CN102366494A - Chinese patent medicine for treating hypercortisolism - Google Patents
Chinese patent medicine for treating hypercortisolism Download PDFInfo
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- CN102366494A CN102366494A CN201110299239XA CN201110299239A CN102366494A CN 102366494 A CN102366494 A CN 102366494A CN 201110299239X A CN201110299239X A CN 201110299239XA CN 201110299239 A CN201110299239 A CN 201110299239A CN 102366494 A CN102366494 A CN 102366494A
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Abstract
The invention provides a Chinese patent medicine for treating hypercortisolism, which comprises the following components by weight part: 7-11 parts of radix bupleuri, 7-11 parts of Chinese angelica, 7-11 parts of radix angelicae, 7-11 parts of white peony root, 9-15 parts of Poria cocos,9-15 parts of rehmanniae radix, 9-15 parts of rhizoma alismatis, 4-8 parts of akebia stem, 7-11 parts of scutellaria, 2-4 parts of coptis, 7-11 parts of Jiao Shanwei and 4-8 parts of gentian. Compared with the prior art, the Chinese patent medicine of the present invention aims at internal disease of hypercortisolism, is capable of performing therapies with syndrome differentiation, and has the advantages of good curative effect, low cost, no toxicity, no side-effect and obvious effect. The traditional Chinese medicine composition treats both principal and secondary aspect of disease.
Description
Technical field
The present invention relates to a kind of Chinese medicine, more particularly, relate to a kind of Chinese patent medicine of treating hypercortisolism.
Background technology
Hypercortisolism (Cushing's syndrome) claim hypercortisolism (hvpercortisolism) or Cushing's syndrome again; Be by Different types of etiopathogenises cause with the high hydrocortisone mass formed by blood stasis clinical syndrome that is characteristic, mainly show as moon face, plethora appearance, central obesity, acne, purple striae, hypertension, secondary diabetes and osteoporosis etc.With central obesity, moon face, skin acne, purple striae, hirsutism, potential diabetes, hypertension disease crowd, sexual dysfunction and virilization etc. is a main clinical characteristics.Primary disease is more common in the women, and men and women's ratio is 1:2～1:3, and is in the majority with 20～40 years old age.Due to illness the primary disease prognosis differs greatly because of different, adrenal carcinoma or dystopy neoplasm metastasis person, and merge heart failure, cerebrovascular accident, uremia or severe infections person, prognosis mala.Hypercortisolism belongs to categories such as the traditional Chinese medical science " liver-yang ", " phlegm-damp ".Western medical treatment often adopts the hormone synthetic inhibitor, and like Metopirone, it suppresses, and 11-deoxidation hydrocortisone is converted into hydrocortisone, the 11-desoxycortone is converted into corticosterone, and hydrocortisone is synthetic to be reduced thereby make.But effect is temporary transient, can only play relief of symptoms, or Cyproheptadine, and it is the competitor of serotonin (serotonin), and serotonin can excited thalamus-hypophysis axle and discharge ACTH, secretes thyroliberin (ACTH) so Cyproheptadine can suppress hypophysis.But there is certain side effect in these medicines, expensive, and control table and do not effect a permanent cure.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese patent medicine of treating hypercortisolism, it is to the inherent pathogenic factor of hypercortisolism, distinguishes that disease executing control, and with strong points, curative effect is fast, and cost is low, and has no side effect, and can reach the effect of treating both the principal and secondary aspects of a disease.
The present invention adopts following technical scheme: a kind of Chinese patent medicine of treating hypercortisolism in weight portion, comprises following component: Radix Bupleuri 7-11, Radix Angelicae Sinensis 7-11; Rhizoma Atractylodis Macrocephalae 7-11, Radix Paeoniae Alba 7-11, Poria 9-15, Radix Rehmanniae 9-15; Rhizoma Alismatis 9-15, Caulis Akebiae 4-8, Radix Scutellariae 7-11; Rhizoma Coptidis 2-4, Jiaoshan Hill mast 7-11, Radix Gentianae 4-8.
The Analysis on Mechanism of Chinese medicine of the present invention:
Radix Bupleuri: hardship is slightly cold.Return Liver Channel, gallbladder meridian.Evacuation is brought down a fever, the yang invigorating soothing liver-QI.Be used for that cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia." medicine origin ": Radix Bupleuri, lack sun, faint cloudy guiding drug also.The medicine that the married woman must use antenatal puerperal also.The kind herbal classic of removing is had a headache, and non-this medicine can not end.
