is drawn from the support rear end through tube chamber 11.
The design of accompanying drawing 6 is identical with the cardinal principle of accompanying drawing 5, the difference part only is termination electrode 5, body electrode 10 is not to draw by the tube chamber 19 of electrode support 1 one sides, but draw by central lumen 11, it is characterized in that said axial lumen has two, one is to be positioned at support 1 center, lead to the tube chamber 11 of rear end from the support front end, another is the tube chamber 19 that is positioned at support 1 axis one side, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is two electrodes 9,10, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters tube chamber 11, pass from another radial hole 14 then and twine adult electrode 10, the other end of body electrode 10 enters tube chamber 11 from radial hole 16 and links with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 11, and an end of body electrode 9 is fixed on the support, and the radial hole 13 of the other end on support 1 enters tube chamber 19,3 link with lead-in wire, lead-in wire 3 is drawn from the support rear end through tube chamber 19.
Similar with the multipolar design in single chamber, accompanying drawing 7, accompanying drawing 8 has provided two kind of two multipolar scheme in chamber, accompanying drawing 7 is characterised in that said axial lumen has two, one is to be positioned at support 1 center, lead to the tube chamber 11 of rear end from the support front end, another is the tube chamber 19 that is positioned at support 1 axis one side, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is plural, the electrode group 9 that the interval links, 10, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters tube chamber 19, pass from another radial hole 14 then and twine adult electrode group 10, the other end of body electrode group 10 enters tube chamber 19 from radial hole 16 and links with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 19, one end of body electrode group 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters tube chamber 11, pass from another radial hole 15 then, be wound in next individual electrode 9, organizator electrode group 9, the other end of body electrode group 9 enters central lumen 11 through radial hole 13 and links with lead-in wire 3, and lead-in wire 3 is drawn from the support rear end through tube chamber 11.
Accompanying drawing 8 is characterised in that said axial lumen has two, one is to be positioned at support 1 center, lead to the tube chamber 11 of rear end from the support front end, another is the tube chamber 19 that is positioned at support 1 axis one side, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is plural, the electrode group 9 that the interval links, 10, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters tube chamber 11, pass from another radial hole 14 then and twine adult electrode group 10, the other end of body electrode group 10 enters tube chamber 11 from radial hole 16 and links with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 11, one end of body electrode group 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters tube chamber 19, pass from another radial hole 15 then, be wound in next individual electrode 9, organizator electrode group 9, the other end of body electrode group 9 enters tube chamber 19 through radial hole 13 and links with lead-in wire 3, and lead-in wire 3 is drawn from the support rear end through tube chamber 19.
Accompanying drawing 9 has provided a kind of three chambeies two utmost point electrode structure sketch maps, it is characterized in that said axial lumen has three, one is to be positioned at support 1 center, lead to the cavity 11 of rear end from the support front end, one is the tube chamber 19 that is positioned at support 1 axis one side, one is the tube chamber 20 that is positioned at support 1 axis opposite side, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is an electrode 9, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters tube chamber 19, link with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 19, and an end of body electrode 9 is fixed on the support, and the radial hole 13 of the other end on support 1 enters tube chamber 20,3 link with lead-in wire, lead-in wire 3 is drawn from the support rear end through tube chamber 20.
Accompanying drawing 10 is a kind of three chambeies three utmost point electrode structure sketch maps, it is characterized in that said axial lumen has three, one is to be positioned at support 1 center, lead to the cavity 11 of rear end from the support front end, one is the tube chamber 19 that is positioned at support 1 axis one side, one is the tube chamber 20 that is positioned at support 1 axis opposite side, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is two electrodes 9,10, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters tube chamber 19, pass from another radial hole 14 then and twine adult electrode 10, the other end of body electrode 10 enters tube chamber 19 from radial hole 16 and links with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 19, one end of body electrode 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters tube chamber 20,3 links with lead-in wire, and lead-in wire 3 is drawn from the support rear end through tube chamber 20.
