CN102481009A - 包含外源性核苷酸的营养组合物 - Google Patents

包含外源性核苷酸的营养组合物 Download PDF

Info

Publication number: CN102481009A
Authority: CN; China
Prior art keywords: alimentation composition; combination; alimentation; exogenous nucleotides; mammal
Prior art date: 2009-08-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN2010800405864A

Other languages

English (en)

Chinese (zh)

Inventor

诺曼·阿兰·格林博格

道格拉斯·理查德·博尔斯特

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nestec SA

Original Assignee

Societe dAssistance Technique pour Produits Nestle SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-08-13

Filing date

2010-08-09

Publication date

2012-05-30

2010-08-09 Application filed by Societe dAssistance Technique pour Produits Nestle SA filed Critical Societe dAssistance Technique pour Produits Nestle SA

2012-05-30 Publication of CN102481009A publication Critical patent/CN102481009A/zh

Status Pending legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 89
239000002773 nucleotide Substances 0.000 title claims abstract description 41
125000003729 nucleotide group Chemical group 0.000 title claims abstract description 41
235000016709 nutrition Nutrition 0.000 title claims abstract description 17
238000000034 method Methods 0.000 claims abstract description 42
241000124008 Mammalia Species 0.000 claims description 15
241000222120 Candida <Saccharomycetales> Species 0.000 claims description 11
235000018102 proteins Nutrition 0.000 claims description 11
102000004169 proteins and genes Human genes 0.000 claims description 11
108090000623 proteins and genes Proteins 0.000 claims description 11
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10
235000015097 nutrients Nutrition 0.000 claims description 10
241000605909 Fusobacterium Species 0.000 claims description 9
235000001014 amino acid Nutrition 0.000 claims description 8
229940024606 amino acid Drugs 0.000 claims description 8
150000001413 amino acids Chemical class 0.000 claims description 8
230000015556 catabolic process Effects 0.000 claims description 8
235000013406 prebiotics Nutrition 0.000 claims description 8
210000002460 smooth muscle Anatomy 0.000 claims description 8
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 8
-1 glucose oligosaccharide Chemical class 0.000 claims description 7
230000017854 proteolysis Effects 0.000 claims description 7
241000193798 Aerococcus Species 0.000 claims description 6
241000193830 Bacillus <bacterium> Species 0.000 claims description 6
241000606125 Bacteroides Species 0.000 claims description 6
241000186000 Bifidobacterium Species 0.000 claims description 6
241001478240 Coccus Species 0.000 claims description 6
241000194033 Enterococcus Species 0.000 claims description 6
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
241000186660 Lactobacillus Species 0.000 claims description 6
241000194036 Lactococcus Species 0.000 claims description 6
241000192132 Leuconostoc Species 0.000 claims description 6
241000192041 Micrococcus Species 0.000 claims description 6
241000235395 Mucor Species 0.000 claims description 6
241000192001 Pediococcus Species 0.000 claims description 6
241000228143 Penicillium Species 0.000 claims description 6
241000235648 Pichia Species 0.000 claims description 6
241000186429 Propionibacterium Species 0.000 claims description 6
241000235527 Rhizopus Species 0.000 claims description 6
241000191940 Staphylococcus Species 0.000 claims description 6
241000194017 Streptococcus Species 0.000 claims description 6
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims description 6
239000003963 antioxidant agent Substances 0.000 claims description 6
230000003078 antioxidant effect Effects 0.000 claims description 6
235000006708 antioxidants Nutrition 0.000 claims description 6
229940039696 lactobacillus Drugs 0.000 claims description 6
229920001542 oligosaccharide Polymers 0.000 claims description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 5
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 5
229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5
230000008859 change Effects 0.000 claims description 5
239000008103 glucose Substances 0.000 claims description 5
230000035764 nutrition Effects 0.000 claims description 5
210000003699 striated muscle Anatomy 0.000 claims description 5
FVVCFHXLWDDRHG-UPLOTWCNSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 FVVCFHXLWDDRHG-UPLOTWCNSA-N 0.000 claims description 4
241000196324 Embryophyta Species 0.000 claims description 4
102000010445 Lactoferrin Human genes 0.000 claims description 4
108010063045 Lactoferrin Proteins 0.000 claims description 4
235000021323 fish oil Nutrition 0.000 claims description 4
CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 4
229940078795 lactoferrin Drugs 0.000 claims description 4
235000021242 lactoferrin Nutrition 0.000 claims description 4
230000006609 metabolic stress Effects 0.000 claims description 4
230000035882 stress Effects 0.000 claims description 4
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 3
125000004032 5'-inosinyl group Chemical group 0.000 claims description 3
241000256844 Apis mellifera Species 0.000 claims description 3
239000004475 Arginine Substances 0.000 claims description 3
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 3
241000228212 Aspergillus Species 0.000 claims description 3
