CN102451126B - Hair-growing cosmetic composition, and preparation method thereof - Google Patents
Hair-growing cosmetic composition, and preparation method thereof Download PDFInfo
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- CN102451126B CN102451126B CN 201010522342 CN201010522342A CN102451126B CN 102451126 B CN102451126 B CN 102451126B CN 201010522342 CN201010522342 CN 201010522342 CN 201010522342 A CN201010522342 A CN 201010522342A CN 102451126 B CN102451126 B CN 102451126B
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Abstract
The invention discloses a hair-growing cosmetic composition. An extraction solution containing the hair-growing cosmetic composition can be obtained by extracting plant which comprises acorus gramineus, spirulina powder, vitamin B5 and one of Chinese herbal medicines by using a small amount of an organic solution, and then performing solid-liquid separation and pelletizing. By a preparation method for the hair-growing cosmetic composition, the process can effectively simplified and the using of organic solvent can be reduced, and the obtained hair-growing cosmetic composition can promote hair to be blackened and grown and capillus to be increased, and the thick flavor of the Chinese herbal medicines can be saved or reduced greatly.
Description
Technical field
The invention relates to a kind of vegetalization cosmetic compositions and manufacture method thereof, particularly send out cosmetic composition and manufacture method thereof relevant for a kind of educating.
Background technology
The Chinese herbal medicine extract is widely used in natural drug (phyto-medicine), replenishes in alternative medicine therapy (alternative medicine), dietary supplement (dietary supplement), the function cosmetics (cosmaceuticals).The Chinese herbal medicine application mode, also by traditional directly take, coating, decoction, the red ball of cream are loose etc., along with the progress of science and technology, utilize different extraction modes, can further define and understand the contained active ingredient of Chinese herbal medicine.
Chinese herbal medicine extraction mode can generally be divided into the extraction of liquid phase-liquid phase or the extraction of solid phase-liquid phase, and wherein the extraction of solid phase-liquid phase also is called " leaching ", is the composition that utilizes in the various separated from solvent solid mixtures.
The Chinese herbal medicine extract can be according to different purposes or demand, and utilizes different modes to extract.Generally can utilize such as steam distillation method, fat and inhale (oils and fats separation) method, solvent extraction, cold press method, supercritical fluid carbon dioxide extraction, deep fat infusion method, resin extraction, vacuum distillation method etc., the different components of extraction Chinese herbal medicine.
Although Chinese herbal medicine contains many active ingredients, the flavour of a drug of Chinese herbal medicine are thick and heavy, educate when sending out product being applied to, and its thick and heavy taste of Chinese medicine is not easy to be accepted by most people.Secondly, when using known extraction Chinese herbal medicine, can consume a large amount of water or organic solvent, treatment step is also comparatively loaded down with trivial details simultaneously.
In view of this, needing badly provides a kind of educating to send out cosmetic composition and a manufacture method thereof, overcoming the thick and heavy problem of taste of Chinese medicine, and reduces the consumption of water or organic solvent.
The utility model content
One embodiment of the present invention is that a kind of manufacture method of sending out cosmetic composition of educating is being provided; it utilizes a small amount of organic extractant solution one vegetable matter; wherein this vegetable matter can be comprised of Rhizoma Acori Graminei (Acorus gramineus), spirulina (Spirulina sp.) powder, vitamin B5 and Chinese medicinal herbs; it can obtain to contain the extract of educating a cosmetic composition after solid-liquid filtration and micronize processing.This educates the use that manufacture method of sending out cosmetic composition can effectively be simplified processing procedure and reduce organic solvent, and gained educate send out a cosmetic composition can promote color development increase black, capillus increases, hair is grown up again without or significantly reduce thick and heavy taste of Chinese medicine.
Secondly, another embodiment of the present invention is to provide a kind of educating to send out cosmetic composition, it is to utilize said method extraction vegetable matter and get, can promote color development increase black, capillus increases, hair is grown up and without or significantly reduce thick and heavy taste of Chinese medicine, can use and being added into a relevant product of educating.
According to above-mentioned embodiment of the present invention, propose a kind of Chinese herbal medicine and educate the manufacture method of sending out cosmetic composition.In one embodiment, at first carry out an extraction step, it ties up in the reactive tank, with 0 ℃ to 50 ℃ temperature, utilizes an organic extractant solution one vegetable matter 2 hours to 72 hours.
In the above-described embodiments, aforesaid reactive tank for example can be an agitator tank, and this agitator tank system is with for example 20 to 50 ℃ temperature, by aforesaid organic extractant solution vegetable matter 2 hours to 72 hours.
In other embodiments, the previous reaction groove for example can be a Supersonic wave trough, and this Supersonic wave trough can utilize for example frequency of 30kHz to 70kHz, by aforesaid organic extractant solution vegetable matter 2 hours to 4 hours.In this embodiment, aforesaid Supersonic wave trough more can have a circulating cooling system, makes the temperature of this Supersonic wave trough when carrying out extraction step maintain for example 0 ℃ to 30 ℃.
