CN102309536A - Ointment for treating frostbite and rahagades and preparation method of ointment - Google Patents
Ointment for treating frostbite and rahagades and preparation method of ointment Download PDFInfo
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- CN102309536A CN102309536A CN2010102203430A CN201010220343A CN102309536A CN 102309536 A CN102309536 A CN 102309536A CN 2010102203430 A CN2010102203430 A CN 2010102203430A CN 201010220343 A CN201010220343 A CN 201010220343A CN 102309536 A CN102309536 A CN 102309536A
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- semen vaccariae
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- 239000002674 ointment Substances 0.000 title claims abstract description 48
- 208000001034 Frostbite Diseases 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title abstract description 16
- 241000222336 Ganoderma Species 0.000 claims abstract description 59
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 43
- 239000012071 phase Substances 0.000 claims abstract description 31
- 239000011780 sodium chloride Substances 0.000 claims abstract description 21
- 239000008346 aqueous phase Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 68
- 210000000582 semen Anatomy 0.000 claims description 41
- 238000010438 heat treatment Methods 0.000 claims description 32
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 28
- 239000000284 extract Substances 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 19
- 239000002994 raw material Substances 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 230000006837 decompression Effects 0.000 claims description 16
- 238000004064 recycling Methods 0.000 claims description 16
- 238000010992 reflux Methods 0.000 claims description 16
- 235000021355 Stearic acid Nutrition 0.000 claims description 14
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 14
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 14
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 14
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 14
- 229940057995 liquid paraffin Drugs 0.000 claims description 14
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 14
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 14
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 14
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 14
- 239000008117 stearic acid Substances 0.000 claims description 14
- 229940099259 vaseline Drugs 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 238000001816 cooling Methods 0.000 claims description 9
- 238000002481 ethanol extraction Methods 0.000 claims description 8
- 239000000469 ethanolic extract Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 238000012360 testing method Methods 0.000 abstract description 13
- 239000003814 drug Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 4
- 238000002474 experimental method Methods 0.000 abstract description 2
- 238000011835 investigation Methods 0.000 abstract description 2
- 230000002110 toxicologic effect Effects 0.000 abstract description 2
- 231100000027 toxicology Toxicity 0.000 abstract description 2
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 208000009084 Cold Injury Diseases 0.000 description 31
- 230000002595 cold damage Effects 0.000 description 31
- 239000006071 cream Substances 0.000 description 22
- 150000001875 compounds Chemical class 0.000 description 9
- 241000283973 Oryctolagus cuniculus Species 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 238000007710 freezing Methods 0.000 description 5
- 230000008014 freezing Effects 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- 230000002528 anti-freeze Effects 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 238000005534 hematocrit Methods 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 208000010445 Chilblains Diseases 0.000 description 3
- 241000283977 Oryctolagus Species 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 239000008294 cold cream Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000017423 tissue regeneration Effects 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241001413591 Trifolium arvense Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 210000000544 articulatio talocruralis Anatomy 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229960002275 pentobarbital sodium Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses ointment for treating frostbite and rahagades and a preparation method of the ointment. The ointment is prepared by adding a certain oil phase and aqueous phase into glossy ganoderma and cowherb seed which serve as main medicines, is applied to wounds directly to fulfill the aim of treating the frostbite, and has the characteristics of convenience of use, definite curative effect, no toxic or side effect, safe administration and the like. Simultaneously, results of initial pharmacological and toxicologic experiments indicate that: a medicinal effect of the ointment is obvious, and the total effective rate is estimated to reach more than 90 percent. In addition, in order to store and use the frostbite ointment under the cold condition, sodium chloride is also used in a formula, and antifreezing tests and the investigation of stability of the ointment are performed to achieve the optimum effect.
Description
Invention field
The present invention relates to a kind of ointment, particularly a kind of ointment machin its preparation method of treating frostbite rhagadia.
