CN102557527A - Temperature control magnetic bone cement and preparation method thereof - Google Patents

Temperature control magnetic bone cement and preparation method thereof Download PDF

Info

Publication number
CN102557527A
CN102557527A CN2012100007425A CN201210000742A CN102557527A CN 102557527 A CN102557527 A CN 102557527A CN 2012100007425 A CN2012100007425 A CN 2012100007425A CN 201210000742 A CN201210000742 A CN 201210000742A CN 102557527 A CN102557527 A CN 102557527A
Authority
CN
China
Prior art keywords
bone cement
preparation
manganese
temperature
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2012100007425A
Other languages
Chinese (zh)
Other versions
CN102557527B (en
Inventor
李光大
赵三团
胡志刚
马建华
乔晓岚
谢蟪旭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henan University of Science and Technology
Original Assignee
Henan University of Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henan University of Science and Technology filed Critical Henan University of Science and Technology
Priority to CN 201210000742 priority Critical patent/CN102557527B/en
Publication of CN102557527A publication Critical patent/CN102557527A/en
Application granted granted Critical
Publication of CN102557527B publication Critical patent/CN102557527B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Materials For Medical Uses (AREA)

Abstract

The invention relates to temperature control magnetic bone cement and a preparation method thereof. The preparation method comprises the following steps: weighing FeCl3 6H2O, ZnCl2 and MnCl2 4H2O, mixing the materials according to the stoichiometric ratio of Mn0.15Zn0.85Fe2O4, adding ultra-pure water for preparing a solution, reacting, then getting a precursor of a manganese-zinc ferrite, calcining the precursor of the manganese-zinc ferrite to get manganese-zinc ferrite powder, adding a spherical poly(methyl methacrylate) particle powder agent containing benzoyl peroxide into the manganese-zinc ferrite powder, uniformly mixing, further adding methyl methacrylate containing dimethyl mercaptopropionic acid, and blending to prepare a product. The Curie temperature of the bone cement prepared by the preparation method disclosed by the invention is about 50 DEG C, the magnetic bone cement containing the manganese-zinc ferrite in the different proportions can raise the temperature from 37 DEG C to 50 DEG C and be constant at the temperature under an external alternating magnetic field, and the temperature control performance is realized.