Accompanying drawing 11 is the multipole electrode structure sketch maps in a kind of three chambeies, it is characterized in that said axial lumen has three, one is to be positioned at support 1 center, lead to the cavity 11 of rear end from the support front end, one is the tube chamber 19 that is positioned at support 1 axis one side, one is the tube chamber 20 that is positioned at support 1 axis opposite side, said therapeutic electrode adopts wire electrode to be entwined, said body electrode is plural, the electrode group 9 that the interval links, 10, one end of termination electrode 5 wire electrodes is fixed on the support, the radial hole 12 of the other end on support 1 enters tube chamber 19, pass from another radial hole 14 then and twine adult electrode group 10, the other end of body electrode group 10 enters tube chamber 19 from radial hole 16 and links with lead-in wire 2, lead-in wire 2 is drawn from the support rear end through tube chamber 19, one end of body electrode group 9 is fixed on the support, the radial hole 13 of the other end on support 1 enters tube chamber 20, pass from another radial hole 15 then, be wound in next individual electrode 9, organizator electrode group 9, the other end of body electrode group 9 enters tube chamber 20 through radial hole 13 and links with lead-in wire 3, and lead-in wire 3 is drawn from the support rear end through tube chamber 20.
Above-described embodiment all adopts the structure of center cavity 11 to the focus fluid injection, this is being not too easily in some cases, for this reason, the present invention has provided the design that has special-purpose fluid injection tube chamber 18 on a kind of electrode support, it is characterized in that being provided with a fluid injection tube chamber 18 in one of support central lumen 11, it has inlet 7 in the support rear end, at the support front end delivery outlet 17 is arranged, and so just can need import saline solution or medicine to focus according to what treat at any time.Particularly hindered dead tube chamber, Endangered in the patient of death for esophageal carcinoma piece, can be earlier with clear the way electrode and termination electrode 5 electrode that partners, the saline solution that injects can play electrolytical effect, at first produce electrolysis, effect such as electrodialysis, electrophoresis, open path, then electrode is inserted focus and treat, beyond thought therapeutic effect can be arranged.The support structure that has fluid injection tube chamber 18 is referring to Figure 13, and it is applicable to above-mentioned all electrode design schemes.
The electrode group of being made up of termination electrode 5 and body electrode 9,10 can obtain curative effect preferably to general patient with esophageal carcinoma, but can't insert owing to electrode for constrictive type, the dead type patient of resistance, can't implement electrochemotherapy sometimes.For this reason, specialized designs of the present invention a kind of electrode that clears the way.The electrochemical electrode that has the above-mentioned various schemes of the electrode that clears the way is characterised in that the electrode 22 that clears the way that can insert, extract out, tape insulation pipe 21 in the central lumen 11, the part that electrode support front end is exposed in the end of open electrode is exposed electrode tip 6, part in the insulation tube 21 is an open electrode lead-in wire 23, lead-in wire 23 is drawn from the support rear end through tube chamber 11, thereafter the end is an electrode terminal, and operating handle 8 is housed.
Clear the way the structure of electrode referring to accompanying drawing 12, and known straight type pin can be adopted in its termination 6, also can adopt numb fagoting, can also adopt the spiral wire electrode.The lead-in wire 23 of electrode of clearing the way can be designed to integral structure with electrode tip 6, adopts platinum or platinum base alloy to make equally, also can adopt stainless steel silk or copper wire; Can be weldingly connected with termination 6, also can be with lead-in wire 23 head design aperture, termination 6 connection that inserts in the hole.The electrode that clears the way is specially adapted to the dead type cancer piece of treatment resistance, constriction shape ulcer type tumor.
When the lead-in wire of electrode of clearing the way adopts stainless steel silk because stainless steel silk has certain elasticity, rigidity, so can also play guiding function, make entire electrode insertion, extract and can carry out smoothly.
