CN102485184A - Nanometer silver antibacterial biliary duct bracket and preparation method thereof - Google Patents
Nanometer silver antibacterial biliary duct bracket and preparation method thereof Download PDFInfo
- Publication number
- CN102485184A CN102485184A CN2010105721658A CN201010572165A CN102485184A CN 102485184 A CN102485184 A CN 102485184A CN 2010105721658 A CN2010105721658 A CN 2010105721658A CN 201010572165 A CN201010572165 A CN 201010572165A CN 102485184 A CN102485184 A CN 102485184A
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- Prior art keywords
- biliary tract
- tract prosthesis
- nanometer silver
- plastics
- prosthesis
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Abstract
The invention relates to a nanometer silver antibacterial biliary duct bracket and a preparation method thereof. The nanometer silver antibacterial biliary duct bracket belongs to a medical appliance, in particular to a medical biliary duct bracket for human bodies. The nanometer silver antibacterial biliary duct bracket comprises a plastic biliary duct bracket, wherein a nanometer silver deposition layer with the nanometer silver particle size being 0.5 to 200cn is uniformly attached on the inner and outer wall surfaces of the plastic biliary duct bracket. Compared with the prior art, the nanometer silver antibacterial biliary duct bracket has the advantages that the attaching of the stable nanometer silver coating on the existing medical bracket can be realized, silver ions are continuously released for realizing the antibacterial effect on intestine liquid, the secondary infection is prevented, in addition, the problem of medical bracket blockage is avoided.
Description
Technical field
The invention belongs to medical apparatus, is the medical biliary tract prosthesis that is used for human body.Relate to a kind of nanometer silver antimicrobial biliary tract prosthesis and preparation method thereof.
Background technology
Clinical, under the scope in the implant into body bile duct be one of effective ways of minimally-invasive treatment gallbladder leakage with medical support, simple.In the prior art, medical support is all used plastics and is processed, and after the long-term implant into body of this medical support is interior, owing to there is the intestinal juice adverse current of escherichia coli and other antibacterial to get into bile duct, is to cause the main cause of secondary infection to cause medical support to block.Caused great trouble and misery for patient's medical treatment and life.Therefore, how to make existing medical support have antibacterial action, preventing secondary infection and avoiding medical support to block is current a great problem clinically.The relevant report that domestic and international technical literature is not all seen the biliary tract prosthesis with antibacterial action.
Summary of the invention
Have this great difficult problem of antibacterial action in order to solve the biliary tract prosthesis that is used for human body, the purpose of this invention is to provide a kind of nanometer silver antimicrobial biliary tract prosthesis and preparation method thereof.It can be implemented on the existing medical support adheres to the stabilized nano silver coating, continues to discharge silver ion to play the antibacterial action to intestinal juice, the problem that can prevent secondary infection and avoid medical support to block.
In order to realize above-mentioned goal of the invention, technical scheme of the present invention realizes as follows.
A kind of nanometer silver antimicrobial biliary tract prosthesis, it comprises the plastics biliary tract prosthesis.Its construction features is that the inside and outside wall of said plastics biliary tract prosthesis evenly is attached with the nanometer silver sedimentary deposit.
In above-mentioned nanometer silver antimicrobial biliary tract prosthesis, the nano-Ag particles of said nanometer silver sedimentary deposit size is 0.5-200nm.
The method for preparing of above-mentioned nanometer silver antimicrobial biliary tract prosthesis the steps include:
1. the plastics biliary tract prosthesis was soaked several minutes in analytical pure (anhydrous) ethanol;
2. the plastics biliary tract prosthesis being put into sodium, naphthalene and oxolane corrosive liquid soaks;
3. the plastics biliary tract prosthesis is fully cleaned with secondary deionized water;
4. the plastics biliary tract prosthesis is put into the diluted nitric acid aqueous solution immersion or used hydrogen peroxide
Aqueous solution and other strong oxidizer carry out oxidation;
5. the plastics biliary tract prosthesis is fully cleaned with secondary deionized water;
6. the plastics biliary tract prosthesis is put into SnCl
2Soak in the aqueous solution;
7. the plastics biliary tract prosthesis is put into ammonia, AgNO
3React in the aqueous solution, it
The back is incubated in water-bath;
8. the plastics biliary tract prosthesis is fully cleaned with secondary deionized water;
9. with the dehydration of plastics biliary tract prosthesis, sterile packaged afterwards.