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims description 3
241000726108 Blastocystis Species 0.000 claims description 3
241000588807 Bordetella Species 0.000 claims description 3
241000193403 Clostridium Species 0.000 claims description 3
241000235035 Debaryomyces Species 0.000 claims description 3
241001136487 Eurotium Species 0.000 claims description 3
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 3
239000004471 Glycine Substances 0.000 claims description 3
244000068988 Glycine max Species 0.000 claims description 3
235000010469 Glycine max Nutrition 0.000 claims description 3
229930010555 Inosine Natural products 0.000 claims description 3
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 3
229920001202 Inulin Polymers 0.000 claims description 3
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 3
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 3
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 3
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 3
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 3
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 3
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 3
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 3
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 3
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 3
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 3
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 3
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 3
239000004472 Lysine Substances 0.000 claims description 3
241001468189 Melissococcus Species 0.000 claims description 3
IATUGZHPADVZPS-UHFFFAOYSA-N N1=CN=CC=C1.P(=O)(OCCC(=C)C)(O)O Chemical compound N1=CN=CC=C1.P(=O)(OCCC(=C)C)(O)O IATUGZHPADVZPS-UHFFFAOYSA-N 0.000 claims description 3
241000202223 Oenococcus Species 0.000 claims description 3
229910019142 PO4 Inorganic materials 0.000 claims description 3
241000191992 Peptostreptococcus Species 0.000 claims description 3
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 3
229920000294 Resistant starch Polymers 0.000 claims description 3
241000235070 Saccharomyces Species 0.000 claims description 3
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 3
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 3
239000004473 Threonine Substances 0.000 claims description 3
102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 3
108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 3
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 3
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 3
241000202221 Weissella Species 0.000 claims description 3
235000010489 acacia gum Nutrition 0.000 claims description 3
239000001785 acacia senegal l. willd gum Substances 0.000 claims description 3
235000004279 alanine Nutrition 0.000 claims description 3
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
235000009582 asparagine Nutrition 0.000 claims description 3
229960001230 asparagine Drugs 0.000 claims description 3
235000003704 aspartic acid Nutrition 0.000 claims description 3
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims description 3
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 3
230000015572 biosynthetic process Effects 0.000 claims description 3
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 3
235000018417 cysteine Nutrition 0.000 claims description 3
HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 3
235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 3
150000003271 galactooligosaccharides Chemical class 0.000 claims description 3
210000000232 gallbladder Anatomy 0.000 claims description 3
230000007661 gastrointestinal function Effects 0.000 claims description 3
235000013922 glutamic acid Nutrition 0.000 claims description 3
239000004220 glutamic acid Substances 0.000 claims description 3
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 3
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 3
229960003786 inosine Drugs 0.000 claims description 3
JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 3
229940029339 inulin Drugs 0.000 claims description 3
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 3
229960000310 isoleucine Drugs 0.000 claims description 3
JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 claims description 3
229960000511 lactulose Drugs 0.000 claims description 3
PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 claims description 3
229930182817 methionine Natural products 0.000 claims description 3
150000002482 oligosaccharides Chemical class 0.000 claims description 3
229920001277 pectin Polymers 0.000 claims description 3
235000010987 pectin Nutrition 0.000 claims description 3
239000001814 pectin Substances 0.000 claims description 3
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
239000010452 phosphate Substances 0.000 claims description 3
KPYHRMNYOUGKKI-UHFFFAOYSA-N phosphoric acid;1h-pyrimidine-2,4-dione Chemical compound OP(O)(O)=O.O=C1C=CNC(=O)N1 KPYHRMNYOUGKKI-UHFFFAOYSA-N 0.000 claims description 3
235000021254 resistant starch Nutrition 0.000 claims description 3
229920002477 rna polymer Polymers 0.000 claims description 3
150000005846 sugar alcohols Chemical class 0.000 claims description 3
229940104230 thymidine Drugs 0.000 claims description 3
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 3
239000004474 valine Substances 0.000 claims description 3