When carrying out extraction step, the w/v of aforesaid vegetable matter and organic solution for example can be 0.1g/mL to 0.3g/mL.In another illustration, aforesaid organic solution for example can be ethanol and the water of volume ratio 1:4 to 3:2.In another illustration, aforesaid vegetable matter is comprised of the Rhizoma Acori Graminei (Acorus gramineus) of 2 percentage by weight to 4 percentage by weights, spirulina (Spirulina sp.) powder of 3 percentage by weight to 5 percentage by weights, the vitamin B5 of 0.5 percentage by weight to 2 percentage by weight and the Chinese medicinal herbs of 89 percentage by weight to 94.5 percentage by weights.In another illustration again, aforesaid Chinese medicinal herbs is by Semen Ginkgo (Ginkgo biloba) leaf, Semen Cuscutae (Cuscuta australis R.Brown or Cucsuta obtusiflora Kunth var.australis Engelm.), Radix Angelicae Sinensis (Angelicae Sinensis Radix), Cortex Moutan (root cortex of Paenoina suffruticos), Radix Rehmanniae Preparata (Rehmanniae Preparata Radix), Fructus Psoraleae (Psoraleae semen), Radix Polygoni Multiflori (Polygonum multiflorun, Dioscorea bulbifera, or Cynanchum wilfordi), the Radix Paeoniae Alba (Paeonia lactiflora), Rhizoma Polygonati (rhizome of Polygonatum kingianum Coll.Ex Hemsl., Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua), Fructus Schisandrae Chinensis (Schisandrae Fructus), Cortex Lycii (Lycii Radicis Cortex), Radix Ginseng (Ginseng Radix), Fructus Corni (Cornus officinalis), Rhizoma Zingiberis Recens (Zingiberis Rhizoma), Fructus Ligustri Lucidi (Ligustrum Lucidum), Cortex Cinnamomi (Cinnamomi Cortex), Semen Sesami Nigrum (Sesamun indicium Linn.), Radix Salviae Miltiorrhizae (Salvia multiorrhizae Bunge), Cacumen Platycladi (Platycladus orientalis (L.) Franco) leaf, Rhizoma Chuanxiong (Ligusticum Rhizoma), Rhizoma Drynariae (Drynariae Rhizoma), Radix Astragali (Astragali Radix), Fructus Mori (Mori Fructus), Fructus Rubi (Rubi Fructus), Radix Polygalae (Polygalae Radix), Semen sojae atricolor (Glycine max (L.) Merrill), Radix Aconiti Lateralis Preparata (Radix aconiti lateralis preparata) forms.Aforementioned organic solution is the mixed solution of ethanol and water, and this ethanol is ethanol or the Radix Betae ethanol of dehydrated alcohol, 95 percents by volume, and the volume ratio of this ethanol and water is 1:4 to 3:2.
Then, carry out solid-liquid separation step, to obtain a filtrate by the aforementioned organic solution that contains vegetable matter.
Then, carry out the micronize step, to obtain an extract by aforementioned filtrate.In an illustration, can utilize methods such as ball mill pulverizing method, pneumatic type injection comminuting method or high pressure homogenizing to carry out, with the above-mentioned filtrate of micronize.In another illustration; through micronize and the median particle diameter (D50) of extract for example can be 500nm to 1000nm; wherein this extract is that aforesaid educating sent out a cosmetic composition, and educating of gained sent out a cosmetic composition and be there is no or significantly reduce taste of Chinese medicine.
In an embodiment of the present invention, when carrying out aforementioned extraction step, more can add bittern water in the aforementioned organic solution that contains vegetable matter.
According to other embodiment of the present invention, propose a kind of educating and send out a cosmetic composition, it is characterized in that this educates to send out a cosmetic combinations system and utilize above-mentioned either method obtained.
Use of the present invention educating and send out cosmetic composition and manufacture method thereof; it is to utilize a small amount of organic extractant solution one vegetable matter; wherein this vegetable matter is comprised of for example Rhizoma Acori Graminei, Spirulina powder, vitamin B5 and Chinese medicinal herbs; after solid-liquid separation and micronize processing, can obtain to contain the extract of educating a cosmetic composition again.This Chinese herbal medicine is educated the use that the manufacture method of sending out cosmetic composition can effectively be simplified processing procedure and reduce organic solvent, and the Chinese herbal medicine of gained educate send out a cosmetic composition can promote color development increase black, capillus increases, hair is grown up again without or significantly reduce thick and heavy taste of Chinese medicine.
Description of drawings
For above and other objects of the present invention, feature, advantage and embodiment can be become apparent, appended graphic being described in detail as follows:
Educate according to an embodiment of the invention the manufacturing flow chart of sending out cosmetic composition shown in Fig. 1.
Fig. 2 educates the HPLC comparison collection of illustrative plates of sending out cosmetic composition according to an embodiment of the invention for showing.
Fig. 3 shows the HPLC comparison collection of illustrative plates of educating according to an embodiment of the invention each composition part of sending out cosmetic composition.
Fig. 4 illustrates to educate according to another embodiment of the present invention the HPLC comparison collection of illustrative plates of sending out cosmetic composition.
[primary clustering symbol description]
100: method
101: extract processing procedure, to utilize the step of organic extractant solution vegetable matter
103: carry out solid-liquid separation step, to be obtained the step of filtrate by the organic solution that contains vegetable matter
105: the above-mentioned filtrate of micronize, to obtain extract by filtrate, wherein extract can be and educates the step of sending out cosmetic composition
201/203/205/301/303/305/307/309/311/313/315/317/319/321/ 323/325/327/329/331/333/335/337/339/341/343/345/347/349/ 351/353/355/357/401/403: curve
The specific embodiment
Brought forward is described, the invention provides a kind of Chinese herbal medicine and educates cosmetic composition and a manufacture method thereof, and it is to utilize a small amount of organic extractant solution one vegetable matter.
