CN102408094A - Preparation method for highly repetitive surface enhanced Raman spectrum (SERS) active substrate - Google Patents
Preparation method for highly repetitive surface enhanced Raman spectrum (SERS) active substrate Download PDFInfo
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- CN102408094A CN102408094A CN2011103558961A CN201110355896A CN102408094A CN 102408094 A CN102408094 A CN 102408094A CN 2011103558961 A CN2011103558961 A CN 2011103558961A CN 201110355896 A CN201110355896 A CN 201110355896A CN 102408094 A CN102408094 A CN 102408094A
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Abstract
The invention relates to a surface enhanced Raman spectrum technology or the technical field of chemical analysis and provides a preparation method for a highly repetitive surface enhanced Raman spectrum (SERS) active substrate. The preparation method comprises the following steps: (1) preparing a precious metal nano particle colloid; (2) obtaining a high-concentrated metal nano particle; (3) synthesizing metal nano particle printing ink; (4) preparing a screen printing plate; (5) printing an SERS active substrate; and (6) preparing the highly repetitive SERS active substrate and tailoring the dried SERS active substrate to different sizes according to design specifications and sealing for later use. The preparation method has the following beneficial effects: the preparation process is simple and practicable without expensive instruments and equipment; and the prepared SERS active substrate is good in synergy effect, high in stability, excellent in uniformity and low in price, is convenient to save and carry, can avoid cross contamination in the detection process and can be beneficial to rapid analysis of mass samples in laboratories and the outdoor site SERS detection.
Description
Technical field
The present invention relates to SERS technology or chemical analysis technology field; Specifically; Be the preparation method at the bottom of a kind of SERS active group, especially utilize the simple and easy method at the bottom of screen printing technique prepares high duplication SERS active group in enormous quantities.
Technical background
SERS (SERS) technology can provide the information of the molecular level that other analysis and detection technology is difficult to obtain; But have detection time short, water and disturb little direct in-situ analysis, highly sensitive, advantage such as detection range is wide; And do not need conditions such as complicated pre-treatment or highly purified carrier gas, all have wide practical use in many fields such as bioanalysis, criminal investigation discriminating, food and environmental pollution detections.
Research shows; Nano particle with first subgroup metals such as Ag, Au and part transition metal prepares SERS (SERS) active group bottom material; Make between metallic effectively reinforcement metal surface plasma body resonant vibration of appropriate gathering; Thereby the electric charge that strengthens substrate surface regional area field coupled or absorbing molecules shifts, and then strengthens the raman response signal of tester.Therefore, as far as SERS check and analysis technology, be a very important research contents at the bottom of the good SERS active group of processability, also be the key factor that this technology can be applied and develop.
At present, through technology such as electrochemical activation, chemical synthesis, molecule assembling, vacuum evaporation, nanometer offset printing, beamwriter lithography methods, scholars after deliberation with prepare polytype SERS active group bottom material.But repeatability is relatively poor at the bottom of the SERS active group of short-cut methods such as electrochemical activation, chemical synthesis and molecule assembling preparation, influences the uniformity and the validity of testing result; And need advanced expensive instrument and equipment and preparation process time and effort consuming usually at the bottom of the SERS active group of technology preparations such as vacuum evaporation, nanometer offset printing, beamwriter lithography method.The problem that technology of preparing exists at the bottom of these SERS active groups has hindered the quick conversion of SERS check and analysis technology from the scientific research to the practical application.
Summary of the invention
Problem to be solved by this invention is; Overcoming on the not enough basis of prior art; Preparation method at the bottom of a kind of high duplication SERS active group is provided: be a kind of silver (Ag), gold precious metal colloid nano particles such as (Au) to be processed into screen printing ink, utilize the method at the bottom of screen printing technique prepares high duplication SERS (SERS) active group in enormous quantities again.
Advantage such as that screen printing technique has is easy and simple to handle, applied widely, controllable process property is good, wire mark product uniformity and easy miniaturization and large-scale production expense are comparatively cheap.Screen printing technique has been widely used in the fields such as preparation of throwing type electrochemistry in the Electroanalytical Chemistry or biology sensor at present.Utilize the printing-ink that screen printing technique will contain noble metal nano particles such as Ag or Au to be prepared at the bottom of the throwing type SERS active group; Can control the coherent condition and the uniformity coefficient of metallic through the method for regulating the silk screen pore size; Thereby prepare that the Raman signal reinforced effects is good, stability is high and have good uniformity, be easy to preserve carry, relatively inexpensive SERS base material; Can satisfy the rapid analysis needs of laboratory batch samples; The disposable use that SERS detects is carried out at scene beyond also making things convenient in the laboratory, avoids cross pollution.
