CN102599263A - DHA (dehydroacetic acid)-containing fatty acid ratio functional oil with blood fat regulation function - Google Patents
DHA (dehydroacetic acid)-containing fatty acid ratio functional oil with blood fat regulation function Download PDFInfo
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Abstract
The invention provides an application of dehydroacetic acid (DHA)-containing novel fatty acid ratio functional oil in preventing and treating hyperlipidaemia, and further discloses an application of the fatty acid ratio functional oil in preparing foods for preventing and treating symptoms or diseases related to lipid metabolic disease. The functional oil has an effect of keeping weight or reducing weight to animals, and can influence the serum lipids metabolism, so that the total cholesterol and triglyceride of a body are controlled at a low level, and the content of low-density lipoprotein can be reduced. According to the invention, the functional oil can be used for regulating the serum lipids metabolism of the body, reducing the level of total cholesterol and triglyceride, and reducing the content of the low density lipoprotein easily causing diseases of the cardiovascular system, has the effect of preventing and treating the hyperlipidaemia, and is expected to be applied to preparation of foods for preventing and treating symptoms or diseases related to the lipid metabolic disease.
Description
(1) invention field:
The present invention relates to a kind of function grease, relate in particular to a kind of aliphatic acid proportioning function grease that the adjusting blood fat contains DHA that has.
(2) background of invention:
Along with socioeconomic fast development, China resident's living standard improves day by day, thus the relation of consumers in general and researcher daily edible oil and fat of also increasing concern and health.Edible oil and fat play an important role in people's diet health.In recent years research shows that different fatty acid proportions can produce different action effects to the lipid metabolism of body with the long-term health effect in the meals.Reasonably the aliphatic acid proportioning can effectively be regulated the lipid metabolism of body, the generation of prevention and minimizing metabolism disorder of blood lipid property disease.In edible oil and fat, the ratio of polyunsaturated fatty acid has very important significance to keeping the normal physiological metabolism of body.DHA (DHA) is as a kind of important polyunsaturated fatty acid; Many physiological functions to body have good positivity regulating action, as improve blood lipid metabolism angiocardiopathy preventing, auxiliary improvement of memory, promotion children ' s intelligence development, prophylaxis of tumours generation and improve eyesight etc.DHA can effectively reduce blood plasma low-density lipoprotein white level, increases hdl concentration, thereby reduces blood viscosity, improves blood circulation, and increases the drainage of cholesterol, reduces content of cholesterol in the blood.DHA also can reduce hematoblastic cohesion through the desaturase in the control arachidonic acid metabolic pathway and the activity of cyclo-oxygenase, reduces the probability that thrombus and atherosclerotic form.
In order to satisfy growing consumption demand of people and health demand, need continually develop the functional form oil and fat product of development to different crowd and different demands.Therefore, further deeply inquire into different dietary fatty acid ratios and the health effect of different DHA, illustrate its concrete action effect, can be the basic health that improves China resident and lay the foundation body.
(3) summary of the invention:
The object of the present invention is to provide a kind of aliphatic acid proportioning function grease that the adjusting blood fat contains DHA that has; The preparation method simple possible of said function grease; Promptly with novel aliphatic acid proportioning preparation edible oil and fat; And in edible oil and fat, add DHA by a certain percentage, belong to already known processes and mature technology.
Technical scheme of the present invention:
The purposes of aliphatic acid proportioning function grease aspect prevention and treatment hyperlipidemia that contains DHA.
The aliphatic acid proportioning function grease of the above-mentioned said DHA of containing is used for preventing the purposes of the food of relevant with metabolism disorder of blood lipid symptom with treatment or disease in preparation.
Above-mentioned said relevant symptom with metabolism disorder of blood lipid or disease comprise: hyperlipidemia, atherosclerotic, hypertension, coronary heart disease, cerebrovascular disease etc.
Above-mentioned said realization is above-mentioned to be used to prevent the preparation of the purposes of relevant with metabolism disorder of blood lipid symptom with treatment or disease, comprises the new function grease that prevents and/or treats, and the acceptable excipient of food.
Above-mentioned said realization is above-mentioned, and to be used to prevent the preparation of the purposes of relevant with metabolism disorder of blood lipid symptom with treatment or disease be edible oil lipid, healthy oils class or health food.
The acceptable excipient of above-mentioned said food can be the excipient of any routine in the food formulation field; The selection of particular excipient will be depended on administering mode or disease type and the state that is used to treat particular patient, and the preparation method of appropriate formulation who is used for the specific administration pattern is fully in field of food technical staff's ken.For example; Can be used as diluent, carrier, filler, adhesive, wetting agent, disintegrant, sorbefacient, surfactant, absorption carrier and lubricant etc. that the acceptable excipient of food comprises that field of food is conventional; In case of necessity, can also in preparation, add flavouring agent, anticorrisive agent and sweetener etc.
Above-mentioned said realization is above-mentioned to be used to prevent the preparation of the purposes of relevant with metabolism disorder of blood lipid symptom with treatment or disease; Can be made into the formulation of any suitable application, comprising: various ways such as edible oil, healthy oils, capsule, oral liquid, drops or beverage.The preparation of above-mentioned various formulations all can be according to the conventional method preparation of field of food.
Above-mentioned said realization is above-mentioned, and to be used to prevent the preparation of the purposes of relevant with metabolism disorder of blood lipid symptom with treatment or disease be capsule, oral liquid, drops or beverage.
Superiority of the present invention is: the novel fatty acid proportioning function grease that 1, contains DHA can be regulated the blood lipid metabolism of Wistar rat, makes the total plasma cholesterol of body and triglycerides be controlled at the low level level, and can reduce the content of low-density lipoprotein; 2 and said function grease can play animal and keep body weight or antiobesity action preferably; 3, the blood lipid metabolism of this functional grease scalable body; Reduce total plasma cholesterol and triglyceride levels; And reduce the content of the low-density lipoprotein be easy to cause disease of cardiovascular system; Have prevention and treatment effect on hyperlipemia, be expected to be used for preventing food to use with unusual relevant symptom of treatment and blood lipid metabolism or disease in preparation.
(4) description of drawings:
The variation diagram of Fig. 1 rat body weight (1-7 group is represented normal control group, FA1+DHA1 group, FA1+DHA2 group, FA1+DHA3 group, FA2+DHA1 group, FA2+DHA2 group and FA2+DHA3 group respectively), down with.
The variation diagram of total cholesterol level in Fig. 2 rat plasma.
The variation diagram of triglyceride levels in Fig. 3 rat plasma.
The variation diagram of low-density lipoprotein content in Fig. 4 rat plasma.
The variation diagram of Fig. 5 rat plasma middle-high density lipoprotein content.
(5) specific embodiment:
In order to make those skilled in the art better understand technical scheme of the present invention, technical scheme according to the invention is done further to specify below in conjunction with the specific embodiment.
The novel fatty acid proportioning function grease that contains DHA is regulated the experimental study of blood lipid metabolism
1. materials and methods
With a cleaning level Wistar rat is research object, healthy male, and body weight 100g-120g is provided by Military Medical Science Institute's animal center, and SPF level Animal House is raised, and the Animal House temperature is controlled at (24 ± 1) ℃, and humidity is 50%-70%, light dark period is 12h: 12h.
Animal used as test is divided into 7 groups after adapt to feeding for 1 week at random: dose groups (FA2+DHA2), aliphatic acid proportioning 2+DHA high dose group (FA2+DHA3) among dose groups (FA1+DHA2), aliphatic acid proportioning 1+DHA high dose group (FA1+DHA3), aliphatic acid proportioning 2+DHA low dose group (FA2+DHA1), the aliphatic acid proportioning 2+DHA among normal control group, aliphatic acid proportioning 1+DHA low dose group (FA1+DHA1), the aliphatic acid proportioning 1+DHA, 9 every group.Grease gives every day 1 time to irritate the stomach mode.Animal freely ingests and drinks water.
Every morning is irritated stomach to animal used as test, body weight of weighing weekly, and be 5 months total experimental period.The the the 1st, the 2nd, the 3rd and the 4th the end of month, adopt the eye socket vein to get blood respectively, separated plasma ,-20 ℃ of preservations are subsequent use.When experiment finishes, with the animal sacrificed by decapitation, collect blood sample, separated plasma ,-20 ℃ of preservations are subsequent use.
2. result
2.1 the influence that the new function grease changes rat body weight
Experimental result is carried out one-way analysis of variance (one-way ANOVA), and carry out the comparison between each group with Newman-Keuls method (q check).The result shows that in the time of 2nd month, each is organized body weight and engenders difference in experiment beginning back, increases in time, and the difference more and more significant, when finishing to experiment, the normal control group of 5,6,7 groups body weight obviously reduces especially the 6th group; 2,3,4 groups body weight then obviously increases (see figure 1).
2.2 the new function grease is to the influence of T-CHOL in the rat plasma and triglyceride levels
Experimental result is carried out one-way analysis of variance (one-way ANOVA), and carry out the comparison between each group with Newman-Keuls method (q check).The result shows that 5,6,7 groups of rat plasma total cholesterol levels are low than 2,3,4 groups of rats, particularly the 7th group, significantly are lower than the horizontal (see figure 2) of other each groups.The triglycerides testing result shows that the content of triglyceride of 5,6,7 groups of rat plasmas is in the low level level, and the plasma triglyceride content of 3,4 groups of rats is significantly higher than the normal control group, and the triglyceride levels of the 2nd group of rat is between middle (see figure 3).
2.3 the new function grease is to the influence of low-density lipoprotein in the rat plasma and hdl concentration
Experimental result is carried out one-way analysis of variance (one-way ANOVA), and carry out the comparison between each group with Newman-Keuls method (q check).The result shows that the low-density lipoprotein of 5,6,7 groups of rat plasmas changes in the low level level, and 2,4 groups then in the horizontal (see figure 4) of a high position.All in all, it is little that each organizes rat plasma hdl concentration variation difference, but when the 2nd the end of month, differ greatly between each group, and 2,6 groups of content are higher, 3,5 groups of low (see figure 5)s of content.
Conclusion: above experiment shows, with novel fatty acid proportioning (FA2) function grease rat is intervened, and can exert an influence to the weight of animals, plays and keeps body weight or antiobesity action preferably.And the blood lipid metabolism of animal exerted an influence, can make the total plasma cholesterol of body and triglycerides be controlled at the low level level, and can reduce the content of low-density lipoprotein, but little to the HDL influence.The novel fatty acid proportioning function grease that prompting contains DHA has the effect of regulating blood lipid metabolism, so can be used for preventing with treat hyperlipidemia or with unusual relevant symptom or the disease of blood lipid metabolism.
Can adopt the routine techniques in the grease field, different aliphatic acid are carried out proportioning, and add DHA, prepare the preparation that is used for preventing and/or treating with the food of unusual relevant symptom of blood lipid metabolism or disease.
Get edible oil, in saturated fatty acid: monounsaturated fatty acids: the ratio of polyunsaturated fatty acid=0.5: 1.3: 1.3 is prepared, and adds DHA 8mg/100g grease, and mixing promptly gets novel edible oil and fat.
Get edible oil, in saturated fatty acid: monounsaturated fatty acids: the ratio of polyunsaturated fatty acid=0.3: 1.5: 1.5 is prepared, and adds DHA 500mg/100g grease, and mixing promptly gets the health grease.
Get edible oil; In saturated fatty acid: monounsaturated fatty acids: the ratio of polyunsaturated fatty acid=0.1: 2.5: 2.5 is prepared, and adds DHA 400mg/100g grease, and mixing also adds an amount of excipient; Pack in No. 2 capsules, promptly get function grease capsule.
Get edible oil, in saturated fatty acid: monounsaturated fatty acids: the ratio of polyunsaturated fatty acid=0.2: 2: 2.1 is prepared, and adds DHA 200mg/100g grease, and mixing also carries out emulsification, can get the oral liquid of function grease.
Above-mentioned detailed description of the purposes of this function grease being carried out with reference to the specific embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (7)
1. the purposes of aliphatic acid proportioning function grease aspect prevention and treatment hyperlipidemia that contains DHA.
2. purposes according to claim 1, the aliphatic acid proportioning function grease of the said DHA of containing are used for preventing the purposes of the food of relevant with metabolism disorder of blood lipid symptom with treatment or disease in preparation.
3. purposes according to claim 2, said relevant symptom with metabolism disorder of blood lipid or disease comprise: hyperlipidemia, atherosclerotic, hypertension, coronary heart disease, cerebrovascular disease etc.
4. purposes according to claim 2 realizes the above-mentioned preparation that is used to prevent the purposes of relevant with metabolism disorder of blood lipid symptom with treatment or disease, comprises the function grease that prevents and/or treats, and the acceptable excipient of food.
5. purposes according to claim 4 realizes that above-mentioned to be used to prevent the preparation of the purposes of relevant with metabolism disorder of blood lipid symptom with treatment or disease be edible oil lipid, healthy oils class or health food.
6. according to claim 4 or 5 described purposes, realize the above-mentioned preparation that is used to prevent the purposes of relevant with metabolism disorder of blood lipid symptom with treatment or disease, can be made into the formulation of any suitable application.
7. purposes according to claim 6 realizes that above-mentioned to be used to prevent the preparation of the purposes of relevant with metabolism disorder of blood lipid symptom with treatment or disease be edible oil, healthy oils, capsule, oral liquid or beverage.
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Cited By (1)
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| CN110141564A (en) * | 2019-06-06 | 2019-08-20 | 广东省农业科学院蚕业与农产品加工研究所 | A kind of glyceride mixture and its preparation method and application rich in polyunsaturated fatty acid |
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Application publication date: 20120725 |