CN102526217B - Formula of health-care medicine with functions of strengthening immunity and promoting sleep - Google Patents
Formula of health-care medicine with functions of strengthening immunity and promoting sleep Download PDFInfo
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Abstract
The invention relates to a formula of a health-care medicine with functions of strengthening immunity and promoting sleep. The health-care medicine capsules are prepared from the raw materials in part by weight: 6 to 15 parts of broccoli extract, 6 to 9 parts of melatonin, 4.5 to 10 parts of lotus plumule extract, 1.5 to 5 parts of polygala tenuifolia, 4.5 to 6 parts of tuber fleeceflower stem, 4.5 to 12 parts of Chinese arborvitae seed and 3 to 10 parts of microcrystalline cellulose. The health-care medicine can improve the symptoms of insomnia and dreamful sleep of people, the health level of people, and the life quality of people who have low immunity, and does not have side effect or adverse reaction; and the product is safe, stable, and controllable in quality because a modern preparation technology and an advanced quality control method are adopted.
Description
Technical field
The present invention relates to a kind of health medicine, relate in particular to a kind of enhancing immunity, hypnotic functional health medicine.
Background technology
Along with the development in epoch and the quickening of rhythm of life, the development of society, the fierceness day by day of competition, the life stress that people face is also increasing.The insomnia problem that professional population often has each colony that begun to extend.Insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Claim again DIMS (DIMS), Chinese medicine is called again: be insomnia, insomnia, must not crouch, the unable to close the eyes, to take often to obtain a kind of disease that ortho sleep is feature, for a variety of causes causes that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., the common reason of insomnia that causes mainly contains environment reason, individual factors, body reason, Nervous and Mental Factors, emotional factor etc.According to Traditional Chinese medical theory, the reason of insomnia is mainly internal organs disorder, especially the warming YANG function of the heart and the YIN nourishing function of kidney can not coordination, deficiency of qi and blood, imbalance of YIN and YANG etc.Not having sleep just there is no health is that medical research personnel are according to the neodoxy in recent years latest result of sleep study being proposed.The quality of sleep quality, relates to normally carrying out of various functions activity while waking up.Relevant research shows, sleep, except can allaying tiredness, produces outside new vitality human body, also with the ability close relation that improves immunity, resist the disease.Sleep disorder has a strong impact on quality of life.With the quickening pace of modern life and the change of life style, the sickness rate of sleep disorder increases gradually, and has become a major issue of the current medical circle of puzzlement.
Sleep disorder increases along with the increase at age, and the sickness rate in old people is especially high.World Health Organization (WHO) proposes, and the over-65s person of developed country is old people, and 60 years old above person of developing country is old people.The above aging population of China 60 years old are with annual 3.2% speed increment.Foreign study discovery, in old people, the prevalence rate of sleep disorder is 30%-40%.International spiritual and neurological foundation investigation demonstration in 2002, has 45% to have sleep disorder in population of China, its middle-aged and elderly people accounts for 56.7%.In various sleep disorder, insomnia is modal one type, and it refers to starting of sleep and maintain generation obstacle, is a kind of subjective experience that sleep quality or quantity do not reach normal demand.Long-term insomnia, can serious harm old people physically and mentally healthy, be also accident and the dead high risk factor occurring simultaneously.So how safely and reasonably to use the medicine of sleeping peacefully, improve the physically and mentally healthy level of old people, become the study hotspot of life sciences.
China is engaged in research and the production of natural drug, there is advantageous condition, the rarity of Traditional Chinese Medicine, it has the clinical experience of several thousand, from current pharmaceutical research trend, from natural product, find new drug or find that guide is combined to thing and it is carried out to the important content that structural modification is drug development, add growth in the living standard and also make people have higher pursuit to the quality of life.Thereby more pay attention to health, pay attention to sleeper effect.Under this background, this formula uses high-tech means and the free of contamination pure natural animals and plants of take are aided with the enhancing immunity that other functional components are raw material, the health product of hypnotic function arise at the historic moment, and develop rapidly.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of enhancing immunity, hypnotic functional health medicine; Can assist people to build up resistance, hypnotic quality, improves quality of life of insomniac.