Background technology
Cold injury is under certain condition because cold acts on human body, the part that causes and even the damage of whole body.The people is in cold district work, life, and human body is in hungry, tired, field work, or the persistent period is more of a specified duration, all is prone to take place cold injury under the conditions such as resisting cold equipment deficiency or footgear discomfort, and is very big to life, quality of life influence.Occur in large tracts of land sleet, the freezing weather of China's southern area beginning of the year in the end of the year to 2008 in 2007, frosted large tracts of land produces for the vast disaster area people and numerous people PLA and officers and men People's Armed Police etc. that participate in the freeze proof disaster relief and has all caused huge threat.
Our reference for modern traditional Chinese medical science is to the theoretical point view of pernosis because of, pathological study; Selecting Ganoderma and Semen Vaccariae is principal agent, and the prescriptions of Chinese medicine of research control frostbite rhagadia is theoretical according to Chinese medical discrimination: Semen Vaccariae; The property of medicine is bitter, flat, ability promoting blood circulation to restore menstrual flow, promoting tissue regeneration and ulcer healing; Ganoderma property is sweet, flat, and beneficial void is held back skin ulcer.Both mutually 5, become altogether that beneficial void is stimulated the menstrual flow, the merit of promoting tissue regeneration and ulcer healing.This prescriptions of Chinese medicine preparation reaches promoting tissue regeneration and ulcer healing, prevention and treats frosted purpose through directly spreading upon the affected part.
Summary of the invention
The object of the present invention is to provide a kind of ointment of treating frostbite rhagadia, another purpose is open its preparation method.
The present invention seeks to realize through following technical scheme:
The raw material of ointment of the present invention consists of:
Oil phase:
Glyceryl monostearate 3-10 weight portion
Stearic acid 6-15 weight portion
Vaseline 1-7 weight portion
Liquid paraffin 3-10 weight portion
Essence is an amount of
Lanoline 3-12 weight portion
Water:
Triethanolamine 1-8 weight portion
Sodium chloride 0.4-3 weight portion
Ethyl hydroxybenzoate 0.1-0.8 weight portion
Principal agent:
Ganoderma 2-15 weight portion
Semen Vaccariae 4-20 weight portion
The raw material composition of ointment of the present invention is preferably:
Oil phase:
Glyceryl monostearate 6 weight portions
Stearic acid 12 weight portions
Vaseline 2 weight portions
Liquid paraffin 6 weight portions
Essence is an amount of
Lanoline 6 weight portions
Water:
Triethanolamine 4 weight portions
Sodium chloride 0.9 weight portion
Ethyl hydroxybenzoate 0.2 weight portion
Principal agent:
Ganoderma 10 weight portions
Semen Vaccariae 5 weight portions
The raw material composition of ointment of the present invention is preferably:
Oil phase:
Glyceryl monostearate 5 weight portions
Stearic acid 9 weight portions
Vaseline 3 weight portions
Liquid paraffin 8 weight portions
Essence is an amount of
Lanoline 10 weight portions
Water:
Triethanolamine 3 weight portions
Sodium chloride 2.0 weight portions
Ethyl hydroxybenzoate 0.5 weight portion
Principal agent:
Ganoderma 10 weight portions
Semen Vaccariae 10 weight portions
The raw material composition of ointment of the present invention is preferably:
Oil phase:
Glyceryl monostearate 8 weight portions
Stearic acid 10 weight portions
Vaseline 5 weight portions
Liquid paraffin 8 weight portions
Essence is an amount of
Lanoline 6 weight portions
Water:
Triethanolamine 5 weight portions
Sodium chloride 0.6 weight portion
Ethyl hydroxybenzoate 0.3 weight portion
Principal agent:
Ganoderma 13.5 weight portions
Semen Vaccariae 6.5 weight portions
The raw material composition of ointment of the present invention is preferably:
Oil phase:
Glyceryl monostearate 10 weight portions
Stearic acid 8 weight portions
Vaseline 4 weight portions
Liquid paraffin 9 weight portions
Essence is an amount of
Lanoline 12 weight portions
Water:
Triethanolamine 2 weight portions
Sodium chloride 1.5 weight portions
Ethyl hydroxybenzoate 0.7 weight portion
Principal agent:
Ganoderma 8 weight portions
Semen Vaccariae 5 weight portions
Get above-mentioned raw materials,, add conventional adjuvant, process ointment according to common process.
