CN102429857A - Method and device for performing physical targeting positioning on magnetic medicine by using permanent magnets - Google Patents
Method and device for performing physical targeting positioning on magnetic medicine by using permanent magnets Download PDFInfo
- Publication number
- CN102429857A CN102429857A CN2011103898516A CN201110389851A CN102429857A CN 102429857 A CN102429857 A CN 102429857A CN 2011103898516 A CN2011103898516 A CN 2011103898516A CN 201110389851 A CN201110389851 A CN 201110389851A CN 102429857 A CN102429857 A CN 102429857A
- Authority
- CN
- China
- Prior art keywords
- magnet
- permanent
- magnetic
- localized
- magnets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/002—Magnetotherapy in combination with another treatment
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Magnetic Treatment Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a method for performing physical targeting positioning on a magnetic medicine by using permanent magnets, which comprises the following steps of: 1, tightly arranging three permanent magnets I, II and III with regular shapes in turn in the same direction, wherein the two permanent magnets I and III positioned on two sides have the same shape and size and are eudipleural by taking the central line of the permanent magnet II positioned in the middle as a symmetric axis, the magnetization directions of the three permanent magnets are arranged in a Halbach array mode along the arrangement direction, and a surface for targeting positioning, namely a working surface is continuous; and 2, performing targeting positioning on the magnetic medicine by using a magnet device manufactured according to the step 1. The invention also discloses a device for performing physical targeting positioning on the magnetic medicine by using the permanent magnets. Compared with the conventional unilaterally applied magnet, the device has the advantage that: higher magnetic field intensity and magnetic field gradient can be provided on the basis of the same action depth; meanwhile, the device has an optimized structure, is easy to process, can overcome the defect of low effective action depth of the common targeting positioning magnet, and is particularly suitable for occasions on which magnetic medicine particles are needed to be positioned in medium depth.
Description
Technical field
The present invention relates to a kind of employing permanent-magnet and realize magnetic and medicated Physical Target, also relate to a kind of device simultaneously to localized method.
Background technology
Cancer is commonly encountered diseases, the frequently-occurring disease of serious harm human health, is that disease causes one of main causes of death.Cancer is through reducing or reduce cell control and normal mature mechanism.Its characteristic comprises cell hyperproliferation, undifferentiated cell and tissue, adjacent tissue is invaded and shifted.Treatment means comprises excision, chemotherapy, immunization therapy and radiotherapy etc.Owing to eradicate cancerous cell fully and could successfully cure cancer, but often because the influence of factors such as the location of tumor, infiltration metastasis, the surgical excision operation can not be eradicated cancerous cell fully, this in this case, chemotherapy is necessary.And conventional chemotherapeutics absorbs the entering blood circulation from injected place or through gastrointestinal; Move to heart and arrive other zone of whole body again; For the zonule that medicine is wanted targeting, the efficient of this method is very low, wants to reach and hopes that concentration just causes using the HDC agent; Big drug dose can obviously improve curative effect of medication but increase the general toxic reaction that drug dose certainly will increase medicine, and the clinical practice of chemotherapeutics is very limited.Therefore the toxicity that the local concentration that how to improve medicine reduces whole body simultaneously is the heat subject of research always.
As far back as the beginning of this century, Paul Ehrlich has just proposed the imagination of targeted drug, promptly is transported to target organ to the medicine orientation with certain carrier with special affinity and plays a role.Three parts that this type medicament carrier system is coordinated by medicine, guiding mechanism and carrier each other constitute.The seventies in 20th century Widder (Seyei A., Widder K., Czerlinski G., J.Appl.Phys.1978.) etc. a nearly step proposes the notion of magnetic control target to drug delivery system, and has carried out the research of drug loaded magnetic microgranule.The magnetic control drug targeted therapy is to be configured to medicine and suitable magnetic material and necessary auxiliary material magnetic and medicated; External magnetic field location through enough strong arrives and is positioned tumor tissues selectively with the blood flow operation, on cell or subcellsular level, brings into play drug action; Therefore normal structure there is not too big influence; Be applicable to the targeted therapy of kinds of tumors, in recent years, become the focus of tumor targeting therapy and novel pharmaceutical formulation research already.
