CN102319059A - Near-infrared fluorescence imaging surgery guide device and application thereof - Google Patents
Near-infrared fluorescence imaging surgery guide device and application thereof Download PDFInfo
- Publication number
- CN102319059A CN102319059A CN201110332712A CN201110332712A CN102319059A CN 102319059 A CN102319059 A CN 102319059A CN 201110332712 A CN201110332712 A CN 201110332712A CN 201110332712 A CN201110332712 A CN 201110332712A CN 102319059 A CN102319059 A CN 102319059A
- Authority
- CN
- China
- Prior art keywords
- infrared
- light
- guiding device
- video camera
- operation guiding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Laser Surgery Devices (AREA)
Abstract
The invention relates to a near-infrared fluorescence imaging surgery guide device and an application thereof. The device comprises a near-infrared laser light source, a light collection optical system, a visual light filter, a near-infrared light filter, a color video camera, a near-infrared video camera and a terminal display. The device can conveniently perform position guide and morphic display functions in the process of a lymph excision or inactivation surgery, and meanwhile can be used for analyzing and evaluating the effect of the lymph excision or inactivation surgery. The device is favorable to improving surgery efficiency and accuracy and accumulating surgery treatment experience.
Description
Technical field
The present invention relates to the clinical operation guiding device and the application thereof of the imaging of a kind of near-infrared fluorescent, specifically, the present invention relates to a kind of device and the application thereof that the position is guided carried out in excision such as lymph or deactivation position.
Background technology
Come the method for labelling biomolecule in the biomedical research field, successfully to use the several years with radioactive tracer and fluorescent dye; But in the body clinical medicine imaging field of reality, the application of fluorescent probe in clinical research but is confined to the inspection of external dyeing tissue slice mostly.Up to the later stage eighties 20th century, some researcheres are attempted the fluorescent dye agent as a comparison of injection of exogenous in organism, through Noninvasive or in the optical measurement means of peeping, in lesion detection, distinguish morbid state and normal structure.In recent years, obtained great success in the method for carrying out in the tumor imaging in vivo using fluorescence indicator with near-infrared as exogenous contrast medium.
In the prior art; When carrying out the inadvertent closure of live body lymph (human body or animal body); Surgical staff is injected fluorescent contrast agent through regular meeting in blood, contrast agent is absorbed by lymph in the blood circulation process, after after a while, can discharge along with the circulation of blood again simultaneously.Contrast agent can send the near infrared light with the near infrared light different-waveband that shines when receiving the near infrared ray irradiation; Then through gathering the superelevation sensitivity camera of near infrared light; Observe with monitor; With the position of correct grasp lymph body, correctly carry out the resection operation of lymph with the guiding surgical staff.
Shown in Figure 1 is carrying out lymph position of sending fluorescence and the device that form is observed as the assisted surgery personnel of having emerged at present.This device comprises near-infrared laser luminous source, video camera, optical filter, display.Near infrared light is behind the lymph body that has absorbed fluorescent contrast agent; The fluorescent contrast agent excitation-emission has gone out the near infrared light different with the irradiates light wave band; Get access to the near infrared light that fluorescent contrast agent is launched through optical filter; The near infrared light image that obtains through camera acquisition then shows that through display the near-infrared image that camera acquisition arrives supplies surgical staff to observe.But there is following shortcoming in said device:
(1), this device only can be observed and show the area image of the blood that contains fluorescent contrast agent and can not show the image that does not excite the position that does not contain fluorescent contrast agent blood.Can not see the situation of the operative region of the integral body that comprises the lymph body like this with regard to causing surgical staff can only see the lymph body situation of irradiated site; If watch the overall condition in whole surgery zone; Just need close the LASER Light Source of irradiation, but can't see the position and the form of hoping the excision position so again, surgical staff needs repeatedly at the irradiation near infrared light and closes between the near infrared light to switch repeatedly for this reason; Use very inconvenience, cause the puzzlement in operation process.
(2), this device provides through display direct observation operative region and has absorbed the lymph body means of fluorescent contrast agent; But the size that can not excise front and back to position and form, the operative region endolymph body of lymph body and form etc. are carried out quantitative record and analysis; Evaluation between resection operation and final therapeutic effect can not quantitatively be provided; Be unfavorable for the surgical staff summing up experience, exchange each other, improve treatment level.