The method for preparing of ointment of the present invention is:
It is broken to measure Ganoderma powder by prescription, adds the soak with ethanol 0.5～24 hour of 3～8 times of weight 70-95%, and the alcohol heating reflux that adds 2～12 times of weight 70-95% extracts 2～8 times; The each extraction 1～5 hour; The alcohol heating reflux that adds 2～12 times of weight 30-70% again extracts 2～8 times, extracts 1～5 hour at every turn, merges ethanol extract; Decompression recycling ethanol is concentrated into that relative density is 0.90-1.30 under the room temperature, makes Ganoderma extractum; Get Semen Vaccariae and pulverize, add the ethanol extraction 2～5 times of 2～10 times of weight 50-70%, extracted 1～5 hour at every turn, merge extractive liquid,, decompression recycling ethanol is concentrated into that relative density is 0.90-1.30 under the room temperature, makes Semen Vaccariae extractum; Take by weighing the raw material of oil phase and aqueous portion by formula ratio,, stir respectively at 80 ℃ of heating for dissolving of temperature; With Semen Vaccariae and Ganoderma extractum heating for dissolving, add aqueous phase after crossing 100 mesh sieves, mix homogeneously is poured aqueous portion in the oil phase into and at the uniform velocity to be stirred, and makes it that fully emulsified evenly it is an amount of to add essence when laying temperature is 60 ℃, continues to stir, and cooling promptly gets.
The method for preparing of ointment of the present invention is preferably:
It is broken to measure Ganoderma powder by prescription, adds the soak with ethanol 8 hours of 8 times of weight 95%, and the alcohol heating reflux that adds 8 times of weight 95% extracts 3 times; The each extraction 2 hours; The alcohol heating reflux that adds 8 times of weight 60% again extracts 3 times, extracts 2 hours at every turn, merges ethanol extract; Decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Ganoderma extractum; Get Semen Vaccariae and pulverize, add the ethanol extraction 3 times of 8 times of weight 60%, extracted 2 hours at every turn, merge extractive liquid,, decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Semen Vaccariae extractum; Take by weighing the raw material of oil phase and aqueous portion by formula ratio,, stir respectively at 80 ℃ of heating for dissolving of temperature; With Semen Vaccariae and Ganoderma extractum heating for dissolving, add aqueous phase after crossing 100 mesh sieves, mix homogeneously is poured aqueous portion in the oil phase into and at the uniform velocity to be stirred, and makes it that fully emulsified evenly it is an amount of to add essence when laying temperature is 60 ℃, continues to stir, and cooling promptly gets.
Ointment of the present invention is principal agent according to the Chinese medical discrimination theory with Ganoderma and Semen Vaccariae, reaches the frosted purpose of treatment through directly spreading upon the affected part, its have easy to use, curative effect clear and definite, have no side effect, characteristics such as drug safety.Show that drug action is obvious, estimate that total effective rate will reach more than 90% through preliminary pharmacology, toxicological experiment result simultaneously; In addition; For ease of storage and the use of cold injury cream of the present invention under cold conditions; The present invention has also used sodium chloride in prescription, and it has been carried out antifreeze test and study on the stability, to reach optimum efficiency.
Following experimental example and embodiment further prove but are not limited to the present invention.
The influence of 1 pair of part frozen rat of experimental example whole blood viscosity, factor I, hematocrit and blood plasma viscosity
Get 24 of rats, be divided into normal group, model group, compound ganoderma cold injury cream group and Ganoderma cold injury cream group at random, 4 groups each 6.Earlier adapted to for 1 week, be the anesthesia shape with 1% pentobarbital sodium lumbar injection then at laboratory.5min in-25 ℃ of ethanol is immersed at the following position of the two metapedes ankle joint of rat except that normal group, cause The cold-injury models.6h begins the administration of dividing into groups after the moulding; Model group does not have any other and handles except that changing every day the gauze, and it is the Ganoderma cold injury cream of principal agent by the preparation of embodiment 1 method that compound ganoderma cold injury cream group uses the compound ganoderma cold injury cream, the Ganoderma cold injury cream group that prepare by embodiment 1 method to use with Ganoderma; Embrocate cold injury cream in the part; Every day 3 times, successive administration 48h, broken end is got blood examination and is tested behind the 52h: whole blood viscosity (adopting NEX.1 type cone-plate formula blood viscosity meter); Hematocrit and blood plasma viscosity (adopting the blood capillary viscosimeter of 1.5 * 75mm), the result sees table 1.