The present invention herein alleged " educate and send out a cosmetic composition " means that the source is take vegetable matters such as Chinese medicinal herbses as main; the extract of processing gained through extraction, solid-liquid filtration and micronize contains to educate sends out a cosmetic composition, can promote color development to increase black, capillus increase, hair growth etc. and educate hair.
In one embodiment, this vegetable matter is by Rhizoma Acori Graminei (Acorus gramineus), spirulina (Spirulina sp.) powder, vitamin B5 and at least one Chinese medicinal herbs.In an illustration, aforesaid vegetable matter can comprise that the Rhizoma Acori Graminei of 2 percentage by weight to 4 percentage by weights, the Spirulina powder of 3 percentage by weight to 5 percentage by weights, the vitamin B5 of 0.5 percentage by weight to 2 percentage by weight and the Chinese medicinal herbs of 89 percentage by weight to 94.5 percentage by weights form.In another illustration, aforesaid Chinese medicinal herbs is by Semen Ginkgo (Ginkgo biloba) leaf, Semen Cuscutae (Cuscuta australis R.Brown or Cucsuta obtusiflora Kunth var.australis Engelm.), Radix Angelicae Sinensis (Angelicae Sinensis Radix), Cortex Moutan (root cortex of Paenoina suffruticos), Radix Rehmanniae Preparata (Rehmanniae Preparata Radix), Fructus Psoraleae (Psoraleae semen), Radix Polygoni Multiflori (Polygonum multiflorun, Dioscorea bulbifera, or Cynanchum wilfordi), the Radix Paeoniae Alba (Paeonia lactiflora), Rhizoma Polygonati (rhizome of Polygonatum kingianum Coll.Ex Hemsl., Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua), Fructus Schisandrae Chinensis (Schisandrae Fructus), Cortex Lycii (Lycii Radicis Cortex), Radix Ginseng (Ginseng Radix), Fructus Corni (Cornus officinalis), Rhizoma Zingiberis Recens (Zingiberis Rhizoma), Fructus Ligustri Lucidi (Ligustrum Lucidum), Cortex Cinnamomi (Cinnamomi Cortex), Semen Sesami Nigrum (Sesamun indicium Linn.), Radix Salviae Miltiorrhizae (Salvia multiorrhizae Bunge), Cacumen Platycladi (Platycladus orientalis (L.) Franco) leaf, Rhizoma Chuanxiong (Ligusticum Rhizoma), Rhizoma Drynariae (Drynariae Rhizoma), Radix Astragali (Astragali Radix), Fructus Mori (Mori Fructus), Fructus Rubi (Rubi Fructus), Radix Polygalae (Polygalae Radix), Semen sojae atricolor (Glycine max (L.) Merrill), Radix Aconiti Lateralis Preparata (Radix aconiti lateralis preparata) forms.
In addition, the present invention herein alleged " Spirulina powder " can comprise and utilizes any type of frond of conventional process gained or algae powder, for example the frond of fresh frond, drying, cryodesiccated frond, above-mentioned algae powder or other known any type of frond or algae powder through grinding.
Of the present invention educating sent out the above-mentioned vegetable matter of a small amount of organic extractant solution of cosmetic combinations system utilization and got.See also Fig. 1, it is to illustrate to educate according to an embodiment of the invention the manufacturing flow chart of sending out cosmetic composition.Furthermore, in one embodiment, this educates the manufacture method 100 of sending out cosmetic composition can carry out first an extraction step, it ties up in the reactive tank, with about 0 ℃ to about 50 ℃ temperature, utilize an organic extractant solution one vegetable matter 2 hours to 72 hours, shown in step 101.In an illustration, the w/v of aforesaid vegetable matter and organic solution for example can be 0.1g/mL to 0.3g/mL.In another illustration, aforesaid organic solution for example can be ethanol and the water of volume ratio 1:4 to 3:2.In another illustration, aforesaid organic solution for example can be ethanol and the water of volume ratio 1:1.In another illustration again, aforesaid ethanol can include but not limited to ethanol (for example medicinal alcohol of 95% (v/v)) or the Radix Betae ethanol (beet alcohol) of dehydrated alcohol, 95 percents by volume.In another illustration again, when carrying out aforementioned extraction step, more can add bittern water in the aforementioned organic solution that contains vegetable matter.
In the above-described embodiments, aforesaid reactive tank for example can be an agitator tank, in for example about 20 to about 50 ℃ temperature, by aforesaid organic extractant solution (following also can be described as leaching) vegetable matter 2 hours to 72 hours.In other embodiments, the previous reaction groove for example can be a Supersonic wave trough, and this Supersonic wave trough can utilize for example frequency of 30kHz to 70kHz, by aforesaid organic solution leaching vegetable matter 2 hours to 4 hours.In this embodiment, aforesaid Supersonic wave trough more can have a circulating cooling system, make the temperature of this Supersonic wave trough when carrying out extraction step maintain for example about 0 ℃ to about 30 ℃, the heat loss that is produced when reducing because of the operation ultrasound, and can avoid the volatilization of low-boiling point material and the inactivation of bioactive substance.
