CN102417506A - 一种抗病毒药物恩替卡韦的制备方法 - Google Patents
一种抗病毒药物恩替卡韦的制备方法 Download PDFInfo
- Publication number
- CN102417506A CN102417506A CN2010102944495A CN201010294449A CN102417506A CN 102417506 A CN102417506 A CN 102417506A CN 2010102944495 A CN2010102944495 A CN 2010102944495A CN 201010294449 A CN201010294449 A CN 201010294449A CN 102417506 A CN102417506 A CN 102417506A
- Authority
- CN
- China
- Prior art keywords
- compound
- promptly
- entecavir
- compounds
- rare gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SSMCWABRSNVQHT-GVAUOCQISA-N C=C([C@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)[C@H](C1)O)[C@@H]1O Chemical compound C=C([C@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)[C@H](C1)O)[C@@H]1O SSMCWABRSNVQHT-GVAUOCQISA-N 0.000 description 1
- PZWAUBZYSHDQRF-MYKRZTLLSA-N C=C([C@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)[C@H](C1)O)[C@H]1[n]1c2nc(N)cc(Cl)c2nc1 Chemical compound C=C([C@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)[C@H](C1)O)[C@H]1[n]1c2nc(N)cc(Cl)c2nc1 PZWAUBZYSHDQRF-MYKRZTLLSA-N 0.000 description 1
- CWSMTGSMKMNOOX-DWYQZRHDSA-N CC(C)(O[C@@H]1C2)O[C@H]1OC2C(CO)O Chemical compound CC(C)(O[C@@H]1C2)O[C@H]1OC2C(CO)O CWSMTGSMKMNOOX-DWYQZRHDSA-N 0.000 description 1
- KIMHHCNOAGUECF-BIIVOSGPSA-N COC[C@H]([C@H](C[C@H]1O)N=O)C1=C Chemical compound COC[C@H]([C@H](C[C@H]1O)N=O)C1=C KIMHHCNOAGUECF-BIIVOSGPSA-N 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
原料 | 投料量 |
化合物XII | 55.4g |
3N HCl | 100ml |
MeOH | 400ml |
THF | 400ml |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010294449.5A CN102417506B (zh) | 2010-09-27 | 2010-09-27 | 一种抗病毒药物恩替卡韦的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010294449.5A CN102417506B (zh) | 2010-09-27 | 2010-09-27 | 一种抗病毒药物恩替卡韦的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102417506A true CN102417506A (zh) | 2012-04-18 |
CN102417506B CN102417506B (zh) | 2016-04-06 |
Family
ID=45942169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201010294449.5A Active CN102417506B (zh) | 2010-09-27 | 2010-09-27 | 一种抗病毒药物恩替卡韦的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102417506B (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103387587A (zh) * | 2013-01-14 | 2013-11-13 | 重庆康施恩化工有限公司 | 恩替卡韦中间体及其制备方法 |
CN103664943A (zh) * | 2012-09-06 | 2014-03-26 | 天津长森药业有限公司 | 嘌呤衍生物的制备方法及其中间体和应用 |
WO2015051900A1 (en) * | 2013-10-08 | 2015-04-16 | Pharmathen S.A. | Process for the preparation of entecavir through novel intermediates |
CN105001223A (zh) * | 2015-06-30 | 2015-10-28 | 湖南三清药业有限公司 | 一种恩替卡韦晶体化合物及其胶囊制剂 |
CN111434663A (zh) * | 2019-01-14 | 2020-07-21 | 刘沛 | 一种恩替卡韦中间体及其合成方法和恩替卡韦的合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005118585A1 (en) * | 2004-06-04 | 2005-12-15 | Bristol-Myers Squibb Company | Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation |
CN1861602A (zh) * | 2005-05-13 | 2006-11-15 | 上海仲夏化学有限公司 | 恩替卡韦的制备方法 |
-
2010
- 2010-09-27 CN CN201010294449.5A patent/CN102417506B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005118585A1 (en) * | 2004-06-04 | 2005-12-15 | Bristol-Myers Squibb Company | Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation |
CN1861602A (zh) * | 2005-05-13 | 2006-11-15 | 上海仲夏化学有限公司 | 恩替卡韦的制备方法 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103664943A (zh) * | 2012-09-06 | 2014-03-26 | 天津长森药业有限公司 | 嘌呤衍生物的制备方法及其中间体和应用 |
