CN102512600A - Health product for protecting liver and preparation method thereof - Google Patents

Health product for protecting liver and preparation method thereof Download PDF

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CN102512600A
CN102512600A CN2011104129107A CN201110412910A CN102512600A CN 102512600 A CN102512600 A CN 102512600A CN 2011104129107 A CN2011104129107 A CN 2011104129107A CN 201110412910 A CN201110412910 A CN 201110412910A CN 102512600 A CN102512600 A CN 102512600A
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health product
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radix
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CN102512600B (en
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顾治平
王恒斌
阙瑞艳
陈力建
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CHANGSHU LEIYUNSHANG PHARMACEUTICAL Co Ltd
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CHANGSHU LEIYUNSHANG PHARMACEUTICAL Co Ltd
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Abstract

The invention discloses a health product for protecting liver and a preparation method thereof. The health product for protecting liver is prepared from the following raw materials of: by weight, 1-5 parts of Dendrobium candidum, 3-8 parts of American ginseng and 12-20 parts of root of kudzu vine. It shows through pharmacological experiments that the health product provided by the invention has good effects of protecting liver, effectively raising liver function and promoting hepatocyte restoration and regeneration, has low adverse reactions, and is safe to take. According to the preparation method, the best preparation technology is determined according to physical and chemical property optimization of effective components of each raw material. The preparation method has strong operationality and is suitable for industrial production.

Description

A kind of health product and preparation method thereof with hepatoprotective effect
Technical field
The present invention relates to a kind of health product, be specifically related to a kind of health product and preparation method thereof with hepatoprotective effect.
Background technology
Because excessive, life of life stress or working environment worsen; Cause also being on the increase because of the hepatic injury number that contact chemical poisonous substance (like ethanol or other noxious substances) causes; Especially excessive drinking and alcoholic are increasing; Or the number of being engaged in chemical liver injury among the staff of industries such as chemicals is synthetic, Chemical Manufacture increases gradually; And by the hepatic injury of chemical liver, the acute and chronic hepatitis patients of initiation also increases gradually, has had a strong impact on people's physical and mental health and family, society stable.Medicine or health product that various hepatoprotective are arranged in the market, but itself there are the material of rapid wear liver in existing hepatoprotective medicine or health product in protection people liver, therefore, long-range unsatisfactory curative effect.
Therefore, necessary on the basis of prior art, research and develop a kind of to chemical liver injury have obvious protective effect again safety health product.
Summary of the invention
Goal of the invention: the objective of the invention is to solve the deficiency of prior art, provide a kind of chemical liver injury is had obvious protective effect, determined curative effect, safe and reliable again health product, another object of the present invention provides the method for preparing of these health product.
Technical scheme: in order to realize above purpose, the technical scheme that the present invention taked is:
A kind of health product with hepatoprotective effect, it is processed by the crude drug of following parts by weight: 1 ~ 5 part of Herba Dendrobii, 3 ~ 8 parts of Radix Panacis Quinquefoliis, 12 ~ 20 parts of Radix Puerariaes.
As preferred version, above-described health product with hepatoprotective effect, it is processed by the crude drug of following parts by weight: 1 ~ 2 part of Herba Dendrobii, 3 ~ 5 parts of Radix Panacis Quinquefoliis, 12 ~ 18 parts of Radix Puerariaes.
As most preferred technical scheme, the health product with hepatoprotective effect of the present invention, it is processed by the crude drug of following parts by weight: 1 part of Herba Dendrobii, 3 parts of Radix Panacis Quinquefoliis, 12 parts of Radix Puerariaes.
Health product with hepatoprotective effect provided by the invention can be prepared into oral liquid with acceptable carrier on each extracts of bulk drugs and the food.
When the extract of each raw material of the health product with hepatoprotective effect provided by the invention is processed oral liquid,, filter, add syrup, regulate pH, process oral liquid the extract adding distil water dissolving of each raw material.