Enhancing immunity of the present invention, hypnotic functional health medicine, made by the raw material of following parts by weight: Caulis et Folium Brassicae capitatae 6-15, melatonin 6-9, Plumula Nelumbinis extract 4.5-10, Radix Polygalae 1.5-5, Caulis Polygoni Multiflori 4.5-6, Semen Platycladi 4.5-12, microcrystalline Cellulose 3-10.
The preparation method of enhancing immunity of the present invention, hypnotic functional health medicine, comprises the following steps:
1) first Radix Polygalae 1.5-5 part, Caulis Polygoni Multiflori 4.5-6 part, Semen Platycladi 4.5-12 part are pulverized respectively, cross 60-80 mesh sieve;
2) powder step 1 of learning from else's experience) obtaining mixes with the raw material of following parts by weight: Caulis et Folium Brassicae capitatae 6-15, melatonin 6-9, Plumula Nelumbinis extract 4.5-10, microcrystalline Cellulose 3-10; Incorporation time 45 minutes;
3) through step 2) after mix homogeneously, then carry out capsule-filling, filling process is controlled capsule filling weight in strict accordance with inner quality standard, then screen, polishing, inner packing, then carry out outer package, finally by touchstone check warehouse-in.
Compared with prior art beneficial effect of the present invention is: health medicine capsule of the present invention can improve people's insomnia and dreamful sleep symptom, improve people's health level, improve immunocompromised person's quality of life, have no side effect and untoward reaction, and use modern preparation technique, advanced method of quality control, makes product accomplish safety, stable, quality controllable.
Accompanying drawing explanation
Fig. 1 be in enhancing immunity described in the embodiment of the present invention, hypnotic functional health medicine melatonin to the circadian influence curve figure of mice sleep.
The specific embodiment
Below in conjunction with drawings and Examples, the specific embodiment of the present invention is described in further detail.Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
Enhancing immunity, a hypnotic functional health medicine, by following weight (gram) raw material make: Caulis et Folium Brassicae capitatae 15, melatonin 8, Plumula Nelumbinis extract 4.5, Radix Polygalae 1.5, Caulis Polygoni Multiflori 5, Semen Platycladi 4.5, microcrystalline Cellulose 6.
The preparation method of enhancing immunity of the present invention, hypnotic functional health medicine, comprises the following steps:
1) first 4.5 grams of 1.5 grams of Radix Polygalaes, 5 grams of Caulis Polygoni Multiflori, Semen Platycladi are pulverized respectively, crossed 60-80 mesh sieve;
2) powder step 1 of learning from else's experience) obtaining with following weight (gram) raw material mix: Caulis et Folium Brassicae capitatae 15, melatonin 8, Plumula Nelumbinis extract 4.5, microcrystalline Cellulose 6; Incorporation time 45 minutes;
3) through step 2) after mix homogeneously, then carry out capsule-filling, filling process is controlled capsule filling weight in strict accordance with inner quality standard, then screen, polishing, inner packing, then carry out outer package, finally by touchstone check warehouse-in.
Embodiment 2
Enhancing immunity, a hypnotic functional health medicine, by following weight (gram) raw material make: Caulis et Folium Brassicae capitatae 12, melatonin 9, Plumula Nelumbinis extract 7, Radix Polygalae 4, Caulis Polygoni Multiflori 6, Semen Platycladi 8, microcrystalline Cellulose 8.
The preparation method of described enhancing immunity, hypnotic functional health medicine is with embodiment 1.
Embodiment 3
Enhancing immunity, a hypnotic functional health medicine, by following weight (gram) raw material make: Caulis et Folium Brassicae capitatae 7, melatonin 9, Plumula Nelumbinis extract 10, Radix Polygalae 5, Caulis Polygoni Multiflori 6, Semen Platycladi 11, microcrystalline Cellulose 10.
The preparation method of described enhancing immunity, hypnotic functional health medicine is with embodiment 1.
Enhancing immunity of the present invention, hypnotic functional health medicine can improve insomniac's symptom, improve people's health level, improve insomniac's quality of life, have no side effect and untoward reaction, and use modern preparation technique, advanced method of quality control, makes product accomplish safety, stable, quality controllable.