CN103664943B (zh) * | 2012-09-06 | 2015-12-02 | 天津长森药业有限公司 | 嘌呤衍生物的制备方法及其中间体和应用 |
CN103387587A (zh) * | 2013-01-14 | 2013-11-13 | 重庆康施恩化工有限公司 | 恩替卡韦中间体及其制备方法 |
CN103387587B (zh) * | 2013-01-14 | 2015-12-09 | 重庆康施恩化工有限公司 | 恩替卡韦中间体及其制备方法 |
WO2015051900A1 (en) * | 2013-10-08 | 2015-04-16 | Pharmathen S.A. | Process for the preparation of entecavir through novel intermediates |
CN105001223A (zh) * | 2015-06-30 | 2015-10-28 | 湖南三清药业有限公司 | 一种恩替卡韦晶体化合物及其胶囊制剂 |
CN105001223B (zh) * | 2015-06-30 | 2016-08-17 | 湖南三清药业有限公司 | 一种恩替卡韦晶体化合物及其胶囊制剂 |
CN111434663A (zh) * | 2019-01-14 | 2020-07-21 | 刘沛 | 一种恩替卡韦中间体及其合成方法和恩替卡韦的合成方法 |
CN111434663B (zh) * | 2019-01-14 | 2022-05-10 | 刘沛 | 一种恩替卡韦中间体及其合成方法和恩替卡韦的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
CN102417506B (zh) | 2016-04-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102417506A (zh) | 一种抗病毒药物恩替卡韦的制备方法 | |
EA029039B1 (ru) | Способ получения лекарственного средства с использованием хиральных 8-(3-аминопиперидин-1-ил)ксантинов | |
CN101962379B (zh) | 一种磺酰基异喹啉衍生物的精制方法 | |
CN101210015B (zh) | 一种乙肝治疗药物恩替卡韦的制备方法 | |
CN102933585B (zh) | Carba-核苷合成及其中使用的新型中间体 | |
CN106146593A (zh) | 一种制备去氧胆酸的方法 | |
WO2021098847A1 (zh) | 一种克林霉素磷酸酯的纯化方法 | |
CN111943937A (zh) | 三苯基坎地沙坦的合成方法 | |
CN103319548A (zh) | 一种蔗糖-6-乙酸酯的提纯方法 | |
CN101531660B (zh) | 一种恩替卡韦一水合物的工业化生产工艺 | |
CN114380877B (zh) | 一种2’-脱氧-2’-β-氟-4’-叠氮胞苷的制备方法 | |
CN101492482B (zh) | 一种工业化生产盐酸吉西他滨的合成工艺 | |
CN108148061B (zh) | 恩替卡韦的工业化制备方法 | |
CN106699812A (zh) | 替诺福韦前药的制备和纯化方法 | |
CN104311518A (zh) | 一种6-甲基灯盏乙素苷元的制备方法 | |
CN112608313A (zh) | 一种三乙酰更昔洛韦生产母液析出物的处理方法 | |
CN101805339A (zh) | 一种新方法的恩替卡韦化合物 | |
CN104119346A (zh) | 一种培美曲塞二钠的制备方法 | |
CN101628927B (zh) | 以1,3,5-三-O-苯甲酰基-α-D-呋喃核糖为原料立体选择性制备β-二氟胞苷盐酸盐的方法 | |
CN101646685B (zh) | 合成ib-meca的方法 | |
CN103739603B (zh) | 一种恩替卡韦的制备方法 | |
CN104530130B (zh) | 一种制备阿德福韦酯的方法 | |
CN101585837B (zh) | 一种从苦参总碱中分离苦参碱和氧化苦参碱的方法 | |
WO2024082156A1 (zh) | 一种利用醇水碱解体系制备三氯蔗糖粗品的方法 | |
CN112979724B (zh) | 一种吉西他滨中间体的母液回收方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
CB02 | Change of applicant information |
Address after: Hangzhou City, Zhejiang province Binjiang District 310052 shore road 1180 China Science and Technology Park 2 Building 4 floor West Applicant after: HANGZHOU SHARPLY PHARM R&D INSTIT. Co.,Ltd. Applicant after: HAINAN POLY PHARM. Co.,Ltd. Applicant after: ZHEJIANG POLY PHARMACEUTICAL Co.,Ltd. Address before: Hangzhou City, Zhejiang province Binjiang District 310052 shore road 1180 China Science and Technology Park 2 Building 4 floor West Applicant before: HANGZHOU SHARPLY PHARM R&D INSTIT. Co.,Ltd. Applicant before: Hainan Poly Pharm Co.,Ltd. Applicant before: Zhejiang Ruida Pharm Co.,Ltd. |
|
COR | Change of bibliographic data | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20230116 Address after: 571127 Guilin Ocean Economic Development Zone, Meilan District, Haikou City, Hainan Province Patentee after: HAINAN POLY PHARM. Co.,Ltd. Patentee after: ZHEJIANG POLY PHARMACEUTICAL Co.,Ltd. Address before: West side of 4/F, Building 2, Huaye Science Park, No. 1180 Bin'an Road, Binjiang District, Hangzhou, Zhejiang 310052 Patentee before: HANGZHOU SHARPLY PHARM R&D INSTIT. Co.,Ltd. Patentee before: HAINAN POLY PHARM. Co.,Ltd. Patentee before: ZHEJIANG POLY PHARMACEUTICAL Co.,Ltd. |
|
DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Xu Zhao Document name: Notification of Conformity |