CN102353572A - Preparation method of standard material for detecting ferulic acid in cosmetics - Google Patents
Preparation method of standard material for detecting ferulic acid in cosmetics Download PDFInfo
- Publication number
- CN102353572A CN102353572A CN2011101800710A CN201110180071A CN102353572A CN 102353572 A CN102353572 A CN 102353572A CN 2011101800710 A CN2011101800710 A CN 2011101800710A CN 201110180071 A CN201110180071 A CN 201110180071A CN 102353572 A CN102353572 A CN 102353572A
- Authority
- CN
- China
- Prior art keywords
- forulic acid
- cosmetics
- phase
- detecting
- standard substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to a preparation method of a standard material for detecting ferulic acid in cosmetics. The method comprises the following step of mixing propylene glycol solution of the ferulic acid and cosmetic emulsion to form the standard material for detecting the ferulic acid in the cosmetics, wherein the cosmetic emulsion comprises the following components in percentage by weight: 72 to 78 percent of deionized water, 3 to 3.5 percent of propylene glycol and 0.45 to 0.5 percent of xanthan gum in an A phase, 4 to 4.5 percent of stearic acid, 2 to 4 percent of cetearyl alcohol and 10 to 14 percent of No.26 white oil in a B phase, and 1.25 to 1.3 percent of phenoxyethanol and ethylhexyl glycerol in a C phase; and the content of the ferulic acid in the standard material is 0.5 to 2.5 percent. The invention has the advantages that: the ferulic acid is mixed with the cosmetic emulsion to form the standard material for detecting the ferulic acid in the cosmetics, and the standard material is the same as a cosmetic sample containing the ferulic acid during actual use, so that the ferulic acid in the cosmetics better meets the requirements of actual application after detection, and is more accurately detected.
Description
Technical field
The present invention relates to the cosmetics detection range, relate in particular to a kind of compound method that is used for detecting the standard substance of cosmetics forulic acid.
Background technology
The chemical name of forulic acid (Ferulic Acid) is 4 hydroxyls, 3 methoxy cinnamic acids, is one of derivant of cinnamic acid (claiming cinnamic acid again, 3 phenyl, 2 acrylic acid, molecular structure).The forulic acid detection is one of big event that Chinese herbal medicine effective ingredients detects in the cosmetics in the cosmetics; The direct compound test method of present more employing; But; In practical application; Forulic acid in the cosmetics is with after formula components is mixed; Have than big difference with compound test when detecting again Yu directly, can influence the degree of accuracy of detection.Compare with n-compound; The cosmetic standard material not only has the measurement standard of accurate value; Also have one or more enough all even characteristic values of well having confirmed; Traceability with value is to the detection level, the unified measured value that improve Cosmetic Manufacture, cosmetics check, to estimate and carry out personnel checking-up and management work standardization etc. for the cosmetics method of inspection of setting up all significant.
Summary of the invention
Technical matters to be solved by this invention is to provide a kind of compound method that is used for detecting the standard substance of cosmetics forulic acid; Forulic acid is mixed with cosmetic emulsion through certain technical method, be formed for detecting the standard substance that forulic acid detects in the cosmetics.
The present invention solves the problems of the technologies described above the technical scheme of being taked: a kind of compound method that is used for detecting the standard substance of cosmetics forulic acid; The propylene glycol solution of forulic acid is mixed with cosmetic emulsion; Be formed for detecting the standard substance of forulic acid in the cosmetics, wherein
The prescription of said cosmetic emulsion is by weight percentage:
A phase deionized water 72～78
Propylene glycol 3～3.5
Xanthan gum 0.45～0.5;
B phase stearate 4～4.5
16 alcohol 2～4
26# white oil 10～14;
C phase Phenoxyethanol and ethylhexyl glycerine 1.25～1.3;
The concentration of said forulic acid in standard substance reaches 0.5～2.5%.
The present invention through with the ferulyolated compound with after the cosmetic formulations composition mixes; The identical cosmetic sample that contains forulic acid when processing with actual the use; Thereby make the detection of forulic acid in the cosmetics is more met the state of practical application, and make detection more accurate.
Concrete, A mutually in, the content of deionized water can be 72,73,74,75,76,77 or 78%; The content of propylene glycol can be 3,3.1,3.2,3.3,3.4 or 3.5%; Xanthan gum 0.45,0.46,0.47,0.48,0.49 or 0.5%;
B mutually in, the content of stearate can be 4,4.1,4.2,4.3,4.4 or 4.5%; The content of 16 alcohol can be 2,2.5,3,3.5 or 4%; The content of 26# white oil can be 10,11,12,13 or 14%;
The content of the Phenoxyethanol of C phase and ethylhexyl glycerine can be 1.25,1.26,1.27,1.28,1.29 or 1.3%.
