CN102357069A - Natural active cosmetic and its preparation method and use - Google Patents
Natural active cosmetic and its preparation method and use Download PDFInfo
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- CN102357069A CN102357069A CN2011103208525A CN201110320852A CN102357069A CN 102357069 A CN102357069 A CN 102357069A CN 2011103208525 A CN2011103208525 A CN 2011103208525A CN 201110320852 A CN201110320852 A CN 201110320852A CN 102357069 A CN102357069 A CN 102357069A
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Abstract
The invention relates to a natural active cosmetic and its preparation method and use. The natural active cosmetic is a beauty treatment product prepared mainly from traditional traditional Chinese medicines of soybean, Chinese yam, dahurian angelica root, bighead atractylodes rhizome, white peony root and Indian buead as active components. The natural active cosmetic has the effects of whitening, removing wrinkles, delaying skin aging, and preventing and improving the skin problems of chromatosis, blacking, yellowing, darkness, chloasma, sunburn, cyasma, acne scars, cutis laxa and fine wrinkles.
Description
Technical field
The present invention relates to a kind of natural activity cosmetics; In particular; Be a kind of be the cosmetic composition that active component is prepared from the natural product; Further say; Be the cosmetic composition that mainly uses the Chinese medicine material to be prepared from as active component, particularly relate to whiten, wrinkle removing, anti aging effect and prevention and improve cosmetic compositions such as skin problem such as pigmentation, black, yellow, dark yellow, chloasma, sunburn, cyasma, pox seal, cutis laxa, fine wrinkle.
Background technology
The natural activity cosmetics are meant through fine chemistry industry, biotechnology, the cosmetics of processing after will having unique function and a bioactive chemical compound extraction separation coming out from natural material (like Chinese herbal medicine, animal organ, sea-plant and microorganism etc.).Mainly contain the following aspects: natural animal-plant extracting solution, microbial fermentation product, genetically engineered biological preparation, other biochemically active compositions etc.
Wherein natural animal-plant becomes increasingly active as the research of cosmetic active ingredient; " BAICAO all can be used as medicine " is used for cosmetics with the natural animal-plant extracting solution and can plays good treatment and skin protection double effects; The U.S. and Japan are used for cosmetics with more than 100 kinds of natural botanical extraction liquids, like crude vegetal (essence, skin protection), Aloe extract (antibacterial, whiten), green tea extract (antioxidation, defying age), Semen Ginkgo extrac (removing oxygen-derived free radicals), Semen Vitis viniferae extract (removing oxygen-derived free radicals), Semen Tritici aestivi extract (aging resistance), Sargassum extract (remove free radical, aging resistance, preserve moisture, sun-proof, fat-reducing), Placenta Hominis extract (crease-resistant, defying age), collagen protein (crease-resistant, defying age) etc.China should say so in the application facet of natural plants has attainments very much, and Chinese herbal medicine is the marrow of China's medicine, and there is advantageous advantage in China aspect Chinese herbal medicine extract.
The natural activity cosmetics are new problems in the present age, and it relates to multiple subjects such as chemical, biochemistry, pharmacology, skin science, botany, middle medical chemistry, cosmetic science.The reasons such as complexity, unstability and price height of natural active matter (like Chinese herbal medicine) composition hamper the development of natural activity cosmetics always.How never with seek in the combination of natural active substance can maximized performance combined effect compositions be to need the matter of utmost importance that solves.Secondly, how extraction separation goes out effective ingredient and makes the extract stabilisation from the Chinese medicine ingredients of complicacy, and the price that reduces the natural activity thing also is the key of R and D natural activity cosmetics.
The natural activity cosmetics of being paid close attention at present have the osajin that from Semen sojae atricolor, Radix Puerariae, extracts, the hesperidin that from the citrus peel slag, extracts, plant anthocyan, propolis extract etc.; But; They all are that above-mentioned active skull cap components is distinctly used usually; Be equipped with cosmetic field emulsifying agent commonly used, surfactant, wetting agent or the like raw material and process the single cosmetics of active component, its effect relatively a little less than, or have certain side effect.Not through the combination and compatibility of multiple active skull cap components, produce and coordinate compatibility effect, maximized performance active skull cap components effect.
