CN102423396B - Composition used for treating rheumatoid arthritis - Google Patents
Composition used for treating rheumatoid arthritis Download PDFInfo
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- CN102423396B CN102423396B CN 201110445650 CN201110445650A CN102423396B CN 102423396 B CN102423396 B CN 102423396B CN 201110445650 CN201110445650 CN 201110445650 CN 201110445650 A CN201110445650 A CN 201110445650A CN 102423396 B CN102423396 B CN 102423396B
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Abstract
The invention relates to a composition used for treating rheumatoid arthritis. The composition is formed by mixing cornus officinalis, Chinese yam, gentiana macrophylla, Ligusticum wallichii, Japanese honeysuckle stems, and cortex moutan in a weight ratio of (15-35): (10-40):(5-20):(3-18):(6-20):(5-15). With the advantages of scientific and reasonable formula, definite therapeutic effect in rheumatoid arthritis treatment, and convenient administration, the composition of the invention can effectively treat rheumatoid arthritis and alleviate the symptoms of rheumatoid arthritis. Components of the composition are all pure traditional Chinese medicines, and have no obvious adverse reaction, high security as well as good patient compliance. Compared with other medicaments for treating rheumatoid arthritis, the composition provided in the invention has low price and convenience for wide application in communities and grass-roots hospitals, and can mitigate the economic burdens of patient families and the society, thus being more practical from the aspect of pharmacoeconomics.
Description
Technical field
The present invention relates to a kind of compositions that is used for the treatment of rheumatic arthritis.
Background technology
Rheumatic arthritis is common clinical, frequently-occurring disease, its cause of disease complexity, and pathological manifestations is various, and the touching difficulty of the course of disease more, even makes that the people is disabled, disability, is seriously endangering the healthy of the people.Existing antirheumatic, mainly contain NSAID (non-steroidal anti-inflammatory drug), adrenocortical steroid and immunosuppressant etc., and they mostly can only relief of symptoms, and can not stop the development of the state of an illness.
Chinese medicine belongs to the arthromyodynia category by this type of disease.Arthromyodynia is due to the exopathogen such as the human righteousness is not enough, wind and cold is damp and hot invasion and attack; Or interior living phlegm-damp, pyretic toxicity, blood stasis cause the retardance of passages through which vital energy circulates group, occur with limbs joint, myalgia weighing, numb swelling, joint stuffiness, even joint deformity, or involve the general name of the class disease that internal organs are feature.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions that is used for the treatment of rheumatic arthritis, uses said composition treatment rheumatic arthritis, can obtain obvious curative effects.
For solving the problems of the technologies described above, the invention provides a kind of compositions that is used for the treatment of rheumatic arthritis, press (15-35) by Fructus Corni, Rhizoma Dioscoreae, Radix Gentianae Macrophyllae, Rhizoma Chuanxiong, Caulis Lonicerae, Cortex Moutan: (10-40): (5-20): (3-18): (6-20): the weight ratio of (5-15) is mixed and is formed.
For can concise description for the purpose of problem, below to the compositions of rheumatic arthritis that is used for the treatment of of the present invention all referred to as this compositions.
The Therapeutic Principle of this combination treatment rheumatic arthritis is: replenishing YIN and removing heat, blood-activating and qi-promoting dredging collateral.
Urosolic acid, puckery, tepor, the nourishing kidney the liver benefiting.Fructus Corni total glycosides part can suppress to drench turn, Lymphokine killer cell (LAK cell) is induced and the generation of interleukin II.But Fructus Corni total glycosides part vitro inhibition mice and people's lymphocyte reaction, suppress inducing and rising in value of cytotoxic T cell.
Rhizoma Dioscoreae is in the research of C-II induced arthritis in rats, and Rhizoma Dioscoreae water extraction liquid can significantly suppress Cu
2+to the Denaturation of gamma Globulin, show to have antarthritic effect.
The Radix Gentianae Macrophyllae nature and flavor are hot, bitter, are slightly cold.Return stomach warp, Liver Channel, gallbladder meridian.Function: Eradicates rheumatism, relaxing muscles and tendons network, clearind deficient heat.Cure mainly: for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached.