Each component in enhancing immunity of the present invention, hypnotic functional health medicine has following characteristics:
1) Caulis et Folium Brassicae capitatae extracts from Caulis et Folium Brassicae capitatae, and Caulis et Folium Brassicae capitatae has another name called broccoli, blue and white Lay, sprouting broccoli etc., belongs to the mutation that Cruciferae Caulis et Folium Brassicae campestris belongs to brassica specie, is one, biennial herb plant, originates in Italy.Have and experimental results show that Caulis et Folium Brassicae capitatae contains abundant cancer-resisting substance and can lower the formation to mouse breast tumor, stop the activity of carcinogen.Scientist finds that the anti-cancer material in the brassicaceous vegetables such as Caulis et Folium Brassicae capitatae is enzymatic hydrolysate or the derivant of thioglycoside, wherein isothiocyanate class most importantly.Glucorphanin is a kind of of thioglycoside, is extensively present in Caulis et Folium Brassicae capitatae, and glucorphanin produces isothiocyanate through myrosinase enzymolysis or acid hydrolysis: sulforaphen.Sulforaphen is the strongest anti-cancer active matter of finding in vegetable up to now, because it finds to gain the name in Radix Raphani.The foreign son professor of Japan nutritionist good fortune man waits and passes through verification experimental verification: in the crucifers such as Brassica oleracea L.var.capitata and Caulis et Folium Brassicae capitatae, contained isothiocyanic acid ester derivant sulforaphen has treatment cancer and the effectiveness of killing leukocyte, and this is to confirm that for the first time it has the effect of killing leukaemia.Show according to the study in the fresh Caulis et Folium Brassicae capitatae of freshly harvested that glucorphanin (3-methylsulfinyl acrylic thioglycoside) and Glucoraphanin account for 78% of total glucosinolate content.Under common content, glucorphanin and its catabolite have important benefits to health, although glucorphanin is not direct beneficial organism active substance, its hydrolyzate sulforaphen has the defencive function that strengthens human body.
The relation of sulforaphen and immunocompetence is mainly: existingly studies have shown that sulforaphen has the function that improves immunity abroad.Experiment shows: within continuous 9 days, give BALB/c (4-6 age in week) mouse every day (every of 500ug/) feed sulforaphen, within the 9th day, total leukocyte counting is strengthened one times of amount, the quantity of medullary cell and esterase A positive cell has also increased by one times, hemolysis plaque number obviously raises, synthetic antibody number obviously increases, and sulforaphen has also improved the activate the phagocytic capacity of peritoneal macrophage.In addition Radix Raphani sulfur greatly reduces the higher leveled TNF-a being produced by LPS (endotoxin) stimulating expression of macrophage.These results show, sulforaphen improves immunity and auxiliary obesity is improved microenvironment successful in body.In addition through zoopery, show: sulforaphen is remarkable in the effect of anti-tumor aspect.Sulforaphen after taking food to mouse high dose (μ mol/kg every days 100) continuously for 4-5 days, and in mouse liver, lung, mammary gland, pancreas, stomach, small intestinal and colon, the activity of II phase detoxication enzyme is all improved.Munday etc. have compared the ability that six kinds of ITCs induce the Phase II detoxication enzymes such as QR (quinone reductase), GST (glutathione transferase) in mouse Different Organs.Test dose is μ mol/kg every days 40, and feeding is 5 days continuously.Result shows that all ITCs have shown the activity of inducing QR and GST in duodenum, stomach, bladder, and wherein sulforaphen induces the activity of GST the strongest in duodenum and bladder, and in all organs, the effect with bladder is the most remarkable again.Jackson etc. study discovery, F311 breast cancer cell to BALB/c mouse when sulforaphen reaches 15nmol/L concentration has inhibitory action, within continuous 13 days, give BALB/c mouse injection 15nmol/d, the sulforaphen of concentration, the F311 breast cancer cell of mouse reduces about 60%.
Above experimental data proof sulforaphen tool increase significantly immunity and antitumor efficacy, but because sulforaphen itself is very unstable, this product adopts its prerequisite glucorphanin as main component, through zoopery proof, take glucorphanin, through enzymolysis, become sulforaphen in animal body, can reach and directly take the effect that sulforaphen is identical, and product is more stable.
