CN102335207A - Composition containing magnesium aluminum silicate and volatile oil - Google Patents
Composition containing magnesium aluminum silicate and volatile oil Download PDFInfo
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- CN102335207A CN102335207A CN2010102356811A CN201010235681A CN102335207A CN 102335207 A CN102335207 A CN 102335207A CN 2010102356811 A CN2010102356811 A CN 2010102356811A CN 201010235681 A CN201010235681 A CN 201010235681A CN 102335207 A CN102335207 A CN 102335207A
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Abstract
The invention relates to a volatile oil composition, which is characterized in that: magnesium aluminum silicate is contained in the composition. When traditional volatile oil is prepared into a solid preparation, a cyclodextrin or cyclodextrin derivative clathration method is adopted, such that the volatile oil is solidified, or volatilization is reduced. During a clathrate preparing process, the clathration time in water is long. Therefore, during a clathrate drying process, the volatile oil is easy to be volatilized, such that the clathration rate and the recovery rate of the clathrate are low. According to the invention, magnesium aluminum silicate is adopted as an absorbent, such that volatile oil can be well absorbed. The technical process is simple, the absorption rate is high, and the stability is high. The composition provided by the invention can be used in fields of medicines and foodstuffs.
Description
Background of invention
Volatile oil is claimed quintessence oil again, is to be present in the plant one type of that can obtain with vapor distillation and the not miscible volatility oily composition of water, often has special aromatic odor.In Chinese medicine, there are many medical materials to contain volatile oil component, have very strong pharmacologically active usually.Like Radix Bupleuri volatile oil the effect of well bringing down a fever is arranged; Refrigerant, antiinflammation that Oleum menthae has; Oleum Bulbus Allii can be treated bronchitis, pneumonia and fungal infection; That oil of Rhizoma Zingiberis Recens has is analgesic, analgesia, sedation, and Rhizoma Chuanxiong oil has the expansion of cerebral vascular effect, and the volatile oil of Olibanum, Myrrha has effect of good blood circulation promoting and blood stasis dispelling, microcirculation improvement or the like.
The at normal temperatures easy evaporable grease of volatile oil for from plant, extracting, it contains chemical compounds such as aliphatic, aromatic series, terpenoid.
Because volatile oil volatilizees easily, often need adopt special method that it is processed into solid powder, could improve stability (minimizing volatile oils).Because volatile oil is liquid, also only is processed into pressed powder and could conveniently processes solid preparations such as tablet, capsule simultaneously.
At present, generally adopt the derivant of cyclodextrin or cyclodextrin to carry out enclose volatile oil, this enclose can make buttery volatile oil become into solid by liquid, the volatilization that can slow down volatile oil simultaneously.For example CN200910309523 discloses a kind of traditional medicine volatile oil clathrate and preparation method thereof; This traditional medicine volatile oil clathrate is the Benexate Hydrochloride of Flos Lonicerae volatile oil, Rhizoma Curcumae volatile oil and Herba Houttuyniae volatile oil; Wherein the weight proportion of Flos Lonicerae volatile oil, Rhizoma Curcumae volatile oil, Herba Houttuyniae volatile oil and beta-schardinger dextrin-is 2～4 parts of Flos Lonicerae volatile oils; 2～6 parts of Rhizoma Curcumae volatile oils, 1～2 part of Herba Houttuyniae volatile oil, 20～100 parts of beta-schardinger dextrin-s.The method of enclose is the enclose aqua-solution method.But adopt this patent enclose Flos Lonicerae volatile oil, Rhizoma Curcumae volatile oil and Herba Houttuyniae volatile oil content to be up to 10%.
CN200710125223 discloses a kind of clathrate that contains Rhizoma Atractylodis Macrocephalae volatile oil and preparation method thereof.Wherein, the enclose material is a HP-, and the mass ratio of itself and Rhizoma Atractylodis Macrocephalae volatile oil is 5: 1～30: 1, preferred 10: 1.The clathrate method for preparing is polishing or ultrasonic method.Said clathrate can further be processed solid, liquid, medicinal dosage forms such as tablet, suspensoid as required.But wherein Rhizoma Atractylodis Macrocephalae volatile oil maximum amount in clathrate is 8.3%, needs processes such as drying in the process of enclose, inevitably can increase the loss of volatile oil.