The used flexible insulating material of electrode support can adopt medical polyvinyl pipe, polyethylene tube, stomach tube or silicone rubber tube among the present invention, its caliber can adopt 2mm-20mm, usually the pipe of φ 3, φ 5, φ 7, φ 10 is used morely, its length can be 10cm-100cm, can make series of products according to purposes.Termination electrode 5, body electrode 9,10 can adopt platinum filament or Pt-base alloy wire (as platinum-rhodium wire, platinoiridita line or platinoid silk) to be entwined as wire electrode, its diameter can be 0.1mm～1mm, with 0.3mm is best, the minimum number of turns of electrode is a circle, can arrive 150 circles at most, the number of body electrode 9,10 can be 1～50.To the design of a termination electrode 5, an individual electrode 9, the number of turns of the two all can be 150 circles, forms the fit electrode of high surface area.Usually, the number of turns of electrode, number will adapt with patient's the state of an illness, with the total length of electrode on support 1 less than, equal diseased region length and be advisable.For the scheme of a plurality of body electrodes 9,10, the number of turns of body electrode 9,10 with 10 circles for well.For wire electrode is located easily, can have on the support 1 and wire electrode diameter corresponding grooves, the front end of support 1 can have a chimb, in case wire electrode comes off.The scheme that wire electrode one end is fixed on the support 1 can be: immerse oneself in (head is inserted in the aperture on the support 1) or pressure head (its termination being pushed down with the wire electrode that twines).It also is highly effective adopting the gluing localized method of wire electrode that makes.
The another embodiment of termination electrode 5, body electrode 9,10 is to adopt platinum or platinum base alloy sheet to make end cap, annulus, links with lead-in wire again.
Operation principle of the present invention is as follows: when adding DC voltage (be lower than 10 volts, electric current is lower than 100 milliamperes) on two electrodes 2,3, around electrode a series of redox reaction take place, we study its detailed mechanism.The positive polarity district is highly acid around electrode, and about pH=2, the district is strong basicity in negative polarity, about pH=12.Protein precipitation loses activity degeneration simultaneously.Produce newborn oxygen, chlorine on anodal region electrode, it has strong oxidation destruction to cancerous tissue.Produce newborn hydrogen in the negative pole district, make tissue that reduction reaction take place, cause the hole.Cancerous tissue produces a series of electrochemical reactions on electrode, correspondingly just cause a series of electrophysiologic responses.Thrombosis for example, vasoconstriction, thus cause cancerous cell to destroy and dead.
The scope of application of the present invention is as follows: medullary, ulcer type, constrictive type, ulcer constrictive type.Diseased region: cervical part of esophagus, breast epimere, section, breast hypomere in the heart.All patients carry out esophageal barium meal perspective, fibergastroscopy, and behind electrochemotherapy, patient all can take food, and has obviously improved patient's life, make some critical illness people remove the hardship and the prolongation life of intravenous nutrition.
Therapeutic Method of the present invention is as follows: at first the whole body situation checked comprehensively, carried out the esophagus barivm meal fluoroscopy (screem), and fibergastroscopy, and turn out to be esophageal carcinoma through pathology.Under television perspective, overall process is carried out cardiac monitoring.Insert treatment esophageal carcinoma electrode from nasal cavity or oral cavity, enter diseased region, control with the tumor size and decide scheme.It is voltage below 10 volts that ordinary circumstance adopts data, and electric current is below 100 milliamperes, the dosage that each cubic centimetre acceptance is 50 coulombs, and Rapid Dose Calculation adds up.
Figure 14 has provided the structural representation of a practical electrode, and it has two lead-in wire tube chambers 19,20, is installed with the electrode that clears the way in the central lumen 11, has fluid injection tube chamber 18 in a side of support 1, and support 1 rear end has operating grip.
Figure 15 has provided the profile sketch map of practical electrode, and it is elongated, flexible, a cylinder that have the electrode that clears the way, that be convenient to insert esophagus.
Claims (17)
1, a kind of electrode of electrochemotherapy esophageal carcinoma, comprise and making by flexible insulating material, inside has the electrode support (1) of axial lumen and is arranged on the therapeutic electrode on electrode support surface, contact conductor (2 in therapeutic electrode and the support axial lumen, 3) link, lead-in wire (2,3) draw from the rear end of axial lumen, it is characterized in that said therapeutic electrode is made up of the body electrode (9) that the termination electrode (5) that is arranged on electrode support (1) front end and at least one are arranged on electrode support (1) surface, therapeutic electrode adopts wire electrode to be entwined, one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support enters axial lumen and lead-in wire (2) links, one end of body electrode (9) is fixed on the support (1), the radial hole (13) of the other end on support (1) enters axial lumen and lead-in wire (3) links, said support axial lumen comprises that at least is positioned at a support center, from the cavity (11) that the support front end leads to the rear end, the part of wire electrode in axial lumen, lead-in wire (2,3) all have insulated sleeve.
