CN102441089B - Traditional Chinese herbal composition for lumbar vertebra rheumatic pain and preparation method thereof - Google Patents
Traditional Chinese herbal composition for lumbar vertebra rheumatic pain and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese herbal composition for lumbar vertebra rheumatic pain and a preparation method thereof, wherein the traditional Chinese herbal composition is prepared from 19 kinds of traditional Chinese medicines of cassia twig, rhizoma homalomenae, cortex acanthopanacis, peach kernel, rhizoma drynariae, radix paeoniae rubra, ledebouriella seseloides wolff, radix angelicae pubescentis, rhizoma dioscoreae colletii, radix stephaniae tetrandrae, radix clematidis, processed radix aconiti kusnezoffii, parasitic loranthus, gentiana macrophylla, safflower carthamus, caulis piperis futokadsurae, radix angelicae, radix dipsaci and angelica sinensis; the composition has the effects of strengthening the bones and tendons, replenishing qi and blood, relaxing tendons, activating collaterals, dispelling wind, eliminating dampness, activating rheumatism and relieving the pain; and the composition is mainly used for treating sthenic syndrome backache, and has very good effect on lumbar vertebra rheumatic pain. The composition has obvious clinical pharmacodynamic study test, is safe and has no toxic side effect.
Description
Technical field
The present invention relates to a kind of lumbar vertebra arthralgia pain Chinese medicine composition and preparation method thereof, belong to the pharmaceutical technology field.
Technical background
The lumbar vertebra arthralgia pain is a kind of common lumbar disc disease, has brought great misery for people's life, and the Chang Fanfu outbreak, has seriously influenced the healthy of people.At present modern medicine to the treatment of this disease mainly based on anti-inflammatory agent, hormone, Chinese patent medicine, physical therapy, acupuncture, all can only relief of symptoms, what have also has serious toxic and side effects.The operative treatment risk is bigger, the expense height.Therefore, develop a kind of cure rate height, do not recur after healing, safety, the medicine that has no side effect seems very urgent.
" lumbar vertebra arthralgia pain treating bolus " is exactly a kind of Chinese patent medicine for the treatment of the lumbar vertebra arthralgia pain under the 16th WS3-B-3117-98 item of ministry standard " Chinese traditional patent formulation preparation ", the consumption of each medical material but it is not openly write out a prescription, and do not have preparation technology.The inventor is by excavating the abundant natural resources of Chinese medicinal materials of motherland, in conjunction with a large amount of traditional Chinese medical science prescription theories and clinical pharmacodynamic experiment, to have invented a kind of prescription and constituted clearly, technology is simple, evident in efficacy, dosage is a kind of Chinese medicine composition for the treatment of the lumbar vertebra arthralgia pain and preparation method thereof accurately.
Summary of the invention
The objective of the invention is to: a kind of lumbar vertebra arthralgia pain Chinese medicine composition evident in efficacy and preparation method thereof is provided.Be characterized in: the consumption proportion of each flavour of a drug of Chinese medicine composition of the present invention is:
52 parts in 52 parts of Semen Persicaes of 52 parts of Cortex Acanthopanciss of 52 parts of Rhizoma Homalomenaes of Ramulus Cinnamomi
52 parts of 52 parts of Radix Angelicae Pubescentiss of 78 parts of Radix Saposhnikoviaes of 26 parts of Radix Paeoniae Rubra of Rhizoma Drynariae
52 parts of 52 parts of Radix Aconiti Kusnezoffii Preparatas of 78 parts of Radix Clematidis of 26 parts of Radixs Stephaniae Tetrandrae of Rhizoma Dioscoreae Septemlobae
52 parts of 52 portions of Caulis Piperis Kadsuraes of 52 parts of Flos Carthamis of 26 portions of Radix Gentianae Macrophyllae of Herba Taxilli
26 parts of 52 parts of Radix Angelicae Sinensis of 78 parts of Radix Dipsacis of the Radix Angelicae Dahuricae.
Each flavour of a drug weight proportion of the present invention is to find through the pharmacological screening test of strictness: its clinical pharmacodynamics test effect is remarkable, and without any side effects.We routinely technology make pill, capsule, tablet and granule.
1, preparation method of the present invention is as follows:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 1-3 time, add water 6-12 for the first time and doubly measure, and decoct 1-3 hour, for the second time add water 4-10 and doubly measure, decocted 1-3 hour, add water 4-8 for the third time and doubly measure, decocted 1-3 hour, and merged three times decocting liquid, filter, being condensed into relative density is the extractum of 1.05-1.35 (50-85 ℃), drying is ground into fine powder, with above-mentioned fine powder mixing, add each dosage form proper auxiliary materials, make each dosage form by the high rule technology of each dosage form.
2, pill preparation method of the present invention is as follows:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), and drying is ground into fine powder, with above-mentioned fine powder mixing, add refined honey, make water-honeyed pill, coating both got.
3, method for preparing tablet thereof of the present invention is as follows:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), drying, be ground into fine powder, with above-mentioned fine powder and proper auxiliary materials mixing, granulate drying, tabletting namely gets tablet.
