CN102415397A - Synergia insecticide composition containing dinotefuran and chlorfluazuron and application thereof - Google Patents
Synergia insecticide composition containing dinotefuran and chlorfluazuron and application thereof Download PDFInfo
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- CN102415397A CN102415397A CN2010102998353A CN201010299835A CN102415397A CN 102415397 A CN102415397 A CN 102415397A CN 2010102998353 A CN2010102998353 A CN 2010102998353A CN 201010299835 A CN201010299835 A CN 201010299835A CN 102415397 A CN102415397 A CN 102415397A
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- fluorine pyridine
- pyridine urea
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Abstract
The invention discloses a synergia insecticide composition containing dinotefuran and chlorfluazuron and an application thereof. The synergia insecticide composition uses the dinotefuran and the chlorfluazuron as major effective ingredients, wherein the weight ratio of the dinotefuran to the chlorfluazuron is (0.1 to 80)/(0.5 to 80). The insecticide composition is used for preventing and treating various kinds of pests such as lepidoptera pests, homoptera pests, hymenoptera pests, coleoptera pests and the like and has the effects of prevention and treatment range expansion and effect enhancement, and in addition, the medication cost can be reduced.
Description
Technical field
The invention belongs to pesticide field, being specifically related to a kind of is the Pesticidal combination and the application thereof of main active ingredient with MTI-446 and fluorine pyridine urea.
Background technology
MTI-446 (dinotefuran), chemical name: 1-methyl-2-nitro-3-(tetrahydrochysene-3-furfuryl) guanidine, white crystal, 107.5 ℃ of fusing points, 94.5～101.5 ℃ of industrial goods, vapour pressure＜1.7 * 10-6pa (30 ℃), density 1.33 (25 ℃).Solvability is water 40g/L, is insoluble in cyclohexane, solvent wet goods organic solvent.Structural formula is:
MTI-446 is fool proof to mammal, and its acute oral LD50 is male rat 2450mg/kg, female rats 2275mg/kg; Male mice 2840mg/kg, female mice 2000mg/kg.To rat acute through skin LD50＞2000mg/kg (female, hero).No teratogenesis, carcinogenic and mutagenicity.MTI-446 is also fool proof to aquatile.The ichthyotoxin test shows that MTI-446 is to carp nm (48h)＞1000mg/L, to water flea＞1000mg/L; Equally, MTI-446 is also very low to birds toxicity, and through the honeybee test is learnt, MTI-446 is to honeybee safety to quail acute oral LD50＞1000mg/kg., and do not influence honeybee producting honey.This medicament insecticidal spectrum is wide, has remarkable interior suction osmosis, and has promptly shown very high insecticidal activity at very low dosage.This medicament is fool proof to mammal, birds and aquatile, and crop is not had poisoning, can be used for numerous crops such as paddy rice, fruit tree, vegetables.
Fluorine pyridine urea (Chlorfluazuron), chemical name: 1-(3,5-two chloro-4-(3-chloro-5-trifluoromethyl-2-pyridine oxygen base) phenyl)-3-(2, the 6-difluoro benzoyl) urea, structural formula is:
Fluorine pyridine urea is a kind of application growth regulator comparatively widely, tool stomach toxicity, action of contace poison.The mechanism of action is to suppress chitin to synthesize, and hinders insect and normally casts off a skin, and makes the developmental deformity of hatching, larval molting and the pupa of ovum, and adult eclosion is obstructed.Drug effect is high, and speed of action is slower, and to multiple lepidoptera pest, and orthoptera, coleoptera, Hymenoptera, diptera isoreactivity are high, but invalid to aphid, leafhopper, plant hopper.Fluorine pyridine urea is to mammiferous acute through skin LD
50＞8500mg/kg, acute oral LD
50＞1000mg/kg.
Often there is defective in the insecticide variety that contains single component in the agricultural chemicals control of insect: use continuously to be easy to generate pesticide resistance, insecticidal spectrum is narrow, can not comprehensive protection be provided for crop, and peasant's drug cost is high.The inventor is through discovering, the combination through two kinds or various active composition is the above-mentioned shortcoming of customer service to a certain extent.
Summary of the invention
The purpose of this invention is to provide a kind of Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea; Said composition can be used for preventing and treating the various agricultural insect; For example in control paddy rice rice leaf roller, striped rice borer, paddy stem borer, pink rice borer, rice plant skipper; Can prevent that again rice fulgorid, rice silk worm are first-class, can reach the effect that a drug is prevented and treated dissimilar insects.
Another object of the present invention provides the Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea and prevents and treats the application in the insecticidal materials of one or more insects in resistance Lepidoptera, Homoptera, Hymenoptera or the coleoptera in preparation.
