CN102559111B - Styrene-series hot-melt pressure-sensitive adhesive and preparation method - Google Patents
Styrene-series hot-melt pressure-sensitive adhesive and preparation method Download PDFInfo
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- CN102559111B CN102559111B CN 201210022935 CN201210022935A CN102559111B CN 102559111 B CN102559111 B CN 102559111B CN 201210022935 CN201210022935 CN 201210022935 CN 201210022935 A CN201210022935 A CN 201210022935A CN 102559111 B CN102559111 B CN 102559111B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 36
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- 239000000203 mixture Substances 0.000 claims description 30
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- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 abstract description 15
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- FACXGONDLDSNOE-UHFFFAOYSA-N buta-1,3-diene;styrene Chemical compound C=CC=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 FACXGONDLDSNOE-UHFFFAOYSA-N 0.000 abstract description 12
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- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 description 22
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 11
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 11
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 11
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 11
- 229940100243 oleanolic acid Drugs 0.000 description 11
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 11
- IBFYXTRXDNAPMM-BVTMAQQCSA-N Geniposide Chemical compound O([C@@H]1OC=C([C@@H]2[C@H]1C(=CC2)CO)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O IBFYXTRXDNAPMM-BVTMAQQCSA-N 0.000 description 10
- 239000003112 inhibitor Substances 0.000 description 6
- 239000002480 mineral oil Substances 0.000 description 6
- 235000010446 mineral oil Nutrition 0.000 description 6
- 230000003647 oxidation Effects 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- IOUQJTTZESSBKY-UHFFFAOYSA-L zinc N-butyl-N-sulfidosulfanylbutan-1-amine formate Chemical group C(=O)[O-].C(CCC)N(SS[Zn+])CCCC IOUQJTTZESSBKY-UHFFFAOYSA-L 0.000 description 6
- 239000004593 Epoxy Substances 0.000 description 4
- 239000011505 plaster Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000011068 loading method Methods 0.000 description 3
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- YREYLAVBNPACJM-UHFFFAOYSA-N 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol Chemical compound CC(C)(C)NCC(O)C1=CC=CC=C1Cl YREYLAVBNPACJM-UHFFFAOYSA-N 0.000 description 2
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Abstract
The invention relates to a styrene-series hot-melt pressure-sensitive adhesive and a preparation method, and belongs to the technical field of hot-melt pressure-sensitive adhesive. The styrene-series hot-melt pressure-sensitive adhesive is characterized in that a polar group is introduced to a styrene-series thermoplastic elastomer molecule and a polar regulator is matched, so that the lipotropism characteristic of the traditional styrene-series thermoplastic elastomer-based hot-melt pressure-sensitive adhesive matrix is changed; and at the same time, the adhesion performance of the system is regulated by adopting un-modified styrene-isoprene-styrene block polymer or styrene-butadiene-styrene block polymer resin, thus the pressure-sensitive performance loss caused by introduction of the polar group is compensated. The styrene-series hot-melt pressure-sensitive adhesive has the effects and benefits that the advantages of the styrene-series thermoplastic elastomer-based hot-melt pressure-sensitive adhesive are retained; and the formed system has release passages capable of satisfying different medicament requirements, and is an ideal matrix material for preparing plasters for percutaneous administration.
Description
Technical field
The invention belongs to the hot-fusible pressure-sensitive adhesive technical field, relate to a kind of medicine patch polystyrene thermoplastic elastomer base hot-fusible pressure-sensitive adhesive matrix and preparation method.
Background technology
Transdermal delivery system makes medicine enter the body circulation with nearly constant rate of speed by skin by the skin surface administration, produces whole body or local therapeutic effects.It can avoid oral bring do not accommodate liver first-pass effect; Can overcome because absorbing the too high untoward reaction that causes of too fast generation Plasma Concentration; Administration is flexible, steady, controlled, is not subjected to the influence of factors such as pH value, food in the digestive tube.It mainly is made up of matrix and medicine two portions, and matrix is the goods and materials carrier of percutaneous dosing, determines outward appearance, sticking performance and the transdermal effect of drug delivery system.