Magnetic drug targeting mainly need solve three basic technologies: the 1. particulate stability of magnetic drug-carrying: though the particulate preparation of magnetic drug-carrying and uncomplicated, problems such as its postpone of a specified duration is merged each other, drug leakage solve fully; 2. the optimization of external magnetic field system setting: the location, magnetic field intensity, magnetic field gradient, the standing time that relate to magnetic field; 3. motion transmission and the kinetic theory must the development support magnetic targeted drug in tumor vessel, sent are to confirm relations such as best drug loaded magnetic particle size, magnetic fluid concentration, viscosity, external magnetic field intensity and injection rate.What the present invention relates to is 2. individual technical problem.
A key issue that relates to magnetic and medicated granule targeting in the human body is the degree of depth problem of target site.In general, target site surpasses 2cm in human body, just is difficult to use the external magnetic field targeting, because magnetic field intensity increases along with distance and reduces.On the other hand, nearly all medicine all sends through liver, and at liver, the medicine non-activity that all becomes.In addition, just require stronger magnetic field in the large artery trunks, because the blood linear velocity in the large artery trunks than the mobile fast 50-100 of blood capillary doubly is approximately 0.5cm/s if remain on the magnetic medicine carrier granule.
In order the outside magnetic field guiding to make magnetic and medicated particle aggregation at darker targeting moiety down; Usually there are two kinds of technology to realize: 1. to implant assisted magnetic drug targeting localization method; Principle is considered through placing a magnet tinsel at regional area exactly; Utilize of the distortion of tinsel tip, to strengthen partial magnetic field intensity of target site and gradient, so that target site has higher magnetic retentivity to external magnetic field; 2. adopt superpower electric magnet and superconductor to produce magnetic field and the bigger magnetic field gradient stronger than general magnet.But these two kinds of technology all have separately us be reluctant the shortcoming faced, invade operation, big energy consumption and high difficulty of processing and cost like needs.
Therefore, need the suitable permanent-magnet array of design to come the more targeting target of position, deep of targeting to produce bigger magnetic field intensity and magnetic field gradient.
Summary of the invention
In view of this; One of the object of the invention provides a kind of employing permanent-magnet and is used for magnetic and medicated Physical Target to localized method; Two of the object of the invention provides a kind of employing permanent-magnet and is used for magnetic and medicated Physical Target to localized device; This device can guide magnetic and medicated granule effective accumulative external permanent-magnet device in darker position (more than the 3cm) in human body, and just the targeting at human lung or other middle-shallow layer position location this degree of depth of 3-4cm is enough.Scheme of the present invention has overcome the part shortcoming and the restriction of aforementioned two kinds of technology, compare with targeting magnet mechanism of the same type have that simple in structure, permanent magnet utilization ratio is high, advantages such as big, the EFFECTIVE RANGE length of magnetic field gradient, low cost of manufacture on the depth direction.
One of the object of the invention is realized through following technical scheme:
Employing permanent-magnet of the present invention is used for magnetic and medicated Physical Target to localized method, may further comprise the steps:
Step 1: permanent-magnet I, II and the III of three regular shape are closely arranged by same direction successively; Wherein, It is identical with size and be the axis of symmetry left-right symmetric with the center line that is positioned at intermediary permanent-magnet II to be positioned at the shape of two permanent-magnet I, III of both sides, and along orientation, the direction of magnetization of three permanent-magnets is arranged by the Halbach array way; Be used for localized that one side of targeting, promptly work surface is continuous;
Step 2: will be used for magnetic and medicated targeting location according to the magnet apparatus that step 1 is processed apart from magnet surface 0-4cm.
Further, in step 1, in order to adapt to human body or other application the surface configuration of certain radian is arranged, two permanent-magnets on both sides can symmetricly rotate up 0 °-10 ° angle respectively;
Further, the permanent magnet material of permanent-magnet is neodymium iron boron, SmCo or ferrite;
Further, said permanent-magnet is square;
Two of the object of the invention is realized through following technical scheme:
Said device comprises that permanent-magnet I, permanent-magnet II and the permanent-magnet III of three regular shape and three permanent-magnets closely arrange by same direction successively; Wherein, It is identical with size and be the axis of symmetry left-right symmetric with the center line that is positioned at intermediary permanent-magnet II to be positioned at the shape of two permanent-magnet I, III of both sides, and along orientation, the direction of magnetization of three permanent-magnets is arranged by the Halbach array way; Be used for localized that one side of targeting, promptly work surface is continuous;
Further, the permanent magnet material of permanent-magnet is neodymium iron boron, SmCo or ferrite;
Further, adopt the high strength glue bond between the said permanent-magnet;
As another kind magnet connected mode more flexibly; Be to adopt the non-magnetic conduction support of scalable to fix permanent-magnet, the non-magnetic conduction support of said scalable is used to regulate the angle between the work surface of work surface and permanent-magnet II of work surface and permanent-magnet III of permanent-magnet I;
Further, said permanent-magnet is square.