The present invention adopts following technical scheme:
A kind of Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea; It is main active ingredient with MTI-446 and fluorine pyridine urea, and wherein, the weight ratio of MTI-446 and fluorine pyridine urea is 0.1～80: 0.5～80; Be preferably 1～60: 1～70, further be preferably 1～30: 1～30.The effective ingredient of above-mentioned desinsection combination is present in the composition with the synergy effective dose.
At the Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea of the present invention, MTI-446 and the two weight percentage in this Synergistic insecticidal compositions of fluorine pyridine urea are 2%～80%, are preferably 8%～60%, and optimum is 20%～40%.
The above-mentioned Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea is that main active ingredient (active component) and insecticides adjuvant, excipients are mixed with any one formulation that allows on the agricultural chemicals with MTI-446 and fluorine pyridine urea.The preferred pulvis of formulation, wetting powder, suspending agent, missible oil and water dispersion granule.
Said auxiliary agent can adopt calcium dodecyl benzene sulfonate, APES, polyoxyethylene polyoxy third rare block compound (like farming breast 33
#), conventional auxiliary agent such as NPE, excipient comprises cyclohexanone, xylol, solvent naphtha, water, antifreezing agent (like propane diols), deionized water etc.Above auxiliary agent, excipient and other agricultural go up known auxiliary material can singly use or mix usefulness.
Synergistic insecticidal compositions antagonism lepidoptera pest of the present invention has significant preventive effect, and the various pests that especially is easy to generate resistance for rice leaf roller, striped rice borer, paddy stem borer, pink rice borer, rice plant skipper etc. has good preventive effect; And suppress insect the pesticide resistance of single preparation (MTI-446 or fluorine pyridine urea) is produced and can prevent and treat simultaneously homoptera pest such as rice fulgorid, aleyrodid, leafhopper etc., reach the effect that a medicine is controlled more.The above-mentioned Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea can be applicable to prepare the insecticidal materials of one or more insects in control Lepidoptera, Homoptera, Hymenoptera or the coleoptera, is particularly useful for preparing the insecticidal materials of control rice fulgorid or snout moth's larva.
Pesticidal combination of the present invention compared with prior art; Produce following beneficial effect: the insecticidal materials that said composition prepares is used to prevent and treat Lepidoptera, Homoptera, Hymenoptera or coleopteran pest; Obvious synergistic function is arranged; And a medicine is controlled more, and a dispenser can prevent and treat various pests simultaneously, reduces control recruitment cost; Alternative high-toxic pesticide, and reduce the field dosage significantly, effectively reduce environmental pollution and residue of pesticide; Have concurrently quick-acting and long-acting; Compare with the agent of MTI-446 list, produce and the use cost reduction; Suppress the resistance enhancing of insect to agricultural chemicals.
Embodiment
Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.Pass through indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage earlier; On this basis, carry out field trial again.
Embodiment 1:
Taking by weighing MTI-446, fluorine pyridine urea, to adopt the conventional formulation method to be mixed with main active ingredient weight percentage by different proportion be 30% MTI-446 5 percent of hexaflumuron emulsifiable concentrate.Concrete ratio is seen table 1.The contrast medicament is respectively 30% MTI-446 missible oil and 30% 5 percent of hexaflumuron emulsifiable concentrate.
Adopt feed to add malicious method and measure MTI-446 and fluorine pyridine urea and composite sample thereof virulence rice-stem borer, every processing repetition 3 times, every concentration is handled 30, uses LC
50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:
Table 1 MTI-446, fluorine pyridine urea and composite sample thereof are to toxicity test and the co-toxicity coefficient of rice-stem borer
Data show in the table, and MTI-446 and the fluorine pyridine urea back that is mixed has synergistic effect to rice-stem borer, and four listed in table proportioning co-toxicity coefficients are all much larger than 120, so MTI-446 and fluorine pyridine urea are mixed and have significant synergies.The synergistic effect maximum that wherein when the ratio of fluorine pyridine urea and MTI-446 is 5: 1, is mixed and kills rice-stem borer, co-toxicity coefficient is 200.12.
Embodiment 2:
Taking by weighing MTI-446, fluorine pyridine urea, to adopt the conventional formulation method to be mixed with main active ingredient weight percentage by different proportion be 30% MTI-446 5 percent of hexaflumuron emulsifiable concentrate.The contrast medicament is respectively 30% MTI-446 missible oil and 30% 5 percent of hexaflumuron emulsifiable concentrate, and concrete ratio is seen table 2.