Method for preparing with health product of hepatoprotective effect provided by the invention, it may further comprise the steps:
(1) get Herba Dendrobii by weight, pulverize adds the water of 20 to 25 times of amounts, supersound extraction 2 to 3 times, each 30 to 60 minutes, merge extractive liquid, filtered, filtrate decompression concentrates, concentrated solution, subsequent use;
(2) get Radix Panacis Quinquefolii by weight, be cut into segment, adding 6 to 10 times of amount concentration is 65% to 75% ethanol, soaks 12 to 16 hours; Atmospheric pressure reflux is extracted 3 to 5 times, each 1.5 to 2 hours extraction times, merge extractive liquid; Filter, filtrate decompression is concentrated into relative density and is 1 to 1.08, and is subsequent use;
(3) get Radix Puerariae by weight, be cut into segment, adding 7 to 8 times of amount concentration is 45% to 55% ethanol, and atmospheric pressure reflux is extracted 2 to 3 times, and each 1 to 2 hour extraction time, merge extractive liquid, filters, concentrating under reduced pressure, concentrated solution, subsequent use;
Combining step (1), (2) and (3) extract, spray drying gets extract powder.
Above-described method for preparing with health product of hepatoprotective effect, the concentration that step (2) is extracted etoh solvent is 65%, and the time of immersion is 12 hours, and extraction time is 5 times, and each extraction time is 1.5 hours, the spissated relative density of filtrating is 1.08.
Above-described method for preparing with health product of hepatoprotective effect, the concentration that step (3) is extracted etoh solvent is 45%, and extraction time is 3 times, and each extraction time is 1.5 hours.
Method for preparing with health product of hepatoprotective effect provided by the invention; According to the physicochemical property of each active constituents of medicine, confirm its best extraction process through a large amount of experiments, it is high to obtain the extract active component content; Impurity is few; Thereby have good hepatoprotective effect, and the toxic and side effects brought such as free from admixture, take safer.
Health product with hepatoprotective effect provided by the invention according to the physiological function characteristics of health protection with Chinese medicine theory and liver, adopt determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs to carry out compatible combination; Wherein Herba Dendrobii is China's tradition rare Chinese medicine; Has reinforcing stomach reg fluid, nourishing hepatic yin, the effect of nourishing YIN and clearing away heat; Be the nourishing YIN good merchantable brand, but human body immunity improving power.
Radix Panacis Quinquefolii has strengthening by means of tonics, the yin nourishing of nourishing blood, and the effect of invigorating the spleen and benefiting QI is the QI invigorating good merchantable brand, the effect etc. that resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulation property arranged is BA widely.Modern pharmacological research shows that Radix Panacis Quinquefolii saponin also can remove free radical through the protection activity of glutathione peroxidase, reduces free radical and membrane lipid and memebrane protein covalent bond and reaches the hepatoprotective function.
Radix Puerariae is the natural plants of medicine-food two-purpose, and having induces sweat brings down a fever, promote the production of body fluid, rash, relieving restlessness are quenched the thirst, the effect of yang invigorating antidiarrheal.Traditional Chinese medicine theory thinks that function of spleen and stomach regulating fortuneization function is the basic rule of treatment commonly used in the long-term clinical practice of alcoholic liver disease.Radix Puerariae sweet in the mouth, suffering, cool in nature, go into spleen, stomach warp, " sending up the lucid YANG " effect that it has promptly is the function of spleen and stomach regulating function, inspires the taste yang-energy, makes spleen rise stomach and falls, Each performs its own functions and reach and prevent and treat hepatopathy.And modern pharmacological research shows, Radix Puerariae can be through removing oxygen-derived free radicals, and anti peroxidation of lipid improves liver microcirculation etc. and reaches prevention and therapeutical chemistry liver damage.Therefore, these health product science with Herba Dendrobii, Radix Panacis Quinquefolii, Radix Puerariae compatible combination, through QI invigorating, YIN nourishing, promote the production of body fluid, effects such as heat clearing away, strengthening the spleen and stomach, to reach the conditioning liver physiological function, promote liver cell regeneration, play good liver-protective effect.