Table 1. is respectively organized the testing result N=6 of cold injury rat whole blood viscosity, plasma viscosity, hematocrit, x
On average± s
Annotate: compare with normal group,
* 1P＜0.01; Compare with model group,
* 2P＜0.01,
* 3P＜0.05
Experimental result shows that model group whole blood viscosity, hematocrit and 3 levels of blood plasma viscosity all are significantly higher than normal group, and each item index of two administration groups all is starkly lower than model group, and compound ganoderma cold injury cream group result is better than Ganoderma cold injury cream group effect.
2 pairs of frosted therapeutical effect of rabbit moderate of experimental example
Get 40 of regular grade new zealand rabbits; Male and female half and half; Be divided into normal group, model group, compound ganoderma cold injury cream group (by the preparation of embodiment 1 method), chilblain cold cream (producing) group and Ganoderma cold injury cream group (is that principal agent is by the preparation of embodiment 1 method with the Ganoderma) at random, 5 groups each 8 by Kang Ren hall pharmaceutcal corporation, Ltd.With the two metapedes cropping of new zealand rabbit, behind the local ethanol disinfection, its biped is dipped in to be equipped with carries out freezingly in-25 ℃ of alcoholic acid constant temperature cooling baths, freezing ends be nature rewarming under the room temperature afterwards.6h begins the administration of dividing into groups after the moulding, and model group does not have any other processing except that changing every day the gauze.The treatment component is for using chilblain cold cream, compound ganoderma cold injury cream and Ganoderma cold injury cream group, volume (employing drainage) in rabbit foot cold injury was measured in beginning in the 1st day after the cold injury respectively at 2,3,5,7 days after.Calculate each time period change in volume value, change in volume value/freeze preceding value * 100% promptly to get change in volume percentage rate (value is in 100% before freezing), as its swelling rate, the result sees table 2 with the change in volume percentage rate.
Table 2 is respectively organized moderate cold injury rabbit and is frozen district's swelling rate testing result %, x
On average± s, n=10
Annotate: compare with model group,
* 1P＜0.01,
* 2P＜0.05.
It is little that experimental result shows that the swelling degree of model group and three administration group 2d before treatment changes; Since the 3rd day; The swelling rate of three administration groups begins rapid decline; To the 7th day, compound recipe cold injury cream group began to occur portion of tissue and loses (freezing preceding normal value), and effect obviously is superior to chilblain cold cream group, Ganoderma cold injury cream group.
Measure the sufficient work of freezing the district of beginning medication treatment back rabbit with image analyzer and deposit area, and calculate to live and deposit area percentage, the result sees table 3.Freeze the district each group rabbit and live and to deposit in the testing result of area, can find out treatment before the 2d therapeutic effect not obvious, the 3rd, 5,7 day, two administration group rabbits were frozen the district and live and deposit area and the model group comparing difference has significance or utmost point significance.
Table 3 is respectively organized moderate cold injury rabbit and is frozen district area testing result %, the x of depositing alive
On average± s, n=10
Annotate: compare with model group,
* 1P＜0.01,
* 2P＜0.05.
The preliminary skin irritation test of experimental example 3 compound ganoderma cold injury cream (pressing the preparation of embodiment 1 method)
Get 10 of new zealand rabbits, about body weight 2.5kg, male and female half and half; Hair outside the buttocks left and right sides is sloughed with depilatory, do not had a mao position in the left side and be coated with substrate (about 3 centimetres of diameters), the right side does not have the hair place and is coated with compound recipe Ganoderma cold injury cream (diameter is identical); Every day twice, continuous 20 days.