In the various kinds of drug patch substrate, be that the hot-fusible pressure-sensitive adhesive matrix of skeleton just progressively replaces or replace solvents type or aq. type sizing agent with the polystyrene thermoplastic elastomer, become one of fastest-rising sizing agent kind, reason is that such matrix has the incomparable advantage of other systems: contain a small amount of or do not have the chemical functional group, can reduce the effect between medicine and the matrix; When contacting with some alcoholic medicines, be difficult for swelling; As percutaneous dosing goods and materials carrier, its modulus is low, cementability is strong, pungency is little, drug loading is high, and its pressure-sensitive gives the transdermal administration patch very big handiness, can apply ointment or plaster at any time or removes subsides according to the sufferer situation, and can be repeatedly used; It not with an organic solvent, does not have environmental pollution in preparation and the course of processing, the production efficiency height is fit to plurality of advantages such as automatic production.
At present, in the medicine patch field, the polymkeric substance of producing and using mainly is the polystyrene thermoplastic elastomer, comprises styrene-butadiene-styrene block copolymer (SBS), styrene isoprene styrene block copolymer (SIS) (SIS) and their hydrogenation modified form segmented copolymer (SEBS, SEPS).They itself do not have pressure-sensitive characteristic, increase auxiliary agents such as sticking resin and but can give the system pressure-sensitive character by the microcosmic phase structure and the rheologic behavio(u)r that change the segmented copolymer base material.As the material carrier of medicine patch, medicine dissolution or be dispersed in the polystyrene thermoplastic elastomer skeleton, by the release of polymer backbone control medicine, the consistency between medicine and the polymkeric substance plays a crucial role to the release of medicine.The nonpolar characteristics of polystyrene thermoplastic elastomer base hot-fusible pressure-sensitive adhesive are conducive to lipophilic drugs and discharge, but and be not suitable for low lipophilic drugs and hydrophilic medicament, for the compound medicine that contains low lipophilic composition and hydrophilic composition, inapplicable equally.Therefore, their application mainly concentrates on the former, as, Chinese patent 200510029757.4 discloses a kind of prescription and preparation method of SIS hot-fusible pressure-sensitive adhesive, and this hot-fusible pressure-sensitive adhesive is used for the ointment preparation, the transdermal administration plaster drug loading that makes is big, strong drug action.But traditional SIS hot-fusible pressure-sensitive adhesive has hydrophobicity, is unfavorable for the release of hydrophilic medicament, and has the medicine of a great deal of to belong to hydrophilic medicament, thereby present SIS hot-fusible pressure-sensitive adhesive matrix can not satisfy the requirement of hydrophilic medicament percutaneous dosing.Chinese patent 200410015623.2 discloses a kind of thermoplastic elastomer base hot-fusible pressure-sensitive adhesive patch that contains wetting ability tulobuterol medicine; although the thermoplastic elastomer that will protect in its claims comprises styrene-isoprene-phenylethene (SIS); or styrene-butadiene-styrene (SBS); SIS/SBS hydride; or a kind of in the urethane; but; in the embodiment of this patent; do not provide any SIS; or SBS; or the embodiment of SIS/SBS hydride, also can be at SIS without any evidence surface hydrophilicity medicine tulobuterol; or SBS; or realize in a kind of hot-fusible pressure-sensitive adhesive in the SIS/SBS hydride effectively discharging.
Summary of the invention
Purpose of the present invention just provides a kind of polystyrene thermoplastic elastomer base hot-fusible pressure-sensitive adhesive, makes it satisfy the percutaneous dosing requirement of different pharmaceutical.
The present invention is at first by introducing polar group in the diolefine segments of approach in SIS or SBS such as maleic anhydride graft reaction or epoxidation reaction, obtain polarity S IS resin (PSIS) or SBS resin (PSBS), the mol ratio of the unsaturated double-bond of diolefine segment is between 0.5%～50% in the introducing amount of its polar monomer and the styrene block copolymer.With above-mentioned polar styrene block copolymer and not the mixture of polar styrene block copolymer be matrix, be equipped with compositions such as tackifying resin, softening agent, oxidation inhibitor and prepare the polystyrene hot-fusible pressure-sensitive adhesive; Introduce polar modifier by the method for physical blending again, with the Release Performance of improvement system to hydrophilic medicament.