Adopt rice stem infusion process to measure MTI-446 and fluorine pyridine urea and composite sample thereof the virulence to the paddy rice brown planthopper, LC is used in every processing repetition 3 times
50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:
Table 2 MTI-446, fluorine pyridine urea and composite sample thereof are to toxicity test and the co-toxicity coefficient of paddy rice brown planthopper
Data show in the table, and MTI-446 and the fluorine pyridine urea back that is mixed has synergistic effect to brown planthopper, and four listed in table proportioning co-toxicity coefficients are all much larger than 120, so MTI-446 and fluorine pyridine urea are mixed and have significant synergies.The synergistic effect maximum that wherein when the ratio of MTI-446 and fluorine pyridine urea is 1: 10, is mixed and kills paddy rice paddy rice brown planthopper, co-toxicity coefficient is 220.14.
Embodiment 3:
Take by weighing 5g MTI-446,20g fluorine pyridine urea, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, xylol to 100g; Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 25% MTI-446 5 percent of hexaflumuron emulsifiable concentrate.
Adopt 3 of embodiment to join the field trial that sample carries out control in field paddy rice brown planthopper, the contrast medicament is 25% MTI-446 WP and 25% fluorine pyridine urea EC, and concrete consumption is seen table 3; Every mu of water consumption is 30kg, looks into 7 days behind the medicine 3 days; 14 days, 28 days results, result of the test is seen table 3:
Table 3 instance 3 samples are to the field test results of paddy rice brown planthopper
Can find out that by table 33 pairs of paddy rice brown planthoppers of instance have fabulous quick-acting, and the lasting period is more intense, performance is the outstanding medicament of control paddy rice brown planthopper well in the field.
Embodiment 4:
Adopt 3 of embodiment to join the field trial that sample carries out the control in field rice-stem borer, the contrast medicament is 25% MTI-446 WP (wetting powder) and 25% fluorine pyridine urea EC (missible oil), and concrete consumption is seen table 3; Every mu of water consumption is 30kg; Looked into behind the medicine 3 days, 7 days, 14 days; 28 days results, result of the test is seen table 4:
Table 4 instance 3 samples are to the field test results of rice-stem borer
Can find out that by table 4 instance 3 samples have fabulous effect to rice-stem borer, and the lasting period is long, performance is the outstanding medicament that prevents striped rice borer well in the field.
Measure through indoor synergism test and to show: water rice hopper and striped rice borer are all had significant synergistic insecticidal action by composite dose of MTI-446 and fluorine pyridine urea; Field control effectiveness test equally also shows the composite dose of effect that the insecticidal effect of water rice hopper and striped rice borer all is significantly higher than corresponding single agent agricultural chemicals that the present invention is all.
Embodiment 5:
Take by weighing 0.2g MTI-446,20g fluorine pyridine urea, sodium lignin sulfonate 10g, Negel 2g, add to 100g with kaolin; Above raw material is mixed in micronizer, form main active ingredient weight percentage and be 20.2% MTI-446 fluorine pyridine urea wetting powder.
Embodiment 6:
Take by weighing 78g MTI-446,0.5g fluorine pyridine urea, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 6g, xylol and add to 100g; Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 78.5% MTI-446 5 percent of hexaflumuron emulsifiable concentrate.
Embodiment 7:
Take by weighing 2g MTI-446,10g fluorine pyridine urea, phenethyl phenol polyethenoxy ether phosphate 3g, farming breast 33
#(alkylaryl polyoxyethylene polyoxypropylene ether) 2g, APES 1g, vegetable oil 13g adds water to 100g.Above raw material is dropped into the mixing kettle high speed by the method for routine preparation aqueous emulsion mix, form main active ingredient weight percentage and be 12% MTI-446 fluorine pyridine urea aqueous emulsion.
Embodiment 8:
Take by weighing 10g MTI-446,30g fluorine pyridine urea, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, farming breast 33
#(alkylaryl polyoxyethylene polyoxypropylene ether) 2g, APES 1g, isopropyl alcohol 10g adds water to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation microemulsion mix, form main active ingredient weight percentage and be 40% MTI-446 fluorine pyridine urea microemulsion.
Embodiment 9:
Take by weighing 4g MTI-446,4g fluorine pyridine urea, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 3g, xylol to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 8% MTI-446 5 percent of hexaflumuron emulsifiable concentrate.
Embodiment 10:
Take by weighing 3g MTI-446,30g fluorine pyridine urea, sodium lignin sulfonate 3g; Polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.2g, ethylene glycol 10g; Silica ethane 0.1g; Aluminium-magnesium silicate 0.5g, water is supplied 100g, and the main active ingredient weight percentage of formation is 33% MTI-446 fluorine pyridine urea suspending agent under the effect of sand mill.