Then, carry out solid-liquid separation step, to obtain a filtrate by the aforementioned organic solution that contains vegetable matter, wherein this filtrate can comprise an aforesaid cosmetic composition of educating, shown in step 103, drive the method for capable solid-liquid separation in the thought into, can utilize such as known filter membrane (filter material), diatomite filtration method, the mode such as centrifugal and carry out, this should be the technical staff in the technical field of the invention knows, so do not give unnecessary details in addition.
Then, the above-mentioned filtrate of micronize, shown in step 105, to obtain an extract by aforementioned filtrate, wherein this extract is sent out cosmetic composition for educating.In an illustration, can utilize methods such as ball milling or high pressure homogenizing, the above-mentioned filtrate of micronize.In another illustration, through micronize and the median particle diameter (D50) of extract for example can be 500nm to 1000nm.
It is worth mentioning that; utilize aforementioned vegetable matter with special formulation; after a small amount of organic extractant solution and micronize processing; not only effectively simplify processing procedure and reduce the use of organic solvent; can effectively remove again or significantly reduce and educate the thick and heavy taste of Chinese medicine of sending out cosmetic composition, send out a product so can be applicable to relevant educating.For example, the extract of above-mentioned gained can be separately sent out a product as educating, and perhaps extract is added directly to existing educating and sends out in the product as active component, or extract is added into existing educating after drying again to be sent out in the product as active component.
The present invention herein alleged " educate and send out a product " mean add above-mentioned educate send out cosmetic composition as active component after, can separately or make an addition to other known educating and send out in the product, with promote color development increase black, capillus increases, the hair growth.Of the present invention educating sent out cosmetic composition after trial volunteer uses 6 months to 12 months, prove to have to promote color development to increase function black, that capillus increases, hair is grown up, and nothing or significantly reduce thick and heavy taste of Chinese medicine.
Below utilize several embodiments so that application of the present invention to be described, so it is not to limit the present invention, the technical staff in the technical field of the invention, without departing from the spirit and scope of the present invention, when being used for a variety of modifications and variations.
Embodiment one: preparation Chinese herbal medicine hair-growing composition
Cosmetic composition is sent out relevant for utilizing the vegetable matter preparation to educate by this embodiment system.The vegetable matter system that this embodiment uses comprises the Rhizoma Acori Graminei of 2 percentage by weight to 4 percentage by weights, the Spirulina powder of 3 percentage by weight to 5 percentage by weights, the vitamin B5 of 0.5 percentage by weight to 2 percentage by weight and at least one Chinese medicinal herbs of 89 percentage by weight to 94.5 percentage by weights.Aforesaid at least one Chinese medicinal herbs can include but not limited to the group that Folium Ginkgo, Semen Cuscutae, Radix Angelicae Sinensis, Cortex Moutan, Radix Rehmanniae Preparata, Fructus Psoraleae, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Cortex Lycii, Radix Ginseng, Fructus Corni, Rhizoma Zingiberis Recens, Fructus Ligustri Lucidi, Cortex Cinnamomi, Semen Sesami Nigrum, Radix Salviae Miltiorrhizae, Cacumen Platycladi, Rhizoma Chuanxiong, Rhizoma Drynariae, Radix Astragali, Fructus Mori, Fructus Rubi, Radix Polygalae, Semen sojae atricolor, Radix Aconiti Lateralis Preparata or above-mentioned combination in any form.In another illustration, shown in aforesaid vegetable matter the 1st table:
The 1st table
Then, the vegetable matter of the 1st table is placed agitator tank, mixing plant (auspicious Thailand smart machine limited company, HD-550, Taiwan) for example is in for example about 20 to about 50 ℃ temperature, turn (revolution per minute with per minute about 2000; Rpm) to the rotating speed of about 3000rpm, by ethanol water (for example ethanol and the water of 95 percents by volume of volume ratio 1:1, ultimate density is the ethanol water of 47.5 percents by volume) extract vegetable matter 2 hours to 72 hours, wherein the vegetable matter of the 1st table and the w/v of ethanol water for example can be 0.1g/mL to 0.3g/mL.Perhaps, the 1st vegetable matter of showing is placed above-mentioned agitator tank, in for example about 45 ℃ temperature, the rotating speed of about 2500rpm, extract about 2 hours to 4 hours of vegetable matter by aforesaid ethanol water.
Another kind of mode, also the vegetable matter of the 1st table can be placed the Supersonic wave trough, ultrasound disintegrating apparatus (SONIC for example, VCX 750, U.S.A.), frequency with for example 30kHz to 70kHz, in for example about 0 ℃ to about 30 ℃ temperature, by Radix Betae ethanol water (for example Radix Betae ethanol and the water of volume ratio 1:1, ultimate density is the Radix Betae ethanol water of 50 percents by volume) extract vegetable matter 2 hours to 72 hours, wherein the vegetable matter of the 1st table and the w/v of Radix Betae ethanol water for example can be 0.1g/mL to 0.3g/mL.Perhaps, the vegetable matter of the 1st table is placed above-mentioned Supersonic wave trough, in for example about 45 ℃ temperature, extract about 2 hours to 4 hours of vegetable matter by aforesaid ethanol water, wherein the vegetable matter of the 1st table and the w/v of ethanol water for example can be 0.1g/mL to 0.3g/mL.After this extraction step was processed, its solid content for example can be 1 percentage by weight to 5 percentage by weight.