Beneficial effect: the present invention is according to the physiological function characteristics of Chinese medical theory and liver; Adopt the theory of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs; Formulate the present invention through the science composition of prescription, show that through functional pharmacological evaluation health product provided by the invention have good the liver protecting, improve liver function; Promote hepatocyte to repair and regenerated effect, and drug safety is reliable.Method for preparing with health product of hepatoprotective effect provided by the invention; Deficiency to traditional extraction separation method; According to the special nature with health product crude drug effective ingredient of hepatoprotective effect provided by the invention,, optimize best preparation technology through the system condition orthogonal experiment; Workable, be fit to industrialized great production.
The specific embodiment:
Further illustrate the present invention below in conjunction with specific embodiment; Should understand these embodiment only be used to the present invention is described and be not used in the restriction scope of the present invention; After having read the present invention, those skilled in the art all fall within the application's accompanying claims institute restricted portion to the modification of the various equivalent form of values of the present invention.
Embodiment 1
Crude drug with health product of hepatoprotective effect is formed: 10 kilograms of Herba Dendrobii, 30 kilograms of Radix Panacis Quinquefoliis, 120 kilograms of Radix Puerariaes.
(1) get 10 kilograms of Herba Dendrobii, pulverize adds the water of 25 times of amounts, supersound extraction 3 times, each 30 minutes, merge extractive liquid, filtered, filtrate decompression concentrates, concentrated solution, subsequent use;
(2) get 30 kilograms of Radix Panacis Quinquefoliis, be cut into segment, adding 6 times of amount concentration is 65% ethanol, soaks 12 hours, and atmospheric pressure reflux is extracted 5 times, and each 1.5 hours extraction times, merge extractive liquid, filters, and filtrate decompression is concentrated into relative density and is 1.08, and is subsequent use;
(3) get 120 kilograms of Radix Puerariaes, be cut into segment, adding 7 times of amount concentration is 45% ethanol, and atmospheric pressure reflux is extracted 3 times, and each 1 hour extraction time, merge extractive liquid, filters, concentrating under reduced pressure, concentrated solution, subsequent use;
Combining step (1), (2) and (3) extract, spray drying gets extract powder, and the adding distil water dissolving is filtered, and adds syrup, regulates pH to 7.5, gets oral liquid, and the embedding packing promptly gets.(lot number 2011001)
Embodiment 2
Crude drug with health product of hepatoprotective effect is formed: 20 kilograms of Herba Dendrobii, 50 kilograms of Radix Panacis Quinquefoliis, 180 kilograms of Radix Puerariaes.
(1) get 20 kilograms of Herba Dendrobii, pulverize adds the water of 20 times of amounts, supersound extraction 2 times, each 60 minutes, merge extractive liquid, filtered, filtrate decompression concentrates, concentrated solution, subsequent use;
(2) get 50 kilograms of Radix Panacis Quinquefoliis, be cut into segment, adding 8 times of amount concentration is 75% ethanol, soaks 12 hours, and atmospheric pressure reflux is extracted 3 times, and each 2 hours extraction times, merge extractive liquid, filters, and filtrate decompression is concentrated into relative density and is 1.08, and is subsequent use;
(3) get 180 kilograms of Radix Puerariaes, be cut into segment, adding 8 times of amount concentration is 55% ethanol, and atmospheric pressure reflux is extracted 2 times, and each 2 hours extraction times, merge extractive liquid, filters, concentrating under reduced pressure, concentrated solution, subsequent use;
Combining step (1), (2) and (3) extract, spray drying gets extract powder, and the adding distil water dissolving is filtered, and adds syrup, regulates pH to 7.5, gets oral liquid, and the embedding packing promptly gets.(lot number 2011002)
Embodiment 3
Crude drug with health product of hepatoprotective effect is formed: 50 kilograms of Herba Dendrobii, 80 kilograms of Radix Panacis Quinquefoliis, 200 kilograms of Radix Puerariaes.