4, capsule preparation method thereof of the present invention is as follows:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), drying, be ground into fine powder, with above-mentioned fine powder and proper auxiliary materials mixing, granulate drying, encapsulated, namely get capsule.
5, process for producing granula of the present invention is as follows:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), drying, be ground into fine powder, with above-mentioned fine powder and proper auxiliary materials mixing, granulate drying, pack namely gets granule.
Theory of Chinese medical science: we are made up of 19 flavor medicines, use the Ramulus Cinnamomi warming the meridian and promoting blood circulation, dispersing cold for relieving pain in the side; The Rhizoma Homalomenae wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, pain relieving, detumescence; The Cortex Acanthopancis wind-damp dispelling, bone and muscle strengthening, the arteries and veins of invigorating blood circulation; The Semen Persicae blood stasis removing and clots absorbing; Rhizoma Drynariae the kidney invigorating bone strengthening continues and hinders pain relieving; The Radix Paeoniae Rubra clots absorbing, pain relieving, removing heat from blood, detumescence; The Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing damp and stopping pain; The Radix Angelicae Pubescentis expelling wind and removing dampness, dispersing cold for relieving pain; The Rhizoma Dioscoreae Septemlobae dampness removing goes turbid, and eliminating impediment dispels the wind; The Radix Stephaniae Tetrandrae inducing diuresis to remove edema, wind-expelling pain-stopping; The Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain; The Radix Aconiti Kusnezoffii Preparata expelling wind and removing dampness, pain relieving; The Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling; The Radix Gentianae Macrophyllae wind-damp dispelling, Shujin network, clearind deficient heat; Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; The Caulis Piperis Kadsurae wind-damp dispelling, the meridian dredging, stopping numbness pain.The Radix Angelicae Dahuricae: expelling wind and cold, detumescence and apocenosis; The Radix Dipsaci invigorating the liver and kidney, bone and muscle strengthening, blood circulation regulating; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving; Full side share, and has the effect of strengthening bone and muscle, replenishing QI and blood, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness, numbness relieving and pain relieving; Be mainly used in treating the excess syndrome pain in the lumbar region, the lumbar vertebra arthralgia pain is had better curative effect.
Each flavour of a drug weight proportion of the present invention is the inventor by excavating the abundant natural resources of Chinese medicinal materials of motherland, in conjunction with a large amount of traditional Chinese medical science prescription theories and pharmacological screening test, draws; Technology of the present invention also is inventor's constantly test for many years, and improvement sums up out.Pharmacodynamic test of active extract proves:
Each flavour of a drug weight proportion of the present invention " 52 parts of Ramulus Cinnamomi, 52 parts of Rhizoma Homalomenaes, 52 parts of Cortex Acanthopanciss, 52 parts in Semen Persicae, 26 parts of Rhizoma Drynariae, 78 parts of Radix Paeoniae Rubra, 52 parts of Radix Saposhnikoviaes, 26 parts of 52 parts of, Rhizoma Dioscoreae Septemlobae of Radix Angelicae Pubescentis, 78 parts of Radixs Stephaniae Tetrandrae, 52 parts of Radix Clematidis, 52 parts of Radix Aconiti Kusnezoffii Preparatas, 26 parts of Herba Taxillis, 52 parts of Radix Gentianae Macrophyllae, 52 parts on Flos Carthami, 52 parts of Caulis Piperis Kadsuraes, 78 parts of the Radixs Angelicae Dahuricae, 52 parts of Radix Dipsacis, 26 parts of Radix Angelicae Sinensis." screen weight proportion 1 with prescription: " 70 parts of Ramulus Cinnamomi, 80 parts of Rhizoma Homalomenaes, 40 parts of Cortex Acanthopanciss, 30 parts in Semen Persicae, 80 parts of Rhizoma Drynariae, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 64 parts of Radix Angelicae Pubescentiss, 78 parts of Rhizoma Dioscoreae Septemlobae, 63 parts of Radixs Stephaniae Tetrandrae, 40 parts of Radix Clematidis, 20 parts of Radix Aconiti Kusnezoffii Preparatas, 30 parts of Herba Taxillis, 38 parts of Radix Gentianae Macrophyllae, 30 parts on Flos Carthami, 20 parts of Caulis Piperis Kadsuraes, 50 parts of the Radixs Angelicae Dahuricae, 79 parts of Radix Dipsacis, 50 parts of Radix Angelicae Sinensis." and prescription screening weight proportion 2: " 30 parts of Ramulus Cinnamomi, 50 parts of Rhizoma Homalomenaes, 110 parts of Cortex Acanthopanciss, 50 parts in Semen Persicae, 60 parts of Rhizoma Drynariae, 45 parts of Radix Paeoniae Rubra, 70 parts of Radix Saposhnikoviaes, 50 parts of 30 parts of, Rhizoma Dioscoreae Septemlobae of Radix Angelicae Pubescentis, 53 parts of Radixs Stephaniae Tetrandrae, 50 parts of Radix Clematidis, 50 parts of Radix Aconiti Kusnezoffii Preparatas, 56 parts of Herba Taxillis, 30 parts of Radix Gentianae Macrophyllae, 20 parts on Flos Carthami, 30 parts of Caulis Piperis Kadsuraes, 48 parts of the Radixs Angelicae Dahuricae, 80 parts of Radix Dipsacis, 50 parts of Radix Angelicae Sinensis." and prescription screening weight proportion 3: " 100 parts of Ramulus Cinnamomi, 70 parts of Rhizoma Homalomenaes, 20 parts of Cortex Acanthopanciss, 100 parts in Semen Persicae, 30 parts of Rhizoma Drynariae, 100 parts of Radix Paeoniae Rubra, 26 parts of Radix Saposhnikoviaes, 30 parts of 40 parts of, Rhizoma Dioscoreae Septemlobae of Radix Angelicae Pubescentis, 53 parts of Radixs Stephaniae Tetrandrae, 100 parts of Radix Clematidis, 26 parts of Radix Aconiti Kusnezoffii Preparatas, 60 parts of Herba Taxillis, 45 parts of Radix Gentianae Macrophyllae, 40 parts on Flos Carthami, 30 parts of Caulis Piperis Kadsuraes, 38 parts of the Radixs Angelicae Dahuricae, 40 parts of Radix Dipsacis, 14 parts of Radix Angelicae Sinensis." compare, results of pharmacodynamic test is significantly increased.
