CN102308916B - Novel enteric sustained-release pellet for feed and preparation method thereof - Google Patents
Novel enteric sustained-release pellet for feed and preparation method thereof Download PDFInfo
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- CN102308916B CN102308916B CN2011102243381A CN201110224338A CN102308916B CN 102308916 B CN102308916 B CN 102308916B CN 2011102243381 A CN2011102243381 A CN 2011102243381A CN 201110224338 A CN201110224338 A CN 201110224338A CN 102308916 B CN102308916 B CN 102308916B
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Abstract
The invention relates to a novel enteric sustained-release zinc oxide-oligosaccharide composite pellet for feed and a preparation method thereof. The novel enteric sustained-release zinc oxide-oligosaccharide composite pellet for feed comprises: by weight, 38 to 75% of zinc oxide powder, 15 to 35% of oligosaccharide, 2 to 14% of starch, 1.5 to 5.5% of cellulose acetate-phthalate, 0.05 to 0.1% of sodium alginate, 4.5 to 9.5% of talcum powder, and 0.15 to 0.5% of diethyl phthalate. The novel enteric sustained-release zinc oxide-oligosaccharide composite pellet for feed has the advantages of good effects of dissolution in the enteric canal and good treatment effects.
Description
Technical field:
The present invention relates to a kind of novel feed zinc oxide, the compound enteric sustained-release pellet of oligosaccharides and preparation method thereof, in feed, add bioavailability in the animal body that this kind sustained release pellet not only can improve zinc oxide, simultaneously, oligosaccharides in the micropill can improve the daily gain of animal, reduce material anharmonic ratio and diarrhea rate, have good economic use value.
Background technology:
Zinc is the constituent of 40 plurality of enzymes in the human body, processes such as it has participated in nucleic acid and protein is synthetic, energetic supersession, redox.Studies show that, an amount of zinc can effectively promote the organism metabolism of animal, the zinc that adds doses in feed can promote intestinal villus and the enterocyte hyperplasia of piglet, accelerate to repair the intestinal mucosa and the fine hair damage that cause because of ablactation stress, significantly alleviated the generation of post-weaning diarrhea in piglet, stimulate piglet growth, improve daily gain, and have good antibacterial action, thus reduced feedstuff-meat ratio, reduce production cost.
Because the zinc oxide bioavailability is lower, present feed producer adds the zinc oxide of high dose and suffers from diarrhoea to prevent piglet white scour in the weanling pig daily ration, thereby causes the abuse of zinc.The zinc that adds high dose in the feed can cause element metabolism disorders such as iron, copper in the piglet body, high zinc has the effect of antagonism calcium ion simultaneously, have a strong impact on growth in piglets and grow, the zinc of high dose is difficult for absorbing in animal alimentary canal simultaneously, thereby causes environmental pollution with the ight soil discharge.Yu Yanhu (2003) studies show that the zinc that adds in the wean piglet diet in the production practices is up to 2500～3000mg/kg, and wherein about 90～95% zinc is discharged from ight soil.Though this high zinc daily ration is only fed several weeks; but the total amount of discharging zinc is quite high; can cause the bad reaction of environmental pollution and animal; therefore; from safeguarding food security and protection environmental, designing the high enteric zinc oxide sustained release pellet of a kind of bioavilability can address the above problem.
For a long time, grice diarrhoea is usually prevented and controlled to people's custom by add antibiosis in feed, promotes piglet growth.Yet, this traditional technological means has caused pig body intestinal mucosa epithelial cell damage, livestock products descend safely and problem such as environmental pollution, and wood oligose, galactomannan-oligosaccharide, manna oligosacchride, FOS are as the feed addictive kind of national regulation, not only have the function of improving the livestock and poultry alimentary tract flora and promoting beneficial bacterium propagation, but also be good immunomodulator.
Wood oligose is a kind of novel feed addictive, be difficult for being decomposed, have characteristics acidproof, heat-resisting, good stability, Zhang Xiujiang etc. studies show that, the feeding xylo-oligosaccharide can improve the intestine of young pigs environment, reduce wean back feed to piglet stress, promote the health of piglet, improve its disease-resistant performance, reduce the grice diarrhoea rate.