CN200410052894 discloses the clathrate colloid mill method for preparing of a kind of natural plant volatile oil-Rhizoma Chuanxiong volatile oil and beta-schardinger dextrin-.Comprise the steps: Rhizoma Chuanxiong volatile oil, water and beta-schardinger dextrin-were ground in business-like colloid mill 2～30 minutes, adopt conventional method from grinding product, to collect the Rhizoma Chuanxiong volatile oil Benexate Hydrochloride then.Method of the present invention, easy and simple to handle, preparation time is short.But the Rhizoma Chuanxiong volatile oil utilization rate only is 65.0% (other is for particularly losing in the dry run in inclusion process), and the clathrate oil content is about 9.0%.
CN200810106174 discloses inclusion compound of water-soluble derivatives of cyclodextrin of volatile oil and preparation method thereof.It can carry out in ethanol, has avoided adopting other organic solvent commonly used such as acetone, chloroform, methanol, the tert-butyl alcohol and homologue thereof, isopropyl alcohol, has avoided organic solvent residual, and can carry out at low temperatures.But in saturated process, adopted organic solvent, also can contain the deleterious organic solvent of trace in the finished product, organic solvent also can be taken away part volatile oil in evaporable process simultaneously, causes volatile oil content to descend.
CN200610054620 the present invention relates to the even matter inclusion method of volatile oil beta-cyclodextrin.But need higher temperature 30-60 ℃, volatile oil can loss in the process of enclose.
It is thus clear that, adopt the technology of cyclodextrin inclusion compound volatile oil inevitably to have following problem:
1, the cyclodextrin that needs larger proportion, the ratio of cyclodextrin and volatile oil generally all greater than 5: 1, is up to 200: 1, and the content of volatile oil in clathrate is generally less than 10%.
2, in the process of enclose, often need heat drying or vacuum drying, volatile oil also can volatilize in exsiccant process, causes the response rate of inclusion essential oil not high.
3, inclusion process complex process, the influence factor is many, and the time is long, and cost is high.
Research worker of the present invention; In the solidified process of development volatile oil; It is unexpected that the employing Magnesiumaluminumsilicate adsorbing volatilizing oil of finding under the situation of less Magnesiumaluminumsilicate and volatile oil ratio, just can make volatile oil powdered; Be very easy to be used for tabletting or filled capsules, can obtain the preparation of high-load volatile oil.Simultaneously, the preparation process is simple, has reduced the volatilization of volatile oil in technical process, and the volatile oil response rate is high than the method for cyclodextrin inclusion compound, and volatile oil Magnesiumaluminumsilicate adsorbate has good physical stability simultaneously.Therefore, the technical scheme of technical scheme of the present invention and traditional cyclodextrin inclusion compound volatile oil has advance and practicality more.
Summary of the invention
The present invention relates to a kind of compositions that contains volatile oil, be characterised in that in this combination and contain Magnesiumaluminumsilicate.
Magnesiumaluminumsilicate of the present invention, English magnisium aluminometasilicate by name.
The mass ratio of described Magnesiumaluminumsilicate of this law and volatile oil is 0.4: 1-10: 1, further be optimized for 0.6: 1-5: and 1, more one-step optimization is 0.8: 1-2: 1.
Volatile oil of the present invention, early existing argumentation the in books such as Chinese medicine and Chemistry for Chinese Traditional Medicine.
Volatile oil according to the invention is one or more type mixture of ingredients, general a kind of volatile oil often contain tens kinds to one, 200 kind of composition, wherein account for bigger component with certain or several composition.It basic composition is aliphatic, aromatic series and terpenoid.
Volatile oil of the present invention, available following method is extracted from crude drug:
The way of distillation this be the most frequently used method, can be divided into common hydrodistillation and steam distillation.
2. solvent extraction method utilizes lower boiling organic solvent, and like heating extraction in apparatus,Soxhlet's such as petroleum ether, ether, extracting solution boils off solvent and promptly gets volatile oil.
3. supercritical CO
2Extraction.
4. the valuable volatile oil of absorption process; Can adopt 3 parts of mixture of axunge of no stink to come absorption extraction like Oleum Rosae Rugosae, Flos Jasmini Sambac oil, obtain " face cream ", can supply perfume industry to use with this with 2 parts of Adeps Bovis seu Bubalis; Also can add dehydrated alcohol and stir altogether, alcoholic solution pressure reducing and steaming ethanol promptly gets absolute oil.