Through acute toxicology, nursing experiment in 30 days, all there is not any side effect and untoward reaction in this product.This product adopts ethanol and water to extract from vegetable Caulis et Folium Brassicae capitatae in addition, there is no other pollution.The dosage adopting, in usual Caulis et Folium Brassicae capitatae vegetable edible range.Show that this prescription is feasible, there is good using value.
2) melatonin is a kind of endogenous material, by the adjusting of hormonal system, works, and has in vivo the metabolic pathway of oneself.Melatonin in blood has 70%-75% to become after 6-hydroxyl melatonin sulphate form at liver metabolism, through urine (80%) and excrement (20%), excretes; Another 5%-7% changes into 6-hydroxyl melatonin Portugal candy thuja acid form, can not cause metabolite to accumulate in vivo; And its biological half-life is short, at oral 7-8h, be down to normal person's physiological level, so its toxicity is minimum.Directly the melatonin of impact sleep, mainly regulates sleep phases under normal circumstances, if take melatonin outside under wakefulness state, can play syngignoscism.Melatonin is the optical signal hormone of pinus secretion, regulate animal circadian rhythm and season the rhythm and pace of moving things and body " Sleep-Wake " rhythm and pace of moving things aspect play an important role.Under normal condition, human body in the daytime melatonin levels is lower.In the daytime applying melatonin can make body temperature reduce 0.3-0.4 ℃.Giving bright light night stimulates the secretion that can suppress melatonin, makes fervescence, causes nighttime sleep amount to reduce simultaneously.If the outer material that takes relevant melatonin class, all has quick syngignoscism to animal and human.
Because sunlight and melatonin have close relationship.At the pinus position of brain, be subject to, after the stimulation of light, just suppressing the secretion of melatonin.Daytime, the release of melatonin was suppressed as taken a solar bath well, can promote the release of melatonin at night, thereby obtain fragrant and sweet sleep.
Melatonin is with age growth, and secretion reduces, and may be therefore to cause one of reason that old people's sleep quality declines, sleep disorder increases.Suitably utilize melatonin, can improve old people and often face that the time difference changes or day alternates with night staff's sleep quality.And nearest research discovery, in fact the melatonin that is always used for the treatment of insomnia has significant immunoregulation effect.
(1) the impact test of melatonin on pentobarbital sodium sub-threshold lull dosage: mice is divided into 4 groups at random, and pentobarbital sodium sub-threshold lull dosage is 25mg/kg.From table 1, po melatonin 120mg/kg can obviously increase the mice number of elements of falling asleep, and pentobarbital sodium sub-threshold lull dosage is had to synergism.
The affect n=10 of table 1 melatonin on pentobarbital sodium sub-threshold lull dosage
Note: with matched group comparison, * P < 0.01; * P < 0.05
(2) melatonin extends the pentobarbital sodium test length of one's sleep: mice is divided into 4 groups at random.Pentobarbital sodium dosage is 40mg/kg.From table 2, po melatonin 30 and 16mg/kg all can significant prolongation pentobarbital sodium the length of one's sleep.
Table 2 melatonin on the pentobarbital sodium impact of the length of one's sleep (
n=10 ∽ 12)
Note: with matched group comparison, * P < 0.01; * P < 0.05
(3) melatonin is on the circadian impact of pentobarbital sodium induced hypnotic: as seen from Figure 1, matched group pentobarbital sodium presents circadian changes the length of one's sleep, and when peak value appears at 12:00, valley is when 20:00.After use melatonin, can extend the length of one's sleep of pentobarbital sodium, but the degree extending depends on administration time, visible rhythm and pace of moving things position shifts to an earlier date mutually, and peak value appears at 08:00, and valley appears at 16:00.The effect that melatonin extends pentobarbital sodium length of one's sleep because of division of day and night round the clock different.
(4) the impact test of melatonin on mouse hypothalamus, cerebral cortex, brain stem GABA content: mice is divided into 3 groups at random.From table 3, the melatonin 15mg/kg content of GABA in hypothalamus that can obviously raise, but the rising of other brain district GABA content is had no significant effect.
