CN102397597A - Nitric oxide donor gas-blood exchange device - Google Patents
Nitric oxide donor gas-blood exchange device Download PDFInfo
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- CN102397597A CN102397597A CN2010102817184A CN201010281718A CN102397597A CN 102397597 A CN102397597 A CN 102397597A CN 2010102817184 A CN2010102817184 A CN 2010102817184A CN 201010281718 A CN201010281718 A CN 201010281718A CN 102397597 A CN102397597 A CN 102397597A
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Abstract
The invention discloses a nitric oxide donor gas-blood exchange device. The device comprises a blood input device, a treating gas input device, a semipermeable membrane device and a blood transfusion device, wherein the semipermeable membrane device is separated into a gas channel and a blood channel by a gas-permeable semipermeable membrane piece; treating gas which is input by the treating gas input device through the inlet of the gas channel permeates blood which is input by the blood input device through the inlet of the blood channel by the semipermeable membrane piece; and a nitric oxide donor is produced in the blood, so that nitric oxide is provided for a human body and the physiological function of the nitric oxide is realized. The device has a simple structure and an obvious physiological effect, is convenient to operate and can effectively improve the quality of transfused blood.
Description
Technical field
The present invention relates to a kind of device, relate in particular to a kind of transfusion set that treatment gas is provided to human body to the human body blood transfusion.
Background technology
From 1818 the 1st time report about the success blood transfusion, blood transfusion becomes efficacious therapy means saving critical patient already.In recent years research shows, for severely injured, did operation, even anemia patient, it is not necessarily useful to transfuse blood.Except the reason of immunity, the blood transfusion poor effect also possibly be to cause because of prolongation, blood morphology and the biochemical untoward reaction that change produced along with the storage life.Discover, blood between the storage life owing to receive storages, maintain condition restriction, multiple composition; Especially the physiological function of erythrocyte (RBC) is impaired, and cell membrane fluidity and permeability change, and the RBC morphotropism reduces; Aggregation increases, and the cell viscoelasticity descends and causes the cell hardening.The RBC deformability is to keep one of effective dabbling principal element of microcirculation; Its quality not only can influence the oxygen supply of organ; And can influence the destructiveness of RBC when the blood capillary, the effect of influence blood transfusion, and these variations of RBC are relevant with nitric oxide production disappearance probably in preserving.
(nitric oxide is a kind of extremely unsettled biological free radical NO) to nitric oxide, and its molecule is little; Simple in structure, room temperature for gas, is slightly soluble in water down; Have fat-solublely, can be fast see through the biomembrane diffusion, extensively be found in recent years in the biological intravital various tissues.NO is a kind of new bio messenger molecule, at aspects such as the heart, cerebrovascular adjusting, nerve, immunomodulating crucial biological action is arranged, and receives people's generally attention.Yet ectogenic NO is the active small-molecule substance of a kind of chemical property, and biological half-life in vivo is very short, 3-5s only, and be easy to form toxic nitrogen oxide with oxygen or superoxide ion, stimulate the human lung, cause respiratory system disease.In addition, NO can also combine to generate methemoglobinemia with hemoglobin, reduces the oxygen carrying capacity of hemoglobin, causes anoxia asphyxia easily, thereby has limited the effectiveness and the persistence of its biological action.
(S-nitrosothiols RSNO) is the product of the sulfydryl nitrosylation of albumen, polypeptide or mercaptan compound to nitrosothiols, distributes extensively in vivo.RSNO is combined to form by the sulfydryl of NO and the thio-alcohol material mode with covalent bond, compares with free NO, and the NO under the bonding state is not easy to caught by the NO agent for capturing in the blood, and character is relatively stable than NO, and the half-life is longer than NO.RSNO can decompose generation NO in vivo, has the similar biological action with NO, has vasodilator, bronchial smooth muscle, prevents physiological functions such as platelet stickness gathering.Only pipe is like this, but the less stable of RSNO, defectives such as inorganizable specificity have all limited the performance of its physiological function.