Face pack be with skin preserve moisture and cleaning etc. is purpose and widely used cosmetics, peel-away type, obliterating are arranged or rub according to the difference of method for using and wash type, paste several kinds of types etc.Wherein can add adjuvants such as wetting agent, oil content, fruit glaze agent such as polyvinyl alcohol, vinyl acetate Emulsion, xanthan gum, carbopol, polyvinylpyrrolidone, synthetic cellulose family macromolecule chemical compound in a large number.
The technology of preparing of cosmetics is ripe relatively; As can adopt " department of dermatologry external preparation and its cosmetics formulary " (Chinese-language publishing house; 1996.2; Li Tienan etc.), " cosmetics-principle. prescription. production technology " (Chemical Industry Press, 1999.8, Wang Peiyi) wait routine techniques and the conventional adjuvant put down in writing in books or other prior aries such as teaching material, reference book, patent, the periodicals and magazines to prepare cosmetics.
Summary of the invention
The object of the invention provides a kind of natural activity cosmetics; Wherein has multiple active skull cap components; Can bring into play whiten, wrinkle removing, anti aging effect effect, and prevention and improve skin problems such as pigmentation, black, yellow, dark yellow, chloasma, sunburn, cyasma, pox seal, cutis laxa, fine wrinkle.
Main purpose of the present invention is to provide the composition and the proportioning of active skull cap components in the said natural activity cosmetics, with and extract method for preparing.After obtaining active skull cap components, can adopt the conventional cosmetics method for preparing in this area to be prepared as cosmetics,, be more especially facial film like conventionally form, particularly unguentum, Emulsion and facial films such as cream, Emulsion, powder, unguentum, lotion, aerosol, facial films.
Concrete technology of preparing can prepare cosmetics with reference to routine techniques and the conventional adjuvant put down in writing in the teaching material of this area, reference book, patent, the periodicals and magazines.As can adopt " department of dermatologry external preparation and its cosmetics formulary " (Chinese-language publishing house; 1996.2, Li Tienan etc.), " cosmetics-principle. prescription. production technology " (Chemical Industry Press, 1999.8; The technical scheme that Wang Peiyi) waits books to put down in writing; Also can adopt adjuvant and method, also can adopt " beauty treatment new technique new trend " (Chinese medical apparatus information, 2007 years like record among one Chinese patent application CN1242695A, the CN1244787 etc.; 13 1 phases of volume, 40-41,48 pages) in the technology and the method for record.Above-mentioned prior art is incorporated herein by reference at this in full.
Equally also can the active skull cap components that obtain directly directly be made up with commercially available cosmetics and obtain; Obtain as said active skull cap components is directly mixed with commercially available olay facial film, or the surface that said active skull cap components directly is coated in stickup type facial film is obtained.
Said active skull cap components is prepared from following materials of weight proportions medicine:
Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8 Radix Paeoniae Alba 5-9
Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7
More specifically, described Poria can be a Poria.
Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8 Radix Paeoniae Alba 5-9
Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7
More specifically, described Radix Panacis Quinquefolii can substitute with Radix Ginseng, Korean Ginseng, the Radix Pseudostellariae of equivalent or equal effect.
More specifically, can also contain Semen sojae atricolor in the described crude drug
Semen sojae atricolor 22-28 Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8 Radix Paeoniae Alba 5-9
Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7
More specifically, said Semen sojae atricolor is a Semen Glycines.
More specifically, can also contain brown sugar in the described crude drug,
Brown sugar 12-20 Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8 Radix Paeoniae Alba 5-9
Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7
More specifically, can also contain Radix Glycyrrhizae in the described crude drug,
Radix Glycyrrhizae 3-6 Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8 Radix Paeoniae Alba 5-9
Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7
More specifically, can also contain mealy potato in the described crude drug.
Mealy potato 23-28 Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8 Radix Paeoniae Alba 5-9
Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7
Said mealy potato is the mealy potato that Rhizoma Solani tuber osi obtains through steps such as super-dry, pulverizing.Certainly, also can be the potato starch that Rhizoma Solani tuber osi obtains through the conventional preparation in this area starch prepared.Simultaneously, those skilled in the art obviously be further appreciated that direct use equivalent or etc. the Rhizoma Solani tuber osi of effect directly as crude drug.
Simultaneously, except above-mentioned a kind of situation that can also contain in Semen sojae atricolor, brown sugar, Radix Glycyrrhizae, the mealy potato, can also contain in Semen sojae atricolor, brown sugar, Radix Glycyrrhizae, the mealy potato two or more in the said crude drug.