2, electrode as claimed in claim 1, it is characterized in that said body electrode is two electrodes (9,10), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters central lumen (11), pass from another radial hole (14) then and twine adult electrode (10), the other end of body electrode (10) enters central lumen (11) through radial hole (16), links with lead-in wire (2).
3, electrode as claimed in claim 1, it is characterized in that said body electrode is plural, the electrode group (9 that the interval links, 10), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters central lumen (11), pass from another radial hole (14) then and twine adult electrode group (10), the other end of body electrode group (10) enters central lumen (11) through radial hole (16), link with lead-in wire (2), one end of body electrode group (9) is fixed on the support, the radial hole (13) of the other end on support (1) enters central lumen (11), pass from another radial hole (15) then, be wound in next individual electrode (9), organizator electrode group (9), the other end of body electrode group (9) enters central lumen (11) through radial hole (13) and links with lead-in wire (3).
4, electrode as claimed in claim 1, it is characterized in that said axial lumen has two, one is to be positioned at support (1) center, lead to the cavity (11) of rear end from the support front end, another is the tube chamber (19) that is positioned at support (1) axis one side, said body electrode is two electrodes (9,10), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters tube chamber (19), pass from another radial hole (14) then and twine adult electrode (10), the other end of body electrode (10) enters tube chamber (19) from radial hole (16) and links with lead-in wire (2), lead-in wire (2) is drawn from the support rear end through tube chamber (19), one end of body electrode (9) is fixed on the support, the radial hole (13) of the other end on support (1) enters tube chamber (11), link with lead-in wire (3), lead-in wire (3) is drawn from the support rear end through tube chamber (11).
5, electrode as claimed in claim 1, it is characterized in that said axial lumen has two, one is to be positioned at support (1) center, lead to the cavity 11 of rear end from the support front end, another is the tube chamber (19) that is positioned at support (1) axis one side, said body electrode is two electrodes (9,10), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters tube chamber (11), pass from another radial hole (14) then and twine adult electrode (10), the other end of body electrode (10) enters tube chamber (11) from radial hole (16) and links with lead-in wire (2), lead-in wire (2) is drawn from the support rear end through tube chamber (11), one end of body electrode (9) is fixed on the support, the radial hole (13) of the other end on support (1) enters tube chamber (19), link with lead-in wire (3), lead-in wire (3) is drawn from the support rear end through tube chamber (19).
6, electrode as claimed in claim 1, it is characterized in that said axial lumen has two, one is to be positioned at support (1) center, lead to the cavity (11) of rear end from the support front end, another is the tube chamber (19) that is positioned at support (1) axis one side, said body electrode is plural, the electrode group (9 that the interval links, 10), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters tube chamber (19), pass from another radial hole (14) then and twine adult electrode group (10), the other end of body electrode group (10) enters tube chamber (19) from radial hole (16) and links with lead-in wire (2), lead-in wire (2) is drawn from the support rear end through tube chamber (19), one end of body electrode group (9) is fixed on the support, the radial hole (13) of the other end on support (1) enters tube chamber (11), pass from another radial hole (15) then, be wound in next individual electrode (9), organizator electrode group (9), the other end of body electrode group (9) enters central lumen (11) through radial hole (13) and links with lead-in wire (3), and lead-in wire (3) is drawn from the support rear end through tube chamber (11).