Radix Angelicae Sinensis: warm in nature, hide sweet, hot.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Materia Medica of Decoction: " Radix Angelicae Sinensis, few the moon of starting with, with its heart master blood also; It is lunar to go into foot, wraps up in blood also with its spleen; Go into the sufficient the moon of fainting, also with its blood stored in the liver.”
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; The stomach warp.Invigorating the spleen and benefiting QI; The dampness diuretic; Hidroschesis.Be used for deficiency-weakness of spleen-QI; Spiritlessness and weakness." herbal classic is met former ": the Rhizoma Atractylodis Macrocephalae, it is living that the expectorant diuretic is controlled anemofrigid-damp arthralgia with there being the dehumidifying benefit dry, dead flesh convulsion subcutaneous ulcer, the blood between the waist umbilicus that looses, reaching chong channel is disease, the merit of contrary gas pain in the abdomen; Making ripely then has and middle QI invigorating, slakes thirst and help produce saliva, and the hidroschesis heat extraction advances diet, antiabortive effect.
The Radix Paeoniae Alba: picric acid, cold.Go into liver, spleen channel.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant." herbal classic ": main pathogen stomachache, remove arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.
Poria: slightly sweet flavor is flat, goes into the heart, lung, spleen channel.Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming." herbal classic ": the contrary gas of the main breast side of body, melancholy is angerd frightened heresy and is probably throbbed with fear, and the heart is the knot pain down, cold and heat stuffy sensation with restlessness, cough with dyspnea, mouthful burnt dry tongue, diuresis.
The Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
Rhizoma Alismatis: sweet in the mouth; Light; Cold in nature.Return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen; It is treating stranguria to expel the heat-evil.Main dysuria; The puckery pain of pyretic stranguria; The edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission." detailed outline ": Rhizoma Alismatis, gas is flat, and sweet in the mouth is and light, and light can oozing let out, and abnormal smells from the patient is all thin, so diuretic and diarrhea.
Caulis Akebiae: bitter, be slightly cold.Go into heart channel, small intestine meridian, urinary bladder channel.Clearing away heart-fire, diuresis, the stimulating milk secretion of stimulating the menstrual flow.Be used for irritable feverish sensation in the chest, the sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, the amenorrhea breast is few." property of medicine opinion ": cure mainly five types of stranguria, diuresis, the switch lattice are controlled the people and are slept more, and main edema is floating big, heat clearing away and restlessness relieving.
Radix Scutellariae: hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement." detailed outline ": control the damp and hot headache of wind heat, renal mass burning pain, cough caused by pathogenic fire, consumptive lung disease larynx, all losing blood.
Rhizoma Coptidis: hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.
The Jiaoshan Hill mast: hardship, cold.Go into the heart, liver, lung, stomach warp.Heat clearing away, pathogenic fire purging, removing heat from blood.Control the calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea is quenched one's thirst, conjunctival congestion, pharyngalgia is spitted blood, epistaxis, dysentery, hematuria, pathopyretic ulcer is sprained and is swollen and ache." herbal classic ": pathogen in main five, pathogenic heat in the stomach gas, flushed complexion, wine bleb Zha nose, tuberculoid leprosy, red leprosy, skin infection.
Radix Gentianae: bitter in the mouth, cold in nature.Return liver, gallbladder meridian.Heat clearing and damp drying, the eliminating pathogen in the liver arresting convulsion." book on Chinese herbal medicine just ": Radix Gentianae is the positive medicine of the sufficient the moon of fainting, few sun, and ability pathogenic fire purging greatly makes but regard it as assistant, then all controls at fire.The fire that all Liver and kidney are had a surplus, all its institute is suitable.
The traditional Chinese medical science thinks that the cause of disease of hypercortisolism is unsuccessful by feelings will, overstrain impairing the spleen, and stagnation of liver-QI with deficiency of the spleen, due to giving birth in damp and hot, or because of the diseases caused by exogenous pathogenic factor six climate exopathogens, damp and hot combined pathogens is for suffering from, and then the fire-transformation impairment of YIN, final deficiency of YIN affecting YANG, deficiency of both YIN and YANG.Body deficiency of YIN-blood person also is always or usually as specified.