Concrete as:
Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7
Concrete as:
Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7
Concrete as:
Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7 mealy potato 23-28
Concrete as:
Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7
Concrete as:
Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7 mealy potato 23-28
Concrete as:
Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7 mealy potato 23-28
Concrete as:
Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7
Concrete as:
Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7 mealy potato 23-28
Concrete as:
Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7 mealy potato 23-28
Concrete as:
Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7 mealy potato 23-28
Concrete as:
Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7 mealy potato 23-28
This natural activity cosmetics can strengthen cell metabolism fast, blood circulation promoting, and safety speckle dispelling in the skin protection Glycerin makes delicate moist, the smooth exquisiteness of skin, compacts.
This natural activity cosmetics are effective ingredient and/or the filmogens that utilize the cuisines on the dining table in Chinese herbal medicine and our daily life; Organic dissolving is applied to face after mixing with other substrate; On skin, form a skim or not film forming covering, thereby reach skin protection, preserve moisture, clean, treat effect such as skin.Give an example and non-limiting, when it processed facial film, the full-natural nutritive facial film was nutritious, and preserving moisture and protecting skin is effective.Because it is that natural plants is made, have many active component like the nutrient substance of multiple beneficial skin such as alkaloid, saponin, flavonoid, quinones, organic acid, protein, vitamin, help skin heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, moisten effect such as whiten, nourshing Yin and drynsessmoistening prescription; When nourishing pack was applied to face, facial film and skin produced affinity, along with facial film is dry gradually; The skin temperature also raises in various degree, and the skin of face microcirculation is accelerated, and the skin pulling-over is strengthened; Excretory sebum of skin and moisture reverse osmosis are in horny layer; The skin softness is unfolded, and the pore instinct is opened a business, and the composition in the facial film infiltrates skin effectively; Played moisten, effects such as nutrition, reduce wrinkle and treatment, solve: skin problems such as black, yellow, dark yellow, chloasma, sunburn, cyasma, pox seal, cutis laxa, fine wrinkle comprehensively.
Give an example and non-limiting, when processing facial film, the operation of natural nutrition facial film is very simple; It is a kind of pulverous natural nutrition facial film, only need get an amount of facial film thing, add 80 degree left and right sides hot water transfer at 1: 1 be split into pasty state after; The Mel of adding some points again; Evenly be applied on the skin that needs nursing with small brushes then, cross 20-30 minute afterwash, coat cosmetic water (or equilibrium water, shrinkage water) and get final product.This nourishing pack physical therapy generally weekly 2-3 time or once a day is if be used as daily nursing, weekly or once got final product in three or four days.
Yam: Alias: potato gorgeous, the Department, etc., Rhizoma? Dioscoreae? Oppositae, Meridian: lung; spleen; kidney, Effects: Spleen; Yangfeihuoxue; Gushen; Yijing containing diosgenin (diosgenin), dopamine (dopamine ), hydrochloric acid, alkali yam and other ingredients.
Semen sojae atricolor: have another name called Semen Glycines, Semen Glycines, Soybean, Glycine max, nature and flavor: sweet; Flat, effect: invigorating spleen for diuresis; The alleviating distention in middle-JIAO intestinal stasis relieving; Removing toxic substances and promoting subsidence of swelling.
Brown sugar: have another name called brown sugar (Saccharum Sinensis Roxb.) etc., brown sugar, effect: liver is delayed in spleen reinforcing; Promoting blood circulation to remove blood stasis.
The Rhizoma Atractylodis Macrocephalae: be feverfew Rhizoma Atractylodis Macrocephalae rhizome, Rhizoma Atractylodis Macrocephalae, effect: invigorating the spleen and benefiting QI; The dampness diuretic; Hidroschesis; Antiabortive.
The Radix Paeoniae Alba: be the root of Paeoniaceae plant peony (cultivation article) and comospore Radix Paeoniae.Effect: nourish blood and seek; Relieving spasm to stop pain; The yin fluid astringing suppressing the hyperactive liver.
The Radix Angelicae Dahuricae: be the root of samphire Radix angelicae dahuricae and Qi Baizhi.Effect: expelling wind and removing dampness; Logical surreptitiously pain relieving; Detumescence and apocenosis.
Pseudobulbus Bletillae (Rhizoma Bletillae): be orchid Pseudobulbus Bletillae (Rhizoma Bletillae) rhizome.Rhizoma Bletillae, effect: astringing to arrest bleeding; Detumescence and promoting granulation.