In another embodiment, when carrying out aforementioned extraction step, more can add bittern water in the aforementioned organic solution that contains vegetable matter.The present invention herein alleged " bittern water " means that utilizing brine gauge to record Baume degrees (° B é) reaches the salt that 29 degree are above, have bitterness.In an illustration, this bittern water for example can be 0.2% (m/m) to 0.5% (m/m) in the aforementioned addition that contains the organic solution of vegetable matter.In another illustration, this bittern water for example can be 0.3% (m/m) to 0.4% (m/m) in the aforementioned addition that contains the organic solution of vegetable matter.
Then, can utilize such as filter membrane (filter material), diatomite filtration method, the conventional approaches such as centrifugal, carry out solid-liquid separation step and obtain a filtrate.
Afterwards, carry out the micronize processing procedure, to obtain an extract by aforementioned filtrate.It can be to utilize ball mill pulverizing equipment, pneumatic type to spray disintegrating apparatus or high pressure homogenizing equipment, makes the further micronize of above-mentioned filtrate.Another kind of mode also can be utilized high pressure homogenizing equipment (for example APV-2000high pressure homogenizer, SPX Corp., U.S.A), makes the further micronize of above-mentioned filtrate.Through micronize and the median particle diameter (D50) of extract for example can be 500nm to 1000nm, wherein this extract can comprise that aforesaid educating send out a cosmetic composition, and this educates and sends out a cosmetic composition and there is no or significantly reduce thick and heavy taste of Chinese medicine.In utilizing the embodiment of Radix Betae ethanol water extraction, its typical mean solids content is about 3.39%, and measures and contain the polyphenol of the zingiberol of the 0.084mg/mL that has an appointment, about 1.57mg/mL and total candy of about 46mg/mL.
Be noted that because this embodiment utilizes the 1st table to have the vegetable matter of special formulation at this, process through a small amount of organic extractant solution and micronize, therefore can effectively remove or significantly reduce and educate the thick and heavy taste of Chinese medicine of sending out cosmetic composition.
See also Fig. 2, it is cosmetic composition is sent out in demonstration according to an embodiment of the invention through educating of agitator tank gained high efficiency liquid chromatography (LC) (High Performance Liquid Chromatography; HPLC) comparison collection of illustrative plates, wherein transverse axis be the time (minute), the longitudinal axis is trap (absorbance unit; A.U.), curve 201 is the HPLC analysis result of Cacumen Platycladi, curve 203 is for utilizing the HPLC analysis result of sending out cosmetic composition of educating of the 1st vegetable matter (the not containing Cacumen Platycladi) gained of showing, and curve 205 is for utilizing the HPLC analysis result of sending out cosmetic composition of educating of the 1st vegetable matter gained of showing.
See also Fig. 3, it is that the HPLC comparison collection of illustrative plates that each that send out cosmetic composition forms part is educated in demonstration according to an embodiment of the invention, wherein transverse axis be the time (minute), the longitudinal axis is trap (absorbance unit; A.U.), to show curve 301 (spirulina), curve 303 (Cortex Lycii), curve 305 (Radix Aconiti Lateralis Preparata), curve 307 (Radix Rehmanniae Preparata), curve 309 (Radix Astragali), curve 311 (Rhizoma Polygonati), curve 313 (Semen sojae atricolor), curve 315 (Fructus Corni), curve 317 (Fructus Ligustri Lucidi), curve 319 (Radix Ginseng), curve 321 (Rhizoma Zingiberis Recens), curve 323 (Fructus Rubi), curve 325 (Fructus Mori), curve 327 (Semen Sesami Nigrum), curve 329 (Fructus Psoraleaes; Psoralea corylifolia L.), curve 331 (Rhizoma Drynariae), curve 333 (Semen Cuscutae), curve 335 (Radix Polygalae), curve 337 (Rhizoma Acori Graminei), curve 339 (Rhizoma Chuanxiong), curve 341 (Radix Polygoni Multiflori), curve 343 (Radix Angelicae Sinensis), curve 345 (Cortex Cinnamomi), curve 347 (Fructus Schisandrae Chinensis), curve 349 (Radix Paeoniae Alba), curve 351 (Radix Salviae Miltiorrhizae), curve 353 (Cortex Moutan), curve 355 (Folium Ginkgo), the HPLC analysis result of curve 357 (educate and send out cosmetic composition).
By comparing as can be known of Fig. 2 and Fig. 3, each composition that cosmetic composition contains the listed vegetable matter of the 1st table is really sent out in educating of embodiment one gained, comprises spirulina, Cortex Lycii, Radix Aconiti Lateralis Preparata, Radix Rehmanniae Preparata, Radix Astragali, Rhizoma Polygonati, Semen sojae atricolor, Fructus Corni, Fructus Ligustri Lucidi, Radix Ginseng, Rhizoma Zingiberis Recens, Fructus Rubi, Fructus Mori, Semen Sesami Nigrum, Fructus Psoraleae, Rhizoma Drynariae, Semen Cuscutae, Radix Polygalae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Radix Polygoni Multiflori, Cacumen Platycladi, Radix Angelicae Sinensis, Cortex Cinnamomi, Fructus Schisandrae Chinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Moutan, Folium Ginkgo.
