CN102327359A - Compound nifedipine ointment and application thereof - Google Patents
Compound nifedipine ointment and application thereof Download PDFInfo
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- CN102327359A CN102327359A CN201110234321A CN201110234321A CN102327359A CN 102327359 A CN102327359 A CN 102327359A CN 201110234321 A CN201110234321 A CN 201110234321A CN 201110234321 A CN201110234321 A CN 201110234321A CN 102327359 A CN102327359 A CN 102327359A
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Abstract
The invention discloses a compound nifedipine ointment and application thereof. The ointment is mainly prepared from the following raw materials in parts by weight according to the conventional preparation process: 5-25 parts of coptis root, 5-20 parts of rhizoma corydalis, 10-35 parts of astragalus, 5-25 parts of lucid ganoderma, 5-20 parts of safflower, 5-30 parts of red-rooted salvia root, 5-30 parts of dahurian angelica root, 5-25 parts of Chinese angelica, 5-20 parts of frankincense, 5-20 parts of myrrh, 5-25 parts of baikal skullcap root, 5-25 parts of amur corktree bark and 150-450 parts of vaseline. And a finished compound nifedipine ointment is obtained by adding 0.2-1.2 grams of nifedipine into every 100 grams of ointment. The ointment has a very ideal treating effect on anus pain after anus surgery, and particularly mixed hemorrhoid surgery.
Description
Technical field
The present invention relates to hemorrhoid postoperative proctalgia such as a kind of compound recipe nifedipine ointment and this Drug therapy podex postoperative, especially mixed hemorrhoid and promote the purposes of wound healing, belong to field of pharmaceutical technology.
Background technology
Hemorrhoid (hemorrhoid) are modal anal and intestinal diseases.Any age can fall ill, but with age growth, sickness rate increases.The supporting structure of anus pad, venous plexus and arterial anastomosis Zhi Fasheng pathologic change or displacement is internal hemorrhoid (internal hemorrhoid); Pathologic expansion or the thrombosis of pectinate line distally venae subcutaneae clump are external hemorrhoid (external hemorrhoid); Internal hemorrhoid is fused to mixed hemorrhoid (mixed hemorrhoid) mutually through the abundant venous plexus ramus anastomoticus and the external hemorrhoid of corresponding site.The method of conventional treatment hemorrhoid generally adopts the operative treatment of doctor trained in Western medicine, and the purpose of operative treatment is to extract blood stasis or make it thromboembolism or wither with mechanical means such as stitching bundle, though therapeutic effect is apparent in view; But postoperative pain is violent, wound healing time is long, not only can cause many complication such as difficult defecation, urine retention, can also produce a series of pathophysiological change; Make the patient nervous; Rapid breathing, heart rate is accelerated, hypertension; Serious caused cordis and cerebral accident directly has influence on surgical effect.Think that at present the principal element of bringing out the anorectal disease postoperative pain has: 1. local organization receives in various degree operation stimulation and damage; 2. postoperative wound surface exposes, and nerve receives extraneous chemical factors repetitious stimulation; 3. the contraction of postoperative sphincterismus property aggravates the pain.In these reasons, operation wound is the main cause of the early stage pain of postoperative, and sphincterismus is the main cause of postoperative constant pain, is again the inducement that aggravates the pain.Therefore how to research and develop a medicine that effectively slows down postoperative pain, accelerating wound healing, become the industry problem demanding prompt solution.
Summary of the invention
The objective of the invention is to, a kind of compound recipe nifedipine ointment and uses thereof is provided.The present invention can not only alleviate operation back anus wound pain effectively; Partial blood be can also improve and blood circulation promoting, accelerating wound healing supplied.
The object of the invention can be realized through following technical proposal: compound recipe nifedipine ointment; This ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier Rhizoma Coptidis 5-25 part, Rhizoma Corydalis 5-20 part, Radix Astragali 10-35 part, Ganoderma 5-25 part, Flos Carthami 5-20 part, Radix Salviae Miltiorrhizae 5-30 part, Radix Angelicae Dahuricae 5-30 part, Radix Angelicae Sinensis 5-25 part, Olibanum 5-20 part, Myrrha 5-20 part, Radix Scutellariae 5-25 part, Cortex Phellodendri 5-25 part and vaseline 150-450 part are processed ointment, the nifedipine by every 100g ointment adding 0.2-1.2g makes finished product again.