5. milling process contains the more crude drug of volatile oil, and like Pericarpium Citri tangerinae, Fericarpium Citri Limoniae, Pericarpium Citri junoris etc., available mechanical expression method pushes volatile oil out, also comprises impurity such as moisture and histiocyte in this method gained volatile oil, must be through centrifugal, and distillation, dehydrations etc. are refining.
The at normal temperatures grease of easy volatile oil of volatile oil of the present invention for from Chinese medicine, extracting, it contains chemical compounds such as aliphatic, aromatic series, terpenoid.
Volatile oil of the present invention can be volatility oily composition in one or more plants or the Chinese medicine.
The kind that can extract volatile oil in the Chinese medicine is a lot, and volatile oil of the present invention extracts from following crude drug but is not limited to following crude drug:
Pinaceae: Pinus tabuliformis, Pinus massoniana Lamb;
Cupressaceae: Cacumen Platycladi;
Magnoliaceae: Cortex Magnoliae Officinalis, Flos Magnoliae, Fructus Schisandrae Chinensis, Fructus Anisi Stellati;
Lauraceae: Cortex Cinnamomi, Lignum cinnamomi camphorae, Fructus Litseae;
Rutaceae: Pericarpium Citri Reticulatae, Pericarpium Citri junoris, Fructus Aurantii Immaturus, Pericarpium Zanthoxyli, Fructus Evodiae, CitrusaurantiumL.Var.amara Engl., Fructus Citri;
Myrtaceae: Folium eucalypti globueli (Eucalyptus globulus Labill.), Flos Caryophylli;
Umbelliferae: Radix Angelicae Sinensis, Fructus Foeniculi, Rhizoma Chuanxiong, GAOMU, Fructus Cnidii, Resina Ferulae, windproof;
Labiatae: Herba Menthae, Herba Menthae Rotundifoliae, Folium Perillae, Herba Pogostemonis, Herba Schizonepetae, Herba Moslae;
Valerianaceae: Radix Et Rhizoma Nardostachyos, Rhizoma et radix valerianae, Rhizoma valerianae latifoliae;
Compositae: Herba Artemisiae Scopariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, the Radix Aucklandiae;
Zingiberaceae: Fructus Amomi, Fructus Amomi Rotundus, Fructus Tsaoko, Rhizoma Curcumae, Rhizoma Zingiberis Recens, Semen Alpiniae Katsumadai, Rhizoma Alpiniae Officinarum, Fructus Alpiniae Oxyphyllae.
In addition, in some crude drug of Saururaceae, Ranunculaceae, Rosaceae, thymelaeceae, Ericaceae, Oleaceae, asclepiadaceae, grass family, Cyperaceae, Araeceae etc., also contain more rich volatile oil component
Volatile oil of the present invention is selected from but is not limited to Oleum Ocimi Gratissimi, Oleum Anisi Stellati, patchouli oil, Oleum Cinnamomi, Oleum Viticis Negundo, Oleum Terebinthinae, Oleum Curcumae, Oleum Eucalypti, Oleum Rhododendri Daurici, Oleum menthae, Herba Houttuyniae volatile oil, Flos Lonicerae volatile oil, Rhizoma Chuanxiong volatile oil, turmeric oil, Radix Bupleuri volatile oil, limonene, Radix Oenotherae erythrosepalae oil, Folium perillae acutae oil, Fructus Forsythiae oil, Oleum Caryophylli, wintergreen oil, Radix Angelicae Sinensis oil, Rhizoma Atractylodis Macrocephalae oil, Fructus Amomi oil, oil of Rhizoma Zingiberis Recens, Oleum Bulbus Allii, Rhizoma Chuanxiong oil, Myrrha, Radix Angelicae Dahuricae oil, Rhizoma Acori Graminei oil, Rhizoma Atractylodis oil, Herba Moslae oil, Herba Artemisiae Annuae oil, Oleum Citri Reticulatae, Oleum lavandula angustifolia, Fructus Citri Limoniae oil, citronella oil, Oleum Menthae Rotundifoliae, Radix Aucklandiae oil, nutgrass galingale oil, chilli oil, Oleum Pelargonii Graveolentis, Oleum Hippophae, fruit of cubeb litsea tree oil, Oleum Terebinthinae, Oleum Camphora, Lignum Dalbergiae Odoriferae oil, Oleum Ricini, Radix Et Rhizoma Nardostachyos oil, Flos Magnoliae oil, Oleum Asari, Flos Chrysanthemi volatile oil, Resina Ferulae volatile oil.