Some precursor substances of RSNO can generate RSNO with sulfhydryl compound generation nitroso-group reactions such as micromolecular cysteine, glutathion.RSNO is the memory bank of NO in the human body, under the situation that body needs, can discharge NO and brings into play physiologic function.In blood transfusion blood, quantitatively replenish the precursor substance of RSNO, can in blood, form RSNO, thereby discharge NO, not only can improve the quality of blood transfusion blood, but also can make the RSNO of formation and the certain physiology's effect of NO performance of release.
Summary of the invention
Primary and foremost purpose of the present invention is to the problem that above-mentioned prior art exists a kind of nitric oxide donors QI and blood switch to be provided; To treat through the penetrable type semipermeable membrane of gas and to import human body after gas is penetrated into blood; Not only can improve the quality of blood transfusion blood effectively, but also can make it in human body, bring into play certain physiology's effect.
In order to achieve the above object; One aspect of the present invention provides a kind of semipermeable membrane device of nitric oxide donors QI and blood switch; Comprise airtight container, be arranged on treatment gas penetrable type semipermeable membrane spare in the said container and gas passage and the blood channel that is separated into by the penetrable type of said treatment gas semipermeable membrane spare, wherein; Treatment gas in the gas passage penetrates into via semipermeable membrane spare in the blood of blood channel, in blood, produces nitric oxide donors.
Nitric oxide donors of the present invention is a nitrosothiols, and described treatment gas comprises the precursor substance of nitrosothiols, and like nitrous ether (ethyl nitrite) gas, nitrous ether (ethyl nitrite) can react the generation nitrosothiols in blood.The gaseous precursors material of other nitrosothiols also is applicable to the present invention.
In the present invention, treatment gas comprises nitrous ether (ethyl nitrite) gas and diluent gas, and wherein, diluent gas is one or more in nitrogen, the oxygen.The volumetric concentration scope of nitrous ether (ethyl nitrite) is 1-100000ppm in the treatment gas.
The semipermeable membrane spare of semipermeable membrane device comprise support with overlay on the penetrable type semipermeable membrane of gas on the said support, or dividing plate with holes be installed in the penetrable type semipermeable membrane of gas in the hole, said support, said dividing plate with holes are fixed in the semipermeable membrane device.
Semipermeable membrane spare can also be the transparent hollowfibre semi-permeable membrance of gas.Semipermeable membrane spare can be the transparent hollowfibre semi-permeable membrance of one or more gas.When semipermeable membrane spare was the many transparent hollowfibre semi-permeable membrances of gas, the transparent hollowfibre semi-permeable membrance of gas was parallel, be spaced, and can be arranged in square, circle or other shape.The two ends of the transparent hollowfibre semi-permeable membrance of each root gas are connected with part flow arrangement respectively, and part flow arrangement is fixed on the semipermeable membrane device.Wherein, part flow arrangement can be the pipeline that is interconnected.
In semipermeable membrane device, gas flow in the opposite direction in the flow direction of blood and the gas passage in the blood channel.
Semipermeable membrane of the present invention adopts the macromolecule permeable membrane to process; Semipermeable membrane does not allow water and other polymer substances to pass through; Only allow the treatment gas molecule to pass through, blood carries out gas exchange with treatment gas through semipermeable membrane, and blood does not directly contact mutually with treating between the gas.Semipermeable membrane can be flat diaphragm type or doughnut formula.
Flat diaphragm type is used to overlay on the said support or is installed in the hole of said dividing plate with holes.The doughnut formula is used for the transparent hollowfibre semi-permeable membrance of gas.