Pharmacodynamic test of active extract
One, the preparation of experiment medicine:
1, raw material:
The a group is for of the present invention group: by Ramulus Cinnamomi 52g, Rhizoma Homalomenae 52g, Cortex Acanthopancis 52g, Semen Persicae 52g, Rhizoma Drynariae 26g, Radix Paeoniae Rubra 78g, Radix Saposhnikoviae 52g, Radix Angelicae Pubescentis 52g Rhizoma Dioscoreae Septemlobae 26g, Radix Stephaniae Tetrandrae 78g, Radix Clematidis 52g, Radix Aconiti Kusnezoffii Preparata 52g, Herba Taxilli 26g, Radix Gentianae Macrophyllae 52g, Flos Carthami 52g, Caulis Piperis Kadsurae 52g, Radix Angelicae Dahuricae 78g, Radix Dipsaci 52g, Radix Angelicae Sinensis 26g preparation is (by the present invention: 52 parts of Ramulus Cinnamomi, 52 parts of Rhizoma Homalomenaes, 52 parts of Cortex Acanthopanciss, 52 parts in Semen Persicae, 26 parts of Rhizoma Drynariae, 78 parts of Radix Paeoniae Rubra, 52 parts of Radix Saposhnikoviaes, 26 parts of 52 parts of CAOXIE of Radix Angelicae Pubescentis, 78 parts of Radixs Stephaniae Tetrandrae, 52 parts of Radix Clematidis, 52 parts of Radix Aconiti Kusnezoffii Preparatas, 26 parts of Herba Taxillis, 52 parts of Radix Gentianae Macrophyllae, 52 parts on Flos Carthami, 52 parts of Caulis Piperis Kadsuraes, 78 parts of the Radixs Angelicae Dahuricae, 52 parts of Radix Dipsacis, 26 parts of proportionings of Radix Angelicae Sinensis).
The b group is prescription screening weight proportion 1: by Ramulus Cinnamomi 70g, Rhizoma Homalomenae 80g, Cortex Acanthopancis 40g, Semen Persicae 30g, Rhizoma Drynariae 80g, Radix Paeoniae Rubra 50g, Radix Saposhnikoviae 50g, Radix Angelicae Pubescentis 64g Rhizoma Dioscoreae Septemlobae 78g, Radix Stephaniae Tetrandrae 63g, Radix Clematidis 40g, Radix Aconiti Kusnezoffii Preparata 20g, Herba Taxilli 30g, Radix Gentianae Macrophyllae 38g, Flos Carthami 30g, Caulis Piperis Kadsurae 20g, Radix Angelicae Dahuricae 50g, Radix Dipsaci 79g, Radix Angelicae Sinensis 50g preparation (is pressed prescription screening weight proportion 1: 70 parts of Ramulus Cinnamomi, 80 parts of Rhizoma Homalomenaes, 40 parts of Cortex Acanthopanciss, 30 parts in Semen Persicae, 80 parts of Rhizoma Drynariae, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 78 parts of 64 parts of Rhizoma Dioscoreae Septemlobae of Radix Angelicae Pubescentis, 63 parts of Radixs Stephaniae Tetrandrae, 40 parts of Radix Clematidis, 20 parts of Radix Aconiti Kusnezoffii Preparatas, 30 parts of Herba Taxillis, 38 parts of Radix Gentianae Macrophyllae, 30 parts on Flos Carthami, 20 parts of Caulis Piperis Kadsuraes, 50 parts of the Radixs Angelicae Dahuricae, 79 parts of Radix Dipsacis, 50 parts of proportionings of Radix Angelicae Sinensis).