Volatile oil of the present invention is the mixture of one or more crude drug volatile oil.
The described volatile oil of this law can be the mixture of volatile oil of a kind of medical material or the extraction of multiple crude drug.
The preparation of drug combination method that contains volatile oil of the present invention is at first mixed Magnesiumaluminumsilicate and volatile oil, stirs, and obtains the Magnesiumaluminumsilicate adsorbed product of volatile oil.
The adsorbed product of the Magnesiumaluminumsilicate of volatile oil can further add other adjuvant, is prepared into pharmaceutically acceptable dosage form.
The Magnesiumaluminumsilicate adsorbed product of volatile oil is filled capsules directly, perhaps adds other acceptable accessories filled capsules together.The Magnesiumaluminumsilicate adsorbed product of volatile oil can add other acceptable accessories tabletting simultaneously.
The English of Magnesiumaluminumsilicate of the present invention Magnesium Aluminometasilicate by name or Magnesiumaluminum silicate or Aluminium Magnesium Silicate.
Magnesiumaluminumsilicate of the present invention can perhaps process for natural Magnesiumaluminumsilicate for natural aluminium silicate magnesium, also can be synthetic Magnesiumaluminumsilicate, the Neusilin that for example sells on the market, Carrisorb etc., wherein preferred synthetic Magnesiumaluminumsilicate.
Acceptable accessories of the present invention includes, but are not limited to filler, disintegrating agent, lubricant.
Pharmaceutical composition active component of the present invention can also contain pharmaceutically acceptable other active component except that volatile oil.
Embodiment
Below be embodiments of the invention, but do not represent that the present invention is limited to following examples.
Embodiment 1
Flos Lonicerae volatile oil 30g
Rhizoma Curcumae volatile oil 40g
Herba Houttuyniae volatile oil 10g
Synthetic silicic acid magnalium (Neusilin) 80g
The Oleum menthae element of recipe quantity is added in the Magnesiumaluminumsilicate of recipe quantity, mix, 24 mesh sieves are granulated.Obtain the Magnesiumaluminumsilicate adsorbate of solid-state volatile oil, this adsorbate can be used for filled capsules or add other acceptable accessories tabletting.Volatile oil content about 48.8% in this adsorbate.
Embodiment 2
Rhizoma Atractylodis Macrocephalae volatile oil 100g
Synthetic silicic acid magnalium (Neusilin) 80g
The Rhizoma Atractylodis Macrocephalae volatile oil and the Magnesiumaluminumsilicate of recipe quantity are mixed, and 24 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of solid-state Rhizoma Atractylodis Macrocephalae volatile oil.The volatile oil content of this adsorbate reaches 53.7%.
This adsorbate can add pharmaceutically, and the acceptable adjuvant is prepared into pharmaceutically acceptable dosage form, for example capsule, tablet and powder agent etc.
Embodiment 3
Rhizoma Chuanxiong oil 100g
Synthetic silicic acid magnalium (Neusilin) 120g
The Rhizoma Chuanxiong oil and the Magnesiumaluminumsilicate of recipe quantity are mixed, and 24 mesh sieves are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of solid-state Rhizoma Chuanxiong oil.Volatile oil contents is 44.0%.
This adsorbate can add pharmaceutically, and the acceptable adjuvant is prepared into pharmaceutically acceptable dosage form, for example capsule, tablet and granule etc.
Embodiment 5
Radix Bupleuri volatile oil 60g
Long-pending real volatile oil 15g
Volatile oil of Radix Aucklandiae 15g
Pericarpium Citri Reticulatae volatile oil 15g
Synthetic silicic acid magnalium (Neusilin) 100g
With the volatile oil and the Magnesiumaluminumsilicate mix homogeneously of recipe quantity, 30 mesh sieves are granulated excessively, obtain the Magnesiumaluminumsilicate adsorbate of solid-state Radix Bupleuri, long-pending reality, the Radix Aucklandiae and Pericarpium Citri Reticulatae, and wherein volatile oil content is 50.2%.