Summary of the invention
In order to solve existing above-mentioned technical problem in the prior art; The invention provides a kind of near-infrared fluorescent radiography operation guiding device; Device of the present invention can be realized carrying out the function that location guide and form show easily in the process that the lymph body excises or deactivation is performed the operation; Also can be used in simultaneously assay is carried out in lymph excision or deactivation surgical effect.Device of the present invention has very big help for raising operation efficient, accuracy, accumulation experience of surgical.
First aspect of the present invention relates to a kind of near-infrared fluorescent radiography operation guiding device, and comprising: near-infrared laser luminous source, light are collected optical system, visible light light filter, near-infrared light filter, color video camera, near-infrared video camera and terminal display; It is characterized in that said near-infrared laser luminous source is used to shine the lymph body of injecting indocyanine green ICG, excites to make it send near-infrared fluorescent; Said light is collected optical system and is comprised light collector and beam splitter; Blood was stimulated and other shine the light of lymph body back reflection under emitted fluorescence and the surgical environments when said light collector was used to collect excitation source and shines the lymph body that has absorbed ICG, and the light that said beam splitter is collected light collector is divided into the identical light of two-way; Said visible light light filter filters the visible light that obtains visible wavelength range; Said near-infrared light filter filters the fluorescence of the near-infrared wavelength that obtains near infrared wavelength region; Said color video camera reception visible light light filter filters the visible light that obtains and obtains near-infrared image or video; Said near-infrared video camera reception near-infrared light filter filters the fluorescence that obtains and obtains visible images or video.
In this near-infrared fluorescent radiography operation guiding device, also comprise video capture card and analytical system.This video capture card is used for image or video signal from video camera are converted into the digital signal that can carry out stored digital and processing; This analytical system can realize the digital signal of video capture card collection is carried out recording and multiple morphological parameters analysis, calculating and the report that is used for clinical and research and teaching of the storage of various ways, multiple form.
In this near-infrared fluorescent radiography operation guiding device, said terminal display is used for direct near-infrared image and the visible images that shows from camera acquisition, and two kinds of images can show respectively, show side by side that simultaneously perhaps stack shows.
In this near-infrared fluorescent radiography operation guiding device; Said terminal display is used to show the digital signal of storing or recording through analytical system; Perhaps directly show near-infrared image and visible images from camera acquisition, two kinds of images can show respectively, show side by side that simultaneously perhaps stack shows.
In this near-infrared fluorescent radiography operation guiding device, described near-infrared laser luminous source is the near-infrared luminous source of fixed wave length or the near-infrared laser luminous source of wavelength-tunable joint.Preferably, the wavelength of said near-infrared laser luminous source is 805nm.
In this near-infrared fluorescent radiography operation guiding device, the visible light that said visible light light filter permission wave-length coverage is 400-700nm passes through; The infrared ray that said near-infrared light filter permission wave-length coverage is 820-850nm passes through.
In this near-infrared fluorescent radiography operation guiding device, said video capture card is integrated in the computer of analytical system or is integrated in the video camera.
Second aspect of the present invention relates to the application of above-mentioned near-infrared fluorescent radiography operation guiding device, is used for excision or deactivation operation process, and location guide and effect assessment are carried out in excision such as lymph body or deactivation position.
The operating principle of near-infrared fluorescent radiography operation guiding device of the present invention: described near-infrared laser luminous source is the near-infrared luminous source of fixed wave length or the near-infrared laser luminous source of wavelength-tunable joint; Blood was stimulated and other shine the reflected light behind the lymph body under emitted fluorescence and the surgical environments when said light collector was used to collect excitation source and shines the lymph body that has absorbed ICG; The light that said beam splitter is collected light collector is divided into the identical light of two-way; The visible light that said visible light light filter permission wave-length coverage is 400-700nm passes through; The infrared ray that said near-infrared light filter permission wave-length coverage is 820-850nm passes through; See through two optical filters with different filtering characteristics then respectively and carry out the collection of optical signal by video camera; Obtain under the visible light respectively and the video image under the near infrared light; Two kinds of video images that obtain can directly in display device, distinguish or stack shows; Supply surgical staff intuitively to observe, carry out digitized through the data collection and analysis system simultaneously, carry out respectively on computers or synergetic demonstration, record and carry out the analysis and the report of different morphological data.