In the above-mentioned compound recipe nifedipine ointment; This ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier Rhizoma Coptidis 5-20 part, Rhizoma Corydalis 10-15 part, Radix Astragali 15-30 part, Ganoderma 10-20 part, Flos Carthami 5-15 part, Radix Salviae Miltiorrhizae 10-25 part, Radix Angelicae Dahuricae 10-25 part, Radix Angelicae Sinensis 10-20 part, Olibanum 10-15 part, Myrrha 10-15 part, Radix Scutellariae 5-20 part, Cortex Phellodendri 5-20 part and vaseline 200-400 part are processed ointment, the nifedipine by every 100g ointment adding 0.2-0.6g makes finished product again.
In the aforesaid compound recipe nifedipine ointment; This ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier Rhizoma Coptidis 20g, Rhizoma Corydalis 15g, Radix Astragali 30g, Ganoderma 10g, Flos Carthami 15g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Dahuricae 20g, Radix Angelicae Sinensis 15g, Olibanum 15g, Myrrha 15g, Radix Scutellariae 20g, Cortex Phellodendri 20g and vaseline 200g are processed ointment, add the 0.2g nifedipine by every 100g ointment again and make finished product.
The purposes of aforesaid compound recipe nifedipine ointment, this ointment are used to treat podex postoperative proctalgia and promote wound healing.
In the purposes of above-mentioned compound recipe nifedipine ointment, this ointment is used to treat hemorrhoid postoperative proctalgia and promotes wound healing.
In the purposes of aforesaid compound recipe nifedipine ointment, this ointment is used to treat mixed hemorrhoid postoperative proctalgia and promotes wound healing.
Compared with prior art, the present invention not only can effectively suppress sphincterismus can block superposition, ends its vicious cycle, alleviates the anus wound pain; And can shorten wound healing time, ease the pain.Nifedipine is a dihydropyridine type calcium antagonists in the component of the present invention, and the alternative transmembrane transport that suppresses calcium ion entering myocardial cell and smooth muscle cell is cardiology department's medicine commonly used.It can suppress the sarcoplasm that extracellular calcium ion gets into internal sphincter, reduces myofibrillar mechanical contraction, thereby has reduced the consumption of oxygen; And it also has anti-inflammatory activity, can suppress the release of chemical mediators such as histamine, reduces vagal irritability; To microcirculatory regulatory function and partial useful effect, can make the anal canal internal sphincter lax, reduce the anal canal venous pressure; Increase the blood perfusion of anal canal skin, thereby make pain relief and wound healing.The combination of other component of the present invention and proportioning thereof then is the result of applicant through clinical trial repeatedly, contrast, screening, summary; Effect with very ideal blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, putrefaction-removing granulation-promoting; Being used for the podex postoperative wound changes dressings; Curative effect is good, can shorten wound healing time, ease the pain.Therefore, one aspect of the present invention has flat lax sphincter, improves the effect that blood supplies, and reduces the vasoactive side effect on the other hand, has the effect that promotes wound healing simultaneously, and result of use is very desirable.
Clinical trial situation of the present invention:
1, select case:
35 examples are organized in treatment, male 16 examples, women 19 examples.27～75 years old age, average 48.42 ± 10.62 years old.The course of disease 4.9～46 years, average 9.48 ± 6.24 years.Wherein 7 examples merge the anal papilla tumor.
Horizon group 32 examples, male 17 examples, women 15 examples.28～75 years old age, average 50.62 ± 11.64 years old.The course of disease 5.0～42 years, average 9.22 ± 6.84 years.Wherein 4 examples merge the anal papilla tumor.
Matched group 31 examples, male 15 examples, women 16 examples.27～74 years old age, average 42.51 ± 11.23 years old.The course of disease 6.0～39 years, average 7.95 ± 6.90 years.Wherein 3 examples merge anal papilla tumor, 2 routine anal fissure, 1 routine injection of sclerosing agent history.