Description

A kind of temperature control magnetic bone cement and preparation method
Technical field
The present invention relates to a kind of bio-medical material, a kind of specifically temperature control magnetic bone cement and preparation method.
Background technology
The postoperative recurrence problem of bone tumor is a great problem of puzzlement medical circle.Bone tumor recurrence not only makes the patient stand more misery, but life-threatening very.Because the recurrence problem of bone tumor, people have proposed the requirement of oncotherapy function to the bone renovating material that originally has only bone repair and reconstruction function.Bone cement is a kind of by clinical widely used orthopaedics repair materials, and by solid phase and liquid-phase mixing, having can clinical any figuration as the one of which, handiness, advantage such as performance is good.
The magnetic thermotherapy utilizes magnetic under alternating magnetic field, can the externally-applied magnetic field energy transformation be become the characteristics of heat energy; The magneticinduction dielectric material is fitted the tumor locus that the patient was implanted or imported to shape; Add suitable alternating magnetic field, can heat tumor area, (cancer cells is will be dead more than 42 ℃ to utilize tumour cell and the tissue characteristics more responsive to heat than normal cell and tissue; But and about normal cell heat resistanceheat resistant to 48 ℃), reach the purpose of high magnetic target therapy.Characteristics such as the magneticinduction thermotherapy has simple to operate, and is with low cost, safe, and spinoff is little, and the magneticinduction medium can repeat repeatedly thermotherapy once implantation, so be particularly suitable for treating the bone tumor that is in the health depths.And develop the bone cement with magnetic is a hot research direction of orthopaedics material.
In magnetic thermotherapy process, the control of the temperature of therapeutic area is most important.If Heating temperature is crossed the low purpose that can not have thermotherapy, and if temperature is too high, will be heated to normal tissue, cause that muscle or nerve etc. are organized overheated necrosis normally on the next door.So when thermotherapy, realize the control of thermotherapy temperature, could be security and the validity of guaranteeing to treat.Wherein overheated is a phenomenon that must prevent.But the present magnetic bone cement material of studying does not nearly all design function of temperature control.In the reality use, just need to use other temperature control unit that temperature is carried out measurement and control, complex operation.
As far as magneticsubstance, can there be the Tc characteristic, the magnetic of material disappears when temperature is higher than Tc, and no longer can the magneticinduction heating.But magnetize induced material almost is Z 250 entirely in the magnetic bone cement of exploitation at present; Though Z 250 has higher magnetic heat generation ability; But its Tc is very high, has reached about 590 ℃, is that the bone cement of magnetic crystalline phase is very easy to superheated with the Z 250.
Summary of the invention
The present invention provides a kind of temperature control magnetic bone cement and preparation method thereof for solving the existing easy superheated problem of magnetic bone cement, and this bone cement has the good cell consistency; About 50 ℃ of Tc, when temperature reached 50 ℃, material promptly stopped heating; And temperature can realize heating once again when being lower than this temperature; Guarantee optimal temperature, prevent simultaneously in the thermotherapy process superheat to take place, improve the security of magnetic thermotherapy.
The present invention solves the problems of the technologies described above the technical scheme of employing to be: a kind of temperature control magnetic bone cement and preparation method comprise following steps:
One) preparation of Mn-Zn ferrite
1) takes by weighing FeCl respectively 36H 2O, ZnCl 2And MnCl 24H 2O also presses Mn 0.15Zn 0.85Fe 2O 4Stoichiometric ratio batching, add ultrapure water, be made into the solution that concentration of metal ions is 0.3mol/L, under 90 ℃ constant temperature, react 4h;
In the reaction process, the NaOH solution that under the stirring velocity of 3000rpm, drips concentration in the solution and be 1mol/L is 10 with the pH value of control reaction soln;
2) deposition that reaction back in the step 1 is produced is washed and spinning under the 6000rpm rotating speed with ultrapure water, dries under the condition that is deposited in 60 ℃ of temperature, pressure 0.09-0.093MPa after the separation, obtains the Mn-Zn ferrite presoma, and is subsequent use;
3) the Mn-Zn ferrite presoma that is obtained is calcined 1h under the condition of 450 ℃ of temperature, pressure 0.09-0.093MPa, promptly obtain manganese-zinc-ferrite powder;
The preparation of two) temperature control magnetic bone cement
4) preparation of bone cement matrix:
Get spherical poly methyl methacrylate particle pulvis, after screening, choose granularity, add benzoyl peroxide then therein, mix and make solid phase bone cement matrix less than the spherical poly methyl methacrylate particle pulvis of 200 purposes, subsequent use;
The molecular-weight average of described spherical polymethylmethacrylate is 270kDa;
The add-on of described benzoyl peroxide is 4 % of solid phase bone cement matrix gross weight;
Other gets MMA MONOMER, adds therein to make liquid phase bone cement matrix after dimethyl sulphoniopropionate mixes;
The add-on of described dimethyl sulphoniopropionate is 2 % of liquid phase bone cement matrix gross weight;
