CN102507566B - Group detection method, reagent box and detection device for clinical biochemical samples - Google Patents
Group detection method, reagent box and detection device for clinical biochemical samples Download PDFInfo
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- CN102507566B CN102507566B CN 201110393230 CN201110393230A CN102507566B CN 102507566 B CN102507566 B CN 102507566B CN 201110393230 CN201110393230 CN 201110393230 CN 201110393230 A CN201110393230 A CN 201110393230A CN 102507566 B CN102507566 B CN 102507566B
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Abstract
The invention relates to a medical detection method and a medical detection device, in particular to a group detection method, a reagent box and a detection device for clinical biochemical samples. The detection method includes: a, arranging an R1 reagent box and an R2 reagent box, wherein the reagent box R1 comprises a plurality of R1 reagent cavities which are sequentially arrayed and connected into a whole, and the R2 reagent box comprises a plurality of R2 reagent cavities which are sequentially arrayed and connected into a whole; b, sequentially adding R1 reagents into the R1 reagent cavities of the R1 reagent box and closing the R1 reagent box to form the R1 reagent box containing all R1 reagents of a certain detection item group, and sequentially adding R2 reagents into the R2 reagent cavities of the R2 reagent box and closing the R2 reagent box to form the R2 reagent box containing all R2 reagents of a certain detecting item group; and c, completing a group detection item by the aid of the R1 reagent box and the R2 reagent box in each pair. By the aid of the detection method, automatic detecting equipment can be simplified, and the group detection item is conveniently detected.
Description
Technical field
The present invention relates to medical detection method and device, specifically is a kind of clinical biochemical sample detection method, kit and pick-up unit in groups.
Background technology
In the clinical examination, usually divide into groups by function (as renal function, liver function etc.) according to clinical needs for test item, each group test item comprises a plurality of single test items, the project team that for example carries out the renal function detection comprises single test items such as CRE flesh liver, ALB albumin, T-PRO total protein, UA uric acid, BUN urea nitrogen, each single test item generally adopts " double reagent ", that is: before detection, add first reagent (this area is commonly referred to as R1 reagent) earlier, make it with sample in chaff interference reaction; Add second reagent (this area is commonly referred to as R2 reagent) again, formal and example reaction begins.Existing automatic checkout equipment is in order to satisfy the requirement of multiple test item in groups, normally in equipment, be equipped with the container of various R1 reagent of a plurality of storages and R2 reagent, according to different test items all ingredients is matched then, after R1 reagent and R2 reagent and test sample reaction, reactant liquor system's (as colorimetric system etc.) after testing carries out the detection of final test index.When this method is applied to automatic checkout equipment, make the entire equipment complex structure, move and operation inconvenience, be not easy in the open air, the automatic detection under the maneuvering condition, also be not easy to targetedly particular detection project team be carried out a large amount of duplicate detection.
Summary of the invention
Technical matters to be solved by this invention is, provide a kind of and simplify automatic checkout equipment, be convenient to clinical biochemical sample that test item is in groups detected in groups detection method and the detection kit in groups that can be used for this method with become set detecting device.
Clinical biochemical sample of the present invention detection method in groups is:
A., a R1 kit and a R2 kit are set; The R1 kit is made up of a plurality of R1 reagent chamber that are arranged in order and be connected as a single entity; The R2 kit is made up of a plurality of R2 reagent chamber that are arranged in order and be connected as a single entity;
B. employed first reaction reagent of each single test item is as R1 reagent in groups in the test item at one, and second reaction reagent is as R2 reagent; With this in groups the R1 reagent of each the single test item in the test item add in each R1 reagent chamber of a R1 kit successively and sealing, constitute a R1 kit that has comprised a certain all R1 reagent of test item group; With this in groups the R2 reagent of each the single test item in the test item add in each R2 reagent chamber of R2 kit successively and sealing, constitute a R2 kit that has comprised a certain all R2 reagent of test item group;
C. each is used to finish a test item in groups to R1 kit and R2 kit, concrete testing process is: testing sample is joined in each R1 reagent chamber and the R1 reagent reacting, extract R2 reagent in each R2 reagent chamber successively by sampler then, and R2 reagent is injected in each the R1 reagent chamber that matches, with reactant liquor behind testing sample and R1 reagent reacting hybrid reaction once more; After reaction is finished with each R1 reagent chamber of R1 kit as cuvette, successively by the colorimetric proving installation, carry out the colorimetric test, obtain testing result.