The invention has the beneficial effects as follows:
Method of the present invention is implemented easily, and is respond well, than prior art, on EFFECTIVE RANGE, has special advantages, has the magnetic field intensity and the magnetic field gradient that can provide higher on the identical depth of interaction; And according to the device that method and thought makes have more that simple in structure, permanent magnet utilization ratio is high, magnetic field gradient is big on the depth direction, EFFECTIVE RANGE long, advantage of low manufacturing cost; Its structure optimization has only stray magnetic field seldom in the side that magnet apparatus does not utilize; Handling ease; That uses that permanent-magnet provided by the invention processes is used for the localized magnet apparatus of magnetic and medicated targeting; Can reach 9 teslas/more than the rice with magnet surface apart from the magnetic field gradient at place, the working region of 3cm; This magnet array can overcome the shortcoming of ordinary target to positioning magnet useful effect depth as shallow, for the occasion particularly suitable that requires at the magnetic and medicated microgranule of middle degree of depth spots localization.
Other advantages of the present invention, target and characteristic will be set forth in description subsequently to a certain extent; And to a certain extent; Based on being conspicuous to those skilled in the art, perhaps can from practice of the present invention, obtain instruction to investigating of hereinafter.Target of the present invention and other advantages can realize and obtain through following description and claims.
Description of drawings
In order to make the object of the invention, technical scheme and advantage clearer, will combine accompanying drawing that the present invention is made further detailed description below, wherein:
Fig. 1 is a kind of 3-D view that is used for magnetic and medicated Physical Target to localized permanent-magnet device of the present invention;
Fig. 2 is a kind of top plan view that is used for magnetic and medicated Physical Target to localized permanent-magnet device of the present invention;
Fig. 3 is a kind of side cutaway view that is used for magnetic and medicated Physical Target to the gyration situation of localized permanent-magnet device of the present invention;
Fig. 4 is used for magnetic and medicated Physical Target has added side cutaway view from shell to localized permanent-magnet device for the present invention is a kind of;
Fig. 5 is used for magnetic and medicated Physical Target has added top plan view from shell to localized permanent-magnet device for the present invention is a kind of;
Fig. 6 is magnetic field intensity and the Gradient distribution on the 0-4cm line of magnet surface center;
Fig. 7 is apart from magnetic field intensity and Gradient distribution on the horizontal 1cm line in 3cm place, magnet surface center;
Fig. 82,3 turns over magnetic field intensity and the Gradient distribution on the 0-4cm line of magnet surface center behind the certain angle;
Fig. 92,3 turns over behind the certain angle apart from the magnetic field gradient profile on the horizontal 1cm line in 3cm place, magnet surface center;
Figure 10 is the structural representation of the non-magnetic conduction support of adjustable-angle;
Figure 11 is the structural representation of non-magnetic conduction support of the adjustable-angle of embodiment 5;
Figure 12 is the structural representation of non-magnetic conduction support of the adjustable-angle of embodiment 6;
Figure 13 is the structural representation of the rotation rack of embodiment 6;
Figure 14 is the structural representation of the base of embodiment 6;
Hinged place profile when Figure 15 keeps being in the axial restraint position for the button spare of embodiment 6.
The specific embodiment
Below will carry out detailed description to the preferred embodiments of the present invention with reference to accompanying drawing.Should be appreciated that preferred embodiment has been merely explanation the present invention, rather than in order to limit protection scope of the present invention.
Employing permanent-magnet of the present invention is used for magnetic and medicated Physical Target to localized method, may further comprise the steps:
Step 1: permanent-magnet I, II and the III of three regular shape are closely arranged by same direction successively; Wherein, It is identical with size and be the axis of symmetry left-right symmetric with the center line that is positioned at intermediary permanent-magnet II to be positioned at the shape of two permanent-magnet I, III of both sides, and along orientation, the direction of magnetization of three permanent-magnets is arranged by the Halbach array way; Be used for localized that one side of targeting, promptly work surface is continuous; Wherein the permanent magnet material of magnet is neodymium iron boron, SmCo or ferrite.
Step 2: will be used for magnetic and medicated targeting location according to the magnet apparatus that step 1 is processed apart from magnet surface 0-4cm.
