CN102389489A - Chinese medicament for comprehensively preventing and treating diabetic complications - Google Patents

Abstract

The invention provides a Chinese medicament for comprehensively preventing and treating diabetic complications, and belongs to the field of Chinese medicaments for treating diabetes mellitus. The Chinese medicament has the advantages of good effect and quick action. The Chinese medicament is prepared from rehmannia, Chinese angelica, gingko leaves, lucid ganoderma, pseudo-ginseng and other raw materials. The Chinese medicament has the effects of strengthening the body resistance to consolidate the constitution, tonifying vital energy and nourishing blood, clearing away heat and toxic materials, activating blood and dissolving stasis, and invigorating pulse. The Chinese medicament has comprehensive prevention and treatment effect to various complications of the diabetes mellitus, and has the advantages of remarkable effect and definite drug efficacy.

Description

A kind of Chinese medicine of integrated control diabetic complication

Technical field

The invention belongs to the field of Chinese medicines of treatment diabetes.

Background technology

Diabetes are multiple complication diseases.Diabetes are not only carbohydrate metabolism disturbance, also cause the disorder of albumen, fat, vitamin, water and salt metabolism thus, thereby have influence on the metabolism of whole body, and the complication that causes almost involves each system, each internal organs of whole body.The high complication rate of diabetes has caused high fatality rate and high disability rate.At present, be used to treat the Western medicine and the Chinese medicine of diabetic complication, exist the problem of two aspects: the one, effect is obvious inadequately, and the 2nd, it is slower to take effect, and lacks the medicine of the many complication of a kind of integrated control diabetes.The patient is three, under four kind of simultaneous situation of complication, has to treat the head when the head aches, foot cures foot bitterly, and everybody is very dissatisfied to this.

To problem set forth above; The present invention provides a kind of Chinese medicine of integrated control diabetic complication; It can solve in the past in this type of western medicines in treatment effect inadequately obviously, take effect slower; And treatment lacks comprehensive problem, and effective, instant effect has that drug effect is definite, quick result and an advantage comprehensive, many targeting.

Summary of the invention

The present invention realizes through following technical scheme:

1, a kind of Chinese medicine of integrated control diabetic complication adopts the raw material of Chinese medicine preparation, and the weight proportion of raw material of Chinese medicine is:

Radix Rehmanniae 6---9 parts of 18 parts of Radix Angelicae Sinensis 5---15 parts of Folium Ginkgos 3---

3 parts of Ganodermas 6---18 portions of Radix Notoginseng 1---

The Chinese medicine of this integrated control diabetic complication is processed by following method:

(1) by above-mentioned weight ratio, Radix Rehmanniae, Radix Angelicae Sinensis, Folium Ginkgo, Ganoderma are extracted with conventional water extraction process, process extractum, oven dry is pulverized, and gets the extract fine powder;

(2) by above-mentioned weight ratio, Radix Notoginseng is ground into fine powder, mixes, stir, process Chinese medicine granules, capsule, tablet with above-mentioned (1) extract fine powder.