The present invention provides a kind of nitric oxide donors QI and blood switch on the other hand; Comprise blood input equipment, treatment gas input device, semipermeable membrane device and transfusion set; Wherein, Be separated into gas passage and blood channel by the penetrable type of gas semipermeable membrane spare in the semipermeable membrane device, gas input device is penetrated in the blood of blood input equipment via the input of blood channel inlet via semipermeable membrane spare via the treatment gas of gas passage inlet input, in blood, produce nitric oxide donors; The input of transfusion set connects the blood channel outlet.
Nitric oxide donors of the present invention is a nitrosothiols, and described treatment gas comprises the precursor substance of nitrosothiols, and like nitrous ether (ethyl nitrite) gas, nitrous ether (ethyl nitrite) can react the generation nitrosothiols in blood.The gaseous precursors material of other nitrosothiols also is applicable to the present invention.
Treatment gas comprises nitrous ether (ethyl nitrite) gas and diluent gas, and wherein, diluent gas is one or more in nitrogen, the oxygen.The volumetric concentration scope of nitrous ether (ethyl nitrite) is 1-100000ppm in the treatment gas.
In semipermeable membrane device, gas flow in the opposite direction in the flow direction of blood and the gas passage in the blood channel.
Semipermeable membrane spare in the semipermeable membrane device is fixed in the semipermeable membrane device.Semipermeable membrane spare comprises support and overlays on the penetrable type semipermeable membrane of gas on the said support that said support is fixed in the semipermeable membrane device.
Semipermeable membrane spare also can comprise dividing plate with holes and be installed in the penetrable type semipermeable membrane of gas in the hole that said dividing plate is fixed in the semipermeable membrane device.
Semipermeable membrane spare can also be the transparent hollowfibre semi-permeable membrance of gas.The hollow space of the transparent hollowfibre semi-permeable membrance of gas is a blood channel, and the outer wall of the transparent hollowfibre semi-permeable membrance of gas and the space between the semipermeable membrane device are gas passage; The hollow space of the transparent hollowfibre semi-permeable membrance of gas also can be gas passage, and at this moment, the outer wall of the transparent hollowfibre semi-permeable membrance of gas and the space between the semipermeable membrane device are blood channel.
Semipermeable membrane spare can be the transparent hollowfibre semi-permeable membrance of one or more gas.When semipermeable membrane spare was the many transparent hollowfibre semi-permeable membrances of gas, the transparent hollowfibre semi-permeable membrance of gas was parallel, be spaced, and can be arranged in square, circle or other shape.The two ends of the transparent hollowfibre semi-permeable membrance of each root gas are connected with part flow arrangement respectively, and part flow arrangement is fixed on the semipermeable membrane device.Wherein, part flow arrangement can be the pipeline that is interconnected.
The hollow space of each the root semipermeable membrane in many transparent hollowfibre semi-permeable membrances of gas is blood channel, and the outer wall of each root semipermeable membrane and the space between the semipermeable membrane device are gas passage in many transparent hollowfibre semi-permeable membrances of gas; The hollow space of each the root semipermeable membrane in many transparent hollowfibre semi-permeable membrances of gas also can be gas passage; At this moment, the outer wall of each root semipermeable membrane and the space between the semipermeable membrane device are blood channel in many transparent hollowfibre semi-permeable membrances of gas.
On semipermeable membrane device, be provided with blood channel inlet, blood channel outlet, gas passage inlet and gas passage outlet.The blood of storing in the blood pot in the blood input equipment gets into blood channel through the blood feeder connection, flow to transfusion bottle from the blood channel outlet then; The treatment gas of storing in the gas tank in the gas input device gets into gas passage through the gas passage inlet, discharges through outlet pipe from the gas passage outlet then.The treatment gas of discharging through outlet pipe can reclaim, or flows directly in the gas tank and recycle.
Semipermeable membrane adopts the macromolecule permeable membrane to process; Semipermeable membrane does not allow water and other polymer substances to pass through; Only allow the treatment gas molecule to pass through, blood carries out gas exchange with treatment gas through semipermeable membrane, and blood does not directly contact mutually with treating between the gas.The penetrable type semipermeable membrane of gas can be flat diaphragm type or doughnut formula.