This adsorbate can add pharmaceutically, and the acceptable adjuvant is prepared into pharmaceutically acceptable dosage form, for example capsule, tablet and granule etc.
Embodiment 6
Flos Caryophylli volatile oil 100g
Magnesiumaluminumsilicate (Neusilin) 80g
With the Fructus Bruceae volatile oil and the Magnesiumaluminumsilicate mix homogeneously of recipe quantity, cross 30 mesh sieves and granulate, obtain the Magnesiumaluminumsilicate adsorbate of solid-state Flos Caryophylli volatile oil, wherein volatile oil content is 53.8%.
This adsorbate can add pharmaceutically, and the acceptable adjuvant is prepared into pharmaceutically acceptable dosage form, for example capsule, tablet and granule etc.
Embodiment 7
Oil of Herba Pogostemonis 20g
Oleum Citri Reticulatae 20g
Oleum Cinnamomi 20g
Rhizoma Atractylodis oil 20g
Cortex Magnoliae Officinalis oil 20g
Radix Angelicae Dahuricae oil 20g
Synthetic silicic acid magnalium (Neusilin) 100g
With the volatile oil and the Magnesiumaluminumsilicate mix homogeneously of recipe quantity, 30 eye mesh screens are granulated excessively, obtain the Magnesiumaluminumsilicate adsorbate of solid-state Radix Bupleuri, long-pending reality, the Radix Aucklandiae and Pericarpium Citri Reticulatae, and wherein volatile oil content is 53.2%.
This adsorbate can add other adjuvant and be prepared into capsule, tablet and granule etc.
Embodiment 8
Oleum Rhododendri Daurici 100g
Synthetic silicic acid magnalium (Neusilin) 100g
Starch 80g
Microcrystalline Cellulose 96g
Polyvinylpolypyrrolidone 20
Magnesium stearate 4g
With the Oleum Rhododendri Daurici and the Magnesiumaluminumsilicate mix homogeneously of recipe quantity, cross 30 eye mesh screens and granulate, obtain the Magnesiumaluminumsilicate adsorbate of solid-state Oleum Rhododendri Daurici, wherein volatile oil content is 48.6%.
The Magnesiumaluminumsilicate adsorbate of Oleum Rhododendri Daurici, starch, microcrystalline Cellulose, polyvinylpolypyrrolidone and magnesium stearate mix homogeneously, tabletting, every 0.4g, every contains Oleum Rhododendri Daurici 0.1g.
Embodiment 9
Oleum Terebinthinae 10g
Natural aluminium silicate magnesium 50g
With the Oleum Terebinthinae and the Magnesiumaluminumsilicate mix homogeneously of recipe quantity, 30 eye mesh screens are granulated excessively, obtain the Magnesiumaluminumsilicate adsorbate of solid-state Radix Bupleuri, long-pending reality, the Radix Aucklandiae and Pericarpium Citri Reticulatae, and wherein volatile oil content is 15.3%.
This adsorbate can add other adjuvant and be prepared into capsule, tablet and powder agent etc.
Embodiment 10
Oleum Viticis Negundo 20g
Natural aluminium silicate magnesium 200g
Sucrose 775g
Fructus Citri tangerinae essence 5g
With Oleum Viticis Negundo, Magnesiumaluminumsilicate mix homogeneously, 30 screen clothes are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of Oleum Viticis Negundo, and volatile oil content is 7.5%.
Add sucrose and Fructus Citri tangerinae essence mix homogeneously, packing, every bag of 1.1g contains the about 0.02g of Oleum Viticis Negundo.
Embodiment 11
The plain 100g of Oleum menthae
Synthetic silicic acid magnalium (Neusilin) 80g
Polyvinylpolypyrrolidone 10g
Dextrin 150g
Sucrose 56g
Magnesium stearate 4g
1000
Plain and the Magnesiumaluminumsilicate mix homogeneously with Oleum menthae, 30 eye mesh screens are granulated, and obtain the plain Magnesiumaluminumsilicate adsorbate of Oleum menthae, and volatile oil content is 54.2%.