The present invention is according to the folk tradition prescription, and the theory according to traditional Chinese medical science the body resistance strengthening and constitution consolidating, blood circulation promoting and blood stasis dispelling develops meticulously.We think that though that diabetic complication has is multiple, it is three kinds of pathological changes in essence in research: the one, and diabetic microvascular complication is such as diabetic nephropathy, retinopathy; The 2nd, diabetictrunk angiopathy is such as diabetic cardiopathy, acral necrosis; The 3rd, diabetic neuropathy, such as diabetic numbness of extremities, paraesthesia, diarrhoea, constipation, gastroparalysis, pruritus etc., and neuropathy also is to cause neural foster the causing of losing by the blood supply insufficiency that diabetes trunk and microangiopathies cause after all.So we think, the pathogenesis of diabetic complication---no matter microangiopathies, macroangiopathy, still neuropathy, " void ", " heat " and " stasis of blood " mainly due to.The general hypoimmunity of diabetics, cloudy liquid loses empty, gives birth in the deficiency-heat, causes hyperlipidemia, the resistance of the blood vessel stasis of blood, blood flow is slow, tissue and organ blood supply insufficiency.This is the common basic reason of all complication formation and developments.In view of the above, the present invention attaches most importance to the body resistance strengthening and constitution consolidating, enhancing immunity, the benefiting QI and nourishing blood heat clearing away, and blood circulation promoting and blood stasis dispelling is promoted blood circulation, and aspect complication such as integrated control diabetic nephropathy, heart disease, retinopathy, acral necrosis and obstinate diarrhoea, has obtained remarkable result.Clinical practice proves that a diabetics seldom has only a kind of complication, but often have three simultaneously, a plurality of complication such as four kind; Taking the way of " treating the head when the head aches; foot is cured foot bitterly ", prevent isolatedly, control and alleviate separately singly, is not clever act.Value of the present invention is, its not only effective, instant effect, and, have mitigations comprehensive, many targeting to comprising many complication of diabetic microvascular complication, macroangiopathy, neuropathy.Be fit to diabetics after making a definite diagnosis; Prevention and alleviation diabetic complication; Make the complication that is in early stage state in a large number be able to clear up or reverse; Make the complication that is in mid-term be able to alleviate and control, thereby improve patient's health level, reduce the high fatality rate and the disability rate of diabetic complication.Ganoderma, Radix Rehmanniae the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood among the we; The tonification the five internal organs, enhancing human body immunity power, " removing " effect of immunity makes blood clean; Rubbish such as unnecessary lipid, uric acid excretes in the blood; Blood is thickness no longer, but rich mobile, and this is to improve sanguimotor basis and prerequisite; Minister is with Radix Angelicae Sinensis, Radix Notoginseng blood-supplementing blood-nourishing, and blood circulation promoting and blood stasis dispelling is promoted blood circulation, and Radix Angelicae Sinensis and Radix Notoginseng all have the function of enhancing immunity, and " repairing " effect of immunity makes the fat speckle on the blood vessel wall be able to reduce, and blood vessel stasis of blood plug is able to alleviate, and intravascular space broadens, and blood supply is unobstructed; Modern Chinese medicine is thought, qi as the commander of blood, and Ganoderma, Radix Rehmanniae and Radix Angelicae Sinensis, Radix Notoginseng are associated with, the prosperous hemapodium of gas, the power that blood circulation promoting and blood stasis dispelling is promoted blood circulation is more outstanding, and this is that the diabetic complication patient becomes " blood supply insufficiency " key into " blood supply is full "; Radix Rehmanniae sweetness and bitterness and trembling with fear, but bitter cold heat clearing away, but sweet cold nourishing YIN, so Radix Rehmanniae has clearing away heat and cooling blood, the effect of YIN nourishing and the production of body fluid promoting; Assistant is astringed the lung with Folium Ginkgo, relievings asthma, and blood circulation promoting and blood stasis dispelling nourishes heart; To strengthen maintenance to cardiovascular and cerebrovascular vessel; Modern pharmacology proves, the contained flavonoid ability of Folium Ginkgo blood vessel dilating, blood flow increasing; Suppress the effect of platelet activating factor, this is that trunk, blood capillary and the neuropathy of preventing and treating diabetes are necessary.All medicine compatibilities bring out the best in each other, and play the body resistance strengthening and constitution consolidating altogether, benefiting QI and nourishing blood, and replenishing YIN and removing heat, the merit that blood circulation promoting and blood stasis dispelling is promoted blood circulation, effective, instant effect has the Comprehensive Treatment effect to the many complication of diabetes, and it is definite to have drug effect, the advantage of quick result.