238000003304 gavage Methods 0.000 claims description 2
238000005457 optimization Methods 0.000 claims 1
238000010189 synthetic method Methods 0.000 claims 1
210000004027 cell Anatomy 0.000 description 16
230000008901 benefit Effects 0.000 description 11
241001465754 Metazoa Species 0.000 description 8
CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 6
230000000694 effects Effects 0.000 description 6
210000002784 stomach Anatomy 0.000 description 6
ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 5
ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 5
230000006870 function Effects 0.000 description 5
RQFCJASXJCIDSX-UHFFFAOYSA-N 14C-Guanosin-5'-monophosphat Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(COP(O)(O)=O)C(O)C1O RQFCJASXJCIDSX-UHFFFAOYSA-N 0.000 description 4
108010032088 Calpain Proteins 0.000 description 4
102000007590 Calpain Human genes 0.000 description 4
201000010099 disease Diseases 0.000 description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
230000036541 health Effects 0.000 description 4
230000006872 improvement Effects 0.000 description 4
238000012423 maintenance Methods 0.000 description 4
244000005700 microbiome Species 0.000 description 4
239000000178 monomer Substances 0.000 description 4
230000004899 motility Effects 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
230000008569 process Effects 0.000 description 4
108090000765 processed proteins & peptides Proteins 0.000 description 4
230000004844 protein turnover Effects 0.000 description 4
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
230000009102 absorption Effects 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
230000001195 anabolic effect Effects 0.000 description 3
229910001424 calcium ion Inorganic materials 0.000 description 3
239000000306 component Substances 0.000 description 3
229960003624 creatine Drugs 0.000 description 3
239000006046 creatine Substances 0.000 description 3
235000015872 dietary supplement Nutrition 0.000 description 3
238000009472 formulation Methods 0.000 description 3
210000000936 intestine Anatomy 0.000 description 3
230000000813 microbial effect Effects 0.000 description 3
239000000047 product Substances 0.000 description 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 description 2
AEOBEOJCBAYXBA-UHFFFAOYSA-N A2P5P Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1OP(O)(O)=O AEOBEOJCBAYXBA-UHFFFAOYSA-N 0.000 description 2
108010022579 ATP dependent 26S protease Proteins 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
GRSZFWQUAKGDAV-UHFFFAOYSA-N Inosinic acid Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-UHFFFAOYSA-N 0.000 description 2
244000241838 Lycium barbarum Species 0.000 description 2
235000015459 Lycium barbarum Nutrition 0.000 description 2
235000015468 Lycium chinense Nutrition 0.000 description 2
206010067994 Mucosal atrophy Diseases 0.000 description 2
DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 description 2
REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
102000044159 Ubiquitin Human genes 0.000 description 2
108090000848 Ubiquitin Proteins 0.000 description 2
DJJCXFVJDGTHFX-UHFFFAOYSA-N Uridinemonophosphate Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-UHFFFAOYSA-N 0.000 description 2
239000005862 Whey Substances 0.000 description 2
102000007544 Whey Proteins Human genes 0.000 description 2
108010046377 Whey Proteins Proteins 0.000 description 2
230000009471 action Effects 0.000 description 2
230000004888 barrier function Effects 0.000 description 2
ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
IERHLVCPSMICTF-UHFFFAOYSA-N cytidine monophosphate Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(COP(O)(O)=O)O1 IERHLVCPSMICTF-UHFFFAOYSA-N 0.000 description 2
230000006378 damage Effects 0.000 description 2
230000029087 digestion Effects 0.000 description 2
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
238000006073 displacement reaction Methods 0.000 description 2
235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
235000012041 food component Nutrition 0.000 description 2
239000005428 food component Substances 0.000 description 2
235000020510 functional beverage Nutrition 0.000 description 2
235000013376 functional food Nutrition 0.000 description 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
239000011785 micronutrient Substances 0.000 description 2
235000013369 micronutrients Nutrition 0.000 description 2
230000004220 muscle function Effects 0.000 description 2
239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
230000008439 repair process Effects 0.000 description 2
230000004044 response Effects 0.000 description 2
210000002027 skeletal muscle Anatomy 0.000 description 2
230000029663 wound healing Effects 0.000 description 2
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
102100035037 Calpastatin Human genes 0.000 description 1
ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
108010005843 Cysteine Proteases Proteins 0.000 description 1
102000005927 Cysteine Proteases Human genes 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
VHLJDTBGULNCGF-UHFFFAOYSA-N Limonin Natural products CC1(C)OC2CC(=O)OCC23C4CCC5(C)C(CC(=O)C6OC56C4(C)C(=O)CC13)c7cocc7 VHLJDTBGULNCGF-UHFFFAOYSA-N 0.000 description 1
244000241872 Lycium chinense Species 0.000 description 1
UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