Galactomannan-oligosaccharide claims the galactomannan compound sugar again, is the oligosaccharides that is connected and composed by glycosidic bond by galactomannan sugar and glucose.Hou Zhen equality is investigated the diversity of weanling pig enteric microorganism by the feeding galactomannan-oligosaccharide, the result shows, galactomannan-oligosaccharide promotes enteron aisle to educate the propagation of beneficial bacterium in animal body, reduce enteric pathogenic bacteria, improve the integrality of intestinal mucosa, improve the production performance of animal thereby regulate the animal immune reaction.
Manna oligosacchride claims mannan-oligosaccharides or grape manna oligosaccharide sugar again, extensively is present in konjaku flour, melon bean gum, sesbania gum and the multiple microorganism wall.You Jinming etc. discover, add sodium butyrate and manna oligosacchride in feed, can strengthen weanling pig to the specific immune response of OVA.Manna oligosacchride optionally promotes the propagation of beneficial bacterium, suppresses or the elimination pathogen.
FOS claims fructooligosaccharide or FOS again, is a class Bifidobacterium MF, characteristic such as have low heat value, stable, noresidue, have no drug resistance.Tan Congling etc. add the FOS of doses in feed, study it to the influence of growth pig production performance and immunity function, result of study shows, compare with control group, add 0.3% in the growth pig diet, FOS can significantly improve serum IgA concentration, and the apparent digestibility of the growth performance of raising growth pig and diet thick protein, crude fat can strengthen immunity function of animal.
Therefore, the novel zinc oxide one oligosaccharides composite slow release micropill of the present invention's development, namely in the zinc oxide sustained release pellet, add the oligosaccharides of doses, can improve the interior bioavailability of animal body of zinc oxide, can improve the livestock and poultry alimentary tract flora again and promote beneficial bacterium propagation, improve the daily gain of animal, reduce material anharmonic ratio and diarrhea rate, have good economic use value.
Summary of the invention:
The present invention relates to a kind of novel feed zinc oxide, the compound enteric sustained-release pellet of oligosaccharides and preparation method thereof, the weight proportion of concrete raw material is as follows:
Preparing medicine material preferred weight percent of the present invention is:
Oxide powder and zinc 40%-70%
Oligosaccharides 15%-30%
Starch 5%-12%
Zinc oxide, oligosaccharides, starch are prepared the slowly-releasing ball heart according to the above ratio, and sustained-release coating layer is made of slow-release material, lubricant, antiplastering aid and plasticizer, and wherein the filmogen of the enteric layer of sustained-release coating layer is cellulose acetate-phthalate; Lubricant and antiplastering aid are talcum powder; Plasticizer is preferred sodium alginate and diethyl phthalate then.
The zinc oxide that the present invention relates to-oligosaccharides composite slow release micropill by containing pill core and sustained-release coating layer constitutes, is characterized in that described ball core is made of zinc oxide, oligosaccharides and starch, and wherein, the percentage that zinc oxide content accounts for ball heart gross weight is 38%-75%; The percentage that oligosaccharide content accounts for ball heart gross weight is 15%-35%.
The present invention relates to a kind of preparation method of zinc oxide sustained release pellet, may further comprise the steps:
1, mixes
Press recipe quantity, zinc oxide, oligosaccharides and starch are joined in the mixer, mixed 10 minutes, stand-by.
2, preparation softwood
Mixed zinc oxide is placed in the granulator, add hot water and make softwood.
3, extruding is round as a ball
With softwood based in the extruder, be extruded into granular or strip after, place spheronizator round as a ball.
4, drying
With the micropill after round as a ball drying machine inner drying 30 minutes.
5, sieve
Micropill is crossed 30 orders and 80 mesh sieves, place in the clean polybag, and weighing.
6, the preparation of coating solution
(1) solvent is placed rustless steel container.
(2) stir with agitator, slowly coating material is added in the solvent, notice in the interpolation process that agglomerate produces, continuous stirring is up to dissolving fully, and is labelled standby.
7, dressing
The zinc oxide micropill is placed in the coating pan, start coating pan, preheating.
