CN102350292A - Reaction kettle for preparing dihydroartemisinin - Google Patents
Reaction kettle for preparing dihydroartemisinin Download PDFInfo
- Publication number
- CN102350292A CN102350292A CN2011102578900A CN201110257890A CN102350292A CN 102350292 A CN102350292 A CN 102350292A CN 2011102578900 A CN2011102578900 A CN 2011102578900A CN 201110257890 A CN201110257890 A CN 201110257890A CN 102350292 A CN102350292 A CN 102350292A
- Authority
- CN
- China
- Prior art keywords
- kettle
- condensed fluid
- dihydroartemisinine
- condenser coil
- kettle body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention relates to a reaction kettle for preparing dihydroartemisinin. The reaction kettle comprises a kettle frame as well as a kettle body and an agitation device which are erected on the kettle frame, wherein the kettle body comprises a kettle part and a kettle cover which is connected with the kettle part in a sealing way, a discharging hole is arranged in the lower part of the kettle body and a feeding hole is arranged in the kettle cover; jackets of a water inlet and a water outlet are arranged on the periphery of the kettle part; the reaction kettle further comprises a condensing coil which is arranged inside the kettle body; and the condensing coil is provided with a condensed fluid inlet and a condensed fluid outlet which stretch out of the kettle body. According to the reaction kettle provided by the invention, not only the jackets allowing the condensed fluid to flow through are arranged outside the kettle body, but also the condensing coil is arranged inside the kettle body, so that when the condensed water or other condensed fluids are introduced to the condensing coil, heat exchange can be directly generated between the condensed fluid and materials in the kettle body, and then the materials in the kettle body are rapidly cooled. Therefore, the reaction kettle provided by the invention is high in temperature reduction speed, is good in safety when the reaction kettle is used for preparing the dihydroartemisinin, and can be used for effectively avoiding degrading the dihydroartemisinin.
Description
Technical field
the present invention relates to a kind of agitated reactor, particularly a kind of preparation dihydroartemisinine agitated reactor.
Background technology
dihydroartemisinine is the reduzate of qinghaosu, can be used for the symptom control of various types of malaria, and especially resisting the pernicious and pernicious malaria of chloroquine has better curative effect, and it is in similar medicine, and drug effect is the strongest, and is also the safest.One of important channel of synthetic dihydroartemisinine is to be prepared by qinghaosu anti-hydroboration reduction reaction of giving birth in sodium borohydride/methanol system.Known, the hydroboration reduction reaction is an exothermic reaction, and exothermic heat of reaction is big, and therefore, when reaction, that temperature of reaction system must be controlled is lower, otherwise, the degraded that is easy to bring potential safety hazard He causes dihydroartemisinine.Existing agitated reactor only carries out temperature controlling through feeding cooling liquid in the chuck that outside kettle, is provided with, and this agitated reactor obviously can't satisfy the requirement to the rapid reduction of hydroboration reduction reaction system temperature.
Summary of the invention
technical problem to be solved by this invention is the deficiency that overcomes prior art, and a kind of preparation dihydroartemisinine agitated reactor is provided, and reaches the purpose that material in the kettle is lowered the temperature rapidly.
For solving the problems of the technologies described above, the present invention takes following technical scheme:
a kind of preparation dihydroartemisinine agitated reactor; It comprises the still frame, is erected at kettle and agitating device on the still frame; Wherein kettle comprises still body and the kettle cover that is tightly connected with the still body; The bottom of still body is provided with discharging opening; Kettle cover is provided with charging aperture; Also be provided with the chuck of water inlet and delivery port in still body periphery, described agitated reactor also comprises the condenser coil that is arranged in the kettle, and this condenser coil has and stretches out the condensed fluid inlet that kettle is provided with and export with condensed fluid.
preferably, condensed fluid inlet exports downside and the upside that lays respectively at the still body with condensed fluid, the centerline direction of condenser coil is consistent with the short transverse of still body.
more preferably, the material of condenser coil is a titanium steel.
further embodiment according to the present invention: agitating device is a mechanical stirring device; It comprises fire-proof motor, decelerator, agitator; Agitator wherein comprises the shaft that is connected with decelerator and is arranged on the stirring vane on the shaft, and condenser coil is positioned at the periphery of agitator.
Because the enforcement of above technical scheme, the present invention compared with prior art has following advantage:
agitated reactor of the present invention; Outside kettle, being provided with the chuck that can lead to condensed fluid; Also in kettle, also be provided with condenser coil; When feeding condensed water or other condensed fluid in the condenser coil; Heat exchange directly takes place in the material in condensate liquid physical efficiency and the kettle, and material in the kettle is cooled off fast.Therefore, agitated reactor of the present invention, its cooling rate is fast, and when being used to prepare dihydroartemisinine, security is good, and can effectively avoid the dihydroartemisinine degraded.