2, Therapeutic Method: the art treatment of pricking the hand in lumbar anesthesia, the outer stripping of mixed hemorrhoid row, postoperative was all used hemorrhage 1～2 day, antibiotic 1～3 day, anti symptom treatment when developing complications, the warm water demibain is to recovery from illness behind the defecation.Postoperative the 1st day applies ointment in operation crissum wound, and the treatment group applies the ointment of the present invention that weight portion raw material and proportioning by embodiment 4 make, and the Horizon group applies 0.2% nifedipine ointment, and matched group applies soft petroleum ointment; And all paint a wound 1～2 time/day, about ampoule 3g, with 2%PVP solution disinfection, cleaning wound surface.
3, observational technique: observe indexs such as the average pain index of patient, defecation pain index, wound healing time, wound surface are hemorrhage, edema wound, anus stool control mode ability, cardiovascular side effects (blood pressure, pulse, headache, dizziness etc.), the detection of anal canal dynamic variation, hospital stays.
Pain: adopt visual analogue scale (VAS) method, observe postoperative pain degree in 1 week, 0 is divided into painlessly, and 10 are divided into pain.The average of getting in its 1 week is average pain index; Record proctalgia index during defecation in 1 week is got its meansigma methods, is defecation pain index.
Hemorrhage: adopt the symptom scoring method to observe hemorrhage situation, 0 is divided into no hemorrhage or toilet paper band blood, and amount is less than 1ml; 1 is divided into and bleeds after an action of the bowels or solve congestion, and amount is less than 10ml; 2 are divided into amount of bleeding greater than 20ml.
Edema wound: edema appears in anus wound skin, and diameter surpasses 0.5cm, then is judged as edema.
Anus stool control mode ability drop: rare water is just controlled not good, the dirty trousers of feces, and having just anticipates promptly need separate, and can not control, even anal incontinence occur.
The anal canal dynamic variation detects: adopt U.S. Polygram anus to press the capable anus kinetic measurement of measuring instrument, detect index and comprise anal canal rest pressure, anal canal systolic pressure, preceding 1 day of Rhizoma Atractylodis Macrocephalae and postoperative detected in the 2nd day, the 4th day, the 7th day respectively, got the postoperative meansigma methods.
Cardiovascular side effects: cardiovascular relevant symptoms during the record patient medication, headache, dizzy, nervous, uncomfortable in chest, Blushing etc. are monitored patient's blood pressure, pulse, 3 times/day.
The statistical procedures enumeration data adopts x2 check or the accurate probability inspection of Fish, and measurement data adopts variance analysis, and P＜0.05 difference has statistical significance.
4, result of the test:
3 groups of case operation processs are smooth, situation such as massive hemorrhage and anesthetic accident in the no art.
The treatment group be lower than the Horizon group, but difference does not have statistical significance (P＞0.05) being lower than matched group (P＜0.05) aspect average pain index, the defecation pain index.3 groups of patient's bleeding symptoms, anus stool control mode ability do not have difference (P＞0.05).The matched group edema wound is specifically seen table 1 more than other 2 groups (P＜0.05).
Treatment is formed the face healing time and is shorter than other 2 groups (P＜0.05), and 3 groups of length of patient stay's differences do not have statistical significance (P＞0.05), specifically see table 2.
Anal canal rest pressure and systolic pressure difference do not have statistical significance (P＞0.05) before 3 groups of patient's arts; The postoperative anal canal rest pressure of treatment group and Horizon group is lower than matched group (P＜0.05); 3 groups of patient's anal canal systolic pressures do not have difference (P＞0.05), specifically see table 3.
Matched group does not have the cardiovascular relevant symptoms, and monitoring patient blood pressure, pulse do not have exception record.Treatment group and Horizon group respectively have 2 examples dizziness or headache, flushed face to occur, but monitoring blood pressure, pulse are obviously not unusual, do not give intervening and handle.
Pain index, hemorrhage, edema symptom comparison
behind 3 groups of corrective surgeries of table 1
Annotate: compare with the treatment group,
*P＜0.05.