5) get the manganese-zinc-ferrite powder that makes in the step 3 and join in the bone cement solid-phase matrix in the step 4 and mix, make the bone cement compound; Be that the ratio of 1:1 adds the bone cement liquid matrix in the step 4 in the bone cement compound according to weight ratio then, use stainless steel knife to be in harmonious proportion 3min then and promptly make product;
Wherein, the add-on of manganese-zinc-ferrite powder is the 40%-60% of the finished product gross weight.
Among the present invention, FeCl 36H 2O, ZnCl 2And MnCl 24H 2When O reacts, can cause the variation of pH value of solution value in solution, therefore need dropping sodium solution to make its pH value stabilization 10.
Among the present invention, the heat-up rate when the Mn-Zn ferrite presoma that makes is calcined is 5 ℃/min.
Beneficial effect: polymethylmethacrylate is widely used clinically at present bone cement, and molecular formula is mixed in this research in polymethylmethacrylate be Mn 0.15Zn 0.85Fe 2O 4Mn-Zn ferrite, but the preparation temperature control the magnetic bone cement.Research shows this bone cement set time about 10-25min, meets clinically the requirement to bone cement curing operation time 8-30min; Ultimate compression strength is about 83.6-98Mpa, and is approaching with the ultimate compression strength of cortex bone; The MTT experiment shows that material has the good cell consistency; The about 50 ° of C of the Tc of Tc test shows material; All can realize being warmed up to 50 ° of C adding the magnetic bone cement that contains the different ratios Mn-Zn ferrite under the alternating magnetic field from 37 ° of C; And in time increase continue not to heat up, but constant in this temperature, has realized temperature-control performance.The experimental study of Akihiko Matsumine etc. shows that when the magneticsubstance temperature reached 50 ° of C, the temperature that can make the osseous tissue surface was to reach about the effective 43 ° of C of thermotherapy, and organizing around can not making again simultaneously is influenced.It is similar with it that the material magnetic heat generation of this research detects magneticstrength, and the Tc of material is about 50 ° of C, can have beneficial effect so the reply of the material of this research and design realizes temperature control thermotherapy treatment bone tumor.
Embodiment
Below in conjunction with specific embodiment the present invention is done further elaboration.
Embodiment 1
A kind of temperature control magnetic bone cement, its preparation process is following:
One) preparation of Mn-Zn ferrite
1) takes by weighing FeCl respectively 36H 2O, ZnCl 2And MnCl 24H 2O also presses Mn 0.15Zn 0.85Fe 2O 4Stoichiometric ratio batching, add ultrapure water, be made into the solution that concentration of metal ions is 0.3mol/L, under 90 ℃ constant temperature, react 4h;
In the reaction process, the NaOH solution that under the stirring velocity of 3000rpm, drips concentration in the solution and be 1mol/L is 10 with the pH value of control reaction soln;
2) deposition that reaction back in the step 1 is produced is washed and spinning under the 6000rpm rotating speed with ultrapure water, dries under the condition that is deposited in 60 ℃ of temperature, pressure 0.09-0.093MPa after the separation, obtains the Mn-Zn ferrite presoma, and is subsequent use;
3) the Mn-Zn ferrite presoma that is obtained is calcined 1h under the condition of 450 ℃ of temperature, pressure 0.09-0.093MPa, promptly obtain manganese-zinc-ferrite powder;
The preparation of two) temperature control magnetic bone cement
4) preparation of bone cement matrix:
Get spherical poly methyl methacrylate particle pulvis, after screening, choose granularity, add benzoyl peroxide then therein, mix and make solid phase bone cement matrix less than the spherical poly methyl methacrylate particle pulvis of 200 purposes, subsequent use;
The molecular-weight average of described spherical polymethylmethacrylate is 270kDa;
The add-on of described benzoyl peroxide is 4 % of solid phase bone cement matrix gross weight;
Other gets MMA MONOMER, adds therein to make liquid phase bone cement matrix after dimethyl sulphoniopropionate mixes;
The add-on of described dimethyl sulphoniopropionate is 2 % of liquid phase bone cement matrix gross weight;
5) get the manganese-zinc-ferrite powder that makes in the step 3 and join in the bone cement solid-phase matrix in the step 4 and mix, make the bone cement compound; Be that the ratio of 1:1 adds the bone cement liquid matrix in the step 4 in the bone cement compound according to weight ratio then, use stainless steel knife to be in harmonious proportion 3min then and promptly make product;
Wherein, the add-on of manganese-zinc-ferrite powder is 50% of a finished product gross weight.
Get the temperature control magnetic bone cement that makes, check its each item index method following:
One, set time;
After getting solid phase powder and liquid phase stirring 3min, move in Ф 9 * 5mm mould, flatten; Place relative humidity 100%; In 37 ℃ of thermostat containers, the 400N load down, with the needle point diameter stainless steel pinprick concrete column face that is 1mm, stop to move down to load and be the cement solidification time.Get 5 appearance, average.
Two, ultimate compression strength;
After getting solid phase powder and liquid phase stirring 3min; Sample is processed the smooth cylindric sample of Ф 4 * 8mm in two ends; Treat after the sample solidifies its maintenance 72h in 37 ℃ of thermostat containers of relative humidity 100%; Use its ultimate compression strength of SHIMADZU SES-1000 test, load 900N, pressing speed 1mm/min.Choose 5 harmless samples, test its MV for every group.
Three, crystalline phase is formed;