Table 3 melatonin on the impact of Different brain region alpha-aminobutyric acid content (
n=6 ∽ 8)
Note: with matched group comparison, * P < 0.05
(5) the impact test of melatonin on mouse hypothalamus, cerebral cortex, brain stem Glu content: mice is divided into 3 groups at random.From table 4, melatonin 15 or 5mg/kg have no significant effect mice Ge Nao district GLU content.
Table 4 melatonin on the impact of Different brain region content of glutamic acid (
n=6 ∽ 8)
Endogenous melatonin has low synthetic and Secretion Rhyme in high daytime at unique night, this physiological rhythm and pace of moving things is controlled by the photoperiod, because melatonin secretion at midnight is maximum, be also called " dark hormone ", it is regulating circadian rhythm to play an important role aspect sleep awakening.Some scholar thinks, melatonin Main Function is to set up the time that sleep occurs, and corrects the disorderly sleep awakening rhythm and pace of moving things.The method that this experiment adopt to extend pentobarbital sodium length of one's sleep is observed the impact of melatonin on sleep, and each experiment all adopts special messenger to observe.Found that single gives melatonin and can improve the number of elements that pentobarbital sodium sub-threshold lull dosage mice falls asleep, extend pentobarbital sodium length of one's sleep, visible single gives melatonin and has direct syngignoscism.
In sum, melatonin is for building up one's resistance to disease, and hypnotic quality has goodish effect.
3) Plumula Nelumbinis extract extracts from Semen Nelumbinis, and Semen Nelumbinis are nymphaeaceae plant, have another name called Hibisci Mutabilis, is to have the perennial water plant of expanding rhizome.Semen Nelumbinis are felt concerned about dry spire and the radicle of the mature seed of lotus.< < Compendium of Materia Medica > > records its nature and flavor bitter cold, GUIXIN lung kidney 3 warps, and tool clears away heart-fire and purges heat, the effect of controlling nocturnal emission with astringent drugs hemostasis.The traditional Chinese medical science is for the treatment of the cards such as thermal man's pericardium, disarmony between the heart and kidney, insomnia seminal emission, heat in blood haematemesis.Modern study shows: Plumula Nelumbinis contains the chemical compositions such as alkaloid, flavone, sitosterol, volatile oil and trace element; There is blood pressure lowering, arrhythmia, antiplatelet aggregation, anti peroxidation of lipid and remove free radical, the pharmacological action such as anticancer.What in its numerous chemical compositions, have obvious biological activity and physiological function is flavone and this two large class material of alkaloid.Wherein flavones ingredient is mainly rutin and Quercetin.Alkaloids composition is mainly nuciferine, nuciferine, 0 one demethyl lotus alkali.Plumula Nelumbinis begins to be loaded in < < feeding habits book on Chinese herbal medicine > >, has another name called the lotus heart of a lotus seed.For the tender plumule of the green grass or young crops in Semen Nelumbinis.Its nature and flavor bitter cold, enters the heart, lung, kidney three warps, has the effect of clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding.< < Compendium of Materia Medica > >, < < Japan hanako materia medica > >, the large bright will > > that unifies of < <, < < book on Chinese herbal medicine is new > > again, the bun of < < medical center is wanted all to include in the ancient books and records such as > >.With Semen Nelumbinis, Rhizoma Coptidis, the Radix Rehmanniae, Semen Ziziphi Spinosae, Poria cum Radix Pini, Radix Polygalae cooperation, form.Serve on 1 month, nocturnal emission just can reduce, and this side comes from < < Dong-eui-bo-gam > >.Its clearing away heart-fire of clinical report, suppressing the hyperactive liver fire, rush down stomach-fire, fall lung-fire, can treat the vexed insomnia of old people, adolescence's hyperactivity of heart-fire etc.
4) Radix Polygalae is conventional Chinese medicine, begins to be loaded in < < Sheng Nong's herbal classic > >, is listed in top gradely, is the key medicine of supporting life.There is intelligent promoting and the mind tranquilizing, eliminating phlegm for diminishing swelling effect, be usually used in clinically treating the diseases such as insomnia and dreamful sleep, forgetful palpitation with fear, staring spells, expectoration that disarmony between the heart and kidney causes are not well, sore swollen toxin, breast swell and pain.In the just > > of < < book on Chinese herbal medicine, says " Radix Polygalae, the wholwe-hearted kidney of merit, thus can relieving palpitation spasmolytic, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, by force will power-assisted.