Experimental result is found all show IRs such as swell not of coating and substrate position, all grows virgin wool.
Sodium chloride uses in the experimental example 4 cold injury paste formulation prescriptions of the present invention screening and antifreeze test
For ease of storage and the use of cold injury cream of the present invention (by the preparation of embodiment 1 method) under cold conditions, the present invention has used sodium chloride in prescription, and it has been carried out antifreeze test and study on the stability, and to reach optimum efficiency, concrete outcome is following:
Principle: the condensation point of water is 0 ℃, and behind the increase sodium chloride, its condensation point can reduce in the water.
Prescription screening and zest: investigate through prescription, when adding 0.9g sodium chloride in every 100g cold injury cream, cold injury cream can not solidify-20 ℃ of condition held in 1 month, prepared in the process at ointment to add, and it is simple to operate, proportion is less, and preparation is not had influence; And 0.9% sodium chloride solution is a normal saline, when smearing, using cold injury cream to the stingless excitation of skin.
Antifreeze test: be index through the outward appearance of ointment, stretchability and centrifugal test are investigated, in-20 ℃ of condition held 24 hours.The result shows: ointment outward appearance and stretchability all with place before indistinction, and ointment packed in the centrifuge tube, under the 2500r/min condition, centrifugal 30 minutes, observe ointment and do not have the oil-water separation phenomenon.Other gets 10 ointment in-20 ℃ of condition held after 1 month, and it is all up to specification to observe its outward appearance, stretchability, and solidification phenomenon all do not occur.
Study on the stability: pass through prepared ointment according to " accelerated test, influence factor's test have been carried out in Chinese pharmacopoeia version requirement in 2010, are index with inspections such as outward appearance, stretchability, index content item.Investigation is the result show, this reasonable recipe of writing out a prescription, and the result is all up to specification, and does not place product index of correlation contrast, there was no significant difference.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1: the preparation of ointment
Oil phase:
Glyceryl monostearate 10g
Stearic acid 8g
Vaseline 4g
Liquid paraffin 9g
Essence is an amount of
Lanoline 12g
Water:
Triethanolamine 2g
Sodium chloride 1.5g
Ethyl hydroxybenzoate 0.7g
Principal agent:
Ganoderma 8g
Semen Vaccariae 5g
It is broken to measure Ganoderma powder by prescription, adds the soak with ethanol 5 hours of 8 times of weight 95%, and the alcohol heating reflux that adds 8 times of weight 95% extracts 3 times; The each extraction 3 hours; The alcohol heating reflux that adds 8 times of weight 60% again extracts 3 times, extracts 3 hours at every turn, merges ethanol extract; Decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Ganoderma extractum; Get Semen Vaccariae and pulverize, add the ethanol extraction 3 times of 8 times of weight 60%, extracted 2 hours at every turn, merge extractive liquid,, decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Semen Vaccariae extractum; Take by weighing the raw material of oil phase and aqueous portion by formula ratio,, stir respectively at 80 ℃ of heating for dissolving of temperature; With Semen Vaccariae and Ganoderma extractum heating for dissolving, add aqueous phase, mix homogeneously behind 100 mesh sieves excessively; Pour aqueous portion in the oil phase at the uniform velocity stirring, make it fully emulsified even, adding essence was an amount of when laying temperature was 60 ℃; Continue to stir, cooling is processed ointment according to common process.
