CN102366465A - Sanhuangqingjie pharmaceutical composition and preparation method thereof - Google Patents

Abstract

The invention which discloses a Sanhuangqingjie pharmaceutical composition and a preparation method thereof relates to the field of traditional Chinese medicines. The Sanhuangqingjie pharmaceutical composition comprises Coptis chinensis, Radix Scutellariae, Amur Corktree Bark, honeysuckle flower and Weeping Forsythia. The Sanhuangqingjie pharmaceutical composition which has a main effect of heat clearing and detoxifying can be used for treating symptoms of wind warm cold, fever, cough and asthma, serious aphtha, heat strangury, diarrhea, and the like.

Description

A kind of Sanhuang Qingjie pharmaceutical composition and preparation method thereof

Technical field

The present invention relates to tcm field, be specifically related to Sanhuang Qingjie pharmaceutical composition of a kind of heat-clearing and toxic substances removing and preparation method thereof.

Background technology

At present, mostly " Sanhuang Qingjie " named with Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri three flavor principal agents is tablet.Tablet is as a kind of traditional dosage form; Because of its steady quality, dosage accurately, take, easy to carry, mechanization degree is high, production cost is low and become one of at present the most frequently used dosage form, but because of the tablet extrusion forming; Disintegrate is slower; Bioavailability is lower, and the part patient difficulty of swallowing comparatively, thereby promoting the use of to a certain extent of tablet is restricted.Capsule then exists: can cover adverse drug and smell flavor or improve medicine stability; Bioavailability of medicament is higher; Can remedy the deficiency of other solid dosage formss; Can delay the release of medicine and the advantage of positioning release medicine.Be isolated from the outside because of medicine is contained in the capsule shells, avoided the influence of moisture, air, light, bad flavor or the unsettled medicine smelt of tool had covering to a certain extent, protection and Stabilization.Medicine in the capsule is directly to load in softgel shell with powder or graininess, the influence of factor such as be not stressed, so dispersion rapidly, stripping and absorption in gastrointestinal tract, its bioavailability will be higher than pill, tablets and other formulations.Medicine that oil content is high or liquid drug are difficult to process pill, tablet etc., but can be made into soft capsule.Can medicine be processed during slow-releasing granules incapsulates on demand, reach the effect of slow release prolongation of effect, the contac capsule promptly belongs to this type; Process enteric coated capsule and can the medicine location be released to small intestinal for absorption, also can be made into the capsule of rectally or vagina administration, make to be positioned at these tract releases; To absorb protide, polypeptide drug preferably at colonic segment, can be made into segmented intestine targeted capsule.

Summary of the invention

The invention provides Sanhuang Qingjie pharmaceutical composition of a kind of heat-clearing and toxic substances removing and preparation method thereof.

A kind of Sanhuang Qingjie pharmaceutical composition that the present invention proposes and preparation method thereof is processed by the raw material of Chinese medicine of following weight ratio: Rhizoma Coptidis 60-80 part; Radix Scutellariae 50-150 part; Cortex Phellodendri 60-80 part; Flos Lonicerae 100-200 part; Fructus Forsythiae 100-200 part.

Among the present invention, described a kind of Sanhuang Qingjie pharmaceutical composition and preparation method thereof, a preferred version is for to be processed by the raw material of Chinese medicine of following weight ratio: 67 parts of Rhizoma Coptidis; 100 parts of Radix Scutellariaes; 67 parts of Cortex Phellodendris; 133 parts of Flos Loniceraes; 133 parts of Fructus Forsythiaes.

Among the present invention, described a kind of Sanhuang Qingjie pharmaceutical composition and preparation method thereof is an oral formulations.

The Rhizoma Coptidis bitter in the mouth; Cold in nature, nontoxic; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Cure mainly heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.Be used for conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.Be used for incoordination between the liver and stomach, the vomiting acid regurgitation.