The c group is prescription screening weight proportion 2: by Ramulus Cinnamomi 30g, Rhizoma Homalomenae 50g, Cortex Acanthopancis 110g, Semen Persicae 50g, Rhizoma Drynariae 60g, Radix Paeoniae Rubra 45g, Radix Saposhnikoviae 70g, Radix Angelicae Pubescentis 30g Rhizoma Dioscoreae Septemlobae 50g, Radix Stephaniae Tetrandrae 53g, Radix Clematidis 50g, Radix Aconiti Kusnezoffii Preparata 50g, Herba Taxilli 56g, Radix Gentianae Macrophyllae 30g, Flos Carthami 20g, Caulis Piperis Kadsurae 30g, Radix Angelicae Dahuricae 48g, Radix Dipsaci 80g, Radix Angelicae Sinensis 50g preparation (is pressed prescription screening weight proportion 2: 30 parts of Ramulus Cinnamomi, 50 parts of Rhizoma Homalomenaes, 110 parts of Cortex Acanthopanciss, 50 parts in Semen Persicae, 60 parts of Rhizoma Drynariae, 45 parts of Radix Paeoniae Rubra, 70 parts of Radix Saposhnikoviaes, 50 parts of 30 parts of Rhizoma Dioscoreae Septemlobae of Radix Angelicae Pubescentis, 53 parts of Radixs Stephaniae Tetrandrae, 50 parts of Radix Clematidis, 50 parts of Radix Aconiti Kusnezoffii Preparatas, 56 parts of Herba Taxillis, 30 parts of Radix Gentianae Macrophyllae, 20 parts on Flos Carthami, 30 parts of Caulis Piperis Kadsuraes, 48 parts of the Radixs Angelicae Dahuricae, 80 parts of Radix Dipsacis, 50 parts of proportionings of Radix Angelicae Sinensis).
The d group is prescription screening weight proportion 3: by Ramulus Cinnamomi 100g, Rhizoma Homalomenae 70g, Cortex Acanthopancis 20g, Semen Persicae 100g, Rhizoma Drynariae 30g, Radix Paeoniae Rubra 100g, Radix Saposhnikoviae 26g, Radix Angelicae Pubescentis 40g Rhizoma Dioscoreae Septemlobae 30g, Radix Stephaniae Tetrandrae 53g, Radix Clematidis 100g, Radix Aconiti Kusnezoffii Preparata 26g, Herba Taxilli 60g, Radix Gentianae Macrophyllae 45g, Flos Carthami 40g, Caulis Piperis Kadsurae 30g, Radix Angelicae Dahuricae 38g, Radix Dipsaci 40g, Radix Angelicae Sinensis 14g preparation (is pressed prescription screening weight proportion 3: 100 parts of Ramulus Cinnamomi, 70 parts of Rhizoma Homalomenaes, 20 parts of Cortex Acanthopanciss, 100 parts in Semen Persicae, 30 parts of Rhizoma Drynariae, 100 parts of Radix Paeoniae Rubra, 26 parts of Radix Saposhnikoviaes, 30 parts of 40 parts of Rhizoma Dioscoreae Septemlobae of Radix Angelicae Pubescentis, 53 parts of Radixs Stephaniae Tetrandrae, 100 parts of Radix Clematidis, 26 parts of Radix Aconiti Kusnezoffii Preparatas, 60 parts of Herba Taxillis, 45 parts of Radix Gentianae Macrophyllae, 40 parts on Flos Carthami, 30 parts of Caulis Piperis Kadsuraes, 38 parts of the Radixs Angelicae Dahuricae, 40 parts of Radix Dipsacis, 14 parts of proportionings of Radix Angelicae Sinensis).
2, the method for making of a group, b group, c group, d group is:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), and drying is ground into fine powder, with above-mentioned fine powder mixing, add refined honey, make water-honeyed pill, coating both got.
3, positive controls: Qinchuan Tongbi tablet is that market is bought.
Two: process of the test and result of the test
Experiment purpose: by to antiinflammatory, the analgesia of pill group of the present invention and b group, c group, d group, improve microcirculation, to the pharmacological experiment study of effects such as the protection of soft tissue injury, treatment adjuvant-induced arthritis; pill group of the present invention and b group, c group, d group are compared, observe the power of its pharmacological action.
Test method: pill group group of the present invention and b group, c group, d organize the influence to Oleum Tiglii inducing mouse auricle edema; To the swollen influence of rat granuloma; The influence of Dichlorodiphenyl Acetate induced mice writhing response; Mice photo-thermal is caused the influence of pain; Microcirculation of mouse auricle is influenced; Influence to the rat acute soft tissue injury; Influence to rat assist agent arthritis.
Experimental result: pill group group of the present invention and b group, c group, d group can significantly alleviate by Oleum Tiglii inducing mouse ease auricle swelling; Cotton balls is caused that the granuloma of rat has the obvious suppression effect; Can significantly reduce mice and cause that by glacial acetic acid pain turns round the number of times of body; Can significantly improve photo-thermal and cause the pain threshold of mice bitterly; Can significantly expand the thin artery and vein caliber of Mice Auricle, increase open capillary vessel number; Rat acute soft tissue swelling due to hitting had significantly alleviate effect; Can significantly alleviate the swelling degree of the adjuvant arthritis rats foot sole of the foot.