Embodiment 2: the preparation of ointment
Oil phase:
Glyceryl monostearate 6g
Stearic acid 12g
Vaseline 2g
Liquid paraffin 6g
Essence is an amount of
Lanoline 6g
Water:
Triethanolamine 4g
Sodium chloride 0.9g
Ethyl hydroxybenzoate 0.2g
Principal agent:
Ganoderma 4g
Semen Vaccariae 16g
It is broken to measure Ganoderma powder by prescription, adds the soak with ethanol 10 hours of 4 times of weight 90%, and the alcohol heating reflux that adds 6 times of weight 75% extracts 6 times; The each extraction 4 hours; The alcohol heating reflux that adds 5 times of weight 55% again extracts 5 times, extracts 4 hours at every turn, merges ethanol extract; Decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Ganoderma extractum; Get Semen Vaccariae and pulverize, add the ethanol extraction 4 times of 5 times of weight 55%, extracted 3 hours at every turn, merge extractive liquid,, decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Semen Vaccariae extractum; Take by weighing the raw material of oil phase and aqueous portion by formula ratio,, stir respectively at 80 ℃ of heating for dissolving of temperature; With Semen Vaccariae and Ganoderma extractum heating for dissolving, add aqueous phase, mix homogeneously behind 100 mesh sieves excessively; Pour aqueous portion in the oil phase at the uniform velocity stirring, make it fully emulsified even, adding essence was an amount of when laying temperature was 60 ℃; Continue to stir, cooling is processed ointment according to common process.
Embodiment 3: the preparation of ointment
Oil phase:
Glyceryl monostearate 5g
Stearic acid 9g
Vaseline 3g
Liquid paraffin 8g
Essence is an amount of
Lanoline 10g
Water:
Triethanolamine 3g
Sodium chloride 2.0g
Ethyl hydroxybenzoate 0.5g
Principal agent:
Ganoderma 10g
Semen Vaccariae 10g
It is broken to measure Ganoderma powder by prescription, adds the soak with ethanol 6 hours of 6 times of weight 80%, and the alcohol heating reflux that adds 5 times of weight 85% extracts 5 times; The each extraction 4 hours; The alcohol heating reflux that adds 7 times of weight 60% again extracts 5 times, extracts 4 hours at every turn, merges ethanol extract; Decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Ganoderma extractum; Get Semen Vaccariae and pulverize, add the ethanol extraction 4 times of 6 times of weight 60%, extracted 2 hours at every turn, merge extractive liquid,, decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Semen Vaccariae extractum; Take by weighing the raw material of oil phase and aqueous portion by formula ratio,, stir respectively at 80 ℃ of heating for dissolving of temperature; With Semen Vaccariae and Ganoderma extractum heating for dissolving, add aqueous phase, mix homogeneously behind 100 mesh sieves excessively; Pour aqueous portion in the oil phase at the uniform velocity stirring, make it fully emulsified even, adding essence was an amount of when laying temperature was 60 ℃; Continue to stir, cooling is processed ointment according to common process.
Embodiment 4: the preparation of ointment
Oil phase:
Glyceryl monostearate 8g
Stearic acid 10g
Vaseline 5g
Liquid paraffin 8g
Essence is an amount of
Lanoline 6g
Water:
Triethanolamine 5g
Sodium chloride 0.6g
Ethyl hydroxybenzoate 0.3g
Principal agent:
Ganoderma 13.5g
Semen Vaccariae 6.5g
It is broken to measure Ganoderma powder by prescription, adds the soak with ethanol 8 hours of 5 times of weight 90%, and the alcohol heating reflux that adds 4 times of weight 70% extracts 7 times; The each extraction 5 hours; The alcohol heating reflux that adds 5 times of weight 55% again extracts 7 times, extracts 5 hours at every turn, merges ethanol extract; Decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Ganoderma extractum; Get Semen Vaccariae and pulverize, add the ethanol extraction 4 times of 4 times of weight 55%, extracted 3 hours at every turn, merge extractive liquid,, decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Semen Vaccariae extractum; Take by weighing the raw material of oil phase and aqueous portion by formula ratio,, stir respectively at 80 ℃ of heating for dissolving of temperature; With Semen Vaccariae and Ganoderma extractum heating for dissolving, add aqueous phase, mix homogeneously behind 100 mesh sieves excessively; Pour aqueous portion in the oil phase at the uniform velocity stirring, make it fully emulsified even, adding essence was an amount of when laying temperature was 60 ℃; Continue to stir, cooling is processed ointment according to common process.