In this embodiment, more can utilize the HPLC system, for example diode arrays UV detector (Diode Array UV Detector, HITACHI, L-7455, Tokyo, Japan).The chromatography condition illustration is as follows: the chromatography tubing string for example can be COSMOSIL 5C18 MS-II tubing string (5 μ m, 4.6mm * 250mm) or the suitable person of other character.Mobile by 0.1% phosphoric acid (H
3PO
4Solvent orange 2 A) and second cyanogen (CH
3CN; Solvent B) forms (Fig. 4).In other illustration, the mobile of chromatography condition mutually also can be for by deionized water (solvent orange 2 A) and 80% second cyanogen (CH
3CN; Solvent B) forms.Solvent gradient program setting condition can be shown and following illustration such as the 2nd: flow velocity for example can be controlled in 1.0mL/min.The chromatography temperature can maintain 35 ℃.After containing the membrane filtration that the sample of educating the extract of sending out cosmetic composition can utilize 0.5m for example, carry out the analysis of HPLC finger printing, wherein inject HPLC systematic sample volume and for example can be 20 μ L, the internal standard product are propyl p-hydroxybenzoate (the propyl paraben of 250g/mL; PPB) solution.The wavelength of the UV spectrum of detecting for example can be 200nm to 380nm.
The 2nd table
See also Fig. 4, it is cosmetic composition is sent out in demonstration according to another embodiment of the present invention through educating of agitator tank gained HPLC finger printing (finger profile), wherein transverse axis be the time (minute), the longitudinal axis is trap (A.U.), curve 401 is the HPLC analysis result of the vegetable matter (raw material) of the 1st table, and curve 403 is for utilizing the 1st vegetable matter of showing through the HPLC analysis result of sending out cosmetic composition of educating of agitator tank gained.By the result of Fig. 4 as can be known, educating of embodiment one sent out cosmetic composition (curve 403) compared to raw material (curve 401), more have more peak value 6 (Radix Polygalae), peak value 8 (Radix Polygalae), peak value 16 (unknown new composition), peak value 17 (Folium Ginkgo), peak value 19 (unknown new composition), salvianolic acid B (salvianolic acid B), schizandrin (Schizandrin) etc., shown in curve 403.
In addition, in other embodiments, utilize the medicinal alcohol of 50% (v/v) or utilize the beet alcohol of 50% (v/v) to send out cosmetic composition through educating of Supersonic wave trough extraction, also can utilize respectively HPLC and through wavelength 254nm, 280nm, after the 366nm detecting, the HPLC finger printing of gained shows, utilize the medicinal alcohol of 50% (v/v) or utilize the educating of beet alcohol extraction gained of 50% (v/v) to send out cosmetic composition, both are utilizing wavelength 254nm, 280nm, HPLC finger printing after the 366nm detecting is analyzed, the distribution of its each peak value is identical (figure does not illustrate) all, does not give unnecessary details in addition at this.
Embodiment two: the test result of trial volunteer
This embodiment is the trial volunteer with 10, and educating of test implementation example one sent out cosmetic composition to the zest of skin and for educating the effect of sending out, and wherein has 5 experimenters to continue to use and reaches 12 months.
1. skin patch test (skin patch test)
Skin patch test (skin patch test) for be widely used at present, safety easy inspection technique again, it mainly is that the assessment test substance touches skin, whether cause various uncomfortable reactions, such as itch, red, sting, swell, peel, stop using etc., understand by this test substance to the zest of skin.
This embodiment is the trial volunteer with 5, utilizes skin patch test, and assessment contains educating of embodiment one and sends out cosmetic composition for the zest of scalp.The skin patch system of this embodiment is with 8 * 8 square millimeters of (mm
2) safe patch (the Finn chamber of area
, Epitest Ltd Oy, Finland), do not contain or immerse to contain to educate and send out cosmetic composition, about 48 hours of the scalp that again this skin patch is attached at the experimenter.Afterwards, take off the skin patch, and in 3 hours, observe and note down experimenter's scalp condition, as described in its result shows such as the 3rd.In addition, the experimenter uses in educating of embodiment one send out during 12 months of cosmetic composition, observe and note down and use rear scalp whether uncomfortable reaction is arranged, such as itch, red, sting, swell, peel, stop using etc., send out cosmetic composition for the adaptive impact of scalp with educating of assessment embodiment one.
The 3rd table
| Scalp condition | Skin patch test (X/Y) | Scalp adaptive testing (X/Y) |
| Itch | 0/5 | 0/5 |
| Red, thorn | 0/5 | 0/5 |
| Swollen | 0/5 | 0/5 |
| Decortication | 0/5 | 0/5 |
| Stop using | 0/5 | 0/5 |
(annotate: the X of the 3rd table represents to have the number of uncomfortable reaction, and Y represents to test total number of persons.)
By the result of the 3rd table as can be known, skin patch and contain the skin patch that educating of embodiment one sent out cosmetic composition is for scalp nonirritant all.
2. assessment is educated and is sent out effect
This embodiment system utilizes skin patch test with 10 trial volunteer, and assessment contains educating of embodiment one and sends out cosmetic composition for educating the effect of sending out, and wherein has 5 experimenters to continue to use and reaches 12 months, and its result is as described in the 5th table.
The relevant assessment that improves scalp (or hair) moisturizing degree, "+" means and is higher than more than 1.2 times of initial measurement, " 0 " means that "-" means 0.9 times that is lower than initial measurement without obviously changing.