Based on the thought of said method, the invention allows for a kind of employing permanent-magnet and be used for magnetic and medicated Physical Target to localized device, below in conjunction with accompanying drawing and embodiment this device is further described.In the accompanying drawings, 1,2 and 3 represent center magnet, left side magnet and the right magnet, 4 stainless steel casings respectively.In institute's drawings attached, represent the size and Orientation of permanent magnet magnetic moment with thick arrow.
In brief; Embodiments of the invention are a kind of specific arrangement of permanent magnet; Can be used as the localized external magnet of magnetic and medicated targeting mechanism, on bigger distance, generate, gradient higher more greatly and the uniform more space magnetic field of cross direction profiles than existing permanent magnet arrangement intensity.The Halbach that the permanent magnet arrangement of embodiment is based on permanent magnet arranges.The magnetic field intensity, gradient and the horizontal homogeneity that increase can fetter more magnetic and medicated microgranule on bigger distance, to reach better therapeutic effect.
The permanent magnet material of used permanent-magnet is a Nd-Fe-Bo permanent magnet material among the embodiment, if select the SmCo or the ferrite permanent-magnet materials of appropriate size for use, also can realize identical effect.
Fig. 1 representes a kind of 3-D view that is used for magnetic and medicated Physical Target to localized permanent-magnet device according to first embodiment of the invention; Fig. 2 is according to a kind of top plan view that is used for magnetic and medicated Physical Target to localized permanent-magnet device of first embodiment of the invention.
As shown in the figure, the permanent-magnet array of present embodiment comprises the permanent-magnet II 2 and permanent-magnet III 3 that is arranged on intermediary permanent-magnet I 1 and is arranged on permanent-magnet I both sides.The used permanent magnet material trade mark is N38 in the present embodiment, the remanent magnetism Br=1.28T of material, HCJ iHc >=12Koe, maximum magnetic energy product (BH) max=37MGOe.Use identical permanent magnet material to sinter cross sectional shape into and be the square of the length of side as 40mm, length is the bar-shaped permanent magnet blocks of 50mm.In fact; Cross sectional shape adopts square or circular or other regular shapes all are fine; But the surface of the magnet array that the square-section is formed continuously; The magnetic field cross direction profiles that produces on nearly surface is more even, helps carrying out magnetic and medicated targeting and transports, and the shape of two of both sides permanent-magnets and size will be with respect to intermediary permanent-magnet symmetries in addition;
Because the error when permanent magnet magnetizes; It is well-balanced as far as possible for space magnetic field is distributed; When actual assembled, should from a plurality of permanent magnet blocks, measure three magnets that Surface field is approaching of selection through Gaussmeter, be arranged in order by the direction of magnetization that marks among Fig. 1 with three magnets electing, the direction of magnetization of three permanent-magnets is seen from left to right successively; The direction of magnetization that the back is one is the previous result who is rotated counterclockwise 90 °, promptly linear Halbach array way.In the present embodiment; Adopting high strength more directly to bond together Fig. 6 is magnetic field intensity and Gradient distribution on the 0-4cm line of magnet surface center; Can find out in magnetic field intensity and gradient to reach 300mT and 9T/m respectively that this has reached the basic demand of constraint magnetic nanoparticle in blood vessel apart from surperficial 3cm place.Fig. 7 is apart from magnetic field intensity and Gradient distribution on the horizontal 1cm line in 3cm place, magnet surface center; Can find out in magnetic field intensity and gradient near target area (3cm) all has good uniformity, so just can near this zone, assemble more magnetic nanoparticle.
In order to adapt to human body different parts or some application the surface configuration of certain radian is arranged; Horizontal operation face with respect to embodiment 1; Embodiment 2 is work surfaces of curved crease line; Two permanent-magnets that are both sides can symmetricly rotate up certain angle respectively, and this that face (work surface) that will guarantee that wherein the permanent-magnet device utilized is continuous, and intermediary permanent-magnet remains unchanged.
Fig. 3 is a kind of side cutaway view that is used for magnetic and medicated Physical Target to the gyration situation of localized permanent-magnet device of the present invention.
As shown in the figure, it is identical that the permanent-magnet array of present embodiment is formed with embodiment 1, comprises center magnet 1 and limit magnet 2 and limit magnet 3.The used permanent magnet material trade mark is N38 in the present embodiment, the remanent magnetism Br=1.28T of material, HCJ iHc >=12Koe, maximum magnetic energy product (BH) max=37MGOe.Use identical permanent magnet material to sinter cross sectional shape into and be the square of the length of side as 40mm, length is the bar-shaped permanent magnet blocks of 50mm.Different with embodiment 1 is, 2 and 3 serves as to have rotated 5 ° in the middle of axially with its upper left limit and top right-hand side respectively.Fig. 82,3 turns over magnetic field intensity and the Gradient distribution on the 0-4cm line of magnet surface center behind the certain angle; Fig. 92,3 turns over behind the certain angle apart from the magnetic field gradient profile on the horizontal 1cm line in 3cm place, magnet surface center, can find out situation about comparing with embodiment 1, and magnetic field intensity and gradient all strengthen to some extent.