Claims (7)
1. ointment of treating frostbite rhagadia is characterized in that the raw material of this ointment consists of:
Oil phase:
Glyceryl monostearate 3-10 weight portion
Stearic acid 6-15 weight portion
Vaseline 1-7 weight portion
Liquid paraffin 3-10 weight portion
Essence is an amount of
Lanoline 3-12 weight portion
Water:
Triethanolamine 1-8 weight portion
Sodium chloride 0.4-3 weight portion
Ethyl hydroxybenzoate 0.1-0.8 weight portion
Principal agent:
Ganoderma 2-15 weight portion
Semen Vaccariae 4-20 weight portion.
2. ointment as claimed in claim 1 is characterized in that the raw material of this ointment consists of:
Oil phase:
Glyceryl monostearate 6 weight portions
Stearic acid 12 weight portions
Vaseline 2 weight portions
Liquid paraffin 6 weight portions
Essence is an amount of
Lanoline 6 weight portions
Water:
Triethanolamine 4 weight portions
Sodium chloride 0.9 weight portion
Ethyl hydroxybenzoate 0.2 weight portion
Principal agent:
Ganoderma 10 weight portions
Semen Vaccariae 5 weight portions.
3. ointment as claimed in claim 1 is characterized in that the raw material of this ointment consists of:
Oil phase:
Glyceryl monostearate 5 weight portions
Stearic acid 9 weight portions
Vaseline 3 weight portions
Liquid paraffin 8 weight portions
Essence is an amount of
Lanoline 10 weight portions
Water:
Triethanolamine 3 weight portions
Sodium chloride 2.0 weight portions
Ethyl hydroxybenzoate 0.5 weight portion
Principal agent:
Ganoderma 10 weight portions
Semen Vaccariae 10 weight portions.
4. ointment as claimed in claim 1 is characterized in that the raw material of this ointment consists of:
Oil phase:
Glyceryl monostearate 8 weight portions
Stearic acid 10 weight portions
Vaseline 5 weight portions
Liquid paraffin 8 weight portions
Essence is an amount of
Lanoline 6 weight portions
Water:
Triethanolamine 5 weight portions
Sodium chloride 0.6 weight portion
Ethyl hydroxybenzoate 0.3 weight portion
Principal agent:
Ganoderma 13.5 weight portions
Semen Vaccariae 6.5 weight portions.
5. ointment as claimed in claim 1 is characterized in that the raw material of this ointment consists of:
Oil phase:
Glyceryl monostearate 10 weight portions
Stearic acid 8 weight portions
Vaseline 4 weight portions
Liquid paraffin 9 weight portions
Essence is an amount of
Lanoline 12 weight portions
Water:
Triethanolamine 2 weight portions
Sodium chloride 1.5 weight portions
Ethyl hydroxybenzoate 0.7 weight portion
Principal agent:
Ganoderma 8 weight portions
Semen Vaccariae 5 weight portions.
6. like the method for preparing of the arbitrary described ointment of claim 1-5, it is characterized in that this method comprises the steps:
It is broken to measure Ganoderma powder by prescription, adds the soak with ethanol 0.5～24 hour of 3～8 times of weight 70-95%, and the alcohol heating reflux that adds 2～12 times of weight 70-95% extracts 2～8 times; The each extraction 1～5 hour; The alcohol heating reflux that adds 2～12 times of weight 30-70% again extracts 2～8 times, extracts 1～5 hour at every turn, merges ethanol extract; Decompression recycling ethanol is concentrated into that relative density is 0.90-1.30 under the room temperature, makes Ganoderma extractum; Get Semen Vaccariae and pulverize, add the ethanol extraction 2～5 times of 2～10 times of weight 50-70%, extracted 1～5 hour at every turn, merge extractive liquid,, decompression recycling ethanol is concentrated into that relative density is 0.90-1.30 under the room temperature, makes Semen Vaccariae extractum; Take by weighing the raw material of oil phase and aqueous portion by formula ratio,, stir respectively at 80 ℃ of heating for dissolving of temperature; With Semen Vaccariae and Ganoderma extractum heating for dissolving, add aqueous phase after crossing 100 mesh sieves, mix homogeneously is poured aqueous portion in the oil phase into and at the uniform velocity to be stirred, and makes it that fully emulsified evenly it is an amount of to add essence when laying temperature is 60 ℃, continues to stir, and cooling promptly gets.