Polystyrene hot-fusible pressure-sensitive adhesive provided by the invention comprises following main component:
(a) the styrene block copolymer composition of 30-200 parts by weight, described styrene block copolymer composition comprises SIS/PSIS, SIS/PSBS, SBS/PSIS and SBS/PSBS, the weight ratio of two components is in 0.25～4.0 scope.
(b) tackifier of 50-100 parts by weight, described tackifier are selected from petroleum resin, terpine resin, rosin or its composition.
(c) softening agent of 20-60 parts by weight, described softening agent are selected from mineral oil, whiteruss, white oil or its composition.
(d) oxidation inhibitor of 0.5-3.0 parts by weight, described oxidation inhibitor is selected from N, N-dibutylamino dithio zinc formate, rubber accelerator or its composition.
(e) polar modifier of 40-70 parts by weight, described polar modifier are that polyoxyethylene glycol resin, polymethacrylate, polyacrylic ester or other can have with epoxide group, maleic anhydride group and pretend polar polymer firmly.
The preferred polar degree of wherein said polarity thermoplastic elastomer is at 5%-25%, the preferred 80-120 parts by weight of usage quantity, the preferred 80-90 parts by weight of described tackifier, the preferred 35-45 parts by weight of described softening agent, the preferred 1-2 parts by weight of described oxidation inhibitor, the preferred 50-60 parts by weight of described polar modifier.
Polystyrene hot-fusible pressure-sensitive adhesive system provided by the invention, its preparation method comprises step:
A) be full of N
2Encloses container in, preparation styrene block copolymer composition under ° C temperature of 150 ° of C～190;
B) be full of N
2Encloses container in, with above-mentioned styrene block copolymer composition 80～120 parts by weight under ° C temperature of 130 ° of C～170 with 1～2 parts by weight oxidation inhibitor, 35～45 parts by weight softening agent and 80～90 parts by weight tackifier melting mixing, preparation styrene block copolymer hot-fusible pressure-sensitive adhesive;
C) in above-mentioned system, add 50～60 parts by weight polar modifiers, improve the polarity of system, obtain the composite hot melt pressure sensitive adhesive.
Above-mentioned polystyrene hot-fusible pressure-sensitive adhesive is during for the preparation of the main body of transdermal delivery system, and also comprise following composition: 1) the transdermal infiltration accelerating agent of 5-10 parts by weight, described transdermal infiltration accelerating agent are ethanol, propylene glycol or its composition.2) 5-10 parts of medicines by weight, described medicine are to satisfy the one-component medicine of transdermal administration requirement or the compound of multicomponent pharmaceutical.The preferred 6-8 parts by weight of described medicine, the preferred 6-8 parts by weight of described transdermal infiltration accelerating agent.
The preparation method of the main body of polystyrene hot-fusible pressure-sensitive adhesive base transdermal delivery system provided by the invention comprises step:
A) be full of N
2Encloses container in, preparation styrene block copolymer composition under ° C temperature of 150 ° of C～190.With above-mentioned styrene block copolymer composition 80～120 parts by weight under ° C temperature of 130 ° of C～170 with 1～2 parts by weight oxidation inhibitor, 35～45 parts by weight softening agent and 80～90 parts by weight tackifier melting mixing, preparation styrene block copolymer hot-fusible pressure-sensitive adhesive.In above-mentioned system, add 50～60 parts by weight polar modifiers, improve the polarity of system, obtain the composite hot melt pressure sensitive adhesive.
B) 6～8 parts by weight medicines and 6～8 parts by weight infiltration accelerating agents are sneaked in the above-mentioned hot-fusible pressure-sensitive adhesive hot-fusible pressure-sensitive adhesive matrix of preparation pastille under 110 ° of C temperature condition;
C) contain medicine plaster preparation: under 110 ℃, by the heat seeling coating machine pastille hot-fusible pressure-sensitive adhesive of above-mentioned preparation being coated on thickness is that coating thickness 120 ± 20 μ m cover back lining materials after cooling, namely get the hot-fusible pressure-sensitive adhesive paster on the polyester film about 100um.
The present invention to made paster with adhesion property and the medicine-releasing performance judgement criteria as pressure sensitive adhesive characteristic.Adhesion property comprises holds viscosity energy and stripping strength, adopts the test of national standard (GB/T4851-1998) and national standard (GB2792-81) respectively.