Described each R2 reagent chamber can with one or more R1 reagent chamber carry out supporting, to reduce the quantity of R2 reagent chamber.
Clinical biochemical sample of the present invention detection kit in groups includes a R1 kit and a R2 kit; The box body of R1 kit is made up of a plurality of R1 reagent chamber that are arranged in order and be connected as a single entity; The box body of R2 kit is made up of a plurality of R2 reagent chamber that are arranged in order and be connected as a single entity; Be packaged with the R1 reagent of each single test item in a certain test item in groups in each R1 reagent chamber successively; Be packaged with the R1 reagent of each single test item in the described test item in groups in each R2 reagent chamber successively; The R2 kit of a specific project can be with a plurality of supporting with the corresponding R1 kit of specific project according to what of packaged amount of reagent; Each R1 reagent chamber of described R1 kit all is to test the cuvette of usefulness independently as colorimetric.
Also be provided with the cavity body that can be used for placing testing sample on the described R1 kit.
Clinical biochemical sample of the present invention becomes set detecting device to include above-mentioned R1 kit and R2 kit, also includes the colorimetric proving installation that detects based on colourimetry and the sampling mechanism of be used for extracting and annotate sample or reagent; The R1 kit can drive it by drive unit and move and make each R1 reagent chamber alternately be positioned at the test position of colorimetric proving installation.
In the above-mentioned one-tenth set detecting device, described sampling mechanism includes a swivel arm that can rotate around the axis, and the sample introduction needle that can move as circumference with the rotation of swivel arm is installed on the described swivel arm, sample introduction needle can extract and annotate sample or reagent; The circumference motion track of the motion track of described R1 reagent chamber and sample introduction needle has intersection point; R2 reagent chamber on the described R2 kit is arranged on the circumference motion track of sample introduction needle along circular arc.Also be provided with on the circumference motion track of described sample introduction needle and be used for extracting the sample position of testing sample and being used for after each sample introduction finishes, cleaning the cleaning position of sample introduction needle for sample introduction needle.Sample can be arranged on the sample position, also can be arranged in the described cavity body of reserving in the R1 kit.
Advantage applies of the present invention exists:
1, adopts the inventive method and device, can realize that the multinomial order of single biochemical blood sample measures immediately, the biological sample that can satisfy under the emergency treatment situation is measured, particularly compare with the dry type biochemical method, the present invention has realized the instant measurement based on the wet type biochemical method, and its accuracy, repeatability all are higher than the instrument that adopts the dry type biochemical method.
2, adopt surveying instrument of the present invention or device, its volume significantly dwindles, and structure obtains simplifying, and reliability increases, and is easy to safeguard, can be used to flow, the field operations occasion, has the advantage that large automatic instrument can't be compared.
3, adopt surveying instrument of the present invention or device, because reagent adopts in groups quantitatively encapsulation, almost not waste, it is biochemical approaching but significantly be lower than the measurement cost of dry type biochemistry that it detects cost and common wet type.
4, because reagent of the present invention quantitatively encapsulation in groups can be calibrated in batches by factory, and the Electronic Calibration parameter is provided, simplified calibration procedure, the user is easy to use, and the calibration object of the costliness of having used when having saved actual detected simultaneously reduces cost.
Description of drawings
Fig. 1 is the structural representation that clinical biochemical sample of the present invention becomes set detecting device embodiment.