Use the coating solution of step 6 preparation to carry out dressing, wherein the peristaltic pump rotating speed of coating pan is 20rpm, and compressed air pressure is 40psi, and the material bed tempertaure is 30-35 ℃, and the spray gun model is: W-71
8, drying
After coating solution has sprayed, coating pan inner drying 10 minutes, then micropill is placed on the basin, in 40 ℃ of dried overnight earlier.
9, sieve
Micropill is crossed 30 orders and 80 mesh sieves, place in the clean polybag, and weighing.
10, packing: woven bag packing, every bag of 20kg.
The specific embodiment:
1, zinc oxide one FOS composite slow release micropill
The preparation method: with the described oxide powder and zinc of above-described embodiment, FOS and starch in accordance with regulations dosage mix, and place mixer-granulator; Add hot water and make softwood, through the extruding, round as a ball, dry, sieve and make the zinc oxide micropill of diameter between 0.3-0.9mm, coating material is made into the aqueous suspension of 10% concentration, stirs and add talcum powder, sodium alginate and diethyl phthalate down, keep stirring; The zinc oxide micropill is placed the dressing machine, start the dressing machine, carry out the hydrojet dressing, make enteric-coated micro-pill, the micropill diameter control of making is between 0.3-0.9mm.
The result: in simulated gastric fluid and simulated intestinal fluid, measure, specific as follows:
2, zinc oxide, galactomannan-oligosaccharide composite slow release micropill
The preparation method: with the described oxide powder and zinc of above-described embodiment, galactomannan-oligosaccharide and starch in accordance with regulations dosage mix, and place mixer-granulator; Add hot water and make softwood, through the extruding, round as a ball, dry, sieve and make the zinc oxide micropill of diameter between 0.3-0.9mm, coating material is made into the aqueous suspension of 10% concentration, stirs and add talcum powder, sodium alginate and diethyl phthalate down, keep stirring; The zinc oxide micropill is placed the dressing machine, start the dressing machine, carry out the hydrojet dressing, make enteric-coated micro-pill, the micropill diameter control of making is between 0.3-0.9mm.
The result: in simulated gastric fluid and simulated intestinal fluid, measure, specific as follows:
3, zinc oxide one wood oligose composite slow release micropill
The preparation method: with the described oxide powder and zinc of above-described embodiment, wood oligose and starch in accordance with regulations dosage mix, and place mixer-granulator; Add hot water and make softwood, through the extruding, round as a ball, dry, sieve and make the zinc oxide micropill of diameter between 0.3-0.9mm, coating material is made into the aqueous suspension of 10% concentration, stirs and add talcum powder, sodium alginate and diethyl phthalate down, keep stirring; The zinc oxide micropill is placed the dressing machine, start the dressing machine, carry out the hydrojet dressing, make enteric-coated micro-pill, the micropill diameter control of making is between 0.3-0.9mm.
The result: in simulated gastric fluid and simulated intestinal fluid, measure, specific as follows:
4, zinc oxide-manna oligosacchride composite slow release micropill
The preparation method: with the described oxide powder and zinc of above-described embodiment, manna oligosacchride and starch in accordance with regulations the agent star mix, and place mixer-granulator; Add hot water and make softwood, through the extruding, round as a ball, dry, sieve and make the zinc oxide micropill of diameter between 0.3-0.9mm, coating material is made into the aqueous suspension of 10% concentration, stirs and add talcum powder, sodium alginate and diethyl phthalate down, keep stirring; The zinc oxide micropill is placed the dressing machine, start the dressing machine, carry out the hydrojet dressing, make enteric-coated micro-pill, the micropill diameter control of making is between 0.3-0.9mm.
The result: in simulated gastric fluid and simulated intestinal fluid, measure, specific as follows:
Claims (5)
1. a zinc oxide, oligosaccharides compound sustained release pellet comprise the ball heart and sustained-release coating layer two parts, it is characterized in that it is by the preparation of following weight proportion raw material, and be specific as follows:
1) the ball heart: oxide powder and zinc 25%-75% oligosaccharides 10%-35% starch 2%-20%
2) sustained-release coating layer: cellulose acetate-phthalate 1.5%-5.5% sodium alginate 0.05%-0.2% talcum powder 1%-10% diethyl phthalate 0.15%-0.25%
Wherein, oligosaccharides comprises a kind of in wood oligose, galactomannan-oligosaccharide, manna oligosacchride and the FOS.