Description of drawings
are done further detailed explanation below in conjunction with accompanying drawing and concrete embodiment to the present invention.
Fig. 1 is the structural representation of agitated reactor of the present invention;
wherein: 1, still frame; 2, kettle; 20, still body; 200, discharging opening; 21, kettle cover; 210, charging aperture; 3, agitating device; 30, anti-riot motor; 31, decelerator; 32, shaft; 4, chuck; 40, water inlet; 41, delivery port; 5, condenser coil; 50, condensed fluid inlet; 51, condensed fluid outlet; 6, visor hand hole; 7, the anti-riot lamp of looking; 8, feed pipe; 9, cleaning fluid pipe.
The specific embodiment
as shown in Figure 1; Agitated reactor according to present embodiment; It comprises still frame 1; Be erected at kettle 2 and agitating device 3 on the still frame 1; Wherein kettle 2 comprises still body 20 and the kettle cover 21 that is tightly connected with still body 20; The bottom of still body 20 is provided with discharging opening 200; Kettle cover 21 is provided with charging aperture 210; Also be provided with the chuck 4 of water inlet 40 and delivery port 40 in still body 20 peripheries; This agitated reactor also comprises the condenser coil 5 that is arranged in the kettle 2; This condenser coil 5 has the condensed fluid inlet 50 and condensed fluid outlet 51 that stretches out kettle 2 settings; In addition; For the needs of reality, also on kettle cover 21, be provided with visor hand hole 6; The explosion-proof lamp 7 of looking; And cleaning fluid inlet pipe 9 etc.
Condensed fluid inlet 50 of
aforesaid reaction vessel and condensed fluid outlet 51 downside and the upsides that lay respectively at still body 20; The centerline direction of condenser coil 5 is consistent with the short transverse of still body 2; In order to use the material of condenser coil 5 to be titanium steel for a long time; Simultaneously; Agitating device 3 in the present embodiment is a mechanical stirring device; It comprises fire-proof motor 30; Decelerator 31; Agitator; Agitator wherein comprises the shaft 32 that is connected with decelerator 31 and is arranged on the stirring vane (not shown) on the shaft 32; And condenser coil 5 is positioned at the periphery of agitator, does not influence the operate as normal of agitator.
Agitated reactor in
present embodiment; Outside kettle 2, being provided with the chuck 4 that can lead to condensed fluid; Also in kettle 2, also be provided with condenser coil 5; When feeding condensed water or other condensed fluid in the condenser coil 5; Heat exchange directly takes place in the material in condensate liquid physical efficiency and the kettle 2, and material in the kettle 2 is cooled off fast.Therefore, agitated reactor of the present invention, its cooling rate is fast, and when being used to prepare dihydroartemisinine, security is good, and can effectively avoid the dihydroartemisinine degraded.
More than the present invention has been done detailed description; Its purpose is to allow the personage that is familiar with this art can understand content of the present invention and implements; Can not limit protection scope of the present invention with this; All equivalences of doing according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention
Claims (5)
1. one kind prepares the dihydroartemisinine reactor; It comprises still frame (1), is erected at kettle (2) and agitating device (3) on the said still frame (1); Said kettle (2) comprises still body (20) and the kettle cover (21) that is tightly connected with still body (20); The bottom of said still body (20) is provided with discharging opening (200); Said kettle cover (21) is provided with charging aperture (210); Also be provided with the chuck (4) of water inlet (40) and delivery port (41) in said still body (20) periphery; It is characterized in that: described reactor also comprises the condenser coil (5) that is arranged in the said kettle (2), and said condenser coil (5) has the condensed fluid inlet (50) and the condensed fluid outlet (51) of stretching out described kettle (2) setting.
2. preparation dihydroartemisinine agitated reactor according to claim 1 is characterized in that: described condensed fluid inlet (50) and condensed fluid outlet (51) lay respectively at the downside and the upside of described still body (20).
3. preparation dihydroartemisinine agitated reactor according to claim 1 is characterized in that: the centerline direction of described condenser coil (5) is consistent with the short transverse of described still body (20).
4. preparation dihydroartemisinine agitated reactor according to claim 1 is characterized in that: the material of described condenser coil (5) is a titanium steel.