Radix Panacis Quinquefolii: be the root of Araliaceae Radix Panacis Quinquefolii.Radix Panacis Quinquefolii, effect: boosting qi and nourishing yin; Relieve inflammation or internal heat and promote the production of body fluid.
Semen Coicis: be the kernel of grass Semen Coicis.Semen Coicis, effect: dampness removing spleen invigorating; Arthralgia relieving by relaxing muscles and tendons; Clearing away heat and discharging pus.
Semen Armeniacae Amarum: be the seed of rosaceous plant Fructus Pruni, wild apricot, Prunus armeniaca L.var.ansu Maxim., prunus mandshuricaKoehne.Effect: expelling phlegm for arresting cough; Relieving asthma; Intestine moistening; Following air to open numbness.
Poria: be the sclerotium of Polyporaceae fungus Poria.Poria, effect: eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.The white person of color is called Poria.
Radix Glycyrrhizae: be the root and rhizome of glycyrrhizic legume, Glycyrrhiza glabra L., Glycyrrhiza inflata Bat..Effect: QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.
Aloe: for the leaf juice of liliaceous plant Aloe vulgaris, stripe aloe vera, Aloe ferox Miller through spissated dry product.Aloes, effect: rush down down; Liver heat removing; Parasite killing.
Rhizoma Solani tuber osi: have another name called Rhizoma Solani tuber osi, be the tuber of plant of Solanaceae Rhizoma Solani tuber osi.RhiZoma Solani Tuberosi, effect: during stomach function regulating is strong; Removing toxic substances and promoting subsidence of swelling.
After above-mentioned natural product can directly be pulverized,, directly use as active skull cap components.Concrete as:
Get Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7 mealy potato 23-28
After the pulverizing,, pack into by every bag 15 gram and to seal in the bag, promptly get tens kinds of natural material medicine mixing and stirring.
After also can above-mentioned natural product can directly being pulverized, add the cosmetics adjuvant, be prepared into cosmetics and use, after Poria is directly pulverized, be formulated in the cosmetics; Directly join brown sugar in the cosmetics; It is medium that mealy potato is directly joined cosmetics.Concrete like (weight portion):
Get Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8 Radix Paeoniae Alba 5-9
Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7
After the pulverizing, add emulsifying agent, film former etc., process membrane.
Can also process the natural activity extract and use after the above-mentioned natural product extraction.Method for distilling does, above-mentioned natural product is put into solvent together or respectively, after dipping or the heating and refluxing extraction, filters, and obtains extract after concentrating.Extraction solvent of the present invention generally has no particular limits, the independent or mixing use of organic solvents such as alcohols such as particular methanol, ethanol, aqueous alcohols, acetone, ethyl acetate.Said extraction solvent also can be water.
Except that above-mentioned necessary composition; Be normally used for cosmetics and pharmaceuticals etc. the composition of skin preparations for extenal use; For example other whitening agent, wetting agent, antioxidant, oiliness composition, UV absorbent, surfactant, thickening agent, alcohols, powder composition, pigment, water composition, water, various skin-nourishing agent etc. can suitably be added as required.
Also can proper fit using of other; For example: the metal chelating agent of disodium edetate, edetate trisodium, sodium citrate, sodium hexametaphosphate, Polymeric sodium metaphosphate., gluconic acid etc., the saccharide of the whitening agent of other of the medicine of the hot water extract of caffeine, tannic acid, verapamil, tranamic acid and its derivant, sea buckthorn fruit, various crude drug, acetic acid VE, glycyrrhizic acid and its derivant or its salt etc., vitamin C, magnesium ascorbyl phosphate, ascorbic acid glucoside, arbutin, kojic acid etc., glucose, fructose, mannose, sucrose, trehalose etc. etc.
So-called cosmetics of the present invention, for example ointment, cream, emulsion, washing liquid, beauty treatment paste, baths etc. are that originally to be used to the material of skin preparations for extenal use whichever all passable, dosage form does not receive special restriction.
The specific embodiment
Through embodiment the present invention is described in further detail below.But the present invention has more than and is defined in these examples.Proportional quantity is ratio of weight and number if no special instructions.