2. according to the described zinc oxide of claim 1, oligosaccharides compound sustained release pellet, it is characterized in that wherein the weight proportion of each raw material is:
1) the ball heart: oxide powder and zinc 30%-70% oligosaccharides 15%-30% starch 5%-15%
2) the enteric solubility material contains thing admittedly: cellulose acetate-phthalate 2%-5% sodium alginate 0.05%-0.2% talcum powder 1%-9% diethyl phthalate 0.15%-0.25%
Wherein, oligosaccharides comprises a kind of in art oligosaccharides, galactomannan-oligosaccharide, manna oligosacchride and the FOS.
3. according to the described zinc oxide of claim 1, oligosaccharides compound sustained release pellet, the percentage that zinc oxide content accounts for ball heart gross weight is 38%-75%; The percentage that oligosaccharide content accounts for ball heart gross weight is 15%-35%.
4. zinc oxide according to claim 1, oligosaccharides compound sustained release pellet, the weight ratio of the described ball heart and sustained-release coating layer is: 1: 0.03～0.08.
5. the preparation method of a zinc oxide, oligosaccharides compound sustained release pellet may further comprise the steps:
1) the preparation ball heart:
25%-75% zinc oxide, 10%-35% oligosaccharides were mixed 10 minutes with 2%-20% starch, be placed in the granulator again, add hot water and make softwood, adopt the squeezing roll circule method to prepare the zinc oxide micropill, drying is sieved, and is stand-by;
2) preparation of coating solution:
Select the described sustained-release coating layer of claim 1 in accordance with regulations dosage be made into the aqueous solution of 10% concentration, stir the talcum powder that adds prescribed dose down, stir, stand-by;
3) micropill dressing:
The ball heart that step 1 is made places the dressing machine, starts the dressing machine, and dressing program dressing is made enteric-coated micro-pill routinely, and the micropill diameter control of making is between 0.3～0.9mm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102243381A CN102308916B (en) | 2011-08-04 | 2011-08-04 | Novel enteric sustained-release pellet for feed and preparation method thereof |
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| CN2011102243381A CN102308916B (en) | 2011-08-04 | 2011-08-04 | Novel enteric sustained-release pellet for feed and preparation method thereof |
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| CN102308916A CN102308916A (en) | 2012-01-11 |
| CN102308916B true CN102308916B (en) | 2013-08-28 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103549162B (en) * | 2013-11-02 | 2014-10-08 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
| CN103766658B (en) * | 2014-01-23 | 2015-06-17 | 浙江大学 | Pig feed additive with low emissions of carbon and nitrogen |
| CN103766606A (en) * | 2014-01-23 | 2014-05-07 | 浙江大学 | Feed additive capable for reducing emissions of nitrogen and ammonia in poultry farming |
| CN104922681A (en) * | 2015-05-23 | 2015-09-23 | 江苏南农高科动物药业有限公司 | Animal enteric film coating solution and preparation method as well as application thereof |
| CN108740371B (en) * | 2018-04-04 | 2021-07-30 | 广州智特奇生物科技股份有限公司 | Enteric coating material, zinc oxide coated by coating material and preparation method thereof |
| CN109805187A (en) * | 2019-01-09 | 2019-05-28 | 珠海天凯生物科技有限公司 | A kind of somatotrophic feed addictive of non-antibiotic class antibacterial |
| CN112262926B (en) * | 2020-11-03 | 2023-08-04 | 成都蜀星饲料有限公司 | Zinc oxide enteric sustained-release pellet, preparation method thereof and feed composition containing zinc oxide enteric-release pellet |
| CN114532448A (en) * | 2022-03-11 | 2022-05-27 | 重庆威迪特药业有限责任公司 | Powder-coated zinc oxide preparation with high gastric hyperacidity rate as well as preparation method and application thereof |
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