It is to be noted that though the angle of rotating in this instance is 5 °, to the surface curvature of different applications, this anglec of rotation can become, and the distribution shape of the magnetic field intensity of target area and gradient is constant.
In the present embodiment, it is identical that the permanent-magnet array is formed with embodiment 1, and the used permanent magnet material trade mark is N38 in the present embodiment, the remanent magnetism Br=1.28T of material, HCJ iHc >=12Koe, maximum magnetic energy product (BH) max=37MGOe.
And the difference of present embodiment is,
Like Fig. 4 and shown in Figure 5,Around magnet apparatus, add stainless steel casing frame 4, thereby strengthen its intensity.
In the present embodiment, it is identical that the permanent-magnet array is formed with embodiment 3, and the used permanent magnet material trade mark is N38 in the present embodiment, the remanent magnetism Br=1.28T of material, HCJ iHc >=12Koe, maximum magnetic energy product (BH) max=37MGOe.
And the difference of present embodiment is, has adopted the non-magnetic conduction support of adjustable-angle in the present embodiment, and is shown in figure 10; This support has comprised the rack I 4 and rack II 6 that is used for placing respectively permanent-magnet I and III; Also comprise the rack II 5 that is used to place permanent-magnet II simultaneously, be provided with the deck that is used for fixing permanent-magnet on each rack, hinged between the rack; Its connecting portion is positioned at the marginal position with the opposite side of work surface of permanent-magnet; In the present embodiment, being positioned on the dual-side with the opposite side of work surface of permanent-magnet of rack II offers fluting respectively, and the side that is connected of rack I and II is respectively arranged with boss structure; Through embedding boss structure in the fluting respectively; Adopt friction tight bolt arrangement that boss structure is hinged with fluting, thereby reach the work surface angle that to adjust as required between permanent-magnet I and permanent-magnet III and the permanent-magnet II, satisfy the needs under the different situations.
Certainly, the width of rack II and the size of deck can change, and can place different permanent-magnets as required on rack II.
As further improvement, after the magnet with both sides changeed up, wedge shape magnetic conduction substance (like ferromagnet) can be filled in the space between magnet, can further reduce the leakage field of inoperative side like this, thus the lateral magnetic field intensity of increase work.
Shown in figure 11, the difference of present embodiment and embodiment 4 is that the connected mode among the embodiment 5 is different,In the present embodiment; Being positioned on the dual-side with the opposite side of work surface of permanent-magnet of rack II offers the side groove respectively; Rather than be similar to the clip slot among the embodiment 4; And the side that is connected of rack I and II is respectively arranged with and the corresponding boss structure of side groove; Through adopting friction tight bolt arrangement that boss structure and side groove is hinged, thereby reach the work surface angle that to adjust as required between permanent-magnet I and permanent-magnet III and the permanent-magnet II, satisfy the needs under the different situations.
In the present embodiment, it is identical that the permanent-magnet array is formed with embodiment 3, and the used permanent magnet material trade mark is N38 in the present embodiment, the remanent magnetism Br=1.28T of material, HCJ iHc >=12Koe, maximum magnetic energy product (BH) max=37MGOe.
In the present embodiment; Extremely shown in Figure 15 like Figure 12; Comprise being used for placing the base 10 of permanent-magnet II and being used to be arranged on the base both sides and be respectively applied for the rotation rack 11 (this figure has omitted the rotation rack of opposite side) of placing permanent-magnet I and permanent-magnet III; The end of two sidewalls of rotation rack 11 comprises outward extending axle 12 separately, and axle 12 extends in opposite direction, and the end face of axle 12 is provided with the internal gear 121 of location usefulness; Be provided with a circular through hole 111 in the end of two sidewalls of base 10 and laterally run through this sidewall; The inwall of each through hole 111 is provided with a circular boss 112, and the lateral direction from annulus boss 112 toward base 10 arms on through hole 111 sidewalls also is formed with the chute of two L types, and this chute has comprised the guide channel 113 and the storage tank 114 that is positioned at through hole of the end face that passes through hole; This guide channel axially is provided with along through hole 111, and this storage tank 114 and guide channel are vertical each other and be communicated with.