Embodiment
As shown in the figure, clinical biochemical sample of the present invention becomes set detecting device to include R1 kit 1 and R2 kit 2; The box body of R1 kit 1 is made up of a plurality of R1 reagent chamber 11 that are arranged in order and be connected as a single entity; The box body of R2 kit 2 is made up of a plurality of R2 reagent chamber 21 that are arranged in order and be connected as a single entity; Be packaged with the R1 reagent of each single test item in a certain test item in groups in each R1 kit 1 successively; Be packaged with the R2 reagent of each single test item in the described test item in groups in each R2 kit 2 successively; Each R1 reagent chamber 2 of R1 kit 1 all can be independently as the cuvette of colorimetric proving installation.This device also includes the colorimetric proving installation 3 that detects based on colourimetry and the sampling mechanism of be used for extracting and annotate sample or reagent; R1 kit 1 can drive it by drive unit and move and make each R1 reagent chamber 11 alternately be positioned at the test position 31 of colorimetric proving installation 3.Among this embodiment, sampling mechanism includes a swivel arm that can rotate around the axis 41, and the sample introduction needle 42 that can move as circumference with the rotation of swivel arm is installed on the swivel arm, sample introduction needle can extract and annotate sample or reagent; The circumference motion track of the motion track of R1 reagent chamber 11 and sample introduction needle 42 has intersection point; R2 reagent chamber 21 on the R2 kit 2 is arranged on the circumference motion track of sample introduction needle 42 along circular arc.Also be provided with on the circumference motion track of sample introduction needle 42 and be used for extracting the sample position 5 of testing sample and being used for after each sample introduction finishes, cleaning the cleaning position 6 of sample introduction needle for sample introduction needle.
Biological sample of the present invention becomes the formation of set detecting device and using method to be:
A., a R1 kit 1 and a R2 kit 2 are set; The R1 kit is made up of a plurality of R1 reagent chamber 11 that are arranged in order and be connected as a single entity; The R2 kit is made up of a plurality of R1 reagent chamber 21 that are arranged in order and be connected as a single entity;
B. employed first reaction reagent of each single test item is as R1 reagent in groups in the test item at one, and second reaction reagent is as R2 reagent; With this in groups the R1 reagent of each the single test item in the test item add in each R1 reagent chamber of a R1 kit successively and sealing, constitute a R1 kit that has comprised a certain all R1 reagent of test item group; With this in groups the R2 reagent of each the single test item in the test item add in each R2 reagent chamber of R2 kit successively and sealing, constitute a R2 kit that has comprised a certain all R2 reagent of test item group;
C. each is used to finish a test item in groups to R1 kit and R2 kit, concrete testing process is: testing sample is joined in each R1 reagent chamber and the R1 reagent reacting, extract R2 reagent in each R2 reagent chamber successively by sampler then, and R2 reagent is injected in each the R1 reagent chamber that matches, with R1 reagent and the mixed reactant liquor of testing sample hybrid reaction once more; After reaction is finished with each R1 reagent chamber 11 of R1 kit as cuvette successively by the test position 31 of colorimetric proving installation 3, carry out the colorimetric test, obtain testing result.The colorimetric proving installation generally includes the light source that is positioned at test position one side and is positioned at the signal of testing the position opposite side and receives and processing module.Each R2 kit can with one or more R1 kits carry out supporting, to reduce the quantity of R2 kit.
Claims (7)
1. clinical biochemical sample detection method in groups is characterized in that:
A., a R1 kit and a R2 kit are set; The R1 kit is made up of a plurality of R1 reagent chamber that are arranged in order and be connected as a single entity; The R2 kit is made up of a plurality of R2 reagent chamber that are arranged in order and be connected as a single entity;
B. employed first reaction reagent of each single test item is as R1 reagent in groups in the test item at one, and second reaction reagent is as R2 reagent; With this in groups the R1 reagent of each the single test item in the test item add in each R1 reagent chamber of a R1 kit successively and sealing, constitute a R1 kit that has comprised a certain all R1 reagent of test item group; With this in groups the R2 reagent of each the single test item in the test item add in each R2 reagent chamber of R2 kit successively and sealing, constitute a R2 kit that has comprised a certain all R2 reagent of test item group;
C. each is used to finish a test item in groups to R1 kit and R2 kit, concrete testing process is: testing sample is joined in each R1 reagent chamber and the R1 reagent reacting, extract R2 reagent in each R2 reagent chamber successively by sampler then, and R2 reagent is injected in each the R1 reagent chamber that matches, with reactant liquor behind testing sample and R1 reagent reacting hybrid reaction once more; After reaction is finished each R1 reagent chamber of R1 kit is passed through the colorimetric proving installation successively as cuvette, carry out the colorimetric test, obtain testing result.