Flat diaphragm type is used to overlay on the said support or is installed in the hole of said dividing plate with holes.The doughnut formula is used for the transparent hollowfibre semi-permeable membrance of gas.
Blood input equipment comprises the blood pot of preserving blood, connects the blood conduit of said blood pot and said blood channel inlet and is arranged on the valve on the blood conduit, and the blood pot of preserving blood also can be a bags of blood.
The treatment gas input device comprises the gas tank of preserving treatment gas, connects the gas pipeline of said gas tank and said gas passage inlet and is arranged on the valve on the gas pipeline.
Transfusion set comprises transfusion bottle and blood transfusion tube, and the input of transfusion bottle connects the blood channel outlet through pipeline, and the outfan of transfusion bottle is connected with blood transfusion tube.Transfusion bottle in the transfusion set also can be a transfusion bags.
Description of drawings
Fig. 1 is first kind of structural representation of semipermeable membrane blood processor of the present invention;
Fig. 2 is second kind of structural representation of semipermeable membrane blood processor of the present invention;
Fig. 3 is the third structural representation of semipermeable membrane blood processor of the present invention.
The specific embodiment mode
Further describe the present invention below in conjunction with specific embodiment, these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment with form or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall in protection scope of the present invention the details of technical scheme of the present invention.
Shown in Fig. 1-3, nitric oxide donors QI and blood switch of the present invention comprises blood input equipment 1, treatment gas input device 2, semipermeable membrane device 3 and transfusion set 4.
Treatment gas input device 2 comprises the gas tank 21 of preserving treatment gas, connects the gas pipeline of gas tank 21 and gas passage inlet 33 and is arranged on the valve 22 on the gas pipeline.Be stored in treatment gas in the gas tank 21 after valve 22 is regulated flows, in gas pipeline, flow in the semipermeable membrane devices 3 through gas passage inlet 33.
Be separated into gas passage 31 and blood channel 32 by the penetrable type of gas semipermeable membrane spare 5 in the semipermeable membrane device 3; Gas input device 2 is penetrated in the blood of blood input equipment 1 via 34 inputs of blood channel inlet via semipermeable membrane spare 5 via the treatment gas of gas passage inlet 33 inputs, in blood, produce nitric oxide donors.
As shown in Figure 1; Semipermeable membrane spare 5 in the semipermeable membrane device 3 comprises support and overlays on the penetrable type semipermeable membrane of gas on the said support; Support is fixed in the semipermeable membrane device 3, the gas passage 31 of the sealing that semipermeable membrane device 3 is separated into and the blood channel 32 of sealing.Semipermeable membrane spare 5 in the semipermeable membrane device 3 also can comprise dividing plate with holes and be installed in the penetrable type semipermeable membrane of gas in the hole that said dividing plate is fixed in the semipermeable membrane device.
Be stored in blood in the blood pot 11 after valve 12 is regulated flows; The blood channel 32 that in blood conduit, flows in the semipermeable membrane device 3 through blood feeder connection 34; Simultaneously, be stored in treatment gas in the gas tank 21 after valve 22 is regulated flows, the gas passage 31 that in gas pipeline, flows in the semipermeable membrane devices 3 through gas passage inlet 33; Wherein, in the blood channel 32 in the circulating direction of blood and the gas passage 31 treatment gas circulating direction opposite.In semipermeable membrane device 3, the be placed in both sides of semipermeable membrane spare 5 of treatment gas and blood, directly contact mutually each other, treatment gas penetrates in the blood through the penetrable type semipermeable membrane of the gas on the semipermeable membrane spare 5.Ooze the blood that treatment gas is arranged and flow in the transfusion bottle 6, then through blood transfusion tube 7 input human bodies through blood channel outlet 35.The gas that does not penetrate in the gas passage 31 in the blood exports 36 through gas passage, discharges through outlet pipe 8.The treatment gas of discharging through outlet pipe 8 can reclaim, or flows directly in the gas tank 21 and recycle.