241000736262 Microbiota Species 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
239000004365 Protease Substances 0.000 description 1
102000001253 Protein Kinase Human genes 0.000 description 1
ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
102100023152 Scinderin Human genes 0.000 description 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical class N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
230000001093 anti-cancer Effects 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000001857 anti-mycotic effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
239000002543 antimycotic Substances 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
108010044208 calpastatin Proteins 0.000 description 1
ZXJCOYBPXOBJMU-HSQGJUDPSA-N calpastatin peptide Ac 184-210 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C1=CC=C(O)C=C1 ZXJCOYBPXOBJMU-HSQGJUDPSA-N 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
235000021466 carotenoid Nutrition 0.000 description 1
150000001747 carotenoids Chemical class 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
235000017471 coenzyme Q10 Nutrition 0.000 description 1
235000012754 curcumin Nutrition 0.000 description 1
239000004148 curcumin Substances 0.000 description 1
229940109262 curcumin Drugs 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000000378 dietary effect Effects 0.000 description 1
VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
239000003814 drug Substances 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
229960005135 eicosapentaenoic acid Drugs 0.000 description 1
JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
238000009313 farming Methods 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
229930003935 flavonoid Natural products 0.000 description 1
150000002215 flavonoids Chemical class 0.000 description 1
235000017173 flavonoids Nutrition 0.000 description 1
235000013305 food Nutrition 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
239000003966 growth inhibitor Substances 0.000 description 1
230000007366 host health Effects 0.000 description 1
230000002519 immonomodulatory effect Effects 0.000 description 1
230000036737 immune function Effects 0.000 description 1
230000036039 immunity Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
210000001630 jejunum Anatomy 0.000 description 1
MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
KBDSLGBFQAGHBE-MSGMIQHVSA-N limonin Chemical compound C=1([C@H]2[C@]3(C)CC[C@H]4[C@@]([C@@]53O[C@@H]5C(=O)O2)(C)C(=O)C[C@@H]2[C@]34COC(=O)C[C@@H]3OC2(C)C)C=COC=1 KBDSLGBFQAGHBE-MSGMIQHVSA-N 0.000 description 1
235000012680 lutein Nutrition 0.000 description 1
229960005375 lutein Drugs 0.000 description 1
239000001656 lutein Substances 0.000 description 1
KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
235000012661 lycopene Nutrition 0.000 description 1
229960004999 lycopene Drugs 0.000 description 1
239000001751 lycopene Substances 0.000 description 1
OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
230000002132 lysosomal effect Effects 0.000 description 1
210000003712 lysosome Anatomy 0.000 description 1
230000001868 lysosomic effect Effects 0.000 description 1
108010011767 m-calpain Proteins 0.000 description 1
235000012054 meals Nutrition 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
230000000116 mitigating effect Effects 0.000 description 1
108010068164 mu-calpain Proteins 0.000 description 1
201000009240 nasopharyngitis Diseases 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
235000003715 nutritional status Nutrition 0.000 description 1
235000008935 nutritious Nutrition 0.000 description 1
210000003463 organelle Anatomy 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
229950007002 phosphocreatine Drugs 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
150000008442 polyphenolic compounds Chemical class 0.000 description 1
235000013824 polyphenols Nutrition 0.000 description 1
239000006041 probiotic Substances 0.000 description 1
230000000529 probiotic effect Effects 0.000 description 1
235000018291 probiotics Nutrition 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
108060006633 protein kinase Proteins 0.000 description 1
235000005875 quercetin Nutrition 0.000 description 1
229960001285 quercetin Drugs 0.000 description 1
108010073419 scinderin Proteins 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
235000011649 selenium Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
235000019722 synbiotics Nutrition 0.000 description 1
230000008685 targeting Effects 0.000 description 1
ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
230000001228 trophic effect Effects 0.000 description 1
230000007306 turnover Effects 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/13—Nucleic acids or derivatives thereof
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Mycology (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pediatric Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CN2010800405864A 2009-08-13 2010-08-09 包含外源性核苷酸的营养组合物 Pending CN102481009A (zh)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US23379609P	2009-08-13	2009-08-13
US61/233,796		2009-08-13
US23770909P	2009-08-28	2009-08-28
US61/237,709		2009-08-28
PCT/US2010/044852 WO2011019641A2 (fr)	2009-08-13	2010-08-09	Compositions nutritionnelles comprenant des nucléotides exogènes