Add polyvinylpolypyrrolidone, dextrin, sucrose and magnesium stearate mix homogeneously, tabletting, the every heavy 0.4g of sheet contains the about 0.1g of volatile oil.
Embodiment 12
Limonene 100g
Synthetic silicic acid magnalium (Neusilin) 80g
Magnesium stearate 1.8g
1000
With limonene and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain limonene Magnesiumaluminumsilicate adsorbate, and volatile oil content is 54.0%.
Magnesium stearate is added in the limonene Magnesiumaluminumsilicate adsorbate, mix homogeneously, filled capsules, every 0.18g contains limonene 0.1g.
Embodiment 13
Chilli oil 50g
Oil of Rhizoma Zingiberis Recens 50g
Synthetic silicic acid magnalium (Neusilin) 80g
With chilli oil, oil of Rhizoma Zingiberis Recens and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of chilli oil and oil of Rhizoma Zingiberis Recens, and volatile oil content is 55%.This adsorbate can be made food or food additive.
Embodiment 14
Oleum Bulbus Allii 100g
Synthetic silicic acid magnalium (Neusilin) 50g
With Oleum Bulbus Allii and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain Oleum Bulbus Allii Magnesiumaluminumsilicate adsorbate, and volatile oil content is 64.4%.This adsorbate can be used as and is used for making food additive (flavoring agent) or health product.
Embodiment 15
Oleum Anisi Stellati 100g
Synthetic silicic acid magnalium (Neusilin) 80g
With Oleum Anisi Stellati and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain Oleum Anisi Stellati Magnesiumaluminumsilicate adsorbate, and volatile oil content is 55%.This adsorbate can be used as and is used for making food additive (flavoring agent) or medicine.
Embodiment 16
Folium perillae acutae oil 100g
Synthetic silicic acid magnalium (Neusilin) 70g
With Folium perillae acutae oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain Folium perillae acutae oil Magnesiumaluminumsilicate adsorbate, and volatile oil content is 56.8%.
Embodiment 17
Fructus Forsythiae oil 100g
Synthetic silicic acid magnalium (Neusilin) 60g
With Fructus Forsythiae oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain Fructus Forsythiae oil Magnesiumaluminumsilicate adsorbate, and volatile oil content is 60.6%.
Embodiment 18
Wintergreen oil 100g
Synthetic silicic acid magnalium (Neusilin) 80g
With wintergreen oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain wintergreen oil Magnesiumaluminumsilicate adsorbate, and volatile oil content is 54%.
Embodiment 19
Radix Angelicae Sinensis oil 100g
Synthetic silicic acid magnalium (Neusilin) 40g
With Radix Angelicae Sinensis oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain Radix Angelicae Sinensis oil Magnesiumaluminumsilicate adsorbate, and volatile oil content is 70%.
Embodiment 20
Fructus Citri Limoniae oil 100g
Synthetic silicic acid magnalium (Neusilin) 80g
With Fructus Citri Limoniae oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain Fructus Citri Limoniae oil Magnesiumaluminumsilicate adsorbate, and volatile oil content is 53.7%.
Embodiment 21
Flos Magnoliae oil 100g
Synthetic silicic acid magnalium (Neusilin) 100g
With Flos Magnoliae oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of Flos Magnoliae oil, and volatile oil content is 48.4%.
Embodiment 22
Rhizoma Acori Graminei oil 100g
Synthetic silicic acid magnalium (Neusilin) 80g
With Rhizoma Acori Graminei oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of Rhizoma Acori Graminei oil, and volatile oil content is 53.6%.
Embodiment 23
Herba Artemisiae Annuae oil 100g
Synthetic silicic acid magnalium (Neusilin) 30g
With Herba Artemisiae Annuae oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of Herba Artemisiae Annuae oil, and volatile oil content is 75%.
Embodiment 24
Nutgrass galingale oil 100g
Synthetic silicic acid magnalium (Neusilin) 80g
With nutgrass galingale oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of nutgrass galingale oil, and volatile oil content is 55%.
Embodiment 25
Oleum Hippophae 100g
Synthetic silicic acid magnalium (Neusilin) 200g
With Oleum Hippophae and Magnesiumaluminumsilicate mix homogeneously, 30 screen clothes are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of Oleum Hippophae, and volatile oil content is 31.6%.