On the basis of such scheme, the compound method of cosmetic emulsion comprises the steps:
The first step: in advance the xanthan gum of A in mutually is uniformly dispersed in glycerine;
Second step: all the other components of A phase are added, be heated to more than 80 ℃, stir; With B each component mixing mutually, be heated to more than 80 ℃, stir;
The 3rd step: stir down, B is added to the A phase, homogeneous is more than 3 minutes;
The 4th step: stir down, be cooled to below 45 ℃, add the C phase, stir;
The 5th step: stir down, be cooled to room temperature, process cosmetic emulsion.
On the basis of such scheme; The propylene glycol solution concentration of said forulic acid is 2～3 g/100mL; Slowly join the propylene glycol solution of forulic acid in the cosmetic emulsion; And make the ultimate density of forulic acid in standard substance reach 0.5～2.5%, keep temperature constant under 15～25 ℃ of conditions with minimum water evaporates, slowly to stir.
Concrete, the propylene glycol solution concentration of forulic acid can be 2,2.2,2.4,2.6,2.8 or 3 g/100mL, the ultimate density of forulic acid in standard substance can be 0.5,0.8,1.0,1.2,1.5,1.8,2.0,2.2 or 2.5%.
The invention has the beneficial effects as follows:
The present invention mixes forulic acid with cosmetic emulsion; Be formed for detecting the standard substance of forulic acid in the cosmetics; This standard substance contains forulic acid when using with reality cosmetic sample is identical; Thereby make the detection of forulic acid in the cosmetics is more met the state of practical application, and make detection more accurate.
Embodiment
A kind of compound method that is used for detecting the standard substance of cosmetics forulic acid is mixed the propylene glycol solution of forulic acid with cosmetic emulsion, be formed for detecting the standard substance of forulic acid in the cosmetics, wherein,
The prescription of said cosmetic emulsion is by weight percentage:
The compound method of cosmetic emulsion comprises the steps:
The first step: in advance the xanthan gum of A in mutually is uniformly dispersed in glycerine;
Second step: all the other components of A phase are added, be heated to more than 80 ℃, stir; With B each component mixing mutually, be heated to more than 80 ℃, stir;
The 3rd step: stir down, B is added to the A phase, homogeneous is more than 3 minutes;
The 4th step: stir down, be cooled to below 45 ℃, add the C phase, stir;
The 5th step: stir down, be cooled to room temperature, process cosmetic emulsion.
Embodiment 1
Be mixed with cosmetic emulsion according to prescription and preparation technology in the table.Forulic acid is mixed with the 2.5g/100mL propylene glycol solution, and the propylene glycol solution that will contain forulic acid then slowly joins in the emulsion, makes the ultimate density of forulic acid reach 0.5%, under the condition that keeps temperature constant and minimum water evaporates, slowly stirs packing.
Embodiment 2
Be mixed with cosmetic emulsion according to prescription and preparation technology in the table.Forulic acid is mixed with the 2.5g/100mL propylene glycol solution, and the propylene glycol solution that will contain forulic acid then slowly joins in the emulsion, makes the ultimate density of forulic acid reach 2.0%, under the condition that keeps temperature constant and minimum water evaporates, slowly stirs packing.
Embodiment 3
Be mixed with cosmetic emulsion according to prescription and preparation technology in the table.Forulic acid is mixed with the 2.5g/100mL propylene glycol solution, and the propylene glycol solution that will contain forulic acid then slowly joins in the emulsion, makes the ultimate density of forulic acid reach 2.5%, under the condition that keeps temperature constant and minimum water evaporates, slowly stirs packing.
The purity of employed forulic acid is more than 98%.
Standard substance of the present invention is used for detecting the uniformity testing of cosmetics forulic acid:
Homogeneity is the most basic attribute of standard substance; Project (GB/T15000.9-94) is randomly drawed the n bottle to the standard substance of being developed according to " standard model work guide rule (5): chemical constitution standard model technology general rule "; With wherein one bottle as basic contrast points; All the other n-1 bottles adopt corresponding mathematical statistics method that the homogeneity of standard substance is studied as check point.。
1.1 uniformity testing method
With F method of inspection and t method of inspection.