Publications (1)

Publication Number	Publication Date
CN102481009A true CN102481009A (zh)	2012-05-30

Family

ID=43430621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN2010800405864A Pending CN102481009A (zh)	2009-08-13	2010-08-09	包含外源性核苷酸的营养组合物

Country Status (5)

Country	Link
US (1)	US20120189597A1 (fr)
EP (1)	EP2464246A2 (fr)
CN (1)	CN102481009A (fr)
CA (1)	CA2771283A1 (fr)
WO (1)	WO2011019641A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106721247A (zh) *	2016-11-10	2017-05-31	南京工业大学	一种可促进断奶猪仔肠道发育的饲料添加剂
CN108463124A (zh) *	2015-12-25	2018-08-28	大塚制药株式会社	凝胶样食品组合物
CN115997932A (zh) *	2021-10-22	2023-04-25	马斯公司	用作食物组合物的核苷酸和低聚糖
WO2024067345A1 (fr) *	2022-09-26	2024-04-04	黑龙江飞鹤乳业有限公司	Utilisation d'un nucléotide, composition nutritionnelle, produit alimentaire et utilisation correspondante

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2014510530A (ja) *	2011-03-31	2014-05-01	ネステクソシエテアノニム	アルギニンレベルを増加させる栄養組成物及びその使用方法
EP2699113A1 (fr) *	2011-04-18	2014-02-26	Nestec S.A.	Compositions nutritionnelles comprenant de l'alpha-hica et de l'acide eicosapentaénoïque
WO2015084158A1 (fr)	2013-12-06	2015-06-11	N.V. Nutricia	Dérivé de pyrimidine et source d'acides gras destinés à être utilisés pour traiter la constipation
MA52154B1 (fr)	2018-03-09	2022-09-30	Frimline Private Ltd	Composition pharmaceutique pour l'anémie