The Rhizoma Chuanxiong acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Function with cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Caulis Lonicerae nature and flavor are sweet, cold.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, dispelling wind dredging collateral.For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, rheumatism pyretic arthralgia, redness and swelling of joints burning pain.
Cortex Moutan is cold in nature, bitter in the mouth, cool, be slightly cold.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; The rheumatism pyretic arthralgia.The easily release of capable inhibitive factor of acid α-naphthyl acetate esterase (ANAE) activity, lymphocyte percentage and leukocyte can significantly improve peripheral blood when low concentration (10-15ng/kg) in, thereby enhancing body cellular immune function; And can significantly improve the phagocytosis of peripheral blood neutrophil to staphylococcus aureus, and the enhancing body non-specific immunity.Cortex Moutan can make the diameter of capillary in microcirculation on the Mus mesentery, and in pipe, erythrocytic flow velocity speeds, and shows that Cortex Moutan is improved effect to local microcirculation.Cortex Moutan has potentiation to immune function of mice, can make mouse spleen exponential sum thymus index and lymhocyte transformation rate obviously improve.Cortex Moutan polysaccharide effective site PSM2h can directly promote the mouse boosting cell increment in vitro, and can work in coordination with the splenocyte proliferation that conA induces, Turnover of Mouse Peritoneal Macrophages is also had to activation, can strengthen the Turnover of Mouse Peritoneal Macrophages phagocytosis, and induce the synthetic nitric oxide prompting of macrophage PSM2h can strengthen the T lymphocyte function, and macrophage is had to activation.
The Therapeutic Principle of this compositions is: replenishing YIN and removing heat, invigorate blood circulation, promoting of the circulation of QI and removing the obstruction in the collaterals, urosolic acid, puckery, tepor, nourishing kidney the liver benefiting; Rhizoma Dioscoreae is sweet, flat, nourishing kidney strengthening the spleen and tonifying the lung, supplementing QI and nourishing YIN; Radix Gentianae Macrophyllae is bitter, hot, be slightly cold, wind-damp dispelling, reducing the asthenic fever; Rhizoma Chuanxiong is hot, warm, blood-activating and qi-promoting, wind-expelling pain-stopping; Caulis Lonicerae is sweet, cold, heat clearing away, dispelling toxins and dredging collaterals; Cortex Moutan is bitter, hot, is slightly cold, and clearing away heat and cooling blood, stasis-dispelling and pain-killing.Mainly gather altogether the merit of replenishing YIN and removing heat blood-activating and qi-promoting dredging collateral.
This compositions has prescription science, rationally, determined curative effect, and taking convenience, the advantage for the treatment of rheumatic arthritis determined curative effect, can effectively treat rheumatic arthritis, alleviate the symptom of rheumatic arthritis.This compositions component is all pure Chinese medicine, and without obvious adverse reaction, safe, patient compliance is better.With respect to the medicine of other treatment treatment rheumatic arthritis, this compositions is cheap, is convenient to community and basic hospital is widely used, and can alleviate patient family and social financial burden, from the pharmacoeconomics aspect, has more practicality.
Each component of this compositions all can be buied on market.
Take and can be used for the treatment of rheumatic arthritis after this compositions water is fried.
For further illustrating the effect of this compositions, the existing case with treatment is explained.
The diagnostic criteria of rheumatic arthritis:
1, medical history: before sick, the hemolytic streptococcal infection history is arranged more.
2, symptom: the large joint of extremity (wrist, elbow, shoulder, ankle, knee joint, hip) migration is altered pain or is swollen and ache.
3, sign: the joint of getting involved is red, swollen, hot, pain or swell and ache, and movable function is limited, and some cases can have low grade fever, erythema nodosum, erythema iris or heart change etc. concurrently.
4, lab testing: active stage ESR generally speeds more, and how normal nonmobile phase is.Active stage ASO many positive (more than 1:600u), as ASO negative patient (1:400u is following), must be shown in erythema iris or erythema nodosa are arranged, otherwise can not be diagnosed as rheumatic arthritis.
