CN102526590B - Chinese medicament for improving IVF-ET post-implantation dysfunction - Google Patents
Chinese medicament for improving IVF-ET post-implantation dysfunction Download PDFInfo
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Abstract
The invention relates to a Chinese medicament for improving in vitro fertilization and embryo transfer (IVF-ET) post-implantation dysfunction. The Chinese medicament consists of the following medicinal materials in part by weight: 15 to 25 parts of rehmannia root, 8 to 12 parts of roasted ligustrum lucidum ait, 15 to 25 parts of roasted cuscuta chinensis, 8 to 12 parts of cibotium barometz, 8 to 12 parts of epimedium brevicornum maxim, 8 to 12 parts of donkey-hide gelatin, 8 to 12 parts of amomum villosum, 8 to 12 parts of roasted cornus officinalis, 8 to 12 parts of Chinese yam, 8 to 12 parts of eclipta prostrata, 8 to 12 parts of roasted eucommia ulmoides oliv, 8 to 12 parts of dipsacus asperoides, 15 to 25 parts of mistletoe, 8 to 12 parts of prepared tuber fleeceflower root, and 8 to 12 parts of liquorice. Experiments prove that the Chinese medicament can safely and effectively improve the IVF-ET post-implantation dysfunction.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of be used to the Chinese medicine that improves implantation barrier behind the IVF-ET.
Background technology
In vitro fertilization-embryo transfer (IVF-ET) technology refers to take out ovum in human female, in one stage of In vitro culture and sperm fertilization, will grow to the embryo transfer of regular period again and arrive in women's uterine cavity, makes its implantation develop into the process of fetus.It has obtained in the infertility field widely using, but present clinical pregnant success rate is still lower, and wherein the implantation barrier that causes of endometrium ability to accept difference is its one of the main reasons.To this, modern medicine does not still have effective solution.
The crude drug source that Chinese medicine of the present invention is related and application present situation are as follows:
Radix Rehmanniae: [source] this product is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..[function cures mainly] clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Be used for thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, consumption of YIN caused by febrile disease, the crimson tongue excessive thirst, constipation is hindered in Tianjin, fever due to yin deficiency, hectic fever due to YIN-deficiency burdock heat, interior-heat is quenched one's thirst.
Process Fructus Ligustri Lucidi: [source] Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plant Fructus Ligustri Lucidi Ligustrum lucidum Ait..Get the Fructus Ligustri Lucidi of choosing clean and mix thoroughly with yellow wine, put into jar or other container, obturage, put into the pot that adds water again, steam to wine and exhausted, taking-up is dried namely to get and is processed Fructus Ligustri Lucidi.[function cures mainly] nourishing the liver and kidney, black hair makes eye bright.Be used for the hepatic and renal YIN deficiency, dizzy ear toot, soreness of the waist and knees, the beard and hair drought is white, poor vision, interior-heat is quenched one's thirst, osteopyrexia and fever.
Semen Cuscutae (parched): [source] Semen Cuscutae is the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..Semen Cuscutae slow fire parching to brown namely gets Semen Cuscutae (parched).[function cures mainly] invigorating the liver and kidney, benefit essence, antiabortive.
Rhizoma Cibotii: [source] this product is Dicksoniaceae plant Rhizoma Cibotii Cibotium barometz(L.) dry rhizome of J.Sm..[function cures mainly] invigorating the liver and kidney, strong spinal column, wind-damp dispelling.Be used for soreness of the waist and knees, weakness of the lower extremities, rheumatic arthralgia.
Herba Epimedii: [source] this product is the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimedium sagittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai.[function cures mainly] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Colla Corii Asini: [source] this product is that the skin of equine species donkey Equus Asinus L. is through decocting, concentrate the solid gum of making.[function cures mainly] YIN nourishing of enriching blood is moisturized, hemostasis.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, the flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, chronic cough spitting of blood, haematemesis hematuria, the metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Fructus Amomi: [source] this product is the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T. L. Wu.[function cures mainly] removing dampness appetizing, warming spleen and stopping diarrha, it is antiabortive to regulate the flow of vital energy.Be used for turbid damp obstructing in middle-JIAO, the gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Fructus Corni Preparata: [source] Fructus Corni is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb. et Zucc..Get clean Fructus Corni, mix thoroughly with yellow wine, in putting jar or in other containers, obturage, be placed in the pot that adds water, steam to wine and exhausted, taking-up is dried, and namely gets Fructus Corni Preparata.[function cures mainly] liver and kidney tonifying, essence astringing and desertion stemming.Be used for vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.Interior-heat is quenched one's thirst.
Rhizoma Dioscoreae: [source] this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..[function cures mainly] spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.Be used for insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.
Herba Ecliptae: [source] this product is the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..[function cures mainly] nourishing the liver and kidney, cooling blood for hemostasis.Be used for odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, deficiency of YIN heat in blood, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Cortex Eucommiae (parched): [source] Cortex Eucommiae is the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..Cortex Eucommiae slow fire parching to brown namely gets Cortex Eucommiae (parched).[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Radix Dipsaci: [source] this product is the dry root of Dipsacaceae plant Radix Dipsaci Dipsacus asperoides C. Y. Cheng et T. M. Ai.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia.Be used for soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down more.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees more.
Herba Visci: [source] this product is the dry stem and branch with leaf of Loranthaceae plant Herba Visci Viscum coloratum (Komar.) Nakai.[function cures mainly] wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for rheumatic arthralgia, soreness of the waist and knees, frequent fetal movement.
Radix Polygoni Multiflori Preparata: [source] Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb..Radix Polygoni Multiflori Preparata is the process of preparing Chinese medicine processed goods of Radix Polygoni Multiflori.[function cures mainly] invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening.Be used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void; Hyperlipidemia.---
Radix Glycyrrhizae: [source] is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Summary of the invention
The present invention aims to provide a kind of be used to the Chinese medicine that improves implantation barrier behind the IVF-ET, by selecting suitable medical material and weight proportion thereof, with the purpose of the implantation barrier problem that reaches safe and effective solution IV F-ET patient.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of be used to the Chinese medicine that improves implantation barrier behind the IVF-ET, it is characterized in that: it is made up of following medicinal materials in part by weight: Radix Rehmanniae 15-25 part, process Fructus Ligustri Lucidi 8-12 part, Semen Cuscutae (parched) 15-25 part, Rhizoma Cibotii 8-12 part, Herba Epimedii 8-12 part, Colla Corii Asini 8-12 part, Fructus Amomi 8-12 part, Fructus Corni Preparata 8-12 part, Rhizoma Dioscoreae 8-12 part, Herba Ecliptae 8-12 part, Cortex Eucommiae (parched) 8-12 part, Radix Dipsaci 8-12 Fen, Herba Visci 15-25 part, Radix Polygoni Multiflori Preparata 8-12 part, Radix Glycyrrhizae 8-12 part.Wherein preferred: as 20 parts of Radix Rehmanniae, to process 10 parts of Fructus Ligustri Lucidi, 20 parts of Semen Cuscutae (parched), 10 parts of Rhizoma Cibotii, 10 parts of Herba Epimedii, 10 parts in Colla Corii Asini, 10 parts of Fructus Amomis, 10 parts of Fructus Corni Preparata, 10 parts of Rhizoma Dioscoreaes, 10 parts of Herba Ecliptaes, 10 parts of Cortex Eucommiae (parched), Radix Dipsaci 10 20 parts of Fen, Herba Visci, 10 parts of Radix Polygoni Multiflori Preparatas, 10 parts in Radix Glycyrrhizae.
The concrete using method of the present invention: the patient needs behind embryo transfer 1-7 days, take every day: use " Radix Rehmanniae 15-25 gram; process Fructus Ligustri Lucidi 8-12 gram; Semen Cuscutae (parched) 15-25 gram; Rhizoma Cibotii 8-12 gram; Herba Epimedii 8-12 gram; Colla Corii Asini 8-12 gram, Fructus Amomi 8-12 gram, Fructus Corni Preparata 8-12 gram, Rhizoma Dioscoreae 8-12 gram, Herba Ecliptae 8-12 gram, Cortex Eucommiae (parched) 8-12 gram, Radix Dipsaci 8-12 gram Herba Visci 15-25 gram, Radix Polygoni Multiflori Preparata 8-12 gram, Radix Glycyrrhizae 8-12 gram, wherein preferred: Radix Rehmanniae 20 grams, process Fructus Ligustri Lucidi 10 grams, Semen Cuscutae (parched) 20 grams, Rhizoma Cibotii 10 grams, Herba Epimedii 10 grams, Colla Corii Asini 10 grams, Fructus Amomi 10 grams, Fructus Corni Preparata 10 grams, Rhizoma Dioscoreae 10 grams, Herba Ecliptae 10 grams, Cortex Eucommiae (parched) 10 grams, Radix Dipsaci 10 gram Herba Visci 20 grams, Radix Polygoni Multiflori Preparata 10 grams, Radix Glycyrrhizae 10 gram " patent medicine that makes, can be divided into 1-3 clothes time.
Below in conjunction with theory of Chinese medical science the beneficial effect that we are bright is described:
The inventor finds in practice process, selects the patient of IV F-ET to be different from common gravid woman, their most plain body deficiency of kidney-QI, deficiency of qi and blood, and long-term infertile stress, cause again stagnation of liver-QI do not understand, qi-blood disharmony.Kidney is appointed originally for dashing, and deficiency of kidney-QI causes the debility of CHONG and REN meridians; Do not carry tire a little less than the gas, not fetus nourishing of anemia, deficiency of qi and blood then nausea is difficult for solid supporting; Stagnation of liver-QI is not understood, malaise if add, and is unfavorable for more that then feotus vitality is strong solid.
Spleen is source of generating QI and blood, so the inventor thinks that kidney and spleen invigorating is taken good care of QI and blood, the resolving depression of calming the nerves is when becoming the key that solves IV F-ET patient implantation barrier.
Chinese medicine of the present invention uses processs Fructus Ligustri Lucidi, Semen Cuscutae (parched), Rhizoma Cibotii, Herba Epimedii, Fructus Corni Preparata, Herba Ecliptae, Cortex Eucommiae (parched), Radix Dipsaci, liver and kidney tonifying; Use Fructus Amomi, Rhizoma Dioscoreae, invigorating the spleen and replenishing QI; Use Radix Rehmanniae, Colla Corii Asini, nourishing YIN and benefiting blood; Use Radix Glycyrrhizae again, coordinating the actions of various ingredients in a prescription.Thereby reach kidney and spleen invigorating, take good care of QI and blood, the purpose of the resolving depression of calming the nerves, remove IV F-ET patient's implantation barrier problem.
Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:
1, physical data
Between in June, 2008-2011 year JIUYUE, the inventor collects the women that 85 examples are carried out IV F-ET altogether, age 27-43 year.The reference patient wish is divided into: test group 40 examples, matched group 25 examples, blank group 20 examples.Three groups of patient age, cardinal symptom etc. more all do not have significant difference, have comparability.
2, Therapeutic Method
Test group: take the decoct that optimization formula of the present invention makes, every day 1 time, took in 1-7 days behind the embryo transfer;
Matched group: take Progesterone soft gelatin capsule (Aisheng Pharmaceutical Co., Ltd., Zhejiang), take according to its description usage and dosage, took in 1-20 days behind the embryo transfer;
Blank group: do not take any medicine.
3, computational methods
Effective percentage=(blank group abortion ratio-treatment group abortion ratio or matched group abortion ratio)/blank group abortion ratio
4, therapeutic outcome
Treatment statistical result sees Table 1.
Table 1 liang group curative effect relatively
| Group | n | Miscarriage | Abortion ratio | Effective percentage |
| Test group | 40 | 6 | 15% | 62.5% |
| Matched group | 25 | 5 | 20% | 50% |
| Blank group | 20 | 12 | 40% | / |
As seen, the medicine that makes of the preferred embodiment for the present invention can be safe and effective be used to the implantation barrier problem of improving behind the IVF-ET.
According to above-mentioned clinical experiment data, in conjunction with analysis and the known in this field general knowledge of inventor to the Chinese medicine mechanism of action of the present invention, those skilled in the art know by inference easily, use the medical material among the present invention, near value optimum weight part, at least " Radix Rehmanniae 15-25 part; process Fructus Ligustri Lucidi 8-12 part; Semen Cuscutae (parched) 15-25 part; Rhizoma Cibotii 8-12 part; Herba Epimedii 8-12 part; Colla Corii Asini 8-12 part, Fructus Amomi 8-12 part, Fructus Corni Preparata 8-12 part, Rhizoma Dioscoreae 8-12 part, Herba Ecliptae 8-12 part, Cortex Eucommiae (parched) 8-12 part, Radix Dipsaci 8-12 part Herba Visci 15-25 part, Radix Polygoni Multiflori Preparata 8-12 part, Radix Glycyrrhizae 8-12 part " scope in, can obtain the medicine similar techniques effect that makes with the preferred embodiment for the present invention.
The specific embodiment
In order to understand better and to implement the present invention, further specify the present invention below in conjunction with specific embodiment.
Specific embodiment 1
A kind of be used to the Chinese medicine that improves implantation barrier behind the IVF-ET, made by following medical material: Radix Rehmanniae 20 grams, process Fructus Ligustri Lucidi 10 grams, Semen Cuscutae (parched) 20 grams, Rhizoma Cibotii 10 grams, Herba Epimedii 10 grams, Colla Corii Asini 10 grams, Fructus Amomi 10 grams, Fructus Corni Preparata 10 grams, Rhizoma Dioscoreae 10 grams, Herba Ecliptae 10 grams, Cortex Eucommiae (parched) 10 grams, Radix Dipsaci 10 Ke, Herba Visci 20 grams, Radix Polygoni Multiflori Preparata 10 grams, Radix Glycyrrhizae 10 grams.
Described preparation method of Chinese medicine is: take by weighing above-mentioned medical material, according to common process extracting in water twice, merging filtrate concentrates, packing.Namely get the decoct that meets one day consumption of normal adult.
Be used for improving implantation barrier behind the IVF-ET, took in 1-7 days behind the embryo transfer.Oral, every day 1 time.
Specific embodiment 2
A kind of be used to the Chinese medicine that improves implantation barrier behind the IVF-ET, made by following medical material: Radix Rehmanniae 15 grams, process Fructus Ligustri Lucidi 8 grams, Semen Cuscutae (parched) 15 grams, Rhizoma Cibotii 8 grams, Herba Epimedii 8 grams, Colla Corii Asini 8 grams, Fructus Amomi 8 grams, Fructus Corni Preparata 8 grams, Rhizoma Dioscoreae 8 grams, Herba Ecliptae 8 grams, Cortex Eucommiae (parched) 8 grams, Radix Dipsaci 8 Ke, Herba Visci 15 grams, Radix Polygoni Multiflori Preparata 8 grams, Radix Glycyrrhizae 8 grams.
Described preparation method of Chinese medicine is: take by weighing above-mentioned medical material, according to common process extracting in water twice, merging filtrate, concentrate, drying gets extract, add an amount of polyethylene glycol 6000, be prepared into drop pill according to conventional pharmaceutical technology, namely get the drop pill that meets one day consumption of normal adult.
Be used for improving implantation barrier behind the IVF-ET, took in 1-7 days behind the embryo transfer.Oral, divide sooner or later every day and take for 2 times.
Specific embodiment 3
A kind of be used to the Chinese medicine that improves implantation barrier behind the IVF-ET, made by following medical material: Radix Rehmanniae 25 grams, process Fructus Ligustri Lucidi 12 grams, Semen Cuscutae (parched) 25 grams, Rhizoma Cibotii 12 grams, Herba Epimedii 12 grams, Colla Corii Asini 12 grams, Fructus Amomi 12 grams, Fructus Corni Preparata 12 grams, Rhizoma Dioscoreae 12 grams, Herba Ecliptae 12 grams, Cortex Eucommiae (parched) 12 grams, Radix Dipsaci 12 Ke, Herba Visci 25 grams, Radix Polygoni Multiflori Preparata 12 grams, Radix Glycyrrhizae 12 grams.
Described preparation method of Chinese medicine is: take by weighing above-mentioned medical material, according to common process extracting in water twice, merging filtrate concentrates, and drying gets extract, incapsulates shell, namely gets the capsule that meets one day consumption of normal adult.
Be used for improving implantation barrier behind the IVF-ET, took in 1-7 days behind the embryo transfer.Oral, divide every day take 3 times morning, noon and afternoon.
Claims (2)
1. Chinese medicine that is used for improving implantation barrier behind the IVF-ET, it is characterized in that: it is made up of following medicinal materials in part by weight: Radix Rehmanniae 15-25 part, process Fructus Ligustri Lucidi 8-12 part, Semen Cuscutae (parched) 15-25 part, Rhizoma Cibotii 8-12 part, Herba Epimedii 8-12 part, Colla Corii Asini 8-12 part, Fructus Amomi 8-12 part, Fructus Corni Preparata 8-12 part, Rhizoma Dioscoreae 8-12 part, Herba Ecliptae 8-12 part, Cortex Eucommiae (parched) 8-12 part, Radix Dipsaci 8-12 part, Herba Visci 15-25 part, Radix Polygoni Multiflori Preparata 8-12 part, Radix Glycyrrhizae 8-12 part.
2. described be used to the Chinese medicine that improves implantation barrier behind the IVF-ET according to claim 1, it is characterized in that: it is made up of following medicinal materials in part by weight: 20 parts of Radix Rehmanniae, process 10 parts of Fructus Ligustri Lucidi, 20 parts of Semen Cuscutae (parched), 10 parts of Rhizoma Cibotii, 10 parts of Herba Epimedii, 10 parts in Colla Corii Asini, 10 parts of Fructus Amomis, 10 parts of Fructus Corni Preparata, 10 parts of Rhizoma Dioscoreaes, 10 parts of Herba Ecliptaes, 10 parts of Cortex Eucommiae (parched), Radix Dipsaci 10 20 parts of Fen, Herba Visci, 10 parts of Radix Polygoni Multiflori Preparatas, 10 parts in Radix Glycyrrhizae.
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| CN105169081A (en) * | 2015-10-25 | 2015-12-23 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine for treating IVF (in vitro fertilization) implantation failure with syndrome of blood-heat stasis obstruction |
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| CN1315197A (en) * | 2000-03-28 | 2001-10-03 | 张瑞友 | Medicine for female acyesis |
| CN101279073A (en) * | 2008-04-10 | 2008-10-08 | 北京中泰天和科技有限公司 | Chinese medicinal composition for curing habitual abortion and method of preparing the same |
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| CN1315197A (en) * | 2000-03-28 | 2001-10-03 | 张瑞友 | Medicine for female acyesis |
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