For realizing above-mentioned purpose, the technical scheme that the present invention adopts is:
Preparation method at the bottom of a kind of high duplication SERS active group is characterized in that its step comprises:
(1) preparation noble metal nano particles colloid
Get silver nitrate (AgNO
3) be dissolved in pure water; The preparation mass ratio is 0.01～0.02% liquor argenti nitratis ophthalmicus, is heated to 85～95 ℃, dropwise adds mass ratio and be 1～2% sodium citrate aqueous solution; Continue to boil and stir after 30～50 minutes and be cooled to room temperature, obtain the Ag nano particle colloid of grey;
(2) obtain the high concentration metal nanoparticle
The Ag nano particle colloid that 10 mL steps (1) obtain was put into the centrifuge tube high speed centrifugation 8～10 minutes, remove 98%～99% supernatant liquor, take off floor height concentration metal nanoparticle with subsequent use;
(3) synthetic metal nanoparticle printing-ink
The preparation mass ratio is 8～10% sodium carboxymethyl cellulose solution; It is mixed with high concentration metal nanoparticle that step (2) obtains; The volume that said sodium carboxymethyl cellulose solution mixes with said high concentration metal nanoparticle synthesizes the high concentration metal nanoparticle printing-ink with appropriate viscosity for than 1:2～4;
(4) make screen printing screens
The screen printing screens that making is made up of hollow out round dot pattern of the same size, the diameter of said round dot is 3～10mm, and the mode that is listed as with 10 row * 10 evenly distributes, and the grid aperture of the half tone of made is 1～100 μ m;
(5) print at the bottom of SERS (SERS) active group
The screen printing screens that step (4) is made is overlying on the loading material; Add the synthetic high concentration metal nanoparticle printing-ink of step (3) at said half tone one end, adopt manually or automatic screen printing equipment is printed at the bottom of the SERS active group with appropriate viscosity;
(6) at the bottom of the preparation high duplication SERS active group
At the bottom of the SERS active group that step (5) is printed in 30～40 ℃ air dry oven dry 10～30 minutes, obtain at the bottom of the high duplication SERS active group; Can be with being cut into different size and sealing preservation according to design specification at the bottom of the dried SERS active group with subsequent use.
Further, prepare Au nano particle colloid or electrum nano particle colloid with the described method of step (1).
Further, the described loading material of step (5) is glass mat, silicon chip, sheet glass, filter paper, printing paper or potsherd.
Application process at the bottom of the high duplication SERS active group of the present invention preparation is: on being added drop-wise to the testing sample point of 5～20 μ L at the bottom of the SERS active group, adopt raman spectroscopy instrument to detect, obtain the SERS spectrogram of testing sample.
Good effect of the present invention is:
(1) preparation process is simple, need not expensive advanced instrument equipment;
(2) synergy is good at the bottom of the prepared SERS active group, stability is high, have good uniformity and cheap; Can disposable use and preservation and easy to carry; Can avoid the cross pollution in the testing process, help the rapid analysis of laboratory batch samples and carry out SERS at outdoor scene and detect;
(3) SERS check and analysis The Application of Technology and development there is certain positive effect.
Description of drawings
Accompanying drawing 1 is the preparation method's at the bottom of the high duplication SERS active group of the present invention FB(flow block);
Accompanying drawing 2 is an Ag nano particle colloid uv absorption spectra;
Accompanying drawing 3 is the photo of Ag nano particle screen printing ink;
Accompanying drawing 4 is the photo at the bottom of the high duplication SERS active group;
Accompanying drawing 5 is the sem photograph at the bottom of the high duplication SERS active group;
Accompanying drawing 6 is to the SERS spectrogram of rhodamine 6G at the bottom of the high duplication SERS active group;
Accompanying drawing 7 is that the repeatability of detection signal at the bottom of the high duplication SERS active group is investigated collection of illustrative plates as a result.
The specific embodiment
Provide the preparation method's at the bottom of the high duplication SERS active group of the present invention specific embodiment below in conjunction with accompanying drawing,, still, be noted that preparation method of the present invention is not limited to following introduction so that method of the present invention is carried out detailed explanation.
Embodiment 1
Referring to accompanying drawing 1.Preparation method at the bottom of a kind of high duplication SERS active group, its step comprises:
(1) preparation Ag nano particle colloid
Get silver nitrate (AgNO
3) being dissolved in pure water, preparation 100mL mass ratio is 0.02% AgNO
3Solution is heated to 95 ℃, dropwise adds mass ratio and be 1% sodium citrate aqueous solution 2mL, continues to boil and stir after 50 minutes to be cooled to room temperature, obtains the Ag nano particle colloid (referring to accompanying drawing 2) of stable grey.