The assessment that the sebum of relevant scalp is regulated, "+" means and suppresses experimenter's scalp lipid (being fit to oiliness scalp person), "-" means and promotes experimenter's scalp lipid (being not suitable for oiliness scalp person).
The assessment that the lipid of relevant hair improves, "+" means and is higher than more than 1.2 times of initial measurement, " 0 " means that "-" means 0.9 times that is lower than initial measurement without obviously changing.
The assessment of relevant scalp (or hair) pH-value, "+" means compared to the initial measurement pH value to be increased more than 0.2, and " 0 " means that "-" means and reduce more than 0.2 compared to initial measurement without obviously changing.
The assessment of relevant color development, the present invention system is with the variable quantity of δ-value gap 1.5, as color development difference measurement index.In specific words, the present invention herein alleged " δ-value " be that expression is according to (the Commission International Del ' Eclairage of International Commission on Illumination; CIE) method for expressing that proposes utilizes colorimeter measurement color development lightness (lighiness; L) variable quantity (L
2-L
1) after, the numerical value that calculates according to following formula (I):
Wherein, L
1For the experimenter use educating of embodiment one send out cosmetic composition before utilize the color development brightness value of colorimeter measurement, L
2For using educating of embodiment one, the experimenter sends out cosmetic composition utilizes colorimeter measurement after a period of time color development brightness value.Generally speaking, the aberration gap that δ-value represents can be listed such as the aberration hierarchical table of the 4th table, and the present invention system is with the variable quantity of δ-value gap 1.5, third level aberration namely, as color development difference measurement index:
The 4th table
The assessment of relevant hair growth rate, "+" means that every month, hair was grown up more than 0.2 centimeter (0.2cm/m), " 0 " means without obviously changing.
The 5th table
(annotate: the X of the 5th table represents to be improved the number of reaction, and Y represents to test total number of persons.)
By the result of the 5th table as can be known, utilize educating of embodiment one to send out a cosmetic composition, really can promote color development increase black, capillus increases, hair is grown up.
What need replenish is, though the present invention is take the Chinese herbal medicine of special formulation, specific extraction conditions, particular analysis method or particular instrument as illustration, cosmetic composition and the manufacture method thereof of educating of the present invention is described, but the technical staff in the technical field of the invention as can be known, the present invention is not limited to this, without departing from the spirit and scope of the present invention, of the present invention educating sent out cosmetic composition and manufacture method can use Chinese herbal medicine, other extraction conditions, other analytical method or the Other Instruments of other prescription to carry out.
By the invention described above embodiment as can be known; of the present invention educating sent out cosmetic composition and manufacture method thereof; its advantage is to utilize a small amount of organic extractant solution one vegetable matter; wherein this vegetable matter can be comprised of Rhizoma Acori Graminei, Spirulina powder, vitamin B5 and Chinese medicinal herbs; after solid-liquid filtration and micronize processing, can obtain to contain the extract of educating a cosmetic composition again.This educates the use that manufacture method of sending out cosmetic composition can effectively be simplified processing procedure and reduce organic solvent, and gained educate send out a cosmetic composition can promote color development increase black, capillus increases, hair is grown up again without or significantly reduce thick and heavy taste of Chinese medicine.
Although the present invention with several embodiment openly as above; so it is not to limit the present invention; the technical staff in the technical field of the invention; without departing from the spirit and scope of the present invention; when can being used for a variety of modifications and variations, so protection scope of the present invention is as the criterion when looking accompanying the claim person of defining.
Claims (9)
1. educate the manufacture method of sending out cosmetic composition for one kind, comprise at least:
Carry out an extraction step, it is in a reactive tank, temperature with 0 ℃ to 50 ℃, utilize an organic extractant solution one vegetable matter, wherein this vegetable matter is by the Rhizoma Acori Graminei of 2 percentage by weight to 4 percentage by weights, the Spirulina powder of 3 percentage by weight to 5 percentage by weights, 0.5 the Chinese medicinal herbs of the vitamin B5 of percentage by weight to 2 percentage by weight and 89 percentage by weight to 94.5 percentage by weights forms, described Chinese medicinal herbs is by Folium Ginkgo, Semen Cuscutae, Radix Angelicae Sinensis, Cortex Moutan, Radix Rehmanniae Preparata, Fructus Psoraleae, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Cortex Lycii, Radix Ginseng, Fructus Corni, Rhizoma Zingiberis Recens, Fructus Ligustri Lucidi, Cortex Cinnamomi, Semen Sesami Nigrum, Radix Salviae Miltiorrhizae, Cacumen Platycladi, Rhizoma Chuanxiong, Rhizoma Drynariae, Radix Astragali, Fructus Mori, Fructus Rubi, Radix Polygalae, Semen sojae atricolor, Radix Aconiti Lateralis Preparata forms, described organic solution is the mixed solution of ethanol and water, this ethanol is dehydrated alcohol, the ethanol of 95 percents by volume or Radix Betae ethanol, and the volume ratio of this ethanol and water is 1:4 to 3:2;
Carry out a solid-liquid separation step, to obtain a filtrate by this organic solution that contains this vegetable matter; And
Carry out a micronize step, to obtain an extract by this filtrate, wherein this extract is educated for this and is sent out a cosmetic composition, and this is educated and sends out a cosmetic composition and there is no or significantly reduce taste of Chinese medicine.