Conclusion: pill group of the present invention than antiinflammatory, the analgesia of b group, c group, d group, improve microcirculation, to the protection of soft tissue injury,
Effect such as treatment adjuvant-induced arthritis etc. is strong, so pill group of the present invention is stronger than b group, c group, the pharmacological action of d group.
One, to the influence of Oleum Tiglii inducing mouse auricle edema
Experiment material
1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.
2, medicine: pill group group of the present invention, b group, c group, d group; Oral, a 2g, 3 times on the one.Qinchuan Tongbi tablet; Oral, one time 3,3 times on the one.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group is irritated stomach with the distilled water of volume; Pill group of the present invention, b group, c group and d group gastric infusion are 6.4g crude drug/kg; Qinchuan Tongbi tablet gastric infusion 1.2g crude drug/kg.. successive administration 7d, every day 1 time, behind the last administration 1h, the two sides caused inflammation before and after the Oleum Tiglii mixture 0.05ml that will now join the same day was applied to the mouse right ear exterior feature, and left ear is coated with equivalent normal saline usefulness in contrast, behind the 2h mice etherization is put to death, cut two ears along the auricle line, corneal trephine with diameter 8mm downcuts auricle at the same position of left and right sides auricle, accurately weighs respectively, and the difference of two auricle weight is as the swelling degree.Experimental result: see Table 1
The influence of table 1 pair Oleum Tiglii inducing mouse auricle edema
Compare * * P＜0.01 with matched group; With pill group of the present invention than Δ P＜0.05.
The result shows: pill group of the present invention, Qinchuan Tongbi tablet, b group, c group and d group can significantly alleviate by Oleum Tiglii inducing mouse ease auricle swelling the utmost point significant difference of having compared with matched group (P＜0.01); Pill group of the present invention is organized the significant difference (P＜0.05) of having compared with Qinchuan Tongbi tablet, b group, c group and d.As seen, pill group of the present invention is stronger than Qinchuan Tongbi tablet, b group, c group and d group antiinflammatory action.
Two, to the swollen influence of rat granuloma
Experiment material
1, animal: SD kind rat, male and female have concurrently, body weight 150～200g.
2, medicine: pill group group of the present invention, b group, c group, d group; Oral, a 2g, 3 times on the one.Qinchuan Tongbi tablet; Oral, one time 3,3 times on the one.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of SD kind rats, male and female half and half, body weight 150～200g is divided into 6 groups at random, 10 every group.During test, the rat chesk hair is wiped out in the ether light anaesthesia, iodine disinfection cuts skin of chest, fills in each one of the aseptic cotton balls of 30mg (soaking and oven dry with mycillin mixed liquor 0.2ml behind the autoclaving) respectively to two forelimb oxters from otch, skin suture, intramuscular injection green grass or young crops, chain enzyme infection.Postoperative 1h gastric infusion, matched group are irritated stomach with the distilled water of volume; Pill group of the present invention, b group, c group and d group gastric infusion are 6.4g crude drug/kg; Qinchuan Tongbi tablet gastric infusion 1.2g crude drug/kg.Successive administration 7d puts to death rat in 8d cervical vertebra dislocation every day 1 time, peels off the cotton balls granulation tissue, in 60 ℃ of baking ovens behind the baking 12h, and weighing.With claim weight deduct cotton balls weight and namely get granuloma weight.Experimental result: see Table 2
The influence that table 2 pair rat granuloma is swollen
Compare * * P＜0.01 with matched group; With pill group of the present invention than Δ P＜0.05.
The result shows: pill group of the present invention, Qinchuan Tongbi tablet, b group, c group and d group cause that to cotton balls the granuloma of rat has the obvious suppression effect, compared utmost point significant difference (P＜0.01) with matched group, pill group of the present invention is organized the significant difference (P＜0.05) of having compared with Qinchuan Tongbi tablet, b group, c group and d.As seen, pill group of the present invention than Qinchuan Tongbi tablet, b group,
C group and d group antiinflammatory action are strong.
Three, the influence of Dichlorodiphenyl Acetate induced mice writhing response
Experiment material
1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.
2, medicine: pill group group of the present invention, b group, c group, d group; Oral, a 2g, 3 times on the one.Qinchuan Tongbi tablet; Oral, one time 3,3 times on the one.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of kunming mices, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group is irritated stomach with the distilled water of volume; Pill group of the present invention, b group, c group and d group gastric infusion are 6.4g crude drug/kg; Qinchuan Tongbi tablet gastric infusion 1.2g crude drug/kg.Successive administration 7d, every day 1 time, behind the last administration 1h, the equal lumbar injection 0.7% acetic acid 0.2ml/ of every Mus, the abdominal part indent appears in mice, and trunk and hind leg are upheld, writhing responses such as hips up, mouse writhing number of times in the record 15min, and calculate the analgesia rate.Experimental result: see Table 3
The influence of table 3 Dichlorodiphenyl Acetate induced mice writhing response
Compare * * P＜0.01 with matched group; With pill group of the present invention than Δ P＜0.05.