Embodiment 11:
Take by weighing 5g MTI-446,60g fluorine pyridine urea, APES 14g, phenethyl phenol polyethenoxy ether 15g, xylol to 100g; Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 65% MTI-446 5 percent of hexaflumuron emulsifiable concentrate.
Embodiment 12:
Take by weighing 45g MTI-446,5g fluorine pyridine urea, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g; Polyvinyl alcohol 5g; Borax 2g; Kaolin 28g, it is 50% MTI-446 fluorine pyridine urea water dispersible granules that above raw material is formed main active ingredient weight percentage by the method for water dispersion granule.
Embodiment 13:
Take by weighing 25g MTI-446,25g fluorine pyridine urea, APES 14g, phenethyl phenol polyethenoxy ether 15g, xylol to 100g; Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 50% MTI-446 5 percent of hexaflumuron emulsifiable concentrate.
Claims (9)
1. a Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea is characterized in that this Synergistic insecticidal compositions is main active ingredient with MTI-446 and fluorine pyridine urea, and wherein, the weight ratio of MTI-446 and fluorine pyridine urea is 0.1～80: 0.5～80.
2. the Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea according to claim 1 is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of fluorine pyridine urea are 1～60: 1～70.
3. the Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea according to claim 2 is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of fluorine pyridine urea are 1～30: 1～30.
4. the Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea according to claim 1 is characterized in that MTI-446 and the two weight percentage in this Synergistic insecticidal compositions of fluorine pyridine urea are 2%～80%.
5. the Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea according to claim 4 is characterized in that MTI-446 and the two weight percentage in this Synergistic insecticidal compositions of fluorine pyridine urea are 8%～60%.
6. the Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea according to claim 1 is characterized in that this Synergistic insecticidal compositions is that main active ingredient and insecticides adjuvant, excipients are mixed with any one formulation that allows on the agricultural chemicals with MTI-446 and fluorine pyridine urea.
7. the Synergistic insecticidal compositions that contains MTI-446 and fluorine pyridine urea according to claim 6 is characterized in that said formulation is missible oil, wetting powder, microemulsion, aqueous emulsion, suspending agent or water dispersion granule.
8. the described application of Synergistic insecticidal compositions in preparing the insecticidal materials of preventing and treating one or more insects in Lepidoptera, Homoptera, Hymenoptera or the coleoptera that contains MTI-446 and fluorine pyridine urea of claim 1.
9. application according to claim 8 is characterized in that containing the application of Synergistic insecticidal compositions in the insecticidal materials of preparation control rice fulgorid or snout moth's larva of MTI-446 and fluorine pyridine urea.
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| CN 201010299835 CN102415397B (en) | 2010-09-28 | 2010-09-28 | Synergia insecticide composition containing dinotefuran and chlorfluazuron and application thereof |
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| CN 201010299835 CN102415397B (en) | 2010-09-28 | 2010-09-28 | Synergia insecticide composition containing dinotefuran and chlorfluazuron and application thereof |
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| CN102415397A true CN102415397A (en) | 2012-04-18 |
| CN102415397B CN102415397B (en) | 2013-12-25 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54125677A (en) * | 1978-03-17 | 1979-09-29 | Ishihara Sangyo Kaisha Ltd | N-benzoyl-n'-pyridyloxyphenylurea compound,its preparation,and insecticide containing the same |
| JPS5764604A (en) * | 1980-10-08 | 1982-04-19 | Ishihara Sangyo Kaisha Ltd | Exterminating method of fly |
| CN1112556A (en) * | 1993-10-26 | 1995-11-29 | 三井东压化学株式会社 | Furanyl insecticide |
| CN1889842A (en) * | 2003-12-05 | 2007-01-03 | 拜尔农作物科学股份公司 | Synergistic insecticide mixtures |
-
2010
- 2010-09-28 CN CN 201010299835 patent/CN102415397B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54125677A (en) * | 1978-03-17 | 1979-09-29 | Ishihara Sangyo Kaisha Ltd | N-benzoyl-n'-pyridyloxyphenylurea compound,its preparation,and insecticide containing the same |
| JPS5764604A (en) * | 1980-10-08 | 1982-04-19 | Ishihara Sangyo Kaisha Ltd | Exterminating method of fly |
| CN1112556A (en) * | 1993-10-26 | 1995-11-29 | 三井东压化学株式会社 | Furanyl insecticide |
| CN1889842A (en) * | 2003-12-05 | 2007-01-03 | 拜尔农作物科学股份公司 | Synergistic insecticide mixtures |
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