The specific embodiment

Through following embodiment the present invention is done and to specify:

1, get following prescription (weight is unit by gram):

Radix Rehmanniae 700 gram Radix Angelicae Sinensis 600 gram Folium Ginkgos 400 grams

Ganoderma 700 gram Radix Notoginseng 100 grams

Press predetermined weight, Radix Rehmanniae, Radix Angelicae Sinensis, Folium Ginkgo, Ganoderma are extracted, process extract fine powder 240 grams with conventional water extraction process; Radix Notoginseng is ground into fine powder, mixes, stir with said extracted thing fine powder; Process fine particle; The capsule of packing into No. 0 is processed 1133 of Chinese medicinal capsules, and every capsules includes Chinese medicine fine powder and extract 0.3 gram.

2, get following prescription (weight is unit by gram):

Radix Rehmanniae 1200 gram Radix Angelicae Sinensis 1000 gram Folium Ginkgos 600 grams

Ganoderma 1200 gram Radix Notoginseng 200 grams

By above-mentioned same method, process 2000 of Chinese medicinal capsules, every capsules includes Chinese medicine fine powder and extract 0.3 gram.

3, get following prescription (weight is unit by gram):

Radix Rehmanniae 1800 gram Radix Angelicae Sinensis 1500 gram Folium Ginkgos 900 grams

Ganoderma 1800 gram Radix Notoginseng 260 grams

By above-mentioned same method, process 2866 of Chinese medicinal capsules, every capsules includes Chinese medicine fine powder and extract 0.3 gram.

4, get following prescription (by weight):

4 parts of 5 parts of Folium Ginkgos of 6 parts of Radix Angelicae Sinensis of Radix Rehmanniae

1 part of 6 portions of Radix Notoginseng of Ganoderma

By above-mentioned same method, process Chinese medicinal capsule, every capsules includes Chinese medicine fine powder and extract 0.3 gram.

5, get following prescription (by weight):

7 parts of 13 parts of Folium Ginkgos of 15 parts of Radix Angelicae Sinensis of Radix Rehmanniae

2 parts of 15 portions of Radix Notoginseng of Ganoderma

By above-mentioned same method, process Chinese medicinal capsule, every capsules includes Chinese medicine fine powder and extract 0.3 gram.

Clinical data:

The present invention respectively selects a pathological changes to represent in the complication of three types of diabetes---and diabetic renal papillary necrosis (microangiopathies), acromegaly necrosis diabetes (macroangiopathy), diabetic diarrhea (neuropathy) are example, carry out clinical observation.

1, diabetic renal papillary necrosis is observed 16 examples.The selection diabetic renal papillary necrosis is a standard: the diabetics eyes are sticky, binocular dryness, eye socket pain; Visual deterioration, blurred vision; That retina occurs is hemorrhage, edema, ooze out.As above symptom can be made a definite diagnosis.In making a definite diagnosis the object of observation, male's 9 examples, women's 7 examples do not have other serious disease, and the age is 41 years old-72 years old, 62.1 years old mean age.

Efficacy determination:

(1) produce effects: the sticky disappearance of eyes, eyes are clear and bright; Binocular dryness disappears, and eyes are comfortable; Blurred vision is alleviated, and vision improves more than 0.1; The white macula that the optical fundus occurs, macula lutea, blood stain quantity reduce, and area dwindles.

(2) effective: the dry and astringent disappearance of eyes, blurred vision is alleviated.

(3) invalid: the disease no change.

During clinical experiment, withdraw other medicines and health nutrient.Taking the Chinese medicinal capsule that embodiment of the present invention 2 is made, observed 3 months, is a course of treatment.Instructions of taking: every day 2 times, each 4 capsules, every capsules include Chinese medicine fine powder and extract 0.3 gram, warm water delivery service after meal, symptom promptly has alleviation after 1 month, take 3 months after, symptom is obviously improved.16 philtrums of clinical experiment, produce effects 5 people, effective 10 people, invalid 1 people, total effective rate 93.7%.