The result shows: pill group of the present invention, Qinchuan Tongbi tablet, b group, c group and d group can significantly reduce mice and cause that by glacial acetic acid pain turns round the number of times of body, compare the difference (P＜0.01) that utmost point significance is arranged with matched group; Pill group of the present invention is organized the significant difference (P＜0.05) of having compared with Qinchuan Tongbi tablet, b group, c group and d.As seen, pill group of the present invention is stronger than the analgesic activity of Qinchuan Tongbi tablet, b group, c group and d group.
Four, mice photo-thermal is caused the influence of pain
Experiment material
1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.
2, medicine: pill group group of the present invention, b group, c group, d group; Oral, a 2g, 3 times on the one.Qinchuan Tongbi tablet; Oral, one time 3,3 times on the one.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
Earlier clean the Mus tail with 75% ethanol before the test,, measure mice and be somebody's turn to do the incubation period of place's whipping reaction as pain threshold as the photostimulation point with 1/3 place under the afterbody.Measure the preceding basic pain threshold of mice administration earlier, basic pain threshold is rejected less than 2s or greater than irritation or the blunt animal of 10s.60 of mices after the screening, male and female half and half are divided into 6 groups at random, 10 every group.Matched group is irritated stomach with the distilled water of volume; Pill group of the present invention, b group, c group and d group gastric infusion are 6.4g crude drug/kg; Qinchuan Tongbi tablet gastric infusion 1.2g crude drug/kg.Successive administration 7d, every day 1 time, behind the last administration 1h, mice is carried out photo-thermal to be stimulated, and pain threshold stops to stimulate during greater than 15s, in order to avoid scalded skin.Occur the time of whipping reaction after the record administration, pain threshold was as difference before the pain threshold after the medication deducted medication.Experimental result: see Table 4
Table 4 pair mice photo-thermal causes the influence of pain
Compare * * P＜0.01 with matched group; With pill group of the present invention than Δ P＜0.05.
The result shows: pill group of the present invention, Qinchuan Tongbi tablet, b group, c group and d group can significantly improve the pain threshold that photo-thermal causes the pain mice, have compared utmost point significant difference (P＜0.01) with matched group; Pill group of the present invention is organized the significant difference (P＜0.05) of having compared with Qinchuan Tongbi tablet, b group, c group and d.As seen, pill group of the present invention than Qinchuan Tongbi tablet, b group, c group and d group analgesic activity strong.
Five, microcirculation of mouse auricle is influenced
Experiment material
1, animal: Kunming kind female mice, body weight 18～22g.
2, medicine: pill group group of the present invention, b group, c group, d group; Oral, a 2g, 3 times on the one.Qinchuan Tongbi tablet; Oral, one time 3,3 times on the one.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of Kunming kind female mices, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group is irritated stomach with the distilled water of volume; Pill group of the present invention, b group, c group and d group gastric infusion are 6.4g crude drug/kg; Qinchuan Tongbi tablet gastric infusion 1.2g crude drug/kg.Successive administration 7d, every day 1 time, behind the 7d administration 1h, mouse peritoneal injection pentobarbital sodium 84mg/kg anesthesia back is auricle fixedly, under microcirculation microscope, directly measures the caliber size of Mice Auricle arteriole, thin vein; The auricle capillary vessel number is the square root of eyepiece micrometer horizontal stroke, vertical coordinate total length (1.0mm) the capillary vessel number product of cutting.Experimental result: see Table 5
Table 5 pair microcirculation of mouse auricle influence
Compare * * P＜0.01 with matched group; With pill group of the present invention than Δ P＜0.05.
The result shows: pill group of the present invention, Qinchuan Tongbi tablet, b group, c group and d group can significantly be expanded the thin artery and vein caliber of Mice Auricle, increase open capillary vessel number, have compared utmost point significant difference (P＜0.01) with matched group; Pill group of the present invention is organized the significant difference (P＜0.05) of having compared with Qinchuan Tongbi tablet, b group, c group and d.As seen, pill group of the present invention than Qinchuan Tongbi tablet, b group, c group and d group to improve microcirculation strong.
Six, to the influence of rat acute soft tissue injury
Experiment material.
1, animal: SD kind rat, male and female have concurrently, body weight 150～200g.
2, medicine: pill group group of the present invention, b group, c group, d group; Oral, a 2g, 3 times on the one.Qinchuan Tongbi tablet; Oral, one time 3,3 times on the one.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
At the about 2cm * 2cm of rat right hind leg outside partial zones area, next day after losing hair or feathers, rat is fixed on the plank, the PVC hollow pipe of getting an internal diameter and be 1.5cm, long 100cm vertically places on the soft tissue of the rat right hind leg outside, then the blunt nosed ferrum pestle of a heavy 80g from top to down freely falling body impact rat right hind leg outside soft tissue continuous 3 times, cause the about 4cm of area
2The non-open soft tissue injury model that obvious subcutaneous hemorrhage and swelling are arranged makes the damage location of every rat close as far as possible during operation.To make 60 of SD kind rats organizing damage model by last method, male and female half and half, body weight 150～200g is divided into 6 groups at random, 10 every group.Matched group is irritated stomach with the distilled water of volume; Pill group of the present invention, b group, c group and d group gastric infusion are 4.4g crude drug/kg; Qinchuan Tongbi tablet gastric infusion 1.0g crude drug/kg.Successive administration 7d, behind the last administration 1h, measures the poor of right limb damage location and the same position of left limb girth with tape, as swelling number of degrees value at every day 1 time.Experimental result: see Table 6
The influence of table 6 pair rat acute soft tissue injury
Compare * * P＜0.01 with matched group; With pill group of the present invention than Δ P＜0.05.