(2) obtain high concentration Ag nano particle
The Ag nano particle colloid that the step (1) of 10 mL obtains was put into the centrifuge tube high speed centrifugation 10 minutes, remove 99% supernatant liquor, take off floor height concentration Ag nano particle with subsequent use.
(3) synthetic Ag nano particle printing-ink
The preparation mass ratio is 10% sodium carboxymethyl cellulose solution, and it is mixed with volume ratio 1:4 with high concentration Ag nano particle that step (2) obtains, synthesizes the high concentration Ag nano particle printing-ink (referring to accompanying drawing 3) with appropriate viscosity.
(4) make screen printing screens
Design is the arrangement mode even pierced pattern that distribute constituted of the round dot of 3mm with 10 row * 10 row by diameter, and with this design producing screen printing screens, the grid aperture of the screen printing screens of made is 10 μ m.
(5) print at the bottom of SERS (SERS) active group
The screen printing screens that step (4) is made is overlying on the glass mat, adds the synthetic Ag nano particle printing-ink of step (3) at an end of this half tone, adopts automatic screen printing machine to print at the bottom of the SERS active group;
Described glass mat can use silicon chip or sheet glass or filter paper or printing paper or potsherd to substitute.
(6) at the bottom of the preparation high duplication SERS active group
At the bottom of the SERS active group that step (5) is printed in 40 ℃ air dry oven dry 10 minutes, obtain at the bottom of the high duplication SERS active group;
The specification sealing that is cut into 5 row * 5 row at the bottom of the dried SERS active group is preserved, with subsequent use (referring to attaching Figure 4 and 5).
Embodiment 2
(1) preparation Ag nano particle colloid
Get silver nitrate (AgNO
3) being dissolved in pure water, preparation 100mL mass ratio is 0.01% AgNO
3Solution is heated to 85 ℃, dropwise adds mass ratio and be 2% sodium citrate aqueous solution 2mL, continues to boil and stir after 30 minutes to be cooled to room temperature, obtains the Ag nano particle colloid of stable grey.
(2) obtain high concentration Ag nano particle
The Ag nano particle colloid that the step (1) of 10 mL obtains was put into the centrifuge tube high speed centrifugation 8 minutes, remove 98% supernatant liquor, take off floor height concentration Ag nano particle with subsequent use.
(3) synthetic Ag nano particle printing-ink
The preparation mass ratio is 8% sodium carboxymethyl cellulose solution, and it is mixed with volume ratio 1:2 with high concentration Ag nano particle that step (2) obtains, synthesizes the high concentration Ag nano particle printing-ink with appropriate viscosity.
(4) make screen printing screens
Design is the arrangement mode even pierced pattern that distribute constituted of the round dot of 10mm with 10 row * 10 row by diameter, and with this design producing screen printing screens, the grid aperture of the screen printing screens of made is 100 μ m.
(5) print at the bottom of SERS (SERS) active group
The screen printing screens that step (4) is made is overlying on the glass mat, adds the synthetic Ag nano particle printing-ink of step (3) at an end of this half tone, adopts automatic screen printing machine to print at the bottom of the SERS active group;
(6) at the bottom of the preparation high duplication SERS active group
At the bottom of the SERS active group that step (5) is printed in 30 ℃ air dry oven dry 30 minutes, obtain at the bottom of the high duplication SERS active group;
The specification sealing that is cut into 5 row * 5 row at the bottom of the dried SERS active group is preserved, with subsequent use.
Embodiment 3
Preparation method at the bottom of a kind of high duplication SERS active group, its basic step be with embodiment 1, but different with embodiment 1 be: prepare Au nano particle colloid with the described method of step (1).
Embodiment 4
Preparation method at the bottom of a kind of high duplication SERS active group, its basic step be with embodiment 1, but different with embodiment 1 be:
Prepare electrum nano particle colloid with the described method of step (1);
The grid aperture of the screen printing screens of step (4) made is 1.0 μ m.
One of concrete application process at the bottom of the high duplication SERS active group of the present invention preparation is: on being added drop-wise to the rhodamine 6G solution point of 10 μ L at the bottom of the high duplication SERS active group; Adopt the Portable Raman optical spectrum appearance to detect, obtain that rhodamine is highly sensitive, the rhodamine 6G SERS spectrogram of high duplication (referring to accompanying drawing 6 and 7).
The above is merely preferred implementation method of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; Can also make the variation or the accommodation of some equivalences, variation that these are equivalent or accommodation also should be regarded as protection category of the present invention.