Compared with prior art, the present invention has following beneficial technical effects:
(1) adopted the two-way video camera to gather visible light coloured image and near-infrared fluorescent image simultaneously from operative region; And directly fluoroscopic image being handled the back is added on the coloured image of visible light with specific color; Especially we have broken through usual thinking and have adopted the beam splitter that light is divided into the identical light of two-way, rather than light is divided into the beam splitter of near infrared light and visible light in advance; Thereby can guarantee that visible light coloured image and near-infrared fluorescent image can directly superpose and can not produce position deviation, also not have the irradiation blind area; And if according to common operational approach; Use is divided into light the beam splitter of near infrared light and visible light in advance; Visible light coloured image that obtains and near-infrared fluorescent image can produce position deviation when directly superposeing, thereby bring significant error for follow-up operation; Also can there be the blind area in the image that obtains that superposes in addition.
(2) we find through a large amount of simulation tests; Adopting the wavelength of near-infrared laser luminous source is the fluorescence of 805nm; Can be so that absorbing the wavelength overwhelming majority of the near-infrared fluorescent light that the lymph body of ICG excites concentrate in the scope of 825-840nm nanometer, thus utilize wave-length coverage can write down the positional information of the lymph body that absorbs ICG to greatest extent for the near-infrared light filter of 820-850nm; The accuracy and the resolution of the image that obtains have been improved.
(3) adopt device of the present invention to make surgical staff can see simultaneously that the integral body of field of operation and lymph body wherein get situation, farthest adapt to watching and thinking habit of surgical staff, promote operation efficient and correctness.But also the size that can excise front and back to position and form, the operative region endolymph body of lymph body and form etc. are carried out quantitative record and analysis; Evaluation between resection operation and final therapeutic effect quantitatively is provided; Be unfavorable for the surgical staff summing up experience, exchange each other, improve treatment level.
Description of drawings
Fig. 1: near-infrared fluorescent operation guiding device block chart of the prior art;
Fig. 2: the sketch map of the near-infrared fluorescent operation guiding device of one embodiment of the invention;
Fig. 3: the near infrared light absorbance of the indocyanine green ICG of use, fluorescent radiation rate and wavelength curve;
Fig. 4: the wavelength and the transmittance curve of the near-infrared filter lens that one embodiment of the invention is used;
Fig. 5: the wavelength and the transmittance curve of the visible light filter lens that one embodiment of the invention is used.
The implication of Reference numeral representative is respectively among the figure: 0-comprises the lymph body of injecting ICG blood; 1-near-infrared laser light source; 2-visible illumination light source; 3-light is collected optical system; The 4-beam splitter; 5-visible light light filter; 6-near-infrared light filter; The 7-color video camera; 8-near-infrared video camera; The 9-terminal display; The 10-analytical system.
The specific embodiment
To combine accompanying drawing and concrete embodiment that technical scheme of the present invention is described in detail below, but accompanying drawing and specific embodiment be not as the qualification to patent of the present invention.
As shown in Figure 2; The present invention proposes a kind of excision or deactivation operation process of being used for; The near-infrared fluorescent radiography operation guiding device that the position is guided and effect is estimated is carried out at excision positions such as lymph; It comprises a near-infrared laser luminous source, can launch the near-infrared laser that wavelength is 805nm, 1500mW; Near-infrared laser shines and has absorbed the surgical object surface of containing indocyanine green ICG blood, and ICG is stimulated and penetrates the near infrared light of 835nm.The radiation of visible light that exists in the surgical environments produces reflected light and scattered light behind the operation body; The light that has mixed 805nm near infrared light, 835nm near infrared light, visible light is divided into the identical light of two bundles through spectroscope and arrives visible light light filter and near-infrared light filter; The transmitance of optical filter and wavelength curve are like Fig. 4, shown in 5; It is that the near infrared light of 20nm wave band passes through for the 835nm bandwidth that near infrared filter allows centre wavelength, and it is that the visible light of 400nm-700nm passes through that visible filter allows wave-length coverage; Get into near-infrared video camera and color video camera respectively through the filtering visible light of having removed the near infrared light of the following wavelength of 820nm (805nm and visible light) and only having comprised the 400-700nm wave band of optical filter; Video camera is connected to terminal display after optical signal is converted into video electrical signal, is connected to the video signal input terminal of analytical system simultaneously, supplies its built-in video capture card mimic video signal to be converted into the view data of numeral.Method through software realize to digitized view data store, record, calculate, analyze, processing such as report.