7. the method for preparing of ointment as claimed in claim 6 is characterized in that this method comprises the steps:
It is broken to measure Ganoderma powder by prescription, adds the soak with ethanol 8 hours of 8 times of weight 95%, and the alcohol heating reflux that adds 8 times of weight 95% extracts 3 times; The each extraction 2 hours; The alcohol heating reflux that adds 8 times of weight 60% again extracts 3 times, extracts 2 hours at every turn, merges ethanol extract; Decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Ganoderma extractum; Get Semen Vaccariae and pulverize, add the ethanol extraction 3 times of 8 times of weight 60%, extracted 2 hours at every turn, merge extractive liquid,, decompression recycling ethanol is concentrated into that relative density is 0.95-1.20 under the room temperature, makes Semen Vaccariae extractum; Take by weighing the raw material of oil phase and aqueous portion by formula ratio,, stir respectively at 80 ℃ of heating for dissolving of temperature; With Semen Vaccariae and Ganoderma extractum heating for dissolving, add aqueous phase after crossing 100 mesh sieves, mix homogeneously is poured aqueous portion in the oil phase into and at the uniform velocity to be stirred, and makes it that fully emulsified evenly it is an amount of to add essence when laying temperature is 60 ℃, continues to stir, and cooling promptly gets.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104173215A (en) * | 2013-05-21 | 2014-12-03 | 江苏天恒纳米科技有限公司 | Hand cream for preventing chilblains |
| CN104784243A (en) * | 2015-03-23 | 2015-07-22 | 北京协和药厂 | Application of traditional Chinese medicinal composition capable of effectively treating frostbite rhagadia to prevention and treatment of diabetic foot |
| CN105106106A (en) * | 2015-09-06 | 2015-12-02 | 江南大学 | Preparation method of vaccarin ointment |
| CN108653530A (en) * | 2018-08-22 | 2018-10-16 | 韩加会 | It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite |
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| CN101199688A (en) * | 2007-12-13 | 2008-06-18 | 张益军 | Tincture dose medicament for treating part frozen |
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| CN101199688A (en) * | 2007-12-13 | 2008-06-18 | 张益军 | Tincture dose medicament for treating part frozen |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173215A (en) * | 2013-05-21 | 2014-12-03 | 江苏天恒纳米科技有限公司 | Hand cream for preventing chilblains |
| CN104784243A (en) * | 2015-03-23 | 2015-07-22 | 北京协和药厂 | Application of traditional Chinese medicinal composition capable of effectively treating frostbite rhagadia to prevention and treatment of diabetic foot |
| CN104784243B (en) * | 2015-03-23 | 2018-06-26 | 北京协和药厂 | A kind of application of Chinese medicine composition that can effectively treat frostbite rhagadia in prevention, treatment diabetes |
| CN105106106A (en) * | 2015-09-06 | 2015-12-02 | 江南大学 | Preparation method of vaccarin ointment |
| CN105106106B (en) * | 2015-09-06 | 2018-02-06 | 江南大学 | A kind of preparation method of Vaccarin ointment |
| CN108653530A (en) * | 2018-08-22 | 2018-10-16 | 韩加会 | It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite |
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|---|---|
| CN102309536B (en) | 2013-01-23 |
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Address after: 102600 building 7, 37 Yongwang Road, Daxing biomedical industrial base, Zhongguancun Science and Technology Park, Daxing District, Beijing Patentee after: Beijing Xiehe Pharmaceutical Co.,Ltd. Patentee after: The 302 Hospital of the Chinese people's Liberation Army Address before: 100050 Beijing city Xuanwu District xiannongtan No. 1 Patentee before: Beijing Union Pharmaceutical Factory Patentee before: The 302 Hospital of the Chinese people's Liberation Army |
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