3 groups of patient's wound healing times of table 2 and hospital stays are observed table
Annotate: compare with the treatment group,
*P＜0.05.
3 groups of patient's postoperatives of table 3 anal canal dynamic variation detects observes table
Annotate: compare with the treatment group,
*P＜0.05.
Can draw from above-mentioned clinical test results,, apply the present invention behind surgical wound surface, in pain index, hemorrhage, edema symptom compared to 0.2% nifedipine ointment and soft petroleum ointment commonly used; Aspects such as patient's wound healing time and patient's postoperative anal canal dynamic variation all have bigger advantage, have very ideal therapeutic effect.
The specific embodiment
Embodiment 1: compound recipe nifedipine ointment; This ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier 25 parts of Rhizoma Coptidis, 20 parts of Rhizoma Corydalis, 10 parts of the Radixs Astragali, 5 parts of Ganodermas, 5 parts on Flos Carthami, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 10 parts of Olibanums, 10 parts of Myrrhas, 25 parts of Radix Scutellariaes, 25 parts of Cortex Phellodendris, vaseline are processed ointment for 450 parts, add the 1g nifedipine by every 100g ointment again and make finished product; This ointment also comprise conventional adjuvant or the excipient of processing ointment.This ointment is used for the anus postoperative, characteristics are to be used for resuming treatment of hemorrhoid postoperatives such as mixed hemorrhoid, can not only slow down the postoperative proctalgia effectively, can also effectively promote wound healing.
The method for using of this ointment: postoperative applied ointment on the 1st day in operation crissum wound, paints a wound 1～2 time/day, and about ampoule 3g, and with 2%PVP solution disinfection, cleaning wound surface.
Embodiment 2: compound recipe nifedipine ointment; This ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier 5 parts of Rhizoma Coptidis, 20 parts of Rhizoma Corydalis, 10 parts of the Radixs Astragali, 25 parts of Ganodermas, 20 parts on Flos Carthami, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 20 parts of Olibanums, 20 parts of Myrrhas, 10 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, vaseline are processed ointment for 200 parts, add the 0.8g nifedipine by every 100g ointment again and make finished product; This ointment also comprise conventional adjuvant or the excipient of processing ointment.This ointment is used for the anus postoperative, characteristics are to be used for resuming treatment of hemorrhoid postoperatives such as mixed hemorrhoid, can not only slow down the postoperative proctalgia effectively, can also effectively promote wound healing.
The method for using of this ointment: postoperative applied ointment on the 1st day in operation crissum wound, paints a wound 1～2 time/day, and about ampoule 3g, and with 2%PVP solution disinfection, cleaning wound surface.
Embodiment 3: compound recipe nifedipine ointment; This ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier 5 parts of Rhizoma Coptidis, 15 parts of Rhizoma Corydalis, 20 parts of the Radixs Astragali, 10 parts of Ganodermas, 5 parts on Flos Carthami, 25 parts of Radix Salviae Miltiorrhizaes, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Radix Angelicae Sinensis, 15 parts of Olibanums, 15 parts of Myrrhas, 20 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, vaseline are processed ointment for 350 parts, add the 0.6g nifedipine by every 100g ointment again and make finished product; This ointment also comprise conventional adjuvant or the excipient of processing ointment.This ointment is used for the anus postoperative, characteristics are to be used for resuming treatment of hemorrhoid postoperatives such as mixed hemorrhoid, can not only slow down the postoperative proctalgia effectively, can also effectively promote wound healing.
The method for using of this ointment: postoperative applied ointment on the 1st day in operation crissum wound, paints a wound 1～2 time/day, and about ampoule 3g, and with 2%PVP solution disinfection, cleaning wound surface.