The result shows: pill group of the present invention, Qinchuan Tongbi tablet, b group, c group and d group have rat acute soft tissue swelling due to hitting and significantly alleviate effect, have compared utmost point significant difference (P＜0.01) with matched group; Pill group of the present invention is organized the significant difference (P＜0.05) of having compared with Qinchuan Tongbi tablet, b group, c group and d.As seen, pill group of the present invention is stronger to the protection of acute soft tissue injury than Qinchuan Tongbi tablet, b group, c group and d group.
Seven, to the influence of rat assist agent arthritis
Experiment material
1, animal: SD kind rat, male and female have concurrently, body weight 150～200g.
2, medicine: pill group group of the present invention, b group, c group, d group; Oral, a 2g, 3 times on the one.Qinchuan Tongbi tablet; Oral, one time 3,3 times on the one.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of SD kind rats, male and female half and half, body weight 150～200g, be divided into 6 groups at random, every group 10, cause the scorching preceding right back sufficient sole of the foot Zhou Jing of portion of rat with vernier caliper measurement, the right back sufficient sole of the foot intradermal injection Freund's complete adjuvant 0.05ml of every Mus causes inflammation then, 7d gastric infusion thing behind the Yu Zhiyan, matched group are irritated stomach with the distilled water of volume; Pill group of the present invention, b group, c group, d group gastric infusion are 4.4g crude drug/kg; Qinchuan Tongbi tablet gastric infusion 1.0g crude drug/kg.Successive administration 14d, causes after the 21d administration of scorching back 1h with the right back sufficient sole of the foot Zhou Jing of portion of vernier caliper measurement rat at every day 1 time.So that scorching metapedes sole of the foot Zhou Jing with cause the difference of scorching front foot sole of the foot Zhou Jing as paw swelling.Experimental result: see Table 7
The influence of table 7 pair rat assist agent arthritis
Compare * * P＜0.01 with matched group; With pill group of the present invention than Δ P＜0.05.
The result shows:. pill group of the present invention, Qinchuan Tongbi tablet, b group, c group and d group can significantly alleviate the swelling degree of the adjuvant arthritis rats foot sole of the foot, compare the difference (P＜0.01) that utmost point significance is arranged with matched group; Pill group of the present invention is organized the significant difference (P＜0.05) of having compared with Qinchuan Tongbi tablet, b group, c group and d.As seen, pill group of the present invention is than the treatment adjuvant-induced arthritis of Qinchuan Tongbi tablet, b group, c group and d group, and the effect of expelling wind and removing dampness is strong.
Experimental result: pill group group of the present invention and b group, c group, d group can significantly alleviate by Oleum Tiglii inducing mouse ease auricle swelling; Cotton balls is caused that the granuloma of rat has the obvious suppression effect; Can significantly reduce mice and cause that by glacial acetic acid pain turns round the number of times of body; Can significantly improve photo-thermal and cause the pain threshold of mice bitterly; Can significantly expand the thin artery and vein caliber of Mice Auricle, increase open capillary vessel number; Rat acute soft tissue swelling due to hitting had significantly alleviate effect; Can significantly alleviate the swelling degree of the adjuvant arthritis rats foot sole of the foot.
Conclusion: pill group of the present invention than antiinflammatory, the analgesia of b group, c group, d group, improve microcirculation, to the protection of soft tissue injury,
Effect such as treatment adjuvant-induced arthritis etc. is strong, so pill group of the present invention is stronger than b group, c group, the pharmacological action of d group.Toxicological experiment:
Acute toxicity testing is the result show: with pill group group Cmax of the present invention, maximum volume gastric infusion, successive administration is 3 times in 24h, each 4h at interval, and accumulation medicine total amount reaches 48g crude drug/kg, is equivalent to 135.5 times of clinical plan consumption.In the 7d, mice activity, feed, drainage are all normal after the administration, well-grown, and the hair color light, its average body weight average increases with the prolongation of test period.8d puts to death every mice perusal heart of back dissection, liver, spleen, lung, kidney, brain, thymus, uterus, stomach, intestinal etc. and does not all find color and paramophia, fails to measure LD
50Show that pill group group of the present invention do not have acute toxic reaction.
Long term toxicity test is the result show: pill group component of the present invention is that basic, normal, high dosage is respectively 8,15,30g crude drug/kg/d, be equivalent to 22.6,42.3,84.7 times of clinical dosage, gastric infusion is after 12 weeks, pill group group of the present invention does not all have tangible influence to general situation, hematological indices, the blood parameters of animal, and system's dissection, organ coefficient and histopathological examination be no abnormal pathological change also.2 weeks of drug withdrawal are not seen obvious change yet.Pill group group of the present invention is not found overt toxicity reaction and delayed toxicity, reaction in long term toxicity test.As seen, pill group group non-toxic reaction of the present invention, long-term prescription is safe and reliable.