Embodiment 26
Fruit of cubeb litsea tree oil 100g
Synthetic silicic acid magnalium (Neusilin) 120g
With fruit of cubeb litsea tree oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of fruit of cubeb litsea tree oil, and volatile oil content is 43.6%.
Embodiment 27
Oleum Camphora 100g
Synthetic silicic acid magnalium (Neusilin) 110g
With Oleum Camphora and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of Oleum Camphora, and volatile oil content is 45.5%
Embodiment 28
Radix Oenotherae erythrosepalae oil 100g
Synthetic silicic acid magnalium (Neusilin) 100g
With Radix Oenotherae erythrosepalae oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of Radix Oenotherae erythrosepalae oil, and volatile oil content is 47.2%
Embodiment 29
Oil of Flos Chrysanthemi 100g
Synthetic silicic acid magnalium (Neusilin) 90g
With oil of Flos Chrysanthemi and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of oil of Flos Chrysanthemi, and volatile oil content is 52%.
Embodiment 30
Lignum Dalbergiae Odoriferae oil 100g
Synthetic silicic acid magnalium (Neusilin) 80g
With Lignum Dalbergiae Odoriferae oil and Magnesiumaluminumsilicate mix homogeneously, 30 eye mesh screens are granulated, and obtain the Magnesiumaluminumsilicate adsorbate of Lignum Dalbergiae Odoriferae oil, and volatile oil content is 52.9%.
The comparative example:
Comparative example 1 is with reference to the Benexate Hydrochloride of CN200910309523 Flos Lonicerae volatile oil, Rhizoma Curcumae volatile oil and Herba Houttuyniae volatile oil.
Comparative example 2 discloses a kind of clathrate that contains Rhizoma Atractylodis Macrocephalae volatile oil and preparation method thereof with reference to CN200710125223.Wherein, the enclose material is a HP-
The comparative example 3, disclose the clathrate colloid mill method for preparing of a kind of natural plant volatile oil-Rhizoma Chuanxiong volatile oil and beta-schardinger dextrin-with reference to CN200410052894
Comparative example 4 has prepared the Oleum Caryophylli cyclodextrin clathrate with reference to CN200810106174
Comparative example 5 has prepared Radix Bupleuri volatile oil, long-pending real volatile oil, volatile oil of Radix Aucklandiae and Pericarpium Citri Reticulatae volatile oil cyclodextrin clathrate with reference to CN200610054620.
The volatile oil Magnesiumaluminumsilicate adsorbate of embodiment 1-30 and the volatile oil clathrate compound of comparative example 1-5 are opened wide placement 5 days in room temperature, and the physical stability of the volatile oil of two kinds of technology of investigation is measured before the placement and placement back volatile oil contents, counting loss.
Above comparative illustration adopts scheme of the present invention can reduce the loss of volatile oil in solidified process, has higher volatile oil content, has good physical stability simultaneously.
More than be embodiments of the invention, but do not represent that the present invention is limited to above embodiment.
The variation of the embodiment of the invention perhaps becomes obvious behind the embodiment for the general technical staff in this area after reading the bright technology path of this law.Therefore, the institute that the present invention includes the theme described in this paper accompanying claims changes and equivalent.
Volatile oil of the present invention is not limited to the kind described in the embodiment, because the common inherent characteristic of volatile oil promptly is liquid at normal temperatures, and volatilization easily.Therefore adopt general inclusion technique with inevitably running into the clathrate process complicacy in the process of inclusion essential oil; The process volatile oil of enclose is loss and the unfavorable problem of physical stability easily; And technical scheme of the present invention has solved the problems referred to above, therefore has good practicality and versatility.
Claims (10)
1. a compositions is characterized in that containing in the said composition matter Magnesiumaluminumsilicate and volatile oil.
2. compositions according to claim 1, Magnesiumaluminumsilicate and volatile oil are 0.3: 1～10: 1 in proportion.
3. compositions according to claim 2, Magnesiumaluminumsilicate and volatile oil are 0.4: 1～5: 1 in proportion.
4. compositions according to claim 3, Magnesiumaluminumsilicate and volatile oil are 0.5: 1～2: 1 in proportion.
5. according to the described compositions of claim 1～4, wherein Magnesiumaluminumsilicate is natural Magnesiumaluminumsilicate.