As shown in Figure 2, semipermeable membrane spare 5 is the transparent hollowfibre semi-permeable membrance 9 of gas, and the transparent hollowfibre semi-permeable membrance 9 of gas is fixed in the semipermeable membrane device 3, the gas passage 31 of the sealing that semipermeable membrane device 3 is separated into and the blood channel 32 of sealing; Wherein, the hollow space of the transparent hollowfibre semi-permeable membrance 9 of gas constitutes described blood channel 32, and the outer wall of the transparent hollowfibre semi-permeable membrance 9 of gas and the space between the semipermeable membrane device 3 are gas passage 31.Treatment gas in the gas passage 31 penetrates in the blood of blood channel 32 via the transparent hollowfibre semi-permeable membrance 9 of gas, oozes the blood that treatment gas is arranged and flows in the transfusion bottle 6 through blood channel outlet 35, then through blood transfusion tube 7 input human bodies.The gas that does not penetrate in the gas passage 31 in the blood exports 36 through gas passage, discharges through outlet pipe 8.
The hollow space of the transparent hollowfibre semi-permeable membrance of gas also can be gas passage, and at this moment, the outer wall of the transparent hollowfibre semi-permeable membrance of gas and the space between the semipermeable membrane device are blood channel.
As shown in Figure 3, semipermeable membrane spare 5 is the three transparent hollowfibre semi-permeable membrance 9a of gas, 9b and 9c, also can be other many.The transparent hollowfibre semi-permeable membrance 9a of gas, 9b, 9c be parallel, be spaced quadrate, also can be arranged in circle or other shape.The end of the transparent hollowfibre semi-permeable membrance 9a of gas, 9b, 9c is connected with part flow arrangement 10a respectively, and part flow arrangement 10a is fixed in the semipermeable membrane device 3, and is connected with blood channel inlet 34; The other end of the transparent hollowfibre semi-permeable membrance 9a of gas, 9b, 9c is connected with part flow arrangement 10b respectively, and part flow arrangement 10b is fixed in the semipermeable membrane device 3, and is connected with blood channel outlet 35.The transparent hollowfibre semi-permeable membrance 9a of gas, 9b, the hollow space 32a of 9c, 32b, 32c are blood channel, and the outer wall of the transparent hollowfibre semi-permeable membrance 9a of gas, 9b and 9c and the space between the semipermeable membrane device 3 are gas passage 31.
Effusive blood flows among the part flow arrangement 10a through blood feeder connection 34 from blood pot 11; Flow into respectively among blood channel 32a, 32b, the 32c through part flow arrangement 10a; Simultaneously; Effusive stream of therapeutic gas is gone into gas passage 31 from gas tank 21, and treatment gas penetrates into respectively in the blood of blood channel 32a, 32b and 32c through the transparent hollowfibre semi-permeable membrance 9a of gas, 9b and 9c, oozes the blood that treatment gas is arranged and flows among the part flow arrangement 10b through blood passage 32a, 32b and 32c; Flow in the transfusion bottle 6 through blood channel outlet 35 then, then through blood transfusion tube 7 input human bodies.The gas that does not penetrate in the gas passage 31 in the blood exports 36 through gas passage, discharges through outlet pipe 8.
The hollow space of the transparent hollowfibre semi-permeable membrance 9a of gas, 9b and 9c also can be gas passage, and at this moment, the outer wall of the transparent hollowfibre semi-permeable membrance 9a of gas, 9b and 9c and the space between the semipermeable membrane device 3 are blood channel.
Treatment gas of the present invention is the precursor substance of nitrosothiols, is the nitrous ether (ethyl nitrite) gas with nitrogen dilution, and the volumetric concentration scope of nitrous ether (ethyl nitrite) is 1000ppm in the treatment gas.