Pathological change is angry impairing the liver, and liver is lost bar and reaches, and liver insulting spleen, or overstrain impairing the spleen, all causes damage of spleen-QI.Spleen is soil between two parties, main transmitting and distributing the fluids.Stagnation of liver-QI with deficiency of the spleen, the damp-stagnancy heat-transformation, damp and hot interior the Sheng is so see thoracic dorsal obesity, moon face, skin acne.Damp and hot fire-transformation decocts Tianjin blood, and Tianjin blood all loses, and spleen governing limbs, insufficiency of the spleen mistake fortune, and the essence and blood extremity of can not supplementing nutrition, then extremity are become thin unable.With the passing of time qi and blood stagnation becomes the stasis of blood, overflows and then sees purple striae in skin.Disease can cause hepatic and renal YIN deficiency for a long time, and hyperactivity of YANG due to deficiency of YIN is then sent out dizzy.Final deficiency of YIN affecting YANG causes deficiency of both YIN and YANG, and body and the spirit two declines.
To the hypercortisolism due to the liver dampness-heat in the spleen, the traditional Chinese medical science is thought spleen soil between two parties, main transmitting and distributing the fluids.Depression of liver-QI, liver insulting spleen, damage temper, insufficiency of the spleen damp-stagnancy, the phlegm-damp inner product, then thoracic dorsal is fat; The damp-stagnancy heat-transformation, damp and hot interior the Sheng then seen moon face, and face is glossy, and acne takes place frequently; Damp and hot fire-transformation decocts essence and blood, and essence and blood all loses, and extremity lose in essence and blood and supplement nutrition, and it is weak then to become thin; Blood deficiency and the stasis of blood, then skin purple striae; Flaming up of liver-fire, then impatient irritability, dry mouth with bitter taste; Become under damp and hot, it is viscid not well then to defecate, yellowish or reddish urine; Red tongue, yellow and greasy fur, the stringy and rolling pulse number is the liver spleen and becomes estranged, damp and hot interior levying of containing.
The person of choosing in the side, soothing liver and strengthening spleen, clearing away heat and eliminating dampness, with Radix Bupleuri yang invigorating soothing liver-QI, Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying, the Poria invigorating the spleen and regulating the stomach, three medicine compatibilities are monarch drug; Be aided with Radix Rehmanniae clearing away heat and cooling blood, the Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, Caulis Akebiae, Jiaoshan Hill mast clearing away heat-fire, Radix Scutellariae, Rhizoma Coptidis, Radix Gentianae heat clearing and damp drying, mutual reinforcement between is a usefulness, is minister altogether, to help the merit of soothing liver and strengthening spleen; Assistant is managed yin fluid astringing jointly with the Radix Paeoniae Alba; Make when being classified as, enrich blood and invigorate blood circulation.Full side is the long memorial liver spleen altogether, and Qinghua heat is wet, balance body negative and positive.To the hypercortisolism determined curative effect, effect is remarkable, double taking stopgap measures originally.
Form of Chinese drug of the present invention can adopt tablet, granule, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid, powder.Preferably, can adopt solution, granule, pill and capsule.
Result of use
Diagnostic criteria:
1, central obesity demonstrates central obesity, i.e. trunk fertilizer and extremity are thin;
2, moon face is looked like full moon, and ruddy greasiness;
3, buffalo hump, back are " buffalo hump " apperances, and abdominal part dangles;
4, purple striae also has purple striae in addition, and purple striae is more common in the skin of the outside, buttocks in stomach wall, the thigh;
5, property aspect, sexual hypofunction, impotence, testis deliquescing, women's spanomenorrhea, amenorrhea, sterile, hirsutism;
6, skeletal system, lumbago and backache, compression fracture of spine appear in visible osteoporosis, and the later stage can form hunchback because of collapse of vertebra.
The curative effect judgment criteria:
1. recovery from illness: central obesity transference cure;
2. effective: central obesity remission, transference cures such as purple striae, acne, hirsutism;
3. invalid: above-mentioned symptom does not have obvious change.
To the Chinese patent medicine of 40 hypercortisolism patients (age 25-40) use treatment hypercortisolism of the present invention, 1 course of treatment of continued treatment (2 week), wherein 14 examples are cured fully, transference cure; 23 routine symptoms are obviously alleviated, and join fat remission, and purple striae, acne symptom disappear; Invalid 3 examples, overall effective percentage reaches 92.5%.Treatment has no side effect, routine test, hepatic and renal function inspection no abnormality seen.