7, electrode as claimed in claim 1, it is characterized in that said axial lumen has two, one is to be positioned at support (1) center, lead to the cavity (11) of rear end from the support front end, another is the tube chamber (19) that is positioned at support (1) axis one side, said body electrode is plural, the electrode group (9 that the interval links, 10), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters tube chamber (11), pass from another radial hole (14) then and twine adult electrode group (10), the other end of body electrode group (10) enters tube chamber (11) from radial hole (16) and links with lead-in wire (2), lead-in wire (2) is drawn from the support rear end through tube chamber (11), one end of body electrode group (9) is fixed on the support, the radial hole (13) of the other end on support (1) enters tube chamber (19), pass from another radial hole (15) then, be wound in next individual electrode group (9), organizator electrode (9), the other end of body electrode group (9) enters tube chamber (19) through radial hole (13) and links with lead-in wire (3), and lead-in wire (3) is drawn from the support rear end through tube chamber (19).
8, electrode as claimed in claim 1, it is characterized in that said axial lumen has three, one is to be positioned at support (1) center, lead to the cavity (11) of rear end from the support front end, one is the tube chamber (19) that is positioned at support (1) axis one side, one is the tube chamber (20) that is positioned at support (1) axis opposite side, said body electrode is two electrodes (9), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters tube chamber (19), link with lead-in wire (2), lead-in wire (2) is drawn from the support rear end through tube chamber (19), one end of body electrode (9) is fixed on the support, the radial hole (13) of the other end on support (1) enters tube chamber (20), link with lead-in wire (3), lead-in wire (3) is drawn from the support rear end through tube chamber (20).
9, electrode as claimed in claim 1, it is characterized in that said axial lumen has three, one is to be positioned at support (1) center, lead to the cavity (11) of rear end from the support front end, one is the tube chamber (19) that is positioned at support (1) axis one side, one is the tube chamber (20) that is positioned at support (1) axis opposite side, said body electrode is two electrodes (9,10), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters tube chamber (19), pass from another radial hole (14) then and twine adult electrode (10), the other end of body electrode (10) enters tube chamber (19) from radial hole (16) and links with lead-in wire (2), lead-in wire (2) is drawn from the support rear end through tube chamber (19), one end of body electrode (9) is fixed on the support, the radial hole (13) of the other end on support (1) enters tube chamber (20), link with lead-in wire (3), lead-in wire (3) is drawn from the support rear end through tube chamber (20).
10, electrode as claimed in claim 1, it is characterized in that said axial lumen has three, one is to be positioned at support (1) center, lead to the cavity (11) of rear end from the support front end, one is the tube chamber (19) that is positioned at support (1) axis one side, one is the tube chamber (20) that is positioned at support (1) axis opposite side, said body electrode is plural, the electrode group (9 that the interval links, 10), one end of termination electrode (5) wire electrode is fixed on the support, the radial hole (12) of the other end on support (1) enters tube chamber (19), pass from another radial hole (14) then and twine adult electrode group (10), the other end of body electrode group (10) enters tube chamber (19) from radial hole (16) and links with lead-in wire (2), lead-in wire (2) is drawn from the support rear end through tube chamber (19), one end of body electrode group (9) is fixed on the support, the radial hole (13) of the other end on support (1) enters tube chamber (20), pass from another radial hole (15) then, be wound in next individual electrode (9), organizator electrode group (9), the other end of body electrode group (9) enters tube chamber (20) through radial hole (13) and links with lead-in wire (3), and lead-in wire (3) is drawn from the support rear end through tube chamber (20).
11, as the electrode of claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10, it is characterized in that a fluid injection tube chamber 18 being arranged in a side of support (1), it has inlet (7) in the support rear end, at the support front end delivery outlet (17) is arranged.
12, as the electrode of claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10, the part that it is characterized in that having in the central lumen (11) end that can insert, extract out, the electrode that clears the way (22) of tape insulation pipe (21), the electrode that clears the way to expose electrode support front end is exposed electrode tip (6), part in the insulation tube (21) is the contact conductor that clears the way (23), lead-in wire (23) is drawn from the support rear end through tube chamber (11), thereafter the end is an electrode terminal, and operating handle (8) is housed.
13, as the electrode of claim 11, it is characterized in that having in the central lumen (11) electrode that clears the way (22) that can insert, extract out, tape insulation pipe (21), the part that the end of electrode exposes electrode support front end of clearing the way is exposed electrode tip (6), part in the insulation tube (21) is the contact conductor that clears the way (23), lead-in wire (23) is drawn from the support rear end through tube chamber (11), thereafter the end is an electrode terminal, and operating handle (8) is housed.