Embodiment 1, the preparation of facial film
Rhizoma Dioscoreae 5 Rhizoma Atractylodis Macrocephalaes 8 Radix Paeoniae Albas 9
The Radix Angelicae Dahuricae 5 Pseudobulbus Bletillae (Rhizoma Bletillae) 4 Radix Panacis Quinquefoliis 20
Semen Coicis 30 Semen Armeniacae Amarums 8 Poria 7
Aloe 4
The above-mentioned raw materials medicine adds 10 times of amounts of entry, extracts twice, and each 1 hour, extracting solution merged concentrate drying, obtains the natural activity extract.Add the conventional adjuvant of facial film, process facial film.
Embodiment 2, the preparation of facial film and use
Get Semen Glycines 2.2g-2.8g Rhizoma Dioscoreae 0.5g-1g brown sugar 1.2g-2g Rhizoma Atractylodis Macrocephalae 0.3g-0.8g Radix Paeoniae Alba 0.5g-0.9g Radix Angelicae Dahuricae 0.5g-0.8g Pseudobulbus Bletillae (Rhizoma Bletillae) 0.4g-0.6g Radix Panacis Quinquefolii 2g-2.5g SEMEN COICIS 2g-3g Semen Armeniacae Amarum 0.5g-0.8g Poria 0.5g-0.7g Radix Glycyrrhizae 0.3g-0.6g Aloe 0.4g-0.7g mealy potato 2.3g-2.8g
After directly pulverizing,, pack into by every bag 15 gram and to seal in the bag tens kinds of natural material mixing and stirring.During use with add 80 degree left and right sides hot water 1: 1 transfer be split into pasty state after, the Mel of adding some points again evenly is applied on the skin that needs nursing with small brushes then, crosses 20-30 minute afterwash, coats cosmetic water (or equilibrium water, shrinkage water) and gets final product.
Embodiment 3, the preparation of active skull cap components
Rhizoma Dioscoreae 10 Rhizoma Atractylodis Macrocephalaes 8 Radix Paeoniae Albas 9
The Radix Angelicae Dahuricae 8 Pseudobulbus Bletillae (Rhizoma Bletillae) 6 Radix Panacis Quinquefoliis 25
Semen Coicis 30 Semen Armeniacae Amarums 8 Porias 7
Aloe 7
The above-mentioned raw materials medicine adds 8 times of amounts of ethanol, extracts 1 time, extracts 1 hour, and extracting solution merges concentrate drying, obtains the natural activity extract.
Embodiment 4, the preparation of active skull cap components
Semen sojae atricolor 22 Rhizoma Dioscoreaes 5 Rhizoma Atractylodis Macrocephalaes 3 Radix Paeoniae Albas 5
The Radix Angelicae Dahuricae 5 Pseudobulbus Bletillae (Rhizoma Bletillae) 4 Radix Panacis Quinquefoliis 20
Semen Coicis 20 Semen Armeniacae Amarums 5 Poria 5
Aloe 4
The above-mentioned raw materials medicine adds 8 times of amounts of methanol, extracts 1 time, extracts 1 hour, and extracting solution merges concentrate drying, obtains the natural activity extract.
Embodiment 5, the preparation of active skull cap components
Brown sugar 16 Rhizoma Dioscoreaes 7 Rhizoma Atractylodis Macrocephalaes 5 Radix Paeoniae Albas 7
The Radix Angelicae Dahuricae 6 Pseudobulbus Bletillae (Rhizoma Bletillae) 5 Radix Panacis Quinquefoliis 22
Semen Coicis 25 Semen Armeniacae Amarums 6 Poria 6
Aloe 6
The above-mentioned raw materials medicine adds 8 times of amounts of ethyl acetate, extracts 1 time, extracts 1 hour, and extracting solution merges concentrate drying, obtains the natural activity extract.
Embodiment 6, the preparation of active skull cap components
Radix Glycyrrhizae 4 Rhizoma Dioscoreaes 7 Rhizoma Atractylodis Macrocephalaes 5 Radix Paeoniae Albas 6
The Radix Angelicae Dahuricae 7 Pseudobulbus Bletillae (Rhizoma Bletillae) 5 Radix Panacis Quinquefoliis 23
Semen Coicis 25 Semen Armeniacae Amarums 6 Poria 6
Aloe 5
The above-mentioned raw materials medicine adds 8 times of amounts of 50% ethanol, extracts 1 time, extracts 1 hour, and extracting solution merges concentrate drying, obtains the natural activity extract.