For ease of fixing, shown in figure 11, this support has also comprised button spare 13; This button spare is three sections stair-stepping cylinders; It comprises the bigger head of diameter 131, sliding part 132 and locating rod 133 successively, and the sidewall protrusion of this sliding part is provided with guiding rib 134, and guiding rib adapts in the distribution of chute in through hole that be distributed in of sliding part 132; Form the gear 135 suitable at the end of locating rod 133, on locating rod, be arranged with a spring part 14 with internal gear 121.
Shown in figure 12, after rotation cooperated, the two side arms of this rotation rack was between the two side arms of base 10; It 12 can be contained in the through hole of base 10 rotationally, and button spare can insert outside the sidewall of base 10 in this through hole rotationally, its middle gear 135 pass this annulus boss around the hole; Match with the internal gear of the axle 12 of rotation on the rack; This guiding rib 134 can adopt sliding type to be contained in this chute, an end conflict annulus boss 112 of spring part 14, other end conflict sliding part 132; Head 131 is positioned at outside this through hole; Slide block be arranged in chute and can be along the chute shape in inside around circumferential slip or endwisely slip, the rotational angle that chute can limit button spare with move axially, make button spare be positioned at an axial adjustable position or an axial restraint position.
Rotary switch spare is the guide channel that guiding rib is aimed at chute, and when receiving the resilient force of spring part, the press section stretches out in base 10 1 segment distances; Gear separates with internal gear, and this moment, the user can rotate the angle of rack with respect to base, when rack is rotated to the angle of wanting; By press button spare guiding rib is accommodated to storage tank; Flexible member is in contraction state under the extruding of button spare and axle 12, this moment, gear was meshed with internal gear, carried out spacing to the rotation of internal gear; Thereby can the rotation rack be defined in support angle, satisfy instructions for use.
The common characteristic in the magnetic field that device produced of above-mentioned several kinds of embodiment is that the magnetic field intensity height and the cross direction profiles that produce in the side (work surface) of magnet apparatus are even, and along with the increase apart from the distance of magnet surface is the high gradient attenuation distribution; Opposite side at magnet apparatus then has only Distribution of Magnetic Field seldom, " monolateral " characteristic of Here it is Halbach magnet array.This unique characteristic makes the magnetic energy major part of permanent-magnet be distributed in this one side in the face of the targeting body, makes the magnetic energy utilization efficient of Halbach permanent-magnet be order of magnitude raising than common permanent-magnet.Magnet apparatus of the present invention can reach 9 teslas/more than the rice with magnet surface apart from the magnetic field gradient at place, the working region of 3cm, and common permanent-magnet has only 3-4 tesla/rice.Therefore, this magnet array can overcome the shortcoming of ordinary target to positioning magnet useful effect depth as shallow, for the occasion particularly suitable that requires at the magnetic and medicated microgranule of middle degree of depth spots localization.
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although with reference to preferred embodiment the present invention is specified, those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention; And not breaking away from the aim and the scope of present technique scheme, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (8)
1. adopt permanent-magnet to be used for magnetic and medicated Physical Target, it is characterized in that: may further comprise the steps to localized method:
Step 1: permanent-magnet I, II and the III of three regular shape are closely arranged by same direction successively; Wherein, It is identical with size and be the axis of symmetry left-right symmetric with the center line that is positioned at intermediary permanent-magnet II to be positioned at the shape of two permanent-magnet I, III of both sides, and along orientation, the direction of magnetization of three permanent-magnets is arranged by the Halbach array way; Be used for localized that one side of targeting, promptly work surface is continuous;
Step 2: will be used for magnetic and medicated targeting location according to the magnet apparatus that step 1 is processed apart from magnet surface 0-4cm.
2. employing permanent-magnet according to claim 1 is used for magnetic and medicated Physical Target to localized method; It is characterized in that: in step 1; In order to adapt to human body or other application the surface configuration of certain radian is arranged, two permanent-magnets on both sides can symmetricly rotate up 0 °-10 ° angle respectively.
3. employing permanent-magnet according to claim 1 and 2 is used for magnetic and medicated Physical Target to localized method, it is characterized in that: the permanent magnet material of permanent-magnet is neodymium iron boron, SmCo or ferrite
Employing permanent-magnet according to claim 3 is used for magnetic and medicated Physical Target to localized method, it is characterized in that: said permanent-magnet is square.