2. the manufacture method of sending out cosmetic composition of educating according to claim 1, wherein the time of this this vegetable matter of organic extractant solution is 2 hours to 72 hours, and the w/v of this vegetable matter and this organic solution is 0.1g/mL to 0.3g/mL.
3. the manufacture method of sending out cosmetic composition of educating according to claim 1, when carrying out this extraction step, more add bittern water in this vegetable matter and this organic solution, and this bittern water is that 0.2% (m/m) is to 0.5% (m/m) in the addition of this organic solution that contains this vegetable matter.
4. the manufacture method of sending out cosmetic composition of educating according to claim 1, wherein this reactive tank is an agitator tank, and this agitator tank system with 20 to 50 ℃ temperature by this vegetable matter of this organic extractant solution 2 hours to 72 hours.
5. the manufacture method of sending out cosmetic composition of educating according to claim 1, wherein this reactive tank is a Supersonic wave trough, and this Supersonic wave trough frequency of utilizing 30kHz to 70kHz was by this vegetable matter of this organic extractant solution 2 hours to 4 hours.
6. the manufacture method of sending out cosmetic composition of educating according to claim 5, wherein this Supersonic wave trough has more a circulating cooling system, makes the temperature of this Supersonic wave trough when carrying out this extraction step maintain 0 ℃ to 30 ℃.
7. the manufacture method of sending out cosmetic composition of educating according to claim 1, wherein this micronize step is for utilizing ball mill pulverizing method, pneumatic type injection comminuting method or high pressure homogenizing method to carry out.
8. the manufacture method of sending out cosmetic composition of educating according to claim 1, wherein a median particle diameter (D50) of this extract is 500nm to 1000nm.
9. educate a cosmetic composition for one kind, it is characterized in that this educates a cosmetic composition is that utilization is obtained such as the either method of claim 1 to 8.
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| CN103445997A (en) * | 2012-06-05 | 2013-12-18 | 中华全国供销合作总社南京野生植物综合利用研究院 | Formula and preparation method of natural plant anti-hair-loss and anti-dandruff shampoo |
| CN102727859B (en) * | 2012-07-19 | 2013-12-04 | 魏中玉 | Traditional Chinese medicine hair blackening composition, extracting solution thereof and traditional Chinese medicine hair blackening solution |
| CN103919888B (en) * | 2014-04-30 | 2016-04-06 | 杨理容 | A kind of compound hair oil and preparation method thereof |
| CN104491778A (en) * | 2014-12-05 | 2015-04-08 | 广东聚智诚科技有限公司 | Pharmaceutical composition for treating alopecia areata |
| CN105031145A (en) * | 2015-07-01 | 2015-11-11 | 路贝贝 | Hair-restoring and hair-nourishing traditional Chinese medicine composition |
| SG10201507607RA (en) * | 2015-09-14 | 2017-04-27 | Moleac Pte Ltd | Process For Producing Traditional Chinese Medicine Compositions, And Compositions Obtainable By The Process |
| CN105902455A (en) * | 2016-06-28 | 2016-08-31 | 龙梅奎 | Shampoo with function of promoting hair growth |
| CN106421356A (en) * | 2016-08-25 | 2017-02-22 | 李洪芳 | Medicine for treating hair loss and preparation method of medicine |
| CN107569665B (en) * | 2017-09-13 | 2020-12-22 | 高康日化集团有限公司 | Shampoo for preventing and treating alopecia |
| CN113730286A (en) * | 2020-05-29 | 2021-12-03 | 欣绿智国际企业有限公司 | Method for producing small molecule hair tonic and small molecule hair tonic |
| CN113768854A (en) * | 2021-10-29 | 2021-12-10 | 浙江章光101有限公司 | Traditional Chinese medicine composition for nourishing scalp and moistening hair and preparation method thereof |
| CN114848516A (en) * | 2022-05-13 | 2022-08-05 | 媞颂日化用品(广州)有限公司 | Anti-hair-loss and hair-protecting shower gel containing biotin tripeptide-1 for pets and preparation method thereof |
| CN115487245B (en) * | 2022-10-21 | 2023-06-06 | 陕西中医药大学 | Blood-nourishing hair-growing cream and preparation method thereof |
| CN116870071B (en) * | 2023-08-23 | 2024-04-05 | 广东药科大学 | Traditional Chinese medicine composition for eyebrow generation, eyebrow generation powder, and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1431006A (en) * | 2003-01-23 | 2003-07-23 | 郭建培 | Pilatory |
| CN1528261A (en) * | 2003-10-08 | 2004-09-15 | 张洪庭 | Shampoo for treating white hair and lipso trichia and eliminating toxicant and preparing method thereof |
| CN101152529A (en) * | 2007-10-17 | 2008-04-02 | 蔡威 | Externally used compound traditional Chinese medicine painting preparation for treating alopecia and method for preparing the same |
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| CN1431006A (en) * | 2003-01-23 | 2003-07-23 | 郭建培 | Pilatory |
| CN1528261A (en) * | 2003-10-08 | 2004-09-15 | 张洪庭 | Shampoo for treating white hair and lipso trichia and eliminating toxicant and preparing method thereof |
| CN101152529A (en) * | 2007-10-17 | 2008-04-02 | 蔡威 | Externally used compound traditional Chinese medicine painting preparation for treating alopecia and method for preparing the same |
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