Specific practice is: in 16 bottles of samples that extract, optional one bottle of basic contrast points of conduct is done the measurement of one group of 15 ferulaic acid content altogether; All the other 15 bottles as the checkpoint, every bottle of measurement of making a ferulaic acid content; Difference calculating mean value and variance.
Significant difference with F method of inspection check this variance of taking a sample has following judgment formula:
In the formula:
S
1 2The variance of-checkpoint
S
2 2The variance of-contrast points
F α (ν
1, ν
2)-given level of significance α and degree of freedom (ν
1, ν
2) the critical value of statistical test, F α (14,14)=2.48 tables look-up;
ν-degree of freedom, ν=n-1.
When satisfying formula (1), then there is not significant difference in two groups variance.
The significant difference of t method of inspection check this mean value of taking a sample has following judgment formula:
In the formula:
x
1The average value measured of-checkpoint;
x
2The average value measured of-contrast points;
-given level of significance, total degree of freedom (n
1+ n
2-2) critical value, the t that tables look-up (0.05,28)=2.05.
When satisfying formula (2), there is not significant difference in two groups mean value.
1.2 sampling number
The total number of samples of each species N is 200 bottles, according to 3
to calculate the number of samples, randomly selected 18 bottles, which take 16 bottles for homogeneity testing.
1.3 sample mode
Press table of random numbers sample drawn, remove repetition and useless, extract 16 bottles of samples.
1.4 check instrument
High performance liquid chromatograph, model: Agilent 1100.
If there is not significant difference in the assay of F method of inspection and t method of inspection, illustrate that then this standard substance is uniform.
Data by table 1 and table 2 can know, in level of significance α=0.05, the degree of freedom of inspection group and contrast groups is (F under 14 the situation
0.05(14,14)=2.48, t
(0.05,28)=2.05), the mensuration result of two kinds of contents levels all meets formula (1) and formula (2).Therefore can judge two groups of results' mensuration variance indifference, measure the mean value indifference.
Claims (3)
1. compound method that is used for detecting the standard substance of cosmetics forulic acid is characterized in that: the propylene glycol solution of forulic acid mixed with cosmetic emulsion, is formed for detecting the standard substance of forulic acid in the cosmetics, wherein,
The prescription of said cosmetic emulsion is by weight percentage:
A phase deionized water 72～78
Propylene glycol 3～3.5
Xanthan gum 0.45～0.5;
B phase stearate 4～4.5
16 alcohol 2～4
26# white oil 10～14;
C phase Phenoxyethanol and ethylhexyl glycerine 1.25～1.3;
The concentration of said forulic acid in standard substance reaches 0.5～2.5%.
2. the compound method that is used for detecting the standard substance of cosmetics forulic acid according to claim 1, it is characterized in that: the compound method of cosmetic emulsion comprises the steps:
The first step: in advance the xanthan gum of A in mutually is uniformly dispersed in glycerine;
Second step: all the other components of A phase are added, be heated to more than 80 ℃, stir; With B each component mixing mutually, be heated to more than 80 ℃, stir;
The 3rd step: stir down, B is added to the A phase, homogeneous is more than 3 minutes;
The 4th step: stir down, be cooled to below 45 ℃, add the C phase, stir;
The 5th step: stir down, be cooled to room temperature, process cosmetic emulsion.