The specific embodiment
1, the preparation of pill of the present invention:
Prescription:
Ramulus Cinnamomi 52g Rhizoma Homalomenae 52g Cortex Acanthopancis 52g Semen Persicae 52g
Rhizoma Drynariae 26g Radix Paeoniae Rubra 78g Radix Saposhnikoviae 52g Radix Angelicae Pubescentis 52g
Rhizoma Dioscoreae Septemlobae 26g Radix Stephaniae Tetrandrae 78g Radix Clematidis 52g Radix Aconiti Kusnezoffii Preparata 52g
Herba Taxilli 26g Radix Gentianae Macrophyllae 52g Flos Carthami 52g Caulis Piperis Kadsurae 52g
Radix Angelicae Dahuricae 78g Radix Dipsaci 52g Radix Angelicae Sinensis 26g
Preparation method:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), and drying is ground into fine powder, with above-mentioned fine powder mixing, add refined honey, make water-honeyed pill, coating both got.
2, the preparation of capsule of the present invention:
Prescription:
Ramulus Cinnamomi 52g Rhizoma Homalomenae 52g Cortex Acanthopanacis Radicis 52g Semen Persicae 52g
Rhizoma Drynariae 26g Radix Paeoniae Rubra 78g Radix Saposhnikoviae 52g Radix Angelicae Pubescentis 52g
Rhizoma Dioscoreae Septemlobae 26g Radix Stephaniae Tetrandrae 78g Radix Clematidis 52g Radix Aconiti Kusnezoffii Preparata 52g
Herba Taxilli 26g Radix Gentianae Macrophyllae 52g Flos Carthami 52g Caulis Piperis Kadsurae 52g
Radix Angelicae Dahuricae 78g Radix Dipsaci 52g Radix Angelicae Sinensis 26g
Preparation method:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), drying, be ground into fine powder, with above-mentioned fine powder and proper auxiliary materials mixing, granulate drying, encapsulated, namely get capsule.
3, the preparation of tablet of the present invention:
Prescription:
Ramulus Cinnamomi 52g Rhizoma Homalomenae 52g Cortex Acanthopancis 52g Semen Persicae 52g
Rhizoma Drynariae 26g Radix Paeoniae Rubra 78g Radix Saposhnikoviae 52g Radix Angelicae Pubescentis 52g
Rhizoma Dioscoreae Septemlobae 26g Radix Stephaniae Tetrandrae 78g Radix Clematidis 52g Radix Aconiti Kusnezoffii Preparata 52g
Herba Taxilli 26g Radix Gentianae Macrophyllae 52g flower 52g Caulis Piperis Kadsurae 52g
Radix Angelicae Dahuricae 78g Radix Dipsaci 52g Radix Angelicae Sinensis 26g
Preparation method:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), drying, be ground into fine powder, with above-mentioned fine powder and proper auxiliary materials mixing, granulate drying, tabletting namely gets tablet.
4, the preparation of granule of the present invention:
Prescription:
Ramulus Cinnamomi 52g Rhizoma Homalomenae 52g Cortex Acanthopanacis Radicis 52g Semen Persicae 52g
Rhizoma Drynariae 26g Radix Paeoniae Rubra 78g Radix Saposhnikoviae 52g Radix Angelicae Pubescentis 52g
Rhizoma Dioscoreae Septemlobae 26g Radix Stephaniae Tetrandrae 78g Radix Clematidis 52g Radix Aconiti Kusnezoffii Preparata 52g
Herba Taxilli 26g Radix Gentianae Macrophyllae 52g Flos Carthami 52g Caulis Piperis Kadsurae 52g
Radix Angelicae Dahuricae 78g Radix Dipsaci 52g Radix Angelicae Sinensis 26g
Preparation method:
More than 19 the flavor, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae are ground into fine powder, and be standby; 17 flavors such as all the other Ramulus Cinnamomi decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, merge decocting liquid twice, filter, being condensed into relative density is the extractum of 1.05-1.32 (60-70 ℃), drying, be ground into fine powder, with above-mentioned fine powder and proper auxiliary materials mixing, granulate drying, pack namely gets granule.
Claims (2)
1. lumbar vertebra arthralgia pain Chinese medicine composition is characterized in that described Chinese medicine composition made by following raw materials by weight proportions:
2. according to the described Chinese medicine composition of claim 1, it is characterized in that the dosage form of described Chinese medicine composition is: pill, capsule, tablet, granule or oral liquid.
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| CN 201110427591 CN102441089B (en) | 2011-12-16 | 2011-12-16 | Traditional Chinese herbal composition for lumbar vertebra rheumatic pain and preparation method thereof |
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| CN1150922C (en) * | 2001-02-21 | 2004-05-26 | 杨玉明 | A medicated liquor for treating arthralgia syndrome such as rheumatism and rheumatoid diseases |
| CN102058823A (en) * | 2009-09-21 | 2011-05-18 | 王解清 | Traditional Chinese medicine preparation for treatment of prolapse and hyperplasia of human cervical and lumbar vertebra |
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