6. according to the described compositions of claim 1～4, wherein Magnesiumaluminumsilicate is the synthetic silicic acid magnalium.
7. according to the described compositions of claim 1～6, wherein volatile oil is the grease of easy volatile oil at normal temperatures that from Chinese medicine, extracts, and it basic composition is aliphatic, aromatic series and terpenoid.
8. compositions according to claim 7; Volatile oil wherein is Oleum Ocimi Gratissimi, Oleum Anisi Stellati, patchouli oil, Oleum Cinnamomi, Oleum Viticis Negundo, Oleum Terebinthinae, Oleum Curcumae, Oleum Eucalypti, Oleum Rhododendri Daurici, Oleum menthae, Herba Houttuyniae volatile oil, Flos Lonicerae volatile oil, Rhizoma Chuanxiong volatile oil, oil of Rhizoma Zingiberis Recens, Radix Bupleuri volatile oil, limonene, Radix Oenotherae erythrosepalae oil, Folium perillae acutae oil, Fructus Forsythiae oil, Oleum Caryophylli, wintergreen oil, Folium Perillae oil, Radix Angelicae Sinensis oil, Rhizoma Atractylodis Macrocephalae oil, Fructus Amomi oil, oil of Rhizoma Zingiberis Recens, Oleum Bulbus Allii, Rhizoma Chuanxiong oil, Myrrha, Radix Angelicae Dahuricae oil, Rhizoma Acori Graminei oil, Rhizoma Atractylodis oil, Herba Moslae oil, Oleum Citri Reticulatae, Oleum lavandula angustifolia, Fructus Citri Limoniae oil, citronella oil, Oleum Menthae Rotundifoliae, Radix Aucklandiae oil, nutgrass galingale oil, chilli oil, Oleum Pelargonii Graveolentis, Oleum Hippophae, fruit of cubeb litsea tree oil, Oleum Terebinthinae, Fructus Citri oil, Lignum Dalbergiae Odoriferae oil, Oleum Ricini, Radix Et Rhizoma Nardostachyos oil, Flos Magnoliae oil, Oleum Asari, essential balm, Flos Chrysanthemi volatile oil, Resina Ferulae volatile oil.
9. according to the said compositions of claim 1～8, this combination is used to prepare tablet, capsule, granule, powder and other pharmaceutically acceptable dosage form pharmaceutically.
10. according to the said compositions of claim 1～8, this Combination application contains food, food additive and the health product of volatile oil in manufacturing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102356811A CN102335207A (en) | 2010-07-26 | 2010-07-26 | Composition containing magnesium aluminum silicate and volatile oil |
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| US6514505B2 (en) * | 2000-12-28 | 2003-02-04 | Paula Dorf | Cosmetic composition for adding fullness to the lips and surrounding area |
| CN1568711A (en) * | 2003-07-12 | 2005-01-26 | 郦安江 | Method for applying active constitutent of Bunge prickly ash to chemurgy products |
| CN101646419A (en) * | 2006-11-08 | 2010-02-10 | 诺瓦瓦克斯股份有限公司 | Method of preparing solid dosage forms of multi-phasic pharmaceutical compositions |
| CN101674813A (en) * | 2007-01-22 | 2010-03-17 | 诺瓦瓦克斯股份有限公司 | Multi-phasic pharmaceutical formulations of poorly water-soluble drugs for reduced fed/fasted variability and improved oral bioavailability |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514505B2 (en) * | 2000-12-28 | 2003-02-04 | Paula Dorf | Cosmetic composition for adding fullness to the lips and surrounding area |
| CN1568711A (en) * | 2003-07-12 | 2005-01-26 | 郦安江 | Method for applying active constitutent of Bunge prickly ash to chemurgy products |
| CN101646419A (en) * | 2006-11-08 | 2010-02-10 | 诺瓦瓦克斯股份有限公司 | Method of preparing solid dosage forms of multi-phasic pharmaceutical compositions |
| CN101674813A (en) * | 2007-01-22 | 2010-03-17 | 诺瓦瓦克斯股份有限公司 | Multi-phasic pharmaceutical formulations of poorly water-soluble drugs for reduced fed/fasted variability and improved oral bioavailability |
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Application publication date: 20120201 |