Medicine-releasing performance is measured: the aqueous ethanolic solution with 40% is the receiver media of drug release, carries out drug release test, gets the medicine plaster that contains of preparation, removes the paster protective membrane, and medicated layer is towards reception tank, diffusion area 0.627cm
2, reception tank volume 5ml; Guarantee 37 ± 0.5 ℃ of reception tank temperature, stirring velocity 700r/min.Pick up counting, respectively at 1,3,6,9,12h gets sample 0.4ml in the reception tank, replenishes the blank receiver media of equality of temperature equivalent simultaneously, three groups of parallel laboratory tests are adopted in each test at least.
Record drug concentrations according to liquid chromatograph, by formula (1) and (2), calculate the cumulative release rate Q of different time sections medicine,
M
t: unit surface cumulative release amount;
M
∞: the drug loading in the unit surface patch;
V: it is long-pending to receive liquid;
A: diffusion cell open area;
C
n: the concentration of n sub-sampling.
Effect of the present invention and benefit are the advantages that not only can keep polystyrene thermoplastic elastomer base hot-fusible pressure-sensitive adhesive, and formed system has the release channel that satisfies the different pharmaceutical requirement, are the ideal basis materials of preparation medicine percutaneous administration patch.
Description of drawings
Fig. 1 is the releasing curve diagram of jasminoidin in hot-fusible pressure-sensitive adhesive.
Fig. 2 is the releasing curve diagram of Oleanolic Acid in hot-fusible pressure-sensitive adhesive.
Embodiment
Be described in detail specific embodiments of the invention below in conjunction with technical scheme and accompanying drawing.
Embodiment 1
Test is in contrast directly used there be not modification SIS resin 80～120 parts by weight being full of N
2～150 ° of C encloses containers in 1～2 parts by weight N, N-dibutylamino dithio zinc formate, 35～45 parts by weight mineral oil and 80～90 parts by weight petroleum resin, 50～60 parts by weight polyoxyethylene glycol resin melting mixing, preparation styrene block copolymer hot-fusible pressure-sensitive adhesive, its adhesion property is seen attached list.
The adhesion property of subordinate list embodiment hot-fusible pressure-sensitive adhesive
6～8 parts by weight hydrophilic medicament jasminoidins (or lipophilic drugs Oleanolic Acid) and 6～8 parts by weight propylene glycol are sneaked in the above-mentioned hot-fusible pressure-sensitive adhesive hot-fusible pressure-sensitive adhesive matrix of preparation pastille under 110 ° of C temperature condition; Under 110 ℃, by the heat seeling coating machine above-mentioned pastille hot-fusible pressure-sensitive adhesive being coated on thickness is that coating thickness 120 ± 20 μ m cover back lining materials after cooling, namely get the hot-fusible pressure-sensitive adhesive paster on the polyester film about 100um.The accumulative total release rate of hydrophilic medicament jasminoidin and lipophilic drugs Oleanolic Acid is seen Fig. 1 and Fig. 2 respectively.
Be full of N
2～170 ° of C encloses containers in, be about 5% SIS resin with epoxy content and do not have modification SIS resin by 1:1 weight ratio melting mixing; Above-mentioned composition 80～120 parts by weight are being full of N
2～150 ° of C encloses containers in 1～2 parts by weight N, N-dibutylamino dithio zinc formate, 35～45 parts by weight mineral oil and 80～90 parts by weight petroleum resin, 50～60 parts by weight polyoxyethylene glycol resin melting mixing, preparation styrene block copolymer hot-fusible pressure-sensitive adhesive, its adhesion property is seen attached list; 6～8 parts by weight medicines (hydrophilic medicament jasminoidin or lipophilic drugs Oleanolic Acid) and 6～8 parts by weight propylene glycol are sneaked in the above-mentioned hot-fusible pressure-sensitive adhesive hot-fusible pressure-sensitive adhesive matrix of preparation pastille under 110 ° of C temperature condition; Under 110 ℃, by the heat seeling coating machine above-mentioned pastille hot-fusible pressure-sensitive adhesive being coated on thickness is that coating thickness 120 ± 20 μ m cover back lining materials after cooling, namely get the hot-fusible pressure-sensitive adhesive paster on the polyester film about 100um.The accumulative total release rate of hydrophilic medicament jasminoidin and lipophilic drugs Oleanolic Acid is seen Fig. 1 and Fig. 2 respectively.