5. according to the described preparation dihydroartemisinine of each claim agitated reactor in the claim 1 to 4; It is characterized in that: described agitating device (3) is a mechanical stirring device; It comprises fire-proof motor (30), decelerator (31), agitator; Said agitator comprises the shaft (32) that is connected with said decelerator (31) and is arranged on the stirring vane on the said shaft (32) that described condenser coil (5) is positioned at the periphery of described agitator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102578900A CN102350292A (en) | 2011-09-02 | 2011-09-02 | Reaction kettle for preparing dihydroartemisinin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102578900A CN102350292A (en) | 2011-09-02 | 2011-09-02 | Reaction kettle for preparing dihydroartemisinin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102350292A true CN102350292A (en) | 2012-02-15 |
Family
ID=45574000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011102578900A Pending CN102350292A (en) | 2011-09-02 | 2011-09-02 | Reaction kettle for preparing dihydroartemisinin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102350292A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102809234A (en) * | 2012-08-14 | 2012-12-05 | 张家港市金腾化工机械制造有限公司 | Simple refrigerating unit |
| CN105833818A (en) * | 2016-03-27 | 2016-08-10 | 夏治政 | Novel reaction kettle |
| CN107886830A (en) * | 2017-11-28 | 2018-04-06 | 河南莱帕克化工设备制造有限公司 | Intermittent reaction production line instructional device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2176822Y (en) * | 1993-11-03 | 1994-09-14 | 陈邦汉 | Solid heat-transferring reacting pot |
| US5977421A (en) * | 1997-09-03 | 1999-11-02 | Hanson; Curtiss D. | Pyrolysis method for increasing limonene production and novel oven to facilitate such method |
| CN2616537Y (en) * | 2002-05-13 | 2004-05-19 | 大连铁道学院 | Organic compound synthesizing apparatus |
| CN201711154U (en) * | 2010-07-10 | 2011-01-19 | 恩施济源药业科技开发有限公司 | Reactor for preparing dihydroartemisinine |
| CN202207596U (en) * | 2011-09-02 | 2012-05-02 | 江苏斯威森生物医药工程研究中心有限公司 | Reaction kettle for preparing dihydroartemisinin |
-
2011
- 2011-09-02 CN CN2011102578900A patent/CN102350292A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2176822Y (en) * | 1993-11-03 | 1994-09-14 | 陈邦汉 | Solid heat-transferring reacting pot |
| US5977421A (en) * | 1997-09-03 | 1999-11-02 | Hanson; Curtiss D. | Pyrolysis method for increasing limonene production and novel oven to facilitate such method |
| CN2616537Y (en) * | 2002-05-13 | 2004-05-19 | 大连铁道学院 | Organic compound synthesizing apparatus |
| CN201711154U (en) * | 2010-07-10 | 2011-01-19 | 恩施济源药业科技开发有限公司 | Reactor for preparing dihydroartemisinine |
| CN202207596U (en) * | 2011-09-02 | 2012-05-02 | 江苏斯威森生物医药工程研究中心有限公司 | Reaction kettle for preparing dihydroartemisinin |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102809234A (en) * | 2012-08-14 | 2012-12-05 | 张家港市金腾化工机械制造有限公司 | Simple refrigerating unit |
| CN102809234B (en) * | 2012-08-14 | 2014-08-27 | 张家港市金腾化工机械制造有限公司 | Simple refrigerating unit |
| CN105833818A (en) * | 2016-03-27 | 2016-08-10 | 夏治政 | Novel reaction kettle |
| CN107886830A (en) * | 2017-11-28 | 2018-04-06 | 河南莱帕克化工设备制造有限公司 | Intermittent reaction production line instructional device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN201848251U (en) | Agitated reactor with stirring and liquid feeding device | |
| CN203916668U (en) | A kind of water-based impregnation material reactor of homogeneous heating | |
| CN103949083B (en) | A kind of crystallizing tank | |
| CN107737561A (en) | A kind of high chelating agent process units of product batches quality | |
| CN102350292A (en) | Reaction kettle for preparing dihydroartemisinin | |
| CN102423543A (en) | Vinpocetine special-purpose crystallization pot | |
| CN205146226U (en) | Agitating unit is smashed in pharmacy | |
| CN106512892A (en) | Continuous reaction device | |
| CN202207596U (en) | Reaction kettle for preparing dihydroartemisinin | |
| CN202876812U (en) | Reaction kettle for producing petrochemical products | |
| CN202376984U (en) | Reaction kettle | |
| CN205295320U (en) | Mechanical stirring formula fermentation cylinder | |
| CN204307631U (en) | A kind ofly extract the special reactor of marine alga intermediate | |
| CN105771828B (en) | A kind of impact flow reactor for reactive liquid solution | |
| CN205288414U (en) | Reaction kettle | |
| CN205307854U (en) | Crystallizer is used in cefotaxime sodium preparation | |
| CN201729787U (en) | Polypropylene copolymerization reactor | |
| CN207838846U (en) | A kind of preparation facilities of deinking agent | |
| CN203253428U (en) | Full-automatic multi-kettle charging production system for producing scale-inhibiting dispersion polymer | |
| CN209476283U (en) | A kind of reaction kettle | |
| CN207483726U (en) | A kind of proportion of crop planting seedling medium stirring unit | |
| CN208346590U (en) | A kind of high target SBS modified asphalt preparation device | |
| CN208667143U (en) | A kind of automatic forced circulating and evaporating crystallization apparatus | |
| CN207680609U (en) | Polymer reactor | |
| CN205761162U (en) | A kind of reacting by heating still |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120215 |