Semipermeable membrane among the present invention adopts the macromolecule permeable membrane to process; Blood carries out gas exchange with treatment gas through semipermeable membrane; Semipermeable membrane does not allow water and other polymer substances to pass through, and only allows a treatment gas molecule to pass through, and blood does not directly contact mutually with treating between the gas.
In the present invention; Can regulate the flow of blood and treatment gas through valve 12 and valve 22 respectively; Through parameters such as the material of the penetrable type semipermeable membrane of gas, aperture are selected; Through the concentration of nitrous ether (ethyl nitrite) in the treatment gas is regulated, make the treatment gasometry penetrate into the purpose of blood thereby reach.
With the precursor substance of nitrosothiols as treatment gas; Carry out the QI and blood exchange through nitric oxide donors QI and blood switch of the present invention; Treatment gas is penetrated in the blood, generate nitrosothiols with sulfhydryl compound generation nitroso-group reactions such as cysteine in the blood, glutathion, thereby discharge nitric oxide; Make the erythrocyte in the blood keep deformability preferably; Make it in the blood transfusion process, not be vulnerable to the destruction of blood capillary, thereby improved the quality of blood transfusion blood, guaranteed the effect of blood transfusion.
When human body acute hemorrhage occurs and during the hypohemoglobinemia that caused by reasons such as sickleshaped cellulous anemias; A large amount of free hemoglobin have consumed a large amount of NO in the blood, cause vasoconstriction, cause the hemoglobin oxygen carrying capacity to descend causing situation such as the no resurgent in blood transfusion back, anaerobic condition improvement be bad because of RSNO reduces in the banked blood; With the precursor substance of nitrosothiols as treatment gas; Use in the nitric oxide donors QI and blood switch of the present invention, treatment gas is penetrated in the blood, through increasing the content of RSNO in the blood; Can greatly improve blood transfusion usefulness, reduce unnecessary blood transfusion and reduce transfusion volume.
With the precursor substance of nitrosothiols as treatment gas; Through carrying out the QI and blood exchange in the nitric oxide donors QI and blood switch of the present invention; Treatment gas penetrates in the blood, can be used for the cardiovascular disease aspect, plays the effect of alleviating vascular smooth muscle spasm, blood vessel dilating; Can also be used for aspect of respiratory disease, play the effect of diastole bronchial smooth muscle, thus relieving asthma effectively; In addition; Can also be used for multiple thromboembolism, ischemic diseases such as pulmonary thromboembolism, venous thrombosis, coronary heart disease, apoplexy, peripheral angiopathy, vasculitis, hypertension, rheumatic heart disease and change lobe postoperative, disseminated inravascular coagulation, antiphospholipid antibody syndrome, heritability and be prone to before and after bolt disease, nephrotic syndrome, hemodialysis and the many surgical operations etc., prevent and treat through anticoagulation that thromboembolism forms or recurrence.
Claims (10)
1. the semipermeable membrane device of a nitric oxide donors QI and blood switch is characterized in that, comprising:
Airtight container;
Be arranged on the penetrable type of the gas semipermeable membrane spare (5) in the said container;
The gas passage (31) and the blood channel (32) that are separated into by the penetrable type of said gas semipermeable membrane spare (5);
Wherein, the treatment gas in the gas passage (31) penetrates in the blood of blood channel (32) via semipermeable membrane spare (5), in blood, produces nitric oxide donors.
2. semipermeable membrane device as claimed in claim 1 is characterized in that said semipermeable membrane spare (5) comprises support and overlays on the penetrable type semipermeable membrane of gas on the said support.
3. device as claimed in claim 1 is characterized in that said semipermeable membrane spare (5) is the transparent hollowfibre semi-permeable membrance of gas (9).