Instance:
The patient 1: Chen, and the women, 33 years old, obesity, the slight edema of whole body, xerosis cutis, and easy subcutaneous hemorrhage, weak, feeling of fatigue is often arranged, pause work, just gas can not continue.1 course of treatment of Chinese patent medicine of the present invention is used in the back, remission, and edema disappears, and urinary function is normal, symptoms such as purple striae, acne do not occur, and the xerosis cutis sense disappears.
The patient 2: soup, and the women, 30 years old, existing central obesity, facial greasiness, purple striae appears in femoribus internus, typical hypercortisolism symptom.Use Chinese patent medicine of the present invention after 1 course of treatment, purple striae disappears, and facial oil alleviates.The improvement continued was taken medicine 2 months, and obesity symptom alleviates, and no longer was central obesity, and it is well-balanced that the figure recovers basically.
The patient 3: season, and the male, 27 years old, edema the companion became thin, and face is round, acne is serious, abdominal part purple striae, hypercortisolism classical symptom.Take 1 course of treatment of Chinese patent medicine of the present invention, the beginning produce effects, at first the edema of face alleviates, and acne alleviates, and continues 1 course of treatment of treatment, and acne all disappears, and face also becomes thin, and it is normal that the figure recovers.
The specific embodiment
In order to understand the present invention better, through embodiment the present invention is described below.
Embodiment 1
A kind of Chinese patent medicine of treating hypercortisolism in weight portion, comprises following component: Radix Bupleuri 7, Radix Angelicae Sinensis 7, the Rhizoma Atractylodis Macrocephalae 7, the Radix Paeoniae Alba 7, Poria 9, the Radix Rehmanniae 9, Rhizoma Alismatis 9, Caulis Akebiae 4, Radix Scutellariae 7, Rhizoma Coptidis 2, Jiaoshan Hill mast 7, Radix Gentianae 4.
Its preparation method is:
In weight portion, get Radix Bupleuri 7, Radix Angelicae Sinensis 7, the Rhizoma Atractylodis Macrocephalae 7, the Radix Paeoniae Alba 7, Poria 9, the Radix Rehmanniae 9, Rhizoma Alismatis 9, Caulis Akebiae 4, Radix Scutellariae 7, Rhizoma Coptidis 2, Jiaoshan Hill mast 7, Radix Gentianae 4; Above-mentioned Chinese medicine is cleaned, and decontamination is put into container and is added water and do not have medical material to soak, and after 30 minutes, big fire decocts to boiling, and slow fire was endured 1 hour slowly then; Medicine juice is leached, bag distribution packaging, one bag of 200ml sooner or later respectively obey one bag, but the dual-purpose medicinal liquid is smeared affected part.
Embodiment 2
A kind of Chinese patent medicine of treating hypercortisolism in weight portion, comprises following component: Radix Bupleuri 11, Radix Angelicae Sinensis 11, the Rhizoma Atractylodis Macrocephalae 11, the Radix Paeoniae Alba 11, Poria 15, the Radix Rehmanniae 15, Rhizoma Alismatis 15, Caulis Akebiae 8, Radix Scutellariae 11, Rhizoma Coptidis 4, Jiaoshan Hill mast 11, Radix Gentianae 8.
Its preparation method is:
In weight portion, get Radix Bupleuri 11, Radix Angelicae Sinensis 11, the Rhizoma Atractylodis Macrocephalae 11, the Radix Paeoniae Alba 11, Poria 15, the Radix Rehmanniae 15, Rhizoma Alismatis 15, Caulis Akebiae 8, Radix Scutellariae 11, Rhizoma Coptidis 4, Jiaoshan Hill mast 11, Radix Gentianae 8; Cleaning, drying mix above-mentioned medical material, and per kilogram adds about 10L water, and 0.5-1 at a simmer hour, big fire was fried in shallow oil 1-2 hour; Get decocting liquid and cross 150 mesh sieves, the back is concentrated into the clear paste of relative density 1.10-1.20 with concentrator, gets 2/3 clear paste 120 ℃ of following spray dryinges, the clear paste powder, powder is mixed granulation with residue 1/3 clear paste; The packing of granule racking machine promptly gets granule.