2, acromegaly necrosis diabetes is observed 12 examples.Selecting the tcm diagnosis diabetic foot is standard: the diabetics emaciated physique, and limb is soft weak; Suffer from limb and send out cold, poor blood circulation; The lower limb weak and faint pulse, intermittent claudication; Suffer from limb skin blackout, blue, tissue necrosis; Numb limbs and tense tendons, acrodynia; Suffer from limb acra ulcer, fester, disunion for a long time.As above symptom can be made a definite diagnosis.In making a definite diagnosis the object of observation, male's 7 examples, women's 5 examples do not have other serious disease, and the age is 52 years old-76 years old, 62.7 years old mean age.

Efficacy determination:

(1) produce effects: body constitution strengthens, on one's body energetically; Limbs are warm, send out cool the disappearance; Skin color is progressively bleached (normal skin color) by black purple, and blood circulation obviously improves; Trouble acroanesthesia, acrodynia obviously alleviate; Acra festers and obviously alleviates or healing.

(2) effective: body constitution strengthens, and on one's body energetically, limbs are warm, and blood circulation improves; Numb limbs and tense tendons, pain are alleviated to some extent.

(3) invalid: the disease no change.

During clinical experiment, withdraw other medicines and health nutrient.Taking the Chinese medicinal capsule that embodiment of the present invention 2 is made, observed 6 months, is a course of treatment.Instructions of taking: every day 2 times, each 4 capsules, every capsules include Chinese medicine fine powder and extract 0.3 gram, warm water delivery service after meal, symptom promptly has alleviation after 1 month, take 6 months after, symptom is obviously improved.12 philtrums of clinical experiment, produce effects 4 people, effective 7 people, invalid 1 people, total effective rate 91.6%.

3, diabetic diarrhea is observed 8 examples.Selecting traditional Chinese medical science diabetic diarrhea is standard: diabetics is suffered from diarrhoea throughout the year, and is continuous more than 3 months, defecate rare water sample or not molding; Use antibiotic therapy not have positive effect.As above symptom can be made a definite diagnosis.In the object of clinical observation, male's 6 examples, women's 2 examples do not have other serious disease, and the age is 42 years old-73 years old, 60.3 years old mean age.

Efficacy determination:

1, produce effects: diarrhoea stops, the stool molding; Defecate 1 ~ 2 day once, defecation is smooth and easy.

2, effective: loose stool stops, the stool basic forming.

3, invalid: the disease no change.

During clinical experiment, withdraw other medicines and nutrient and healthcare products.Take embodiment of the present invention 2 and make Chinese medicinal capsule, observing 3 months is a course of treatment.Instructions of taking: every day 2 times, each 4 capsules, every capsules include Chinese medicine fine powder and extract 0.3 gram, warm water delivery service after meal, symptom promptly has alleviation after 1 month, take 3 months after, symptom is obviously improved.8 philtrums of clinical experiment, produce effects 3 people, effective 4 people, invalid 1 people, total effective rate 87.5%.

Claims (1)

1. the Chinese medicine of an integrated control diabetic complication is characterized in that: said Chinese medicine is to adopt the raw material of Chinese medicine preparation, and the weight proportion of raw material of Chinese medicine is:

Radix Rehmanniae 6---9 parts of 18 parts of Radix Angelicae Sinensis 5---15 parts of Folium Ginkgos 3---

3 parts of Ganodermas 6---18 portions of Radix Notoginseng 1---

The Chinese medicine of this integrated control diabetic complication is processed by following method:

(1) by above-mentioned weight ratio, Radix Rehmanniae, Radix Angelicae Sinensis, Folium Ginkgo, Ganoderma are extracted with conventional water extraction process, process extractum, oven dry is pulverized, and gets the extract fine powder;

(2) by above-mentioned weight ratio, Radix Notoginseng is ground into fine powder, mixes, stir, process Chinese medicine granules, capsule, tablet with above-mentioned (1) extract fine powder.