4. nitric oxide donors QI and blood switch comprises:
Blood input equipment (1);
Treatment gas input device (2);
Semipermeable membrane device (3); Be separated into gas passage (31) and blood channel (32) by the penetrable type of gas semipermeable membrane spare (5) in it; Gas input device (2) is penetrated in the blood of blood input equipment (1) via blood channel inlet (34) input via semipermeable membrane spare (5) via the treatment gas of gas passage inlet (33) input, in blood, produce nitric oxide donors; And
Transfusion set (4), its input connects blood channel outlet (35).
5. device as claimed in claim 4 is characterized in that said semipermeable membrane spare (5) comprises dividing plate with holes and is installed in the penetrable type semipermeable membrane of gas in the hole.
6. device as claimed in claim 4 is characterized in that said semipermeable membrane spare (5) is the transparent hollowfibre semi-permeable membrance of gas (9).
7. device as claimed in claim 4 is characterized in that said blood input equipment (1) comprises;
Preserve the blood pot (11) of blood;
The blood conduit that connects said blood pot (11) and said blood channel inlet (34);
Be arranged on the valve (12) on the blood conduit.
8. device as claimed in claim 4 is characterized in that said treatment gas input device (2) comprises;
Preserve the gas tank (21) of treatment gas;
The gas pipeline that connects said gas tank (21) and said gas passage inlet (33);
Be arranged on the valve (22) on the gas pipeline.
9. like claim 1 or 4 described devices, it is characterized in that said semipermeable membrane spare (5) comprises dividing plate with holes and is installed in the penetrable type semipermeable membrane of gas in the hole.
10. like claim 1 or 4 described devices; It is characterized in that said nitric oxide donors is a nitrosothiols; Said treatment gas comprises nitrous ether (ethyl nitrite) and diluent gas; Wherein diluent gas is one or more in nitrogen, the oxygen, and the volumetric concentration scope of nitrous ether (ethyl nitrite) is 1-100000ppm in the treatment gas.
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| CN2010102817184A CN102397597A (en) | 2010-09-14 | 2010-09-14 | Nitric oxide donor gas-blood exchange device |
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| CN2010102817184A CN102397597A (en) | 2010-09-14 | 2010-09-14 | Nitric oxide donor gas-blood exchange device |
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Cited By (6)
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| WO2014070620A1 (en) * | 2012-10-29 | 2014-05-08 | Baylor College Of Medicine | Apparatus for nitric oxide delivery to a patent and methods of using same |
| CN104147650A (en) * | 2014-08-27 | 2014-11-19 | 苏州承乐电子科技有限公司 | Blood transfusion and oxygen supplementation device |
| CN105307695A (en) * | 2013-02-07 | 2016-02-03 | 密执安大学评议会 | Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (snap)-doped nitric oxide release polymers with enhanced stability |
| CN106377811A (en) * | 2016-08-29 | 2017-02-08 | 安徽通灵仿生科技有限公司 | Vein film type oxygenation device and oxygenation method |
| CN111201048A (en) * | 2017-06-08 | 2020-05-26 | 凯斯西储大学 | Apparatus and method for nitrosation of blood |
| CN113797404A (en) * | 2021-01-06 | 2021-12-17 | 郝云玲 | Device for supplementing Nitric Oxide (NO) to blood |
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| CN111201048A (en) * | 2017-06-08 | 2020-05-26 | 凯斯西储大学 | Apparatus and method for nitrosation of blood |
| JP2020523094A (en) * | 2017-06-08 | 2020-08-06 | ケース ウエスタン リザーブ ユニバーシティ | Device and method for nitrosylation of blood |
| JP7350660B2 (en) | 2017-06-08 | 2023-09-26 | ケース ウエスタン リザーブ ユニバーシティ | Device and method for blood nitrosylation |
| CN113797404A (en) * | 2021-01-06 | 2021-12-17 | 郝云玲 | Device for supplementing Nitric Oxide (NO) to blood |
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