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4758553A (en) *	1983-12-09	1988-07-19	Otsuka Pharmaceutical Factory, Inc.	Compositions of nucletic acid components for nutritional replenishment
WO2009070378A1 (fr) *	2007-11-26	2009-06-04	Nestec S.A.	Compositions et procédés pour inhiber l'activation de la protéine kinase dépendante de l'arn à double brin et inhibition de la croissance de tumeur

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES507187A0 (es) *	1981-11-16	1983-01-01	Union Ind Y Agro Ganader S A U	Procedimiento de obtencion de una leche humanizada adiciona-da de nucleotidos con destino a la alimentacion infantil.
FR2543158B1 (fr) *	1983-03-24	1985-11-15	Inst Nat Sante Rech Med	Milieu de culture de cellules animales sans serum, sans hormones et sans facteurs de croissance et procedes de culture primaire et d'obtention de lignees cellulaires utilisant ce milieu
ES2007350A6 (es) *	1987-05-29	1989-06-16	Ganadera Union Ind Agro	Productos alimenticios enriquecidos con nucleosidos yno nucleotidos para la nutricion infantil y de adultos, y procedimiento para su preparacion.
US5780039A (en) *	1992-04-23	1998-07-14	Novartis Nutrition Ag	Orally-ingestible nutrition compositions having improved palatability
US6342484B1 (en) *	1993-06-30	2002-01-29	Board Of Regents, The University Of Texas Systems	Method and compositions for promotion of wound treatment
GB2381451A (en) *	2001-11-01	2003-05-07	New Technology Res Ltd	Pharmaco-dietary preparation having nutrition-supplementing and nutrition-enhancing effect
EP1776877A1 (fr) *	2005-10-21	2007-04-25	N.V. Nutricia	Méthode de stimulation de la flore intestinale
EP2679223A1 (fr) *	2006-04-04	2014-01-01	Nestec S.A.	Traitements utilisant de la citrulline
WO2009002146A1 (fr) *	2007-06-26	2008-12-31	N.V. Nutricia	Procédé pour supporter des activités de la vie quotidienne
DK2190304T3 (da) *	2007-09-17	2012-03-12	Nutricia Nv	Ernæringsformulering med højt energiindhold
CN102164595A (zh) *	2008-09-19	2011-08-24	雀巢产品技术援助有限公司	抗癌治疗中的免疫***营养支持

2010
- 2010-08-09 CN CN2010800405864A patent/CN102481009A/zh active Pending
- 2010-08-09 CA CA2771283A patent/CA2771283A1/fr not_active Abandoned
- 2010-08-09 EP EP10747342A patent/EP2464246A2/fr not_active Withdrawn
- 2010-08-09 WO PCT/US2010/044852 patent/WO2011019641A2/fr active Application Filing
- 2010-08-09 US US13/390,175 patent/US20120189597A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4758553A (en) *	1983-12-09	1988-07-19	Otsuka Pharmaceutical Factory, Inc.	Compositions of nucletic acid components for nutritional replenishment
WO2009070378A1 (fr) *	2007-11-26	2009-06-04	Nestec S.A.	Compositions et procédés pour inhiber l'activation de la protéine kinase dépendante de l'arn à double brin et inhibition de la croissance de tumeur