The model of near infrared laser is: DH-NIR805,1500mW, 805nm; Spectroscope customizes to optical coating company separately according to the dimensional requirement of industrial design; Near-infrared and color video camera CCD all adopt SONY low-light (level) ICX639AK chip; Monitor is general LCD TV; Image pick-up card model in the data collection and analysis system is DH321.
Through adopting this experimental program; Can see simultaneously during operation on the true colored operation volume image that is added to needs the lymph body of excision to get vision-mix; For confirming that accurate position and the form of lymph body on the operation body has effect intuitively; Can guide surgical staff high efficiency, completion excision or deactivation operation exactly easily, and can write down perioperatively and operation process, and accomplish the evaluation analysis of surgical effect quantitatively.
The above; Be merely the preferred embodiments of the present invention; Can not be interpreted as with this and limit scope of the present invention, the embodiment of all distortion of in claims of the present invention require the scope of protection, being made that is equal to and change is all in the present invention's scope required for protection.
Claims (10)
1. a near-infrared fluorescent radiography operation guiding device comprises: near-infrared laser luminous source, light collection optical system, visible light light filter, near-infrared light filter, color video camera, near-infrared video camera and terminal display; It is characterized in that said near-infrared laser luminous source is used to shine the lymph body of injecting indocyanine green, excites to make it send near-infrared fluorescent; Said light is collected optical system and is comprised light collector and beam splitter; Blood was stimulated and other shine the light of lymph body back reflection under emitted fluorescence and the surgical environments when said light collector was used to collect excitation source and shines the lymph body that has absorbed indocyanine green, and the light that said beam splitter is collected light collector is divided into the identical light of two-way; Said visible light light filter filters the visible light that obtains visible wavelength range; Said near-infrared light filter filters the fluorescence of the near-infrared wavelength that obtains near infrared wavelength region; Said color video camera reception visible light light filter filters the visible light that obtains and obtains near-infrared image or video; Said near-infrared video camera reception near-infrared light filter filters the fluorescence that obtains and obtains visible images or video.
2. near-infrared fluorescent radiography operation guiding device according to claim 1 is characterized in that also comprising video capture card and analytical system; This video capture card is used for image or video signal from video camera are converted into the digital signal that can carry out stored digital and processing; This analytical system can realize the digital signal of video capture card collection is carried out recording and multiple morphological parameters analysis, calculating and the report that is used for clinical and research and teaching of the storage of various ways, multiple form.
3. near-infrared fluorescent radiography operation guiding device according to claim 1; It is characterized in that said terminal display is used for direct near-infrared image and the visible images that shows from camera acquisition, two kinds of images can show respectively, show side by side that simultaneously perhaps stack shows.
4. near-infrared fluorescent radiography operation guiding device according to claim 2 is characterized in that said terminal display is used to show the digital signal of storing or recording through analytical system; Perhaps directly show near-infrared image and visible images from camera acquisition, two kinds of images can show respectively, show side by side that simultaneously perhaps stack shows.
5. according to each described near-infrared fluorescent radiography operation guiding device of claim 1-4, it is characterized in that described near-infrared laser luminous source is the near-infrared luminous source of fixed wave length or the near-infrared laser luminous source of wavelength-tunable joint.
6. near-infrared fluorescent radiography operation guiding device according to claim 5, the wavelength that it is characterized in that said near-infrared laser luminous source is 805nm.
7. near-infrared fluorescent radiography operation guiding device according to claim 6 is characterized in that the infrared ray that said near-infrared light filter permission wave-length coverage is 820-850nm passes through.
8. near-infrared fluorescent radiography operation guiding device according to claim 7 is characterized in that the visible light that said visible light light filter permission wave-length coverage is 400-700nm passes through.
9. according to claim 2 or 4 described near-infrared fluorescent radiographies operation guiding devices, it is characterized in that said video capture card is integrated in the computer of analytical system or is integrated in color video camera and the near-infrared video camera.