Embodiment 7, the preparation of active skull cap components
Mealy potato 25 Rhizoma Dioscoreaes 7 Rhizoma Atractylodis Macrocephalaes 7 Radix Paeoniae Albas 6
The Radix Angelicae Dahuricae 5 Pseudobulbus Bletillae (Rhizoma Bletillae) 5 Radix Panacis Quinquefoliis 24
Semen Coicis 28 Semen Armeniacae Amarums 7 Poria 6
Aloe 6
The above-mentioned raw materials medicine adds 15 times of amounts of 50% methanol, extracts 1 time, extracts 1 hour, and extracting solution merge to reclaim methanol and concentrates, add the entry suspendible after, last D101 macroporous resin 75% ethanol elution, concentrate drying obtains the natural activity extract.
Embodiment 8, the preparation of active skull cap components
Semen Glycines 25 Rhizoma Dioscoreaes 7 brown sugar 15 Rhizoma Atractylodis Macrocephalaes 5
The Radix Paeoniae Alba 7 Radixs Angelicae Dahuricae 7 Pseudobulbus Bletillae (Rhizoma Bletillae) 5 Radix Panacis Quinquefoliis 23
Semen Coicis 25 Semen Armeniacae Amarums 6 Porias 6 Radix Glycyrrhizaes 4
Aloe 5 mealy potatos 25
The above-mentioned raw materials medicine adds 15 times of amounts of 25% ethanol, extracts 1 time, extracts 1 hour, and extracting solution merges recovery ethanol and concentrates, and drying obtains the natural activity extract.
Embodiment 9, the preparation of active skull cap components
Rhizoma Dioscoreae 10 brown sugar 20 Rhizoma Atractylodis Macrocephalaes 8
The Radix Paeoniae Alba 9 Radixs Angelicae Dahuricae 8 Pseudobulbus Bletillae (Rhizoma Bletillae) 6 Radix Panacis Quinquefoliis 20
Semen Coicis 20 Semen Armeniacae Amarums 5 Porias 6
Aloe 5 mealy potatos 23
The above-mentioned raw materials medicine adds 15 times of amounts of 75% acetone, extracts 1 time, extracts 1 hour, and extracting solution merge to reclaim acetone and concentrates, add the entry suspendible after, last D101 macroporous resin 50% ethanol elution, concentrate drying obtains the natural activity extract.
Embodiment 10, the beauty treatment paste
(prescription) weight %
(A phase)
Dipropylene glycol 5.0
Polyoxy ethane (60 moles) hardened castor oil 5.0
(B phase)
(C phase)
Ascorbic acid 2-glucoside 2.0
Polyvinyl alcohol (basicity 90, the degree of polymerization 2000) 13.0
Ethanol 7.0
Purified Water adds to 100%
(method for making)
A phase, B phase, C are dissolved into the homogeneous state mutually respectively, B is added to A phase solubilize mutually.Then this liquid being added C fills mutually afterwards.
Safety experiment
Get various cosmetics of embodiment 1-10 or active skull cap components, be applied in 100 experimenter's faces, smear 2 hours time, smeared continuously 30 days, the result has no untoward reaction.Prove that said active skull cap components is as safe as a house.
The technique effect experiment
1, anti aging effect
Use the active skull cap components of embodiment 3-9, be divided into 7 groups, 30 volunteers of every group of collection remove the canthus wrinkle experiment.Right eye uses the said goods, once a day, smears 20 minutes time at every turn, and left eye need not.
First group was used 1 month, and 80% is effective, and 20% is invalid;
Second group was used 1 month, and 90% is effective, and 10% is invalid;
The 3rd group was used 1 month, 70% produce effects, and 60% is effective, and 10% is invalid;
The 4th group was used 1 month, 40% produce effects, and 50% is effective, and 10% is invalid;
The 5th group was used 1 month, 50% produce effects, and 40% is effective, and 10% is invalid;
The 6th group was used 1 month, 50% produce effects, and 40% is effective, and 10% is invalid;
The 7th group was used 1 month, 50% produce effects, and 40% is effective, and 10% is invalid.
In this experimental example, criterion of therapeutical effect: wrinkle disappears, and is produce effects; Wrinkle shoals, for effectively; Wrinkle does not have improvement, for invalid.The experimenter is reflected behind these article of use mostly has comfort, and skin smooth is fine and smooth, and moisture-keeping function is obvious.
2, efficient sun-proof result experiment
Will by with 40 of the experimenters' of artificial light (UV-A+UV-B) irradiation 30 minutes (shine 3 days 10 minutes every days) upper arm inside line skin as subjects, from letting behind 5 days of day of solar radiation, each test sample respectively was coated with for 4 weeks 1 time sooner or later.Every group 8 people of experimenter is divided into 5 groups, and the prescription that is used in following expression makes an experiment.