4. adopt permanent-magnet to be used for magnetic and medicated Physical Target to localized device; It is characterized in that: said device comprises that permanent-magnet I, permanent-magnet II and the permanent-magnet III of three regular shape and three permanent-magnets closely arrange by same direction successively; Wherein, It is identical with size and be the axis of symmetry left-right symmetric with the center line that is positioned at intermediary permanent-magnet II to be positioned at the shape of two permanent-magnet I, III of both sides, and along orientation, the direction of magnetization of three permanent-magnets is arranged by the Halbach array way; Be used for localized that one side of targeting, promptly work surface is continuous.
5. employing permanent-magnet according to claim 4 is used for magnetic and medicated Physical Target to localized device, it is characterized in that: the permanent magnet material of permanent-magnet is neodymium iron boron, SmCo or ferrite.
6. be used for magnetic and medicated Physical Target to localized device according to claim 5 or 6 described employing permanent-magnets, it is characterized in that: adopt the high strength glue bond between the said permanent-magnet.
7. be used for magnetic and medicated Physical Target to localized device according to claim 5 or 6 described employing permanent-magnets; It is characterized in that: said permanent-magnet adopts the non-magnetic conduction support of scalable to fix, and the non-magnetic conduction support of said scalable is used to regulate the angle between the work surface of work surface and permanent-magnet II of work surface and permanent-magnet III of permanent-magnet I.
8. be used for magnetic and medicated Physical Target to localized device according to claim 5 or 6 described employing permanent-magnets, it is characterized in that: said permanent-magnet is square.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103898516A CN102429857A (en) | 2011-11-30 | 2011-11-30 | Method and device for performing physical targeting positioning on magnetic medicine by using permanent magnets |
| PCT/CN2012/085471 WO2013079001A1 (en) | 2011-11-30 | 2012-11-28 | Method and device for physically targeting location of magnetic drug using permanent magnets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103898516A CN102429857A (en) | 2011-11-30 | 2011-11-30 | Method and device for performing physical targeting positioning on magnetic medicine by using permanent magnets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102429857A true CN102429857A (en) | 2012-05-02 |
Family
ID=45978447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103898516A Pending CN102429857A (en) | 2011-11-30 | 2011-11-30 | Method and device for performing physical targeting positioning on magnetic medicine by using permanent magnets |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN102429857A (en) |
| WO (1) | WO2013079001A1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102736043A (en) * | 2012-05-31 | 2012-10-17 | 重庆医科大学附属儿童医院 | Method and structure capable of forming conical and dome-shaped gradient magnetic field as well as targeting therapy equipment |
| CN103691048A (en) * | 2013-12-31 | 2014-04-02 | 山东科技大学 | Micro therapy apparatus acting on target cells |
| CN103971915A (en) * | 2014-04-21 | 2014-08-06 | 合肥晟辉磁性材料有限公司 | Manufacturing method of capsule endoscope control magnetic ball |
| CN104821674A (en) * | 2014-01-30 | 2015-08-05 | 住友重机械工业株式会社 | Permanent magnet motor, magnetization method and manufacturing method thereof |
| CN106503423A (en) * | 2016-09-29 | 2017-03-15 | 东南大学 | Based on the microvascular implantation seed magnetic targeted experiment in vitro device and method of infiltration |
| CN108744257A (en) * | 2018-03-30 | 2018-11-06 | 深圳海磁康科技有限责任公司 | Magnetic and medicated targeting method for congregating and magnet structure |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028551A (en) * | 2007-03-30 | 2007-09-05 | 天津大学 | Magnetic medicine guider |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431638C (en) * | 2002-12-11 | 2008-11-12 | 中国科学院电工研究所 | Medicine locating method for magnetic medicine target treatment |
-
2011
- 2011-11-30 CN CN2011103898516A patent/CN102429857A/en active Pending
-
2012
- 2012-11-28 WO PCT/CN2012/085471 patent/WO2013079001A1/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028551A (en) * | 2007-03-30 | 2007-09-05 | 天津大学 | Magnetic medicine guider |
Non-Patent Citations (4)
| Title |
|---|
| 《Advanced Materials Research》 20110816 he wei 《Application and Evaluation of Halbach-like Magnet Arrays to Magnetic Drug Targeting》 第320卷, * |