Claims (4)
1. the preparation method at the bottom of the high duplication SERS active group is characterized in that its step comprises:
(1) preparation noble metal nano particles colloid
Get silver nitrate (AgNO
3) be dissolved in pure water; The preparation mass ratio is 0.01～0.02% liquor argenti nitratis ophthalmicus, is heated to 85～95 ℃, dropwise adds mass ratio and be 1～2% sodium citrate aqueous solution; Continue to boil and stir after 30～50 minutes and be cooled to room temperature, obtain the Ag nano particle colloid of grey;
(2) obtain the high concentration metal nanoparticle
The Ag nano particle colloid that 10 mL steps (1) obtain was put into the centrifuge tube high speed centrifugation 8～10 minutes, remove 98%～99% supernatant liquor, take off floor height concentration metal nanoparticle with subsequent use;
(3) synthetic metal nanoparticle printing-ink
The preparation mass ratio is 8～10% sodium carboxymethyl cellulose solution; It is mixed with high concentration metal nanoparticle that step (2) obtains; The volume that said sodium carboxymethyl cellulose solution mixes with said high concentration metal nanoparticle synthesizes the high concentration metal nanoparticle printing-ink with appropriate viscosity for than 1:2～4;
(4) make screen printing screens
The screen printing screens that making is made up of hollow out round dot pattern of the same size, the diameter of said round dot is 3～10mm, and the mode that is listed as with 10 row * 10 evenly distributes, and the grid aperture of the half tone of made is 1～100 μ m;
(5) print at the bottom of the SERS active group
The screen printing screens that step (4) is made is overlying on the loading material; Add the synthetic high concentration metal nanoparticle printing-ink of step (3) at said half tone one end, adopt manually or automatic screen printing equipment is printed at the bottom of the SERS active group with appropriate viscosity;
(6) at the bottom of the preparation high duplication SERS active group
At the bottom of the SERS active group that step (5) is printed in 30～40 ℃ air dry oven dry 10～30 minutes, obtain at the bottom of the high duplication SERS active group; Can be with being cut into different size and sealing preservation according to design specification at the bottom of the dried SERS active group with subsequent use.
2. the preparation method at the bottom of the high duplication SERS active group according to claim 1 is characterized in that, prepares Au nano particle colloid with the described method of step (1).
3. the preparation method at the bottom of the high duplication SERS active group according to claim 1 is characterized in that, prepares electrum nano particle colloid with the described method of step (1).
4. the preparation method at the bottom of the high duplication SERS active group according to claim 1 is characterized in that, the described loading material of step (5) is glass mat, silicon chip, sheet glass, filter paper, printing paper or potsherd.
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| CN103115912A (en) * | 2013-01-23 | 2013-05-22 | 中国科学院合肥物质科学研究院 | Surface enhanced raman spectrum printing test paper for field test and preparation method thereof |
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Families Citing this family (1)
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009031023A (en) * | 2007-07-25 | 2009-02-12 | Keio Gijuku | Production method of substrate for surface enhanced raman spectroscopic analysis, manufacturing method of micro-tas, and the micro-tas |
| CN101676711A (en) * | 2008-09-21 | 2010-03-24 | 西北师范大学 | Substrate with surface-enhanced Raman scattering activity and preparation method thereof |
| CN102183502A (en) * | 2011-01-14 | 2011-09-14 | 楚雄师范学院 | Method for preparing nano silver film with enhanced Raman scattering substrate based on microwave technique |
-
2011
- 2011-11-11 CN CN201110355896.1A patent/CN102408094B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009031023A (en) * | 2007-07-25 | 2009-02-12 | Keio Gijuku | Production method of substrate for surface enhanced raman spectroscopic analysis, manufacturing method of micro-tas, and the micro-tas |
| CN101676711A (en) * | 2008-09-21 | 2010-03-24 | 西北师范大学 | Substrate with surface-enhanced Raman scattering activity and preparation method thereof |
| CN102183502A (en) * | 2011-01-14 | 2011-09-14 | 楚雄师范学院 | Method for preparing nano silver film with enhanced Raman scattering substrate based on microwave technique |
Non-Patent Citations (4)
| Title |
|---|
| 张孝芳 等: "表面增强拉曼光谱活性基底与纳米结构", 《检验检疫科学》 * |
| 徐蔚青: "纳米材料的SERS活性及其在光纤光谱传感器中的应用", 《中国优秀博士学位论文电子期刊库》 * |
| 王永强 等: "银/硅纳米孔柱阵列活性基底的SERS效应研究", 《光散射学报》 * |
| 高书燕 等: "表面增强拉曼散射活性基底", 《化学通报》 * |
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