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘建文等: "外源核苷酸营养", 《动物科学与动物医学》, vol. 18, no. 6, 30 November 2001 (2001-11-30), pages 48 - 51 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108463124A (zh) *	2015-12-25	2018-08-28	大塚制药株式会社	凝胶样食品组合物
US11412770B2 (en)	2015-12-25	2022-08-16	Otsuka Pharmaceutical Co., Ltd.	Gel-like food composition
CN106721247A (zh) *	2016-11-10	2017-05-31	南京工业大学	一种可促进断奶猪仔肠道发育的饲料添加剂
CN111513204A (zh) *	2016-11-10	2020-08-11	南京工业大学	一种饲料添加剂在促进断奶猪仔肠道发育中的应用
CN111513204B (zh) *	2016-11-10	2023-07-18	南京工业大学	一种饲料添加剂在促进断奶猪仔肠道发育中的应用
CN115997932A (zh) *	2021-10-22	2023-04-25	马斯公司	用作食物组合物的核苷酸和低聚糖
WO2024067345A1 (fr) *	2022-09-26	2024-04-04	黑龙江飞鹤乳业有限公司	Utilisation d'un nucléotide, composition nutritionnelle, produit alimentaire et utilisation correspondante

Also Published As

Publication number	Publication date
US20120189597A1 (en)	2012-07-26
EP2464246A2 (fr)	2012-06-20
WO2011019641A3 (fr)	2011-04-07
WO2011019641A2 (fr)	2011-02-17
CA2771283A1 (fr)	2011-02-17

Legal Events

Date	Code	Title	Description
2012-05-30	C06	Publication
2012-05-30	PB01	Publication
2012-09-19	C10	Entry into substantive examination
2012-09-19	SE01	Entry into force of request for substantive examination
2014-08-27	C02	Deemed withdrawal of patent application after publication (patent law 2001)
2014-08-27	WD01	Invention patent application deemed withdrawn after publication	Application publication date: 20120530

Publication	Publication Date	Title
CN102481009A (zh)	2012-05-30	包含外源性核苷酸的营养组合物
JP6852980B2 (ja)	2021-04-14	低カロリー高タンパク質の栄養組成物及び該栄養組成物を用いる方法
US6544547B2 (en)	2003-04-08	Nutritional composition containing methionine
CN103476274A (zh)	2013-12-25	具有α-HICA和α-酮戊二酸的营养组合物
US8715742B2 (en)	2014-05-06	Method for reducing weight in a subject
ES2708771T3 (es)	2019-04-11	Formulaciones nutricionales que usan oligosacáridos de leche humana para modular la inflamación
RU2422049C2 (ru)	2011-06-27	Жидкая композиция, основанная на компоненте гуанидинуксусной кислоты
CN103025178B (zh)	2015-02-11	用于从胃肠外营养转换至肠内营养的营养组合物和方法
CN100469361C (zh)	2009-03-18	治疗或预防哺乳动物遭受代谢作用压力时的分解代谢或刺激性合成代谢的方法及组合物
EP2945494B1 (fr)	2017-03-08	Composition d'aliment pour bébés comprenant des bactéries viables produisant de l'acide propionique et des bacteries viables produisant de l'acide lactique
US20100124587A1 (en)	2010-05-20	Creatine-containing vitamin and mineral composition
US20080274127A1 (en)	2008-11-06	Amino acid supplementation for a healthy microbiota ecosystem
JP2013514812A (ja)	2013-05-02	栄養組成物及び食事の酸−塩基のポテンシャルを最適化するための方法
WO2013170189A1 (fr)	2013-11-14	Combinaison de bêta-hydroxy-bêta-méthylbutyrate et de bêta-alanine destinée à augmenter le débit musculaire
CN102595936A (zh)	2012-07-18	包含茶氨酸和外源性核苷酸的营养组合物
CN1048400C (zh)	2000-01-19	维生素微量元素嘌呤嘧啶双核苷酸营养素产品及制造方法
CN101277617A (zh)	2008-10-01	治疗肌肉萎缩的含甜菜碱的营养品
Kahraman et al.	2015	Folic acid in ruminant nutrition.
Soltwedel et al.	2003	Threonine is more limiting than valine in diets of lactation sows with high rates of body protein loss
UA53011U (uk)	2010-09-27	Функціональний харчовий продукт для різних верств населення