5, x-ray inspection: the rarely seen soft tissue swelling in the joint of getting involved, without sclerotin change.
The rheumatic arthritis criterion of cure: joint symptom, sign disappear, and laboratory inspection ESR and ASO are normal.
Rheumatic arthritis is alleviated standard: joint symptom, sign take a turn for the better, and laboratory inspection ESR and ASO are normal.
Case 125 examples of making a definite diagnosis through above-mentioned diagnostic criteria, adopt this combination treatment, within 15 days, is a course for the treatment of, after treating 3 courses for the treatment of, cures altogether 97 examples, alleviates 26 examples, invalid 2 examples, and total effective rate is 98.4%.
In sum, use this combination treatment rheumatic arthritis, determined curative effect.
The specific embodiment
Further illustrate the present invention below by embodiment.
Embodiment 1: be used for the treatment of the compositions of rheumatic arthritis, be comprised of Fructus Corni 25g, Rhizoma Dioscoreae 30g, Radix Gentianae Macrophyllae 12g, Rhizoma Chuanxiong 10g, Caulis Lonicerae 15g, Cortex Moutan 10g.After the Chinese medicine of above-mentioned weight portion is carried out to dedusting, drying, pulverizing, be distributed into pouch, take every day 2-3 times, each 8-10g, warm boiled water gets final product.
Embodiment 2: be used for the treatment of the compositions of rheumatic arthritis, be comprised of Fructus Corni 15g, Rhizoma Dioscoreae 10g, Radix Gentianae Macrophyllae 5g, Rhizoma Chuanxiong 3g, Caulis Lonicerae 6g, Cortex Moutan 5g.After the Chinese medicine of above-mentioned weight portion is carried out to dedusting, drying, pulverizing, be distributed into pouch, take every day 2-3 times, each 8-10g, warm boiled water gets final product.
Embodiment 3: be used for the treatment of the compositions of rheumatic arthritis, be comprised of Fructus Corni 35g, Rhizoma Dioscoreae 40g, Radix Gentianae Macrophyllae 20g, Rhizoma Chuanxiong 18g, Caulis Lonicerae 20g, Cortex Moutan 15g.After the Chinese medicine of above-mentioned weight portion is carried out to dedusting, drying, pulverizing, be distributed into pouch, take every day 2-3 times, each 8-10g, warm boiled water gets final product.
This compositions can be carried out according to the state of an illness increase and decrease of each component and weight portion in actual applications.
Above-described is only one embodiment of the present invention.It should be pointed out that for the person of ordinary skill of the art, under the premise without departing from the principles of the invention, can also make apparent some conversion or substitute and remodeling, these also should be considered as belonging to protection scope of the present invention.
Claims (1)
1. the compositions that is used for the treatment of rheumatic arthritis, mixed and form by the weight ratio of 25:30:12:10:15:10 by Fructus Corni, Rhizoma Dioscoreae, Radix Gentianae Macrophyllae, Rhizoma Chuanxiong, Caulis Lonicerae, Cortex Moutan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110445650 CN102423396B (en) | 2011-12-28 | 2011-12-28 | Composition used for treating rheumatoid arthritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110445650 CN102423396B (en) | 2011-12-28 | 2011-12-28 | Composition used for treating rheumatoid arthritis |
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| Publication Number | Publication Date |
|---|---|
| CN102423396A CN102423396A (en) | 2012-04-25 |
| CN102423396B true CN102423396B (en) | 2013-12-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110445650 Expired - Fee Related CN102423396B (en) | 2011-12-28 | 2011-12-28 | Composition used for treating rheumatoid arthritis |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1485063A (en) * | 2002-09-26 | 2004-03-31 | 纪文华 | Chinese traditional medicine formulation for rheumatism and its orthopaedic disease |
| CN1323154C (en) * | 2005-04-19 | 2007-06-27 | 石泽生 | Longevity medicinal wine and preparation method thereof |
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| CN102423396A (en) | 2012-04-25 |
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Granted publication date: 20131218 Termination date: 20211228 |
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| CF01 | Termination of patent right due to non-payment of annual fee |