10. according to the application of each described near-infrared fluorescent radiography operation guiding device of claim 1-9, it is characterized in that being used for excision or deactivation operation process, location guide and effect assessment are carried out in excision such as lymph body or deactivation position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110332712 CN102319059B (en) | 2011-10-28 | 2011-10-28 | Near-infrared fluorescence imaging surgery guide device and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110332712 CN102319059B (en) | 2011-10-28 | 2011-10-28 | Near-infrared fluorescence imaging surgery guide device and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102319059A true CN102319059A (en) | 2012-01-18 |
| CN102319059B CN102319059B (en) | 2013-03-27 |
Family
ID=45446996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110332712 Active CN102319059B (en) | 2011-10-28 | 2011-10-28 | Near-infrared fluorescence imaging surgery guide device and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102319059B (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871651A (en) * | 2012-10-26 | 2013-01-16 | 哈尔滨海鸿基业科技发展有限公司 | Near infrared lymphatic detector |
| WO2014044220A1 (en) * | 2012-09-21 | 2014-03-27 | Wang Hao | Measurement mode selection device and measurement mode selection method |
| CN104364606A (en) * | 2012-05-24 | 2015-02-18 | 三菱电机工程技术株式会社 | Image capture device and image capture method |
| CN105962891A (en) * | 2016-04-21 | 2016-09-28 | 莱博泰克（大连）科技有限公司 | Contact-type excitation light source used for fluorescence imaging detecting system |
| CN106236265A (en) * | 2016-08-31 | 2016-12-21 | 北京数字精准医疗科技有限公司 | A kind of hand-held molecular image guider and system |
| WO2017117710A1 (en) * | 2016-01-05 | 2017-07-13 | 秀传医疗社团法人秀传纪念医院 | Imaging system and method for endoscopy |
| CN106943193A (en) * | 2017-04-27 | 2017-07-14 | 华中科技大学 | Common location operation guiding system and camera head |
| CN108209878A (en) * | 2018-03-06 | 2018-06-29 | 南京生命源医药实业有限公司 | Visualization system and method |
| CN109171661A (en) * | 2018-10-10 | 2019-01-11 | 南京诺源医疗器械有限公司 | Fluoroscopic visualization checks system excitation light source |
| CN109363768A (en) * | 2018-10-10 | 2019-02-22 | 南京诺源医疗器械有限公司 | 785nm wavelength light source near-infrared fluorescence imaging surgery guides system |
| TWI667994B (en) * | 2017-12-29 | 2019-08-11 | 高雄榮民總醫院 | Imaging device and displaying method by using indocyanine green |
| CN112188872A (en) * | 2018-05-24 | 2021-01-05 | 学校法人庆应义塾 | Surgical viewing system |
| CN112235595A (en) * | 2020-11-04 | 2021-01-15 | 无锡蓝软智能医疗科技有限公司 | Operation scene dynamic presenting method, system and medium based on mixed reality technology |
| WO2022033151A1 (en) * | 2020-08-10 | 2022-02-17 | 嘉兴市第二医院 | Fluorescent camera based on indocyanine green, and use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101574529A (en) * | 2009-06-04 | 2009-11-11 | 中国人民解放军第三军医大学 | Application of near infrared fluorescent chemical in lymphaden imaging and angiogram |
| CN201664343U (en) * | 2008-11-11 | 2010-12-08 | 深圳市莫廷影像技术有限公司 | Operating microscope system with angiographic function |
-
2011
- 2011-10-28 CN CN 201110332712 patent/CN102319059B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201664343U (en) * | 2008-11-11 | 2010-12-08 | 深圳市莫廷影像技术有限公司 | Operating microscope system with angiographic function |
| CN101574529A (en) * | 2009-06-04 | 2009-11-11 | 中国人民解放军第三军医大学 | Application of near infrared fluorescent chemical in lymphaden imaging and angiogram |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104364606A (en) * | 2012-05-24 | 2015-02-18 | 三菱电机工程技术株式会社 | Image capture device and image capture method |
| EP2857793B1 (en) * | 2012-05-24 | 2019-12-11 | Mitsubishi Electric Engineering Company Limited | Image capture device and image capture method |
| WO2014044220A1 (en) * | 2012-09-21 | 2014-03-27 | Wang Hao | Measurement mode selection device and measurement mode selection method |
| CN102871651A (en) * | 2012-10-26 | 2013-01-16 | 哈尔滨海鸿基业科技发展有限公司 | Near infrared lymphatic detector |
| WO2017117710A1 (en) * | 2016-01-05 | 2017-07-13 | 秀传医疗社团法人秀传纪念医院 | Imaging system and method for endoscopy |
| CN105962891B (en) * | 2016-04-21 | 2018-07-24 | 莱博泰克（大连）科技有限公司 | A kind of contact excitation light source of fluorescence imaging detecting system |