Embodiment 3
Be full of N
2～170 ° of C encloses containers in, epoxy content is about 10% SIS resin and do not have modification SIS resin by 1:1 weight ratio melting mixing; Above-mentioned composition 80～120 parts by weight are being full of N
2～150 ° of C encloses containers in 1～2 parts by weight N, N-dibutylamino dithio zinc formate, 35～45 parts by weight mineral oil and 80～90 parts by weight petroleum resin, 50～60 parts by weight polyoxyethylene glycol resin melting mixing, preparation styrene block copolymer hot-fusible pressure-sensitive adhesive, its adhesion property is seen attached list; 6～8 parts by weight medicines (hydrophilic medicament jasminoidin or lipophilic drugs Oleanolic Acid) and 6～8 parts by weight propylene glycol are sneaked in the above-mentioned hot-fusible pressure-sensitive adhesive hot-fusible pressure-sensitive adhesive matrix of preparation pastille under 110 ° of C temperature condition; Under 110 ℃, by the heat seeling coating machine above-mentioned pastille hot-fusible pressure-sensitive adhesive being coated on thickness is that coating thickness 120 ± 20 μ m cover back lining materials after cooling, namely get the hot-fusible pressure-sensitive adhesive paster on the polyester film about 100um.The accumulative total release rate of hydrophilic medicament jasminoidin and lipophilic drugs Oleanolic Acid is seen Fig. 1 and Fig. 2 respectively.
Be full of N
2～170 ° of C encloses containers in, epoxy content is about 10% SBS resin and do not have modification SIS resin by 1:1 weight ratio melting mixing; Above-mentioned composition 80～120 parts by weight are being full of N
2～150 ° of C encloses containers in 1～2 parts by weight N, N-dibutylamino dithio zinc formate, 35～45 parts by weight mineral oil and 80～90 parts by weight petroleum resin, 50～60 parts by weight polyoxyethylene glycol resin melting mixing, preparation styrene block copolymer hot-fusible pressure-sensitive adhesive, its adhesion property is seen attached list; 6～8 parts by weight medicines (hydrophilic medicament jasminoidin or lipophilic drugs Oleanolic Acid) and 6～8 parts by weight propylene glycol are sneaked in the above-mentioned hot-fusible pressure-sensitive adhesive hot-fusible pressure-sensitive adhesive matrix of preparation pastille under 110 ° of C temperature condition; Under 110 ℃, by the heat seeling coating machine above-mentioned pastille hot-fusible pressure-sensitive adhesive being coated on thickness is that coating thickness 120 ± 20 μ m cover back lining materials after cooling, namely get the hot-fusible pressure-sensitive adhesive paster on the polyester film about 100um.The accumulative total release rate of hydrophilic medicament jasminoidin and lipophilic drugs Oleanolic Acid is seen Fig. 1 and Fig. 2 respectively.
Embodiment 5
Be full of N
2～170 ° of C encloses containers in, epoxy content is about 10% SIS resin and do not have the modified SBS resin by 1:1 weight ratio melting mixing; Above-mentioned composition 80～120 parts by weight are being full of N
2～150 ° of C encloses containers in 1～2 parts by weight N, N-dibutylamino dithio zinc formate, 35～45 parts by weight mineral oil and 80～90 parts by weight petroleum resin, 50～60 parts by weight polyoxyethylene glycol resin melting mixing, preparation styrene block copolymer hot-fusible pressure-sensitive adhesive, its adhesion property is seen attached list; 6～8 parts by weight medicines (hydrophilic medicament jasminoidin or lipophilic drugs Oleanolic Acid) and 6～8 parts by weight propylene glycol are sneaked in the above-mentioned hot-fusible pressure-sensitive adhesive hot-fusible pressure-sensitive adhesive matrix of preparation pastille under 110 ° of C temperature condition; Under 110 ℃, by the heat seeling coating machine above-mentioned pastille hot-fusible pressure-sensitive adhesive being coated on thickness is that coating thickness 120 ± 20 μ m cover back lining materials after cooling, namely get the hot-fusible pressure-sensitive adhesive paster on the polyester film about 100um.The accumulative total release rate of hydrophilic medicament jasminoidin and lipophilic drugs Oleanolic Acid is seen Fig. 1 and Fig. 2 respectively.