The Radix Scutellariae bitter in the mouth; Cold in nature; Return lung, gallbladder, spleen, large intestine, small intestine meridian.Cure mainly heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Heat clearing and damp drying is arranged, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Be used for hygropyrexia heating, uncomfortable in chest, feeling thirst but no desire to drink, and diseases such as damp-heat dysentery, jaundice.To the hygropyrexia heating, with fit applications such as Talcum, roud cardamon seed, Poria; To damp-heat dysentery, stomachache, be equal to usefulness with the Radix Paeoniae Alba, Radix Puerariae, Radix Glycyrrhizae; Jaundice for due to the damp-heat accumulation can be equal to usefulness with Herba Artemisiae Scopariae, Fructus Gardeniae, Herba Lophatheri.Be used for calentura hyperpyrexia excessive thirst, or the cough due to lung-heat, or the intenseness of heat forcing blood is excessive and pathopyretic ulcer etc.Control the calentura hyperpyrexia, compatibilities such as normal and Rhizoma Coptidis, Fructus Gardeniae; Control the cough due to lung-heat, can be equal to usefulness with the Rhizoma Anemarrhenae, Cortex Mori; Control bleeding due to blood-heat, can be equal to usefulness with the Radix Rehmanniae, Cortex Moutan, Cacumen Platycladi; To pathopyretic ulcer, can use together with medicines such as Flos Lonicerae, Fructus Forsythiaes.In addition, these article have the clearing heat and preventing abortion effect again, can be used for frequent fetal movement, fit applications such as the normal and Rhizoma Atractylodis Macrocephalae, Caulis Bambusae In Taenia.

The Cortex Phellodendri bitter in the mouth; Cold in nature; Return kidney, bladder, large intestine channel.Cure mainly heat clearing and damp drying, eliminating fire and detoxication removes the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.The main component of Cortex Phellodendri bark is a berberine, and other contains multiple alkaloids such as phellodendrine, magnoflorine, jateorhizine, palmatine, candicine, Dauricine.In addition, still contain obakulactone, obacunone, obacunonic acid and 7-dehydrogenation stigmasterol, cupreol, campesterol, the acid of blue or green fluorescent, Dictamnolide.The wampee bark contains multiple alkaloid such as berberine, magnoflorine, phellodendrine, palmatine and lactone, sterol, lymphatic temperament etc.

The Flos Lonicerae sweet in the mouth; Cold in nature; Attach to the lung and stomach meridians.Cure mainly heat-clearing and toxic substances removing.The epidemic febrile disease heating; Toxic-heat and blood stasis; The carbuncle furuncle; Sore throat and multiple infectious disease.The peculiar effect of Flos Lonicerae is: resisting pathogenic microbes effect: various pathogens such as staphylococcus aureus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi etc. are all had certain inhibitory action; Have antibacterial and bactericidal action to streptococcus pneumoniae, meningococcus, bacillus pyocyaneus, tubercule bacillus, dysentery bacterium, Streptococcus mutans etc., influenza virus, Orphan virus, herpesvirus, leptospira are all had inhibitory action; Anti inflammatory detoxication effect: carbuncle furuncle, acute appendicitis lung abscess are had stronger diffusing carbuncle detumescence, heat-clearing and toxic substances removing, antiinflammation; Dredge the heat evil effect of loosing: to affection due to external wind and heat or epidemic febrile disease from the beginning of, fever of the body headache, vexedly sleep less, coma crimson tongue, dry mouth and throat etc. have certain effect; Eliminating pathogenic heat from blood to cure dysentery effect: the effect that pyretic toxicity dysentery, dysentery pus and blood, hygropyrexia resistance larynx, laryngopharynx swelling and pain etc. is had detoxifcation dysentery relieving removing heat from blood sore-throat relieving.

The Fructus Forsythiae bitter in the mouth; Cold nature; Return lung, the heart, small intestine meridian.Cure mainly heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens has the title of " persons particularly liable to develop skin infection's panacea ".Control warm, erysipelas, macule, the carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction, clearing away heart-fire.Fructus Forsythiae is the Chinese medicine of heat-clearing and toxic substances removing, cures mainly calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain, acute nephritis etc.

Among the present invention, described a kind of Sanhuang Qingjie pharmaceutical composition and preparation method thereof, described method for preparing process following steps,

1. take by weighing the raw material of Chinese medicine of said part by weight, Rhizoma Coptidis, Radix Scutellariae powder are broken into fine powder, it is subsequent use to sterilize;

2. with Fructus Forsythiae, Flos Lonicerae decocte with water secondary, add 12 times of water gagings for the first time and decocted 1.5 hours, add 10 times of water gagings for the second time and decocted 1 hour; Cortex Phellodendri decocte with water secondary adds 12 times of water gagings for the first time and decocted 2 hours, and the decocting that adds 10 times of amounts for the second time boiled 2 hours; Merge above-mentioned decoction liquor, filter, filtrate decompression concentrate (70-75 ℃ ,-0.075MPa) to the thick paste of relative density 1.30-1.35 (50 ℃), add above-mentioned Rhizoma Coptidis, Baical Skullcap Root, mixing, drying under reduced pressure is ground into fine powder, crosses 100 mesh sieves, and is subsequent use;

3. with above-mentioned fine powder be prepared into suitable oral formulations after other pharmaceutic adjuvants mix.

Among the present invention, described a kind of Sanhuang Qingjie pharmaceutical composition and preparation method thereof, a preferred oral preparation formulation is a capsule.