(pure phase)
95% ethanol, 55.0 weight %
Polyoxy ethane (25 moles) hardened castor oil ether 2.0
The antioxidant antiseptic is an amount of
Essence is an amount of
Active skull cap components (table 1 record)
(water)
Glycerol 5.0
Sodium hexameta phosphate is an amount of
Deionized water adds to 100%
< method for making >
Prepare water, pure phase respectively, then both are mixed the molten one that is.
[evaluation methodology]
According to following criterion, judge the light color effect after using.
< criterion >
◎: occur produce effects and effective ratio among the experimenter and be 80% when above
Zero: when occurring produce effects and effective ratio among the experimenter and being 50%～less than 80%
△: when occurring produce effects and effective ratio among the experimenter and being 30%～less than 50%
*: when occurring produce effects and effective ratio among the experimenter and being less than 30%
The test sample that preparation is made up of the prescription of above-mentioned test method(s) record, the medicament of putting down in writing with table 1 compares whitening effect.The result sees table 1.
Table 1
Can find out clearly that by table 1 effect after letting solar irradiation shine has been added the test sample of the embodiment of the invention, can prevent superfluous melanic calmness, the blackening of the prevention colour of skin.And along with the increase of use amount, effect is strengthening.
3, whitening effect experiment
Use derives from the B16 melanoma cultured cell of mice.In CO2 incubator (95% air, 5% carbon dioxide), in containing Eagle ' the s MEM culture medium of 10%FBS and theophylline (0.09mg/ml), under 37 ℃ condition, cultivate.Cultivate and add sample solution after 24 hours, final concentration (extracting dry thing conversion concentration) is adjusted into 2 * 10-3～10-5 weight %, continue again to cultivate 3 days, judge the melanin growing amount according to following method vision.
The vision of melanin amount is judged
Cover the placement diffuser plate at plate,, compare with the occasion of the sample (benchmark) that does not add active skull cap components (adding concentration is 0.01% weight) with handstand microscope observing cell number and intracellular melanin amount.This result is as shown in table 2.In addition, example is as a reference used knownly to have melanin and generate inhibiting arbutin, carries out above-mentioned same experiment.This result also is presented in the table 2 in the lump.About the propagation of cell, the result of all samples that use in the experiment is " unrestraint ".
Determinating reference
Zero: than reference white (melanin amount)
△: than benchmark white slightly (melanin amount)
*: be same as benchmark (melanin amount)
Table 2
| Active skull cap components | Effect |
| Arbutin | △ |
| Pseudobulbus Bletillae (Rhizoma Bletillae) (methanol extraction | × |
| The Rhizoma Atractylodis Macrocephalae (methanol extraction) | △ |
| Poria (methanol extraction | × |
| Embodiment 3 | ○ |
| Embodiment 4 | ○ |
| Embodiment 5 | ○ |
| Embodiment 6 | ○ |
| Embodiment 7 | ○ |
| Embodiment 8 | ○ |
| Embodiment 9 | ○ |
4, defying age experiment
1, material
A, this tests used Kunming mouse (body weight 25-30g) Aged Mice (20-21 is of the same age) and provides by the Suzhou Medical College animal center.
The active skull cap components of b, active skull cap components: embodiment 8; Add 15 times of amounts of 25% ethanol with Semen Glycines, Rhizoma Dioscoreae, brown sugar, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Panacis Quinquefolii, Semen Coicis, Semen Armeniacae Amarum, Poria, Radix Glycyrrhizae, Aloe, mealy potato; Extract 1 time, extracted 1 hour, extracting solution merges recovery ethanol and concentrates; Drying, the unit's of obtaining medicine natural activity extract.
C, hydrocarbon proline standard substance, the BDH Company products.
D, thiobarbituricacid (TBA), tetraethoxypropane (TEP) is the AR level, available from chemical reagent shop, Shanghai.721 spectrophotometers, Shanghai the 3rd analytical tool factory.
2, method
Get 30 of Aged Mice, be divided into 16 groups at random, 10 every group, irritate clothes active skull cap components 30ml/kg respectively, normal saline 0.5ml/ only under the equal conditions, fed continuous 30 days, gave eye socket blood sampling in 2 hours behind the active skull cap components of the present invention, was used to measure SOD.