(1) the impact test of Radix Polygalae on mice autonomic activities: compare with blank group, after 1, No. 2 mice administrations of Radix Polygalae group, autonomic activities number of times obviously reduces, and after 3, No. 4 mice administrations of low dosage Radix Polygalae group, autonomic activities number of times also obviously reduces.Under different condition, Radix Polygalae all can reduce mice autonomic activities number of times and obviously have sedation.In Table 5.
Table 5 Radix Polygalae on the impact of mice autonomic activities (
n=10)
Note: with matched group comparison, * P < 0.05, * * P < 0.01
(2) on the fall asleep impact test of number of elements of mice: compare with blank group, No. 3 high dose group of Radix Polygalae and No. 6 low dose group mices of Radix Polygalae number of elements of falling asleep obviously increases (P < 0.010), and prompting Radix Polygalae has for 3, No. 6 without barbital increases the fall asleep effect of number of elements of mice by sodium.Table 6.
Table 6 various dose is on the fall asleep impact of number of elements of mice
Note: with matched group comparison, * * P < 0.01
5) rattan of Caulis Polygoni Multiflori different name Caulis Polygoni Multiflori ，Wei trailing plants section Plant-Polygonum.There is tranquilizing by nourishing the heart, the effect of dredging collateral wind dispelling.This experimentation is intended, by the tracing and analyzing of rat brain electrograph (EEG), determining the impact of Caulis Polygoni Multiflori on the Sleep in Rats cycle, for its tranquilizing by nourishing the heart effect provides experimental basis.
(2) when Caulis Polygoni Multiflori is on normal Sleep in Rats to impact test: as known from Table 7, Caulis Polygoni Multiflori can obviously reduce the awakening time (W) (P < 0.01) of rat, extend TST (P < 0.01), on sleep phases, Caulis Polygoni Multiflori main manifestations, for extending SWS2 (P < 0.05) and SWS1 (P < 0.01), can increase SWS.
The impact of table 7 Caulis Polygoni Multiflori phase during on normal Sleep in Rats
Note: with matched group comparison, * P < 0.01
Result of the test shows: Caulis Polygoni Multiflori decocting liquid can extend freely movable rat total length of one's sleep (P < 0.01), and on sleep phases, main manifestations is for extending SWS1, and SWS2, on not significantly impact of REMS.Show that accordingly Caulis Polygoni Multiflori decocting liquid can promote body development, accelerate tired recovery, extend sleep.
(3) the promotion test of Caulis Polygoni Multiflori normal rat sleep
Table 8 barbital sodium sub-threshold dose hypnosis experimental result
Note: with matched group comparison, * P < 0.05, * * P < 0.01
From table 8: low, high dose glycoside dosage Caulis Polygoni Multiflori flavone in low is compared the mice rate of falling asleep and is significant difference (comparing P < 0.05 with Normal group) and shows that it has facilitation to increasing rate of falling asleep of injection sub-threshold dose barbital sodium mice with matched group; Rate that glycoside is low, the animal of high dose falls asleep is apparently higher than blank water, yet between dosage group, but there is no dependency relation, that in zoopery, the difference of live body causes, the animal of the basic, normal, high dosage of while Caulis Polygoni Multiflori anthraquinone, fall asleep animal number of elements all higher than blank water, and in rising trend with the rising of the dosage number of animals of falling asleep, each dosage group and blank water difference not significantly (through the inspection of the side of card) if suitably improve dosage, can significantly increase the animal rate of falling asleep.
From following table 9, high dose glycoside is compared mouse sleep time and is significant difference (comparing P < 0.05 with Normal group) with matched group, show that it has facilitation to extending the length of one's sleep of injection pentobarbital sodium mice.