Embodiment 4: compound recipe nifedipine ointment; This ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier Rhizoma Coptidis 20g, Rhizoma Corydalis 15g, Radix Astragali 30g, Ganoderma 10g, Flos Carthami 15g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Dahuricae 20g, Radix Angelicae Sinensis 15g, Olibanum 15g, Myrrha 15g, Radix Scutellariae 20g, Cortex Phellodendri 20g and vaseline 200g are processed ointment, add the 0.2g nifedipine by every 100g ointment again and make finished product; This ointment also comprise conventional adjuvant or the excipient of processing ointment.This ointment is used for the anus postoperative, characteristics are to be used for resuming treatment of hemorrhoid postoperatives such as mixed hemorrhoid, can not only slow down the postoperative proctalgia effectively, can also effectively promote wound healing.
The method for using of this ointment: postoperative applied ointment on the 1st day in operation crissum wound, paints a wound 1～2 time/day, and about ampoule 3g, and with 2%PVP solution disinfection, cleaning wound surface.
Claims (6)
1. compound recipe nifedipine ointment; It is characterized in that: this ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier Rhizoma Coptidis 5-25 part, Rhizoma Corydalis 5-20 part, Radix Astragali 10-35 part, Ganoderma 5-25 part, Flos Carthami 5-20 part, Radix Salviae Miltiorrhizae 5-30 part, Radix Angelicae Dahuricae 5-30 part, Radix Angelicae Sinensis 5-25 part, Olibanum 5-20 part, Myrrha 5-20 part, Radix Scutellariae 5-25 part, Cortex Phellodendri 5-25 part and vaseline 150-450 part are processed ointment, the nifedipine by every 100g ointment adding 0.2-1.2g makes finished product again.
2. compound recipe nifedipine ointment according to claim 1; It is characterized in that: this ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier Rhizoma Coptidis 5-20 part, Rhizoma Corydalis 10-15 part, Radix Astragali 15-30 part, Ganoderma 10-20 part, Flos Carthami 5-15 part, Radix Salviae Miltiorrhizae 10-25 part, Radix Angelicae Dahuricae 10-25 part, Radix Angelicae Sinensis 10-20 part, Olibanum 10-15 part, Myrrha 10-15 part, Radix Scutellariae 5-20 part, Cortex Phellodendri 5-20 part and vaseline 200-400 part are processed ointment, the nifedipine by every 100g ointment adding 0.2-0.6g makes finished product again.
3. compound recipe nifedipine ointment according to claim 2; It is characterized in that: this ointment mainly is to be processed according to conventional preparation technology by the raw material of following weight portion: earlier Rhizoma Coptidis 20g, Rhizoma Corydalis 15g, Radix Astragali 30g, Ganoderma 10g, Flos Carthami 15g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Dahuricae 20g, Radix Angelicae Sinensis 15g, Olibanum 15g, Myrrha 15g, Radix Scutellariae 20g, Cortex Phellodendri 20g and vaseline 200g are processed ointment, add the 0.2g nifedipine by every 100g ointment again and make finished product.
4. according to the purposes of each described compound recipe nifedipine ointment of claim 1 to 3, it is characterized in that this ointment is used to treat podex postoperative proctalgia and promotes wound healing.
5. the purposes of compound recipe nifedipine ointment according to claim 4 is characterized in that, this ointment is used to treat hemorrhoid postoperative proctalgia and promotes wound healing.
6. the purposes of compound recipe nifedipine ointment according to claim 5 is characterized in that, this ointment is used to treat mixed hemorrhoid postoperative proctalgia and promotes wound healing.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735928A (en) * | 2014-01-02 | 2014-04-23 | 许伟 | Chinese medicinal mixture for treating perianal abscess |
| CN112691104A (en) * | 2021-02-04 | 2021-04-23 | 刘泽陆 | Medicine for treating hemorrhoids and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1981798A (en) * | 2005-12-12 | 2007-06-20 | 谭宝霞 | Multi-purpose shenji plaster |
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- 2011-08-16 CN CN 201110234321 patent/CN102327359B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1981798A (en) * | 2005-12-12 | 2007-06-20 | 谭宝霞 | Multi-purpose shenji plaster |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735928A (en) * | 2014-01-02 | 2014-04-23 | 许伟 | Chinese medicinal mixture for treating perianal abscess |
| CN112691104A (en) * | 2021-02-04 | 2021-04-23 | 刘泽陆 | Medicine for treating hemorrhoids and preparation method thereof |
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