Active skull cap components can improve SOD vigor in the Aged Mice erythrocyte; Reduce LPO content in the serum simultaneously, compare, evident difference is all arranged with the normal saline group; And the active skull cap components after the combination obviously is superior to the single medicinal material active skull cap components, has cooperative effect.Result such as following table 3:
Table 3
| Group | SOD(u/ghb) |
| Normal saline | 1340±358 |
| Embodiment 8 | 2246±480** |
| Semen Glycines | 1701±352 |
| Rhizoma Dioscoreae | 1523±247 |
| Brown sugar | 1392±286 |
| The Rhizoma Atractylodis Macrocephalae | 1699±374 |
| The Radix Paeoniae Alba | 1640±380 |
| The Radix Angelicae Dahuricae | 1725±291 |
| Pseudobulbus Bletillae (Rhizoma Bletillae) | 1682±391 |
| Radix Panacis Quinquefolii | 1892±221 |
[0259]
| Semen Coicis | 1529 ± 314 |
| Semen Armeniacae Amarum | 1567 ± 428 |
| Poria | 1894 ± 354 |
| Radix Glycyrrhizae | 1692 ± 309 |
| Aloe | 1852 ± 375 |
| Mealy potato | 1457 ± 320 |
Annotate: with normal saline group ratio, * * P＜0.001.
Claims (9)
1. natural activity cosmetics is characterized in that wherein active skull cap components is prepared by following materials of weight proportions:
Rhizoma Dioscoreae 5-10 Rhizoma Atractylodis Macrocephalae 3-8 Radix Paeoniae Alba 5-9
Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7
Aloe 4-7.
2. natural activity cosmetics as claimed in claim 1 is characterized in that can also containing in the said raw material in Semen sojae atricolor, brown sugar, Radix Glycyrrhizae, the mealy potato one or more, and weight proportion is:
Semen sojae atricolor 22-28 brown sugar 12-20 Radix Glycyrrhizae 3-6 mealy potato 23-28.
3. natural activity cosmetics as claimed in claim 2 is characterized in that said Semen sojae atricolor is a Semen Glycines, and said Poria is a Poria.
4. natural activity cosmetics as claimed in claim 2 is characterized in that wherein active skull cap components is prepared by following materials of weight proportions:
Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7 mealy potato 23-2.8
5. natural activity cosmetics as claimed in claim 2 is characterized in that wherein active skull cap components is prepared by following materials of weight proportions:
Semen Glycines 22-28 Rhizoma Dioscoreae 5-10 brown sugar 12-20 Rhizoma Atractylodis Macrocephalae 3-8
Radix Paeoniae Alba 5-9 Radix Angelicae Dahuricae 5-8 Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 Radix Panacis Quinquefolii 20-25
Semen Coicis 20-30 Semen Armeniacae Amarum 5-8 Poria 5-7 Radix Glycyrrhizae 3-6
Aloe 4-7 mealy potato 23-28.
6. natural activity cosmetics as claimed in claim 5 is characterized in that active skull cap components is wherein obtained by the feedstock production of following weight:
Semen Glycines 2.2g-2.8g Rhizoma Dioscoreae 0.5g-1g brown sugar 1.2g-2g Rhizoma Atractylodis Macrocephalae 0.3g-0.8g Radix Paeoniae Alba 0.5g-0.9g Radix Angelicae Dahuricae 0.5g-0.8g Pseudobulbus Bletillae (Rhizoma Bletillae) 0.4g-0.6g Radix Panacis Quinquefolii 2g-2.5g SEMEN COICIS 2g-3g Semen Armeniacae Amarum 0.5g-0.8g Poria 0.5g-0.7g Radix Glycyrrhizae 0.3g-0.6g Aloe 0.4g-0.7g mealy potato 2.3g-2.8g pulverizes mixing and stirring with tens kinds of natural materials.
7. the described natural activity cosmetics of claim 5 is characterized in that said Radix Panacis Quinquefolii is with Radix Ginseng, Korean Ginseng or Radix Pseudostellariae replacement.
8. the purposes of the described natural activity cosmetics of claim 1-6 in the cosmetic composition of preparation Pear Power and/or anti aging effect effect.
9. purposes as claimed in claim 7, wherein said cosmetic composition are used for prevention and improve pigmentation, cutis laxa, fine wrinkle.
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Application publication date: 20120222 |