Table 9 extends the pentobarbital sodium experimental result length of one's sleep
In this research, glycoside demonstrates the effect of certain improvement sleep, in barbital sodium sub-threshold dose hypnosis experiment, compare with matched group, the mice rate of falling asleep is significant difference (comparing P < 0.05 with Normal group) in barbital sodium Sleep latency experiment, and glycoside high dose is compared mouse sleep time and is significant difference (comparing P < 0.05 with Normal group) and illustrates that it has facilitation for Sleeping Time Prolong Ed with matched group.
6) Semen Platycladi nature and flavor are sweet, flat, GUIXIN, liver, spleen channel.Function the heart nourishing and intellengence improving, calm the nerves, moisturize, loosening bowel to relieve constipation, cure mainly neurasthenia, the symptoms such as insomnia, fidgets due to deficiency.
(1) direct sleep experiments result: by national standard method, three kinds of active component in Semen Platycladi are carried out to direct sleep experiments, the results are shown in Table 10.
Table 10 number of animals (n=12) of directly sleeping in sleep experiments
From table 10, the number of animals of directly sleeping in 11 treated animals in sleep experiments is 0, be in Semen Platycladi each composition extremely matched group to mice all without direct syngignoscism, meet the requirement that improves sleep health food in the check of < < health food and assessment technique enforcement of regulations handbook > >, can carry out other three experiments.
(2) barbital sodium sub-threshold dose hypnosis experimental result: by national standard method, three kinds of active component in Semen Platycladi are carried out to barbital sodium sub-threshold dose hypnosis experiment, study its impact on mice sleep rate, the results are shown in Table 11.
The impact of table 11 Semen Platycladi composition on mice sleep rate
Note: with blank group comparison separately, ※ P < 0.05.
From table 11, high dose Semen Platycladi fatty oil is compared with matched group with high dose Semen Platycladi glycoside, the mice rate of falling asleep is significant difference and (compares with Normal group, P < 0.05), show that it all has facilitation to increasing the rate of falling asleep of injection sub-threshold dose barbital sodium mice.The animal of Semen Platycladi fatty oil high dose falls asleep rate apparently higher than blank group (P < 0.05), though rate is slightly higher than matched group and the animal of basic, normal, high dosage falls asleep, difference is not obvious.The animal of the basic, normal, high dosage of the Semen Platycladi volatile oil animal index of falling asleep is slightly in rising trend with the rising of dosage, but each dosage group is than blank water group, difference is not significantly (through X 2 test) all, and prompting suitably improves dosage, has the fall asleep possibility of rate of remarkable increase animal.The basic, normal, high three dosage groups of Semen Platycladi glycoside are slept number of animals all higher than blank group, wherein more blank group of tool significant difference of high dose Semen Platycladi glycoside group (P < 0.05).In addition,, along with increasing of Semen Platycladi glycoside dosage, sleep number of animals is slightly on the rise.
(3) on the fall asleep impact of number of elements of mice: by Sedative And Hypnotic Effect is tested, observed respectively mice pentobarbital sodium sub-threshold dose hypnosis time and sleep delay time, result is as shown in table 1.With the comparison of blank group, the Semen Platycladi saponin high dose group mice number of elements showed increased of falling asleep, middle low dose group is not obvious.Three dosage groups of oriental arborvitae seed oil have increased mice sleep number of elements to some extent, and wherein low dose group effect is obvious, and the effect of high, middle dosage group is suitable.The impact (X ± S) on the mice number of elements of sleeping under mice threshold of table 12 Semen Platycladi saponin and oriental arborvitae seed oil
(4) barbital sodium Sleep latency experimental result: by national standard method, three kinds of active component in Semen Platycladi are carried out to the experiment of barbital sodium Sleep latency, study its impact on mice time for falling asleep, the results are shown in Table 13.Visible, each dosage group of Semen Platycladi fatty oil is compared with matched group tween group, and mice sleep is all significant difference (P < 0.05) incubation period, shows that Semen Platycladi fatty oil promotes the mice function well of falling asleep.Simultaneously, low, middle dosage Semen Platycladi glycoside also can significantly shorten mice sleep incubation period (P < 0.05), but high dose Semen Platycladi glycoside is than the blank group mice difficulty (though there was no significant difference) of falling asleep slightly, show that low, the middle dosage of this composition shortens mice sleep effect incubation period significantly, dosage is too high may be suppressed mice and fall asleep.In addition, low dosage Semen Platycladi volatile oil is compared with matched group, also can significantly shorten mouse sleep time (P < 0.05).