| CN105962891A (en) * | 2016-04-21 | 2016-09-28 | 莱博泰克（大连）科技有限公司 | Contact-type excitation light source used for fluorescence imaging detecting system |
| CN106236265A (en) * | 2016-08-31 | 2016-12-21 | 北京数字精准医疗科技有限公司 | A kind of hand-held molecular image guider and system |
| CN106943193A (en) * | 2017-04-27 | 2017-07-14 | 华中科技大学 | Common location operation guiding system and camera head |
| TWI667994B (en) * | 2017-12-29 | 2019-08-11 | 高雄榮民總醫院 | Imaging device and displaying method by using indocyanine green |
| CN108209878A (en) * | 2018-03-06 | 2018-06-29 | 南京生命源医药实业有限公司 | Visualization system and method |
| CN112188872A (en) * | 2018-05-24 | 2021-01-05 | 学校法人庆应义塾 | Surgical viewing system |
| CN109171661A (en) * | 2018-10-10 | 2019-01-11 | 南京诺源医疗器械有限公司 | Fluoroscopic visualization checks system excitation light source |
| CN109363768A (en) * | 2018-10-10 | 2019-02-22 | 南京诺源医疗器械有限公司 | 785nm wavelength light source near-infrared fluorescence imaging surgery guides system |
| WO2022033151A1 (en) * | 2020-08-10 | 2022-02-17 | 嘉兴市第二医院 | Fluorescent camera based on indocyanine green, and use thereof |
| CN112235595A (en) * | 2020-11-04 | 2021-01-15 | 无锡蓝软智能医疗科技有限公司 | Operation scene dynamic presenting method, system and medium based on mixed reality technology |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102319059B (en) | 2013-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102319059B (en) | Near-infrared fluorescence imaging surgery guide device and application thereof | |
| US10258275B2 (en) | Methods and systems for intra-operatively providing anatomical guidance in surgery | |
| CN102770071B (en) | System and method for providing real-time anatomical guidance in a diagnostic or therapeutic procedure | |
| JP6550532B2 (en) | Real-time brain tumor detection device and brain tumor surgery device | |
| CN102892348B (en) | The method and apparatus of multispectral photon imaging | |
| US7515952B2 (en) | System for characterization and mapping of tissue lesions | |
| US9566030B2 (en) | Optical system for detection and characterization of abnormal tissue and cells | |
| CN101433458A (en) | Multimodal imaging system for tissue imaging | |
| US9833145B2 (en) | Method for simultaneously detecting fluorescence and raman signals for multiple fluorescence and raman signal targets, and medical imaging device for simultaneously detecting multiple targets using the method | |
| US10674918B2 (en) | Near-infrared (NIR) optical scanner | |
| CN106580264A (en) | Terahertz wave attenuation total reflection imaging-based cerebral trauma tissue detection device | |
| CN201750891U (en) | Near-infrared fluorescence imaging clinical diagnosing system | |
| CN103163111A (en) | Early stage cervical carcinoma detection system integrating fluorescent mesoscope imaging and optical coherence tomography (OCT) | |
| US11050951B2 (en) | Guidance system for a near-infrared fluorescein angiography operation with a 785nm continuous wavelength light source | |
| CN103462645A (en) | Forward-looking optic-acoustic endoscope | |
| CN105996999A (en) | Method and system for measuring depth resolution attenuation coefficient of sample based on OCT | |
| WO2021212834A1 (en) | Fluorescein angiography testing system based on 785 nm wavelength light source | |
| CN104067313A (en) | Imaging apparatus | |
| CN108523849A (en) | Based on autofluorescence technology and the classification of the thyroid gland neck tissue of optical coherence tomography and identifying system and method | |
| JP2016508768A (en) | Optical device for use with a medical imaging device | |
| CN202313279U (en) | Guide device of near-infrared fluorescence angiography surgery | |
| CN206852585U (en) | A kind of cerebral trauma tissue detection device for the total reflection imaging that decayed based on THz wave | |
| KR101166556B1 (en) | Fluorescence sensing probe and fluorescence sensing method using the same | |
| CN110755738A (en) | Navigation method and system for optical image operation seed source implantation | |
| US20240041388A1 (en) | System for facilitating differentiation between parathyroid tissue and thyroid tissue and applications of same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |