CN102584900A - Noble metal coordination compound and preparation method thereof - Google Patents
Noble metal coordination compound and preparation method thereof Download PDFInfo
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- CN102584900A CN102584900A CN2012100180842A CN201210018084A CN102584900A CN 102584900 A CN102584900 A CN 102584900A CN 2012100180842 A CN2012100180842 A CN 2012100180842A CN 201210018084 A CN201210018084 A CN 201210018084A CN 102584900 A CN102584900 A CN 102584900A
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Abstract
The invention provides a noble metal coordination complex and a preparation method thereof, aims to prepare a coordination compound with potential medicinal values, and is characterized in that potassium chloropalladite or potassium chloroplatinite and 2,2'-bipyridine4,4'-dicarboxylic acid are mixed according to certain molar ratio and then react under hydrothermal conditions to obtain the coordination compound. The preparation method comprises the following steps: the mixrure of potassium chloropalladite (chloroplatinite), 2,2'-bipyridine4,4'-dicarboxylic acid and water is stirred for thirty minutes under the ambient temperature, then the mixture is transferred into a polytetrafluoroethylene inner container (with the volume of 25 to 50 mL) of a hydrothermal reaction kettle, the temperature is reduced to the ambient temperature, and a [PdLCl2]*H2O yellow rectangular ([PdLCl2]*H2O brownish red rectangular) crystal is obtained. The compound is definite in composition and molecular structure and has potential medicine application values.
Description
Technical field
The present invention relates to a kind of compound and preparation method thereof, particularly relate to a kind of precious metal coordination compound and preparation method thereof, synthetic and potential pharmaceutical use for the hydro-thermal of palladium, platinum title complex.
Background technology
Palladium, platinum be respectively with 2,2'-dipyridyl-4, the method for preparing single crystal of 4'-dicarboxylicacid and structure thereof.In recent years, be to construct the focus that piece assembling new type of metal title complex has become people's research with organic carboxyl acid.Carboxylic acid cpd has abundant coordination structure type, and the title complex that they form often has novel structure and wide application prospect.Aspect pharmaceutical chemistry, a kind of preparation method of single crystal compound and structure thereof have the medicinal using value of potential; In structure aspects, because two metal ion species are all taked dsp
2Orbital hybridization mode and part bonding form the four-coordination plane quadrilateral, therefore, in platinum group, have palladium (II) only and have and similar constitutional features with platinum (II) two metal ion species title complexs; At the performance reverse side; Has high clinical value based on platinum (II) title complex in recent years; Palladium (II) title complex causes concern equally in the research work of anti-tumor aspect, and about they structure, anti-tumor activity and with the mode of action of DNA also by further investigation gradually.But because palladium (II) is difficult relatively with synthesizing of platinum (II) title complex; The present invention has synthesized by same part 2; 2'-dipyridyl-4; The metal complexes that the 4'-dicarboxylicacid forms with palladium and platinum respectively, this title complex and DNA have stronger effect, also are deeply to understand DNA as the targeted molecular of anticancer complex valuable information to be provided.
Summary of the invention
The object of the present invention is to provide a kind of preparation precious metal coordination compound [PdLCl
2] H
2O and [PtLCl
2] H
2The method of O has proposed in certain temperature range, adopts the low-temperature hydrothermal synthetic technology, with transition metal palladium, platinum respectively with 2,2'-dipyridyl-4, the 4'-dicarboxylicacid obtains this metal target coordination compound according to certain proportioning reaction.
The objective of the invention is to realize through following technical scheme:
The precious metal coordination compound is the title complex of potential pharmaceutical use, closes palladium acid potassium or potassium tetrachloroplatinate and 2 with tetrachloro, 2'-dipyridyl-4, and the 4'-dicarboxylicacid reacts under hydrothermal condition according to mol ratio, and obtains the target title complex; Coordination compound (1) [PdLCl
2] H
2The molecular structure of O is:
The preparation method of precious metal coordination compound, its preparation process is: tetrachloro is closed the sour potassium of palladium (platinum), 2,2'-dipyridyl-4; The mixture of 4'-dicarboxylicacid and water; At room temperature stirred 30 minutes, and transferred to mixture among hydrothermal reaction kettle polytetrafluoroethylliner liner, the volume 25-50mL constant temperature under 100-120 ° of C condition subsequently; Lower the temperature then up to room temperature, make [PdLCl
2] H
2O yellow rectangle { [PtLCl
2] H
2O red-brown rectangle } crystal.
Description of drawings
Fig. 1 is coordination compound (1) [PdLCl
2] H
2The molecular structure of O;
Fig. 2 is the molecular structure of coordination compound (2) [PtLCl2] H2O.
Embodiment
Fig. 1 is coordination compound (1) [PdLCl
2] H
2The molecular structure of O.In the Pd-N bond distance 2.010-2.020 scope, Pd-Cl bond distance is in the 2.296-2.297 scope.[PtLCl
2] H
2The same Fig. 1 of the molecular structure of O, in the Pt-N bond distance 2.000-2.005 scope, Pt-Cl bond distance is in the 2.298-2.299 scope.
New precious metals complex [PdLCl
2] H
2O and [PtLCl
2] H
2The compound method of O (L=2,2'-dipyridyl-4,4'-dicarboxylic acid radical) the present invention relates to title complex (1) [PdLCl
2] H
2O, (2) [PtLCl
2] H
2The preparation method of O monocrystalline and structure thereof relate to the preparation method and the structure thereof of a kind of single crystal compound of pharmaceutical chemistry aspect, this cooperation [PdLCl simultaneously
2] H
2O and [PtLCl
2] H
2In the O monocrystalline: L represents 2,2'-dipyridyl-4,4'-dicarboxylic acid radical.This method is with 2, and 2'-dipyridyl-4,4'-dicarboxylicacid part are accordinged to volume ratio collaborative and central ion palladium (II) and platinum (II) coordination with order, can obtain target title complex (1) [PdLCl
2] H
2O, (2) [PtLCl
2] H
2O.This method is closed palladium acid potassium (or potassium tetrachloroplatinate) and part 2 with tetrachloro, and 2'-dipyridyl-4,4'-dicarboxylicacid react (ratio of amount of substance is 1: 1) in hydro-thermal.The title complex composition and the molecular structure that are prepared into are clear and definite, have the potential medicinal application and are worth.
[PdLCl
2] H
2O{ [PtLCl
2] H
2O} closes the sour potassium of palladium (platinum) (0.2-0.4mmol) with tetrachloro, and 2,2'-dipyridyl-4,4'-dicarboxylicacid (0.2-0.4mmol) and H
2The mixture of O (10-15mL) at room temperature places mixture polytetrafluoroethylliner liner (volume 25-50mL) to stir 30 minutes, builds.Be positioned in the 100-120 ℃ of baking oven constant temperature after 20 hours, cooling obtains regular yellow rectangle (red-brown rectangle) crystal up to room temperature.
Claims (2)
1. precious metal coordination compound, the title complex for a kind of potential pharmaceutical use is characterized in that, closes palladium acid potassium or potassium tetrachloroplatinate and 2 with tetrachloro, 2'-dipyridyl-4, the 4'-dicarboxylicacid, according to mol ratio, reaction under hydrothermal condition, and acquisition target title complex; Coordination compound (1) [PdLCl
2] H
2The molecular structure of O is:
2. the preparation method of precious metal coordination compound is characterized in that, preparation process is: tetrachloro is closed the sour potassium of palladium (platinum), 2; 2'-dipyridyl-4, the mixture of 4'-dicarboxylicacid and water at room temperature stirred 30 minutes; Transfer to mixture among hydrothermal reaction kettle polytetrafluoroethylliner liner, the volume 25-50mL subsequently; Constant temperature under 100-120 ℃ of condition is lowered the temperature up to room temperature then, makes [PdLCl
2] H
2O yellow rectangle { [PtLCl
2] H
2O red-brown rectangle } crystal.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103214527A (en) * | 2013-04-27 | 2013-07-24 | 沈阳化工大学 | Noble metal platinum/palladium complex with bioactivity and preparation method thereof |
| CN103214526A (en) * | 2013-04-27 | 2013-07-24 | 沈阳化工大学 | Palladium/platinum mixed ligand coordination compound and preparation method thereof |
| CN103588817A (en) * | 2013-11-14 | 2014-02-19 | 沈阳化工大学 | Method for preparing complex crystal with biological activity |
| CN103977833A (en) * | 2014-05-20 | 2014-08-13 | 中国科学院福建物质结构研究所 | Preparation method and application of coordination polymer platinum-loaded nano-catalyst |
| CN104277079A (en) * | 2014-09-24 | 2015-01-14 | 沈阳化工大学 | Pd-Ln coordination polymers and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101531682A (en) * | 2009-04-10 | 2009-09-16 | 沈阳化工学院 | Metal coordination complex and method for preparing same |
| WO2009139939A2 (en) * | 2008-02-22 | 2009-11-19 | The University Of North Carolina At Chapel Hill | Hybrid nanoparticles as anti-cancer therapeutic agents and dual therapeutic/imaging contrast agents |
| CN101857610A (en) * | 2010-03-26 | 2010-10-13 | 沈阳化工学院 | Palladium complex and preparation method thereof |
-
2012
- 2012-01-20 CN CN2012100180842A patent/CN102584900A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009139939A2 (en) * | 2008-02-22 | 2009-11-19 | The University Of North Carolina At Chapel Hill | Hybrid nanoparticles as anti-cancer therapeutic agents and dual therapeutic/imaging contrast agents |
| CN101531682A (en) * | 2009-04-10 | 2009-09-16 | 沈阳化工学院 | Metal coordination complex and method for preparing same |
| CN101857610A (en) * | 2010-03-26 | 2010-10-13 | 沈阳化工学院 | Palladium complex and preparation method thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103214527A (en) * | 2013-04-27 | 2013-07-24 | 沈阳化工大学 | Noble metal platinum/palladium complex with bioactivity and preparation method thereof |
| CN103214526A (en) * | 2013-04-27 | 2013-07-24 | 沈阳化工大学 | Palladium/platinum mixed ligand coordination compound and preparation method thereof |
| CN103214526B (en) * | 2013-04-27 | 2015-11-18 | 沈阳化工大学 | palladium/platinum mixed ligand coordination compound and preparation method thereof |
| CN103214527B (en) * | 2013-04-27 | 2016-01-20 | 沈阳化工大学 | There is bioactive Noble metal platinum/palladium complex and preparation method thereof |
| CN103588817A (en) * | 2013-11-14 | 2014-02-19 | 沈阳化工大学 | Method for preparing complex crystal with biological activity |
| CN103977833A (en) * | 2014-05-20 | 2014-08-13 | 中国科学院福建物质结构研究所 | Preparation method and application of coordination polymer platinum-loaded nano-catalyst |
| CN104277079A (en) * | 2014-09-24 | 2015-01-14 | 沈阳化工大学 | Pd-Ln coordination polymers and preparation method thereof |
| CN104277079B (en) * | 2014-09-24 | 2017-07-18 | 沈阳化工大学 | A kind of Pd Ln coordination polymers and preparation method thereof |
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Application publication date: 20120718 |