Table 13 Semen Platycladi composition is on the preclinical impact of mice sleep (X ± S)
Note: with the comparison of blank group, ※ P < 0.05.
The Sleep latency of each dosage group of Semen Platycladi fatty oil and blank tween group compares, all lower than blank tween and have statistical significance (comparing P < 0.05 with matched group); Compare with blank tween group, low dosage Semen Platycladi volatile oil can significantly shorten mice sleep incubation period (P < 0.05), and middle and high dosage group is compared difference with matched group not obvious; Low, the middle dosage mice sleep of Semen Platycladi glycoside incubation period with blank water comparing difference significantly (P < 0.05), this composition high dose group mice sleep incubation period is a little more than blank water group.
(5) extend the pentobarbital sodium experimental result length of one's sleep: by national standard method, three kinds of active component in Semen Platycladi are extended to the pentobarbital sodium experiment length of one's sleep, study its impact on mouse sleep time, the results are shown in Table 14.
Each composition of table 14 Semen Platycladi is on the impact of mouse sleep time (X ± S)
Note: with the comparison of blank group, ※ P < 0.05.
From table 13, middle and high dosage Semen Platycladi volatile oil contrast tween group is compared, mouse sleep time is significant difference and (compares with matched group, P < 0.05), show that it is to extending length of one's sleep of injection pentobarbital sodium mice and have facilitation, though and low dosage Semen Platycladi volatilization line of oils is slightly longer than matched group mouse sleep time, difference is not remarkable, prompting may be inadequate due to dosage, causes its Sleeping Time Prolong Ed action effect inferior to middle and high dosage group.The middle and high dosage group of Semen Platycladi volatile oil mouse sleep time is all apparently higher than blank water group, though low dosage has prolongation trend, but difference is not remarkable, shows the effect of Semen Platycladi volatile oil tool Sleeping Time Prolong Ed, and effect degree and dosage positive correlation.
In sum, high dose Semen Platycladi fatty oil, to improving laboratory animal sleep rate, shortens the equal tool facilitations in aspect such as animal time for falling asleep.
7) microcrystalline Cellulose, consider Caulis et Folium Brassicae capitatae, melatonin, Plumula Nelumbinis, Radix Polygalae, Caulis Polygoni Multiflori, sugary and the higher feature of vitamin of Semen Platycladi, and the operability of the course of processing we selected food additive microcrystalline Cellulose, according to the Zhu Yu of Guangzhou Inst of Chemistry, Chinese Academy of Sciences qin, Tang Liegui, in one one kinds of multi-functional macromolecular material > > mono-literary compositions of < < microcrystalline Cellulose that Pan Songhan delivers on the 3rd phase at < < Chemical Industry in Guangzhou > > the 21st volume in 1993, show: microcrystalline Cellulose can be used as antiplastering aid.Microcrystalline Cellulose addition is 15% of formula, meet GB2760 < < food additive and use sanitary standard > >, microcrystalline Cellulose toxicity ADI does not make particular provisions (FAO/WHO, 1994), make like this its whole formula have more reasonability and science.
More than this specific embodiment several raw materials are mutually auxiliary in whole formula deposits mutually, brings out the best in each other, and makes full side present good effect, and product has obvious enhancing immunity, hypnotic function through function test proof this product.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the technology of the present invention principle; can also make some improvement and modification, these improve and modification also should be considered as protection scope of the present invention.
Claims (1)
1. enhancing immunity, a hypnotic functional health medicine, is characterized in that, made: Caulis et Folium Brassicae capitatae 6-15 by the raw material of following parts by weight, melatonin 6-9, Plumula Nelumbinis extract 4.5-10, Radix Polygalae 1.5-5, Caulis Polygoni Multiflori 4.5-6, Semen Platycladi 4.5-12, microcrystalline Cellulose 3-10.
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| JP2021048806A (en) * | 2019-09-26 | 2021-04-01 | カゴメ株式会社 | Melatonin production promoter and sleep quality improver |
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