Material is worn into fine powder, and (X'Pert Pro MPD X Philips) detects its crystalline phase and forms 0.06 °/s of scanning step to adopt X crystalline phase diffractometer.
Four, magnetic test and magnetic heating performance detect;
Material is worn into the pillar of 3 millimeters of long 6 millimeters, diameters, use vibrating sample magnetometer (Lake shore7410) to detect its magnetic; Material is processed the cylinder of Ф 9 * 9mm, before curing, insert glass-stem thermometer, after waiting to solidify material is placed radio-frequency induction coil, frequency 100kHz, magnetic field size 25K Am -1, temperature of every 5min record is tested its in time heating curve under alternating magnetic field, observes its intensification ability.
Five, the mensuration of material Tc;
Adopt falling temperature method to measure the Tc of material.Sample is placed even cooling system, let it lower the temperature adding magnetic field and do not add under the situation in magnetic field respectively, note the cooling curve of sample, 2 pairing temperature of curve separation point can be considered sample Tc roughly.
Six, cytotoxicity test;
With material with 37 ° of C oxirane disinfections; The mass volume ratio (mg/mL) of material with 200:1 added in the nutrient solution of LG-DMEM, 37 ° of C are hatched 24 h, with above-mentioned suspension liquid high speed centrifugation again; Supernatant is with the filter paper filtering sterilization of 0.22 um; With hydrochloric acid soln adjustment pH value to 7.4 ± 0.5 of 0.1 M, the vat liquor that obtains adds 10% FBS as initial vat liquor, the cell experiment after being used for after initial vat liquor is diluted 2 times by the GM nutrient solution; (density is 5 * 10 to cell inoculation to get the most vigorous third generation cell ROS17/2.8 (rat bone sarcoma skeletonization like cell) of growth after the recovery 4Individual/ml) in 24 well culture plates, the original nutrient solution of sucking-off behind the 24 h cell attachments, vat liquor 200 uL that add corresponding dilution number replace, with the GM nutrient solution as control group; Behind cell cultures ld, 3d and the 5d, 1,3,5d respectively gets a culture plate and add MTT solution (5mg/ml) 40 μ l, 37 ° of C continue to cultivate 4h down; Stop cultivating, the careful suction abandoned culture supernatant liquid in the hole, and every hole adds 420 μ l DMSO; Vibration 10min fully dissolves crystallisate, draws in every hole liquid 200 μ l in 96 hole flat undersides; Select the 570nm wavelength then, on enzyme-linked immunosorbent assay instrument, measure each hole absorbance, the record result.Do 3 parallel appearance (P < 0.05).
Adopt aforesaid method to detect its performance to the temperature control magnetic bone cement that makes, the result is: be 12 ± 2min its set time, and mechanical strength is 98.1 ± 5.3Mpa, is expected to be used for weight bearing area bone repairing and treating; XRD studies demonstration, and the staple of material is polymethylmethacrylate and Mn-Zn ferrite; Use vibrating sample magnetometer to record material 1.59 * 10 6Am -1Saturation magnetization be 2.96Am 2Kg -1The Tc that falling temperature method records material is about 50 ° of C; At 100kHz, 25K Am -1Alternating magnetic field down can see that material has good intensification ability, on 37 ° of C basal temperatures, through about 25min; Material can be realized the intensification of 13 ° of C, reaches about 50 ° of C, reach this temperature after; The homo(io)thermism of material has embodied function of temperature control about 50 ° of C.Cell experiment shows that material has the good cell consistency.
Embodiment 2
The preparation of the preparation of Mn-Zn ferrite and bone cement matrix is all shown in embodiment 1.
Get manganese-zinc-ferrite powder and join in the bone cement solid-phase matrix and mix, make the bone cement compound; Be that the ratio of 1:1 adds the bone cement liquid matrix in the bone cement compound according to weight ratio then, use stainless steel knife to be in harmonious proportion 3min then and promptly make product;
Wherein, the add-on of manganese-zinc-ferrite powder is 40% of a finished product gross weight.
Adopt the experimental technique among the embodiment 1 to detect its performance to the temperature control magnetic bone cement that makes, the result is: recording its set time is 10 ± 1min, mechanics ultimate compression strength 91.1 ± 3.7Mpa; Use vibrating sample magnetometer to record material 1.59 * 10 6Am -1Saturation magnetization be 1.97Am 2Kg -1Under the basal temperature of 37 ° of C, under alternating magnetic field, can realize heating up, be stabilized at last about 50 ° of C; The MTT experiment shows that material has the good cell consistency.
Embodiment 3
The preparation of the preparation of Mn-Zn ferrite and bone cement matrix is all shown in embodiment 1.
Get manganese-zinc-ferrite powder and join in the bone cement solid-phase matrix and mix, make the bone cement compound; Be that the ratio of 1:1 adds the bone cement liquid matrix in the bone cement compound according to weight ratio then, use stainless steel knife to be in harmonious proportion 3min then and promptly make product;
Wherein, the add-on of manganese-zinc-ferrite powder is 60% of a finished product gross weight.
Adopt the experimental technique among the embodiment 1 to detect its performance to the temperature control magnetic bone cement that makes, the result is: recording its set time is 25 ± 2.5min, ultimate compression strength 83.6 ± 4.2Mpa; Use vibrating sample magnetometer to record material 1.59 * 10 6Am -1Saturation magnetization be 3.15Am 2Kg -1Under the basal temperature of 37 ° of C, under alternating magnetic field, can realize heating up, be stabilized at last about 50 ° of C; The MTT experiment shows that material has the good cell consistency.

Claims (1)

1. temperature control magnetic bone cement and preparation method is characterized in that, comprise following steps:
One) preparation of Mn-Zn ferrite
1) takes by weighing FeCl respectively 36H 2O, ZnCl 2And MnCl 24H 2O also presses Mn 0.15Zn 0.85Fe 2O 4Stoichiometric ratio batching, add ultrapure water, be made into the solution that concentration of metal ions is 0.3mol/L, under 90 ℃ constant temperature, react 4h;
In the reaction process, the NaOH solution that under the stirring velocity of 3000rpm, drips concentration in the solution and be 1mol/L is 10 with the pH value of control reaction soln;
2) deposition that reaction back in the step 1 is produced is washed and spinning under the 6000rpm rotating speed with ultrapure water, dries under the condition that is deposited in 60 ℃ of temperature, pressure 0.09-0.093MPa after the separation, obtains the Mn-Zn ferrite presoma, and is subsequent use;
3) the Mn-Zn ferrite presoma that is obtained is calcined 1h under the condition of 450 ℃ of temperature, pressure 0.09-0.093MPa, promptly obtain manganese-zinc-ferrite powder;
The preparation of two) temperature control magnetic bone cement
4) preparation of bone cement matrix:
Get spherical poly methyl methacrylate particle pulvis, after screening, choose granularity, add benzoyl peroxide then therein, mix and make solid phase bone cement matrix less than the spherical poly methyl methacrylate particle pulvis of 200 purposes, subsequent use;
The molecular-weight average of described spherical polymethylmethacrylate is 270kDa;
The add-on of described benzoyl peroxide is 4 % of solid phase bone cement matrix gross weight;
Other gets MMA MONOMER, adds therein to make liquid phase bone cement matrix after dimethyl sulphoniopropionate mixes;
The add-on of described dimethyl sulphoniopropionate is 2 % of liquid phase bone cement matrix gross weight;
5) get the manganese-zinc-ferrite powder that makes in the step 3 and join in the bone cement solid-phase matrix in the step 4 and mix, make bone cement solid phase mixing material; Be that the ratio of 1:1 adds the bone cement liquid matrix in the step 4 in bone cement solid phase mixing material according to weight ratio then, use stainless steel knife to be in harmonious proportion 3min then and promptly make product;
Wherein, the add-on of manganese-zinc-ferrite powder is the 40%-60% of the finished product gross weight.
CN 201210000742 2012-01-04 2012-01-04 Temperature control magnetic bone cement and preparation method thereof Expired - Fee Related CN102557527B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 201210000742 CN102557527B (en) 2012-01-04 2012-01-04 Temperature control magnetic bone cement and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 201210000742 CN102557527B (en) 2012-01-04 2012-01-04 Temperature control magnetic bone cement and preparation method thereof

Publications (2)

Publication Number Publication Date
CN102557527A true CN102557527A (en) 2012-07-11
CN102557527B CN102557527B (en) 2013-04-24

Family

ID=46404318

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 201210000742 Expired - Fee Related CN102557527B (en) 2012-01-04 2012-01-04 Temperature control magnetic bone cement and preparation method thereof

Country Status (1)

Country Link
CN (1) CN102557527B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104591293A (en) * 2014-12-24 2015-05-06 合肥协知行信息***工程有限公司 Preparation method of manganese zinc ferrite nanoparticles
CN106267330A (en) * 2016-08-29 2017-01-04 首都师范大学 A kind of bone cement with the high yield thermal efficiency
CN108129048A (en) * 2018-02-09 2018-06-08 河南科技大学 A kind of hot bone cement of temperature control magnetic being rapidly heated and preparation method thereof
CN110251724A (en) * 2019-06-28 2019-09-20 重庆医科大学附属第二医院 A kind of magnetic PMMA bone cement and its preparation method and application carrying adriamycin
CN110776266A (en) * 2019-11-07 2020-02-11 郑州大学 Preparation method of building material with electromagnetic wave absorption function
WO2022028035A1 (en) * 2020-08-03 2022-02-10 首都医科大学附属北京朝阳医院 Anti-myeloma nano-bone cement, preparation method therefor and use thereof
CN114404655A (en) * 2022-01-28 2022-04-29 洛阳市中医院 Porous scaffold with photo-thermal effect and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1595553A1 (en) * 2004-05-14 2005-11-16 Ceravic Polymeric cement for percutaneous vertebroplasty
CN101125219A (en) * 2007-09-04 2008-02-20 山东大学 Rapidly solidified calcium phosphate cement composite material and its preparation method
CN101530635A (en) * 2009-04-21 2009-09-16 上海交通大学医学院附属第九人民医院 Bioactive bone-repairing cement material

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1595553A1 (en) * 2004-05-14 2005-11-16 Ceravic Polymeric cement for percutaneous vertebroplasty
CN101125219A (en) * 2007-09-04 2008-02-20 山东大学 Rapidly solidified calcium phosphate cement composite material and its preparation method
CN101530635A (en) * 2009-04-21 2009-09-16 上海交通大学医学院附属第九人民医院 Bioactive bone-repairing cement material

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104591293A (en) * 2014-12-24 2015-05-06 合肥协知行信息***工程有限公司 Preparation method of manganese zinc ferrite nanoparticles
CN106267330A (en) * 2016-08-29 2017-01-04 首都师范大学 A kind of bone cement with the high yield thermal efficiency
CN108129048A (en) * 2018-02-09 2018-06-08 河南科技大学 A kind of hot bone cement of temperature control magnetic being rapidly heated and preparation method thereof
CN108129048B (en) * 2018-02-09 2020-06-23 河南科技大学 Temperature-controlled magnetic-thermal bone cement capable of rapidly increasing temperature and preparation method thereof
CN110251724A (en) * 2019-06-28 2019-09-20 重庆医科大学附属第二医院 A kind of magnetic PMMA bone cement and its preparation method and application carrying adriamycin
CN110776266A (en) * 2019-11-07 2020-02-11 郑州大学 Preparation method of building material with electromagnetic wave absorption function
WO2022028035A1 (en) * 2020-08-03 2022-02-10 首都医科大学附属北京朝阳医院 Anti-myeloma nano-bone cement, preparation method therefor and use thereof
CN114404655A (en) * 2022-01-28 2022-04-29 洛阳市中医院 Porous scaffold with photo-thermal effect and preparation method thereof
CN114404655B (en) * 2022-01-28 2022-12-20 洛阳市中医院 Porous scaffold with photo-thermal effect and preparation method thereof

Also Published As

Publication number Publication date
CN102557527B (en) 2013-04-24

Similar Documents

Publication Publication Date Title
CN102557527B (en) Temperature control magnetic bone cement and preparation method thereof
Chen et al. A simple sol-gel technique for synthesis of nanostructured hydroxyapatite, tricalcium phosphate and biphasic powders
CN103058645B (en) High-strength magnetic calcium-phosphate-based bone cement and preparation method thereof
Singh et al. Iron doped β-Tricalcium phosphate: Synthesis, characterization, hyperthermia effect, biocompatibility and mechanical evaluation
CN102671245A (en) Magnetic bone cement material and method for preparing magnetic bone cement
CN102824884A (en) TiO2/Fe2O3 composite hollow microsphere and preparation method thereof
Lu et al. Solvothermal Transformation of a Calcium Oleate Precursor into Large‐Sized Highly Ordered Arrays of Ultralong Hydroxyapatite Microtubes
Vecbiskena et al. Crystallized nano-sized alpha-tricalcium phosphate from amorphous calcium phosphate: microstructure, cementation and cell response
Tkachenko et al. Synthesis and properties of hybrid hydroxyapatite–ferrite (Fe 3 O 4) particles for hyperthermia applications
Lagno et al. Supersaturation-controlled synthesis of dicalcium phosphate dihydrate and nanocrystalline calcium-deficient hydroxyapatite
CN101716370A (en) Method for preparing nano doped hydroxylapatite powder
CN108358183A (en) Process for preparing tetracalcium phosphate
CN101462760A (en) Method for preparing high performance yttrium oxide material
Shao et al. 3D gel-printing of porous MgFe2O4 magnetic scaffolds for bone tissue engineering
CN110436529A (en) A kind of Fe can be used for magnetic thermotherapy3O4The preparation method of nano-bar material
CN106139253A (en) The compositions that can form composite bone cement and the bone cement formed by it
CN103951299A (en) Preparation method and application of magnesium phosphate cement
Abdel-Hameed et al. Magnetic glass ceramics for sustained 5-fluorouracil delivery: Characterization and evaluation of drug release kinetics
Yu et al. Solvothermal synthesis of hydroxyapatite with various morphologies using trimethyl phosphate as organic phosphorus source
CN110354313B (en) Magnetic reinforcing phase modified composite material and preparation method thereof
CN102320659B (en) Method for synthesizing lanthanum-vanadate nano material by adopting microwave-radiation method
CN105923617B (en) A kind of column magnetic hydroxylapatite nano material and preparation method thereof
CN107021520B (en) A kind of yttrium oxide powder and preparation method thereof
Bazin et al. Exotic FeII/FeIII local environments in the hexagonal channels of hydroxyapatite
CN108129048B (en) Temperature-controlled magnetic-thermal bone cement capable of rapidly increasing temperature and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130424

Termination date: 20140104