Embodiment 3
A kind of Chinese patent medicine of treating hypercortisolism in weight portion, comprises following component: Radix Bupleuri 9, Radix Angelicae Sinensis 9, the Rhizoma Atractylodis Macrocephalae 9, the Radix Paeoniae Alba 9, Poria 12, the Radix Rehmanniae 12, Rhizoma Alismatis 12, Caulis Akebiae 6, Radix Scutellariae 9, Rhizoma Coptidis 3, Jiaoshan Hill mast 9, Radix Gentianae 6.
Its preparation method is:
In weight portion, get Radix Bupleuri 9, Radix Angelicae Sinensis 9, the Rhizoma Atractylodis Macrocephalae 9, the Radix Paeoniae Alba 9, Poria 12, the Radix Rehmanniae 12, Rhizoma Alismatis 12, Caulis Akebiae 6, Radix Scutellariae 9, Rhizoma Coptidis 3, Jiaoshan Hill mast 9, Radix Gentianae 6; Cleaning, drying mix above-mentioned medical material, use pulverizer to pulverize and are 150-180 order fine powder, and add suitable Mel and mix, the pellet processing machine pill, cold drying, packing promptly gets pill.
Embodiment 4
A kind of Chinese patent medicine of treating hypercortisolism in weight portion, comprises following component: Radix Bupleuri 9, Radix Angelicae Sinensis 9, the Rhizoma Atractylodis Macrocephalae 9, the Radix Paeoniae Alba 9, Poria 12, the Radix Rehmanniae 12, Rhizoma Alismatis 12, Caulis Akebiae 6, Radix Scutellariae 9, Rhizoma Coptidis 3, Jiaoshan Hill mast 9, Radix Gentianae 6.
Its preparation method is:
In weight portion, get Radix Bupleuri 9, Radix Angelicae Sinensis 9, the Rhizoma Atractylodis Macrocephalae 9, the Radix Paeoniae Alba 9, Poria 12, the Radix Rehmanniae 12, Rhizoma Alismatis 12, Caulis Akebiae 6, Radix Scutellariae 9, Rhizoma Coptidis 3, Jiaoshan Hill mast 9, Radix Gentianae 6; Cleaning, drying mix above-mentioned medical material, and per kilogram adds about 10L water, and 0.5-1 at a simmer hour, big fire was fried in shallow oil 1-2 hour; Get decocting liquid and cross 150 mesh sieves, the back is concentrated into the clear paste of relative density 1.10-1.20 with concentrator, gets 2/3 clear paste 120 ℃ of following spray dryinges, the clear paste powder, powder is mixed granulation with residue 1/3 clear paste; Granule is processed the 0.4g/ capsules with the capsule filler.
Claims (4)
1. a Chinese patent medicine of treating hypercortisolism is characterized in that, in weight portion, comprises following component: Radix Bupleuri 7-11, Radix Angelicae Sinensis 7-11; Rhizoma Atractylodis Macrocephalae 7-11, Radix Paeoniae Alba 7-11, Poria 9-15, Radix Rehmanniae 9-15, Rhizoma Alismatis 9-15; Caulis Akebiae 4-8, Radix Scutellariae 7-11, Rhizoma Coptidis 2-4, Jiaoshan Hill mast 7-11, Radix Gentianae 4-8.
2. Chinese patent medicine according to claim 1 is characterized in that, in weight portion, preferably comprises following component: Radix Bupleuri 9, Radix Angelicae Sinensis 9, the Rhizoma Atractylodis Macrocephalae 9, the Radix Paeoniae Alba 9, Poria 12, the Radix Rehmanniae 12, Rhizoma Alismatis 12, Caulis Akebiae 6, Radix Scutellariae 9, Rhizoma Coptidis 3, Jiaoshan Hill mast 9, Radix Gentianae 6.
3. Chinese patent medicine according to claim 1 is characterized in that, said Chinese patent medicine adopts tablet, granule, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid, powder.
4. Chinese patent medicine according to claim 1 is characterized in that said Chinese patent medicine preferably adopts solution, granule, pill and capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306680A (en) * | 2014-09-28 | 2015-01-28 | 四川金堂海纳生物医药技术研究所 | Internal medicine for treating Cushing syndrome and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306680A (en) * | 2014-09-28 | 2015-01-28 | 四川金堂海纳生物医药技术研究所 | Internal medicine for treating Cushing syndrome and preparation method thereof |
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Application publication date: 20120307 |