(1) get 50 kilograms of Herba Dendrobii, pulverize adds the water of 25 times of amounts, supersound extraction 3 times, each 40 minutes, merge extractive liquid, filtered, filtrate decompression concentrates, concentrated solution, subsequent use;
(2) get 80 kilograms of Radix Panacis Quinquefoliis, be cut into segment, adding 10 times of amount concentration is 65% ethanol, soaks 12 hours, and atmospheric pressure reflux is extracted 2 times, and each 2 hours extraction times, merge extractive liquid, filters, and filtrate decompression is concentrated into relative density and is 1, and is subsequent use;
(3) get 200 kilograms of Radix Puerariaes, be cut into segment, adding 8 times of amount concentration is 45% ethanol, and atmospheric pressure reflux is extracted 3 times, and each 2 hours extraction times, merge extractive liquid, filters, concentrating under reduced pressure, concentrated solution, subsequent use;
Combining step (1), (2) and (3) extract, spray drying gets extract powder, and the adding distil water dissolving is filtered, and adds syrup, regulates pH to 7.5, gets oral liquid, and the embedding packing promptly gets.(lot number 2011003)
Embodiment 4
Crude drug with health product of hepatoprotective effect is formed: 30 kilograms of Herba Dendrobii, 60 kilograms of Radix Panacis Quinquefoliis, 160 kilograms of Radix Puerariaes.
(1) get 30 kilograms of Herba Dendrobii, pulverize adds the water of 25 times of amounts, supersound extraction 3 times, each 30 minutes, merge extractive liquid, filtered, filtrate decompression concentrates, concentrated solution, subsequent use;
(2) get 60 kilograms of Radix Panacis Quinquefoliis, be cut into segment, adding 6 times of amount concentration is 65% ethanol, soaks 12 hours, and atmospheric pressure reflux is extracted 3 times, and each 1.5 hours extraction times, merge extractive liquid, filters, and filtrate decompression is concentrated into relative density and is 1.08, and is subsequent use;
(3) get 160 kilograms of Radix Puerariaes, be cut into segment, adding 7 times of amount concentration is 45% ethanol, and atmospheric pressure reflux is extracted 3 times, and each 2 hours extraction times, merge extractive liquid, filters, concentrating under reduced pressure, concentrated solution, subsequent use;
Combining step (1), (2) and (3) extract, spray drying gets extract powder, and the adding distil water dissolving is filtered, and adds syrup, regulates pH to 7.5, gets oral liquid, and the embedding packing promptly gets.(lot number 2011004)
Embodiment 5: functional pharmacological evaluation
1, CCl 4The pharmacological evaluation of liver injury model
Laboratory animal: 80 of healthy kunming mices, male and female half and half, 15 ~ 25g is divided into 4 groups (two groups of treatment groups, matched group, blank control group), every group of each 20 mice at random
Experimental technique: two treatment group mices give the extract of 0.2g/kg respectively, and (embodiment 1 and embodiment 2 prepare; Thin up to content of dispersion is 0.1g/ml) the filling stomach; Matched group uses the normal saline of same amount to irritate stomach, not medication of blank control group, not modeling; Irritate stomach every day 1 time, continuous irrigation stomach 7 days.1h after the last administration, every group of ip concentration 0.1%CCl 4Soybean oil solution behind fasting 24 h, is got blood, separation of serum, measures Serum ALT, AST; Get hepatic tissue, handle the back and measure the active and MDA content of S0D, it is as shown in table 1 specifically to test structure.
Each group of table 1 is to CCl 4Due to the protective effect of hepatic injury
Group ALT ASL MDA SOD
Blank control group 44.95±8.74 46.86±8.29 9.21±0.47 139.70±22.54
Matched group 189.37±39.81 197.64±41.21 14.59±0.35 88.14±16.55
Embodiment 1 treatment group 78.32±12.57** 92.56±14.38** 10.49±0.21** 118.39±15.18**
Embodiment 2 treatment groups 80.21±8.12** 99.36±10.52* 11.21±0.18** 115.21±12.03**
Compare * P<0.05, * * P<0.01 with matched group
Result of the test by table 1 shows that health product provided by the invention are to CCl 4The ALT of induced mice, AST and MDA raise has tangible reduction effect, and the result shows that health product provided by the invention are to CCl 4Cause that active reduction of SOD has tangible rising effect, shows that health product provided by the invention have the good CCl of improvement 4Due to the hepatic injury effect.
2, the pharmacological evaluation of TAA liver injury model
Laboratory animal: 60 healthy Kunming mouses, male and female half and half, 15 ~ 25g is divided into 3 groups of kinds at random with mice: blank control group (20), embodiment 1 treatment group (20), embodiment 2 treatment groups (20).
Experimental technique: blank control group is irritated stomach equivalent water for injection every day, and two treatment group mices give extract (embodiment 1 and embodiment 2 prepare, and thin up to content of dispersion the is 0.1g/ml) gastric infusion of 0.2g/kg respectively; Two groups of difference lumbar injection thioacetamides (TAA) after 14 days; Water is can't help in fasting, and 24 as a child, and eyeball is got blood; Separation of serum is measured ALT value and ASL value.Concrete experimental result is as shown in table 2:
Table 2 thioacetamide (TAA) liver injury model experimental result
Group Number of animals Dosage The ASL value The ALT value
Blank control group 20 Equivalent water for injection 137.55±34.91 127.55±34.91
Embodiment 1 treatment group 20 0.2g/kg 71.31±9.46* 65.65±10.23**
Embodiment 2 treatment groups 20 0.2g/kg 73.27±10.14* 73.15±11.56*
Compare * P<0.05, * * P<0.01 with matched group
Result of the test by table 2 shows that health product provided by the invention have tangible reduction effect to the ALT of TAA induced mice and the rising of AST, can obviously improve the hepatic injury due to the TAA, and liver is had the significant protection effect.
Carbon tetrachloride (CCl 4) and thioacetamide (TAA) all be the tool reagent that routine is used for the acute liver damage modeling; Wherein carbon tetrachloride mainly through internal metabolism and film dissolution, causes hepatocyte injury, and index ATL, ASL value can obviously improve; And thereby the transhipment of thioacetamide RNA interfering influences protein synthesis; Cause the cell plasma environmental disruption, make hepatic necrosis, index ATL, ASL value etc. also can obviously improve.Experimental result shows that the health product with hepatoprotective effect provided by the invention can effectively resist carbon tetrachloride (CCl 4) and thioacetamide (TAA) due to tentative hepatic injury, the liver protecting free radical scavenging system reduces Serum ALT value, ASL value, alleviates hepatic injury, shows that health product provided by the invention have good liver-protective effect.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; Can also make some improvement and retouching, these improvement and retouching also should be regarded as protection scope of the present invention.

Claims (6)

1. the health product with hepatoprotective effect is characterized in that, it is processed by the crude drug of following parts by weight: 1 ~ 5 part of Herba Dendrobii, 3 ~ 8 parts of Radix Panacis Quinquefoliis, 12 ~ 20 parts of Radix Puerariaes.
2. the health product with hepatoprotective effect according to claim 1 is characterized in that, it is processed by the crude drug of following parts by weight: 1 ~ 2 part of Herba Dendrobii, 3 ~ 5 parts of Radix Panacis Quinquefoliis, 12 ~ 18 parts of Radix Puerariaes.
3. the health product with hepatoprotective effect according to claim 2 is characterized in that, it is processed by the crude drug of following parts by weight: 1 part of Herba Dendrobii, 3 parts of Radix Panacis Quinquefoliis, 12 parts of Radix Puerariaes.
4. claim 1,2 or 3 described method for preparinies with health product of hepatoprotective effect is characterized in that may further comprise the steps:
(1) get Herba Dendrobii by claim 1,2 or 3 said parts by weight, pulverize adds the water of 20 to 25 times of amounts, supersound extraction 2 to 3 times, each 30 to 60 minutes, merge extractive liquid, filtered, filtrate decompression concentrates, concentrated solution, subsequent use;
(2) get Radix Panacis Quinquefolii by claim 1,2 or 3 said parts by weight, be cut into segment, adding 6 to 10 times of amount concentration is 65% to 75% ethanol; Soaked 12 to 16 hours, atmospheric pressure reflux is extracted 3 to 5 times, each 1.5 to 2 hours extraction times; Merge extractive liquid; Filter, filtrate decompression is concentrated into relative density and is 1 to 1.08, and is subsequent use;
(3) get Radix Puerariae by claim 1,2 or 3 said parts by weight, be cut into segment, adding 7 to 8 times of amount concentration is 45% to 55% ethanol, and atmospheric pressure reflux is extracted 2 to 3 times; Each 1 to 2 hour extraction time, merge extractive liquid, filters; Concentrating under reduced pressure gets concentrated solution, and is subsequent use;
Combining step (1), (2) and (3) extract, spray drying gets extract powder, promptly gets.
5. the method for preparing with health product of hepatoprotective effect according to claim 4 is characterized in that, the concentration that step (2) is extracted etoh solvent is 65%; The time of soaking is 12 hours; Extraction time is 5 times, and each extraction time is 1.5 hours, and the spissated relative density of filtrating is 1.08.
6. the method for preparing with health product of hepatoprotective effect according to claim 4 is characterized in that, the concentration that step (3) is extracted etoh solvent is 45%, and extraction time is 3 times, and each extraction time is 1.5 hours.
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CN105053117A (en) * 2015-09-17 2015-11-18 合肥微信片农业科技有限公司 High-calcium dendrobium nutrition bread
CN105126026A (en) * 2015-09-11 2015-12-09 无限极(中国)有限公司 Traditional Chinese medicinal composition with hepatoprotective effect, and preparation method and application of traditional Chinese medicinal composition
CN105535544A (en) * 2016-01-15 2016-05-04 东莞广州中医药大学中医药数理工程研究院 Medicine or health care product containing herba dendrodii officinalis
CN105747217A (en) * 2016-03-09 2016-07-13 贵州省生物研究所 Dendrobium candidum composition and application and preparation method thereof
CN106177494A (en) * 2016-08-10 2016-12-07 中国科学院城市环境研究所 A kind of Herba Dendrobii extract buccal tablet and preparation method thereof
CN108936630A (en) * 2018-08-07 2018-12-07 九仙尊霍山石斛股份有限公司 A kind of Dendrobidium huoshanness turmeric radix puerariae capsule and preparation method
CN109329941A (en) * 2018-12-19 2019-02-15 九仙尊霍山石斛股份有限公司 A kind of Dendrobidium huoshanness relieves the effect of alcohol particle and preparation method thereof
CN115607629A (en) * 2022-10-28 2023-01-17 南京中医药大学 A Chinese medicinal composition with liver protecting and hangover relieving effects, and its preparation method

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105126026A (en) * 2015-09-11 2015-12-09 无限极(中国)有限公司 Traditional Chinese medicinal composition with hepatoprotective effect, and preparation method and application of traditional Chinese medicinal composition
US10799549B2 (en) 2015-09-11 2020-10-13 Infinitus (China) Company Ltd. Hepatoprotective traditional chinese medicine composition containing fructus ligustri lucidi, herba exliptae, radix paeoniae alba, rhizoma curcumae longae and clam extract, preparation method and use thereof
CN105053117A (en) * 2015-09-17 2015-11-18 合肥微信片农业科技有限公司 High-calcium dendrobium nutrition bread
CN105535544A (en) * 2016-01-15 2016-05-04 东莞广州中医药大学中医药数理工程研究院 Medicine or health care product containing herba dendrodii officinalis
CN105747217A (en) * 2016-03-09 2016-07-13 贵州省生物研究所 Dendrobium candidum composition and application and preparation method thereof
CN106177494A (en) * 2016-08-10 2016-12-07 中国科学院城市环境研究所 A kind of Herba Dendrobii extract buccal tablet and preparation method thereof
CN108936630A (en) * 2018-08-07 2018-12-07 九仙尊霍山石斛股份有限公司 A kind of Dendrobidium huoshanness turmeric radix puerariae capsule and preparation method
CN109329941A (en) * 2018-12-19 2019-02-15 九仙尊霍山石斛股份有限公司 A kind of Dendrobidium huoshanness relieves the effect of alcohol particle and preparation method thereof
CN115607629A (en) * 2022-10-28 2023-01-17 南京中医药大学 A Chinese medicinal composition with liver protecting and hangover relieving effects, and its preparation method
CN115607629B (en) * 2022-10-28 2023-12-05 南京中医药大学 Traditional Chinese medicine composition with liver protecting and alcohol effect dispelling functions and preparation method thereof

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