| HE WEI: "《Application and Evaluation of Halbach-like Magnet Arrays to Magnetic Drug Targeting》", 《ADVANCED MATERIALS RESEARCH》, vol. 320, 16 August 2011 (2011-08-16) * |
| 罗新等: "《磁流体在医药中的应用进展》", 《华 东 地 质 学 院 学 报》, vol. 26, no. 4, 31 December 2003 (2003-12-31), pages 399 * |
| 陈铀等: "《靶向输运磁性载药颗粒的研究进展》", 《数理医药学杂志》, vol. 21, no. 1, 31 December 2008 (2008-12-31) * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102736043A (en) * | 2012-05-31 | 2012-10-17 | 重庆医科大学附属儿童医院 | Method and structure capable of forming conical and dome-shaped gradient magnetic field as well as targeting therapy equipment |
| CN103691048A (en) * | 2013-12-31 | 2014-04-02 | 山东科技大学 | Micro therapy apparatus acting on target cells |
| CN103691048B (en) * | 2013-12-31 | 2015-09-23 | 山东科技大学 | A kind of micro device acting on target cell |
| CN104821674A (en) * | 2014-01-30 | 2015-08-05 | 住友重机械工业株式会社 | Permanent magnet motor, magnetization method and manufacturing method thereof |
| CN104821674B (en) * | 2014-01-30 | 2018-04-24 | 住友重机械工业株式会社 | Permanent magnet motor and its Magnitizing method, manufacture method |
| CN103971915A (en) * | 2014-04-21 | 2014-08-06 | 合肥晟辉磁性材料有限公司 | Manufacturing method of capsule endoscope control magnetic ball |
| CN106503423A (en) * | 2016-09-29 | 2017-03-15 | 东南大学 | Based on the microvascular implantation seed magnetic targeted experiment in vitro device and method of infiltration |
| CN108744257A (en) * | 2018-03-30 | 2018-11-06 | 深圳海磁康科技有限责任公司 | Magnetic and medicated targeting method for congregating and magnet structure |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013079001A1 (en) | 2013-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102429857A (en) | Method and device for performing physical targeting positioning on magnetic medicine by using permanent magnets | |
| Lübbe et al. | Clinical applications of magnetic drug targeting | |
| Li et al. | Magnetic nanoparticles for cancer theranostics: Advances and prospects | |
| Shen et al. | Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors | |
| Mahmoudi et al. | Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans | |
| Mu et al. | Nanoparticles for imaging and treatment of metastatic breast cancer | |
| Ma et al. | High intensity focused ultrasound-responsive and ultrastable cerasomal perfluorocarbon nanodroplets for alleviating tumor multidrug resistance and epithelial–mesenchymal transition | |
| Nguyen | Targeted nanoparticles for cancer therapy: promises and challenges | |
| Chertok et al. | Brain tumor targeting of magnetic nanoparticles for potential drug delivery: effect of administration route and magnetic field topography | |
| Yang et al. | Magnetic lymphatic targeting drug delivery system using carbon nanotubes | |
| Dobson | Magnetic nanoparticles for drug delivery | |
| Upton et al. | Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy | |
| Johannsen et al. | Evaluation of magnetic fluid hyperthermia in a standard rat model of prostate cancer | |
| Chatterjee et al. | Nanoparticle-mediated hyperthermia in cancer therapy | |
| Ting et al. | Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment | |
| Chua et al. | Emerging technologies for local cancer treatment | |
| KR100810606B1 (en) | Magnetic field applicator to heat magnetic or magnetizable substances or solids in biological tissue | |
| Häfeli et al. | Modeling of magnetic bandages for drug targeting: Button vs. Halbach arrays | |
| US20150126964A1 (en) | Drug delivery across the blood-brain barrier using magnetically heatable entities | |
| Tong et al. | Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages | |
| RU2015152033A (en) | TARGETED CORROLS MANIFESTING TUMOR TOXICITY AND INTENDED FOR MRI | |
| CA3235252A1 (en) | Magnetostrictive piezoelectric nanoassembly as cancer chemotherapeutic | |
| Seeney et al. | Magnetically vectored platforms for the targeted delivery of therapeutics to tumors: history and current status | |
| CN102736043B (en) | Method and structure capable of forming conical and dome-shaped gradient magnetic field as well as targeting therapy equipment | |
| ES2831378T3 (en) | Means and methods for targeted X-ray therapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: CHILDREN S HOSPITAL ATTACHED TO CHONGQING MEDICAL Effective date: 20120725 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20120725 Address after: 400044 Shapingba street, Shapingba District, Chongqing, No. 174 Applicant after: Chongqing University Co-applicant after: Children's Hospital Affiliated to Medical University of Chongqing Address before: 400044 Shapingba street, Shapingba District, Chongqing, No. 174 Applicant before: Chongqing University |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120502 |