14, as the electrode of claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10, the flexible material that it is characterized in that said making support can adopt medical polyvinyl pipe or polyethylene tube or stomach tube or silicone rubber tube, its caliber can be 2mm～20mm, length can be 10cm～100cm, said wire electrode can adopt platinum filament or platinum-rhodium wire or platinoiridita silk or platinoid silk, its diameter can be 0.1mm～1mm, the number of turns of termination electrode (5) can be 1～150 circle, the number of turns of body electrode (9,10) can be 1～150 circle, and the number of turns of body electrode (9,10) can be 1～50.
15, as the electrode of claim 11, the flexible material that it is characterized in that said making support can adopt medical polyvinyl pipe or polyethylene tube or stomach tube or silicone rubber tube, its caliber can be 2mm～20mm, length can be 10cm～100cm, said wire electrode can adopt platinum filament or platinum-rhodium wire or platinoiridita silk or platinoid silk, its diameter can be 0.1mm～1mm, the number of turns of termination electrode (5) can be 1～150 circle, the number of turns of body electrode (9,10) can be 1～150 circle, and the number of body electrode (9,10) can be 1～50.
16, as the electrode of claim 12, the flexible material that it is characterized in that said making support can adopt medical polyvinyl pipe or polyethylene tube or stomach tube or silicone rubber tube, its caliber can be 2mm～20mm, length can be 10cm～100cm, said wire electrode can adopt platinum filament or platinum-rhodium wire or platinoiridita silk or platinoid silk, its diameter can be 0.1mm～1mm, the number of turns of termination electrode (5) can be 1～150 circle, the number of turns of body electrode (9,10) can be 1～150 circle, and the number of body electrode (9,10) can be 1～50.
17, as the electrode of claim 13, the flexible material that it is characterized in that said making support can adopt medical polyvinyl pipe or polyethylene tube or stomach tube or silicone rubber tube, its caliber can be 2mm～20mm, length can be 10cm～100cm, said electrode wires can adopt platinum filament or platinum-rhodium wire or platinoiridita silk or platinoid silk, its diameter can be 0.1mm～1mm, the number of turns of termination electrode (5) can be 1～150 circle, the number of turns of body electrode (9,10) can be 1～150 circle, and the number of body electrode (9,10) can be 1～50.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92113243 CN1026067C (en) | 1992-12-04 | 1992-12-04 | Electrode for electrochemical therapy of esophageal cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92113243 CN1026067C (en) | 1992-12-04 | 1992-12-04 | Electrode for electrochemical therapy of esophageal cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1075658A CN1075658A (en) | 1993-09-01 |
| CN1026067C true CN1026067C (en) | 1994-10-05 |
Family
ID=4946315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92113243 Expired - Fee Related CN1026067C (en) | 1992-12-04 | 1992-12-04 | Electrode for electrochemical therapy of esophageal cancer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1026067C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102686273A (en) * | 2009-12-30 | 2012-09-19 | 心脏起搏器公司 | Terminal connector assembly for a medical electrical lead |
| US9945467B2 (en) | 2013-11-07 | 2018-04-17 | Schaeffler Technologies AG & Co. KG | Supporting assembly for a lightweight differential |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102500060A (en) * | 2011-12-02 | 2012-06-20 | 李开华 | Intelligent electrochemical tumor treating system |
| CN103143116B (en) * | 2013-02-20 | 2015-07-29 | 天津医科大学总医院 | Implant electrode automatic sensing digestive tract order pacing therapy instrument under mucosa |
-
1992
- 1992-12-04 CN CN 92113243 patent/CN1026067C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102686273A (en) * | 2009-12-30 | 2012-09-19 | 心脏起搏器公司 | Terminal connector assembly for a medical electrical lead |
| US9945467B2 (en) | 2013-11-07 | 2018-04-17 | Schaeffler Technologies AG & Co. KG | Supporting assembly for a lightweight differential |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1075658A (en) | 1993-09-01 |
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