3. the compound method that is used for detecting the standard substance of cosmetics forulic acid according to claim 1; It is characterized in that: the propylene glycol solution concentration of said forulic acid is 2～3 g/100mL; Slowly join the propylene glycol solution of forulic acid in the cosmetic emulsion; And make the ultimate density of forulic acid in standard substance reach 0.5～2.5%, keep temperature constant under 15～25 ℃ of conditions with minimum water evaporates, slowly to stir.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101800710A CN102353572A (en) | 2011-06-30 | 2011-06-30 | Preparation method of standard material for detecting ferulic acid in cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101800710A CN102353572A (en) | 2011-06-30 | 2011-06-30 | Preparation method of standard material for detecting ferulic acid in cosmetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102353572A true CN102353572A (en) | 2012-02-15 |
Family
ID=45577179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101800710A Pending CN102353572A (en) | 2011-06-30 | 2011-06-30 | Preparation method of standard material for detecting ferulic acid in cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102353572A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106908576A (en) * | 2017-01-19 | 2017-06-30 | 北京轻研究院 | Emulsus class cosmetic standard material containing heavy metal cadmium and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1261269A (en) * | 1997-06-27 | 2000-07-26 | 尤尼利弗公司 | Improved cosmetic composition containing ferulic acid esters |
| CN101862272A (en) * | 2010-07-09 | 2010-10-20 | 北京昂立达技术有限责任公司 | Application of ferulic acid derivative in cosmetics and preparation method thereof |
| CN101904806A (en) * | 2010-09-03 | 2010-12-08 | 上海市计量测试技术研究院 | Method for preparing standard substance for detecting antibiotics in cosmetics |
| CN101912351A (en) * | 2010-09-03 | 2010-12-15 | 上海相宜本草化妆品有限公司 | Method for preparing standard substance for detecting heavy metal in cosmetics |
| CN101936835A (en) * | 2010-09-03 | 2011-01-05 | 上海相宜本草化妆品有限公司 | Method for preparing standard substance for detecting scurf removing agent in cosmetics |
-
2011
- 2011-06-30 CN CN2011101800710A patent/CN102353572A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1261269A (en) * | 1997-06-27 | 2000-07-26 | 尤尼利弗公司 | Improved cosmetic composition containing ferulic acid esters |
| CN101862272A (en) * | 2010-07-09 | 2010-10-20 | 北京昂立达技术有限责任公司 | Application of ferulic acid derivative in cosmetics and preparation method thereof |
| CN101904806A (en) * | 2010-09-03 | 2010-12-08 | 上海市计量测试技术研究院 | Method for preparing standard substance for detecting antibiotics in cosmetics |
| CN101912351A (en) * | 2010-09-03 | 2010-12-15 | 上海相宜本草化妆品有限公司 | Method for preparing standard substance for detecting heavy metal in cosmetics |
| CN101936835A (en) * | 2010-09-03 | 2011-01-05 | 上海相宜本草化妆品有限公司 | Method for preparing standard substance for detecting scurf removing agent in cosmetics |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106908576A (en) * | 2017-01-19 | 2017-06-30 | 北京轻研究院 | Emulsus class cosmetic standard material containing heavy metal cadmium and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101936835B (en) | Method for preparing standard substance for detecting scurf removing agent in cosmetics | |
| CN101904806B (en) | Method for preparing standard substance for detecting antibiotics in cosmetics | |
| Scholte | Determination of thermodynamic parameters of polymer–solvent systems from sedimentation–diffusion equilibrium in the ultracentrifuge | |
| CN101912351B (en) | Method for preparing standard substance for detecting heavy metal in cosmetics | |
| CN101904803B (en) | Method for preparing standard substance for detecting preservative in cosmetic | |
| CN106153498A (en) | A kind of new method detecting solute concentration in solution and device thereof | |
| CN102944654A (en) | Preparation method of standard substance for detecting arecoline in cosmetic | |
| CN102680640A (en) | Method for conveniently and rapidly determining total nitrogen content in organic material | |
| CN103951840B (en) | A kind of preparation method and application for detecting salicylic fluorescence sense film | |
| CN103293175B (en) | Measure the method for liquid soluble glass chemical composition | |
| CN102346104A (en) | Preparation method of standard substance used for detecting aconitine in cosmetic | |
| CN102313735A (en) | Kit for rapidly detecting pH value of water for fishery culture and detection method thereof | |
| CN102072900B (en) | Acid value measurement method for high-viscosity lubricating oil | |
| CN104458739A (en) | Method for detecting acid value of vegetable oil containing oryzanol | |
| CN103868916A (en) | Biological test method for rapidly detecting comprehensive toxicity of traditional Chinese medicine | |
| CN102353572A (en) | Preparation method of standard material for detecting ferulic acid in cosmetics | |
| CN102944652A (en) | Preparation method of standard substance for detecting aristolochic acid A in cosmetic | |
| CN104075988A (en) | Method for testing dispersity of wet chopped strands of glass fibers in water | |
| CN102706708A (en) | Calibration test cube manufacturing method for x-ray residual stress testing system | |
| CN104359900A (en) | Kit for quickly detecting content of proline in honey | |
| CN103940706B (en) | Definite method of petroleum crude oil three-component compound system | |
| CN103969157B (en) | A kind of method measuring colloidal electrolyte gelation time | |
| Melzer et al. | Measurement of diffusivity, viscosity, density and refractivity of eight binary liquid mixtures | |
| CN102319186A (en) | Method for preparing standard substance for detecting ginsenoside rg1 in cosmetics | |
| CN106198517A (en) | Formaldehyde testing reagent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120215 |