Claims (5)
1. polystyrene hot-fusible pressure-sensitive adhesive, its composition comprises styrene block copolymer composition, tackifier, softening agent, rubber accelerator and polar modifier, it is characterized in that, the parts by weight of each component are:
Described styrene block copolymer composition comprises SIS/PSIS, SIS/PSBS, SBS/PSIS and SBS/PSBS, and the weight ratio of two components is in 0.25～4.0 scope in the composition; Wherein, PSIS and PSBS are respectively SIS, SBS by the product of maleic anhydride graft reaction or epoxidation reaction modification, and the mol ratio of the unsaturated double-bond of diolefine segment is between 0.5%～50% in the introducing amount of its polar monomer and the styrene block copolymer.
2. polystyrene hot-fusible pressure-sensitive adhesive according to claim 1 is characterized in that, described tackifier are selected from petroleum resin, terpine resin, rosin or its composition; Described softening agent is selected from whiteruss, white oil or its composition; Described polar modifier is selected from polyoxyethylene glycol resin, polymethacrylate, polyacrylic ester or other can be had with epoxide group, maleic anhydride group and pretend polar polymer firmly.
3. claim 1 or 2 described polystyrene hot-fusible pressure-sensitive adhesives, its preparation method comprises the steps:
1) is being full of N
2Encloses container in, 150
oC～190
oPreparation styrene block copolymer composition under the C temperature; Styrene block copolymer composition, tackifier, softening agent, rubber accelerator are mixed preparation styrene block copolymer hot-fusible pressure-sensitive adhesive by described component melts;
2) in above-mentioned system, add polar modifier in proportion, improve the polarity of system, obtain the polystyrene hot-fusible pressure-sensitive adhesive.
4. polystyrene hot-fusible pressure-sensitive adhesive according to claim 1 and 2 is characterized in that, is used for the substrate material of medicine percutaneous dosing, with transdermal infiltration accelerating agent, medicament mixed, constitutes the main body of transdermal delivery system; Described transdermal infiltration accelerating agent is ethanol, propylene glycol or its composition; Described medicine is to satisfy the one-component medicine of transdermal administration requirement or the compound of multicomponent pharmaceutical.
5. the described polystyrene hot-fusible pressure-sensitive adhesive of claim 4, wherein the preparation method of the main body of transdermal delivery system comprises the steps:
A) be full of N
2Encloses container in, 150
oC～190
oPreparation styrene block copolymer composition under the C temperature;
B) be full of N
2Encloses container in, with above-mentioned styrene block copolymer composition 40～50 parts by weight 130
oC～170
oWith 1～2 parts by weight rubber accelerator, 35～45 parts by weight softening agent and 80～90 parts by weight tackifier melting mixing, prepare the styrene block copolymer hot-fusible pressure-sensitive adhesive under the C temperature;
C) in above-mentioned system, add 50～60 parts by weight polar modifiers, improve the polarity of system, obtain the composite hot melt pressure sensitive adhesive;
D) with 6～8 parts by weight medicines and 6～8 parts by weight transdermal infiltration accelerating agents 110
oSneak in the above-mentioned hot-fusible pressure-sensitive adhesive preparation pastille hot-fusible pressure-sensitive adhesive under the C temperature condition;
E) under 110 ℃, be coated on the polyester film that thickness is 100 μ m by the pastille hot-fusible pressure-sensitive adhesive of heat seeling coating machine with above-mentioned preparation, coating thickness 120 ± 20 μ m cover back lining materials after cooling.
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| KR20070048229A (en) * | 2004-08-05 | 2007-05-08 | 코리움 인터네셔널, 인크. | Adhesive composition |
| CN101711754A (en) * | 2009-11-06 | 2010-05-26 | 河南省生物工程技术研究中心 | Tamoxifen citrate emplastrum and preparation method thereof |
| CN101899276B (en) * | 2010-07-31 | 2012-07-25 | 大连理工大学 | Amphiphilic hot-melt pressure sensitive adhesive and preparation method thereof |
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