The present invention has been owing to adopted above-mentioned structure, evenly is attached with the nanometer silver sedimentary deposit at the inside and outside wall of existing medical biliary tract prosthesis.When with it behind implant into body bile duct under the scope, it can continue to discharge silver ion to play the antibacterial action to intestinal juice, has effectively prevented secondary infection and has avoided the obstructing problem of medical support.
With the nanometer silver biliary tract prosthesis that method for preparing of the present invention is made, internal and external walls can evenly be adhered to nanometer silver.The nano-Ag particles controlled amount, as required, the big I of nano-Ag particles reaches 0.5-200nm.Nano-silver layer controllable thickness and nanometer silver sedimentary deposit are reliable and stable.Through detecting, indexs such as the elasticity of nanometer silver biliary tract prosthesis of the present invention, coefficient of friction change difference does not have the statistical significance in the practical application.That is to say very little use that does not influence clinically of its variation, have popularizing value very widely.
Description of drawings
Accompanying drawing is a structural representation of the present invention.
The specific embodiment
Referring to accompanying drawing, nanometer silver antimicrobial biliary tract prosthesis of the present invention comprises plastics biliary tract prosthesis 1, and the inside and outside wall of plastics biliary tract prosthesis 1 evenly is attached with the nano-Ag particles size and is the nanometer silver sedimentary deposit 2 of 0.5-200nm.
The method for preparing of nanometer silver antimicrobial biliary tract prosthesis of the present invention the steps include:
1. plastics biliary tract prosthesis 1 was soaked several minutes in analytical pure (anhydrous) ethanol;
2. plastics biliary tract prosthesis 1 being put into sodium, naphthalene and oxolane corrosive liquid soaks;
3. plastics biliary tract prosthesis 1 usefulness secondary deionized water is fully cleaned;
4. plastics biliary tract prosthesis 1 is put into the diluted nitric acid aqueous solution immersion or used peroxidating
Aqueous solution of hydrogen and other strong oxidizer carry out oxidation;
5. plastics biliary tract prosthesis 1 usefulness secondary deionized water is fully cleaned;
6. plastics biliary tract prosthesis 1 is put into SnCl
2Soak in the aqueous solution;
7. plastics biliary tract prosthesis 1 is put into ammonia, AgNO
3React in the aqueous solution,
In water-bath, be incubated afterwards;
8. plastics biliary tract prosthesis 1 usefulness secondary deionized water is fully cleaned;
9. with plastics biliary tract prosthesis 1 dehydration, sterile packaged afterwards.
The present invention can put into the needs of the time length of human body according to support in the production process of reality, manufacture the nanometer silver antimicrobial biliary tract prosthesis of different-thickness sedimentary deposit.Such as transferring ammonia, AgNO
3The concentration of solution is perhaps earlier with rarer ammonia, AgNO
3Solution reacts, and the method for reuse electrochemical deposition is regulated the thickness of Ag sedimentary deposit afterwards.But the Ag sedimentary deposit can not be too thick, otherwise biliary tract prosthesis becomes too hard, promptly can't be applied in the human body.
Claims (3)
1. nanometer silver antimicrobial biliary tract prosthesis, it comprises plastics biliary tract prosthesis (1), it is characterized in that, the inside and outside wall of said plastics biliary tract prosthesis (1) evenly is attached with nanometer silver sedimentary deposit (2).
2. according to the described nanometer silver antimicrobial biliary tract prosthesis of claim 1, it is characterized in that the nano-Ag particles size of said nanometer silver sedimentary deposit (2) is 0.5-200nm.