2. clinical biochemical sample according to claim 1 is detection method in groups, it is characterized in that: each R2 reagent chamber and one or more R1 reagent chamber are carried out supporting.
3. clinical biochemical sample detection kit in groups, it is characterized in that: it includes a R1 kit (1) and a R2 kit (2); The box body of R1 kit (1) is made up of a plurality of R1 reagent chamber (11) that are arranged in order and be connected as a single entity; The box body of R2 kit (2) is made up of a plurality of R2 reagent chamber (21) that are arranged in order and be connected as a single entity; Be packaged with the R1 reagent of each single test item in a certain test item in groups in each R1 reagent chamber (11) successively; Be packaged with the R2 reagent of each single test item in the described test item in groups in each R2 kit (2) successively; Each R1 reagent chamber (11) of R1 kit (1) all is to test the cuvette of usefulness independently as colorimetric.
4. clinical biochemical sample according to claim 3 is detection kit in groups, it is characterized in that: described R1 kit is provided with cavity body.
5. a clinical biochemical sample becomes set detecting device, it is characterized in that: it includes claim 3 or 4 described clinical biochemical samples detection kit in groups, also includes the colorimetric proving installation (3) that detects based on colourimetry and the sampling mechanism of be used for extracting and annotate sample or reagent; R1 kit (1) can drive it by drive unit and move and make each R1 reagent chamber (11) alternately be positioned at the test position (31) of colorimetric proving installation (3).
6. clinical biochemical sample according to claim 5 becomes set detecting device, it is characterized in that: described sampling mechanism includes a swivel arm that can rotate around the axis (41), the sample introduction needle (42) that can move as circumference with the rotation of swivel arm is installed, sample introduction needle can extract and annotate sample or reagent on the swivel arm; The circumference motion track of the motion track of R1 reagent chamber (11) and sample introduction needle (42) has intersection point; R2 reagent chamber (21) on the R2 kit (2) is arranged on the circumference motion track of sample introduction needle (42) along circular arc.
7. clinical biochemical sample according to claim 6 becomes set detecting device, it is characterized in that: also be provided with the cleaning position (6) that is used for supplying sample introduction needle to extract the sample position (5) of testing sample and is used for finishing back cleaning sample introduction needle on the circumference motion track of described sample introduction needle (42) at each sample introduction.
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| CN103412130A (en) * | 2013-08-22 | 2013-11-27 | 四川省新成生物科技有限责任公司 | Reagent cup assembly, instrument and method for quickly determining content of specific proteins of urine |
| CN105203781A (en) * | 2015-09-16 | 2015-12-30 | 江苏奥迪康医学科技股份有限公司 | Clinical chemistry integrated and combined multi-reagent-strip detection device and method |
| CN106018768A (en) * | 2016-05-31 | 2016-10-12 | 四川金域医学检验中心有限公司 | Multi-project biochemical examination and analysis integrated kit |
| CN109321451B (en) * | 2018-10-11 | 2021-08-10 | 常州市环境监测中心 | Zebra fish embryo acute toxicity detection kit for multiple groups of experiments |
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Address after: 212009 Zhenjiang city Jiangsu province area Dingmao latitude four Road No. 36 high tech Industrial Park, No. 4 Building 4 layer Patentee after: JIANGSU AUDICOM MEDICAL TECHNOLOGY CO., LTD. Address before: 212009 Zhenjiang city Jiangsu province area Dingmao latitude four Road No. 36 high tech Industrial Park, No. 4 Building 4 layer Patentee before: Jiangsu Audicom Medical Technology Co., Ltd. |