Among the present invention, described a kind of Sanhuang Qingjie pharmaceutical composition cures mainly heat-clearing and toxic substances removing, is used for the pathogenic wind-warm calentura, the heating cough with asthma, and the aphtha flame is swollen, diseases such as pyretic stranguria dysentery.

Usage: oral, the 6-8 grain of being grown up a time; Child eight years old to 14 years old, a 4-6 grain; Four years old to seven years old, a 3-4 grain; One-year-old to three years old, the 1-2 grain.Not one year old children's is cut down according to the circumstance.

The specific embodiment

Below in conjunction with embodiment a kind of Sanhuang Qingjie pharmaceutical composition of the present invention and preparation method thereof is described.

Embodiment 1.

Among the present invention, described a kind of Sanhuang Qingjie pharmaceutical composition and preparation method thereof, described method for preparing process following steps,

1. take by weighing the raw material of Chinese medicine of said part by weight, Rhizoma Coptidis 67g, Radix Scutellariae 100g, Cortex Phellodendri 67g are ground into fine powder, it is subsequent use to sterilize;

2. with Fructus Forsythiae 133g, Flos Lonicerae 133g decocte with water secondary, add 12 times of water gagings for the first time and decocted 1.5 hours, add 10 times of water gagings for the second time and decocted 1 hour; Cortex Phellodendri decocte with water secondary adds 12 times of water gagings for the first time and decocted 2 hours, and the decocting that adds 10 times of amounts for the second time boiled 2 hours; Merge above-mentioned decoction liquor, filter, filtrate decompression concentrate (70-75 ℃ ,-0.075MPa) to the thick paste of relative density 1.30-1.35 (50 ℃), add above-mentioned Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri powder, mixing, drying under reduced pressure is ground into fine powder, crosses 100 mesh sieves, and is subsequent use;

3. above-mentioned fine powder is mixed the back granulate with other pharmaceutic adjuvants, filled capsules is processed 1000, both.

Case.

Liu, the man, 42 years old, the heating cough with asthma, treat through this medicine in June, 2010, after 3 days, rehabilitation.

The Wang, the woman, 27 years old, the aphtha pharyngeal swelling, treat through this medicine in January, 2010, after 5 days, rehabilitation.

The above; Be merely the preferable specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technical staff who is familiar with the present technique field is equal to replacement or change according to technical scheme of the present invention and inventive concept thereof in the technical scope that the present invention discloses, all should be encompassed within protection scope of the present invention.

Claims (5)

1. Sanhuang Qingjie pharmaceutical composition, it is characterized in that: the raw material of Chinese medicine by the following weight ratio is processed: Rhizoma Coptidis 60-80 part; Radix Scutellariae 50-150 part; Cortex Phellodendri 60-80 part; Flos Lonicerae 100-200 part; Fructus Forsythiae 100-200 part.

2. a kind of Sanhuang Qingjie pharmaceutical composition according to claim 1, it is characterized in that: the raw material of Chinese medicine by the following weight ratio is processed: 67 parts of Rhizoma Coptidis; 100 parts of Radix Scutellariaes; 67 parts of Cortex Phellodendris; 133 parts of Flos Loniceraes; 133 parts of Fructus Forsythiaes.

3. a kind of Sanhuang Qingjie pharmaceutical composition according to claim 2 is characterized in that: be oral formulations.

4. a kind of Sanhuang Qingjie preparation of drug combination method according to claim 1 is characterized in that: described method for preparing process following steps,

1. take by weighing the raw material of Chinese medicine of said part by weight, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri powder are broken into fine powder, it is subsequent use to sterilize;

2. with Fructus Forsythiae, Flos Lonicerae decocte with water secondary, add 12 times of water gagings for the first time and decocted 1.5 hours, add 10 times of water gagings for the second time and decocted 1 hour; Cortex Phellodendri decocte with water secondary adds 12 times of water gagings for the first time and decocted 2 hours, and the decocting that adds 10 times of amounts for the second time boiled 2 hours; Merge above-mentioned decoction liquor, filter, filtrate decompression concentrate (70-75 ℃ ,-0.075MPa) to the thick paste of relative density 1.30-1.35 (50 ℃), add above-mentioned Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri powder, mixing, drying under reduced pressure is ground into fine powder, crosses 100 mesh sieves, and is subsequent use;

3. with above-mentioned fine powder be prepared into suitable oral formulations after other pharmaceutic adjuvants mix.

5. a kind of Sanhuang Qingjie pharmaceutical composition according to claim 4 and preparation method thereof is characterized in that: a preferred oral preparation formulation is a capsule.