3. according to the method for preparing of the described nanometer silver antimicrobial biliary tract prosthesis of claim 1, the steps include:
1. the plastics biliary tract prosthesis was soaked several minutes in analytical pure (anhydrous) ethanol;
2. the plastics biliary tract prosthesis being put into sodium, naphthalene and oxolane corrosive liquid soaks;
3. the plastics biliary tract prosthesis is fully cleaned with secondary deionized water;
4. the plastics biliary tract prosthesis is put into the diluted nitric acid aqueous solution immersion or used hydrogen peroxide
Aqueous solution and other strong oxidizer carry out oxidation;
5. the plastics biliary tract prosthesis is fully cleaned with secondary deionized water;
6. the plastics biliary tract prosthesis is put into SnCl
2Soak in the aqueous solution;
7. the plastics biliary tract prosthesis is put into ammonia, AgNO
3React in the aqueous solution, in water-bath, be incubated afterwards;
8. the plastics biliary tract prosthesis is fully cleaned with secondary deionized water;
9. with the dehydration of plastics biliary tract prosthesis, sterile packaged afterwards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105721658A CN102485184A (en) | 2010-12-03 | 2010-12-03 | Nanometer silver antibacterial biliary duct bracket and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105721658A CN102485184A (en) | 2010-12-03 | 2010-12-03 | Nanometer silver antibacterial biliary duct bracket and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102485184A true CN102485184A (en) | 2012-06-06 |
Family
ID=46150780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105721658A Pending CN102485184A (en) | 2010-12-03 | 2010-12-03 | Nanometer silver antibacterial biliary duct bracket and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102485184A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721299A (en) * | 2013-12-11 | 2014-04-16 | 虞桂平 | Functional device for thoracic surgery department |
| CN104147642A (en) * | 2014-07-29 | 2014-11-19 | 复旦大学附属华山医院 | Method for preparing anti-infectious artificial ligament |
| CN104846355A (en) * | 2015-04-16 | 2015-08-19 | 山东省千佛山医院 | Anti-deposition nanometer silver particle coating biliary stent and preparation method thereof |
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| CN1775191A (en) * | 2005-11-26 | 2006-05-24 | 商丘雅康药械有限公司 | Nano silver intrauterine device |
| WO2006133336A2 (en) * | 2005-06-07 | 2006-12-14 | Cardiomind, Inc. | Conformable ten-thousandths scale metal reinforced stent delivery guide sheath or restraint |
| EP1626749B1 (en) * | 2003-05-28 | 2008-10-08 | Cinvention Ag | Implants comprising functionalized carbon surfaces |
| CN101460200A (en) * | 2006-04-07 | 2009-06-17 | 防菌公司 | A substrate having an electron donating surface with metal particles comprising palladium on said surface |
| CN101883663A (en) * | 2007-10-16 | 2010-11-10 | Hkpb科技有限公司 | Surface coating processes and uses of same |
| CN202015266U (en) * | 2010-12-03 | 2011-10-26 | 令狐恩强 | Nanosilver antibacterial biliary duct scaffold |
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2010
- 2010-12-03 CN CN2010105721658A patent/CN102485184A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1626749B1 (en) * | 2003-05-28 | 2008-10-08 | Cinvention Ag | Implants comprising functionalized carbon surfaces |
| WO2006133336A2 (en) * | 2005-06-07 | 2006-12-14 | Cardiomind, Inc. | Conformable ten-thousandths scale metal reinforced stent delivery guide sheath or restraint |
| CN1775191A (en) * | 2005-11-26 | 2006-05-24 | 商丘雅康药械有限公司 | Nano silver intrauterine device |
| CN101460200A (en) * | 2006-04-07 | 2009-06-17 | 防菌公司 | A substrate having an electron donating surface with metal particles comprising palladium on said surface |
| CN101883663A (en) * | 2007-10-16 | 2010-11-10 | Hkpb科技有限公司 | Surface coating processes and uses of same |
| CN202015266U (en) * | 2010-12-03 | 2011-10-26 | 令狐恩强 | Nanosilver antibacterial biliary duct scaffold |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721299A (en) * | 2013-12-11 | 2014-04-16 | 虞桂平 | Functional device for thoracic surgery department |
| CN103721299B (en) * | 2013-12-11 | 2015-11-25 | 虞桂平 | A kind of function utensil for thoracic surgery |
| CN104147642A (en) * | 2014-07-29 | 2014-11-19 | 复旦大学附属华山医院 | Method for preparing anti-infectious artificial ligament |
| CN104147642B (en) * | 2014-07-29 | 2016-07-20 | 复旦大学附属华山医院 | The preparation method of infection artificial ligament |
| CN104846355A (en) * | 2015-04-16 | 2015-08-19 | 山东省千佛山医院 | Anti-deposition nanometer silver particle coating biliary stent and preparation method thereof |
| CN104846355B (en) * | 2015-04-16 | 2017-09-29 | 山东省千佛山医院 | A kind of nano silver particles coating biliary tract prosthesis of antagonism deposition and preparation method thereof |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20151202 |
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| C20 | Patent right or utility model deemed to be abandoned or is abandoned |